2026/04/17 更新

写真a

オバタ　ヒロアキ
小幡　裕明
OBATA Hiroaki
所属
医歯学総合研究科 特任准教授
職名
特任准教授
外部リンク

学位

  • 博士（医学） （ 2008年3月 ）

経歴

  • 新潟大学   医歯学総合研究科   特任准教授

    2024年4月 - 現在

  • 新潟大学   医歯学総合病院　循環器内科   特任助教

    2013年4月 - 2024年3月

 

論文

  • Impact and management of integrated dysphagia rehabilitation within cardiac care programs for older patients with cardiovascular disease 査読

    Hiroaki Obata, Tohru Izumi, Mitsuo Ishizuka, Kenji Yamaguchi, Naohito Hao, Nobue Yagihara, Satoru Abe, Hiroshi Watanabe, Takayuki Inomata, Shigeru Makita, Shigeru Fujimoto

    European Geriatric Medicine   2024年8月

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    担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

    Abstract

    Purpose

    This study assessed the characteristics, management, and outcomes of dysphagia rehabilitation in older patients with CVD in a super-aged society, highlighting the need for comprehensive management strategies in community hospital settings. It aimed to uncover valuable insights into the benefits of integrating dysphagia rehabilitation with cardiac care in patient management.

    Methods

    We conducted a retrospective review of patients with CVD aged ≥ 65 years who were admitted to Niigata Minami Hospital between January 2019 and December 2021. We focused on patients requiring dysphagia rehabilitation and assessing the effects of these interventions on recovery.

    Results

    The study included 732 participants with an average age of 86.0 ± 7.8 years, of whom 41.9% were male. Approximately 55.1% required dysphagia rehabilitation. Dysphagia rehabilitation significantly improved oral caloric intake and BMI in patients who underwent rehabilitation, and these improvements were comparable to those in patients who did not require dysphagia rehabilitation. Significant enhancement in the ADL of patients was observed at discharge. Patients who required dysphagia rehabilitation also had longer hospital stays and were more likely to be discharged to nursing facilities.

    Conclusion

    Dysphagia is common in older patients with CVD, and dysphagia rehabilitation positively affects the maintenance of nutritional status and helps patients achieve ADL independence at discharge. This study highlights the importance of integrating dysphagia rehabilitation into ordinary cardiac rehabilitation programs for older patients with CVD to improve their QOL.

    DOI： 10.1007/s41999-024-01031-9

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    その他リンク： https://link.springer.com/article/10.1007/s41999-024-01031-9/fulltext.html

  • Overlapping states of AWGS muscle dysfunction and inverse feasibility of ADL recovery by rehabilitation in older inpatients 査読

    Masashi Yamashita, Hiroaki Obata, Kentaro Kamiya, Atsuhiko Matsunaga, Kazuki Hotta, Tohru Izumi

    Scientific Reports   12 ( 1 )   2022年12月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

    Abstract

    Rehabilitation based on guided walking is effective to recover activity of daily living (ADL) in frail older adults, even octogenarians. However, muscle dysfunction obviously reflects disability, and few studies have focused on ADL recovery by rehabilitation. We employed the state of muscle dysfunctions proposed by the Asian Working Group for Sarcopenia (AWGS) in 2019 and attempted to clarify the relation between the overlapping dysfunctions and the feasibility of ADL recovery after rehabilitation. In total, 297 frail older patients (the mean age: 82.8 years, 46.1% of patients were male) participated in a walking-guided rehabilitation program to achieve the goal of ambulatory discharge. Muscle dysfunction was categorized by four standardized methods at the start of rehabilitation (grip strength, gait speed, time of five sit-to-stand, and short physical performance battery: SPPB), according to the AWGS proposal. ADLs were monitored by Barthel index before admission, at the start of rehabilitation, and at discharge. At least one dysfunction was present in 95.3% of patients. If a single patient had three or more muscle dysfunction, the ADLs recovery was significantly limited (interaction: p < 0.05). The overlapped counts of AWGS muscle dysfunction helps to predict inverse feasibility of ADL recovery in frail older patients through rehabilitation.

    DOI： 10.1038/s41598-022-26622-z

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    その他リンク： https://www.nature.com/articles/s41598-022-26622-z

  • JCS/JACR 2021 Guideline on Rehabilitation in Patients With Cardiovascular Disease

    Shigeru Makita, Takanori Yasu, Yoshihiro J Akashi, Hitoshi Adachi, Hideo Izawa, Shunichi Ishihara, Yoshitaka Iso, Hideo Ohuchi, Kazuto Omiya, Yusuke Ohya, Koichi Okita, Yutaka Kimura, Akira Koike, Masahiro Kohzuki, Shinji Koba, Masataka Sata, Kazunori Shimada, Tomoki Shimokawa, Hirokazu Shiraishi, Naokata Sumitomo, Tetsuya Takahashi, Tomoyuki Takura, Hiroyuki Tsutsui, Masatoshi Nagayama, Emiko Hasegawa, Yoshihiro Fukumoto, Yutaka Furukawa, Shin-ichiro Miura, Satoshi Yasuda, Sumio Yamada, Yuichiro Yamada, Dai Yumino, Toshiko Yoshida, Takuji Adachi, Toshimi Ikegame, Kazuhiro P Izawa, Takeshi Ishida, Neiko Ozasa, Naohiko Osada, Hiroaki Obata, Naoya Kakutani, Yusuke Kasahara, Masaaki Kato, Kentaro Kamiya, Shintaro Kinugawa, Yuji Kono, Yasuyuki Kobayashi, Teruyuki Koyama, Kazuhiro Sase, Shinji Sato, Tatsuhiro Shibata, Norio Suzuki, Daisuke Tamaki, Minako Yamaoka-Tojo, Michio Nakanishi, Eisaku Nakane, Mari Nishizaki, Taiki Higo, Kanta Fujimi, Tasuku Honda, Yasuharu Matsumoto, Noriko Matsumoto, Ikuko Miyawaki, Makoto Murata, Shusuke Yagi, Masanobu Yanase, Midori Yamada, Miho Yokoyama, Noboru Watanabe, Haruki Ito, Takeshi Kimura, Syunei Kyo, Yoichi Goto, Ryuji Nohara, Ken-Ichi Hirata

    Circulation Journal   87 ( 1 )   155 - 235   2022年12月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Circulation Society  

    DOI： 10.1253/circj.cj-22-0234

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  • Characteristics of Elderly Patients with Heart Failure and Impact on Activities of Daily Living: A Registry Report from Super-Aged Society 査読

    Hiroaki Obata, Tohru Izumi, Masashi Yamashita, Wataru Mitsuma, Keisuke Suzuki, Shinichi Noto, Takeshi Morimoto, Mitsuaki Isobe

    Journal of Cardiac Failure   27 ( 11 )   1203 - 1213   2021年11月

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    担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    DOI： 10.1016/j.cardfail.2021.05.008

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  • The baseline speed of 10-m gait predicts ambulatory discharge for hospitalized frail elderly after DOPPO rehabilitation 査読

    Akifumi Uehara, Hiroaki Obata, Hiroshi Watanabe, Yuki Izumi, Yorio Suzuki, Tohru Izumi

    International Journal of Rehabilitation Research   41 ( 4 )   331 - 336   2018年12月

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    担当区分：責任著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：Ovid Technologies (Wolters Kluwer Health)  

    The discharge of elderly patients from hospital on the basis of their independent gait program (DOPPO) is a new rehabilitation strategy for physically frail hospitalized elderly that aims to recover independent gait and to achieve ambulatory discharge. We retrospectively investigated baseline determinants of physical measures associated closely with the 6-min walking distance (6MWD) after DOPPO. Participants were 137 consecutive elderly inpatients, irrespective of the causative disease (mean age: 82±7 years; 76 women), who had a Short Physical Performance Battery (SPPB) score of less than 12 and low independent walking capacity. The rehabilitation comprised muscle stretching, muscle strengthening, balance training, and endurance exercise, including walking. The exercises were gradually increased until the goal of ambulatory discharge was attained. The SPPB, isometric knee-extension muscle strength (IKEMS), functional reach test (FRT), one-leg stance time (OLST), and the 10-m gait speed (TMGS) were measured, before and after the DOPPO intervention, and their association with the 6MWD was evaluated. All participants achieved ambulatory discharge, requiring on average 35±19 hospital days and 32±18 h of rehabilitation. The SPPB, IKEMS, FRT, OLST, and TMGS improved. The SPPB scores increased from 7.1 at baseline to 9.2 at discharge. Eighty-eight patients completed the 6MWD. The SPPB, IKEMS, FRT, OLST, and TMGS were strongly associated with the 6MWD. Only the baseline TMGS and SPPB predicted the 6MWD, with a cut-off TMGS value of 0.84 m/s providing the best prediction of achieving a distance of more than 300 m on the 6MWD. Thus, the baseline TMGS is the best prediction of the ambulatory outcome after the present DOPPO rehabilitation.

    DOI： 10.1097/mrr.0000000000000308

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  • Single Injection of a Sustained-release Prostacyclin Analog Improves Pulmonary Hypertension in Rats 査読

    Hiroaki Obata, Yoshiki Sakai, Shunsuke Ohnishi, Satoshi Takeshita, Hidezo Mori, Makoto Kodama, Kenji Kangawa, Yoshifusa Aizawa, Noritoshi Nagaya

    American Journal of Respiratory and Critical Care Medicine   177 ( 2 )   195 - 201   2008年1月

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    担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：American Thoracic Society  

    DOI： 10.1164/rccm.200703-349oc

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  • 介護者の少ない高齢心不全患者の臨床的特徴(Clinical Characteristics of Elderly Heart Failure Patients with Few Caregivers)

    酒井 亮平, 小幡 裕明, 阿部 暁, 藤木 伸也, 高山 亜美, 石原 嗣郎, 柏村 健, 三間 渉, 鈴木 啓介, 猪又 孝元, 和泉 徹

    日本循環器学会学術集会抄録集   87回   PJ080 - 6   2023年3月

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    記述言語：英語   出版者・発行元：(一社)日本循環器学会  

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  • 介護者の少ない高齢心不全患者の臨床的特徴(Clinical Characteristics of Elderly Heart Failure Patients with Few Caregivers)

    酒井 亮平, 小幡 裕明, 阿部 暁, 藤木 伸也, 高山 亜美, 石原 嗣郎, 柏村 健, 三間 渉, 鈴木 啓介, 猪又 孝元, 和泉 徹

    日本循環器学会学術集会抄録集   87回   PJ080 - 6   2023年3月

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    記述言語：英語   出版者・発行元：(一社)日本循環器学会  

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  • Adipokines in patients with heart failure under rehabilitation 査読

    Shinya Fujiki, Hiroshi Watanabe, Hiroaki Obata, Masayoshi Suda, Wataru Mitsuma, Asako Tomii, Katsuyuki Sakai, Akifumi Uehara, Ippei Shimizu, Takeshi Kashimura, Kazuyuki Ozaki, Tohru Minamino

    Acta Biomedica   92 ( 3 )   2021年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Mattioli 1885  

    DOI： 10.23750/abm.v92i3.9228

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  • Diastolic Wall Strain Predicts Clinical Worsening of Fulminant Myocarditis: Exploratory Findings from Four Case Reports 査読

    Shinya Fujiki, Hiroaki Obata, Takeshi Kashimura, Komei Tanaka, Haruo Hanawa, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   21 ( 10 )   S164 - S165   2015年10月

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  • Characteristics of Sarcopenia in Patients with Heart Failure 査読

    Hiroaki Obata, Toru Izumi, Wataru Mitsuma, Asako Tomii, Katsuyuki Sakai, Akifumi Uehara, Tohru Watanabe, Takeshi Kashimura, Haruo Hanawa, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S160 - S160   2014年10月

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  • 1．薬物治療up to date

    103 ( 2 )   378 - 386   2014年

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    担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

    DOI： 10.2169/naika.103.378

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  • A Case of Pulmonary Tumor Thrombotic Microangiopathy Caused by Adenocarcinoma of Unknown Primary Site 査読

    Hiroaki Obata, Makoto Tomita, Hajime Umezu, Takeshi Kashimura, Haruo Hanawa, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   19 ( 10 )   S173 - S173   2013年10月

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  • A Case of Chronic Lupus Myocarditis 査読

    Takayuki Wakasugi, Hiroaki Obata, Go Hasegawa, Takeshi Kashimura, Haruo Hanawa, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   19 ( 10 )   S159 - S159   2013年10月

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  • Oral Administration of a Novel Long-Acting Prostacyclin Agonist With Thromboxane Synthase Inhibitory Activity for Pulmonary Arterial Hypertension 査読

    Atsuhiro Nakamura, Noritoshi Nagaya, Hiroaki Obata, Katsuya Sakai, Yoshiki Sakai, Masanori Yoshikawa, Kaoru Hamada, Kunio Matsumoto, Hiroshi Kimura

    Circulation Journal   77 ( 8 )   2127 - 2133   2013年

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Circulation Society  

    DOI： 10.1253/circj.cj-13-0107

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  • Improvement of anemia with decreasing hepcidin levels following valve replacement for severe tricuspid regurgitation 査読

    Tomoyasu Suzuki, Haruo Hanawa, Limin Ding, Masahiro Ito, Takeshi Kashimura, Hiroaki Obata, Ying Hua Hu, Shuang Jiao, Osamu Namura, Makoto Kodama

    EUROPEAN JOURNAL OF HAEMATOLOGY   88 ( 6 )   551 - 552   2012年6月

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  • Effects of Combination Therapy With Warfarin and Bucolome for Anticoagulation in Patients With Atrial Fibrillation 査読

    Hiroaki Obata, Hiroshi Watanabe, Masahiro Ito, Satoru Hirono, Haruo Hanawa, Makoto Kodama, Yoshifusa Aizawa

    Circulation Journal   75 ( 1 )   201 - 203   2011年

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    担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Circulation Society  

    DOI： 10.1253/circj.cj-10-0842

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  • Sudden Cardiac Arrest after Subarachnoid Hemorrhage 査読

    Wataru Mitsuma, Masahiro Ito, Hiroaki Obata, Makoto Kodama

    INTERNAL MEDICINE   50 ( 17 )   1859 - 1859   2011年

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  • Selective Delivery of siRNA Nanoparticles Targeting MEK Attenuates Experimental Pulmonary Hypertension 査読

    Hiroaki Obata, Nobuhiro Yagi, Shunsuke Ohnishi, Kenichi Yamahara, Toshihito Hosokawa, Ichiro Manabe, Makoto Kodama, Yoshifusa Aizawa, Ryozo Nagai, Noritoshi Nagaya

    CIRCULATION   120 ( 18 )   S841 - S841   2009年11月

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    記述言語：英語  

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  • Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles 査読

    Kentaro Otani, Kenichi Yamahara, Shunsuke Ohnishi, Hiroaki Obata, Soichiro Kitamura, Noritoshi Nagaya

    Journal of Controlled Release   133 ( 2 )   146 - 153   2009年1月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    DOI： 10.1016/j.jconrel.2008.09.088

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  • CONTRAST SONOGRAPHY ENABLES NONINVASIVE AND QUANTITATIVE ASSESSMENT OF NEOVASCULARIZATION AFTER STEM CELL TRANSPLANTATION 査読

    Kentaro Otani, Shunsuke Ohnishi, Hiroaki Obata, Osamu Ishida, Soichiro Kitamura, Noritoshi Nagaya

    ULTRASOUND IN MEDICINE AND BIOLOGY   34 ( 12 )   1893 - 1900   2008年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.ultrasmedbio.2008.04.014

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  • Novel sustained-release prostacyclin analog attenuates pulmonary hypertension in rats 査読

    Hiroaki Obata, Yoshiki Sakai, Shunsuke Ohnishi, Makoto Kodama, Yoshifusa Aizawa, Noritoshi Nagaya

    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   45   S26 - S26   2008年10月

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  • Transplantation of Mesenchymal Stem Cells Improves Atrioventricular Conduction in a Rat Model of Complete Atrioventricular Block 査読

    Miki Yokokawa, Shunsuke Ohnishi, Hatsue Ishibashi-Ueda, Hiroaki Obata, Kentaro Otani, Yoshinori Miyahara, Koichi Tanaka, Wataru Shimizu, Kazuo Nakazawa, Kenji Kangawa, Shiro Kamakura, Soichiro Kitamura, Noritoshi Nagaya

    CELL TRANSPLANTATION   17 ( 10-11 )   1145 - 1155   2008年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.3727/096368908787236594

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  • Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats 査読

    Takefumi Itoh, Hiroaki Obata, Shinsuke Murakami, Kaoru Hamada, Kenji Kangawa, Hiroshi Kimura, Noritoshi Nagaya

    American Journal of Physiology-Lung Cellular and Molecular Physiology   293 ( 2 )   L446 - L452   2007年8月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：American Physiological Society  

    Adrenomedullin (AM), an endogenous peptide, has been shown to have a variety of protective effects on the cardiovascular system. However, the effect of AM on acute lung injury remains unknown. Accordingly, we investigated whether AM infusion ameliorates lipopolysaccharide (LPS)-induced acute lung injury in rats. Rats were randomized to receive continuous intravenous infusion of AM (0.1 μg·kg<sup>−1</sup>·min<sup>−1</sup>) or vehicle through a microosmotic pump. The animals were intratracheally injected with either LPS (1 mg/kg) or saline. At 6 and 18 h after intratracheal instillation, we performed histological examination and bronchoalveolar lavage and assessed the lung wet/dry weight ratio as an index of acute lung injury. Then we measured the numbers of total cells and neutrophils and the levels of tumor necrosis factor (TNF)-α and cytokine-induced neutrophil chemoattractant (CINC) in bronchoalveolar lavage fluid (BALF). In addition, we evaluated BALF total protein and albumin levels as indexes of lung permeability. LPS instillation caused severe acute lung injury, as indicated by the histological findings and the lung wet/dry weight ratio. However, AM infusion attenuated these LPS-induced abnormalities. AM decreased the numbers of total cells and neutrophils and the levels of TNF-α and CINC in BALF. AM also reduced BALF total protein and albumin levels. In addition, AM significantly suppressed apoptosis of alveolar wall cells as indicated by cleaved caspase-3 staining. In conclusion, continuous infusion of AM ameliorated LPS-induced acute lung injury in rats. This beneficial effect of AM on acute lung injury may be mediated by inhibition of inflammation, hyperpermeability, and alveolar wall cell apoptosis.

    DOI： 10.1152/ajplung.00412.2005

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  • CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis 査読

    Hiroaki Obata, Bobby Yanagawa, Koichi Tanaka, Shunsuke Ohnishi, Masaharu Kataoka, Yoshinori Miyahara, Hatsue Ishibashi-Ueda, Makoto Kodama, Yoshifusa Aizawa, Kenji Kangawa, Noritoshi Nagaya

    Biochemical and Biophysical Research Communications   356 ( 1 )   60 - 66   2007年4月

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    担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    DOI： 10.1016/j.bbrc.2007.02.085

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  • Single administration of a novel sustained-release prostacyclin analogue attenuates monocrotaline-induced pulmonary hypertension in rats 査読

    Hiroaki Obata, Yoshiki Sakai, Shunsuke Ohnishi, Satoshi Takeshita, Hidezo Mori, Makoto Kodama, Yoshifusa Aizawa, Noritoshi Nagaya

    CIRCULATION   114 ( 18 )   83 - 83   2006年10月

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    記述言語：英語  

    Web of Science

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  • Transplantation of mesenchymal stem cells improves atrioventricular conduction in a rat model of complete atrioventricular block 査読

    Miki Yokokawa, Shunsuke Ohnishi, Hatsue Ishibashi-Lieda, Masashi Inagaki, Hiroaki Obata, Yoshinori Miyahara, Koichi Tanaka, Wataru Shimizu, Kenji Kangawa, Shiro Kamakura, Soichiro Kitamura, Noritoshi Nagaya

    CIRCULATION   114 ( 18 )   80 - 80   2006年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.3727/096368908787236594

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  • Familial amyotrophic lateral sclerosis with bulbar onset and a novel Asp101Tyr Cu/Zn superoxide dismutase gene mutation 査読

    Chun-Feng Tan, Yue-Shan Piao, Shintaro Hayashi, Hiroaki Obata, Yoshitaka Umeda, Masahisa Sato, Takao Fukushima, Ryoichi Nakano, Shoji Tsuji, Hitoshi Takahashi

    Acta Neuropathologica   108 ( 4 )   332 - 336   2004年7月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

    DOI： 10.1007/s00401-004-0893-4

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    その他リンク： http://link.springer.com/article/10.1007/s00401-004-0893-4/fulltext.html

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