Updated on 2025/06/29

写真a

 
WATANABE Kanako
 
Organization
Academic Assembly Institute of Medicine and Dentistry Health Sciences Associate Professor
Graduate School of Health Sciences Health Sciences Associate Professor
Faculty of Medicine School of Health Sciences Medical Technology Associate Professor
Title
Associate Professor
External link

Degree

  • 博士（医学） ( 2007.9   新潟大学 )

Research Interests

  • ウイルス受容体

  • ヒトパレコウイルス

  • 感染症

  • ウイルス

  • パレコウイルスA

Research Areas

  • Life Science / Virology

  • Life Science / Embryonic medicine and pediatrics

Research History (researchmap)

  • Niigata University   Associate Professor

    2013.4

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  • Niigata University   Graduate School of Health Sciences Health Sciences   Associate Professor

    2013.4

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  • Niigata University   Faculty of Medicine School of Health Sciences Medical Technology   Associate Professor

    2013.4

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  • Niigata Prefectural Institute of Public Health And Environmental Sciences   Chief Researcher

    2011.4 - 2013.3

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Research History

  • Niigata University   Graduate School of Health Sciences Health Sciences   Associate Professor

    2013.4

  • Niigata University   Faculty of Medicine School of Health Sciences Medical Technology   Associate Professor

    2013.4

Education

  • Niigata University   医歯学総合研究科   地域疾病制御医学専攻

    - 2007.9

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Professional Memberships

 

Papers

  • Sustained Maternal Antibodies Against Parechovirus-A3 During the Coronavirus Disease 2019 Pandemic. Reviewed International journal

    Jun Tachikawa, Yuta Aizawa, Kanako Watanabe, Kazufumi Haino, Koji Nishijima, Akihiko Saitoh

    Journal of medical virology   97 ( 4 )   e70313   2025.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    The epidemiology of parechovirus-A3 (PeV-A3) infection in neonates and young infants changed during the coronavirus disease 2019 (COVID-19) pandemic. We hypothesized the pandemic impacted maternal antibodies against PeV-A3. To test this hypothesis, we measured neutralizing antibody titers (NATs) against PeV-A3 in 102 cord blood samples from full-term infants born in June-December 2023 at Niigata University Hospital in Niigata, Japan. Maternal data were collected and compared the findings with our previous pre-pandemic data. The median maternal age was 34.5 years (range: 30-37 years). The geometric mean titer (GMT) against PeV-A3 was 98.4 (95% confidence interval [CI]: 61.7-156.8). The GMT for ages 25-34 years (184.6, n = 45) and 35-44 years (56.3, n = 51) sustained at the same level when we compared to age-matched pre-pandemic data for ages 16-24 years (336.5, n = 11, p = 0.84) and 25-34 years (31.9, n = 107, p = 0.14), respectively. By multivariable logistic regression analyses, maternal age ≤ 34 years was associated with higher seropositivity (adjusted odds ratio [aOR] 3.12, 95% CI 1.18-8.78, p = 0.03). Maternal NATs against PeV-A3 were sustained at the same level during the COVID-19 pandemic, indicating intra-pandemic maintenance of humoral immunity to PeV-A3 in women of childbearing age.

    DOI： 10.1002/jmv.70313

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  • Detection of parechovirus-A in hospitalized children with acute lower respiratory infection in Myanmar, 2017-2018. Reviewed International journal

    Jun Tachikawa, Yuta Aizawa, Tetsuya Kobayashi, Tatsuki Ikuse, Kazuhiro Kamata, Su Mon Kyaw Win, Lasham Di Ja, Khin Nyo Thein, Nay Chi Win, Aye Thida, Aye Tun, Yuko Suzuki, Ai Ito, Hidekazu Osada, Irina Chon, Wint Wint Phyu, Tomomi Ota, Yadanar Kyaw, Htay Htay Tin, Kanako Watanabe, Yugo Shobugawa, Hisami Watanabe, Reiko Saito, Akihiko Saitoh

    Journal of medical virology   95 ( 7 )   e28964   2023.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    Parechovirus-A (PeV-A) causes emerging infection in children, and clinical presentation depends on genotype. The virus has been investigated mainly in developed countries; however, data from developing countries, especially in Asia, are sparse. This study investigated whether PeV-A circulated in children in Myanmar. This retrospective study evaluated PeV-A in nasopharyngeal samples from children aged 1 month to 12 years who were hospitalized with acute lower respiratory infection at Yankin Children Hospital, Yangon, Myanmar, during the period from May 2017 to April 2019. Real-time polymerase chain reaction (PCR) was used to detect PeV-A, and PCR-positive samples were used for genotyping and phylogenetic analysis. In total, 11/570 (1.9%) of samples were positive for PeV-A; 7 were successfully genotyped by sequencing the VP3/VP1 region, as follows: PeV-A1 (n = 4), PeV-A5 (n = 1), PeV-A6 (n = 1), and PeV-A14 (n = 1). Median age was 10.0 months (interquartile range 4.0-12.0 months), and other respiratory viruses were detected in all cases. Phylogenetic analysis showed that all detected PeV-A1 strains were in clade 1 A, which was a minor clade worldwide. Four PeV-A genotypes were detected in Myanmar. The clinical impact of PeV-A in children should be evaluated in future studies.

    DOI： 10.1002/jmv.28964

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  • Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry Reviewed

    Kanako Watanabe, Tomoichiro Oka, Hirotaka Takagi, Sergei Anisimov, Shun-ichi Yamashita, Yoshinori Katsuragi, Masahiko Takahashi, Masaya Higuchi, Tomotake Kanki, Akihiko Saitoh, Masahiro Fujii

    Nature Communications   14 ( 1 )   2023.3

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Human parechovirus (PeV-A) is an RNA virus that belongs to the family Picornaviridae and it is currently classified into 19 genotypes. PeV-As usually cause mild illness in children and adults. Among the genotypes, PeV-A3 can cause severe diseases in neonates and young infants, resulting in neurological sequelae and death. In this study, we identify the human myeloid-associated differentiation marker (MYADM) as an essential host factor for the entry of six PeV-As (PeV-A1 to PeV-A6), including PeV-A3. The infection of six PeV-As (PeV-A1 to PeV-A6) to human cells is abolished by knocking out the expression of MYADM. Hamster BHK-21 cells are resistant to PeV-A infection, but the expression of human MYADM in BHK-21 confers PeV-A infection and viral production. Furthermore, VP0 capsid protein of PeV-A3 interacts with one extracellular domain of human MYADM on the cell membrane of BHK-21. The identification of MYADM as an essential entry factor for PeV-As infection is expected to advance our understanding of the pathogenesis of PeV-As.

    DOI： 10.1038/s41467-023-37399-8

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    Other Link： https://www.nature.com/articles/s41467-023-37399-8

  • 福岡県・大分県からの新生児・早期乳児のパレコウイルスA3感染症の症例集積の報告

    相澤 悠太, 太刀川 潤, 幾瀬 樹, 羽深 理恵, 齋藤 昭彦, 渡邉 香奈子, 諸岡 雄也, 古野 憲司, 朴 崇娟, 水野 由美, 川口 直樹, 原 卓也, 砂川 富正

    病原微生物検出情報月報   43 ( 10 )   234 - 235   2022.10

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    Language：Japanese   Publisher：国立感染症研究所  

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  • Molecular Evolution and Epidemiology of Parechovirus-A3 in Japan, 1997-2019. Reviewed International journal

    Yuta Aizawa, Takuhiro Kasamatsu, Koo Nagasawa, Kanako Watanabe, Akihiko Saitoh

    The Journal of infectious diseases   227 ( 2 )   288 - 294   2022.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    Parechovirus-A3 (PeV-A3), first reported in 2004 in Japan, is an emerging pathogen that causes sepsis and meningoencephalitis in neonates and young infants. Although PeV-A3 has been identified worldwide, its epidemiological characteristics differ by region. To investigate the molecular evolution and epidemiology of PeV-A3, we performed genetic analyses of 131 PeV-A3 strains from the years 1997-2019 in Niigata, Japan. During 2016-2019, annual numbers remained steady, in contrast to the PeV-A3 epidemic interval of every 2-3 years that was observed in Japan from 2006. Bayesian evolutionary analysis of the complete viral protein 1 region revealed alternate dominant clusters during years of PeV-A3 epidemics. The branch including the oldest and first isolated PeV-A3 strains in Japan has been disrupted since 2001. The year of PeV-A3 emergence was estimated to be 1991. Continuous surveillance with genetic analyses of different regions will improve understanding of PeV-A3 epidemiology worldwide.

    DOI： 10.1093/infdis/jiac213

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  • Development of Novel PCR Assays for Improved Detection of Enterovirus D68. Reviewed International journal

    Tatsuki Ikuse, Yuta Aizawa, Hayato Takihara, Shujiro Okuda, Kanako Watanabe, Akihiko Saitoh

    Journal of clinical microbiology   59 ( 11 )   JCM0115121   2021.8

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    Enterovirus D68 (EV-D68) causes a range of clinical manifestations, including asthma-like illness, severe respiratory disease, and acute flaccid myelitis. EV-D68 has caused worldwide outbreaks since 2014 and is now recognized as a re-emerging infection in many countries. EV-D68-specific PCR assays are widely used for the diagnosis of EV-D68 infection; however, assay sensitivity is a concern because of genetic changes in recently circulated EV-D68. To address this, we summarized EV-D68 sequences from previously reported world outbreaks from 2014 through 2020 on GenBank, and found several mutations at the primer and probe binding sites of the existing EV-D68-specific PCR assays. Subsequently, we designed two novel assays corresponding to the recently reported EV-D68 sequences: an EV-D68-specific real-time and semi-nested PCR. In an analysis of 22 EV-D68-confirmed cases during a recent EV-D68 outbreak in Japan, the new real-time PCR had higher sensitivity than the existing assay (100% vs. 45%, P < 0.01) and a lower median Ct value (27.8 vs. 32.8, P = 0.005). Sensitivity was higher for the new non-nested PCR (91%) than for the existing semi-nested PCR assay (50%, P < 0.01). The specificity of the new real-time PCR was 100% using samples from non-EV-D68-infected cases (n = 135). In conclusion, our novel assays had higher sensitivity than the existing assay and might lead to more accurate diagnosis of recently circulating EV-D68. To prepare for future EV-D68 outbreaks, EV-D68-specific assays must be continuously monitored and updated.

    DOI： 10.1128/JCM.01151-21

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  • PCR detection rates for serum and cerebrospinal fluid from neonates and young infants infected with human parechovirus 3 and enteroviruses Reviewed International journal

    Yuko Suzuki, Yuta Aizawa, Ryohei Izumita, Rie Habuka, Kanako Watanabe, Akihiko Saitoh

    Journal of Clinical Virology   135   104736 - 104736   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    BACKGROUND: Human parechovirus 3 (HPeV-3) and enteroviruses (EV) are commonly detected viruses in febrile neonates and young infants and are usually diagnosed by PCR. However, in this population, data on detection rates for samples from different anatomical sites are limited. OBJECTIVES: To determine PCR detection rates for HPeV-3 and EVs in serum and cerebrospinal fluid (CSF) samples from febrile neonates and young infants. STUDY DESIGN: This prospective study identified viruses in serum and CSF samples collected from febrile neonates and young infants (age <4 months) in Niigata, Japan, during 2014-2018. HPeV-3 or EV infection was defined as a positive quantitative real-time PCR result for the virus in serum or CSF. Genotypes were identified by sequence analyses of the viral protein 1 region. RESULTS: Among 216 patients, we identified 56 HPeV-3-infected (26 %) and 48 EV-infected patients (22 %). All (56/56; 100 %) HPeV-3-infected patients had a positive PCR result for serum, and 49/56 (88 %) had a positive result for CSF. In EV-infected patients, 40/48 (83 %) were positive for serum, and 34/48 (71 %) were positive for CSF, and 22/48 (46 %) were positive for serum (n = 14) or CSF (n = 8). If only a CSF sample had been obtained, 7 (12 %) HPeV-3 infections and 14 (29 %) EV infections would have been undiagnosed. Detection rates in serum and CSF differed by genotype in EV-infected patients. CONCLUSIONS: Viral RNA detection rates differed between serum and CSF in HPeV-3- and EV-infected neonates/infants. Combined evaluation of serum and CSF samples is important for accurate viral diagnosis in this population.

    DOI： 10.1016/j.jcv.2021.104736

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  • Outbreak of Enterovirus D68 Among Children in Japan—Worldwide Circulation of Enterovirus D68 Clade B3 in 2018 Reviewed International journal

    Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh

    Pediatric Infectious Disease Journal   40 ( 1 )   6 - 10   2021.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

    BACKGROUND: Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred in the United States in 2014. We experienced an accumulation of pediatric cases with asthma-like respiratory illness in Niigata, Japan, in 2018. STUDY DESIGN: To determine whether EV-D68 was responsible for the case accumulation, this prospective observational study evaluated children hospitalized in 1 of 8 hospitals with asthma-like respiratory illness in Niigata, Japan, during October and November 2018. Diagnoses were made by EV-D68-specific RT-PCR using nasopharyngeal samples. The clade was identified by sequence analyses, and a phylogenetic tree was created. To evaluate seasonal variation, data from pediatric cases with asthma-like respiratory illness in 2018 were retrospectively analyzed. RESULTS: In 2018, 114 children were hospitalized with asthma-like respiratory illness in October and November, and 47 nasopharyngeal samples were collected. EV-D68 was detected in 22/47 (47%) patients during the study period. The phylogenetic tree revealed that all strains belonged to the clade B3 branch, which has been detected worldwide every 2 years since 2014. CONCLUSIONS: EV-D68 was the associated pathogen for asthma-like respiratory illness in children in Japan in 2018. Clade B3, the dominant clade in outbreaks worldwide, was responsible for the outbreak. Detection and detailed virologic analysis of EV-D68 is important as part of worldwide surveillance, as it will aid in understanding the epidemiologic characteristics of EV-D68 infection.

    DOI： 10.1097/inf.0000000000002889

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  • Novel scoring system for differentiating parechovirus-A3 and enterovirus infection in neonates and young infants. Reviewed International journal

    Ryohei Izumita, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Nobutaka Kitamura, Kohei Akazawa, Akihiko Saitoh

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology   124   104256 - 104256   2020.3

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    BACKGROUND: Parechovirus-A3 (PeV-A3) and the enteroviruses (EVs) are the most common viral pathogens responsible for sepsis and meningoencephalitis in neonates and young infants; however, differences in the clinical presentations of two infections are not well described. OBJECTIVES: To describe the clinical presentations of PeV-A3- and EVs-related diseases and develop a novel scoring system to differentiate two diseases. STUDY DESIGN: This prospective study used real-time PCR and genetic sequencing to evaluate viral etiologies of febrile neonates and infants <4 months with suspected sepsis or meningoencephalitis in Niigata area, Japan, in 2014-2016. The clinical manifestations of PeV-A3- and EVs-infected patients were compared, and a novel scoring system was developed after identifying the most distinguishable clinical findings, followed by the external cohort validation. RESULTS: In 210 patients evaluated, we identified 56 PeV-A3-infected (27%) and 43 EVs-infected (20%) patients. The following clinical manifestations were significant in PeV-A3-infected patients, as compared with EVs-infected patients; a higher body temperature (38.9°C vs. 38.5°C, P < .01) and heart rate (181/min vs. 168/min, P = .01), cold extremities (72% vs. 34%, P < .01) and skin mottling (65% vs. 23%, P < .01), lower white blood cell count (5,200/μL vs. 8,900/μL, P < .01) and incidence of cerebrospinal fluid (CSF) pleocytosis (2% vs. 63%, P < .01). Using some of these significant findings, the scoring system successfully distinguished the diseases (accuracy: 86% and 83% for the derivative and external validation cohorts, respectively). CONCLUSIONS: We found significant clinical manifestations in PeV-A3-infected patients compared to EVs-infected patients. The scoring system may be helpful to distinguish two infections, especially at onset of outbreak.

    DOI： 10.1016/j.jcv.2019.104256

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  • Intrafamilial Transmission of Parechovirus A and Enteroviruses in Neonates and Young Infants. Reviewed International journal

    Ryohei Izumita, Kazuki Deuchi, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh

    Journal of the Pediatric Infectious Diseases Society   8 ( 6 )   501 - 506   2019.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press  

    BACKGROUND: Parechovirus A (PeV-A) is an important cause of sepsis and meningoencephalitis in neonates and young infants. Thus, identifying the source of PeV-A is essential for prevention; however, little is known regarding the spread of PeV-A among family members of PeV-A-infected neonates and young infants. METHODS: In this prospective study, we evaluated stool samples from family members of PeV-A-infected neonates and infants younger than 4 months who presented with sepsis, meningoencephalitis, or both in Niigata, Japan, in 2016. Because of a simultaneous outbreak, enteroviruses (EVs) were also evaluated during this period. Real-time polymerase chain reaction followed by sequence analysis was used for viral diagnosis using serum and/or cerebrospinal fluid samples. RESULTS: Among 54 febrile patients, the stool samples of 14 (26%) and 12 (22%) patients tested positive for PeV-A and EV, respectively. Stool samples from 54 family members (38 adults and 16 children) of 12 PeV-A-infected patients were available. The rate of PeV-A positivity in these samples was higher among the children (88% [14 of 16]) than the adults (34% [13 of 38]). Among family members with a PeV-A-positive stool sample, 29% (4 of 14) of the children and 77% (10 of 13) of the adults were asymptomatic. Similarly, among 53 stool samples from family members (31 adults and 22 children) of 11 EV-infected patients, the rate of EV positivity in the stool samples was higher among the children (91% [20 of 22]) than among the adults (42% [13 of 31]). The asymptomatic-patient rates were 45% (9 of 20) among the children and 85% (11 of 13) among the adults in family members with EV-positive stool. CONCLUSIONS: Similar to EVs, PeV-A was detected frequently in stool samples from family members of PeV-A-infected patients. Among family members with PeV-A-positive stool, adults were more likely than children to be asymptomatic and therefore could be an important source of PeV-A infection.

    DOI： 10.1093/jpids/piy079

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  • Persistence of High Neutralizing Antibody Titers After Neonatal and Early Infantile Infection with Parechovirus-A3. Reviewed International journal

    Ryohei Izumita, Yuta Aizawa, Kanako Watanabe, Akihiko Saitoh

    The Pediatric infectious disease journal   38 ( 7 )   e159-e161   2019.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    This 3-year follow-up study evaluated neutralizing antibody titers (NATs) against parechovirus-A3 (PeV-A3) in neonates and young infants who developed PeV-A3 infection. All children had low NATs at disease onset and high NATs after infection during infancy. At age 3 years, all 16 patients tested had high NATs (≥1:512) against PeV-A3 indicating that specific PeV-A3 NATs persist into childhood.

    DOI： 10.1097/INF.0000000000002245

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  • Comparability between Durham method and real-time monitoring for long-term observation of Japanese cedar (Cryptomeria japonica) and Japanese cypress (Cryptomeria obtusa) pollen counts in Niigata prefecture, Japan Reviewed

    Kanako Watanabe, Tsuyoshi Ohizumi

    Aerobiologia   34 ( 2 )   257 - 267   2018.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Netherlands  

    DOI： 10.1007/s10453-018-9511-0

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  • Seropositivity and epidemiology of human parechovirus types 1, 3, and 6 in Japan Reviewed

    Kanako Watanabe, Chika Hirokawa, Takashi Tazawa

    EPIDEMIOLOGY AND INFECTION   144 ( 16 )   3451 - 3460   2016.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1017/S0950268816001795

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  • Clinical utility of serum samples for human parechovirus type 3 infection in neonates and young infants: The 2014 epidemic in Japan Reviewed

    Yuta Aizawa, Yuko Suzuki, Kanako Watanabe, Tomohiro Oishi, Akihiko Saitoh

    JOURNAL OF INFECTION   72 ( 2 )   223 - 232   2016.2

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    DOI： 10.1016/j.jinf.2015.10.010

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  • Nephrotic Syndrome without Hematuria due to Infection-Related Glomerulonephritis Mimicking Minimal-Change Disease in a Child Reviewed

    Yoichi Iwafuchi, Tetsuo Morioka, Takashi Morita, Kanako Watanabe, Yuko Oyama, Ichiei Narita

    Case Reports in Nephrology and Dialysis   6 ( 1 )   14 - 20   2016

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：S. Karger AG  

    DOI： 10.1159/000443727

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  • Role of Maternal Antibodies in Infants with Severe Diseases Related to Human Parechovirus Type 3 Reviewed

    Yuta Aizawa, Kanako Watanabe, Tomohiro Oishi, Harunobu Hirano, Isao Hasegawa, Akihiko Saitoh

    EMERGING INFECTIOUS DISEASES   21 ( 11 )   1966 - 1972   2015.11

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    DOI： 10.3201/eid2111.150267

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  • Asymptomatic children might transmit human parechovirus type 3 to neonates and young infants Reviewed

    Yuta Aizawa, Takayuki Yamanaka, Kanako Watanabe, Tomohiro Oishi, Akihiko Saitoh

    JOURNAL OF CLINICAL VIROLOGY   70   105 - 108   2015.9

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    DOI： 10.1016/j.jcv.2015.07.300

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  • Detection of extended spectrum β-lactamase producing <i>Escherichia coli</i> (ESBL <i>E. coli</i>) from chicken meat in Niigata prefecture, Japan Reviewed

    Holipitige Pubuduni, Sugandhika Bandara,Marcello, Otake Sato, Megumi Sato, Lalani Yatawara, Kanako Watanabe

    新潟大学保健学雑誌   12 ( 1 )   65 - 68   2015.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：新潟大学医学部保健学科  

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    Other Link： http://hdl.handle.net/10191/38952

  • 新潟県における新型インフルエンザ流行期とその後の呼吸器ウイルス検出状況 Reviewed

    昆美也子, 渡部香, 田澤崇, 広川智香, 渡邉香奈子

    医学検査   61 ( 3 )   548 - 554   2012.5

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本臨床衛生検査技師会  

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  • Detection of Human Coronavirus NL63 and 0C43 in Children with Acute Respiratory Infections in Niigata, Japan, between 2010 and 2011

    Miyako Kon, Kaori Watanabe, Takashi Tazawa, Kanako Watanabe, Tsutomu Tamura, Hiroyuki Tsukagoshi, Masahiro Noda, Hirokazu Kimura, Katsumi Mizuta

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   65 ( 3 )   270 - 272   2012.5

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    DOI： 10.7883/yoken.65.270

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  • Imported Cases of Measles in Niigata, Japan in 2011

    Kanako Watanabe, Kaori Watanabe, Takashi Tazawa, Miyako Kon, Tsutomu Tamura, Katsuhiro Komase

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   65 ( 3 )   268 - 270   2012.5

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    DOI： 10.7883/yoken.65.268

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  • An Outbreak of Food Poisoning Due to Enterohemorrhagic Escherichia coli O157 in Niigata, Japan

    Kanako Watanabe, Akiko Murayama, Naomi Kogure, Masao Kawase, Yuki Kimura

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   63 ( 2 )   146 - 147   2010.3

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  • Short Report: Chikungunya Virus Isolated from a Returnee to Japan from Sri Lanka: Isolation of Two Sub-Strains with Different Characteristics Reviewed

    Chang-Kweng Lim, Takeaki Nishibori, Kanako Watanabe, Mikako Ito, Akira Kotaki, Keiko Tanaka, Ichiro Kurane, Tomohiko Takasaki

    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE   81 ( 5 )   865 - 868   2009.11

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    DOI： 10.4269/ajtmh.2009.09-0009

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  • Estimation of focus reduction neutralization test for measurement of neutralizing antibody titer against Japanese encephalitis virus

    Kanako Watanabe, Chika Hirokawa, Miyako Kon, Tsutomu Tamura, Makoto Nishikawa

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   61 ( 5 )   424 - 425   2008.9

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  • Identification and characterization of two strains of human Parechovirus 4 isolated from two clinical cases in Fukuoka city, Japan Reviewed

    Kiyoko Wakatsuki, Daisuke Kawamoto, Hiroshi Hiwaki, Kanako Watanabe, Hiromu Yoshida

    JOURNAL OF CLINICAL MICROBIOLOGY   46 ( 9 )   3144 - 3146   2008.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1128/JCM.00791-08

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  • Isolation and characterization of novel human parechovirus from clinical samples Reviewed

    Kanako Watanabe, Masayasu Oie, Masaya Higuchi, Makoto Nishikawa, Masahiro Fujii

    EMERGING INFECTIOUS DISEASES   13 ( 6 )   889 - 895   2007.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3201/eid1306.060896

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  • Performance and quality assurance of genotypic drug-resistance testing for human immunodeficiency virus type 1 in Japan

    Seiichiro Fujisaki, Saeko Fujisaki, Shiro Ibe, Tsukasa Asagi, Toshihiro Itoh, Shigeru Yoshida, Takao Koike, Masayasu Oie, Makiko Kondo, Kenji Sadamasu, Mami Nagashima, Hiroyuki Gatanaga, Masakazu Matsuda, Mikio Ueda, Aki Masakane, Mami Hata, Yasushi Mizogami, Haruyo Mori, Rumi Minami, Kiyomi Okada, Kanako Watanabe, Takuma Shirasaka, Shinichi Oka, Wataru Sugiura, Tsuguhiro Kaneda

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   60 ( 2-3 )   113 - 117   2007.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    Web of Science

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  • Surveillance of poliovirus - isolates in Japan, 2002

    Hiroyuki Shumuzu, Hiromu Yoshida, Utama Andy, Takashi Nakayama, Takayuki Saito, Kanako Watanabe, Setsuko Iizuka, Shinji Noda, Tetsuo Yoneyama, Tatsuo Miyamura

    Japanese Journal of Infectious Diseases   56 ( 5-6 )   218 - 219   2003.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：National Institute of Infectious Diseases  

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  • Surveillance of poliovirus - isolates in Japan, 1999

    Tetsuo Yoneyama, Yosiaki Kro, Kanako Watanabe, Misako Tsuchiya, Mamoru Nakano, Tatsuo Miyamura

    Japanese Journal of Infectious Diseases   53 ( 2 )   90 - 91   2000.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：National Institute of Infectious Diseases  

    CiNii Article

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Books

  • 菌ウイルス寄生虫便覧

    泉對 博, 竹原 一明, 渡邉 香奈子（ Role： Joint author）

    技術情報協会  2014.3  （ ISBN:9784861045011 ）

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    Language：Japanese

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MISC

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Research Projects

  • Establishment of a mouse model of human parechovirus A3 infection and elucidation of the mechanism of severe infection

    Grant number：25K02621

    2025.4 - 2029.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\18850000 （ Direct Cost: \14500000 、 Indirect Cost：\4350000 ）

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  • 異所性のDNAがもたらす老化・加齢関連疾患・感染症病態の網羅的比較解析

    Grant number：22H00501

    2022.4 - 2027.3

    System name：科学研究費助成事業

    Research category：基盤研究(A)

    Awarding organization：日本学術振興会

    松井 秀彰, 垣花 太一, 渡邉 香奈子

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    Grant amount：\41860000 （ Direct Cost: \32200000 、 Indirect Cost：\9660000 ）

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  • Parechovirus A3 Infection in Children -Investigation of Epidemics in the World, and Influencing and Severity Factors-

    Grant number：21KK0166

    2021.10 - 2027.3

    System name：Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    Research category：Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\18980000 （ Direct Cost: \14600000 、 Indirect Cost：\4380000 ）

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  • 子育て期早期の母親と父親の「睡眠負債」に迫る―健康促進はどのように実現できるかー

    Grant number：20K21703

    2020.7 - 2023.3

    System name：科学研究費助成事業 挑戦的研究(萌芽)

    Research category：挑戦的研究(萌芽)

    Awarding organization：日本学術振興会

    関島 香代子, 渡邉 香奈子, 定方 美恵子, 清水 悦子, 関島 恒夫

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    Grant amount：\6240000 （ Direct Cost: \4800000 、 Indirect Cost：\1440000 ）

    本研究は、身体の不調が引き起こすメンタルの不調（産後うつ等）が児童虐待、養育不全（ネグレクト）のリスク（健やか親子２１（第二次））であることから、子育て期においてそれらを予防／健康増進することにより健やかな子どもの成長を支える方策を検討する。心身の不調を回復するために必要不可欠な睡眠が、両親と児の三者が相互に作用している状態を捉え、「睡眠負債」を生じさせない方略を検討することを目的としている。子育て期は、子どもの出生直後の、新たな親役割を果たすべく試行錯誤する時期から、その後の長期にわたり、子どもの発達とともに求められる親役割の変化、それにあわせて生活状態・睡眠状態の変化を試行錯誤していく。その中で、「睡眠」にはどのような相互作用があるのか／母親の睡眠不足と父親の睡眠不足はどのように解消されているのか、疲労回復が不十分な状態がどのくらい継続しているのか／「睡眠負債」がどのような影響を及ぼしているのか、どのような状況が睡眠の充足につながるかについて、検討する。
    当初、乳児期の子どもをもつ両親を対象とした睡眠状態に関する縦断的観察研究（研究1）と子育て期を終えた女性の横断的健康調査（研究2）を計画したが、研究協力者を確保するために考えていた各施設と研究代表者／研究分担者所属機関が、コロナ感染症拡大への対応がとられる中、研究1について研究方法の見直しが随時に迫られ、計画通りの遂行が困難になった。遅れながらも、倫理委員会受審、承認を得ることができた。対象者募集まで進めた。研究2については、調査内容を見直し、倫理委員会の受審の準備が整った。

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  • Identification of receptors for human parechovirus type 3 and elucidation of the mechanism of severe infection

    Grant number：19K08294

    2019.4 - 2022.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Investigations for Effective Therapies for Human Parechovirus Type 3 Infection

    Grant number：17H04226

    2017.4 - 2020.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

    Saitoh Akihiko

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    Grant amount：\16900000 （ Direct Cost: \13000000 、 Indirect Cost：\3900000 ）

    There has been no specific treatment for parechovirus-A3 (PeV-A3) infection, which causes severe infection in neonates and young infants. We evaluated the effectiveness of antimicrobials for PeV-A3 using in vitro models. As a results, we found inhibition effects of soem antimicrobials for PeV-A3. These medications could lead to the future treatment strategies for PeV-A3 infection.

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  • Mechanisms of Onset of Human Parechovirus Type 3 Infection in Neonates -A role of Transfer Antibodies-

    Grant number：26461569

    2014.4 - 2017.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Saitoh Akihiko, Aizawa Yuta

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    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    Human parechovirus type 3 (HPeV3) is an emerging infection causing sepsis and meningoencephalitis in neonates and young infants. To understand the pathogenesis of HPeV3 infection, we measured 1) neutralizing antibody titers to HPeV1, HPeV3, and HPeV6 in cord blood samples from term infants and 2) 45 neonates and young infants diagnosed as having severe HPeV3-related diseases. As results, antibodies to HPeV1, HPeV3, and HPeV6 in cord blood samples were similar among 3 types (P = 0.17), and 40% of samples was low titers against HPeV3. Among the patients, 42/45 (93%) had a neutralizing antibody titer to HPeV3 <1:4, and the remaining 3/45 (7%) had low neutralizing antibody titers, ie, <1:16 at disease onset. Subsequent antibody titers increased to >1:512 in all patients who underwent follow-up examinations at ages 3 months and 6 months. These results indicate that transfer antibodies are important in neonates and young infants with severe HPeV3-related diseases.

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  • Health index among child rearing women as a social support strategy

    Grant number：26463373

    2014.4 - 2017.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Sekijima Kayoko, ISHIDA Mayumi, NISHIKATA Mayumi, OYA Noriko, HONDA Akira, HORII Emi, KODERA Yuri, PATHIRATHNA L. Malshani, TAKAHASHI Tomoe

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    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    The low birth rate has been pointed out and wrestled as a serious social health problem for a long time. There might be the difference between actual childcare situation and the social recognition. So, we aimed to be clarified hormonal conditions the physical health among mothers before and after childbirth, and sleep disturbance among mothers and her partners objectively and subjectively.
    As the results, majority of mothers unique hormonal conditions which had not recovered before pregnant state yet after six month of childbirth, much disturbed sleep had kept to after three month even in their partners at one month after childbirth. The need including the menstruation recovery of the woman after childbirth and the health condition of the partner became clear for a health index among early child rearing period that had been overlooked until now.

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  • The effects of estrogen and hepatic dendritic cells on the onset of autoimmune hepatitis.

    Grant number：26460643

    2014.4 - 2017.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Tomiyama Chikako, WATANABE Kanako, WATANABE Hisami

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    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    Autoimmune hepatitis is often found in middle-aged women whose estrogen level is low.Therefore, we investigated the effects of estrogen level on the onset or the progression of autoimmune hepatitis. We examined hepatic dendritic cells (DCs) with mice model. Our results showed that estrogen can suppress autoimmune liver injury because hepatic plasmacytoid DCs (pDCs) increase IL-10 production by estrogen receptor α chain. On the other hand, an estrogen blockade or an ovariectomy decreased such effects of estrogen. At the same time, hepatic myeloid DCs (mDCs) were activated and they increased production of IL-12p70 as well as TNFα. In this way, it is considered that estrogen affords the key to understand the onset of autoimmune hepatitis and its progression. From the view point of DCs, a shift of two types of hepatic DC subpopulations, pDCs or mDCs in the liver, could provide another clue to autoimmune hepatitis.

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Teaching Experience (researchmap)

  • Laws and Regulations Related to Medical Technologist

    2020.4

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  • Medical Safety Management

    2018.4

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  • Graduation Thesis

    2014.4

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  • Medical Microbiology

    2013.4

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  • Medical Microbiology Laboratory

    2013.4

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  • Clinical Microbiology

    2013.4

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  • Accuracy Management of Laboratory Medicine

    2013.4

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  • Clinical Practice of Medical Technology

    2013.4

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  • Comprehensive health sciences

    2013.4

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  • Clinical Microbiology Laboratory

    2013.4

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Teaching Experience

  • リサーチ・メソッズ・ベーシック

    2021
    Institution name：新潟大学

  • ゲノム・微生物病態検査科学特講演習

    2021
    Institution name：新潟大学

  • 保健学特定研究(検査技術科学)

    2021
    Institution name：新潟大学

  • ゲノム・微生物病態検査科学特講

    2021
    Institution name：新潟大学

  • 保健学総合

    2021
    Institution name：新潟大学

  • 医療英語ベーシック(検査)

    2021
    Institution name：新潟大学

  • 医療制度概論

    2020
    Institution name：新潟大学

  • 医療安全管理学

    2018
    Institution name：新潟大学

  • 医学検査管理総論

    2016
    Institution name：新潟大学

  • 臨床検査実習

    2016
    Institution name：新潟大学

  • 臨床検査管理概論

    2016
    -
    2018
    Institution name：新潟大学

  • 環日本海医療概論

    2015
    -
    2018
    Institution name：新潟大学

  • 保健学特別研究(検査技術科学)

    2014
    Institution name：新潟大学

  • 卒業研究

    2014
    Institution name：新潟大学

  • 病原微生物解析学実習

    2014
    Institution name：新潟大学

  • 国際病態検査科学概論

    2014
    Institution name：新潟大学

  • 病原微生物解析学特論

    2014
    Institution name：新潟大学

  • スタディスキルズ (検査)

    2014
    Institution name：新潟大学

  • 医療英語(検査)

    2014
    Institution name：新潟大学

  • 生命と生活の健康科学

    2014
    -
    2019
    Institution name：新潟大学

  • ゲノム・微生物病態検査学特講演習

    2014
    -
    2017
    Institution name：新潟大学

  • ゲノム・微生物病態検査学特講

    2014
    -
    2017
    Institution name：新潟大学

  • 医用工学実習

    2014
    Institution name：新潟大学

  • 病原微生物学

    2013
    Institution name：新潟大学

  • 微生物検査科学

    2013
    Institution name：新潟大学

  • 微生物検査科学演習

    2013
    Institution name：新潟大学

  • 病原微生物学実習

    2013
    Institution name：新潟大学

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