Updated on 2021/06/14

写真a

 
FUSIKI Mae
 
Organization
University Medical and Dental Hospital Center for Clinical Oncology Specially Appointed Assistant Professor
Title
Specially Appointed Assistant Professor
External link

Degree

  • 博士(医学) ( 2014.3   新潟大学 )

Research Areas

  • Others / Others

Research History

  • Niigata University   University Medical and Dental Hospital Center for Clinical Oncology   Specially Appointed Assistant Professor

    2016.4

  • Niigata University   University Medical and Dental Hospital Center for Clinical Oncology   Specially Appointed Assistant Professor

    2013.8 - 2015.3

 

Papers

  • RNF43 mutation is associated with aggressive tumor biology along with BRAF V600E mutation in right-sided colorectal cancer Reviewed

    Matsumoto A, Shimada Y, Nakano Mae, Oyanagi H, Tajima Y, Nakano Masato, Kameyama H, Hirose Y, Ichikawa H, Nagahashi M, Nogami H, Maruyama S, Takii Y, Ling Y, Okuda S, Wakai T

    Oncology Reports   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

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  • Feasibility of restorative proctocolectomy in patients with ulcerative colitis-associated lower rectal cancer: A retrospective study. Reviewed

    Hotta S, Shimada Y, Nakano M, Yamada S, Abe K, Oyanagi H, Yagi R, Tajima Y, Nakano M, Kameyama H, Nagahashi M, Sakata J, Kobayashi T, Wakai T

    Asian journal of surgery42 ( 1 ) 267 - 273   2019.1

  • [A Case of Long-Term Survival in a Patient with Ascending Colon Cancer and Synchronous Multiple Liver Metastases after Multimodality Therapy Including Multiple Hepatectomy]. Reviewed

    Hotta S, Kameyama H, Shimada Y, Yamada S, Tanaka K, Tajima Y, Nakano M, Ichikawa H, Hanyu T, Takizawa K, Nakano M, Nagahashi M, Sakata J, Kobayashi T, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy45 ( 13 ) 2464 - 2466   2018.12

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  • Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer Reviewed

    Kizuki Yuza, Masayuki Nagahashi, Yoshifumi Shimada, Mae Nakano, Yosuke Tajima, Hitoshi Kameyama, Masato Nakajima, Kazuaki Takabe, Toshifumi Wakai

    Journal of Surgical Research231   323 - 330   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Academic Press Inc.  

    Background: Colitis-associated cancer (CAC) is the most serious complication of inflammatory bowel disease. Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that is generated by sphingosine kinase 1 (SphK1) and is known to play an important role in inflammation and cancer progression. Moreover, SphK1 and S1P act as upstream mediators of proinflammatory cytokine interleukin 6 (IL-6) and signal transducer and activator of transcription-3 (STAT3). We hypothesized that the expression levels of phosphorylated SphK1 (pSphK1), phosphorylated STAT3 (pSTAT3), and IL-6 are universally higher in CAC patients than in sporadic colorectal cancer (CRC) patients because all of these factors are associated with inflammation. In this study, we determined the expression levels of pSphK1 in patients with sporadic CRC and CAC and clarified the importance of S1P in CAC patients. Materials and methods: We randomly selected 10 sporadic CRC patients and 10 CAC patients who underwent curative resection, and we examined their surgical specimens by immunohistochemistry. We determined the expression levels of pSphK1, pSTAT3, and IL-6 in these samples. Results: We found pSphK1 expression to be more prevalent in CAC patients (P = 0.019) and to have a higher immunohistochemistry score (P = 0.005) than in sporadic CRC patients. However, the expression of pSTAT3 and IL-6 did not differ between the patient groups. Conclusions: To our knowledge, this is the first report comparing pSphK1 expression levels in CAC with those in sporadic CRC. The high levels of pSphK1 expression in CAC suggest an important role of S1P in the disease process of CAC.

    DOI: 10.1016/j.jss.2018.05.085

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  • [Two Cases of Colorectal Cancer with SRC Amplification]. Reviewed

    Oyanagi H, Shimada Y, Yagi R, Tajima Y, Ichikawa H, Nakano M, Nakano M, Nagahashi M, Sakata J, Kameyama H, Kobayashi T, Nogami H, Maruyama S, Takii Y, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy44 ( 12 ) 1757 - 1759   2017.11

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  • [Quality of Life of Patients after Colorectal Cancer Surgery as Assessed Using EQ-5D-5L Scores]. Reviewed

    Kameyama H, Shimada Y, Yagi R, Yamada S, Hotta S, Tajima Y, Nakano M, Okamura T, Nakano M, Ichikawa H, Hanyu T, Nagahashi M, Sakata J, Kobayashi T, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy44 ( 12 ) 1083 - 1085   2017.11

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  • Prophylactic lateral pelvic lymph node dissection in stage IV low rectal cancer Reviewed

    Hiroshi Tamura, Yoshifumi Shimada, Hitoshi Kameyama, Ryoma Yagi, Yosuke Tajima, Takuma Okamura, Mae Nakano, Masato Nakano, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Shin-Ichi Kosugi, Hitoshi Nogami, Satoshi Maruyama, Yasumasa Takii, Toshifumi Wakai

    World Journal of Clinical Oncology8 ( 5 ) 412 - 419   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Baishideng Publishing Group Co., Limited  

    AIM: To assess the clinical significance of prophylactic lateral pelvic lymph node dissection (LPLND) in stage IV low rectal cancer. METHODS: We selected 71 consecutive stage IV low rectal cancer patients who underwent primary tumor resection, and enrolled 50 of these 71 patients without clinical LPLN metastasis. The patients had distant metastasis such as liver, lung, peritoneum, and paraaortic LN. Clinical LPLN metastasis was defined as LN with a maximum diameter of 10 mm or more on preoperative pelvic computed tomography scan. All patients underwent primary tumor resection, 27 patients underwent total mesorectal excision (TME) with LPLND (LPLND group), and 23 patients underwent only TME (TME group). Bilateral LPLND was performed simultaneously with primary tumor resection in LPLND group. R0 resection of both primary and metastatic sites was achieved in 20 of 50 patients. We evaluated possible prognostic factors for 5-year overall survival (OS), and compared 5-year cumulative local recurrence between the LPLND and TME groups. RESULTS: For OS, univariate analyses revealed no significant benefit in the LPLND compared with the TME group (28.7% vs 17.0%, P = 0.523)
    multivariate analysis revealed that R0 resection was an independent prognostic factor. Regarding cumulative local recurrence, the LPLND group showed no significant benefit compared with TME group (21.4% vs 14.8%, P = 0.833). CONCLUSION: Prophylactic LPLND shows no oncological benefits in patients with Stage IV low rectal cancer without clinical LPLN metastasis.

    DOI: 10.5306/wjco.v8.i5.412

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  • Utility of comprehensive genomic sequencing for detecting HER2-positive colorectal cancer Reviewed

    Yoshifumi Shimada, Ryoma Yagi, Hitoshi Kameyama, Masayuki Nagahashi, Hiroshi Ichikawa, Yosuke Tajima, Takuma Okamura, Mae Nakano, Masato Nakano, Yo Sato, Takeaki Matsuzawa, Jun Sakata, Takashi Kobayashi, Hitoshi Nogami, Satoshi Maruyama, Yasumasa Takii, Takashi Kawasaki, Kei-ichi Homma, Hiroshi Izutsu, Keisuke Kodama, Jennifer E. Ring, Alexei Protopopov, Stephen Lyle, Shujiro Okuda, Kohei Akazawa, Toshifumi Wakai

    HUMAN PATHOLOGY66   1 - 9   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:W B SAUNDERS CO-ELSEVIER INC  

    HER2-targeted therapy is considered effective for KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (CRC). In general, HER2 status is determined by the use of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). Comprehensive genomic sequencing (CGS) enables the detection of gene mutations and copy number alterations including KRAS mutation and HER2 amplification; however, little is known about the utility of CGS for detecting HER2-positive CRC. To assess its utility, we retrospectively investigated 201 patients with stage I-IV CRC. The HER2 status of the primary site was assessed using IHC and FISH, and HER2 amplification of the primary site was also assessed using CGS, and the findings of these approaches were compared in each patient. CGS successfully detected alterations in 415 genes including KRAS codon 12/13 mutation and HER2 amplification. Fifty-nine (29%) patients had a KRAS codon 12/13 mutation. Ten (5%) patients were diagnosed as HER2 positive because of HER2 MC 3+, and the same 10 (5%) patients had HER2 amplification evaluated using CGS. The results of HER2 status and HER2 amplification were completely identical in all 201 patients (P < .001). Nine of the 10 HER2-positive patients were KRAS 12/13 wild-type and were considered possible candidates for HER2-targeted therapy. CGS has the same utility as IHC and FISH for detecting HER2-positive patients who are candidates for HER2-targeted therapy, and facilitates precision medicine and tailor-made treatment. (C) 2017 The Authors. Published by Elsevier Inc.

    DOI: 10.1016/j.humpath.2017.02.004

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  • Crohn病における縫合不全のリスク因子の検討 Reviewed

    岡村 拓磨, 亀山 仁史, 島田 能史, 中野 雅人, 中野 麻恵, 木戸 知紀, 田島 陽介, 岩城 孝和, 八木 寛, 細井 愛, 八木 亮磨, 田村 博史, 堀田 真之介, 橋本 喜文, 小柳 英人, 水木 亨, 山本 潤, 阿部 馨, 山田 沙希, 若井 俊文

    日本外科学会定期学術集会抄録集117回   SF - 2   2017.4

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  • Clinical significance of NQO1 expression in KRAS wild-type colorectal cancer Reviewed

    Hitoshi Kameyama, Yuki Hirose, Yasunobu Matsuda, Masayuki Nagahashi, Hiroshi Ichikawa, You Sato, Saki Yamada, Shinnosuke Hotta, Yosuke Tajima, Takuma Okamura, Mae Nakano, Masato Nakano, Yoshifumi Shimada, Jun Sakata, Takashi Kobayashi, Toshifumi Wakai

    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY10 ( 5 ) 5841 - 5849   2017

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:E-CENTURY PUBLISHING CORP  

    NAD(P)H: quinone oxidoreductase-1 (NQO1) protects cells against redox cycling and oxidative stress; however, in cancer cells, NQO1 confers resistance against anticancer agents. The aim of this study was to evaluate the association between NQO1 expression and prognosis in patients with advanced (locally advanced or metastatic/recurrent) colorectal cancer (CRC). A retrospective analysis of 47 patients [28 male and 19 female; median age: 62 years (range, 17-78)] with advanced CRC was conducted. Immunohistochemical examination of tumor tissue specimens was performed using monoclonal anti-NQO1 antibody. The association of NQO1 expression with patient characteristics, chemotherapeutic response, and clinical prognosis was assessed. Therapeutic efficacy (complete response, partial response, stable disease, and progressive disease) was evaluated using Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. We compared the therapeutic efficacy in KRAS wild and mutant CRC because epidermal growth factor receptor (EGFR)-signaling pathway plays a pivotal role in CRC. Of the 47 patients, 31 (66.0%) had KRAS wild CRC and 16 (34.0%) had KRAS mutant CRC. Moreover, 37 (78.7%) had NQO1-positive tumors and 10 (21.3%) had NQO1-negative tumors. Among the patients with KRAS wild CRC, NQO1-negative patients showed significantly better disease control rate (complete response + partial response + stable disease) than NQO1-positive patients (P = 0.028). Moreover, NQO1-negative patients had longer progression-free survival and overall survival than NQO1-positive patients (P = 0.041 and P = 0.043, respectively). NQO1 expression in the tumor may be a predictor of therapeutic efficacy and prognosis in patients with KRAS wild advanced CRC.

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  • An adenocarcinoma arising in the ileal pouch after total proctocolectomy with ileal pouch-anal anastomosis for familial adenomatous polyposis Reviewed

    Yoshifumi Hashimoto, Masato Nakano, Hitoshi Kameyama, Saki Yamada, Ryoma Yagi, Yosuke Tajima, Takuma Okamura, Mae Nakano, Yoshifumi Shimada, Toshifumi Wakai

    Japanese Journal of Gastroenterological Surgery50 ( 6 ) 469 - 475   2017

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society of Gastroenterological Surgery  

    We report the case of a 45-year-old man, who at the age of 24 had total proctocolectomy with ileal W-pouch anal anastomosis for familial adenomatous polyposis. A follow-up transanal endoscopy performed at the age of 38 revealed approximately 30 polyps in the ileal pouch, which were then confirmed by biopsy to be tubular adenomas. A transanal endoscopy performed at the age of 44 revealed an 8 mm 0-Is lesion located approximately 1 cm proximal to the ileal pouch-anal anastomosis, which was then removed by EMR. Histopathological analysis showed the presence of well-differentiated tubular adenocarcinoma in adenoma. To date, no recurrence of adenocarcinoma has been confirmed in follow-up transanal endoscopies. We have experienced treating a case of adenocarcinoma arising in the ileal pouch through the adenoma-carcinoma sequence after total proctocolectomy with ileal pouch-anal anastomosis for familial adenomatous polyposis. For early diagnosis and prompt treatment, it is important to perform periodic surveillance of the ileal pouch and conduct aggressive endoscopic resection when a large adenoma exceeding 10 mm is found.

    DOI: 10.5833/jjgs.2016.0055

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  • Clinical significance of perineural invasion diagnosed by immunohistochemistry with anti-S100 antibody in Stage I-III colorectal cancer Reviewed

    Yoshifumi Shimada, Tomoki Kido, Hitoshi Kameyama, Mae Nakano, Ryoma Yagi, Yosuke Tajima, Takuma Okamura, Masato Nakano, Masayuki Nagahashi, Takashi Kobayashi, Masahiro Minagawa, Shin-ichi Kosugi, Toshifumi Wakai, Yoichi Ajioka

    SURGERY TODAY45 ( 12 ) 1493 - 1500   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER  

    Perineural invasion (PN) diagnosed by hematoxylin-eosin (HE) staining is an important prognostic factor after curative-intent surgery in patients with colorectal cancer. However, the clinical significance of PN diagnosed by immunohistochemistry (IHC) has not been investigated. The present study assessed the clinical significance of PN diagnosed by IHC with an anti-S100 antibody in patients with colorectal cancer.
    We retrospectively enrolled 184 consecutive patients with stage I-III colorectal cancer who had undergone curative-intent surgery. We analyzed the absence/presence of PN diagnosed by HE staining (HE-PN) compared to that diagnosed by IHC with the anti-S100 antibody (S100-PN). Potential prognostic factors were identified by univariate and multivariate analyses of the overall and relapse-free survival. The statistics were used to assess the inter-observer reproducibility.
    The incidence of HE-PN and S100-PN among the 184 patients was 60 patients (32.6 %) and 113 patients (61.4 %), respectively (P < 0.001). A multivariate Cox proportional hazards regression model analysis indicated that S100-PN was an independent prognostic factor for both the overall and relapse-free survival. The value was 0.77 for S100-PN and 0.47 for HE-PN.
    PN diagnosed by IHC is an important prognostic factor in patients with colorectal cancer. An inter-observer assessment showed superior judgment reproducibility for S100-PN compared with HE-PN.

    DOI: 10.1007/s00595-014-1096-9

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  • Mesorectal Lymph Node Metastasis Arising from Rectal Invasion by an Ovarian Cancer--A Case Report Reviewed

    Toru Mizuki, Yoshifumi Shimada, Yutaka Yagi, Yosuke Tajima, Mae Nakano, Masato Nakano, Kumiko Tatsuda, Takashi Ishikawa, Jun Sakata, Hitoshi Kameyama, Takashi Kobayashi, Shin ichi Kosugi, Yu Koyama, Toshifumi Wakai, Takayuki Enomoto

    Gan to kagaku ryoho. Cancer & chemotherapy42   2300 - 2302   2015.11

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    A 58-year-old woman presenting with abdominal distension was diagnosed with a tumor in the right ovary. A chest-abdominal-pelvic computed tomography scan revealed multiple lung metastases, multiple liver metastases, and peritoneal dissemination. Invasion of the rectum by peritoneal dissemination of the Douglas' pouch was suspected. She was diagnosed with Stage Ⅳ right ovarian cancer and was treated with preoperative chemotherapy. After chemotherapy, debulking surgery of the abdominal cavity (total hysterectomy, bilateral salpingo-oophorectomy, partial omentectomy, and Hartmann's procedure) was performed. Because there was swelling observed in multiple mesorectal lymph nodes, lymph node dissection was performed based on methods used for rectal cancer surgery. Postoperative histopathological examination revealed multiple mesorectal lymph node metastases arising from ovarian cancer. We suggest that mesorectal lymph node dissection be considered a part of debulking surgery for ovarian cancers that have invaded the rectum.

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  • [A Case of Long-Term Survival Following Metastasectomies of Liver Metastasis, Lung Metastasis, and Peritoneal Dissemination of Cecal Cancer]. Reviewed

    Yamamoto J, Nakano M, Shimada Y, Kameyama H, Yamada S, Yagi R, Tatsuda K, Tajima Y, Okamura T, Nakano M, Nagahashi M, Sakata J, Kobayashi T, Kosugi S, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy42 ( 12 ) 1597 - 1599   2015.11

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  • [Three Cases of Stage Ⅳ Low Rectal Cancer with Lateral Pelvic Lymph Node Metastasis]. Reviewed

    Tamura H, Shimada Y, Yagi R, Tajima Y, Okamura T, Nakano M, Ishikawa T, Sakata J, Kobayashi T, Kameyama H, Kosugi S, Wakai T, Nogami H, Maruyama S, Takii Y

    Gan to kagaku ryoho. Cancer & chemotherapy42 ( 12 ) 2303 - 2305   2015.11

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  • A case of early gastric cancer completely responding to adjuvant chemotherapy for advanced colon cancer Reviewed

    Ryo Tanaka, Hitoshi Kameyama, Mae Nakano, Hiroshi Ichikawa, Takaaki Hanyu, Masato Nakano, Takashi Ishikawa, Yoshifumi Shimada, Jun Sakata, Takashi Kobayashi, Shin-Ichi Kosugi, Masahiro Minagawa, Yu Koyama, Toshifumi Wakai

    Japanese Journal of Cancer and Chemotherapy41 ( 12 ) 2364 - 2366   2014.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Journal of Cancer and Chemotherapy Publishers Inc.  

    A 70-year-old man was referred to our hospital with ascending colon cancer (cT3N1M0, Stage IIIa), which was found during examinations following a positive fecal occult blood test. The patient was also diagnosed with early gastric cancer (cT1a, NO, MO, Stage IA) during a preoperative gastroscopy examination. A laparoscopically assisted right colectomy and D3 lymphadenectomy was performed for the ascending colon cancer. The postoperative pathological diagnosis was Stage IIIb (pT3N2), he was administered in combination with capecitabine plus oxaliplatin (CapeOX) as adjuvant chemotherapy before the treatment for the colon cancer. After 6 months of adjuvant chemotherapy, we were unable to detect any gastric lesions at the same location using gastroscopy, and so diagnosed a clinical complete response. A follow-up gastroscopy 6 months later showed the same findings. The patient has had no recurrence of gastric cancer for 18 months after the initial operation. He will continue to be followed up closely using gastroscopy. In this case, CapeOX as adjuvant chemotherapy for advanced colon cancer was also effective for early gastric cancer.

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  • A case of an elderly patient who underwent single-incision laparoscopic surgery for small intestine cancer Reviewed

    Yoshifumi Hashimoto, Hitoshi Kameyama, Yuki Hirose, Ryoma Yagi, Mae Nakano, You Sato, Tomoki Kido, Hiroshi Ichikawa, Takaaki Hanyu, Masato Nakano, Takashi Ishikawa, Yoshifumi Shimada, Takashi Kobayashi, Jun Sakata, Masahiro Minagawa, Shin-Ichi Kosugi, Yu Koyama, Toshifumi Wakai

    Japanese Journal of Cancer and Chemotherapy41 ( 12 ) 2442 - 2443   2014.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Journal of Cancer and Chemotherapy Publishers Inc.  

    An 81-year-old man presented with chief complaints of abdominal pain and vomiting. Intestinal obstruction was found at the time of admission to a local hospital in October 2011. Conservative treatment provided symptomatic relief
    however, he was readmitted with similar symptoms in December 2011. Small-intestinal wall thickening was detected by abdominal and pelvic computed tomography, and he was referred to our hospital. Small-bowel endoscopy revealed an elevated subcircumferential tumor in the jejunum. Biopsy revealed well to moderately differentiated adenocarcinoma diagnosed as jejunal cancer, which caused narrowing of the jejunum. Single-incision laparoscopy-assisted small-bowel resection was performed. The intraoperative findings were a tumor with inflammatory changes in the jejunum and enlarged surrounding lymph nodes. We performed regional lymph node dissection. Histopathological analysis showed moderately differentiated small-intestinal tubular adenocarcinoma and 2 of 5 lymph nodes positive for metastatic cancer cells. After an uneventful postoperative course, he was discharged on day 7. He preferred not to undergo postoperative adjuvant chemotherapy and quickly recovered his activities of daily living postoperatively. He stayed home until he developed abdominal distention resulting from peritoneal recurrence 1 year and 6 months postoperatively and died 1 month later.

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  • A case of descending colon cancer with multiple liver metastases effectively treated with capecitabine/oxaliplatin (CapeOX) and bevacizumab Reviewed

    Mae Nakano, Hitoshi Kameyama, Yoshifumi Shimada, Yoshifumi Hashimoto, Mana Hosoi, Masato Nakano, Hitoshi Nogami, Takaaki Hanyu, Kazuyasu Takizawa, Takashi Ishikawa, Jun Sakata, Takashi Kobayashi, Masahiro Minagawa, Shin-Ichi Kosugi, Yu Koyama, Toshifumi Wakai

    Japanese Journal of Cancer and Chemotherapy41 ( 12 ) 1785 - 1787   2014.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Journal of Cancer and Chemotherapy Publishers Inc.  

    A 57-year-old woman was referred to our hospital because of descending colon cancer with multiple liver metastases. Abdominal magnetic resonance imaging (MRI) revealed 13 liver metastases across the lobes. We started combination chemotherapy with capecitabine/oxaliplatin (CapeOX) and bevacizumab. After 9 courses of the treatment, the number and size of the liver metastases were remarkably reduced on MRI. Left colectomy and partial hepatectomy were performed. Histopathological examination revealed no residual cancer cells in the colon but revealed a few cancer cells in 4 of 7 resected liver specimens. At 11 postoperative months, 1 liver metastasis reappeared, for which we performed laparoscopy-assisted partial hepatectomy. At 21 months after the second operation, the patient was well without any signs of recurrence. Thus, the combination chemotherapy with CapeOX and bevacizumab allowed for the successful resection of the tumor and metastasis in our patient who initially had unresectable colon cancer and multiple liver metastases.

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  • Single-port laparoscopic stoma creation for fecal diversion - Experience of ten consecutive patients Reviewed

    Ryoma Yagi, Hitoshi Kameyama, Mae Nakano, You Sato, Tomoki Kido, Masato Nakano, Yoshifumi Shimada, Jun Sakata, Takashi Kobayashi, Masahiro Minagawa, Shin-Ichi Kosugi, Yu Koyama, Toshifumi Wakai

    Japanese Journal of Cancer and Chemotherapy41 ( 12 ) 1643 - 1644   2014.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Journal of Cancer and Chemotherapy Publishers Inc.  

    Purpose: In the present study, we aimed to describe the surgical results of single-port laparoscopic stoma creation in our institution. Methods: We examined the safety of the surgical procedure and short-term results in 10 consecutive patients who underwent single-port laparoscopic stoma creation at our hospital between April 2011 and July 2013. Results: The median age of the patients was 60.5 (range, 31-75) years. Five patients were men, and 5 were women. There were 5 cases of colorectal cancer, 2 each of extramammary Paget's disease and uterine cancer, and one of perineal neurofibroma. Eight surgeries were performed for bowel obstruction or stenosis, and two surgeries were performed for other reasons. The median operative time was 59.5 (range, 40-91) min, blood loss volume was 0 (range, 0-10) mL, postoperative duration before commencement of oral intake was 2.5 (range, 1-4) days, and duration of postoperative hospital stay was 11 (range, 5-19) days. No short-term complications were noted after the surgery. Conclusion: Single-port laparoscopic stoma creation appears to be feasible in terms of safety and short-term surgical results, and may improve the quality of life of patients requiring fecal diversion.

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  • A case of long-term survival in a patient with rectal cancer with virchow lymph node metastasis, liver metastases, and lung metastases Reviewed

    Hidehito Oyanagi, Hitoshi Kameyama, Hitoshi Nogami, Yoshifumi Shimada, Mae Nakano, Masato Nakano, Takashi Ishikawa, Jun Sakata, Takashi Kobayashi, Masahiro Minagawa, Shin-Ichi Kosugi, Yu Koyama, Toshifumi Wakai

    Japanese Journal of Cancer and Chemotherapy41 ( 12 ) 1674 - 1676   2014.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Journal of Cancer and Chemotherapy Publishers Inc.  

    A 69-year-old man with advanced rectal cancer and liver metastases was treated with 2 courses of chemotherapy with irinotecan and S-1 followed by low anterior resection and partial hepatectomy. Chemotherapy with S-1 was then administered for 22 months. However, lung metastases developed, for which partial pneumonectomy was performed. Seven months later, computed tomography (CT) revealed swelling of the left supraclavicular lymph node. Despite chemotherapy with 5-fluorouracil, Leucovorin, and oxaliplatin (mFOLFOX6)
    5-fluorouracil, Leucovorin and irinotecan (FOLFIRI)
    and capecitabine plus bevacizumab, the lung metastases recurred and Virchow lymph node swelling was noted again. Accordingly, palliative therapy was administered. The patient died 3 years 1 month after Virchow lymph node resection. Herein, we describe a case of advanced rectal cancer, in which lung and Virchow lymph node metastases developed after liver metastasis. Surgical excision of the metastases resulted in long-term survival of 6 years following the first operation.

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  • Surgical curative resection after chemotherapy and portal vein embolization for multiple liver metastases of rectal cancer - Report of a case Reviewed

    Shinnosuke Hotta, Hitoshi Nogami, Mae Nakano, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Jun Sakata, Takashi Kobayashi, Masahiro Minagawa, Shin-ichi Kosugi, Yu Koyama, Toshifumi Wakai

    Japanese Journal of Cancer and Chemotherapy41 ( 12 ) 1794 - 1795   2014.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Journal of Cancer and Chemotherapy Publishers Inc.  

    A 34-year-old woman presenting with bloody stools was diagnosed with a rectal tumor. Computed tomography (CT) revealed multiple liver masses in Couinaud segments IV, V, and VU. The lesions were diagnosed as multiple liver metastases from rectal cancer. Right trisegmentectomy of the liver was considered the optimal treatment option for curative resection
    however, liver volumetric examination using CT estimated that the remnant liver volume after right trisegmentectomy would be only 24.6 % of the total liver volume. Therefore, she underwent resection of the primary lesion followed by systemic chemotherapy for multiple liver metastases. She showed a partial response, according to the Response Evaluation Criteria in Solid Tumors, after 5 courses of capecitabine/oxaliplatin plus bevacizumab. Embolization of the right branch of the portal vein was performed to increase liver volume. A subsequent liver volumetric examination with CT estimated that the remnant liver volume after right trisegmentectomy would be 38.4 % of the total liver volume. Therefore, she underwent right trisegmentectomy of the liver for curative resection of the liver metastases. She had had no signs of recurrence at 3 years and 6 months after initial surgery.

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  • A case of curatively resected, locally advanced ascending colon cancer with ileal conduit invasion Reviewed

    Hitoshi Kameyama, Yoshifumi Shimada, Hitoshi Nogami, Mae Nakano, Masato Nakano, Jun Sakata, Takashi Kobayashi, Masahiro Minagawa, Shin-Ichi Kosugi, Yu Koyama, Toshifumi Wakai

    Japanese Journal of Cancer and Chemotherapy41 ( 12 ) 1677 - 1679   2014.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Journal of Cancer and Chemotherapy Publishers Inc.  

    A 71-year-old man was referred to our hospital because of repeated bowel obstruction. He had previously undergone cystectomy with ileal conduit urinary diversion for the treatment of bladder cancer at the age of 28 years. Computed tomography revealed a mass in the ascending colon. Ileostomy was initially performed because of poor general condition that improved with postoperative nutrition management. Enema findings revealed ascending colon cancer and we therefore decided to perform curative surgery. Intraoperative findings revealed that the ascending colon cancer had invaded the ileal conduit. However, it was confirmed that the ureter-ileal conduit anastomosis and the mesentery of the ileal conduit could be preserved. We performed right colectomy and partial resection of the ileal conduit with curative intent. The pathological stage was pT4bpN0cM0, pStage II. There were no signs of recurrence 15 months after curative surgery.

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MISC

  • 【炎症性腸疾患アップデート-いま外科医に求められる知識と技術】周術期管理 炎症性腸疾患の周術期管理

    亀山 仁史, 田島 陽介, 島田 能史, 山田 沙季, 阿部 馨, 田中 花菜, 小柳 英人, 中野 麻恵, 中野 雅人, 若井 俊文

    臨床外科73 ( 12 ) 1394 - 1398   2018.11

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    Language:Japanese   Publisher:(株)医学書院  

    <文献概要>ポイント ◆内科,外科が緊密な連携をとり,ステロイド・免疫調節薬・生物学的製剤などの薬剤管理を行う.◆炎症性腸疾患に特徴的な,日和見感染,血栓症などの合併症も考慮に入れた適切な周術期管理が重要である.◆分割手術,ストーマ管理,合併症について,適切な対応と十分なインフォームド・コンセントが必要である.

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  • 当科における出産後女性医師の働き方について

    中野 麻恵

    ENDOSCOPIC FORUM for digestive disease34 ( 1 ) 68 - 68   2018.6

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  • CapeOX+Bevacizumab療法が著効した下行結腸癌多発肝転移の1例

    中野 麻恵, 亀山 仁史, 島田 能史, 橋本 喜文, 細井 愛, 中野 雅人, 野上 仁, 羽入 隆晃, 滝沢 一泰, 石川 卓, 坂田 純, 小林 隆, 皆川 昌広, 小杉 伸一, 小山 諭, 若井 俊文

    癌と化学療法41 ( 12 ) 1785 - 1787   2014.11

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    症例は57歳、女性。検診便潜血陽性の精査で、多発肝転移を伴う下行結腸癌(1/4周、低分化腺癌)と診断された。肝転移はMRI検査で両葉に13個認め、術前化学療法の方針となった。capecitabine/oxaliplatin(CapeOX)+bevacizumab(BV)療法を9コース施行したところ、原発巣は瘢痕化、肝転移は5個と減少し、partial response(PR)と判定し、左結腸切除術、肝部分切除術を施行した。術中超音波検査では肝臓に7病変を認め、すべて部分切除が可能でR0の手術となった。病理診断では原発巣は癌細胞を認めず、肝転移は切除した7病変のうち4病変にわずかに癌細胞の残存を認めるのみであった。術後11ヵ月目に肝S5に単発の肝転移を認め、腹腔鏡補助下肝部分切除術を施行した。現在、21ヵ月無再発生存中である。CapeOX+BV療法は切除不能肝転移大腸癌に対して、根治切除を可能とする有用な治療法と考えられた。(著者抄録)

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  • 回腸人工肛門閉鎖後にBacterial translocationによるものと考えられる敗血症をきたした1例

    伏木 麻恵, 下山 雅朗, 遠藤 和彦

    日本大腸肛門病学会雑誌67 ( 3 ) 168 - 172   2014.3

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    人工肛門閉鎖術は比較的低侵襲の手術ではあるが,術後にBacterial translocationによるものと考えられる敗血症の1例を経験したので報告する.症例は61歳,男性.3ヵ月前に直腸癌に対して超低位前方切除術,一時的回腸人工肛門造設術を施行し,今回人工肛門閉鎖を行った.第2病日に食事を開始したところ,悪寒・戦慄および発熱が出現し,第6病日に敗血症性ショックをきたした.種々の検査にて明らかな感染源は特定されなかったため,Bacterial translocationをきたし,敗血症に至ったと考えられた.人工肛門閉鎖術後は廃用性萎縮している人工肛門の肛門側腸管に食物が通過した際にBacterial translocationをきたす可能性があるため,注意が必要であると考えられた.(著者抄録)

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  • 潰瘍性大腸炎に合併する大腸腫瘍におけるサーベイランス内視鏡検査の臨床的意義

    伏木 麻恵

    新潟医学会雑誌128 ( 2 ) 75 - 82   2014.2

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    【緒言】近年、本邦における潰瘍性大腸炎の患者数は増加傾向である。それに伴い潰瘍性大腸炎の長期経過例も増加し、潰瘍性大腸炎の慢性炎症粘膜を発生母地とする大腸癌、およびその前癌病変と考えられるdysplasiaが増加している。そのため、これらの病変を発見するためのサーベイランスプログラムを確立することが重要と考えられている。しかし、過去の研究では、潰瘍性大腸炎患者に対してサーベイランスを行うこと自体の臨床的意義については十分に検討されてこなかった。本研究の目的は、サーベイランスが潰瘍性大腸炎に合併する大腸腫瘍を早期に発見することおよび予後改善に寄与するかを明らかにすることである。【方法】1991年1月から2012年12月の間に新潟大学医歯学総合病院で手術を施行され、術後の病理診断で潰瘍性大腸炎に合併した大腸癌もしくはdysplasiaと診断された18例を対象とした。本研究では、潰瘍性大腸炎に合併する大腸腫瘍を発見するためのサーベイランスを、"潰瘍性大腸炎の診断から7年以上経過した全大腸炎型もしくは左側大腸炎型症例に対して、大腸癌のスクリーニングを意図して施行した内視鏡検査"と定義した。そして、サーベイランスの生検で組織学的に癌あるいはdysplasiaが証明され、手術が施行された症例をサーベイランス群とし、サーベイランス群と非サーベイランス群における臨床病理学的特徴および術後成績を統計学的に比較検討した。【結果】対象18例中、サーベイランス群は13例(72%)、非サーベイランス群は5例(28%)であった。サーベイランス群は非サーベイランス群と比較して、リンパ節転移の頻度が有意に低く(8% vs 60%;P=0.044)、Stage0、Iの頻度が有意に高かった(85% vs 20%;P=0.022)。また、サーベイランス群は13例全例が生存しているのに対し、非サーベイランス群では5例中2例が大腸癌死していた。術後の累積5年生存率は、サーベイランス群が100%、非サーベイランス群が50%であった(P=0.018)。【結論】サーベイランスを行うことにより、潰瘍性大腸炎に合併する大腸腫瘍が早期に発見され、潰瘍性大腸炎患者の予後が改善する。(著者抄録)

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