Updated on 2024/04/24

写真a

 
SUZUKI Toshio
 
Organization
Academic Assembly Institute of Science and Technology SEISAN DESIGN KOUGAKU KEIRETU Professor
Graduate School of Science and Technology Advanced Materials Science and Technology Professor
Faculty of Engineering Department of Engineering Professor
Title
Professor
External link

Degree

  • 理学博士 ( 1989.3   東北大学 )

Research Interests

  • Physiological activity

  • Natural products

  • Stereoselective synthesis

Research Areas

  • Nanotechnology/Materials / Synthetic organic chemistry

  • Nanotechnology/Materials / Bio chemistry

Research History (researchmap)

  • Niigata University

    1995 - 2000

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  • Niigata University, Associate Professor

    1995 - 2000

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  • Niigata University

    1992 - 1995

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  • Niigata University, Research Assistant

    1992 - 1995

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  • Tohoku University

    1989 - 1992

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  • Tohoku University, Research Assistant

    1989 - 1992

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Research History

  • Niigata University   Faculty of Engineering Department of Engineering   Professor

    2017.4

  • Niigata University   Graduate School of Science and Technology Advanced Materials Science and Technology   Professor

    2004.4

  • Niigata University   Graduate School of Science and Technology Advanced Materials Science and Technology   Professor

    2004.4

  • Niigata University   Faculty of Engineering Department of Chemistry and Chemical Engineering   Professor

    2000.6 - 2017.3

  • Niigata University   Graduate School of Science and Technology   Associate Professor (as old post name)

    1996.4 - 2000.5

  • Niigata University   Faculty of Engineering   Associate Professor (as old post name)

    1995.4 - 1996.3

  • Niigata University   Graduate School of Science and Technology   Research Assistant

    1992.3 - 1995.3

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Education

  • Tohoku University   理学研究科   化学専攻

    - 1989

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    Country: Japan

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  • Tohoku University   Graduate School, Division of Natural Science

    - 1989

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  • Tohoku University   Faculty of Science

    - 1984

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  • Tohoku University   Faculty of Science   化学第二学科

    - 1984

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    Country: Japan

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Professional Memberships

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MISC

  • Total synthesis of (+)-laurallene

    T Saitoh, T Suzuki, M Sugimoto, H Hagiwara, T Hoshi

    TETRAHEDRON LETTERS   44 ( 15 )   3175 - 3178   2003.4

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    Language:English   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    The stereoselective total synthesis of (+)-laurallene is described. The required key oxocene skeleton possessing trans-orientated alkyl substituents at the alpha,alpha'-positions was stereo selectively constructed via the cyclization of the corresponding hydroxy epoxide promoted by Eu(fod)(3). (C) 2003 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0040-4039(03)00432-5

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  • First synthesis of 1,9-dideoxyforskolin from ptychantin A

    Hisahiro Hagiwara, Fumihide Takeuchi, Takashi Hoshi, Toshio Suzuki, Toshihiro Hashimoto, Yoshinori Asakawa

    Tetrahedron Letters   44 ( 11 )   2305 - 2306   2003.3

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    Language:English   Publisher:Elsevier Ltd  

    1,9-Dideoxyforskolin 2 has been synthesized starting from ptychantin A 3. © 2003 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0040-4039(03)00236-3

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  • First synthesis of 1,9-dideoxyforskolin from ptychantin A

    H Hagiwara, F Takeuchi, T Hoshi, T Suzuki, T Hashimoto, Y Asakawa

    TETRAHEDRON LETTERS   44 ( 11 )   2305 - 2306   2003.3

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    Language:English   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    1,9-Dideoxyforskolin 2 has been synthesized starting from ptyebantin A 3. (C) 2003 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0040-4039(03)00236-3

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  • Stereospecific synthesis of eight- and nine-membered cyclic ethers by Eu(fod)(3)-mediated cyclization of hydroxy epoxides

    T Saitoh, T Suzuki, N Onodera, H Sekiguchi, H Hagiwara, T Hoshi

    TETRAHEDRON LETTERS   44 ( 13 )   2709 - 2712   2003.3

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    Language:English   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    An efficient and versatile method for the stereospecific construction of alpha,omega-cis- and alpha,omega-trans-disubstituted eight- and nine-membered cyclic ethers was developed. Cyclization of the hydroxy epoxides promoted by Eu(fod)(3) proceeded via an S(N)2 process and exo mode to provide the corresponding cyclic ethers in excellent yields. (C) 2003 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0040-4039(03)00335-6

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  • Stereospecific synthesis of eight- and nine-membered cyclic ethers by Eu(fod)(3)-mediated cyclization of hydroxy epoxides

    T Saitoh, T Suzuki, N Onodera, H Sekiguchi, H Hagiwara, T Hoshi

    TETRAHEDRON LETTERS   44 ( 13 )   2709 - 2712   2003.3

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    Language:English   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    An efficient and versatile method for the stereospecific construction of alpha,omega-cis- and alpha,omega-trans-disubstituted eight- and nine-membered cyclic ethers was developed. Cyclization of the hydroxy epoxides promoted by Eu(fod)(3) proceeded via an S(N)2 process and exo mode to provide the corresponding cyclic ethers in excellent yields. (C) 2003 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0040-4039(03)00335-6

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  • First total synthesis of valeriananoid A

    Hisahiro Hagiwara, Akihiro Morii, Yu Yamada, Takashi Hoshi, Toshio Suzuki

    Tetrahedron Letters   44 ( 8 )   1595 - 1597   2003.2

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    A tricyclic sesquiterpenoid, valeriananoid A 1, has been synthesized via domino Michael reaction of oxophorone 4 and subsequent 6-endo-trig cyclization of a ketyl radical as key steps. © 2003 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0040-4039(03)00064-9

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  • First Total Synthesis of Valeriananoid A(共著)

    HAGIWARA H, MORII A, YAMADA Y, HOSHI T, SUZUKI T

    Tetrahedron Lett.   44 ( 8 )   1595 - 1597   2003

  • Total Synthesis of (+)-Laurallene(共著)

    Tetrahedron Lett.   44 ( 16 )   3175-3178.   2003

  • First total syntheses of the phytotoxins solanapyrones D and E via the domino Michael protocol

    H Hagiwara, K Kobayashi, S Miya, T Hoshi, T Suzuki, M Ando, T Okamoto, M Kobayashi, Yamamoto, I, S Ohtsubo, M Kato, H Uda

    JOURNAL OF ORGANIC CHEMISTRY   67 ( 17 )   5969 - 5976   2002.8

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    Language:English   Publisher:AMER CHEMICAL SOC  

    The phytotoxins solanapyrones D (1) and E (2) have been synthesized from the decalone prepared by the domino Michael reaction of the kinetic enolate of optically pure acetylcyclohexene with methyl crotonate. The decalone was transformed into a solanapyrone core by equilibration into thermodynamically stable trans-decalone (11), dehydroxylation, and dehydration. Condensation of a methyl acetoacetate equivalent followed by cyclization installed a pyrone moiety. Introduction of a formyl or hydroxymethyl unit into the pyrone ring via Pummerer related reactions furnished solanapyrones D (1) and E (2).

    DOI: 10.1021/jo0163602

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  • First total syntheses of the phytotoxins solanapyrones D and E via the domino Michael protocol

    H Hagiwara, K Kobayashi, S Miya, T Hoshi, T Suzuki, M Ando, T Okamoto, M Kobayashi, Yamamoto, I, S Ohtsubo, M Kato, H Uda

    JOURNAL OF ORGANIC CHEMISTRY   67 ( 17 )   5969 - 5976   2002.8

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    Language:English   Publisher:AMER CHEMICAL SOC  

    The phytotoxins solanapyrones D (1) and E (2) have been synthesized from the decalone prepared by the domino Michael reaction of the kinetic enolate of optically pure acetylcyclohexene with methyl crotonate. The decalone was transformed into a solanapyrone core by equilibration into thermodynamically stable trans-decalone (11), dehydroxylation, and dehydration. Condensation of a methyl acetoacetate equivalent followed by cyclization installed a pyrone moiety. Introduction of a formyl or hydroxymethyl unit into the pyrone ring via Pummerer related reactions furnished solanapyrones D (1) and E (2).

    DOI: 10.1021/jo0163602

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  • Total synthesis of bisabolane sesquiterpenoids, alpha-bisabol-1-one, curcumene, curcuphenol and elvirol: utility of catalytic enamine reaction in cyclohexenone synthesis

    H Hagiwara, T Okabe, H Ono, VP Kamat, T Hoshi, T Suzuki, M Ando

    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1   ( 7 )   895 - 900   2002

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    Language:English   Publisher:ROYAL SOC CHEMISTRY  

    Total syntheses of alpha-bisabol-1-one, curcumene, curcuphenol and elvirol have been accomplished via 1,4-conjugate addition of intact aldehydes to vinyl ketones followed by an intramolecular aldol condensation.

    DOI: 10.1039/b200629b

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  • Conjugate addition of unmodified aldehydes: recycle of heterogeneous amine catalyst and ionic liquid

    H Hagiwara, T Sayuri, T Okabe, T Hoshi, T Suzuki, H Suzuki, K Shimizu, Y Kitayama

    GREEN CHEMISTRY   4 ( 5 )   461 - 463   2002

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    Language:English   Publisher:ROYAL SOC CHEMISTRY  

    Unmodified aldehydes add to vinylketones in 1,4-manner in ionic liquid, [bmim]PF(6), in the presence of a catalytic amount of propylamine grafted on silica. The ionic liquid involving the catalyst has been recycled intact without loss of efficiency.

    DOI: 10.1039/b201900k

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  • Conjugate addition of unmodified aldehydes: recycle of heterogeneous amine catalyst and ionic liquid

    H Hagiwara, T Sayuri, T Okabe, T Hoshi, T Suzuki, H Suzuki, K Shimizu, Y Kitayama

    GREEN CHEMISTRY   4 ( 5 )   461 - 463   2002

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    Language:English   Publisher:ROYAL SOC CHEMISTRY  

    Unmodified aldehydes add to vinylketones in 1,4-manner in ionic liquid, [bmim]PF(6), in the presence of a catalytic amount of propylamine grafted on silica. The ionic liquid involving the catalyst has been recycled intact without loss of efficiency.

    DOI: 10.1039/b201900k

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  • The first enantioselective total synthesis of cyclomyltaylane-5 alpha-ol and determination of its absolute stereochemistry

    H Hagiwara, H Sakai, T Uchiyama, Y Ito, N Morita, T Hoshi, T Suzuki, M Ando

    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1   ( 5 )   583 - 591   2002

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    Language:English   Publisher:ROYAL SOC CHEMISTRY  

    The tetracyclic sesquiterpenoid (+)-cyclomyltaylan-5alpha-ol 1 has been synthesized starting from (S)-(+)-Hajos-Wiechert ketone analogue 10 via stereoselective Claisen rearrangement followed by SmI2-promoted reductive cyclisation. Thus, the absolute configuration has been established to be 2R, 3R, 4R, 5S, 6R, 7R (cyclomyltaylane numbering) as depicted in structure 1.

    DOI: 10.1039/b111594b

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  • The first enantioselective total synthesis of cyclomyltaylane-5 alpha-ol and determination of its absolute stereochemistry

    H Hagiwara, H Sakai, T Uchiyama, Y Ito, N Morita, T Hoshi, T Suzuki, M Ando

    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1   ( 5 )   583 - 591   2002

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    Language:English   Publisher:ROYAL SOC CHEMISTRY  

    The tetracyclic sesquiterpenoid (+)-cyclomyltaylan-5alpha-ol 1 has been synthesized starting from (S)-(+)-Hajos-Wiechert ketone analogue 10 via stereoselective Claisen rearrangement followed by SmI2-promoted reductive cyclisation. Thus, the absolute configuration has been established to be 2R, 3R, 4R, 5S, 6R, 7R (cyclomyltaylane numbering) as depicted in structure 1.

    DOI: 10.1039/b111594b

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  • Total synthesis of bisabolane sesquiterpenoids, alpha-bisabol-1-one, curcumene, curcuphenol and elvirol: utility of catalytic enamine reaction in cyclohexenone synthesis

    H Hagiwara, T Okabe, H Ono, VP Kamat, T Hoshi, T Suzuki, M Ando

    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1   ( 7 )   895 - 900   2002

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    Language:English   Publisher:ROYAL SOC CHEMISTRY  

    Total syntheses of alpha-bisabol-1-one, curcumene, curcuphenol and elvirol have been accomplished via 1,4-conjugate addition of intact aldehydes to vinyl ketones followed by an intramolecular aldol condensation.

    DOI: 10.1039/b200629b

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  • The first total synthesis of (+)-rogioloxepane A

    Ryuji Matsumura, Toshio Suzuki, Hisahiro Hagiwara, Takashi Hoshi, Masayoshi Ando

    Tetrahedron Letters   42 ( 8 )   1543 - 1546   2001.2

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    The first total synthesis of (+)-rogioloxepane A is described. The α,ω-trans-disubstituted oxepene skeleton was stereoselectively constructed via cyclization of the hydroxy epoxide promoted by the (Bu3Sn)2O/Zn(OTf)2 system. The proposed configurations of 6R and 13R were confirmed through this synthetic study. © 2001 Elsevier Science Ltd.

    DOI: 10.1016/S0040-4039(00)02281-4

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  • The first total synthesis of (+)-rogioloxepane A

    Ryuji Matsumura, Toshio Suzuki, Hisahiro Hagiwara, Takashi Hoshi, Masayoshi Ando

    Tetrahedron Letters   42 ( 8 )   1543 - 1546   2001.2

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    Language:English  

    The first total synthesis of (+)-rogioloxepane A is described. The α,ω-trans-disubstituted oxepene skeleton was stereoselectively constructed via cyclization of the hydroxy epoxide promoted by the (Bu3Sn)2O/Zn(OTf)2 system. The proposed configurations of 6R and 13R were confirmed through this synthetic study. © 2001 Elsevier Science Ltd.

    DOI: 10.1016/S0040-4039(00)02281-4

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  • Formal synthesis of (+)-isolaurepinnacin

    Toshio Suzuki, Ryuji Matsumura, Ken-ichi Oku, Keiichi Taguchi, Hisahiro Hagiwara, Takashi Hoshi, Masayoshi Ando

    Tetrahedron Letters   42 ( 1 )   65 - 67   2001.1

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    The stereoselective formal synthesis of (+)-isolaurepinnacin is described. The required key oxepene skeleton possessing cis-oriented alkyl substituents at the α,ω-positions was stereoselectively constructed via the cyclization of the corresponding hydroxy epoxide promoted by the (Bu3Sn)2O/Zn(OTf)2 system. © 2000 Elsevier Science Ltd.

    DOI: 10.1016/S0040-4039(00)01880-3

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  • The first total synthesis of (-)-solanapyrone E based on domino Michael strategy

    H Hagiwara, K Kobayashi, S Miya, T Hoshi, T Suzuki, M Ando

    ORGANIC LETTERS   3 ( 2 )   251 - 254   2001.1

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    Language:English   Publisher:AMER CHEMICAL SOC  

    [GRAPHICS]
    A phytotoxin, solanapyrone E, has been synthesized from the decalone prepared by the domino Michael reaction of the kinetic enolate of optically pure acetylcyclohexene with methyl crotonate, After several transformations on the decalone ring, condensation of a methyl acetoacetate equivalent installed a pyrone moiety and introduction of a hydroxymethyl unit into the pyrone ring furnished solanapyrone E.

    DOI: 10.1021/ol006893h

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  • The first total synthesis of (-)-solanapyrone E based on domino Michael strategy

    H Hagiwara, K Kobayashi, S Miya, T Hoshi, T Suzuki, M Ando

    ORGANIC LETTERS   3 ( 2 )   251 - 254   2001.1

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    Language:English   Publisher:AMER CHEMICAL SOC  

    [GRAPHICS]
    A phytotoxin, solanapyrone E, has been synthesized from the decalone prepared by the domino Michael reaction of the kinetic enolate of optically pure acetylcyclohexene with methyl crotonate, After several transformations on the decalone ring, condensation of a methyl acetoacetate equivalent installed a pyrone moiety and introduction of a hydroxymethyl unit into the pyrone ring furnished solanapyrone E.

    DOI: 10.1021/ol006893h

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  • Heterogeneous Heck Reaction Catalyzed by Pd/C in Ionic Liquid(共著)

    HAGIWARA H, SHIMIZU Y, HOSHI T, SUZUKI T, ANDO M, OHKUBO K, YOKOYAMA C

    Tetrahedron Lett.   42 ( 26 )   4349 - 4351   2001

  • Short-step Synthesis of Some Santanolides, Dehydroisoerivanin, Isoerivanin, Ludovicin C, and 1,3-Dihydroxyarubusculin B by the Use of the Organoselenium Reduction Method of Epoxy Ketones(共著)

    Hetereocycles   54 ( 2 )   865 - 870   2001

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  • Formal Synthesis of (+)-Isolaurepinnacin(共著)

    SUZUKI T, MATSUMURA R, OKU K, TAGUCHI K, HAGIWARA H, HOSHI T, ANDO M

    Tetrahedron Lett.   42 ( 1 )   65 - 67   2001

  • 5. Short-step Synthesis of Some Santanolides, Dehydroisoerivanin, Isoerivanin, -Dihydroxyarubusculin B by the Use of the Organoselenium,3Ludovicin C, and 1 Reduction Method of Epoxy Ketones"jointly worked"

    Hetereocycles   54 ( 2 )   865 - 870   2001

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  • First Total Synthesis of Chapecoderin A: Absoluted Configuration of the Natural Product"jointly worked "

    Tetrahedron Lett.   42 ( 43 )   7629 - 7631   2001

  • First Total Synthesis of Chapecoderin A: Absoluted Configuration of the Natural Product(共著)

    HAGIWARA H, TAKEUCHI F, HOSHI T, SUZUKI T, ANDO M

    Tetrahedron Lett.   42 ( 43 )   7629 - 7631   2001

  • Heterogeneous Heck Reaction Catalyzed by Pd/C in Ionic Liquid"jointly worked"

    Tetrahedron Lett.   42 ( 26 )   4349 - 4351   2001

  • Cyclization of hydroxy epoxides promoted by (Bu3Sn)(2)O/Lewis acid: efficient synthesis of oxepanes

    R Matsumura, T Suzuki, K Sato, K Oku, H Hagiwara, T Hoshi, M Ando, VP Kamat

    TETRAHEDRON LETTERS   41 ( 40 )   7701 - 7704   2000.9

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    Cyclization of hydroxy epoxides mediated by a (Bu3Sn)(2)O/Lewis acid system proceeded via an S(N)2 process and exo mode to provide the corresponding seven-membered cyclic ethers in high yield. (C) 2000 Elsevier science Ltd. All rights reserved.

    DOI: 10.1016/S0040-4039(00)01345-9

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  • Stereospecific Synthesis of -cis- and -trans-Disubstituted Oxepanes"jointly worked"

    Tetrahedron Lett.   41 ( 40 )   7701 - 7704   2000

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  • Stereospecific Synthesis of ,-cis- and ,-trans-Disubstituted Oxepanes(共著)

    Tetrahedron Lett.   41 ( 40 )   7701 - 7704   2000

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  • Cyclization of Hydroxy Epoxides Promoted by (Bu3Sn)2O/Lewis Acid: Efficient Synthesis of Oxepanes"jointly worked"

    Tetrahedron Lett.   41 ( 40 )   7701 - 7704   2000

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Research Projects

  • Stereoselective Synthesis of Natural Products

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    Grant type:Competitive

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  • 天然有機化合物の立体選択的合成

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    Grant type:Competitive

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  • 新規有機変換反応の開発

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Teaching Experience

  • 有機素材物性解析

    2021
    Institution name:新潟大学

  • 技術文献リサーチC

    2020
    Institution name:新潟大学

  • 技術文献リサーチD

    2020
    Institution name:新潟大学

  • 技術文献リサーチB

    2020
    Institution name:新潟大学

  • 技術文献リサーチA

    2020
    Institution name:新潟大学

  • 有機化学実験(工)

    2019
    Institution name:新潟大学

  • 総合工学概論

    2018
    Institution name:新潟大学

  • 基礎有機化学

    2017
    Institution name:新潟大学

  • 工学リテラシー入門(化学材料分野)

    2017
    -
    2022
    Institution name:新潟大学

  • 総合技術科学演習

    2017
    -
    2021
    Institution name:新潟大学

  • 材料生産システム博士セミナーⅢ

    2015
    Institution name:新潟大学

  • 材料生産システム博士特定研究Ⅲ

    2015
    Institution name:新潟大学

  • 大型機器分析技術

    2015
    Institution name:新潟大学

  • 外国語論文解説・討論Ⅲ

    2015
    Institution name:新潟大学

  • 材料生産システム博士セミナーⅡ

    2014
    Institution name:新潟大学

  • 材料生産システム博士特定研究Ⅱ

    2014
    Institution name:新潟大学

  • 中間発表

    2014
    Institution name:新潟大学

  • 外国語論文解説・討論Ⅱ

    2014
    Institution name:新潟大学

  • 最先端技術を支える化学 I

    2013
    Institution name:新潟大学

  • 素材生産科学コース演習

    2013
    Institution name:新潟大学

  • 外国語論文解説・討論Ⅰ

    2013
    Institution name:新潟大学

  • 材料生産システム博士セミナーⅠ

    2013
    Institution name:新潟大学

  • 材料生産システム博士特定研究Ⅰ

    2013
    Institution name:新潟大学

  • 素材生産科学文献詳読Ⅱ

    2012
    -
    2015
    Institution name:新潟大学

  • 素材生産科学セミナーⅠ

    2012
    -
    2015
    Institution name:新潟大学

  • 材料生産システム特定研究Ⅱ

    2012
    -
    2015
    Institution name:新潟大学

  • 研究発表演習・発表

    2012
    -
    2015
    Institution name:新潟大学

  • 素材生産科学セミナーⅡ

    2012
    -
    2015
    Institution name:新潟大学

  • 素材生産科学文献詳読Ⅰ

    2012
    -
    2015
    Institution name:新潟大学

  • 素材生産科学特別演習

    2012
    -
    2015
    Institution name:新潟大学

  • 材料生産システム特定研究Ⅰ

    2012
    -
    2015
    Institution name:新潟大学

  • 有機素材合成

    2011
    -
    2014
    Institution name:新潟大学

  • 卒業研修

    2009
    Institution name:新潟大学

  • 自然科学総論Ⅱ

    2009
    -
    2019
    Institution name:新潟大学

  • 工学リテラシー入門(化学システム工学科)

    2009
    -
    2016
    Institution name:新潟大学

  • 化学技術英語

    2008
    Institution name:新潟大学

  • 化学システム工学入門

    2008
    Institution name:新潟大学

  • 有機合成化学

    2007
    Institution name:新潟大学

  • 卒業研究

    2007
    Institution name:新潟大学

  • 有機反応化学

    2007
    Institution name:新潟大学

  • 日本事情自然系B

    2007
    Institution name:新潟大学

  • 精密分子設計化学

    2007
    -
    2022
    Institution name:新潟大学

  • 論文輪講I

    2007
    -
    2019
    Institution name:新潟大学

  • 論文輪講II

    2007
    -
    2018
    Institution name:新潟大学

  • 有機化学実験

    2007
    -
    2018
    Institution name:新潟大学

  • 分子設計化学

    2007
    -
    2017
    Institution name:新潟大学

  • 有機素材物性解析

    2007
    -
    2014
    Institution name:新潟大学

  • 最先端技術を支える化学 II

    2007
    -
    2011
    Institution name:新潟大学

  • 卒業基礎研究

    2007
    -
    2008
    Institution name:新潟大学

  • 応用化学実習

    2007
    Institution name:新潟大学

  • 統合化学入門

    2007
    Institution name:新潟大学

  • リメディアル演習(化学システム工学)

    2007
    Institution name:新潟大学

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