Updated on 2024/10/07

写真a

 
KAWACHI Izumi
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Associate Professor
Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine Molecular Neuroscience and Brain Diseases Associate Professor
Title
Associate Professor
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Degree

  • 博士(医学) ( 2002.3   新潟大学 )

Research Interests

  • multiple sclerosis

  • neurology

  • IgG4-related disease

  • ANCA associated vasculitis

  • dementia

  • autoimmune encephalitis

  • autoimmune pachymeningitis

  • myasthenia gravis

  • neuropathology

  • medical education

  • innate immunology

  • neurodegenerative disorders

  • neuroimmunology

  • neuromyelitis optica

Research Areas

  • Life Science / Neurology

  • Life Science / Immunology

Research History (researchmap)

  • 新潟大学 医歯学総合研究科 分子細胞医学専攻 分子情報医学   准教授

    2019.6

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  • Niigata University   Medical and Dental Hospital   Lecturer

    2015.1 - 2019.5

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  • 新潟大学医学部附属病院 脳神経内科学   病院講師

    2010.10 - 2014.12

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  • Niigata University   University Medical and Dental Hospital   Assistant Professor

    2007.4 - 2014.12

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  • Niigata University   Graduate School of Medical and Dental Sciences Biomedical Sciences   Assistant Professor

    2007.4 - 2014.12

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  • Niigata University   Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine   Assistant Professor

    2007.4 - 2014.12

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  • Washington University in St. Louis, School of Medicine, Department of Immunology and Pathology   Researcher

    2003.7 - 2006.2

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Research History

  • Niigata University   Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine Molecular Neuroscience and Brain Diseases   Associate Professor

    2019.6

  • Niigata University   University Medical and Dental Hospital Neurology   Lecturer

    2019.4 - 2019.5

  • Niigata University   University Medical and Dental Hospital Neurology   Lecturer

    2015.1 - 2019.3

  • Niigata University   Graduate School of Medical and Dental Sciences Biomedical Sciences   Assistant Professor

    2007.4 - 2019.3

  • Niigata University   Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine   Assistant Professor

    2007.4 - 2019.3

  • Niigata University   University Medical and Dental Hospital   Assistant Professor

    2007.4 - 2014.12

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Education

  • Niigata University   Graduate School of Medicine

    1998.4 - 2002.3

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  • Niigata University   Faculty of Medicine   School of Medicine

    1987.4 - 1993.3

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Professional Memberships

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Committee Memberships

  • 日本神経学会   2024年度日本神経学会関東・甲信越地区生涯教育講演会プログラム委員会 (委員)  

    2024.3   

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  •   18th International Congress of Neuroimmunology 2025 (ISNI 2025): Award Selection Committee  

    2023.12   

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  •   18th International Congress of Neuroimmunology 2025 (ISNI 2025): Publication Committee (Chair)  

    2023.12   

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  • 日本神経免疫学会   内保連委員会副委員長  

    2023.9   

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    Committee type:Academic society

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  • 日本神経免疫学会   評議員選任委員会委員  

    2023.9   

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    Committee type:Academic society

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  • 日本神経免疫学会   理事  

    2023.9   

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    Committee type:Academic society

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  • 日本母性内科学会   幹事  

    2023.8   

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  • 日本神経学会   教育委員会委員  

    2023.6   

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  • 日本神経学会   将来構想委員会委員  

    2023.4   

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  • 日本神経学会   母性神経学セクションコアメンバー  

    2023.1   

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  • 日本医学教育学会   認定医学教育専門家  

    2023.1   

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  • 日本神経学会   専門医認定委員会委員  

    2022.11   

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  • 日本神経病理学会   用語委員会委員  

    2022.8   

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    Committee type:Academic society

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  • 医療系大学間共用試験実施評価機構   医学系OSCE課題作成小委員会委員  

    2021.11   

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  • 日本神経免疫学会   レジストリ検討委員会委員  

    2021.4   

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  • 新潟県   新潟水俣病施策推進審議会委員  

    2020.2   

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    Committee type:Municipal

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  • 日本シミュレーター医療教育学会   評議員  

    2019.9   

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    Committee type:Academic society

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  • 特定非営利活動法人 日本多発性硬化症ネットワーク   評議員  

    2019.5   

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    Committee type:Other

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  • 日本神経病理学会   指導医・認定医  

    2019.4   

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    Committee type:Academic society

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  • 日本神経学会   代議員  

    2017.9   

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    Committee type:Academic society

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  • 日本神経病理学会   代議員  

    2016.10   

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  • 日本神経治療学会   評議員  

    2016.5   

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    Committee type:Academic society

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  • 日本内科学会   総合内科専門医  

    2015.12   

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    Committee type:Academic society

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  • 日本神経学会   多発性硬化症診療ガイドライン作成委員会委員  

    2014.1   

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    Committee type:Academic society

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  • 日本神経免疫学会   MS・NMOSD委員会委員  

    2013.4   

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    Committee type:Academic society

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  • 日本多発性硬化症協会   医学顧問  

    2011.8   

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    Committee type:Other

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  • 日本神経学会   指導医  

    2009.5   

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  • 日本神経免疫学会   評議員  

    2009.4   

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    Committee type:Academic society

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  • 日本内科学会   認定医  

    2004.4   

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  • 日本神経学会   専門医  

    1997.7   

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  • 日本認知症学会   専門医・指導医  

    2024.4   

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  • 日本医学教育評価機構   評価員  

    2021.8 - 2024.3   

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Studying abroad experiences

  • Washington University in St. Louis, School of Medicine, Department of Immunology and Pathology   Research associate

    2003.7 - 2006.2

 

Papers

  • Safety and Effectiveness of Satralizumab in Japanese Patients with Neuromyelitis Optica Spectrum Disorder: A 6-month Interim Analysis of Post-marketing Surveillance Reviewed

    Takashi Yamamura, Noriko Isobe, Izumi Kawachi, Chiyoko Nohara, Yusei Miyazaki, Minami Tomita, Takahiko Tsumuraya, Katsuhisa Yamashita, Jin Nakahara, Ichiro Nakashima, Kazuo Fujihara

    Neurology and Therapy   2024.7

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s40120-024-00640-7

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    Other Link: https://link.springer.com/article/10.1007/s40120-024-00640-7/fulltext.html

  • Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ Reviewed

    Akihiro Nakajima, Fumihiro Yanagimura, Etsuji Saji, Hiroshi Shimizu, Yasuko Toyoshima, Kaori Yanagawa, Musashi Arakawa, Mariko Hokari, Akiko Yokoseki, Takahiro Wakasugi, Kouichirou Okamoto, Hirohide Takebayashi, Chihiro Fujii, Kyoko Itoh, Yo-ichi Takei, Shinji Ohara, Mitsunori Yamada, Hitoshi Takahashi, Masatoyo Nishizawa, Hironaka Igarashi, Akiyoshi Kakita, Osamu Onodera, Izumi Kawachi

    Acta Neuropathologica   147 ( 1 )   2024.4

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s00401-024-02725-x

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    Other Link: https://link.springer.com/article/10.1007/s00401-024-02725-x/fulltext.html

  • Acute respiratory failure caused by brainstem demyelinating lesions in an older patient with an atypical relapsing autoimmune disorder Reviewed

    Shoko Hongo, Hiroshi Shimizu, Etsuji Saji, Akihiro Nakajima, Kouichirou Okamoto, Izumi Kawachi, Osamu Onodera, Akiyoshi Kakita

    Neuropathology   2024.4

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    An 84‐year‐old man presented with somnolence, dysphagia, and right hemiplegia, all occurring within a month, approximately one year after initial admission due to subacute, transient cognitive decline suggestive of acute disseminated encephalomyelitis involving the cerebral white matter. Serial magnetic resonance imaging (MRI) studies over that period revealed three high‐intensity signal lesions on fluid‐attenuated inversion recovery images, appearing in chronological order in the left upper and left lower medulla oblongata and left pontine base. Despite some clinical improvement following methylprednisolone pulse therapy, the patient died of respiratory failure. Autopsy revealed four fresh, well‐defined lesions in the brainstem, three of which corresponded to the lesions detected radiologically. The remaining lesion was located in the dorsal medulla oblongata and involved the right solitary nucleus. This might have appeared at a later disease stage, eventually causing respiratory failure. Histologically, all four lesions showed loss of myelin, preservation of axons, and infiltration of lymphocytes, predominantly CD8‐positive T cells, consistent with the histological features of autoimmune demyelinating diseases, particularly the confluent demyelination observed in the early and acute phases of multiple sclerosis (MS). In the cerebral white matter, autoimmune demyelination appeared superimposed on ischemic changes, consistent with the cerebrospinal fluid (CSF) and MRI findings on initial admission. No anti‐AQP4 or MOG antibodies or those potentially causing autoimmune encephalitis/demyelination were detected in either the serum or CSF. Despite several similarities to MS, such as the relapsing–remitting disease course and lesion histology, the entire clinicopathological picture in the present patient, especially the advanced age at onset and development of brainstem lesions in close proximity within a short time frame, did not fit those of MS or other autoimmune diseases that are currently established. The present results suggest that exceptionally older individuals can be affected by an as yet unknown inflammatory demyelinating disease of the CNS.

    DOI: 10.1111/neup.12976

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  • Effect of Infliximab on Chronic Progressive Behcet's Disease: Influence of the Timing of Introduction on the Patient Outcome. Reviewed

    Shunsei Hirohata, Hirotoshi Kikuchi, Tetsuji Sawada, Masataka Kuwana, Izumi Kawachi, Yohei Kirino, Yoshiaki Ishigatsubo, Mitsuhiro Takeno

    Internal medicine (Tokyo, Japan)   63 ( 4 )   481 - 486   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society of Internal Medicine  

    Objectives Chronic progressive neuro-Behcet's disease (CPNB) is characterized by progressive deterioration leading to disability. Methotrexate (MTX) has been shown to have beneficial effects on CPNB. However, while infliximab has been found to be effective for patients with inadequate responses to MTX, the appropriate timing for the introduction of infliximab remains unclear. We explored the effects of intervals before the introduction of infliximab on the functional outcome. Methods A retrospective analysis was performed for patients with CPNB who received infliximab and were followed up until October 2015. Functional disability was rated by the Steinbrocker functional classification as used in rheumatoid arthritis. Correlations between the outcomes and intervals before the introduction of infliximab were then analyzed by Spearman's rank correlation test. Patients Eleven patients with CPNB (8 men, 3 women, age 35.2±9.3 years old [mean±standard deviation]) who met the international classification criteria for Behcet's disease were included. Results All 11 patients had received MTX prior to infliximab. The intervals from the onset to the introduction of infliximab and the follow-up periods were 26.6±35.1 months and 65.2±43.6 months [mean±standard deviation], respectively. Among the 11 patients, 2 still showed progression after the introduction of infliximab. The functional disability grades after infliximab treatment were significantly correlated with the intervals from the onset of CPNB to the introduction of infliximab (r=0.6177, p=0.0476). Conclusion The results indicate that the delayed introduction of infliximab leads to irreversible functional disability in CPNB. Thus, it is recommended that infliximab be administered as soon as possible for CPNB patients with inadequate responses to MTX.

    DOI: 10.2169/internalmedicine.1969-23

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  • Health-related quality of life in Japanese patients with multiple sclerosis. Reviewed International journal

    Masaaki Niino, Shoko Fukumoto, Tatsusada Okuno, Nobuo Sanjo, Hikoaki Fukaura, Masahiro Mori, Takashi Ohashi, Hideyuki Takeuchi, Yuko Shimizu, Juichi Fujimori, Izumi Kawachi, Jun-Ichi Kira, Eri Takahashi, Yusei Miyazaki, Nobuhiro Mifune

    Journal of neurology   270 ( 2 )   1011 - 1018   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: Neurological disabilities, especially physical issues, can adversely affect the daily lives of people with multiple sclerosis (MS) and negatively impact their health-related quality of life (HRQOL). On the other hand, physical and psychiatric symptoms are variable in people with MS, and QOL can be influenced by cultural and educational background. This study aimed to evaluate the association of HRQOL with disabilities, fatigue, and depression in Japanese subjects with MS. METHODS: Evaluation of HRQOL, fatigue, and depression was performed in 184 Japanese individuals with MS, using the Functional Assessment of MS (FAMS), Fatigue Severity Scale (FSS), and Beck Depression Inventory-Second Edition (BDI-II), respectively. RESULTS: Multiple linear regression analysis demonstrated negative correlations of the Expanded Disability Status Scale (EDSS) with scores on the FAMS subscales of mobility, symptoms, thinking and fatigue, total FAMS, and additional concerns. The FSS score had negative correlations with mobility, symptoms, emotional well-being, thinking and fatigue, total FAMS, and additional concerns. There were negative correlations between BDI-II scores and all items of FAMS. CONCLUSIONS: HRQOL had relatively close correlations with disabilities and fatigue, and depression had an especially close relationship with HRQOL.

    DOI: 10.1007/s00415-022-11453-9

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  • Biallelic <i>COX10</i> Mutations and <i>PMP22</i> Deletion in a Family With Leigh Syndrome and Hereditary Neuropathy With Liability to Pressure Palsy Reviewed International journal

    Yasuko Kuroha, Takanobu Ishiguro, Mari Tada, Norikazu Hara, Kei Murayama, Izumi Kawachi, Kensaku Kasuga, Akinori Miyashita, Arika Hasegawa, Tetsuya Takahashi, Nae Matsubara, Osamu Onodera, Akiyoshi Kakita, Ryoko Koike, Takeshi Ikeuchi

    Neurology Genetics   8 ( 5 )   e200030 - e200030   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    Objectives

    Leigh syndrome is a progressive encephalopathy characterized by symmetrical lesions in brain. This study aimed to investigate the clinicopathologic and genetic characteristics of a family with Leigh syndrome and hereditary neuropathy with liability to pressure palsy (HNPP).

    Methods

    Data from a Japanese family's clinical features, MRIs, muscle biopsy, and an autopsy were analyzed. A whole-exome sequence was performed, as well as real-time PCR analysis to determine copy number variations and Western blot analyses.

    Results

    The proband and her 2 siblings developed spastic paraplegia and mental retardation during childhood. The proband and her sister had peripheral neuropathy, whereas their father developed compression neuropathy. Leigh encephalopathy was diagnosed neuropathologically. Brain MRI revealed changes in cerebral white matter as well as multiple lesions in the brainstem and cerebellum. Muscle biopsy revealed type 2 fiber uniformity and decreased staining of cytochrome c oxidase. The COX10 missense mutation was identified through whole-exome sequence. A 1.4-Mb genomic deletion extending from intron 5 of COX10 to PMP22 was detected.

    Discussion

    These findings suggest that in this family, Leigh syndrome is associated with a mitochondrial respiratory chain complex IV deficiency caused by biallelic COX10 mutations coexisting with HNPP caused by heterozygous PMP22 deletion.

    DOI: 10.1212/nxg.0000000000200030

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  • Treatment Status and Healthcare Cost Trends for Patients with Multiple Sclerosis in Japan: A Claims Database Analysis Reviewed

    Izumi Kawachi, Hiromichi Otaka, Kosuke Iwasaki, Tomomi Takeshima, Kengo Ueda

    Neurology and Therapy   11 ( 3 )   1253 - 1268   2022.9

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s40120-022-00374-4

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    Other Link: https://link.springer.com/article/10.1007/s40120-022-00374-4/fulltext.html

  • Systematic review and network meta‐analysis comparing ofatumumab with other disease‐modifying therapies available in Japan for the treatment of patients with relapsing multiple sclerosis Reviewed

    Christopher Drudge, Melody Zhao, Satoru Tanaka, Nozomu Tanaka, Hiromichi Otaka, Izumi Kawachi, Dieter A. Häring, Róisín Brennan, Nicholas Adlard, Imtiaz A. Samjoo

    Clinical and Experimental Neuroimmunology   2022.7

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/cen3.12717

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cen3.12717

  • Autoimmunity to glutamate receptor channels Invited Reviewed

    Izumi Kawachi

    Neurology and Clinical Neuroscience   12 ( 3 )   129 - 136   2022.6

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Glutamate and its receptors are involved in pleiotropic roles including experience‐dependent synaptic plasticity and brain development as the main fast excitatory neurotransmitters in the central nervous system. There are two main families of the glutamate receptors: (1) ionotropic glutamate receptors (iGluRs) that are ligand‐gated ion channel receptors accessible for fast synaptic transmission, and (2) metabotropic glutamate receptors (mGluRs) that are G‐protein‐coupled receptors modulating slow synaptic transmission through intracellular second messengers. Here, we summarize the current concepts of autoimmunity to these glutamate receptors in neurological disorders: anti‐GluN1 subunit of N‐methyl‐<sub>D</sub>‐aspartate receptor (NMDARs) for anti‐NMDAR encephalitis, anti‐GluA1 and GluA2 subunits of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPARs) for anti‐AMPAR encephalitis, and anti‐mGluR5 subunit for Ophelia syndrome. Most identified autoimmunity to glutamate receptors can lead to unique synaptopathies or neuronal antibody‐mediated encephalopathies. Evidence‐based optimal management guidelines and new disease‐modifying therapies need to be developed for patients with autoimmune encephalitis including anti‐glutamate receptor encephalitis.

    DOI: 10.1111/ncn3.12650

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ncn3.12650

  • A Principal Component Analysis Approach to Estimate the Disability Status for Patients with Multiple Sclerosis Using Japanese Claims Data Reviewed

    Izumi Kawachi, Hiromichi Otaka, Kosuke Iwasaki, Tomomi Takeshima, Kengo Ueda

    Neurology and Therapy   11 ( 1 )   385 - 396   2022.3

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s40120-022-00324-0

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    Other Link: https://link.springer.com/article/10.1007/s40120-022-00324-0/fulltext.html

  • HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data Reviewed

    Mitsuru Watanabe, Yuri Nakamura, Shinya Sato, Masaaki Niino, Hikoaki Fukaura, Masami Tanaka, Hirofumi Ochi, Takashi Kanda, Yukio Takeshita, Takanori Yokota, Yoichiro Nishida, Makoto Matsui, Shigemi Nagayama, Susumu Kusunoki, Katsuichi Miyamoto, Masanori Mizuno, Izumi Kawachi, Etsuji Saji, Takashi Ohashi, Shun Shimohama, Shin Hisahara, Kazutoshi Nishiyama, Takahiro Iizuka, Yuji Nakatsuji, Tatsusada Okuno, Kazuhide Ochi, Akio Suzumura, Ken Yamamoto, Yuji Kawano, Shoji Tsuji, Makoto Hirata, Ryuichi Sakate, Tomonori Kimura, Yuko Shimizu, Akiko Nagaishi, Kazumasa Okada, Fumie Hayashi, Ayako Sakoda, Katsuhisa Masaki, Koji Shinoda, Noriko Isobe, Takuya Matsushita, Jun-ichi Kira

    Scientific Reports   11 ( 1 )   2021.12

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    HLA genotype-clinical phenotype correlations are not established for multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). We studied HLA-DRB1/DPB1 genotype–phenotype correlations in 528 MS and 165 NMOSD cases using Japan MS/NMOSD Biobank materials. HLA-DRB1*04:05, DRB1*15:01 and DPB1*03:01 correlated with MS susceptibility and DRB1*01:01, DRB1*09:01, DRB1*13:02 and DPB1*04:01 were protective against MS. HLA-DRB1*15:01 was associated with increased optic neuritis and cerebellar involvement and worsened visual and pyramidal functional scale (FS) scores, resulting in higher progression index values. HLA-DRB1*04:05 was associated with younger onset age, high visual FS scores, and a high tendency to develop optic neuritis. HLA-DPB1*03:01 increased brainstem and cerebellar FS scores. By contrast, HLA-DRB1*01:01 decreased spinal cord involvement and sensory FS scores, HLA-DRB1*09:01 decreased annualized relapse rate, brainstem involvement and bowel and bladder FS scores, and HLA-DRB1*13:02 decreased spinal cord and brainstem involvement. In NMOSD, HLA-DRB1*08:02 and DPB1*05:01 were associated with susceptibility and DRB1*09:01 was protective. Multivariable analysis revealed old onset age, long disease duration, and many relapses as independent disability risks in both MS and NMOSD, and HLA-DRB1*15:01 as an independent risk only in MS. Therefore, both susceptibility and protective alleles can influence the clinical manifestations in MS, while such genotype–phenotype correlations are unclear in NMOSD.

    DOI: 10.1038/s41598-020-79833-7

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    Other Link: http://www.nature.com/articles/s41598-020-79833-7

  • Correlation of the Symbol Digit Modalities Test with the Quality of Life and Depression in Japanese Patients with Multiple Sclerosis Reviewed

    Masaaki Niino, Shoko Fukumoto, Tatsusada Okuno, Nobuo Sanjo, Hikoaki Fukaura, Masahiro Mori, Takashi Ohashi, Hideyuki Takeuchi, Yuko Shimizu, Juichi Fujimori, Izumi Kawachi, Jun-ichi Kira, Eri Takahashi, Yusei Miyazaki, Nobuhiro Mifune

    Multiple Sclerosis and Related Disorders   103427 - 103427   2021.11

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.msard.2021.103427

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  • Visual outcome of aquaporin-4 antibody-positive optic neuritis with maintenance therapy. Reviewed

    Satoshi Ueki, Tetsuhisa Hatase, Megumi Kiyokawa, Izumi Kawachi, Etsuji Saji, Osamu Onodera, Takeo Fukuchi, Hironaka Igarashi

    Japanese journal of ophthalmology   65 ( 5 )   699 - 703   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    PURPOSE: To assess the effect of maintenance therapy on visual outcomes in preventing recurrences one year after first onset in patients with aquaporin-4 antibody (AQP4Ab)-positive optic neuritis. STUDY DESIGN: Retrospective study. METHODS: The medical charts of 56 patients with optic neuritis (22 with AQP4Ab-positive and 34 with AQP4Ab-negative) at Niigata University Medical and Dental Hospital were retrospectively analyzed. Clinical characteristics, including visual acuity and number of recurrences one year after first onset, were compared among patients who were AQP4Ab-positivie with and those without maintenance therapy such as oral prednisolone and azathioprine, as well as those who were AQP4Ab-negative. RESULTS: The mean ages were 49.3 and 45.2 years in the AQP4Ab-positive and the AQP4Ab-negative groups. The female to male ratio was 21:1 and 18:16 in the two groups, respectively. Multiple between-group comparison showed a statistically significant difference in visual acuity one year after first onset between the AQP4Ab-positive without maintenance therapy group and the AQP4Ab-negative group (0.05 (median, same applies below) vs. 1.0, p < 0.01). There was also a statistically significant difference in the number of recurrences in the year after first onset between the AQP4Ab-positive with and without maintenance therapy groups (1 vs. 0, p < 0.01). CONCLUSION: This study demonstrates that patients with AQP4Ab-positive optic neuritis without maintenance therapy had the poorest visual acuity and the most recurrences one year after first onset. These results indicate that reducing the number of recurrences with maintenance therapy could improve the visual outcomes in patients with AQP4Ab-positive optic neuritis.

    DOI: 10.1007/s10384-021-00858-0

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    Other Link: https://link.springer.com/article/10.1007/s10384-021-00858-0/fulltext.html

  • Oculopharyngodistal myopathy with coexisting histology of systemic neuronal intranuclear inclusion disease: Clinicopathologic features of an autopsied patient harboring CGG repeat expansions in LRP12. Reviewed International journal

    Rie Saito, Hiroshi Shimizu, Takeshi Miura, Norikazu Hara, Naomi Mezaki, Yo Higuchi, Akinori Miyashita, Izumi Kawachi, Kazuhiro Sanpei, Yoshiaki Honma, Osamu Onodera, Takeshi Ikeuchi, Akiyoshi Kakita

    Acta neuropathologica communications   8 ( 1 )   75 - 75   2020.6

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  • Recent transition of medical cost and relapse rate of multiple sclerosis in Japan based on analysis of a health insurance claims database. Reviewed

    Kawachi I, Okamoto S, Sakamoto M, Ohta H, Nakamura Y, Iwasaki K, Yoshida M, Hiroi S, Ogino M

    BMC neurology   19 ( 1 )   324   2019.12

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    Authorship:Lead author, Corresponding author  

    DOI: 10.1186/s12883-019-1534-9

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  • Neuropathological features of “non‐motor” symptoms in multiple sclerosis and neuromyelitis optica Invited Reviewed

    KAWACHI Izumi

    Clinical and Experimental Neuroimmunology   10 ( 3 )   161 - 168   2019.8

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    © 2019 Japanese Society for Neuroimmunology Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are the two main autoimmune demyelinating disorders of the central nervous system. MS is defined as autoimmune oligodendrocytopathy (unknown autoantigens), and NMOSD is defined as autoimmune astrocytopathy or aquaporin-4 channelopathy. Both diseases can occur throughout the central nervous system, and do often cause various “motor” and “non-motor” symptoms. “Non-motor” symptoms, including cognitive impairment, fatigue, pain and neuropsychological symptoms (e.g. depression, loneliness and anxiety), have gained renewed attention in MS and NMOSD since the past three decades, because they influence a patient&#039;s competence in daily life activities, including the participation in social activities and their employment status. Herein, we summarize the current concepts of the neuropathological processes of these “non-motor” symptoms in MS and NMOSD. These concepts help to define the novel disease-specific mechanisms of the two diseases, and to improve the quality of daily life of patients with MS and NMOSD.

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  • Neurodegeneration in multiple sclerosis and neuromyelitis optica Reviewed

    Izumi Kawachi, Hans Lassmann

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   88 ( 2 )   137 - 145   2017.2

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    Multiple sclerosis (MS) and neuromyelitis optica (NMO) are autoimmune demyelinating diseases of the central nervous system (CNS), having distinct immunological and pathological features. They have two pathogenic components, 'inflammation' and 'neurodegeneration', with different degrees of severity and pathogenetic mechanisms. The target antigen of autoimmunity in NMO is the water channel aquaporin-4 (AQP4), and antibodies directed against this antigen result in astrocyte damage. MS is a disease primarily affecting myelin and oligodendrocytes, but thus far, no MS-specific autoantigen has been identified. The distinct inflammatory processes in these diseases may trigger cascades of events leading to disease-specific neurodegeneration. Damage of the CNS tissue appears to be amplified by mechanisms that are in part shared by the two conditions and involve oxidative burst activation in microglia/macrophages, mitochondrial damage and axonal energy failure, Wallerian degeneration and meningeal inflammation. However, they appear to differ regarding the nature of the inflammatory response, the type and extent of cortical injury, and the type of astrocyte reaction and damage. Here, we provide a detailed comparison of the pathology between MS and NMO, which may help to define shared and disease-specific mechanisms of neurodegeneration in these diseases.

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  • Clinical characteristics of autoimmune optic neuritis Invited Reviewed

    Izumi Kawachi

    Clinical and Experimental Neuroimmunology   8   8 - 16   2017.1

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    Autoimmune disorders of the central nervous system often involve autoimmune inflammation of the anterior visual pathways. Autoimmune optic neuritis can be categorized as: (i) isolated optic neuritis
    (ii) relapsing isolated optic neuritis: (iii) chronic relapsing inflammatory optic neuropathy
    (iv) neuromyelitis optica spectrum disorders-associated optic neuritis
    or (v) multiple sclerosis-associated optic neuritis. Studies of serum-specific autoantibodies, such as aquaporin-4 and myelin oligodendrocyte glycoprotein, have revealed some underlying mechanisms of autoimmune optic neuritis. However, the etiology and pathogenesis of most cases of autoimmune optic neuritis remain unclear. The following clinical features of autoimmune optic neuritis are profoundly affected by the unique structure of the human anterior visual pathways: (i) vulnerability to swelling of the intracanalicular optic nerve as a result of the limited space within the bony canal
    (ii) inflammatory cell infiltration through the subarachnoid space, pia and pial septa
    (iii) compartmentalized dynamics of cerebrospinal fluid as a result of the cul-de-sac anatomy of the optic nerve
    (iv) permeability of the prelaminar optic nerve head as a result of the lack of classical blood–brain barrier characteristics
    and (v) retinal abnormalities, which are a diagnostic window of neurodegenerative processes of the optic nerves and/or brain. Future studies are required to configure a systemic nosology for optic neuritis with international consensus, elucidate specific diagnostic biomarkers, carry out clinical trials of the acute and chronic phases of the disease etiologies, and elucidate possible neuroprotective and remyelinating treatments.

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  • Safety and efficacy of thalidomide in patients with POEMS syndrome: a multicentre, randomised, double-blind, placebo-controlled trial Reviewed

    Sonoko Misawa, Yasunori Sato, Kanako Katayama, Kengo Nagashima, Reiko Aoyagi, Yukari Sekiguchi, Gen Sobue, Haruki Koike, Ichiro Yabe, Hidenao Sasaki, Osamu Watanabe, Hiroshi Takashima, Masatoyo Nishizawa, Izumi Kawachi, Susumu Kusunoki, Yoshiyuki Mitsui, Seiji Kikuchi, Ichiro Nakashima, Shu-ichi Ikeda, Nobuo Kohara, Takashi Kanda, Jun-ichi Kira, Hideki Hanaoka, Satoshi Kuwabara

    LANCET NEUROLOGY   15 ( 11 )   1129 - 1137   2016.10

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    Background Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare cause of demyelinating neuropathy, with multi-organ involvement characterised by plasma cell dyscrasia and VEGF overproduction. No treatments have been established for patients with POEMS syndrome who are not eligible for stem-cell transplantation. Thalidomide suppresses VEGF and plasma cell proliferation. We aimed to assess the safety and efficacy of thalidomide for the treatment of POEMS syndrome.
    Methods We did a randomised, double-blind, placebo-controlled, phase 2/3 trial at 12 hospitals in Japan. Adults (age &gt;= 20 years) with POEMS syndrome who were ineligible for autotransplantation were randomly assigned (1:1) by a minimisation method to treatment with oral dexamethasone (12 mg/m(2) per day on the first 4 days of every 28-day cycle) plus either oral thalidomide (200 mg daily) or placebo for six cycles. All study personnel and patients were masked to treatment allocation. The primary endpoint was the reduction rate of serum VEGF concentrations at 24 weeks. Analysis was by intention to treat. This study is registered with the UMIN Clinical Trials Registry, UMIN000004179.
    Findings Between Nov 11, 2010, and July 3, 2014, we randomly assigned 25 patients to receive either thalidomide (n=13) or placebo (n=12); one patient in the placebo group was excluded from analyses because of a protocol violation. The adjusted mean VEGF concentration reduction rate at 24 weeks was 0.39 (SD 0.34) in the thalidomide group compared with -0.02 (0.54) in the placebo group (adjusted mean difference 0.41, 95% CI 0.02-0.80; p=0.04). Mild sinus bradycardia was more frequent in the thalidomide group than in the placebo group (seven [54%] vs zero; p=0.006). Five patients had serious adverse events: three in the thalidomide group (transient cardiac arrest, heart failure, and dehydration) and two in the placebo group (ileus and fever). No deaths occurred during the randomised study. In the 48-week open-label study period (n=22), newly developed adverse events were sinus bradycardia (n=4), constipation (n=5), and mild sensory neuropathy (n=5). Two patients died in the open-label study; both patients were initially in the placebo group, and the cause of death was progression of the disease.
    Interpretation Thalidomide reduces serum VEGF concentrations and represents a new treatment for patients with POEMS syndrome who are not eligible for stem-cell transplantation. Thalidomide treatment poses a risk of bradycardia; however, the benefits are likely to exceed the risk.

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  • Human neurexin-3 antibodies associate with encephalitis and alter synapse development Reviewed

    Nuria Gresa-Arribas, Jesus Planaguma, Mar Petit-Pedrol, Izumi Kawachi, Shinichi Katada, Carol A. Glaser, Mateus M. Simabukuro, Thais Armangue, Eugenia Martinez-Hernandez, Francesc Graus, Josep Dalmau

    NEUROLOGY   86 ( 24 )   2235 - 2242   2016.6

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    Objective:To report a novel autoimmune encephalitis in which the antibodies target neurexin-3, a cell adhesion molecule involved in the development and function of synapses.Methods:Five patients with encephalitis and antibodies with a similar pattern of brain reactivity were selected. Antigen precipitation and determination of antibody effects on cultured rat embryonic neurons were performed with reported techniques.Results:Immunoprecipitation and cell-based assays identified neurexin-3 as the autoantigen of patients' antibodies. All 5 patients (median age 44 years, range 23-50; 4 female) presented with prodromal fever, headache, or gastrointestinal symptoms, followed by confusion, seizures, and decreased level of consciousness. Two developed mild orofacial dyskinesias, 3 needed respiratory support, and 4 had findings suggesting propensity to autoimmunity. CSF was abnormal in all patients (4 pleocytosis, 1 elevated immunoglobulin G [IgG] index), and brain MRI was abnormal in 1 (increased fluid-attenuated inversion recovery/T2 in temporal lobes). All received steroids, 1 IV immunoglobulin, and 1 cyclophosphamide; 3 partially recovered, 1 died of sepsis while recovering, and 1 had a rapid progression to death. At autopsy, edema but no inflammatory cells were identified. Cultures of neurons exposed during days in vitro (div) 7-17 to patients' IgG showed a decrease of neurexin-3 clusters as well as the total number of synapses. No reduction of synapses occurred in mature neurons (div 18) exposed for 48 hours to patients' IgG. Neuronal survival, dendritic morphology, and spine density were unaffected.Conclusion:Neurexin-3 autoantibodies associate with a severe but potentially treatable encephalitis in which the antibodies cause a decrease of neurexin-3 and alter synapse development.

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  • Clinicopathological features in anterior visual pathway in neuromyelitis optica Reviewed

    Mariko Hokari, Akiko Yokoseki, Musashi Arakawa, Etsuji Saji, Kaori Yanagawa, Fumihiro Yanagimura, Yasuko Toyoshima, Kouichirou Okamoto, Satoshi Ueki, Tetsuhisa Hatase, Riuko Ohashi, Takeo Fukuchi, Kohei Akazawa, Mitsunori Yamada, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    ANNALS OF NEUROLOGY   79 ( 4 )   605 - 624   2016.4

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    ObjectiveNeuromyelitis optica spectrum disorder (NMOsd) is an autoimmune disorder of the central nervous system characterized by aquaporin-4 (AQP4) autoantibodies. The aim of this study was to elucidate the characteristics of involvement of the anterior visual pathway (AVP) and neurodegeneration via glia-neuron interaction in NMOsd.
    MethodsThirty Japanese patients with serologically verified NMOsd were assessed with a neuro-ophthalmological study. Using 27 tissue blocks from 13 other cases of NMOsd, we performed neuropathological analysis of glial and neuroaxonal involvement in the AVP.
    ResultsThe AVP involvement in NMOsd was characterized by the following, compared to multiple sclerosis: (1) longitudinally extensive optic neuritis (ON); (2) more severe visual impairment and worse prognosis for ON; (3) unique AQP4 dynamics, including loss of AQP4 immunoreactivity on astrocytes with complement activation in ON lesions, loss of AQP4 immunoreactivity on Muller cells with no deposition of complement in the retinas, and densely packed AQP4 immunoreactivity on astrocytes in gliosis of secondary anterograde/retrograde degeneration in the optic nerves and retinal nerve fiber layer (RNFL); and (4) more severe neurodegeneration, including axonal accumulation of degenerative mitochondria and transient receptor potential melastatin 4 channel with complement-dependent astrocyte pathology in ON lesions, mild loss of horizontal cells, and RNFL thinning and loss of ganglion cells with abundance of AQP4(+) astrocytes, indicating secondary retrograde degeneration after ON.
    InterpretationSevere and widespread neuroaxonal damage and unique dynamics of astrocytes/Muller cells with alterations of AQP4 were prominent in the AVP and may be associated with poor visual function and prognosis in NMOsd. Ann Neurol 2016;79:605-624

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  • Hypertrophic pachymeningitis: significance of myeloperoxidase anti-neutrophil cytoplasmic antibody Reviewed

    Akiko Yokoseki, Etsuji Saji, Musashi Arakawa, Takayuki Kosaka, Mariko Hokari, Yasuko Toyoshima, Kouichirou Okamoto, Shigeki Takeda, Kazuhiro Sanpei, Hirotoshi Kikuchi, Shunsei Hirohata, Kouhei Akazawa, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    BRAIN   137 ( Pt 2 )   520 - 536   2014.2

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    The aim of this study was to elucidate the characteristics, pathogenesis and treatment strategy of hypertrophic pachymeningitis that is associated with myeloperoxidase anti-neutrophil cytoplasmic antibody (ANCA). We retrospectively investigated clinical, radiological, immunological and pathological profiles of 36 patients with immune-mediated or idiopathic hypertrophic pachymeningitis, including 17 patients with myeloperoxidase-ANCA, four patients with proteinase 3-ANCA, six patients with other immune-mediated disorders, and nine patients with 'idiopathic' variety. Myeloperoxidase-ANCA-positive hypertrophic pachymeningitis was characterized by: (i) an elderly female predominance; (ii) 82% of patients diagnosed with granulomatosis with polyangiitis (previously known as Wegener's granulomatosis) according to Watts' algorithm; (iii) a high frequency of patients with lesions limited to the dura mater and upper airways, developing headaches, chronic sinusitis, otitis media or mastoiditis; (iv) a low frequency of patients with the 'classical or generalized form' of granulomatosis with polyangiitis involving the entire upper and lower airways and kidney, or progressing to generalized disease, in contrast to proteinase 3-ANCA-positive hypertrophic pachymeningitis; (v) less severe neurological damage according to the modified Rankin Scale and low disease activity according to the Birmingham Vasculitis Activity Score compared with proteinase 3-ANCA-positive hypertrophic pachymeningitis; (vi) increased levels of CXCL10, CXCL8 and interleukin 6 in cerebrospinal fluids, and increased numbers of T cells, neutrophils, eosinophils, plasma cells and monocytes/macrophages in autopsied or biopsied dura mater with pachymeningitis, suggesting T(H)1-predominant granulomatous lesions in hypertrophic pachymeningitis, as previously reported in pulmonary or renal lesions of granulomatosis with polyangiitis; and (vii) greater efficacy of combination therapy with prednisolone and cyclophosphamide compared with monotherapy with prednisolone. Proteinase 3-ANCA may be considered a marker for more severe neurological damage, higher disease activity and a higher frequency of the generalized form compared with myeloperoxidase-ANCA-positive hypertrophic pachymeningitis. However, categorization into 'granulomatosis with polyangiitis' according to Watts' algorithm and immunological or pathological features were common in both proteinase 3- and myeloperoxidase-ANCA-positive hypertrophic pachymeningitis. These data indicate that most patients with myeloperoxidase-ANCA-positive hypertrophic pachymeningitis should be categorized as having the central nervous system-limited form of ANCA-associated vasculitis, consistent with the concept of ophthalmic-, pulmonary- or renal-limited vasculitis.

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  • Late-onset anti-NMDA receptor encephalitis Reviewed

    Maarten J. Titulaer, Lindsey McCracken, Inigo Gabilondo, Takahiro Iizuka, Izumi Kawachi, L. Bataller, A. Torrents, Myrna R. Rosenfeld, Rita Balice-Gordon, Francesc Graus, Josep Dalmau

    NEUROLOGY   81 ( 12 )   1058 - 1063   2013.9

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    Objective: To describe the clinical features and outcome of anti-NMDA receptor (NMDAR) encephalitis in patients &gt;= 45 years old.
    Method: Observational cohort study.
    Results: In a cohort of 661 patients with anti-NMDAR encephalitis, we identified 31 patients &gt;= 45 years old. Compared with younger adults (18-44 years), older patients were more often male (45% vs 12%, p &lt; 0.0001), had lower frequency of tumors (23% vs 51%, p = 0.002; rarely teratomas), had longer median time to diagnosis (8 vs 4 weeks, p = 0.009) and treatment (7 vs 4 weeks, p = 0.039), and had less favorable outcome (modified Rankin Scale score 0-2 at 2 years, 60% vs 80%, p &lt; 0.026). In multivariable analysis, younger age (odds ratio [OR] 0.15, confidence interval [CI] 0.05-0.39, p = 0.0001), early treatment (OR 0.60, CI 0.47-0.78, p &lt; 0.0001), no need for intensive care (OR 0.09, CI 0.04-0.22, p &lt; 0.0001), and longer follow-up (p &lt; 0.0001) were associated with good outcome. Rituximab and cyclophosphamide were effective when first-line immunotherapies failed (OR 2.93, CI 1.10-7.76, p = 0.031). Overall, 60% of patients older than 45 years had full or substantial recovery at 24 months follow-up.
    Conclusions: Anti-NMDAR encephalitis is less severe in patients &gt;= 45 years old than in young adults, but the outcome is poorer in older patients. In this age group, delays in diagnosis and treatment are more frequent than in younger patients. The frequency of underlying tumors is low, but if present they are usually carcinomas instead of teratomas in younger patients. Early and aggressive immunotherapy will likely improve the clinical outcome.

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  • Relapse of multiple sclerosis in a patient retaining CCR7-expressing T cells in CSF under fingolimod therapy Reviewed

    Akiko Yokoseki, Etsuji Saji, Musashi Arakawa, Mariko Hokari, Takanobu Ishiguro, Fumihiro Yanagimura, Tomohiko Ishihara, Kouichirou Okamoto, Masatoyo Nishizawa, Izumi Kawachi

    MULTIPLE SCLEROSIS JOURNAL   19 ( 9 )   1230 - 1233   2013.8

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    Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor, and it traps lymphocytes in secondary lymphoid organs and precludes their migration into the central nervous system. We report the case of a patient who suffered a relatively severe relapse of multiple sclerosis (MS) during the initial 3 months of fingolimod therapy, with retention of CCR7 expression on CD4(+) T cells in the cerebrospinal fluid (CSF) despite decreased numbers of lymphocytes and decreased expression of CCR7 on CD4(+) T cells in the blood. These data suggest that fingolimod may cause differential effects on the CSF and blood lymphocytes of patients with MS during the initial months of therapy.

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  • Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study Reviewed

    Maarten J. Titulaer, Lindsey McCracken, Inigo Gabilondo, Thais Armangue, Carol Glaser, Takahiro Iizuka, Lawrence S. Honig, Susanne M. Benseler, Izumi Kawachi, Eugenia Martinez-Hernandez, Esther Aguilar, Nuria Gresa-Arribas, Nicole Ryan-Florance, Abiguei Torrents, Albert Saiz, Myrna R. Rosenfeld, Rita Balice-Gordon, Francesc Graus, Josep Dalmau

    LANCET NEUROLOGY   12 ( 2 )   157 - 165   2013.2

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    Background Anti-NMDA receptor (NMDAR) encephalitis is an autoimmune disorder in which the use of immunotherapy and the long-term outcome have not been defined. We aimed to assess the presentation of the disease, the spectrum of symptoms, immunotherapies used, timing of improvement, and long-term outcome.
    Methods In this multi-institutional observational study, we tested for the presence of NMDAR antibodies in serum or C SF samples of patients with encephalitis between Jan 1,2007, and Jan 1, 2012. All patients who tested positive for NMDAR antibodies were included in the study; patients were assessed at symptom onset and at months 4,8,12,18, and 24, by use of the modified Rankin scale (mRS). Treatment included first-line immunotherapy (steroids, intravenous immunoglobulin, plasmapheresis), second-line immunotherapy (ritincimab, cydophosphamide), and tumour removal. Predictors of outcome were determined at the Universities of Pennsylvania (PA, USA) and Barcelona (Spain) by use of a generalised linear mixed model with binary distribution.
    Results We enrolled 577 patients (median age 21 years, range 8 months to 85 years), 211 of whom were children (&lt;18 years). Treatment effects and outcome were assessable in 501 (median follow-up 24 months, range 4-186): 472 (94%) underwent first-line immunotherapy or tumour removal, resulting in improvement within 4 weeks in 251 (53%). Of 221 patients who did not improve with first-line treatment, 125 (57%) received second-line immunotherapy that resulted in a better outcome (mRS 0-2) than those who did not (odds ratio [OR] 2.69, CI 1-24-5.80; p=0.012). During the first 24 months, 394 of 501 patients achieved a good outcome (mRS 0-2; median 6 months, IQR 2-12) and 30 died. At 24 months' follow-up, 203 (81%) of 252 patients had good outcome. Outcomes continued to improve for up to 18 months after symptom onset. Predictors of good outcome were early treatment (0.62,0.50-0.76; p&lt;0.0001) and no admission to an intensive care unit (0.12,0.06-0-22; p&lt;0.0001). 45 patients had one or multiple relapses (representing a 12% risk within 2 years); 46 (67%) of 69 relapses were less severe than initial episodes (p&lt;0.0001). In 177 children, predictors of good outcome and the magnitude of effect of second-line immunotherapy were similar to those of the entire cohort.
    Interpretation Most patients with anti-NMDAR encephalitis respond to immunotherapy. Second-line immunotherapy is usually effective when first-line treatments fail. In this cohort, the recovery of some patients took up to 18 months.

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  • Cognitive Impairment and Cortical Degeneration in Neuromyelitis Optica Reviewed

    Etsuji Saji, Musashi Arakawa, Kaori Yanagawa, Yasuko Toyoshima, Akiko Yokoseki, Kouichirou Okamoto, Mika Otsuki, Kohei Akazawa, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    ANNALS OF NEUROLOGY   73 ( 1 )   65 - 76   2013.1

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    Objective: Neuromyelitis optica spectrum disorder (NMOsd) is an inflammatory and demyelinating syndrome characterized by optic neuritis and myelitis. Several magnetization transfer magnetic resonance imaging (MRI) studies have revealed abnormalities in normal-appearing gray matter in NMOsd. The aim of this study is to elucidate the characteristics and pathogenesis of cognitive impairment and neurodegeneration in NMOsd brains.
    Methods: Fourteen Japanese patients with serologically verified NMOsd, 17 patients with multiple sclerosis (MS), and 37 healthy controls were assessed with the Rao's Brief Repeatable Battery of Neuropsychological Tests (BRBN). Using 128 tissue blocks from 6 other cases of NMOsd, 3 cases of MS, and 4 controls without central nervous system involvement, we performed quantitative analysis of cortical neuronal loss and layer-specific changes in NMOsd.
    Results: In BRBN assessments, 57% of NMOsd patients and 47% of MS patients had impaired performance on at least 3 cognitive tests. Cognitive impairment in NMOsd was common even in the limited form of disease, indicating that NMOsd may progress insidiously from early stages of disease. Neuropathological assessments showed neuronal loss in cortical layers II, III, and IV, with nonlytic reaction of aquaporin-4 (AQP4)-negative astrocytes in layer I, massive activated microglia in layer II, and meningeal inflammation in NMOsd brains. All NMO cases showed no evidence of cortical demyelination.
    Interpretation: We demonstrate cognitive impairment and substantial cortical neuronal loss with unique AQP4 dynamics in astrocytes in NMOsd. These data indicate pathological processes consisting not only of inflammatory demyelinating events characterized by pattern-specific loss of AQP4 immunoreactivity but also cortical neurodegeneration in NMOsd brains. ANN NEUROL 2013;73:65-76

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  • A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans Reviewed

    Akiko Kitamura, Yoichi Maekawa, Hisanori Uehara, Keisuke Izumi, Izumi Kawachi, Masatoyo Nishizawa, Yasuko Toyoshima, Hitoshi Takahashi, Daron M. Standley, Keiji Tanaka, Jun Hamazaki, Shigeo Murata, Koji Obara, Itaru Toyoshima, Koji Yasutomo

    Journal of Clinical Investigation   121 ( 10 )   4150 - 4160   2011.10

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    Proteasomes are multisubunit proteases that play a critical role in maintaining cellular function through the selective degradation of ubiquitinated proteins. When 3 additional β subunits, expression of which is induced by IFN-γ, are substituted for their constitutively expressed counterparts, the structure is converted to an immunoproteasome. However, the underlying roles of immunoproteasomes in human diseases are poorly understood. Using exome analysis, we found a homozygous missense mutation (G197V) in immunoproteasome subunit, β type 8 (PSMB8), which encodes one of the β subunits induced by IFN-γ in patients from 2 consanguineous families. Patients bearing this mutation suffered from autoinflammatory responses that included recurrent fever and nodular erythema together with lipodystrophy. This mutation increased assembly intermediates of immunoproteasomes, resulting in decreased proteasome function and ubiquitin-coupled protein accumulation in the patient's tissues. In the patient's skin and B cells, IL-6 was highly expressed, and there was reduced expression of PSMB8. Downregulation of PSMB8 inhibited the differentiation of murine and human adipocytes in vitro, and injection of siRNA against Psmb8 in mouse skin reduced adipocyte tissue volume. These findings identify PSMB8 as an essential component and regulator not only of inflammation, but also of adipocyte differentiation, and indicate that immunoproteasomes have pleiotropic functions in maintaining the homeostasis of a variety of cell types.

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  • NO RELAPSE OF NEUROMYELITIS OPTICA DURING DRUG-INDUCED B-LYMPHOPENIA WITH HYPOGAMMAGLOBULINEMIA Reviewed

    Yuji Tanaka, Kiminori Kimura, Izumi Kawachi, Takashi Inuzuka

    NEUROLOGY   75 ( 19 )   1745 - 1747   2010.11

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  • Treatment responsive opsoclonus-ataxia associated with ovarian teratoma Reviewed

    I. Kawachi, E. Saji, Y. Toyoshima, J. Dalmau, M. Nishizawa

    Journal of Neurology, Neurosurgery and Psychiatry   81 ( 5 )   581 - 582   2010.5

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  • Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis Reviewed

    K. Yanagawa, I. Kawachi, Y. Toyoshima, A. Yokoseki, M. Arakawa, A. Hasegawa, T. Ito, N. Kojima, R. Koike, K. Tanaka, T. Kosaka, C. -F. Tan, A. Kakita, K. Okamoto, M. Tsujita, K. Sakimura, H. Takahashi, M. Nishizawa

    NEUROLOGY   73 ( 20 )   1628 - 1637   2009.11

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    Background: Neuromyelitis optica (NMO) is a demyelinating syndrome characterized by myelitis and optic neuritis. Detection of anti-NMO immunoglobulin G antibody that binds to aquaporin-4 (AQP4) water channels allows the diagnosis of a limited form of NMO in the early stage with myelitis, but not optic neuritis. However, the detailed clinicopathologic features and long-term course of this limited form remain elusive.
    Methods: We investigated 8 patients with the limited form of NMO with myelitis in comparison with 9 patients with the definite form.
    Result: All patients with limited and definite form showed uniform relapsing-remitting courses, with no secondary progressive courses. Pathologic findings of biopsy specimens from the limited form were identical to those of autopsy from the definite form, demonstrating extremely active demyelination of plaques, extensive loss of AQP4 immunoreactivity in plaques, and diffuse infiltration by macrophages containing myelin basic proteins with thickened hyalinized blood vessels. Moreover, the definite form at the nadir of relapses displayed significantly higher amounts of the inflammatory cytokines interleukin (IL)-1 beta and IL-6 in CSF than the limited form and multiple sclerosis.
    Conclusion: This consistency of pathologic findings and uniformity of courses indicates that aquaporin 4-specific autoantibodies as the initiator of the neuromyelitis optica (NMO) lesion consistently play an important common role in the pathogenicity through the entire course, consisting of both limited and definite forms, and NMO continuously displays homogeneity of pathogenic effector immune mechanisms through terminal stages, whereas multiple sclerosis should be recognized as the heterogeneous 2-stage disease that could switch from inflammatory to degenerative phase. This report is a significant description comparing the pathologic and immunologic data of limited NMO with those of definite NMO. Neurology (R) 2009; 73: 1628-1637

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  • Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology Reviewed

    Yasushi Nishihira, Chun-Feng Tan, Yasuhiro Hoshi, Keisuke Iwanaga, Megumi Yamada, Izumi Kawachi, Mitsuhiro Tsujihata, Isao Hozumi, Takashi Morita, Osamu Onodera, Masatoyo Nishizawa, Akiyoshi Kakita, Hitoshi Takahashi

    ACTA NEUROPATHOLOGICA   117 ( 1 )   45 - 53   2009.1

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    Recently, sporadic amyotrophic lateral sclerosis (SALS), a fatal neurological disease, has been shown to be a multisystem proteinopathy of TDP-43 in which both neurons and glial cells in the central nervous system are widely affected. In general, the natural history of SALS is short (&lt; 5 years). However, it is also known that a few patients may survive for 10 years or more, even without artificial respiratory support (ARS). In the present study using TDP-43 immunohistochemistry, we examined various regions of the nervous system in six patients with SALS of long duration (10-20 years) without ARS, in whom lower motor-predominant disease with Bunina bodies and ubiquitinated inclusions (UIs) in the affected lower motor neurons was confirmed. One case also showed UIs in the hippocampal dentate granule cells (UDG). In all cases, except one with UDG, the occurrence of TDP-43-immunoreactive (ir) neuronal cytoplasmic inclusions (NCIs) was confined to a few regions in the spinal cord and brainstem, including the anterior horns. In one case with UDG, TDP-43-ir NCIs were also detected in the substantia nigra, and some regions of the cerebrum, including the hippocampal dentate gyrus (granule cells). The number of neurons displaying NCIs in each region was very small (1-3 per region, except the dentate gyrus). On the other hand, the occurrence of TDP-43-ir glial cytoplasmic inclusions (GCIs) was more widespread in the central nervous system, including the cerebral white matter. Again, however, the number of glial cells displaying GCIs in each region was very small (1-3 per region). In conclusion, compared to the usual form of SALS, TDP-43 pathology shown in SALS of long duration was apparently mild in degree and limited in distribution, corresponding to the relatively benign clinical courses observed. It is now apparent that SALS of long duration is actually part of a TDP-43 proteinopathy spectrum.

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  • Novel locus for benign hereditary chorea with adult onset maps to chromosome 8q21.3-q23.3 Reviewed

    Takayoshi Shimohata, Kenju Hara, Kazuhiro Sanpei, Jin-ichi Nunomura, Tetsuya Maeda, Izumi Kawachi, Masato Kanazawa, Kensaku Kasuga, Akinori Miyashita, Ryozo Kuwano, Koichi Hirota, Shoji Tsuji, Osamu Onodera, Masatoyo Nishizawa, Yoshiaki Honma

    BRAIN   130 ( Pt 9 )   2302 - 2309   2007.9

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    Autosomal dominant choreas are genetically heterogeneous disorders including Huntington disease (HD), Huntington disease like 1 (HDL1), Huntington disease like 2 (HDL2), dentatorubro-pallidoluysian atrophy ( DRPLA), spinocerebellar ataxia type 17 (SCA17) and benign hereditary chorea (BHC). We identified two Japanese families with adult-onset benign chorea without dementia inherited in an autosomal dominant pattern. All affected individuals presented slowly progressive choreic movements in their upper and lower extremities, trunk and head with an age of onset ranging from 40 to 66 ( average 54.3), which were markedly improved by haloperidol. The affected individuals also developed reduced muscle tones in their extremities. The findings obtained in the brain CT or MRI studies of nine affected individuals were normal. These clinical features resemble those of the so-called 'senile chorea'. HD, HDL1, HDL2, DRPLA, SCA17 and BHC caused by mutations in the TITF-1 gene were excluded by mutational and linkage analyses. A genome-wide linkage analysis revealed linkage to chromosome 8q21.3-q23.3 with a maximum cumulative two-point log of the odds (LOD) score of 4.74 at D8S1784 (theta = 0.00). Haplotype analysis of both the families defined the candidate region as 21.5Mb interval flanked by M9267 and D8S1139. We named this adult- onset dominant inherited chorea 'benign hereditary chorea type 2 (BHC2)'.

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  • MR1-restricted V alpha 19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response Reviewed

    Kawachi, I, J Maldonado, C Strader, S Gilfillan

    JOURNAL OF IMMUNOLOGY   176 ( 3 )   1618 - 1627   2006.2

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    Mucosal-associated invariant T (MAIT) cells reside primarily in the gut lamina propria and require commensal flora for selection/expansion. They are restricted by the highly conserved MHC class I-related molecule MR1 and, like most NK T cells, express an invariant TCR alpha chain. Although they probably contribute to gut immunity, MAIT cells have not been functionally characterized because they are so rare. To create a model in which they are more abundant, we generated transgenic mice expressing only the TCRa chain (V alpha 19i) that defines MAIT cells. By directly comparing V alpha 19i transgenic mice on MRI(+/+) and MRI(-/-) backgrounds, we were able to distinguish and characterize a population of V alpha 19i T cells dependent on MR1 for development. MR1-restricted V alpha 19i transgenic T cells recapitulate what is known about MAIT cell development. Furthermore, a relatively high proportion of transgenic MAIT cells express NK1.1, and most have a cell surface phenotype similar to that of V alpha 14i NK T cells. Finally, MR1-restricted V alpha 19i T cells secrete IFN-gamma, IL-4, IL-5, and IL-10 following TCR ligation, and we provide evidence for what may be two functionally distinct MAIT cell populations. These data strongly support the idea that MAIT cells contribute to the innate immune response in the gut mucosa.

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  • Japanese cases of familial hemiplegic migraine with cerebellar ataxia carrying a T666M mutation in the CACNA1A gene Reviewed

    T Takahashi, S Igarashi, T Kimura, Hozumi, I, Kawachi, I, O Onodera, H Takano, M Saito, S Tsuji

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   72 ( 5 )   676 - 677   2002.5

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  • Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene Reviewed

    H Date, O Onodera, H Tanaka, K Iwabuchi, K Uekawa, S Igarashi, R Koike, T Hiroi, T Yuasa, Y Awaya, T Sakai, T Takahashi, H Nagatomo, Y Sekijima, Kawachi, I, Y Takiyama, M Nishizawa, N Fukuhara, K Saito, S Sugano, S Tsuji

    NATURE GENETICS   29 ( 2 )   184 - 188   2001.10

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    Friedreich ataxia (FRDA), the most common autosomal recessive neurodegenerative disease among Europeans and people of European descent, is characterized by an early onset (usually before the age of 25), progressive ataxia, sensory loss, absence of tendon reflexes and pyramidal weakness of the legs(1-4). We have recently identified a unique group of patients whose clinical presentations are characterized by autosomal recessive inheritance, early age of onset, FRDA-like clinical presentations and hypoalbuminemia. Linkage to the FRDA locus, however, was excluded. Given the similarities of the clinical presentations to those of the recently described ataxia with oculomotor apraxia (AOA) linked to chromosome 9p13, we confirmed that the disorder of our patients is also linked to the same locus(5). We narrowed the candidate region and have identified a new gene encoding a member of the histidine triad (HIT) superfamily as the 'causative' gene. We have called its product aprataxin; the gene symbol is APTX. Although many HIT proteins have been identified, aprataxin is the first to be linked to a distinct phenotype.

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  • Dendritic cells presenting pyruvate kinase M1/M2 isozyme peptide can induce experimental allergic myositis in BALB/c mice Reviewed

    Kawachi, I, K Tanaka, M Tanaka, S Tsuji

    JOURNAL OF NEUROIMMUNOLOGY   117 ( 1-2 )   108 - 115   2001.7

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    Polymyositis (PM) is an inflammatory muscle disease caused by autoimmune dysfunction, considered to be caused by cytotoxic CD8 T cells. To date, no autoantigens have been identified. We attempted to induce an experimental allergic myositis (EAM) in BALB/c mice by inoculating syngeneic dendritic cells (DC) presenting peptides that are expected to match the binding anchor motif of H-2K(d) (BALB/c). We selected peptides that are highly expressed in skeletal muscle. Only when we inoculated syngeneic bone marrow-derived DC presenting pyruvate kinase M1/M2 peptide 464-472 in BALB/c mice, 41.7% of the mice (EAM) developed pathological changes in skeletal muscle compatible to human PM. Under other conditions (when we inoculated DC presenting no synthetic peptides into BALB/c or C57BL/6 mice and DC presenting pyruvate kinase M1/M2 peptide into C57BL/6 mice), there were no necrotizing and inflammatory lesions. Induction of EAM in the same manner as above also induced CTL activity against P815 cells with the same peptide and syngeneic differentiated cultured myotubes without peptides by the chromium release assay. Consistent with the similarity of the binding anchor motif of H-2Kd (BALB/c) and HLA A* 2402, we conclude that pyruvate kinase M1/M2 peptide is a candidate autoantigen not only in BALB/c-EAM but also in human-PM with the HLA A* 2402 allele. (C) 2001 Elsevier Science B.V, All rights reserved.

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  • Spontaneous spinal cord herniation Reviewed

    Kawachi, I, H Nozaki, M Watanabe, A Sato, S Tsuji

    NEUROLOGY   56 ( 7 )   977 - 977   2001.4

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  • A Comparative Study of Face-to-Face and Online Interprofessional Education Models for Nursing Students in Japan: A Cross-Sectional Survey Reviewed

    Aya Saitoh, Tomoe Yokono, Tomoko Sumiyoshi, Izumi Kawachi, Mieko Uchiyama

    Education Sciences   13 ( 9 )   937 - 937   2023.9

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    This study investigated the effects of an online interprofessional education (IPE) program on nursing students at a university in Japan. It conducted a comparative analysis between traditional face-to-face and online interventions. All students who enrolled in the “Team Medical Practice” course in both 2019 and 2020 were invited to participate. After team-based learning with different healthcare professions, we quantitatively analyzed pre- and post-intervention outcomes using two measures: the Readiness for Interprofessional Learning Scale (RIPLS) and the IPE Questionnaire TSUKUBA model (IPET). We compared the results of 153 nursing students. The RIPLS results demonstrate significant pre- and post-intervention score differences in the teamwork and collaboration subscale for the online group only. The post-IPE score analysis revealed that scores were significantly higher in the online group in all subscales: Teamwork and collaboration, Opportunities for IPE, and Uniqueness of profession. Based on the IPET results, there were no significant differences in pre- and post-intervention scores. However, the online group showed a significant increase in post-intervention scores in participation in group work, thoughts about the team in health and welfare, and thoughts about interprofessional collaboration. These findings indicate that the online IPE program improved nursing students’ readiness for interprofessional learning, demonstrating practical efficacy.

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  • MS2 第5回全国調査からみる多発性硬化症の二次性進行型に移行するリスク因子の検討

    渡邉 充, 磯部 紀子, 新野 正明, 中島 一郎, 松下 拓也, 酒井 康成, 中原 仁, 河内 泉, 越智 博文, 中辻 裕司, 中村 好一, 中村 幸志, 坂田 清美, 松井 真, 桑原 聡, 吉良 潤一

    神経免疫学   27 ( 1 )   159 - 159   2022.10

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  • 連載 脳神経内科領域における医学教育の展望—Post/withコロナ時代を見据えて・12 オンライン多職種連携教育 Invited

    河内泉

    Brain and nerve   74 ( 8 )   1031 - 1036   2022.8

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    DOI: 10.11477/mf.1416202174

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  • Progressive micrographia without parkinsonism caused by autoimmune brainstem encephalitis: A case report. Reviewed International journal

    Ryutaro Hanyu, Masahiro Hatakeyama, Masaki Namekawa, Yutaka Otsu, Mayura Sukegawa, Hiromi Hashida, Izumi Kawachi, Masato Kanazawa, Osamu Onodera

    Clinical neurology and neurosurgery   202   106496 - 106496   2021.3

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  • IgG4-related Disease of the Nervous Systems Invited

    Akihiro Nakajima, Izumi Kawachi

    Brain Nerve   73 ( 5 )   584 - 594   2021

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    DOI: 10.11477/mf.1416201802.

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  • Tumefactive demyelinating lesion (TDL). 脳神経画像Critical Findings おさえておきたい症状とCT/MRI画像所見 Invited

    中島章博, 河内泉

    脳神経外科   49 ( 2 )   376 - 382   2021

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  • Learning outcomes of interprofessional collaboration among medical and nursing students in Japan Reviewed

    Tomoko Sumiyoshi, Tomoe Yokono, Izumi Kawachi, Toshiya Suzuki

    Journal of Interprofessional Education &amp; Practice   21   100377 - 100377   2020.12

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  • [A case of thyrotoxic myopathy with generalized body muscular atrophy including the tongue muscle, lacking physical manifestations of Basedow disease].

    Sho Kitahara, Takahumi Tonouchi, Yutaka Otsu, Izumi Kawachi, Mutsuo Oyake, Nobuya Fujita

    Rinsho shinkeigaku = Clinical neurology   60 ( 10 )   677 - 681   2020.10

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    We report a 74-year-old man with a 2-year history of proximal limb pain, body weight loss of 15 kg, and muscle weakness. Muscle atrophy was evident in the limbs and trunk, as well as the tongue. He was admitted to our hospital with suspected amyotrophic lateral sclerosis (ALS). Although he had no physical manifestations of Basedow disease such as palpitations, hyperhidrosis, hand tremor, exophthalmos, and an enlarged thyroid, he was diagnosed as having thyrotoxic myopathy as laboratory examinations indicated hyperthyroidism and positivity for TSH receptor antibody. The serum level of soluble IL-2 receptor was also elevated. Despite the severe muscle atrophy, the serum CK level was normal. A biopsy from the left quadriceps muscle revealed Type 1 fibers atrophy. Administration of anti-thyroid drugs normalized his thyroid function and the level of soluble IL-2 receptor, leading to improvement of the generalized muscle atrophy.

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  • Recommendations for the Management of Neuro-Behçet's Disease by the Japanese National Research Committee for Behçet's Disease. Reviewed

    Shunsei Hirohata, Hirotoshi Kikuchi, Tetsuji Sawada, Masato Okada, Mitsuhiro Takeno, Masataka Kuwana, Izumi Kawachi, Hideki Mochizuki, Susumu Kusunoki, Yoshiaki Ishigatsubo

    Internal medicine (Tokyo, Japan)   59 ( 19 )   2359 - 2367   2020.10

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    Objective Brain parenchymal involvement in Behçet's disease (BD) (neuro-Behçet's disease, NB) can be classified into acute type (ANB) and chronic progressive type (CPNB) based on differences in the clinical course and responses to corticosteroid treatment. The present study developed evidence-based recommendations for the management of NB.Methods The task force of the research subcommittee consisted of seven board-certified rheumatologists (one was also a board-certified neurologist) and three board-certified neurologists. First, several clinical questions (CQs) were established. A systematic literature search was performed by The Japan Medical Library Association in order to develop recommendations. The final recommendations for each CQ developed from three blind Delphi rounds, for which the rate of agreement scores [range 1 (strongly disagree)-5(strongly agree)] was determined through voting by the task force.Results A flow chart of the algorithm was established for the management of ANB and CPNB. Thirteen recommendations were developed for NB (general 1, ANB 7, CPNB 5). The strength of each recommendation was established based on the evidence level as well as the rate of agreement.Conclusion The recommendations generated in this study are based on the results of uncontrolled evidence from open trials, retrospective cohort studies and expert opinions, due to the lack of randomized clinical trials. Nevertheless, these recommendations can be used for international studies, although verification by further properly designed controlled clinical trials is required.

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  • 新潟大学におけるCOVID-19パンデミック下のオンライン医学教育―未来教育への道すじ―

    河内 泉, 須貝 拓朗, 鈴木 利哉, 土田 正則, 齋藤 昭彦, 佐藤 昇, 染矢 俊幸

    医学教育   51 ( 3 )   231 - 233   2020.6

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  • Neuromyelitis optica spectrum disorder with massive basal ganglia involvement: a case report Reviewed

    Shinji Ohara, Taka-aki Miyahira, Kenya Oguchi, Yo-ichi Takei, Fumihiro Yanagimura, Izumi Kawachi, Kiyomitsu Oyanagi, Akiyoshi Kakita

    BMC Neurology   19 ( 1 )   351   2019.12

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    Abstract

    Background

    Occurrence of basal ganglia involvement in neuromyelitis optica spectrum disorders (NMOSD) has rarely been reported and none documented pathologically.

    Case presentation

    A 73-year-old female was clinically diagnosed with a NMOSD based on the clinical and radiological features and positive serum autoantibodies to AQP4. One month before her death, she became acutely ill with disturbed consciousness and right hemiparesis, and was diagnosed and treated as having basal ganglia infarction based on the brain CT. She made a partial recovery but later died from heart failure. At autopsy, the corresponding basal ganglia process revealed a large fresh area of necrosis. Histologically, several pathological signatures of NMOSD could be recognized in the lesion, including inflammatory cell infiltrations by B and T lymphocytes, perivascular complement and fibrinogen deposition, and the appearance of numerous phagocytosed corpora amylacea within the infiltrating macrophages.

    Conclusions

    The present case illustrates that basal ganglia may be directly involved in the pathological processes of NMOSD, although the possibility of modification of the lesions by superimposed regional ischemia could not be excluded.

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    Other Link: http://link.springer.com/article/10.1186/s12883-019-1580-3/fulltext.html

  • [A case of anti-titin antibody positive nivolumab-related necrotizing myopathy with myasthenia gravis]. Reviewed

    Isami A, Uchiyama A, Shimaoka Y, Suzuki S, Kawachi I, Fujita N

    Rinsho shinkeigaku = Clinical neurology   59 ( 7 )   431 - 435   2019.7

  • An autopsy case of peliosis hepatis with X-linked myotubular myopathy. Reviewed International journal

    Kazuhisa Funayama, Hiroshi Shimizu, Hidetomo Tanaka, Izumi Kawachi, Ichizo Nishino, Kou Matsui, Naoya Takahashi, Akihide Koyama, Rieka Katsuragi-Go, Ryoko Higuchi, Takashi Aoyama, Hiraku Watanabe, Akiyoshi Kakita, Hisakazu Takatsuka

    Legal medicine (Tokyo, Japan)   38   77 - 82   2019.5

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    This report describes the autopsy case of a 4-year-old boy who died from hepatic hemorrhage and rupture caused by peliosis hepatis with X-linked myotubular myopathy. Peliosis hepatis is characterized by multiple blood-filled cavities of various sizes in the liver, which occurs in chronic wasting disease or with the use of specific drugs. X-linked myotubular myopathy is one of the most serious types of congenital myopathies, in which an affected male infant typically presents with severe hypotonia and respiratory distress immediately after birth. Although each disorder is rare, 12 cases of pediatric peliosis hepatis associated with X-linked myotubular myopathy have been reported, including our case. Peliosis hepatis should be considered as a cause of hepatic hemorrhage despite its low incidence, and it requires adequate gross and histological investigation for correct diagnosis.

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  • Treatment and comorbidities of multiple sclerosis in an employed population in Japan: analysis of health claims data. Reviewed

    Ogino M, Shiozawa A, Ota H, Okamoto S, Hiroi S, Kawachi I

    Neurodegenerative disease management   8 ( 2 )   97 - 103   2018.4

  • [Autoantibodies in Paraneoplastic Neurological Syndrome]. Invited

    Kawachi I

    Brain and nerve = Shinkei kenkyu no shinpo   70 ( 4 )   329 - 339   2018.4

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  • Prevalence, treatments and medical cost of multiple sclerosis in Japan based on analysis of a health insurance claims database Reviewed

    Mieko Ogino, Shuichi Okamoto, Hiroyuki Ohta, Mariko Sakamoto, Yusuke Nakamura, Kosuke Iwasaki, Manami Yoshida, Shinzo Hiroi, Izumi Kawachi

    Clinical and Experimental Neuroimmunology   8 ( 4 )   318 - 326   2017.11

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    Objective: To understand, through an analysis of health insurance claims data, the current treatment status and medical cost of multiple sclerosis (MS) in Japan. Methods: We analyzed claims data (January 2005–January 2016) from the Japan Medical Data Center Co., Ltd., identifying MS patients, except those with neuromyelitis optica, using an algorithm based on diagnosis codes. Prescription drug usage and medical costs for MS patients were analyzed. Results: A total of 713 MS patients were identified in the database. Between 2011 and 2015, the age-adjusted prevalence of MS in the database increased from 0.015% to 0.019%, and the female-to-male ratio increased from 1.70 to 2.03. The prescription rate for disease-modifying therapy drugs was higher in larger care settings. Prescriptions for fingolimod increased from 2011, with a concomitant decrease in prescriptions for interferon. The per patient per month cost for MS was \124 337 (US$1190 or €1084, as of October 2016). This was higher than the costs for Parkinson's disease (\84 410), myasthenia gravis (\82 944) and rheumatoid arthritis (\53 843). However, the total per member per month cost for MS, which represents the population-based economic impact, was \25.2, which was lower than the parallel costs for Parkinson's disease (\123.0) and rheumatoid arthritis (\311.6) because of the low prevalence of MS in Japan. Conclusions: Using real-world data, we obtained up-to-date prevalence, treatment status and medical cost information for MS in Japan. The present results showed the efficacy of a real-world database to obtain the latest national trends for rare diseases, such as MS
    this could have important implications for clinicians and policymakers.

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  • Efficacy of delayed-release dimethyl fumarate in Japanese patients with relapsing multiple sclerosis in the placebo-controlled phase 3 apex study Reviewed

    T. Kondo, I. Kawachi, Y. Onizuka, K. Hiramatsu, M. Hase, J. Yun, Y. Ling, S. Torii

    Journal of the Neurological Sciences   381   439 - 440   2017.10

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  • Efficacy of intravenous methylprednisolone pulse therapy in patients with multiple sclerosis and neuromyelitis optica Reviewed

    Ryo Yamasaki, Takuya Matsushita, Toshiyuki Fukazawa, Kazumasa Yokoyama, Kazuo Fujihara, Mieko Ogino, Takanori Yokota, Katsuichi Miyamoto, Masaaki Niino, Kyoichi Nomura, Ryo Tomioka, Masami Tanaka, Izumi Kawachi, Takashi Ohashi, Ken-ichi Kaida, Makoto Matsui, Yuji Nakatsuji, Hirofumi Ochi, Hikoaki Fukaura, Takashi Kanda, Akiko Nagaishi, Kanae Togo, Hidehiro Mizusawa, Hiroyuki Murai, Jun-ichi Kira

    MULTIPLE SCLEROSIS JOURNAL   22 ( 10 )   1337 - 1348   2016.9

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    Background: No large-scale studies have compared the efficacy of intravenous methylprednisolone pulse therapy (IVMP) for multiple sclerosis (MS) and neuromyelitis optica (NMO).
    Objective: To explain differences in treatment responses of MS and NMO patients to IVMP.
    Methods: Changes in neurological symptoms/signs and Expanded Disability Status Scale (EDSS) scores before and within 1week of IVMP completion were obtained in 2010 at 28 institutions, and retrospectively collated from 271 MS (478 courses) and 73 NMO (118 courses) cases.
    Results: In MS patients, decreased EDSS score was significant after the first (-0.80.9), second (-0.7 +/- 0.9), and third (-0.7 +/- 0.8) courses (p&lt;0.05), but not after the fourth (-0.3 +/- 0.7) and fifth (-0.5 +/- 0.6). However, decreased EDSS score was only significant after the first course (-0.5 +/- 1.5, p&lt;0.05) in NMO patients. EDSS score was significantly decreased in MS compared with NMO patients at the first course (p&lt;0.05), but not thereafter. Model analysis for EDSS score improvement at the first course, adjusting for covariates, showed significantly greater decreases in MS compared with NMO patients (p&lt;0.05).
    Conclusion: IVMP is effective in MS from the first to third courses, and in NMO at the first course. Additionally, IVMP is more efficacious in MS than NMO patients, even at the first course.

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  • Pathomechanism of severe visual impairment in neuromyelitis optica Invited Reviewed

    Izumi Kawachi, Mariko Hokari, Masatoyo Nishizawa

    Clinical and Experimental Neuroimmunology   7 ( 3 )   213 - 214   2016.8

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  • Current treatment status and medical cost for multiple sclerosis based on analysis of a Japanese claims database Reviewed

    Mieko Ogino, Izumi Kawachi, Kazuyoshi Otake, Hiroyuki Ohta, Yujiro Otsuka, Kosuke Iwasaki, Shinzo Hiroi

    Clinical and Experimental Neuroimmunology   7 ( 2 )   158 - 167   2016.5

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    Objective To assist policymakers as they reflect on treatment protocols and approaches for the efficient delivery of medical care for multiple sclerosis (MS) patients in Japan. Methods We analyzed data from a large Japanese health insurance claims database. Using an algorithm based on diagnosis codes, all patients with a diagnosis of MS were identified
    patients having a non-MS demyelinating disease were excluded from the population. MS patient data were used for cross-sectional analysis carried out on the data collected at a certain period. We identified a total of 1808 MS patients, and we analyzed data for 1133 patients with an observation period of ≥6 months from October 2013 to September 2014. Newly diagnosed MS patients were identified within the MS patients, and their data were used for longitudinal analysis, tracking each patient over a period of time. Results The total per patient per month cost for MS was \ 93 542 (US$781, €695 as of October 2015). Disease-modifying therapy drugs costs constituted half of the overall medical costs. For newly diagnosed MS patients, hospitalization costs were the largest component in the initial month, while drug costs were the largest component more than several months after the initial visit. There was a positive correlation between relapse frequency and medical cost. Conclusions These results provide up-to-date information on the demographics, medical treatment and cost status of MS in almost real-time by using a claims database. They suggest that claims data analysis can effectively support medical policymaking.

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  • A case of slowly progressive anti-Yo-associated paraneoplastic cerebellar degeneration successfully treated with antitumor and immunotherapy. Reviewed

    Tsuboguchi S, Yajima R, Higuchi Y, Ishikawa M, Kawachi I, Koyama Y, Nishizawa M

    Rinsho Shinkeigaku.   48 ( (4) )   1119 - 1122   2016.5

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  • Fibromyalgia in a Patient with Cushing's Disease Accompanied by Central Hypothyroidism Reviewed

    Nobumasa Ohara, Shinichi Katada, Takaho Yamada, Naomi Mezaki, Hiroshi Suzuki, Akiko Suzuki, Osamu Hanyu, Yuichiro Yoneoka, Izumi Kawachi, Takayoshi Shimohata, Akiyoshi Kakita, Masatoyo Nishizawa, Hirohito Sone

    INTERNAL MEDICINE   55 ( 21 )   3185 - 3190   2016

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    A 39-year-old woman with a 3-year history of a rounded face developed widespread myalgia. Detailed examinations revealed no disorders that could explain the pain other than concomitant Cushing's disease and central hypothyroidism. Both the hypercortisolemia and hypothyroidism completely resolved after the patient underwent surgery to treat Cushing's disease, but she continued to experience unresolved myalgia and met the diagnostic criteria for fibromyalgia. Few studies have so far investigated patients with fibromyalgia associated with Cushing's syndrome. In our case, the hypothyroidism caused by Cushing's disease probably played an important role in triggering and exacerbating fibromyalgia. This highlights the need to examine the endocrine function in patients with muscle pain.

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  • A case of slowly progressive anti-Yo-associated paraneoplastic cerebellar degeneration successfully treated with antitumor and immunotherapy Reviewed

    Shintaro Tsuboguchi, Ryuji Yajima, You Higuchi, Masanori Ishikawa, Izumi Kawachi, Yu Koyama, Masatoyo Nishizawa

    Clinical Neurology   56 ( 7 )   477 - 480   2016

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    We report a case of slowly progressive anti-Yo-associated paraneoplastic cerebellar degeneration (PCD) with breast cancer in a 54-year-old woman. The symptoms of limb and truncal ataxia, and dysarthria gradually progressed during the course of 1 year, and the modified Rankin scale (mRS) score was 2. A mastectomy with sentinel lymph node resection was performed for the breast cancer. No malignant cells were found on histopathological examination of the lymph node. Combination chemotherapy with adriamycin and cyclophosphamide (AC) prevented neurologic deterioration. However, subsequent treatment with trastuzumab and paclitaxel did not prevent progression of the symptoms (mRS score 3). Brain magnetic resonance imaging showed atrophy of the cerebellar hemispheres without brain stem atrophy. Anti-Yo antibody was detected in the serum, which led to a diagnosis of anti-Yo-associated PCD. We resected an enlarged axillary lymph node, which was found on computed tomography. The histopathological analysis of the lymph node revealed foreign body granuloma, which suggested an association with necrotic malignant tissue. Following additional tegafur-uracil therapy and two courses of intravenous immunoglobulin (IVIg), the cerebellar signs and symptoms gradually improved (mRS score 2). The clinical course shows that PCD can present as a slowly progressive cerebellar symptom. We propose an active treatment for anti-Yo-associated PCD consisting of tumor resection, combined chemotherapy, and IVIg.

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  • A fulminant case of granulomatosis with polyangiitis with meningeal and parenchymal involvement Reviewed

    Ryuji Yajima, Yasuko Toyoshima, Yoko Wada, Tetsuya Takahashi, Hiroyuki Arakawa, Gaku Ito, Daisuke Kobayashi, Mitsunori Yamada, Izumi Kawachi, Ichiei Narita, Hitoshi Takahashi, Masatoyo Nishizawa

    Case Reports in Neurology   7 ( 1 )   101 - 104   2015.5

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    Central nervous system (CNS) involvement, such as pachymeningitis and/or cerebrovascular events, is rare in patients with granulomatosis with polyangiitis (GPA). Furthermore, the details of pathological examinations of cases have rarely been described. We describe a case of GPA that manifested as an isolated paranasal sinus disease that invaded the subarachnoid space and caused a hemorrhagic venous infarction. We also describe the pathological characteristics of the biopsied brain material from the successful decompressive craniectomy. In particular, granulomatous inflammation with geographic necrosis and multinucleated giant cells were observed in the perivascular area of the thickened dura mater and leptomeninges. Small vessels in the meninges were involved in the granulomatous lesions, and the lumens of the veins were often occluded. In the cerebral cortices and white matter in these areas, hemorrhagic infarction was widely observed. We suggest that our findings represent a novel mechanism of CNS involvement in GPA. Moreover, we believe that the emergency decompressive craniectomy and partial lobectomy for the cerebral infarction in this patient with GPA likely contributed to his survival.

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  • Cortical gray matter lesions in multiple sclerosis Invited

    Izumi Kawachi, Masatoyo Nishizawa

    Brain and Nerve   67 ( 4 )   497 - 504   2015.4

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    Multiple sclerosis (MS) and neuromyelitis optica (NMO) are the two main autoimmune and inflammatory diseases of the central nervous system. MS is considered an 'oligodendrocytopathy' with undefined autoantibodies, whereas NMO is considered an 'astrocytopathy' with aquaporin-4 antibodies. Both have long been considered autoimmune diseases that primarily affect the white matter (WM). However, recent interest in gray matter (GM) pathology is emerging. Pathological evaluations reveal that substantial cortical demyelination is prominent at all stages or courses of MS. In addition, the neurodegeneration in MS is present not only in GM demyelination but also in normal-appearing GM. NMO involves cortical neurodegeneration and unique dynamics of astrocytes
    however, no cortical demyelination is seen. Thus, MS and NMO are distinct diseases with unique pathological features in the brain WM and GM. Although the cause of GM and WM lesions in MS and NMO has not been fully determined, improved knowledge about the pathomechanisms in affected brains is desired. This would result in a more targeted pharmacotherapeutic approach to these diseases.

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  • Effect of sodium pyruvate on exercise intolerance and muscle weakness due to mitochondrial myopathy: A case report Reviewed

    Yasuko Kuroha, Mari Tada, Izumi Kawachi, Masatoyo Nishizawa, Nae Matsubara, Ryoko Koike

    Clinical Neurology   55 ( 6 )   412 - 416   2015

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    We report the case of a 19-year-old woman who had been suffering from general fatigue and exercise intolerance since 15 years old. At 18 years old, she experienced muscle weakness and myalgia of the calves. Six months later, she was admitted to our hospital. She showed muscle weakness of the neck and proximal limbs, and myalgia of the calves was prominent. Serum levels of creatine kinase (CK) and lactic acid were elevated, as was the level of lactic acid in cerebrospinal fluid. T2-weighted and short-inversion-time inversion recovery (STIR) imaging of the lower limbs showed hyperintensity on bilateral gastrocnemius muscles, and the region revealed Gd enhancement. Based on histopathological findings from muscle and identification of a m.3271T&gt
    C point mutation, mitochondrial myopathy was diagnosed. Rest and administration of vitamins B1, and B2, coenzyme Q10, and L-carnitine improved serum CK levels
    however, exercise intolerance, myalgia, and lactic acidemia remained. Sodium pyruvate was then administered, and lactic acid levels, exercise intolerance, and findings on magnetic resonance imaging improved. Sodium pyruvate could prove effective in addressing both elevated serum lactic acid levels and exercise intolerance in mitochondrial disease.

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  • Varicella-zoster virus encephalitis localized to the bilateral medial temporal lobes Reviewed

    Ryuji Yajima, Kota Utsumi, Tomohiko Ishihara, Masato Kanazawa, Kouichirou Okamoto, Izumi Kawachi, Masatoyo Nishizawa

    Neurology: Neuroimmunology and NeuroInflammation   2 ( 4 )   e108   2015

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  • Japanese POEMS syndrome with Thalidomide (J-POST) Trial: study protocol for a phase II/III multicentre, randomised, double-blind, placebo-controlled trial Reviewed

    Kanako Katayama, Sonoko Misawa, Yasunori Sato, Gen Sobue, Ichiro Yabe, Osamu Watanabe, Masatoyo Nishizawa, Susumu Kusunoki, Seiji Kikuchi, Ichiro Nakashima, Shu-ichi Ikeda, Nobuo Kohara, Takashi Kanda, Jun-ichi Kira, Hideki Hanaoka, Satoshi Kuwabara

    BMJ OPEN   5 ( 1 )   e007330   2015

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    Introduction: Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome is a fatal systemic disorder associated with plasma cell dyscrasia and the overproduction of the vascular endothelial growth factor (VEGF). Recently, the prognosis of POEMS was substantially improved by introduction of therapeutic intervention for myeloma. However, no randomised clinical trial has been performed because of the rarity and severity of the disease.
    Methods and analysis: The Japanese POEMS syndrome with Thalidomide (J-POST) Trial is a phase II/III multicentre, double-blinded, randomised, controlled trial that aims to evaluate the efficacy and safety of a 24-week treatment with thalidomide in POEMS syndrome, with an additional 48-week open-label safety study. Adults with POEMS syndrome who have no indication for transplantation are assessed for eligibility at 12 tertiary neurology centres in Japan. Patients who satisfy the eligibility criteria are randomised (1:1) to receive thalidomide (100-300 mg daily) plus dexamethasone (12 mg/m(2) on days 1-4 of a 28-day cycle) or placebo plus dexamethasone. Both treatments were administered for 24 weeks (six cycles; randomised comparative study period). Patients who complete the randomised study period or show subacute deterioration during the randomised period participate in the subsequent 48-week open-label safety study (long-term safety period). The primary end point of the study is the reduction rate of serum VEGF levels at 24 weeks.
    Ethics and dissemination: The protocol was approved by the Institutional Review Board of each hospital. The trial was notified and registered at the Pharmaceutical and Medical Devices Agency, Japan (No. 22-1716). The J-POST Trial is currently ongoing and is due to finish in August 2015. The findings of this trial will be disseminated through peer-reviewed publications and conference presentations and will also be disseminated to participants.

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  • Deep grey matter involvement in multiple sclerosis: key player or bystander? Reviewed

    Izumi Kawachi

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   85 ( 12 )   1293 - 1293   2014.12

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  • Immune-mediated hypertrophic pachymeningitis: Clinical significance of anti-neutrophil cytoplasmic antibody and granulomatosis with polyangiitis (Wegener's granulomatosis) Invited Reviewed

    Akiko Yokoseki, Masatoyo Nishizawa, Izumi Kawachi

    Clinical and Experimental Neuroimmunology   5 ( 3 )   275 - 276   2014.10

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    DOI: 10.1111/cen3.12117

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  • Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis Reviewed

    Masaaki Niino, Nobuhiro Mifune, Tatsuo Kohriyama, Masahiro Mori, Takashi Ohashi, Izumi Kawachi, Yuko Shimizu, Hikoaki Fukaura, Ichiro Nakashima, Susumu Kusunoki, Katsuichi Miyamoto, Kazuto Yoshida, Takashi Kanda, Kyoichi Nomura, Takashi Yamamura, Fumihito Yoshii, Jun-Ichi Kira, Shunya Nakane, Kazumasa Yokoyama, Makoto Matsui, Yusei Miyazaki, Seiji Kikuchi

    Clinical and Experimental Neuroimmunology   5 ( 3 )   328 - 335   2014.10

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    Objective The aim of the present study was to investigate the association of magnetic resonance imaging (MRI) findings and social activity with cognitive function in Japanese patients with multiple sclerosis (MS).
    Methods The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was carried out in 184 Japanese patients with MS, and 163 controls matched for age, sex and education. MRI findings of cerebral, brainstem, and cerebellar lesions and social activities of MS patients were further examined.
    Results MS patients with higher numbers of cerebral lesions on MRI had lower scores in most BRB-N tests. BRB-N scores in the majority of tests were significantly lower in patients with brainstem and cerebellar lesions. Data from an analysis of variance model in which only the main effects of cerebral, brainstem and cerebellar lesions were hypothesized showed an association of cerebral lesions with decreased scores in all BRB-N tests, except symbol digit modalities test (SDMT) and paced auditory serial addition test (PASAT). In contrast, cerebellar lesions were associated with decreased SDMT and PASAT scores. Patients categorized as "unemployed because of MS" had lower BRB-N scores than other social activity groups. Lower SDMT scores had an effect on the "unemployed because of MS" group, whereas the Expanded Disability Status Scale had a significantly greater negative impact on patients in this social category.
    Conclusions Higher numbers of brain lesions on MRI could have an impact on cognitive function in patients with MS, and impairment of information processing appears significantly associated with cerebellar lesions. Cognitive impairment affects the employment status of patients with MS.

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  • Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis Reviewed

    Masaaki Niino, Nobuhiro Mifune, Tatsuo Kohriyama, Masahiro Mori, Takashi Ohashi, Izumi Kawachi, Yuko Shimizu, Hikoaki Fukaura, Ichiro Nakashima, Susumu Kusunoki, Katsuichi Miyamoto, Kazuto Yoshida, Takashi Kanda, Kyoichi Nomura, Takashi Yamamura, Fumihito Yoshii, Jun-ichi Kira, Shunya Nakane, Kazumasa Yokoyama, Makoto Matsui, Yusei Miyazaki, Seiji Kikuchi

    BMC NEUROLOGY   14   3 - 3   2014.1

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    Background: Cognitive impairment could affect quality of life for patients with multiple sclerosis (MS), and cognitive function may be correlated with several factors such as depression and fatigue. This study aimed to evaluate cognitive function in Japanese patients with MS and the association between cognitive function and apathy, fatigue, and depression.
    Methods: The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was performed in 184 Japanese patients with MS and 163 healthy controls matched for age, gender, and education. The Apathy Scale (AS), Fatigue Questionnaire (FQ), and Beck Depression Inventory Second Edition (BDI-II) were used to evaluate apathy, fatigue, and depression, respectively. Student's t-test was used to compare MS patients and healthy controls. Correlations between two factors were assessed using the Pearson correlation test, and multiple regression analysis was used to evaluate how much each factor affected the BRB-N score.
    Results: In all BRB-N tests, patients with MS scored significantly lower than controls, and the effect size of symbol digit modalities test was the highest among the 9 tests of the BRB-N. Patients with MS had higher AS (p &lt; 0.001), FQ (p &lt; 0.0001), and BDI-II (p &lt; 0.0001) scores than controls. In patients with MS, scores on most of the BRB-N tests correlated with scores on the AS and BDI-II; however, there was little correlation between scores on the BRB-N tests and those on the FQ.
    Conclusions: Cognitive function was impaired, particularly information-processing speed, and decreased cognitive function was correlated with apathy and depression in Japanese patients with MS. Despite the association between cognitive variables and depression/apathy, cognitive function was impaired beyond the effect of depression and apathy. However, subjective fatigue is not related with cognitive impairment. Taken together, this suggests that different therapeutic approaches are needed to improve subjective fatigue and cognition, and thereby quality of life, in patients with MS.

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  • Can Anti-AQP4 Antibody Damage the Blood-Brain Barrier? Reviewed

    Miho Akaza, Keiko Tanaka, Masami Tanaka, Teruhiko Sekiguchi, Tamako Misawa, Kazutaka Nishina, Izumi Kawachi, Masatoyo Nishizawa, Hidehiro Mizusawa, Takanori Yokota

    EUROPEAN NEUROLOGY   72 ( 5-6 )   273 - 277   2014

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    Background: Aquaporin 4 (AQP4) is a water-channel protein predominantly expressed in astrocyte end feet that make up the blood-brain barrier (BBB). Recently, anti-AQP4 antibody has been identified as a specific biomarker of neuromyelitis optica (NMO). However, whether anti-AQP4 antibodies damage the BBB is unclear. Methods: We evaluated BBB damage in patients with NMO and multiple sclerosis by measuring albumin leakage (AL) and studied its correlation with anti-AQP4 antibody. Results: No obvious difference in AL was observed between patients with and without anti-AQP4 antibodies. In the multivariate analysis, anti-AQP4 antibody was not associated with BBB damage. Of the anti-AQP4-positive patients, 58.0% had normal AL values, and the degree of BBB damage was unrelated to the anti-AQP4 antibody titer. In addition, 41.9% of anti-AQP4-positive patients showed no gadolinium enhancement of the MRI. Conclusion: These results indicate that the presence of anti-AQP4 antibody alone in plasma is insufficient to disrupt the BBB. (C) 2014 S. Karger AG, Basel

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  • Gray matter lesions and cognitive impairment in multiple sclerosis

    Izumi Kawachi, Etsuji Saji, Masatoyo Nishizawa

    Clinical Neurology   54 ( 12 )   1060 - 1062   2014

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    Multiple sclerosis (MS) has long been considered to be the autoimmune disease that primarily affects oligodendrocyte and myelin in the white matter (WM) of the CNS. However, renewed interest in the gray matter (GM) pathology including cortical and deep GM of MS is emerging. Radiological and pathological assessments demonstrate that substantial cortical demyelination is prominent in all stages or courses of MS, and cortical neurodegeneration is also present in even normal-appearing GM in MS. Patients with MS have cognitive impairment as represented by the latent start of impairment from the very early stage of the disease course, and not only WM lesions but also GM lesions might be good predictors for cognitive impairment in MS. Although the cause of the GM lesions in MS has not been fully determined, an increase in knowledge of the structure of GM lesions in MS brains will result in more targeted therapeutic approaches to the disease.

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  • Efficacy of methylprednisolone pulse therapy for acute relapse in Japanese patients with multiple sclerosis and neuromyelitis optica: A multicenter retrospective analysis - 1. Whole group analysis Reviewed

    Jun-Ichi Kira, Ryo Yamasaki, Satoshi Yoshimura, Toshiyuki Fukazawa, Kazumasa Yokoyama, Kazuo Fujihara, Mieko Ogino, Takanori Yokota, Katsuichi Miyamoto, Masaaki Niino, Kyoichi Nomura, Ryo Tomioka, Masami Tanaka, Izumi Kawachi, Takashi Ohashi, Kenichi Kaida, Makoto Matsui, Yuji Nakatsuji, Hirofumi Ochi, Hikoaki Fukaura, Takashi Kanda, Akiko Nagaishi, Kanae Togo, Hidehiro Mizusawa, Yuji Kawano

    Clinical and Experimental Neuroimmunology   4 ( 3 )   305 - 317   2013.12

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    Objectives There has been no large-scale study of methylprednisolone pulse therapy in Asian patients with multiple sclerosis (MS) or neuromyelitis optica (NMO), despite it being widely used for acute relapse. We aimed to clarify treatment response of MS and NMO patients to methylprednisolone pulse therapy and post-pulse oral corticosteroids in real clinical practice in a multicenter study in Japan. Methods Investigators at 28 institutions collected changes in neurological symptoms/signs and Expanded Disability Status Scale (EDSS) scores before and within 1 week of completion of methylprednisolone pulse therapy carried out in 2010, and after post-pulse oral corticosteroids therapy, by retrospective review of medical records. Results In 345 patients (95.1% of all registered patients), 457 series of methylprednisolone pulse therapy were carried out for treatment of acute relapse. EDSS scores improved by 0.8 ± 1.1 (mean ± SD) after the first course. The second and third courses also produced sufficient improvements (by 0.7 and 0.6, respectively), but much smaller improvements were observed thereafter. The target neurological symptoms and signs improved in 79.5% of patients. Improvement rates were 5-20% lower after a course of pulse therapy than after a series of pulse therapy. A half dose (500 mg/day) produced less improvement than a standard dose (1000 mg/day
    65.9 vs 79.5%). During post-pulse oral corticosteroid therapy, EDSS scores decreased by 0.6 ± 0.9. No significant adverse effects were observed. Conclusions Methylprednisolone pulse therapy is beneficial in nearly 80% of Japanese MS and NMO patients, and EDSS score improvements after therapy are compatible with those in Western MS patients. © 2013 Japanese Society for Neuroimmunology.

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  • T lymphocytes: Helpers Invited Reviewed

    KAWACHI Izumi, KONDO Takayuki

    ENCYCLOPEDIA OF LIFE SCIENCES   2013.9

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  • Dropped head syndrome in amyotrophic lateral sclerosis Reviewed

    Masahiro Uemura, Takayuki Kosaka, Takayoshi Shimohata, Masanori Ishikawa, Yasushi Nishihira, Yasuko Toyoshima, Kaori Yanagawa, Izumi Kawachi, Hitoshi Takahashi, Masatoyo Nishizawa

    Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration   14 ( 3 )   232 - 233   2013.4

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  • Semiquantitative measurement of aquaporin-4 antibodies as a possible surrogate marker of neuromyelitis optica spectrum disorders with systemic autoimmune diseases Reviewed

    Yasuhiro Katsumata, Izumi Kawachi, Yasushi Kawaguchi, Takahisa Gono, Hisae Ichida, Masako Hara, Hisashi Yamanaka

    Modern Rheumatology   22 ( 5 )   676 - 684   2012.9

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    Objectives To assess the association between serum aquaporin-4 (AQP4) autoantibodies and neuromyelitis optica spectrum disorders (NMOSDs) associated with systemic autoimmune diseases. Methods We retrospectively studied 626 hospitalized patients with systemic lupus erythematosus (SLE) or Sjö- gren's syndrome (SS). We collected serum samples from those patients with suspected NMOSDs (i.e., myelitis or optic neuritis) at the time of onset and thereafter. AQP4 antibodies were measured by a cell-based indirect immunofluorescence assay using AQP4-transfected HEK-293 cells in a semi-quantitative manner. Results Sera from 6 patients with suspected NMOSDs and SLE (n = 3) or SS (n = 3) were evaluated. Among these, 2 patients' sera samples, i.e., 1 with SLE and 1 with SS, were positive for AQP4 antibodies. There was an inverse relationship between disease amelioration and antibody titer in one NMOSD patient, whereas the antibody titer remained high in the other NMOSD patient, whose clinical manifestations of NMOSDs did not improve despite intensive immunosuppressive treatments. Conclusions These results indicate that serum AQP4 antibodies are present in some SLE/SS patients with myelitis/optic neuritis and might be associated with clinical outcomes. The semi-quantitative measurement of the AQP4 antibody might be a possible surrogate marker in patients with NMOSDs associated with systemic autoimmune diseases. © Japan College of Rheumatology 2012.

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  • Neuromyelitis optica following thymectomy with severe spinal cord atrophy after frequent relapses for 30 years Reviewed

    Masaya Hironishi, Shinji Ishimoto, Tadashi Sawanishi, Hideto Miwa, Izumi Kawachi, Tomoyoshi Kondo

    Brain and Nerve   64 ( 8 )   951 - 955   2012.8

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    A 60-year-old woman had frequent relapses of neuromyelitis optica (NMO) for 30 years despite receiving steroid and azathioprine therapy. She developed MGFA Class IIIb type of myasthenia gravis (MG) at the age of 23, and thymectomy resulted in complete remission of MG. The initial symptoms of NMO, including headache, high fever, retrobulbar optic neuritis, and neurogenic bladder, appeared at the age of 30. Two years later, paraplegia also developed. Although she received oral administration of steroids or azathioprine and intravenous steroid pulse therapy for treatment of NMO for over 30 years, she experienced frequent relapses. The examination at the ages of 58 and 60 years showed that anti-aquaporin-4 antibody was absent. Intravenous immunoglobulin therapy administered in January and June 2009 was effective, and she had 2 years of remission of NMO attack. Spinal MRI after frequent NMO attacks for 30 years revealed an extended spinal cord atrophy involving the lower cervical region and the entire thoracic region. We describe and discuss the prognosis of NMO and the effectiveness of therapies in an NMO patient who underwent thymectomy for MG.

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  • Chorea as the first sign in a patient with elderly-onset systemic lupus erythematosus. Reviewed International journal

    Ariizumi Yuko, Ozawa Tetsutaro, Tokutake Takayoshi, Kawachi Izumi, Hirose Masaki, Katada Shinichi, Igarashi Shuichi, Tanaka Keiko, Nishizawa Masatoyo

    Case Rep Neurol Med   2012   317082 - 317082   2012

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    The case of an elderly patient who had chorea as an initial symptom of systemic lupus erythematosus (SLE) accompanied by antiphospholipid syndrome (APS) is reported. A 68-year-old woman suddenly developed chorea of her left arm and leg. Magnetic resonance imaging (MRI) of the brain demonstrated a focal lesion in the right caudate head, which showed hyperintensity on fluid-attenuated inversion recovery and diffusion-weighted imaging. This condition was thought to be a common form of vascular chorea, which is likely to occur in elderly individuals; however, the laboratory data of this patient finally fulfilled the diagnostic criteria of SLE and APS. Physicians should be careful in diagnosing elderly individuals simply as having a vascular chorea because this symptom can be the initial manifestation of SLE or APS.

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  • [Successful treatment of neuroborreliosis with combined administration of antibiotics and steroids: a case report]. Reviewed

    Yuhei Takado, Takayoshi Shimohata, Izumi Kawachi, Keiko Tanaka, Masatoyo Nishizawa

    Rinsho shinkeigaku = Clinical neurology   52 ( 6 )   411 - 415   2012

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    A 66-year-old woman developed bilateral facial paralysis as well as sensory and motor disturbances of extremities. Two months after the onset of paralysis, she also developed sensory disturbance of her trunk and vesicorectal disturbance, and her symptoms worsened gradually. Because the interferon-γ level in the cerebrospinal fluid was elevated, we suspected that her symptoms were caused by polyneuropathy and myelitis associated with infection. Her serum IgM and IgG antibodies against Borrelia garinii and B. afzelli were positive. Therefore, we diagnosed her as having neuroborreliosis. Her symptoms gradually improved after the combined administration of antibiotics and steroids. The present case report showed that it might be better to consider the possibility of neuroborreliosis when there are increasing concentrations of cytokine and chemokine, and that combination treatment with antibiotics and steroids can be used for the treatment of this disease.

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  • A case of inflammatory myopathy with widely skin rash following use of supplements containing Spirulina Reviewed

    Takuya Konno, Yoshitaka Umeda, Maiko Umeda, Izumi Kawachi, Mutsuo Oyake, Nobuya Fujita

    Clinical Neurology   51 ( 5 )   330 - 333   2011.5

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    A 49-year old woman noticed her skin rash several days after taking supplements containing Spirulina, a planktonic blue-green alga. Her skin rash was spreading over large parts of her body, even after stop ingestion two months later. Five months later, she developed muscle weakness of neck flexor and left proximal upper extremity. On admission, creatine kinase (CK) was elevated to 1,268 IU/m/ in the serum. A muscle specimen revealed many necrotizing muscle fibers and the infiltration of mononuclear cells in the peri- and endomysium including a lot of eosinophils. Immunohistochemical staining showed the infiltration of CD4 positive cells in the periand endomysium and that of CD20 positive B cells in the perivascular regions. She was diagnosed as having inflammatory myopathy with widely skin rash. Therapy with administration of prednisolone and cyclophosphamide followed by methyl-prednisolone pulse improved her clinical symptoms. There is a similar report describing a case of dermatomyositis after ingestion of Spirulina, which is known to have immune-stimulating property such as accelerating tumor necrosis factor (TNF)-α production. Also, TNF-α single nucleotide polymorphisms (TNF-308A) was demonstrated to have strong association with onset of myositis in Caucasians. The use of Spirulina could result in inflammatory myopathy under some specific conditions.

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  • Diagnosis and Management of Paraneoplastic Neurological Syndromes Invited

    Etsuji Saji, Izumi Kawachi, Masatoyo Nishizawa

    Brain and Nerve   62 ( 4 )   319 - 330   2010.4

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    Paraneoplastic neurological syndromes (PNS) are infrequent tumor-related disorders that are not caused by direct tumor invasion or metastases, metabolic and nutritional deficits, infections, coagulopathy, or the side effects of cancer treatment. PNS can affect any part of the central and peripheral nervous systems, the neuromuscular junction, or muscles. Because the onset of PNS often antedates the diagnosis of an underlying cancer, it is difficult to establish a definitive early diagnosis. Therefore, it is important for neurologists to consider the possibility of PNS when rapidly progressive neurological syndromes cannot be explained by other causes. Detection of onconeural antibodies is useful for diagnosing PNS, and detection of specific antibodies can aid the identification of the underlying tumor. However, not all patients with PNS have onconeural antibodies, and not all patients with onconeural antibodies have PNS. Although PNS are considered to be mediated by the immune system, various forms of immunotherapy have yielded disappointing results, with some exceptions (i.e., PNS cases with antibodies against neuronal cell-surface antigens such as N-methyl-D-aspartate receptors). The lack of clinical trials due to the rarity of patients with PNS makes it difficult to test the efficacy of immunomodulatory treatment. Rapid detection and immediate treatment of the underlying tumor is an important approach that offers the highest chances of improvilng or stabilizing the syndrome before irreversible neuronal damage occurs. In this review, we discuss the diagnostic criteria and management of PNS based on the PNS Euronetwork and other reports.

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  • 11. Hypertrophic Pachymeningitis Invited

    Kawachi Izumi, Nishizawa Masatoyo

    Nihon Naika Gakkai Kaishi   99 ( 8 )   1821 - 1829   2010

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    DOI: 10.2169/naika.99.1821

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    Other Link: https://jlc.jst.go.jp/DN/JALC/00355107768?from=CiNii

  • Humoral and cellular immune responses in neuromyelitis optica

    Izumi Kawachi

    Clinical Neurology   50 ( 11 )   873 - 874   2010

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    Neuromyelitis optica (NMO) is an inflammatory and demyelinating syndrome characterized by severe attacks of myelitis and optic neuritis. A crucial role for humoral immunity in the NMO pathogenesis has been suggested by the detection of a highly specific serum autoantibody NMO immunoglobulin G that binds to aquaporin4 (AQP4) water channels, and the pronounced deposition of immunoglobulins colocalizing with products of complement activation in a vasculocentric pattern around thickened hyalinized blood vessels in NMO lesions. Moreover, we have recently demonstrated that levels of several cytokines such as interleukin (IL)-6 and IL-1β are increased in the cerebrospinal fluid of NMO patients, and the peripheral white matter-demyelinating cord lesions of NMO were accompanied by infiltration of lymphocytes in the leptomeningeal membrane. These cellular elements in patients with NMO might aid B cells and plasma cells in AQP4 antibody production, and break the blood-brain barrier due to the access of AQP4 antibodies to the extracellular domain of AQP4 at the astrocytic foot process.

    DOI: 10.5692/clinicalneurol.50.873

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  • Multifocal fibrosclerosisと神経系 肥厚性硬膜炎を伴うmultifocal fibrosclerosis Reviewed

    他田正義, 小野寺理, 赤岩靖久, 河内泉, 西澤正豊

    神経内科   71 ( 2 )   170 - 175   2009.8

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  • A patient with limbic encephalitis associated with anti-voltage-gated potassium channel antibodies who presented with insomnia and hand tremor Reviewed

    TAKADO Yuhei, SHIMOHATA Takayoshi, TOKUNAGA Jun, KAWACHI Izumi, TANAKA Keiko, NISHIZAWA Masatoyo

    Clinical neurology.   48 ( 5 )   338 - 342   2008.5

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    DOI: 10.5692/clinicalneurol.48.338

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    Other Link: http://search.jamas.or.jp/link/ui/2008235962

  • An autopsy case of dementia with lewy bodies showing autonomic failure and dementia as the initial symptoms Reviewed

    Masato Kanazawa, Kazuhiro Sanpei, Yasuko Toyoshima, Izumi Kawachi, Yoshiaki Honma, Hitoshi Takahashi

    MOVEMENT DISORDERS   22 ( 8 )   1212 - 1213   2007.6

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    DOI: 10.1002/mds.21523

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  • Gene diagnosis of patients with chorea Reviewed

    Takayoshi Shimohata, Osamu Onodera, Yoshiaki Honma, Koichi Hirota, Yasuhito Nunomura, Tetsuya Kimura, Izumi Kawachi, Kazuhiro Sanpei, Masatoyo Nishizawa, Shoji Tsuji

    Clinical Neurology   44 ( 3 )   149 - 153   2004.3

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    To elucidate the etiology of chorea, we performed gene diagnoses of 79 consecutive cases of the disease (34 males, 45 females
    age 15-79 years), which include 39 familial cases (37 pedigrees) and 40 sporadic cases, from 1997 to 2002, after their informed consent was obtained. We extracted genomic DNA from peripheral white blood cells, and performed genetic tests for Huntington disease (HD), dentatorubral pallidoluysian atrophy (DRPLA), Huntington disease like 1 (HDL1), HDL2 and spinocerebellar ataxia type 17 (SCA17). We found 37 cases (36 pedigrees) of HD, seven cases (seven pedigrees) of DRPLA. No cases of HDL1, HDL2 and SCA17 were found. We also found three cases (two pedigrees) presenting an autosomal dominant trait with an unknown origin, and two cases whose parents were consanguineously related. Therefore, further genetic heterogeneity is expected in the cases of chorea in Japan.

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  • Steroid-pulse therapy in Guillain-Barré syndrome associated with cytomegalovirus infection: A case report Reviewed

    Masayoshi Tada, Osamu Onodera, Izumi Kawachi, Kenju Hara, Masahisa Sato, Hiide Yoshino, Atsuko Asano, Yoshiaki Soma, Shoji Tsuji

    Brain and Nerve   55 ( 7 )   615 - 621   2003.7

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    We report a 27-year-old man with Guillain-Barré syndrome (GBS) preceded by cytomegalovirus infection. He was admitted to our hospital because of distal dominant weakness and sensory disturbance 5 days after fever. Double filtration plasmapheresis (DFPP) was performed and clinical symptoms temporary but dramatically improved. However facial nerve palsy, difficulty in swallowing food, weakness, dysautonomia and respiratory failure rapidly progressed within 5 days áfter the onset. Repeated DFPP failed to improve his symptoms. Two months after the onset, he did not improve at all. On T1-weighted MRI, nerve roots were still enhanced with gadolinium, and CSF examination revealed 1,324 mg/dl of protein. These findings suggested us the existence of continuous inflammation on nerve roots. We gave steroid-pulse therapy. He dramatically improved after this treatment. We repeated steroid-pulse therapy for seven times. He was discharged without any major complication 6 months after the onset. Steroid-pulse therapy should be considered in GBS patients associated with CMV infection when other conventional treatments are ineffective.

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  • Mechanism of Autoimmunity in Human Polymyositis, Based on the Experimental Allergic Myositis Induced by Inoculating Dendritic Cells. Reviewed

    河内泉

    新潟医学会雑誌・新潟大学   116 ( 11 )   546 - 565   2002.11

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  • Acute 5-FU-induced leukoencephalopathy with remarkable diffuse high-signal lesion in the white matter in MRI diffusion image Reviewed

    Otake H, Hozumi I, Kawachi I, Soma Y, Tsuji S

    Neurological Medicine   53 ( 1 )   83 - 85   2000.7

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  • Monitoring of the cryptococcus count in the cerebrospinal fluid with negative cultures in two cases of serious cryptococcal meningitis Reviewed

    T. Ozawa, T. Anezaki, T. Ohara, T. Sakai, R. Nakano, M. Isoda, T. Takahashi, A. Arai, H. Kobayashi, M. Endo, H. Takano, I. Kawachi, Y. Toyoshima, H. Takahashi, Y. Soma, S. Tsuji

    Brain and Nerve   52 ( 8 )   729 - 733   2000

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    We monitored the cryptococcus count in the cerebrospinal fluid (CSF) using the filter technique in two cases of serious cryptococcal meningitis during the course of treatment with antifungal agents. Lumbar puncture was performed once a week, and 1 ml of CSF was filtered through a Millipore filter (5.0- μ m pore for cells), followed by staining of the filters with Alcian blue. All of the cryptococci on the filter were counted under a light microscope at a magnification of x 100. More than 500/ml and 2,000/ml Of cryptococci were still observed in the CFS in Cases 1 and 2, respectively, in whom CFS cultures for Cryptococcus neoformans became negative after 4 weeks of treatment. Even though the treatment with antifungal agents were continued in these cases, cryptococci could still be observed for 5 weeks and 60 weeks on the filter preparations of Cases 1 and 2, respectively, after the CSF cultures became negative. The cryptococcal antigen could also be detected in the CSF during the positive filter preparations in these cases. At autopsy in Case 2, patchy lepromeningeal inflammatory lesions with the characteristic capsules of cryptococci were observed in the subarachnoid space. These observations suggest that cryptococci, which persisted in the CSF despite the negαfive cultures, were responsible for the lesions in the subarachnoid space and protracted clinical course in the two cases of cryptococcal meningitis.

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  • Occurrence of argyrophilic grains in multiple system atrophy: Histopathological examination of 26 autopsy cases Reviewed

    Koichi Wakabayashi, Izumi Kawachi, Yasuko Toyoshima, Hitoshi Takahashi

    Brain and Nerve   51 ( 5 )   433 - 437   1999

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    Argyrophilic grain disease (AGD) is a progressive disorder producing dementia in elderly individuals characterized by the presence of numerous AGs in the limbic system. However, the occurrence of AGs has been reported in other neurodegenerative conditions including Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration, all of which show tau-positive cytoskeletal abnormalities. We examined the brains of 26 patients with multiple system atrophy(MSA), a neurodegenerative disorder fundamentally lacking tau pathology, histologically and immunocytochemically. Numerous AGs were found in the limbic system in 5 patients, of whom two had shown mild dementia. Immunocytochemically, these AGs were labeled with antibodies against phosphorylation-dependent and -independent tau protein, but not alpha-synuclein, whereas oligodendroglial cytoplasmic inclusions found exclusively in MSA were immunoreactive for alpha-synuclein and, less consistently, for phosphorylation-independent tau but not for phosphorylation-dependent tau protein. Furthermore, many phosphorylation- dependent tau-positive neurons and significant numbers of ballooned neurons (BNs) were found in the limbic system in all of the 5 patients with AGs. These findings suggest that AGs can occur with relatively high frequency in the limbic system of MSA patients, and that as in AGD, they may be accompanied by tau-positive neurons and BNs.

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  • A case of post-irradiation lumbosacral radiculopathy successfully treated with corticosteroid and warfarin Reviewed

    T. Anezaki, T. Harada, I. Kawachi, K. Sanpei, Y. Soma, S. Tsuji

    Clinical Neurology   39 ( 8 )   825 - 829   1999

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    A 33-year-old man underwent post-operative radiation therapy for the left testicular anaplastic seminoma. One year later, the patient developed muscle weakness and sensory disturbance in the left lower extremity, and muscle weakness in the right lower extremity. MRI demonstrated linear and focal gadolinium (Gd) enhancement of the anterior portion of the lumbosacral roots within the cauda equina. The neurological symptoms improved after administration of corticosteroid and warfarin. Radiation myelopathy of this type was classified as 'selective anterior horn cell injury or amyotrophy' by Reagan, and the site of the lesion was considered to be the lower motor neurons. However, based on the clinical and MRI findings, we proposed that the disease process was injury to the spinal nerve roots rather than the lower motor neurons. Recent neuropathological studies of this syndrome have demonstrated degeneration of the proximal spinal nerve roots. We consider that primary lesions of this syndrome occur in spinal nerve roots rather than in lower motor neurons, and 'lumbosacral radiculopathy' is a more appropriate term for this condition.

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Books

  • COVID-19神経ハンドブック : 急性期、後遺症からワクチン副反応まで

    河内泉 (下畑享良編集)( Role: Contributor ,  COVID-19における免疫応答 -Neuro-COVID-19を理解するために- (44-51頁))

    中外医学社  2022.5  ( ISBN:9784498328860

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  • 脳神経内科診断ハンドブック = Handbook for diagnosis on neurology

    河内泉 (下畑享良編集)( Role: Contributor ,  H. 脱髄性疾患. 非感染性炎症性疾患. 3-1. 肥厚性硬膜炎 (257-262頁))

    中外医学社  2022.1  ( ISBN:9784498328785

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  • 今日の治療指針 : 私はこう治療している

    河内泉 (福井次矢, 高木誠, 小室, 一成 総編集)( Role: Contributor ,  自己免疫性脳炎・脳症 (975-976頁))

    医学書院  2022.1  ( ISBN:9784260047760

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  • ベーチェット病診療ガイドライン

    河内泉, その他 (神経病変分科会・協力). 厚生労働科学研究費補助金, 難治性疾患政策研究事業, ベーチェット病に関する調査研究班, 厚生労働科学研究費補助金, 難治性疾患政策研究事業, 難治性炎症性腸管障害に関する調査研究班, 厚生労働省, 水木, 信久, 竹内, 正樹, 日本ベーチェット病学会( Role: Contributor ,  140-147頁)

    診断と治療社  2020.1  ( ISBN:9784787824042

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  • 『今日の疾患辞典』デジタル版 (Current Decision Support)

    河内泉 (水澤英洋総合編集委員)( Role: Contributor ,  白質脳症(総論)https://www.cds.ai/docs/detail/d09425_indd)

    プレシジョン. 東京  2019.5 

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  • 『今日の疾患辞典』デジタル版 (Current Decision Support)

    河内泉 (水澤英洋総合編集委員)( Role: Contributor ,  放射線脊髄症 https://www.cds.ai/docs/detail/d09435_indd)

    プレシジョン. 東京.  2019.5 

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  • 『今日の疾患辞典』デジタル版 (Current Decision Support)

    河内泉 (水澤英洋総合編集委員)( Role: Contributor ,  放射線治療後の神経叢障害 https://www.cds.ai/docs/detail/d09436_indd)

    プレシジョン. 東京.  2019.5 

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  • 『今日の疾患辞典』デジタル版 (Current Decision Support)

    河内泉 (水澤英洋総合編集委員)( Role: Contributor ,  横断性脊髄炎 https://www.cds.ai/docs/detail/d09434_indd)

    プレシジョン. 東京.  2019.5 

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  • 『今日の疾患辞典』デジタル版 (Current Decision Support)

    河内泉 (水澤英洋総合編集委員)( Role: Contributor ,  可逆性の脳梁膨大部病変を伴う軽症脳炎・脳症 https://www.cds.ai/docs/detail/d09420_indd)

    プレシジョン. 東京  2019.5 

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  • 神経内科Clinical Questions & Pearls 中枢脱髄性疾患

    河内 泉 (鈴木則宏監修)( Role: Contributor ,  NMOはどのような病気か教えてください. II. 疾患概念と臨床症状 (30-39頁))

    中外医学社  2018.2  ( ISBN:9784498328006

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  • 多発性硬化症・視神経脊髄炎診療ガイドライン2017

    河内泉, その他 (「多発性硬化症・視神経脊髄炎診療ガイドライン」作成委員会) (日本神経学会監修)( Role: Contributor)

    医学書院  2017.6  ( ISBN:9784260030601

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  • アクチュアル脳・神経疾患の臨床. 免疫性神経疾患—病態と治療のすべて

    河内 泉, 西澤 正豊 (吉良潤一・辻省次編)( Role: Contributor ,  III. 免疫を治す−治療薬・治療法. 免疫抑制薬 (164-172頁)

    中山書店  2016.3  ( ISBN:4521743315

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  • 新しい診断と治療のABC 82 神経関連感染症 神経7. 最新医学別冊

    河内 泉, 西澤 正豊 (水澤英洋編)( Role: Contributor ,  第3章神経感染症各論. 慢性髄膜炎と髄膜脳炎 (81-90頁))

    最新医学社  2014.4 

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  • アクチュアル脳・神経疾患の臨床. 多発性硬化症と視神経脊髄炎

    河内 泉, 西澤 正豊 (吉良潤一・辻省次編集)( Role: Contributor ,  III. 視神経脊髄炎の病態と治療. NMO spectrum disorder (331-337頁))

    中山書店  2012.10  ( ISBN:4521734413

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  • 多発性硬化症 (MS) と視神経脊髄炎 (NMO) の基礎と臨床

    河内 泉 (藤原一男編集)( Role: Contributor ,  II. MSとNMOの基礎. 2. 免疫制御のキープレイヤーとネットワーク (33-45頁))

    医薬ジャーナル社  2012.9  ( ISBN:4753225763

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  • アクチュアル脳・神経疾患の臨床. 認知症 神経心理学的アプローチ

    河内 泉, 西澤 正豊 (河村満・辻省次編集)( Role: Contributor ,  III. 認知症をきたす疾患. 多発性硬化症 (256-270頁))

    中山書店  2012.3  ( ISBN:4521734391

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  • 脳神経内科診断ハンドブック = Handbook for diagnosis on neurology 改訂第2版

    河内泉 (下畑享良 編集)( Role: Contributor ,  H. 脱髄性疾患. 非感染性炎症性疾患. 3-1. 肥厚性硬膜炎 (260-268頁))

    中外医学社  2024.3  ( ISBN:9784498328792

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    Total pages:ix, 614p   Language:Japanese

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  • 今日の治療指針 : 私はこう治療している

    河内泉 (福井次矢, 高木誠, 小室一成, 阿部理一郎 編集)( Role: Contributor ,  悪性腫瘍の遠隔効果による神経障害 (1016-1018頁))

    医学書院  2024.1  ( ISBN:9784260053426

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    Total pages:59, 2174p   Language:Japanese

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  • 多発性硬化症・視神経脊髄炎スペクトラム障害診療ガイドライン

    日本神経学会, 「多発性硬化症・視神経脊髄炎スペクトラム障害診療ガイドライン」作成委員会( Role: Contributor)

    医学書院  2023.9  ( ISBN:9784260053532

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    Total pages:xix, 301p   Language:Japanese

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  • 救急、プライマリ・ケアでの神経診療がわかる、できる! : 重要疾患を見抜く病歴聴取・神経診察を脳神経内科のエキスパートがやさしく教えます

    渡邉緑, 河内泉 (安藤孝志 編集)( Role: Contributor ,  第3章 状況ごとの診療のコツ, エキスパートが教えます! 8. MS・NMOSD・ADEMを含めた自己免疫性中枢神経疾患を考えるタイミング (1499-1510頁))

    羊土社  2023.8  ( ISBN:9784758127028

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    Total pages:261p   Language:Japanese

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  • 自己免疫性脳炎・関連疾患ハンドブック = Handbook of Autoimmune Encephalitis and Related Disorders

    河内泉 (下畑享良 編集)( Role: Contributor ,  自己免疫性脳炎・脳症の治療 (29-42頁))

    金芳堂  2023.5  ( ISBN:9784765319560

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    Total pages:vii, 363p   Language:Japanese

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MISC

  • 視神経脊髄炎スペクトラム (NMOSD) の病理・病態. II. 中枢神経脱髄疾患. 免疫性神経疾患 (第2版) -基礎・臨床の最新知見− Invited

    中島章博, 佐治越爾, 河内泉

    日本離床   80 ( 増刊号5号 )   178 - 182   2022.5

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  • 肥厚性硬膜炎. IV. 脱髄以外の中枢神経免疫疾患. 免疫性神経疾患 (第2版) -基礎・臨床の最新知見− Invited

    佐治越爾, 河内泉

    日本臨床   80 ( 増刊号5号 )   334 - 339   2022.5

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  • 視神経脊髄炎スペクトラム障害 (NMOSD) Q2. B細胞をターゲットとする治療薬を選択する際の留意点はありますか Invited

    河内泉

    臨床のあゆみ   112.1   https://medical.mt-pharma.co.jp/articles/rinsho-ayumi/member/112/qa3.shtml   2022.2

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  • 視神経脊髄炎スペクトラム (NMOSD). Clinical Science. 膠原病・自己免疫疾患と神経障害―診断と治療の進歩 Invited

    河内泉

    炎症と免疫   30 ( 4 )   47(343) - 52(348)   2022

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  • モノクローナル抗体の意義. A. モノクローナル抗体の基礎 Invited

    河内泉

    Clinical Neuroscience   39 ( 12 )   1472 - 1476   2021

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  • 視神経脊髄炎の臨床像と自然経過. 特集: 多発性硬化症と視神経脊髄炎update. 基礎・臨床研究の最新知見. II. 脱髄性疾患の診断update Invited

    河内泉

    日本臨床   79 ( 10 )   1521 - 1527   2021

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  • Diagnosis and Treatments of Hypertrophic Pachymeningitis Invited

    Akihiro Nakajima, Izumi Kawachi

    Spinal Surgery   34 ( 1 )   25 - 31   2020.8

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    Authorship:Last author, Corresponding author   Publisher:Japanese Society of Spinal Surgery  

    DOI: 10.2531/spinalsurg.34.25

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  • 多発性硬化症のトピック2020年〜患者さん一人ひとりに寄り添う医療を目指して〜 Invited

    河内泉

    日本多発性硬化症協会ニュース・レター   43 ( 7 )   7 - 8   2020.7

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  • シンポジウム9-1. 血管炎・肥厚性硬膜炎における頭痛診療のすべて Invited

    河内泉

    日本頭痛学会誌   47 ( 1 )   104 - 108   2020

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  • 傍腫瘍性神経症候群 (PNS). 免疫・炎症疾患のすべて Invited

    河内泉, 西澤正豊

    日本医師会雑誌   149 ( 2 )   S330 - S333   2020

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  • 開発中の治療と今後の展望. 特集: 免疫性神経疾患update. III. 診断と治療 多発性硬化症 Invited

    河内泉, 小野純花

    日本臨床   78 ( 11 )   1851 - 1861   2020

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  • 多発性硬化症診療の最前線〜患者さんと共に歩む〜 Invited

    河内泉

    月刊 難病と在宅ケア   26 ( 9 )   56 - 60   2020

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  • 【神経疾患と神経障害性疼痛】中枢神経障害による神経障害性疼痛 病態と治療 多発性硬化症・視神経脊髄炎 Invited

    穂苅 万李子, 河内 泉

    Clinical Neuroscience   37 ( 11 )   1332 - 1334   2019.11

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  • 視神経脊髄炎の病態と治療のUP–TO–DATE;アクアポリン4抗体の発見で何が変わったのか? Invited

    河内泉

    神経治療学   36 ( 3 )   217 - 219   2019.11

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    DOI: 10.15082/jsnt.36.3_217

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  • 肥厚性硬膜炎―最近の話題―肥厚性硬膜炎の歴史と概念―新たな診断基準 Invited

    勇亜衣子, 河内泉

    月刊脳神経内科   91 ( 3 )   340‐351 - 351   2019.9

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  • 私の治療 多発性硬化症(MS)・視神経脊髄炎(NMOSD) Invited

    河内泉

    週刊日本医事新報   ( 4967 )   42‐43   2019.7

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  • Charcot’s conceptから見る視神経脊髄炎 Invited

    河内泉

    Bio Clinica   34 ( 5 )   557‐560   2019.5

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  • 多発性硬化症に自己抗体の関与はあるか 病理 Invited

    河内泉

    Clinical Neuroscience   36 ( 11 )   1286‐1290   2018.11

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  • 多発性硬化症診療最前線 再発予防・進行抑制療法 モノクローナル抗体治療 Invited

    河内泉

    Pharma Medica   36 ( 3 )   37‐44   2018.3

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  • NMOとMSの最新情報 NMOのdisease modifying therapy Invited

    河内泉

    脊椎脊髄ジャーナル   30 ( 8 )   765‐773   2017.8

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    DOI: 10.11477/mf.5002200688

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  • 神経内科がわかる,好きになる 今日から実践できる診察・診断・治療のエッセンス 第5章 神経内科の重要疾患~エキスパートはこう診断する!8.多発性硬化症/視神経脊髄炎 Invited

    若杉尚宏, 河内泉

    レジデントノート   18 ( 17 )   3172‐3179   2017.2

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  • 7.脱髄・免疫性疾患 2 多発性硬化症の「炎症・変性」と進行型多発性硬化症に対する治療の最新動向 Invited

    河内泉

    Annual Review 神経   2017   205‐214   2017.1

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  • 多発性硬化症の早期診断と早期治療のUP-TO-DATE Invited

    河内泉, 西澤正豊

    神経治療学(Web)   33 ( 3 )   475‐477(J‐STAGE)   2016

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    DOI: 10.15082/jsnt.33.3_475

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  • 「神経変性」の視点から中枢神経系自己免疫疾患を考える Invited

    河内泉, 西澤正豊

    月刊メディカル・サイエンス・ダイジェスト   41 ( 14 )   541 - 543   2015.12

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  • 臓器特異的自己免疫疾患 免疫性神経・筋疾患 自己免疫性脳炎・脳症 AMPA受容体抗体脳炎 Invited

    河内泉, 西澤正豊

    日本臨床   117 - 120   2015.11

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  • Neuromyelitis optica(NMO)NMOの診断と治療―NMOのあらたな診断基準と治療薬 Invited

    柳村文寛, 河内泉, 西澤正豊

    医学のあゆみ   255 ( 5 )   390 - 396   2015.10

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  • 免疫性中枢神経疾患 視神経脊髄炎(NMO)NMO spectrum disorder Invited

    河内泉, 西澤正豊

    日本臨床   73   289 - 293   2015.9

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  • その他の免疫性神経疾患 自己免疫性脳炎・脳症 AMPA受容体抗体脳炎 Invited

    石黒舞乃, 河内泉, 西澤正豊

    日本臨床   73   626 - 631   2015.9

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  • 自己免疫性脳炎―抗原・抗体は何をしている?アクアポリン アクアポリンと視神経脊髄炎 Invited

    河内泉, 西澤正豊

    Clinical Neuroscience   33 ( 1 )   83 - 87   2015.1

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  • 自己免疫性脳炎―抗原・抗体は何をしている?VGKC VGKC複合体抗体陽性脳炎 Invited

    柳村文寛, 河内泉, 西澤正豊

    Clinical Neuroscience   33 ( 1 )   45 - 48   2015.1

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  • 多発性硬化症のパラダイムシフト―病態から治療まで 検査 神経心理検査 Invited

    河内泉, 西澤正豊

    Clinical Neuroscience   32 ( 11 )   1263 - 1266   2014.11

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  • 多発性硬化症と視神経脊髄炎 III.検査・診断法 神経放射線学的検査(MRI) Invited

    河内泉, 西澤正豊

    日本臨床   72 ( 11 )   1976 - 1982   2014.11

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  • 薬剤師が知っておくべき臓器別画像解析の基礎知識(44)8.神経内科学分野(2)中枢神経系における自己免疫性疾患の画像診断 Invited

    穂苅 万季子, 河内 泉, 西澤 正豊

    医薬ジャーナル   50 ( 8 )   5 - 9   2014.8

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    Other Link: http://search.jamas.or.jp/link/ui/2014354830

  • 薬剤師が知っておくべき臓器別画像解析の基礎知識(43)8.神経内科学分野(1)中枢神経系の炎症性肉芽腫性疾患の画像診断 Invited

    横関 明子, 河内 泉, 西澤 正豊

    医薬ジャーナル   50 ( 7 )   5 - 8   2014.7

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    Other Link: http://search.jamas.or.jp/link/ui/2014311288

  • 多発性硬化症の認知機能障害 多発性硬化症における認知機能障害と神経放射線学的所見 Invited

    河内泉, 西澤正豊

    月刊神経内科   80 ( 5 )   574 - 580   2014.5

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  • 多発性硬化症の新展開 多発性硬化症・視神経脊髄炎における認知機能障害 Invited

    河内泉, 西澤正豊

    脳21   16 ( 4 )   454 - 459   2013.10

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  • 多発性硬化症(MS)と視神経脊髄炎(NMO)の最新情報 MSとNMOの画像解析

    岡本浩一郎, 河内泉, 西澤正豊

    Pharma Medica   31 ( 6 )   27 - 32   2013.6

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  • アクアポリン4抗体 Invited

    西澤正豊, 河内泉

    SRL宝函   32 ( 2 )   4 - 12   2011.7

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  • 自己免疫疾患の病因―疾患ゲノム解析 多発性硬化症のゲノム解析 Invited

    西澤正豊, 河内泉

    医学のあゆみ   230 ( 9 )   616 - 619   2009.8

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  • 1. Approach to Diagnosis Invited

    Kawachi Izumi

    Nihon Naika Gakkai Kaishi   97 ( 8 )   1823 - 1829   2008.8

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    Language:Japanese   Publisher:The Japanese Society of Internal Medicine  

    DOI: 10.2169/naika.97.1823

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    Other Link: http://hdl.handle.net/10191/17985

  • 免疫性神経・筋疾患の動物モデル 多発筋炎 Invited

    河内泉

    アニテックス   19 ( 6 )   24 - 32   2007.10

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  • Experimental allergic myositis (EAM), established as an animal model of polymyositis Invited

    Kawachi I

    Laboratory Animal Technology and Science   19   24 - 32   2007

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  • Paraneoplastic syndrome 多発筋炎の発症機構に関与するT細胞エピトープ Invited

    河内泉, 田中恵子, 辻省次

    医学のあゆみ   201 ( 3 )   197 - 198   2002.4

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  • Recent Advances of Therapeutic Apheresis in Neuroimmunological Diseases. Invited

    河内泉, 田中恵子, 辻省次

    新潟医学会雑誌   116 ( 1 )   1 - 11   2002.1

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    We reviewed recent advances of therapeutic apheresis in neuroimmunological diseases including Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), Miller Fisher syndrome (MFS), Bickerstaff brainstem encephalitis (BBE) and myasthenia gravis (MG). The etiology of GBS and its related disease (CIDP, MFS and BBE) still remains controversial, but important advances have been made in the delineation of the mechanisms that lead to nerve damages. The infecting organisms induce humoral (antiganglioside antibody et. al.) and cellular immune responses that, because of the sharing of homologous epitopes (molecular mimicry), cross-react with ganglioside on the surface of peripheral nerves. Plasma exchange (PE) that removes these pathogenic humoral factors improves the early outcome in GBS. Also, high-dose intra venous immunoglobulin (IVIG), but not steroid therapy, has been shown to be at least as effective as plasma exchange. PE and IVIG carry individual advantages and disadvantages compared with each other. We need establishment of a standard protocol for the therapy of GBS based on clinical and molecular parameters. While PE is a fundamental therapy for GBS, PE can be applied for MG for a rescue therapy to treat the crisis of MG. In MG, extended thymectomy and high-dose corticosteroids therapies, in which symptoms improve after several weeks or months, are essential. Therefore, in myasthenia crisis, when patients necessitate effective therapy immediately, PE can be a rescue treatment with improvement occurring within days of treatment. But the beneficial effect of PE are temporary, lasting only weeks. The purpose of therapeutic apheresis is different from various neuroimmunologic disorders, and in future, based on clinical and molecular mechanism, we should use various treatments (PE, IVIG, corticosteroids, immunosuppressive agents and specific immunotherapy).

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  • 21世紀の神経免疫学 展望 多発筋炎 Invited

    河内泉, 田中恵子, 田中正美, 辻省次

    医学のあゆみ   200 - 204   2001.11

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  • 病因T細胞エピトープと疾患の発症機構 多発筋炎 Invited

    河内泉, 田中恵子, 田中正美, 辻省次

    臨床免疫   35 ( 4 )   437 - 444   2001.4

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  • 傍腫瘍性神経症候群 Invited

    田中 正美, 河内 泉, 田中 恵子

    日本医事新報   ( 3942 )   37 - 41   1999.11

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    Other Link: http://search.jamas.or.jp/link/ui/2000081514

  • Recent advances in HLA research. Peptide motifs and HLA class I superfamily. Invited

    田中正美, 河内泉, 田中恵子

    月刊神経内科   50 ( 2 )   191 - 199   1999.2

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  • 多発性硬化症 (MS), 視神経脊髄炎スペクトラム障害 (NMOSD). 特集 病棟・外来でよくみる気になる神経診療Up to Date Invited

    河内泉

    月刊 薬事   66 ( 4 )   85(741) - 90(746)   2024

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  • 神経領域. 特集: IgG4関連疾患. III. 各論 (診断と治療) Invited

    河内泉

    日本臨床   82 ( 3 )   406 - 412   2024

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  • 多発性硬化症の治療. 特集I 神経免疫疾患-病態から最新治療まで Invited

    河内泉

    脳神経内科   100 ( 1 )   16 - 25   2024

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  • 神経免疫疾患の診断・重症度分類・ガイドラインの妥当性検証・改定と全国調査による患者QOLの改善の検証 第5回全国調査からみた多発性硬化症の重症度に寄与する因子の検討

    磯部紀子, 渡邉充, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 河内泉, 河内泉, 越智博文, 中辻裕司, 福元尚子, 林史恵, 宮崎雄生, 藤盛寿一, 久冨木原健二, 奥野龍禎, 中村優理, 中村優理, 迫田礼子, 米元耕輔, 平良遼志, 野村恭一, 山村隆, 藤原一男, 田中正美, 錫村明生, 清水優子, 清水潤, 園生雅弘, 松尾秀徳, 渡邊修, 深澤俊行, 荻野美恵子, 郡山達男, 斎田孝彦, 野村芳子, 横山和正, 神田隆, 田原将行, 横田隆徳, 大橋高志, 鈴木則宏, 楠進, 栗山長門, 栗山長門, 和泉唯信, 小池春樹, 佐藤泰憲, 三澤園子, 村井弘之, 本村政勝, 吉川弘明, 中西恵美, 中村好一, 中村幸志, 坂田清美, 嶋田莉奈子, 松井真, 桑原聡, 吉良潤一, 吉良潤一, 吉良潤一

    神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証 令和3年度 総括・分担研究報告書(Web)   2022

  • 日本人多発性硬化症患者における認知機能とQOL,疲労,抑うつとの相関

    新野正明, 福元尚子, 奥野龍禎, 三條伸夫, 深浦彦彰, 森雅裕, 大橋高志, 竹内英之, 清水優子, 藤盛寿一, 河内泉, 河内泉, 吉良潤一, 高橋恵里, 宮崎雄生, 三船恒裕

    日本神経学会学術大会プログラム・抄録集   63rd   2022

  • 神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証 第5回多発性硬化症・視神経脊髄炎全国臨床疫学調査結果 第2報

    吉良潤一, 吉良潤一, 磯部紀子, 渡邉充, 松下拓也, 福元尚子, 林史恵, 新野正明, 宮崎雄生, 中島一郎, 藤盛寿一, 酒井康成, 米元耕輔, 平良遼志, 中原仁, 久冨木原健二, 河内泉, 河内泉, 越智博文, 中辻裕司, 奥野龍禎, 中村優理, 中村優理, 迫田礼子, 野村恭一, 山村隆, 藤原一男, 田中正美, 錫村明生, 清水優子, 清水潤, 園生雅弘, 松尾秀徳, 渡邉修, 深澤俊行, 荻野美恵子, 郡山達男, 斎田孝彦, 野村芳子, 横山和正, 神田隆, 田原将行, 横田隆徳, 大橋高志, 鈴木則宏, 楠進, 栗山長門, 和泉唯信, 小池春樹, 佐藤泰憲, 三澤園子, 村井弘之, 本村政勝, 吉川弘明, 中村好一, 中村幸志, 坂田清美, 松井真, 桑原聡

    神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証 令和2年度 総括・分担研究報告書(Web)   2021

  • Continued Increase of Multiple Sclerosis and Neuromyelitis Optica in Japan: Updates from the 5th Nationwide Survey

    Jun-ichi Kira, Noriko Isobe, Masaaki Niino, Takuya Matsushita, Yuri Nakamura, Ichiro Nakashima, Mitsuru Watanabe, Yasunari Sakai, Ayako Sakoda, Jin Nakahara, Izumi Kawachi, Hirofumi Ochi, Yuji Nakatsuji, Yusei Miyazaki, Juichi Fujimori, Kenji Kufukihara, Tatsusada Okuno, Shoko Fukumoto, Fumie Hayashi, Kousuke Yonemoto, Ryoji Taira, Yoshikazu Nakamura, Koshi Nakamura, Kiyomi Sakata, Rinako Shimada, Makoto Matsui

    ANNALS OF NEUROLOGY   88   S199 - S200   2020.10

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  • ANCA関連脊髄肥厚性硬膜炎の臨床免疫病理学的検討

    中島 章博, 佐治 越爾, 清水 宏, 豊島 靖子, 岡本 浩一郎, 若杉 尚宏, 柳村 文寛, 柳川 香織, 柿田 明美, 小野寺 理, 河内 泉

    神経免疫学   25 ( 1 )   134 - 134   2020.10

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  • 進行性腎細胞癌へのニボルマブ・イピリムマブ併用療法後に生じた自己免疫性脳炎の1例

    小林 彩夏, 小出 眞悟, 佐治 越爾, 山名 一寿, 河内 泉, 富田 善彦, 小野寺 理

    神経免疫学   25 ( 1 )   131 - 131   2020.10

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  • 重症筋無力症合併視神経脊髄炎関連疾患の解析

    佐治 越爾, 中島 章博, 若杉 尚宏, 柳川 香織, 小野寺 理, 河内 泉

    神経免疫学   25 ( 1 )   115 - 115   2020.10

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  • 抗GD1aIgM抗体と抗GT1bIgM抗体が陽性で免疫グロブリン療法が奏功した遠位優位型CIDPの76歳男性例

    羽入 龍太郎, 須貝 章弘, 加藤 怜, 秋山 夏葵, 徳武 孝允, 金澤 雅人, 河内 泉, 小野寺 理

    臨床神経学   60 ( 1 )   87 - 87   2020.1

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  • 全脳室および後頭蓋窩拡大を呈した水頭症に対し第3脳室底開窓術を行った42歳男性例

    勇 亜衣子, 中村 航世, 太田 智慶, 柳村 文寛, 畠山 公大, 佐治 越爾, 佐野 正和, 河内 泉, 岡本 浩一郎, 小野寺 理

    神経治療学   36 ( 6 )   S231 - S231   2019.10

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  • 急性脳炎・脳炎 抗GABAB受容体抗体脳炎の臨床的・免疫学的解析

    勇 亜衣子, 坂田 佑輔, 柳村 文寛, 今野 卓哉, 佐治 越爾, 小野寺 理, 河内 泉

    神経免疫学   24 ( 1 )   110 - 110   2019.9

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  • 持続性部分てんかんで発症しfalse lateralizationを認めた抗GAD抗体陽性脳炎成人例

    坂田 佑輔, 佐治 越爾, 永井 貴大, 渡邉 緑, 柴田 健太郎, 他田 正義, 河内 泉, 小野寺 理

    てんかん研究   37 ( 2 )   679 - 679   2019.9

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  • 視神経脊髄炎の病変局所における炎症極性の解析

    柳村 文寛, 佐治 越爾, 若杉 尚宏, 穂苅 万李子, 柳川 香織, 豊島 靖子, 高橋 均, 柿田 明美, 小野寺 理, 河内 泉

    神経免疫学   24 ( 1 )   131 - 131   2019.9

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  • 本邦における高齢発症視神経脊髄炎の臨床免疫学的特徴 連続73症例の解析から

    中島 章博, 佐治 越爾, 若杉 尚宏, 柳村 文寛, 柳川 香織, 穂苅 万李子, 小野寺 理, 河内 泉

    神経免疫学   24 ( 1 )   144 - 144   2019.9

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  • 多発性硬化症および視神経脊髄炎患者の臨床的特徴 過去28年間における変遷

    佐治 越爾, 中島 章博, 若杉 尚宏, 柳村 文寛, 柳川 香織, 穂苅 万李子, 小野寺 理, 河内 泉

    神経免疫学   24 ( 1 )   144 - 144   2019.9

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  • MS/NMO1 多発性硬化症における認知機能障害と頭部MRIを用いたVBM解析

    若杉 尚宏, 佐治 越爾, 柳村 文寛, 穂苅 万李子, 柳川 香織, 小野寺 理, 河内 泉

    神経免疫学   24 ( 1 )   106 - 106   2019.9

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  • 持続性部分てんかんで発症しfalse lateralizationを認めた抗GAD抗体陽性脳炎成人例

    坂田 佑輔, 佐治 越爾, 永井 貴大, 渡邉 緑, 柴田 健太郎, 他田 正義, 河内 泉, 小野寺 理

    てんかん研究   37 ( 2 )   679 - 679   2019.9

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  • Efficacy of dimethyl fumarate in Japanese multiple sclerosis patients: interim analysis of randomized, double-blind APEX study and its open-label extension. Reviewed

    Kondo T, Kawachi I, Onizuka Y, Hiramatsu K, Hase M, Yun J, Matta A, Torii S

    Mult Scler J Exp Transl Clin.   5 ( 3 )   2055217319864974 - 205521731986497   2019.7

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  • 眼筋症状のみで経過し、発症から8年後に初めて球麻痺症状を呈した抗MuSK抗体陽性重症筋無力症の76歳女性

    北原 匠, 上村 昌寛, 熊谷 航一郎, 柳村 文寛, 中村 航世, 茂木 崇秀, 河内 泉, 小野寺 理

    臨床神経学   59 ( 5 )   305 - 305   2019.5

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  • 高度の記憶障害と歩行障害を呈し、治療により劇的に改善した抗GABAB受容体抗体脳炎の60歳男性例

    坂田 佑輔, 今野 卓哉, 五十嵐 一也, 浦部 陽香, 徳武 孝允, 野嵜 幸一郎, 河内 泉, 小野寺 理

    臨床神経学   59 ( 4 )   220 - 220   2019.4

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  • Radiological, immunological, and pathological analysis of ependymal cells in neuromyelitis spectrum disorders

    Fumihiro Yanagimura, Etsuji Saji, Takahiro Wakasugi, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Osamu Onodera, Izumi Kawachi

    BRAIN PATHOLOGY   29   134 - 134   2019.2

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  • 高度の記憶障害と歩行障害を呈し,治療により劇的に改善した抗GABA<sub>B</sub>受容体抗体脳炎の60歳男性例

    坂田佑輔, 今野卓哉, 五十嵐一也, 浦部陽香, 徳武孝允, 野嵜幸一郎, 河内泉, 小野寺理

    臨床神経学(Web)   59 ( 4 )   2019

  • 難治性疾患の継続的な疫学データの収集・解析に関する研究 多発性硬化症・視神経脊髄炎関連疾患に関する研究

    中村好一, 坂田清美, 中村幸志, 玉腰暁子, 吉良潤一, 中村優理, 磯部紀子, 酒井康成, 新野正明, 越智博文, 中島一郎, 河内泉, 中原仁, 中辻裕司, 松井真

    難治性疾患の継続的な疫学データの収集・解析に関する研究 平成30年度 総括・分担研究報告書(Web)   2019

  • COX10変異とPMP22欠失を伴った白質脳症の一家系 分子遺伝学的解析

    石黒 敬信, 黒羽 泰子, 原 範和, 目崎 直実, 三浦 健, 春日 健作, 長谷川 有香, 谷 卓, 高橋 哲哉, 松原 奈絵, 他田 真理, 河内 泉, 柿田 明美, 小野寺 理, 小池 亮子, 池内 健

    臨床神経学   58 ( Suppl. )   S327 - S327   2018.12

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  • COX10変異とPMP22欠失を伴った白質脳症の一家系 臨床病理学的解析

    黒羽 泰子, 石黒 敬信, 長谷川 有香, 谷 卓, 高橋 哲哉, 松原 奈絵, 他田 真理, 河内 泉, 柿田 明美, 小野寺 理, 池内 健, 小池 亮子

    臨床神経学   58 ( Suppl. )   S327 - S327   2018.12

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  • 病理学的に同定した進行性の白質病変を認めた脳アミロイドβ関連血管炎の2症例

    北原 匠, 上村 昌博, 柳村 文博, 畠野 雄也, 須貝 章弘, 河内 泉, 柿田 明美, 小野寺 理

    Dementia Japan   32 ( 3 )   482 - 482   2018.9

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  • 急性脳炎・脳症 Cortical midline structuresを主病変とする抗GAD抗体関連自己免疫性脳炎の1例

    坂田 佑輔, 佐治 越爾, 永井 貴大, 渡邉 緑, 柴田 健太郎, 他田 正義, 河内 泉, 小野寺 理

    神経免疫学   23 ( 1 )   97 - 97   2018.9

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  • MS/NMO 視神経脊髄炎におけるmelanoma cell adhesion moleculeの病理学的検討

    柳村 文寛, 佐治 越爾, 若杉 尚宏, 穂苅 万李子, 柳川 香織, 豊島 靖子, 柿田 明美, 高橋 均, 小野寺 理, 河内 泉

    神経免疫学   23 ( 1 )   93 - 93   2018.9

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  • 多発性硬化症の縦断的認知機能動態とQOLの解析

    若杉 尚宏, 佐治 越爾, 柳村 文寛, 穂苅 万李子, 柳川 香織, 小野寺 理, 河内 泉

    神経免疫学   23 ( 1 )   130 - 130   2018.9

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  • 視神経脊髄炎関連疾患におけるジェンダー効果の解析

    佐治 越爾, 中島 章博, 若杉 尚宏, 柳村 文寛, 柳川 香織, 小野寺 理, 河内 泉

    神経免疫学   23 ( 1 )   129 - 129   2018.9

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  • 自己免疫性脳炎 Neuromyelitis opticaにおけるTRPM4分子発現動態の解析

    穂苅 万李子, 佐治 越爾, 柳村 文寛, 若杉 尚宏, 柳川 香織, 豊島 靖子, 柿田 明美, 小野寺 理, 西澤 正豊, 河内 泉

    神経免疫学   23 ( 1 )   87 - 87   2018.9

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  • T2*強調画像で微小出血を認めず、軟髄膜病変が急速に拡大したアミロイドβ関連血管炎の75歳女性例

    畠野 雄也, 須貝 章弘, 山岸 拓磨, 中島 章博, 他田 正義, 河内 泉, 小野寺 理

    臨床神経学   58 ( 8 )   529 - 529   2018.8

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  • 三叉神経節から脊髄路核までMRIで造影効果を伴う病変を認め、バラシクロビルが奏功した38歳男性例

    加藤 怜, 須貝 章弘, 山岸 拓磨, 他田 正義, 河内 泉, 小野寺 理

    臨床神経学   58 ( 4 )   253 - 253   2018.4

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  • T2<sup>*</sup>強調画像で微小出血を認めず,軟髄膜病変が急速に拡大したアミロイドβ関連血管炎の75歳女性例

    畠野雄也, 須貝章弘, 山岸宅磨, 中島章博, 他田正義, 河内泉, 小野寺理

    臨床神経学(Web)   58 ( 8 )   2018

  • 有痛性筋痙攣に対して免疫グロブリン静注療法が有効であった筋萎縮性側索硬化症の1例

    茂木 崇秀, 石原 智彦, 他田 正義, 河内 泉, 下畑 享良, 小野寺 理

    神経治療学   34 ( 6 )   S199 - S199   2017.11

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  • MSのより良い臨床治療に関するReal World Question(RWQ)(Real World Question(RWQ) for Better Practical MS Treatment)

    河内 泉, 中島 一郎, 野原 千洋子, 宮本 勝一, 横山 和正

    神経免疫学   22 ( 1 )   77 - 77   2017.10

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  • 肥厚性硬膜炎・自己免疫疾患・膠原病 診断基準・重症度分類作成に向けた肥厚性硬膜炎の臨床的・免疫学的解析

    佐治 越爾, 横関 明子, 若杉 尚宏, 柳村 文寛, 穂苅 万李子, 柳川 香織, 西澤 正豊, 小野寺 理, 河内 泉

    神経免疫学   22 ( 1 )   89 - 89   2017.10

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  • 急性脳炎・脳症 自己免疫性脳炎の臨床的・免疫学的・放射線学的特徴の解析

    若杉 尚宏, 佐治 越爾, 柳村 文寛, 穂苅 万李子, 柳川 香織, 西澤 正豊, 小野寺 理, 河内 泉

    神経免疫学   22 ( 1 )   102 - 102   2017.10

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  • 臨床ケース 再発性胸腺腫術後に腹壁の難治性疼痛を呈した重症筋無力症の44歳男性例

    山岸 拓磨, 佐治 越爾, 荻根沢 真也, 安藤 昭一郎, 茂木 崇秀, 他田 正義, 河内 泉, 小野寺 理

    神経免疫学   22 ( 1 )   106 - 106   2017.10

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  • MS・NMO2 視神経脊髄炎における脳室上衣の免疫学的・病理学的検討

    柳村 文寛, 佐治 越爾, 穂苅 万李子, 若杉 尚宏, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊, 小野寺 理, 河内 泉

    神経免疫学   22 ( 1 )   113 - 113   2017.10

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  • 急性脳炎・脳症 自己免疫性脳炎の臨床的・免疫学的・放射線学的特徴の解析

    若杉 尚宏, 佐治 越爾, 柳村 文寛, 穂苅 万李子, 柳川 香織, 西澤 正豊, 小野寺 理, 河内 泉

    神経免疫学   22 ( 1 )   102 - 102   2017.10

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  • 臨床ケース 再発性胸腺腫術後に腹壁の難治性疼痛を呈した重症筋無力症の44歳男性例

    山岸 拓磨, 佐治 越爾, 荻根沢 真也, 安藤 昭一郎, 茂木 崇秀, 他田 正義, 河内 泉, 小野寺 理

    神経免疫学   22 ( 1 )   106 - 106   2017.10

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  • MS・NMO2 視神経脊髄炎における脳室上衣の免疫学的・病理学的検討

    柳村 文寛, 佐治 越爾, 穂苅 万李子, 若杉 尚宏, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊, 小野寺 理, 河内 泉

    神経免疫学   22 ( 1 )   113 - 113   2017.10

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  • 肥厚性硬膜炎・自己免疫疾患・膠原病 診断基準・重症度分類作成に向けた肥厚性硬膜炎の臨床的・免疫学的解析

    佐治 越爾, 横関 明子, 若杉 尚宏, 柳村 文寛, 穂苅 万李子, 柳川 香織, 西澤 正豊, 小野寺 理, 河内 泉

    神経免疫学   22 ( 1 )   89 - 89   2017.10

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  • Dynamics of tissue regulatory T cells in neuromyelitis optica spectrum disorders lesions

    F. Yanagimura, E. Saji, T. Wakasugi, M. Hokari, Y. Toyoshima, A. Kakita, H. Takahashi, M. Nishizawa, O. Onodera, I. Kawachi

    MULTIPLE SCLEROSIS JOURNAL   23   492 - 492   2017.10

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  • Double inversion recovery MRI in the evaluation of the anterior visual pathway in patients with multiple sclerosis and neuromyelitis optica spectrum disorders

    E. Saji, M. Hokari, A. Yokoseki, T. Wakasugi, F. Yanagimura, K. Yanagawa, M. Nishizawa, O. Onodera, I. Kawachi

    MULTIPLE SCLEROSIS JOURNAL   23   102 - 102   2017.10

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  • 単下肢失調を呈した多発性硬化症の30歳女性例

    井上 佳奈, 大原 浩司, 茂木 崇秀, 佐治 越爾, 他田 正義, 河内 泉, 下畑 享良, 小野寺 理

    臨床神経学   57 ( 6 )   335 - 335   2017.6

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  • RECOMMENDATIONS FOR THE MANAGEMENT OF NEURO-BEHET DISEASE BY JAPANESE RESEARCH COMMITTEE FOR BEHET DISEASE

    H. Kikuchi, T. Sawada, M. Okada, M. Takeno, M. Kuwana, Y. Ishigatsubo, I. Kawachi, H. Mochizuki, S. Kusunoki, S. Hirohata

    ANNALS OF THE RHEUMATIC DISEASES   76   610 - 611   2017.6

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    DOI: 10.1136/annrheumdis-2017-eular.1201

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  • Axo-glial Pathology of Anterior Visual Pathways in NMO

    Izumi Kawachi

    MULTIPLE SCLEROSIS JOURNAL   23 ( 2 )   309 - 309   2017.2

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  • The 3rd MS Summer College in Kobe (6–7 August 2016)Practical issues and new horizons in MS, NMOSD and related disorders

    Etsuji Saji, Izumi Kawachi

    Clinical and Experimental Neuroimmunology   8   58 - 62   2017.1

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    DOI: 10.1111/cen3.12355

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究班

    神田隆, 松井真, 渡邊修, 米田誠, 犬塚貴, 栗山長門, 池田修一, 荻野美恵子, 梶龍兒, 久保田龍二, 清水優子, 鈴木則宏, 河内泉, 野村恭一, 原寿郎, 横田隆徳, 中村龍文, 野村芳子, 山野嘉久, 玉越暁子, 大石真莉子, 古賀道明, 田中恵子, 中村好一

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 平成28年度 総括・分担研究報告書(Web)   31‐32 (WEB ONLY)   2017

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 多発性硬化症患者重症度の評価法の比較検討

    松井真, 河合宇吉郎, 内田信彰, 楠進, 桑原聡, 森雅裕, 清水潤, 清水優子, 園生雅弘, 田中正美, 中辻裕司, 新野正明, 河内泉, 野村恭一, 藤原一男, 松尾秀徳, 渡邊修

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 平成28年度 総括・分担研究報告書(Web)   19‐20 (WEB ONLY)   2017

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 肥厚性硬膜炎の診断基準・重症度分類に関する研究

    河内泉, 西澤正豊, 佐治越爾, 横関明子, 柳村文寛, 若杉尚宏, 荒川武蔵, 柳川香織, 穂苅万李子, 小野寺理, 豊島靖子, 柿田明美, 高橋均

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 平成28年度 総括・分担研究報告書(Web)   50‐51 (WEB ONLY)   2017

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 多発性硬化症と視神経脊髄炎の臨床経過と炎症・神経変性機構に関する研究

    河内泉, 穂苅万李子, 佐治越爾, 柳村文寛, 若杉尚宏, 横関明子, 荒川武蔵, 柳川香織, 小野寺理, 豊島靖子, 柿田明美, 高橋均, 西澤正豊

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 平成28年度 総括・分担研究報告書(Web)   39‐40 (WEB ONLY)   2017

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  • 視神経脊髄炎におけるtissue Tregs動態の検討

    柳村 文寛, 佐治 越爾, 穂苅 万李子, 柳川 香織, 豊島 靖子, 柿田 明美, 高橋 均, 小野寺 理, 西澤 正豊, 河内 泉

    神経免疫学   21 ( 1 )   123 - 123   2016.9

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  • 視神経脊髄炎におけるtissue Tregs動態の検討

    柳村 文寛, 佐治 越爾, 穂苅 万李子, 柳川 香織, 豊島 靖子, 柿田 明美, 高橋 均, 小野寺 理, 西澤 正豊, 河内 泉

    神経免疫学   21 ( 1 )   123 - 123   2016.9

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  • Neuromyelitis optica脳病変における神経放射線学的・神経病理学的特徴

    穂苅 万李子, 佐治 越爾, 柳村 文寛, 柳川 香織, 豊島 靖子, 柿田 明美, 高橋 均, 小野寺 理, 西澤 正豊, 河内 泉

    神経免疫学   21 ( 1 )   124 - 124   2016.9

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  • 眼窩炎症性偽腫瘍における髄液サイトカイン・ケモカインの検討

    佐治 越爾, 西田 茉那, 柳村 文寛, 穂苅 万李子, 若杉 尚宏, 柳川 香織, 小野寺 理, 西澤 正豊, 河内 泉

    神経免疫学   21 ( 1 )   139 - 139   2016.9

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  • 重症帯状疱疹のためフィンゴリモド一時中断に伴いbreakthrough disease様の進展を来した多発性硬化症の一例

    大津 裕, 佐治 越爾, 柳村 文寛, 穂苅 万李子, 若杉 尚宏, 柳川 香織, 西澤 正豊, 河内 泉, 小野寺 理

    神経免疫学   21 ( 1 )   108 - 108   2016.9

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  • 神経免疫学会はいかに若手を育て、共に成長していくか いかに若手を育て、共に成長していくか 新潟大学脳研究所神経免疫チームの取り組み

    佐治 越爾, 河内 泉

    神経免疫学   21 ( 1 )   75 - 75   2016.9

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  • Severe neurodegeneration and unique dynamics of aquaporin-4 on astrocytes in the anterior visual pathway of neuromyelitis optica.

    I. Kawachi, M. Hokari, A. Yokoseki, M. Arakawa, E. Saji, K. Yanagawa, F. Yanagimura, Y. Toyoshima, A. Kakita, H. Takahashi, O. Onodera, M. Nishizawa

    MULTIPLE SCLEROSIS JOURNAL   22   24 - 24   2016.9

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  • 中枢神経系炎症性脱髄疾患における自己免疫現象とミトコンドリア動態異常を伴う神経変性

    河内泉

    月刊メディカル・サイエンス・ダイジェスト   42 ( 8 )   357‐359   2016.7

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 視神経脊髄炎と多発性硬化症における前部視覚路障害の臨床的特徴

    西澤正豊, 穂苅万李子, 河内泉, 横関明子, 佐治越爾, 荒川武蔵, 柳川香織, 柳村文寛, 豊島靖子, 柿田明美, 高橋均

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 平成27年度 総括・分担研究報告書   81‐82   2016

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 視神経脊髄炎と多発性硬化症におけるグリア異常を介した神経変性機構の解析

    西澤正豊, 河内泉, 穂苅万李子, 横関明子, 佐治越爾, 荒川武蔵, 柳川香織, 柳村文寛, 豊島靖子, 柿田明美, 高橋均

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 平成27年度 総括・分担研究報告書   46‐47   2016

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  • 神経Behcet's病の脳脊髄液サイトカイン・ケモカインの解析

    柳村 文寛, 佐治 越爾, 穂苅 万李子, 柳川 香織, 横関 明子, 西澤 正豊, 河内 泉

    神経免疫学   20 ( 1 )   116 - 116   2015.9

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  • 脳炎・その他 炎症性脱髄病変の併発が疑われたT3271C変異MELASの一例

    石黒 舞乃, 佐治 越爾, 矢島 隆二, 樋口 陽, 石川 正典, 関根 有美, 下畑 享良, 西澤 正豊, 河内 泉

    神経免疫学   20 ( 1 )   108 - 108   2015.9

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  • NMO臨床 視神経脊髄炎における抗ミトコンドリア抗体の検討

    穂苅 万李子, 佐治 越爾, 柳村 文寛, 柳川 香織, 横関 明子, 西澤 正豊, 河内 泉

    神経免疫学   20 ( 1 )   85 - 85   2015.9

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  • 炎症性脱髄病変の併発が疑われたT3271C変異MELASの一例

    石黒 舞乃, 佐治 越爾, 矢島 隆二, 樋口 陽, 石川 正典, 関根 有美, 下畑 享良, 西澤 正豊, 河内 泉

    神経免疫学   20 ( 1 )   135 - 135   2015.9

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  • 11 緩徐に進行する小脳症状を呈した54歳女性例(Ⅰ.一般演題, 第55回下越内科集談会)

    129 ( 5 )   292 - 292   2015.5

  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 視神経脊髄炎と多発性硬化症における神経変性機構の解析

    西澤正豊, 河内泉, 穂苅万李子, 佐治越爾, 横関明子, 荒川武蔵, 柳川香織, 豊島靖子, 柿田明美, 高橋均

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 平成26年度 総括・分担研究報告書   72‐73   2015

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  • レセプトデータを活用した我が国の多発性硬化症の治療実態及び医療費分析

    荻野美恵子, 河内泉, 河内泉, 大竹一嘉, 太田浩之, 大塚裕次郎, 岩崎宏介, 廣居伸蔵

    Neuroimmunology   20 ( 1 )   86   2015

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  • 希少性難治性疾患―神経・筋難病疾患の進行抑制治療効果を得るための新たな医療機器,生体電位等で随意コントロールされた下肢装着型補助ロボット(HAL‐HN01)に関する医師主導治験の実施研究 多発性硬化症・視神経脊髄炎における身体・認知機能障害の研究―下肢装着型補助ロボットHAL応用の可能性

    河内泉, 西澤正豊, 穂苅万李子, 柳川香織

    希少性難治性疾患‐神経・筋難病疾患の進行抑制治療効果を得るための新たな医療機器、生体電位等で随意コントロールされた下肢装着型補助ロボット(HAL-HN01)に関する医師主導治験の実施研究 平成26年度 総括・分担研究報告書   56‐59   2015

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  • 多彩な臨床像と画像所見を呈する抗アクアポリン4抗体関連疾患

    梅田麻衣子, 梅田能生, 笠原壮, 今野卓哉, 柳村文寛, 河内泉, 小宅睦郎, 藤田信也

    日本神経学会学術大会プログラム・抄録集   56th ( Suppl. )   511 - S380   2015

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 免疫介在性肥厚性硬膜炎の原因とその位置づけ

    西澤正豊, 河内泉, 穂苅万李子, 佐治越爾, 横関明子, 荒川武蔵, 柳川香織, 豊島靖子, 柿田明美, 高橋均

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究 平成26年度 総括・分担研究報告書   101‐102   2015

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  • 医師主導治験の実施支援並びに我が国の治験推進に関する研究 治験の実施に関する研究[サリドマイド]

    西澤正豊, 河内泉, 小澤鉄太郎

    医師主導治験の実施支援並びに我が国の治験推進に関する研究 平成26年度 総括研究報告書集   12   2015

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  • 緩徐に進行する小脳症状を呈した54歳女性例

    坪口晋太朗, 矢島隆二, 樋口陽, 石川正典, 河内泉, 小山諭, 西澤正豊

    臨床神経学(Web)   55 ( 1 )   2015

  • 抗アクアポリン4抗体陽性視神経炎の視野障害パターンの検討

    山上 明子, 井上 賢治, 若倉 雅登, 高橋 利幸, 河内 泉, 田中 惠子

    神経眼科   31 ( 増補1 )   70 - 70   2014.11

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  • Role of meningeal lymphoid follicle-like structures in the CNS inflammatory disorders

    Izumi Kawachi, Mariko Hokari, Etsuji Saji, Yasuko Toyoshima, Akiko Yokoseki, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizaw

    JOURNAL OF NEUROIMMUNOLOGY   275 ( 1-2 )   64 - 64   2014.10

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    DOI: 10.1016/j.jneuroim.2014.08.169

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  • Clinical and radiological profiles of anterior visual pathway involvement in neuromyelitis optica

    I. Kawachi, A. Yokoseki, E. Saji, M. Hokari, K. Yanagawa, M. Nishizawa

    MULTIPLE SCLEROSIS JOURNAL   20   349 - 350   2014.9

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  • 当院で経験した抗アクアポリン4抗体関連疾患の臨床像と画像所見の検討

    梅田 麻衣子, 柳村 文寛, 笠原 壮, 今野 卓哉, 梅田 能生, 小宅 睦郎, 河内 泉, 藤田 信也

    神経免疫学   19 ( 1 )   137 - 137   2014.9

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  • 中枢神経系におけるリンパ濾胞構造と自己免疫病態の解析

    穂苅 万季子, 河内 泉, 横関 明子, 佐治 越爾, 柳川 香織, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊

    神経免疫学   19 ( 1 )   136 - 136   2014.9

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  • ステロイド治療中に再発した抗アクアポリン4抗体陽性視神経炎の1例

    植木智志, 畑瀬哲尚, 福地健郎, 河内泉

    眼科臨床紀要   7 ( 6 )   473 - 474   2014.6

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  • 12 原発性胆汁性肝硬変の経過中に筋炎・II型呼吸不全・不整脈を呈した1例(一般演題, 第54回下越内科集談会)

    128 ( 6 )   281 - 281   2014.6

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  • Neuromyelitis Optica with Severe Progressive Cognitive and Psychiatric Impairment: Pathological Analysis of Three Autopsied Cases

    Musashi Arakawa, Etsuji Saji, Yasuko Toyoshima, Mariko Hokari, Akiko Yokoseki, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    MULTIPLE SCLEROSIS JOURNAL   20 ( 7 )   945 - 946   2014.6

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  • Optic Perineuritis-like Lesions in Neuromyelitis Optica: Radiological Assessments

    Akiko Yokoseki, Etsuji Saji, Musashi Arakawa, Mariko Hokari, Masatoyo Nishizawa, Izumi Kawachi

    MULTIPLE SCLEROSIS JOURNAL   20 ( 7 )   940 - 940   2014.6

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  • Clinical Profiles of Elderly Patients with ADEM in A Japanese Cohort

    Mariko Hokari, Etsuji Saji, Akiko Yokoseki, Musashi Arakawa, Masatoyo Nishizawa, Izumi Kawachi

    MULTIPLE SCLEROSIS JOURNAL   20 ( 7 )   948 - 948   2014.6

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  • Paraneoplastic Anti-NMDA Receptor Encephalitis Presenting With Neuromyelitis Optica-Like Relapses

    Fumihiro Yanagimura, Izumi Kawachi, Estuji Saji, Mariko Hokari, Akiko Yokoseki, Musashi Arakawa, Masatoyo Nishizawa

    MULTIPLE SCLEROSIS JOURNAL   20 ( 7 )   943 - 944   2014.6

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  • Radiological and Pathological Analyses of Cortical Lesions in Inflammatory Demyelinating Diseases of the Central Nervous System

    Etsuji Saji, Musashi Arakawa, Akiko Yokoseki, Mariko Hokari, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    MULTIPLE SCLEROSIS JOURNAL   20 ( 7 )   940 - 941   2014.6

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  • 腫瘍随伴症候群によるII型呼吸不全で発症した胸腺癌の1例

    佐藤 健, 木村 夕香, 宮尾 浩美, 黒羽 泰子, 小池 亮子, 斎藤 泰晴, 大平 徹郎, 朝川 勝明, 三浦 理, 茂呂 寛, 各務 博, 若杉 尚宏, 金澤 雅人, 河内 泉, 西澤 正豊

    新潟医学会雑誌   128 ( 6 )   280 - 280   2014.6

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  • 免疫性神経疾患に関する調査研究 多発性硬化症/視神経脊髄炎 治療 多発性硬化症のfingolimod治療~CCR7発現サブセットの解析~

    西澤正豊, 横関明子, 河内泉, 佐治越爾, 穂苅万李子, 荒川武蔵

    免疫性神経疾患に関する調査研究 平成25年度 総括・分担研究報告書   30 - 31   2014

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  • 免疫性神経疾患に関する調査研究 多発性硬化症/視神経脊髄炎 病態(1)中枢神経系自己免疫炎症における髄膜リンパ濾胞構造の解析~髄膜形態からみた視神経脊髄炎と多発性硬化症の免疫病態の相違点~

    西澤正豊, 河内泉, 佐治越爾, 穂苅万李子, 横関明子, 荒川武蔵, 豊島靖子, 柿田明美, 高橋均

    免疫性神経疾患に関する調査研究 平成25年度 総括・分担研究報告書   18 - 19   2014

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  • 中枢神経系炎症性脱髄疾患の大脳皮質病変の検討

    荒川 武蔵, 河内 泉, 豊島 靖子, 佐治 越爾, 横関 明子, 穂苅 万李子, 柿田 明美, 高橋 均, 西澤 正豊

    臨床神経学   53 ( 12 )   1462 - 1462   2013.12

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  • 骨格筋病理像からみた「原発性胆汁性肝硬変に関連した筋炎」の位置づけの検討

    穂苅 万李子, 河内 泉, 佐治 越爾, 荒川 武蔵, 横関 明子, 豊島 靖子, 山田 光則, 西澤 正豊

    臨床神経学   53 ( 12 )   1537 - 1537   2013.12

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  • 本邦の多発性硬化症における大脳皮質病変の放射線学的検討

    河内 泉, 荒川 武蔵, 佐治 越爾, 穂苅 万李子, 横関 明子, 西澤 正豊

    臨床神経学   53 ( 12 )   1472 - 1472   2013.12

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  • 本邦における中枢神経系炎症性脱髄疾患の認知機能障害の特徴

    佐治 越爾, 河内 泉, 荒川 武蔵, 穂苅 万李子, 横関 明子, 豊島 靖子, 赤澤 宏平, 柿田 明美, 高橋 均, 西澤 正豊

    臨床神経学   53 ( 12 )   1627 - 1627   2013.12

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  • Fingolimod治療による多発性硬化症患者のリンパ球動態変化の解析

    横関 明子, 河内 泉, 佐治 越爾, 穂苅 万李子, 荒川 武蔵, 西澤 正豊

    臨床神経学   53 ( 12 )   1569 - 1569   2013.12

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  • ANCA関連肥厚性硬膜炎の臨床病理学的特徴

    横関 明子, 河内 泉, 佐治 越爾, 荒川 武蔵, 穂苅 万李子, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊

    神経免疫学   18 ( 1 )   117 - 117   2013.11

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  • Neuromyelitis opticaの中枢神経組織と末梢血における形質芽細胞動態の解析

    荒川 武蔵, 河内 泉, 佐治 越爾, 横関 明子, 穂苅 万李子, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊

    神経免疫学   18 ( 1 )   91 - 91   2013.11

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  • 本邦の中枢神経系脱髄疾患の大脳皮質病変の検出に3D Double Inversion Recovery法は有用である

    佐治 越爾, 河内 泉, 荒川 武蔵, 横関 明子, 穂苅 万李子, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊

    神経免疫学   18 ( 1 )   128 - 128   2013.11

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  • 抗アクアポリン4抗体陽性視神経炎の視神経MRI画像及び視機能障害の検討

    渡辺 敏樹, 気賀沢 一輝, 大原 有紗, 河内 泉, 高橋 利幸, 田中 惠子, 平形 明人

    神経眼科   30 ( 増補1 )   54 - 54   2013.10

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  • FDG-PET/CT、ガリウムシンチグラフィーで全身の骨格筋に著明な集積が認められたサルコイドーシスの一例

    大坪 亜矢, 須藤 真則, 佐藤 弘恵, 中枝 武司, 和田 庸子, 村上 修一, 森山 寛史, 石黒 卓朗, 黒田 毅, 中野 正明, 矢島 隆二, 酒井 奈保子, 石原 智彦, 河内 泉, 西澤 正豊, 成田 一衛, 鈴木 栄一

    日本サルコイドーシス/肉芽腫性疾患学会雑誌   33 ( サプリメント号 )   60 - 60   2013.10

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  • CNS pathology in neuromyelitis optica: region-dependent dynamics of aquaporin-4

    M. Arakawa, E. Saji, Y. Toyoshima, M. Hokari, A. Yokoseki, A. Kakita, H. Takahashi, M. Nishizawa, I. Kawachi

    MULTIPLE SCLEROSIS JOURNAL   19 ( 11 )   330 - 331   2013.10

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  • Cortical degeneration in neuromyelitis optica: Potential pathogenesis of cognitive impairment

    Etsuji Saji, Masatoyo Nishizawa, Izumi Kawachi

    Clinical and Experimental Neuroimmunology   4 ( 2 )   162   2013.8

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    DOI: 10.1111/cen3.12041

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  • 心機能障害を合併した抗ミトコンドリア抗体陽性筋炎の51歳男性例 Reviewed

    笠見 卓哉, 石原 智彦, 柳村 文寛, 穂苅 万李子, 河内 泉, 下畑 享良, 西澤 正豊

    新潟医学会雑誌   127 ( 7 )   388 - 389   2013.7

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  • Role of subarachnoid space as the initiating site for triggering the immune-mediated injury in demyelinating diseases

    Izumi Kawachi

    MULTIPLE SCLEROSIS JOURNAL   19 ( 5 )   649 - 649   2013.4

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  • Anti-NMDA Receptor Encephalitis in the Elderly Associates with Delays in Diagnosis, Treatment, and Worse Clinical outcome

    Maarten Titulaer, Lindsey McCracken, Inigo Gabilondo, Takahiro Iizuka, Izumi Kawachi, Myrna Rosenfeld, Rita Balice-Gordon, Francesc Graus, Josep Dalmau

    NEUROLOGY   80   2013.2

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  • 免疫性神経疾患に関する調査研究 多発性硬化症/視神経脊髄炎 臨床(2)Neuromyelitis opticaの大脳皮質病理に関する検討

    西澤正豊, 河内泉, 荒川武蔵, 佐治越爾, 横関明子, 穂苅万李子, 豊島靖子, 柿田明美, 高橋均

    免疫性神経疾患に関する調査研究 平成24年度 総括・分担研究報告書   19 - 20   2013

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  • 免疫性神経疾患に関する調査研究 多発性硬化症/視神経脊髄炎 臨床(1)日本人多発性硬化症におけるBrief Repeatable Battery of Neuopsychological Tests in Multiple Sclerosis(BRB‐N)を用いた高次脳機能検査,並びにアパシー,疲労,うつとの関連

    新野正明, 三船恒裕, 郡山達男, 森雅裕, 大橋高志, 河内泉, 清水優子, 深浦彦彰, 中島一郎, 宮本勝一, 楠進, 吉田一人, 神田隆, 野村恭一, 山村隆, 吉井文均, 吉良潤一, 中根俊成, 横山和正, 松井真, 宮崎雄生, 菊地誠志

    免疫性神経疾患に関する調査研究 平成24年度 総括・分担研究報告書   7 - 8   2013

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  • 免疫性神経疾患に関する調査研究 多発性硬化症/視神経脊髄炎 臨床(1)本邦の中枢性炎症性脱髄疾患における認知機能障害の特徴

    西澤正豊, 佐治越爾, 河内泉, 荒川武蔵, 横関明子, 穂苅万李子, 豊島靖子, 柿田明美, 高橋均

    免疫性神経疾患に関する調査研究 平成24年度 総括・分担研究報告書   9 - 10   2013

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  • MRSとDTIを用いたNMO患者のNormal appearing gray matterの解析

    眞島 卓弥, 五十嵐 博中, 佐治 越爾, 河内 泉, 西澤 正豊, 中田 力

    臨床神経学   52 ( 12 )   1522 - 1522   2012.12

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  • Potential role of CCR6+T cells in inflammatory demyelinating diseases of central nervous system

    Etsuji Saji, Musashi Arakawa, Mariko Hokari, Yasuko Toyosima, Kaori Yanagawa, Akiko Yokoseki, Akiyoshi Kakita, Hitsohi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    JOURNAL OF NEUROIMMUNOLOGY   253 ( 1-2 )   76 - 77   2012.12

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  • 原発性胆汁性肝硬変に関連した筋炎における臓器障害の検討

    穂苅 万李子, 河内 泉, 佐治 越爾, 荒川 武蔵, 柳川 香織, 豊島 靖子, 山田 光則, 松原 奈絵, 山際 訓, 西澤 正豊

    臨床神経学   52 ( 12 )   1471 - 1471   2012.12

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  • 中枢神経系炎症性脱髄疾患におけるCCR6陽性T細胞の解析

    佐治 越爾, 河内 泉, 荒川 武蔵, 柳川 香織, 横関 明子, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊

    臨床神経学   52 ( 12 )   1399 - 1399   2012.12

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  • Neuromyelitis opticaにおける2010年にMcDonald診断基準の適応と問題点

    柳川 香織, 河内 泉, 佐治 越爾, 荒川 武蔵, 横関 明子, 西澤 正豊

    臨床神経学   52 ( 12 )   1481 - 1481   2012.12

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  • 炎症性筋疾患におけるinnate T細胞の解析

    荒川 武蔵, 河内 泉, 佐治 越爾, 柳川 香織, 横関 明子, 豊島 靖子, 西澤 正豊

    臨床神経学   52 ( 12 )   1472 - 1472   2012.12

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  • Characteristic features of inflammatory demyelination and neurodegeneration in neuromyelitis optica spectrum disorder

    Musashi Arakawa, Yasuko Toyoshima, Etsuji Saji, Kaori Yanagawa, Akiko Yokoseki, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    JOURNAL OF NEUROIMMUNOLOGY   253 ( 1-2 )   148 - 148   2012.12

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  • 抗アクアポリン4抗体陽性視神経炎の維持療法と再発の検討

    山上 明子, 若倉 雅登, 田中 惠子, 高橋 利幸, 河内 泉

    神経眼科   29 ( 増補1 )   68 - 68   2012.10

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  • Diagnostic dilemma of Japanese patients with AQP4 antibody

    I. Kawachi, K. Yanagawa, E. Saji, M. Arakawa, A. Yokoseki, M. Hokari, M. Nishizawa

    MULTIPLE SCLEROSIS JOURNAL   18   71 - 72   2012.10

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  • 易疲労性、筋痛で発症し、T3271C点変異を有するミトコンドリア病19歳女性例の治療経験

    黒羽 泰子, 松原 奈絵, 長谷川 有香, 谷 卓, 他田 真理, 河内 泉, 西澤 正豊, 小池 亮子

    神経治療学   29 ( 5 )   653 - 653   2012.9

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  • 中年期以降に発症したADEMの臨床免疫学的特徴

    穂苅 万李子, 河内 泉, 柳川 香織, 佐治 越爾, 荒川 武蔵, 横関 明子, 西澤 正豊

    日本神経免疫学会学術集会抄録集   24回   122 - 122   2012.9

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  • 本邦neuromyelitis opticaにおける診断プロセスの解析

    柳川 香織, 河内 泉, 佐治 越爾, 荒川 武蔵, 横関 明子, 穂刈 万季子, 西澤 正豊

    日本神経免疫学会学術集会抄録集   24回   107 - 107   2012.9

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  • NMO Neuromyelitis opticaにおける神経変性機構の検討

    荒川 武蔵, 河内 泉, 豊島 靖子, 佐治 越爾, 柳川 香織, 横関 明子, 柿田 明美, 高橋 均, 西澤 正豊

    日本神経免疫学会学術集会抄録集   24回   58 - 58   2012.9

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  • 統合失調症様類似の精神症状を伴ったneuromyelitis opticaの解析

    横関 明子, 河内 泉, 柳川 香織, 佐治 越爾, 荒川 武蔵, 穂苅 万季子, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊

    日本神経免疫学会学術集会抄録集   24回   103 - 103   2012.9

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  • NMO/筋炎 Neuromyelitis opticaの末梢血CD4陽性T細胞における免疫動態解析

    佐治 越爾, 河内 泉, 荒川 武蔵, 柳川 香織, 横関 明子, 穂苅 万李子, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊

    日本神経免疫学会学術集会抄録集   24回   74 - 74   2012.9

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  • 多発性硬化症の新しい治療薬フィンゴリモドについて エキスパートによる処方経験を中心に

    糸山 泰人, 越智 博文, 齋田 孝彦, 河内 泉, 新野 正明

    Pharma Medica   30 ( 7 )   116 - 124   2012.7

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  • 免疫性神経疾患に関する調査研究 多発性硬化症/視神経脊髄炎(3)Neuromyelitis opticaにおける神経変性機構の解析

    西澤正豊, 佐治越爾, 河内泉, 荒川武蔵, 柳川香織, 横関明子, 豊島靖子, 柿田明美, 高橋均

    免疫性神経疾患に関する調査研究 平成23年度 総括・分担研究報告書   34 - 35   2012

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  • 免疫性神経疾患に関する調査研究 多発性硬化症/視神経脊髄炎(2)中枢神経系炎症性脱髄疾患におけるCCR6発現T細胞の解析

    西澤正豊, 河内泉, 佐治越爾, 柳川香織, 荒川武蔵, 横関明子, 豊島靖子, 柿田明美, 高橋均

    免疫性神経疾患に関する調査研究 平成23年度 総括・分担研究報告書   19 - 20   2012

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  • HDLSの分子病態と白質を主病変とする他疾患との異同

    池内健, 今野卓哉, 他田正義, 荒川武蔵, 岡崎健一, 小山哲秀, 酒井直子, 野崎洋明, 徳永純, 河内泉, 柿田明美, 高橋均, 西澤正豊, 小野寺理

    日本神経学会学術大会プログラム・抄録集   53rd   2012

  • 髄膜形態からみたneuromyelitis opticaの病態形成メカニズムの解析

    柳川 香織, 河内 泉, 豊島 靖子, 横関 明子, 佐治 越爾, 柿田 明美, 高橋 均, 西澤 正豊

    臨床神経学   51 ( 12 )   1235 - 1235   2011.12

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  • スペクトラルドメイン光干渉断層計を使った中枢神経系脱髄疾患の病態メカニズムの解析

    佐治 越爾, 河内 泉, 柳川 香織, 横関 明子, 高木 峰夫, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊

    臨床神経学   51 ( 12 )   1221 - 1221   2011.12

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  • 中枢神経系脱髄疾患におけるインターロイキン21動態の解析

    河内 泉, 佐治 越爾, 柳川 香織, 横関 明子, 西澤 正豊

    臨床神経学   51 ( 12 )   1395 - 1395   2011.12

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  • Absence of meningeal lymphoid neogenesis in neuromyelitis optica

    I. Kawachi, K. Yanagawa, Y. Toyoshima, E. Saji, M. Arakawa, A. Yokoseki, A. Kakita, H. Takahashi, M. Nishizawa

    MULTIPLE SCLEROSIS JOURNAL   17   S292 - S292   2011.10

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  • 周期性発熱に無菌性髄膜炎と認知機能障害を併発しinfliximabが有効であったautoinflammatory syndromeの1例

    二宮 格, 佐治 越爾, 河内 泉, 西澤 正豊

    神経治療学   28 ( 5 )   558 - 558   2011.9

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  • 脳炎 AMPA受容体抗体脳炎の髄液サイトカイン・ケモカイン解析

    荒川 武蔵, 河内 泉, 佐治 越爾, 柳川 香織, 横関 明子, 関根 有美, 堅田 慎一, 西澤 正豊

    日本神経免疫学会学術集会抄録集   23回   85 - 85   2011.9

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  • 自然免疫システムからみたneuromyelitis optica脊髄病変の解析

    柳川 香織, 河内 泉, 豊島 靖子, 荒川 武蔵, 横関 明子, 佐治 越爾, 柿田 明美, 高橋 均, 西澤 正豊

    日本神経免疫学会学術集会抄録集   23回   112 - 112   2011.9

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  • NMO-2 Neuromyelitis opticaにおけるインターロイキン21動態の解析

    佐治 越爾, 河内 泉, 柳川 香織, 横関 明子, 荒川 武蔵, 西澤 正豊

    日本神経免疫学会学術集会抄録集   23回   90 - 90   2011.9

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  • Inflammatory Myopathy Associated with Primary Biliary Cirrhosis

    Mariko Hokari, Izumi Kawachi, Etsuji Saji, Kaori Yanagawa, Akio Yokoseki, Yasuko Toyoshima, Masatoyo Nishizawa

    NEUROLOGY   76 ( 9 )   A105 - A105   2011.3

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  • 免疫性神経疾患に関する調査研究 MS/NMO 画像・高次脳機能 高次脳機能評価とスペクトラルドメイン光干渉断層計を使ったNMO病態の解析

    西澤正豊, 佐治越爾, 河内泉, 柳川香織, 横関明子, 豊島靖子, 高木峰夫, 柿田明美, 高橋均

    免疫性神経疾患に関する調査研究 平成22年度 総括・分担研究報告書   33 - 34   2011

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  • 免疫性神経疾患に関する調査研究 MS/NMO 画像・高次脳機能 多発性硬化症におけるBrief Repeatable Battery of Neuopsychological Tests in MultipleSclerosis(BRB‐N)を用いた高次脳機能評価と疲労及びアパシー(やる気)の影響に関しての研究

    菊地誠志, 新野正明, 三船恒裕, 大槻美佳, 宮本勝一, 河内泉, 深澤俊行

    免疫性神経疾患に関する調査研究 平成22年度 総括・分担研究報告書   35 - 36   2011

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  • 免疫性神経疾患に関する調査研究 MS/NMO 病理 髄膜形態からみたneuromyelitis opticaの病態形成メカニズム解析

    西澤正豊, 河内泉, 柳川香織, 佐治越爾, 横関明子, 豊島靖子, 柿田明美, 高橋均

    免疫性神経疾患に関する調査研究 平成22年度 総括・分担研究報告書   22 - 23   2011

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  • Neuromyelitis optica spectrum disorderの精神神経症状と高次脳機能障害

    佐治 越爾, 河内 泉, 柳川 香織, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊

    臨床神経学   50 ( 12 )   1211 - 1211   2010.12

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  • Potential role of cellular immunity in neuromyleitis optica

    Kawachi Izumi, Toyoshima Yasuko, Yanagawa Kaori, Saji Etsuji, Kakita Akiyoshi, Takahashi Hitoshi, Nishizawa Masatoyo

    JOURNAL OF NEUROIMMUNOLOGY   228 ( 1-2 )   138 - +   2010.11

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  • 亜急性進行性に経過する脳幹脳炎に末梢神経障害を伴った55歳男性例

    鳥谷部 真史, 徳永 純, 野崎 洋明, 吉野 秀昭, 佐治 越爾, 河内 泉, 下畑 享良, 西澤 正豊

    新潟医学会雑誌   124 ( 6 )   352 - 352   2010.6

  • MS/NMO リンパ球浸潤形態からみたneuromyelitis opticaの脊髄病変

    河内 泉, 柳川 香織, 豊島 靖子, 佐治 越爾, 柿田 明美, 高橋 均, 西澤 正豊

    日本神経免疫学会学術集会抄録集   22回   39 - 39   2010.3

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  • 脳炎など 抗NMDA受容体脳炎の髄液サイトカイン、ケモカインプロファイル解析

    佐治 越爾, 河内 泉, 西澤 正豊

    日本神経免疫学会学術集会抄録集   22回   62 - 62   2010.3

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  • 血清IgG4高値と自己免疫性膵炎を併発した封入体筋炎の1例

    穂苅 万李子, 春日 健作, 矢島 隆二, 佐治 越爾, 河内 泉, 西澤 正豊

    日本神経免疫学会学術集会抄録集   22回   70 - 70   2010.3

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  • Neuropsychiatric Presentation of Neuromyelitis Optica Spectrum Disorders

    Etsuji Saji, Yasuko Toyoshima, Kaori Yanagawa, Masatoyo Nishizawa, Izumi Kawachi

    NEUROLOGY   74 ( 9 )   A169 - A169   2010.3

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  • 免疫性神経疾患に関する調査研究 視神経脊髄炎・臨床 リンパ球浸潤形態からみたneuromyelitis opticaの脊髄病変

    西澤正豊, 河内泉, 柳川香織, 佐治越爾, 豊島靖子, 柿田明美, 高橋均

    免疫性神経疾患に関する調査研究班 平成21年度 総括・分担研究報告書   17 - 18   2010

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  • 免疫性神経疾患に関する調査研究 視神経脊髄炎・臨床 Neuromyelitis optica spectrum disorderの高次脳機能障害

    西澤正豊, 佐治越爾, 河内泉, 柳川香織, 豊島靖子, 柿田明美, 高橋均

    免疫性神経疾患に関する調査研究班 平成21年度 総括・分担研究報告書   19 - 20   2010

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  • 卵巣奇形腫に伴う傍腫瘍神経症候群の臨床的検討

    佐治 越爾, 河内 泉, 西澤 正豊

    臨床神経学   49 ( 12 )   1045 - 1045   2009.12

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  • 水痘・帯状疱疹ウイルス感染症の関与が疑われるVernet症候群の一例

    伊藤 岳, 野崎 洋明, 佐治 越爾, 河内 泉, 下畑 享良, 西澤 正豊

    NEUROINFECTION   14 ( 2 )   181 - 181   2009.10

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  • Neuromyelitis Optica and Idiopathic Thrombocytopenic Purpura

    Miho Akaza, Keiko Tanaka, Masami Tanaka, Izumi Kawachi, Teruhiko Sekiguchi, Kazutaka Nishina, Tamako Misawa, Hidehiro Mizusawa, Masatoyo Nishizawa, Takanori Yokota

    NEUROLOGY   72 ( 11 )   A190 - A190   2009.3

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  • The Anti-AQP4 Antibody Can Cause Damage of Blood-Brain-Barrier?

    Miho Akaza, Keiko Tanaka, Masami Tanaka, Izumi Kawachi, Teruhiko Sekiguchi, Kazutaka Nishina, Tamako Misawa, Hidehiro Mizusawa, Masatoyo Nishizawa, Takanori Yokota

    NEUROLOGY   72 ( 11 )   A190 - A190   2009.3

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  • 免疫性神経疾患に関する調査研究 視神経脊髄炎(NMO)の病態 視神経炎病変を伴わないlimited form of neuromyelitis opticaの臨床病理学的特徴

    西澤正豊, 柳川香織, 河内泉, 横関明子, 豊島靖子, 柿田明美, 高橋均

    免疫性神経疾患に関する調査研究班 平成20年度 総括・分担研究報告書   38 - 39   2009

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  • 免疫性神経疾患に関する調査研究 多発性硬化症・免疫病態 多発性硬化症におけるRORγt発現細胞の検討

    西澤正豊, 河内泉, 柳川香織

    免疫性神経疾患に関する調査研究班 平成20年度 総括・分担研究報告書   61 - 62   2009

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  • Phenotypic Features of T Cells Expressing ROR gamma t in Multiple Sclerosis

    Izumi Kawachi, Masatoyo Nishizawa

    CLINICAL IMMUNOLOGY   131   S26 - S26   2009

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    DOI: 10.1016/j.clim.2009.03.073

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  • The distinct lineage: Double negative T cells expressing IL-17 in multiple sclerosis

    Izumi Kawachi, Musashi Arakawa, Kaori Yanagawi, Masatoyo Nishizawa

    JOURNAL OF NEUROIMMUNOLOGY   203 ( 2 )   163 - 163   2008.10

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  • 抗ガングリオシド抗体陽性末梢神経障害を合併した急性散在性脳脊髄炎の2例

    横関 明子, 河内 泉, 柳川 香織, 川村 邦雄, 横関 明男, 金澤 雅人, 西澤 正豊

    NEUROINFECTION   13 ( 2 )   84 - 84   2008.9

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  • Identification of double negative T cells expressing IL-17 in multiple sclerosis

    Izumi Kawachi, Musashi Arakawa, Kaori Yanagawa, Masatoyo Nishizawa

    MULTIPLE SCLEROSIS   14   S130 - S130   2008.9

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  • 11 視神経周囲炎を呈したサルコイドーシスの1例(一般演題,第48回下越内科集談会)

    徳永 純, 下畑 享良, 高堂 裕平, 河内 泉, 田中 恵子, 西澤 正豊

    新潟医学会雑誌   122 ( 7 )   408 - 409   2008.7

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  • 5 10年間下位運動ニューロン症状のみを呈したALSの1剖検例(I.一般演題,第33回上信越神経病理懇談会)

    西平 靖, 譚 春鳳, 河内 泉, 高橋 均

    新潟医学会雑誌   122 ( 7 )   412 - 412   2008.7

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  • 視神経脊髄症状のみを反復するSLE2女性例の検討

    野村 俊春, 河内 泉, 石川 正典, 田中 惠子, 西澤 正豊

    臨床神経学   48 ( 6 )   439 - 439   2008.6

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  • Opsoclonus-ataxia syndrome(OAS)で発症した卵巣奇形腫関連傍腫瘍神経症候群の24歳女性例

    佐治 越爾, 河内 泉, 田中 惠子, 西澤 正豊

    神経治療学   25 ( 3 )   286 - 286   2008.5

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  • Clinically isolated syndromeと重症筋無力症を併発した胸腺腫の一例

    今野 卓哉, 河内 泉, 荒川 武蔵, 西澤 正豊

    神経免疫学   16 ( 1 )   135 - 135   2008.4

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  • 脳炎、筋炎、その他 HIV-negative inflammatory PMLの検討

    荒川 武蔵, 河内 泉, 今野 卓哉, 小澤 鉄太郎, 西澤 正豊

    神経免疫学   16 ( 1 )   111 - 111   2008.4

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  • 免疫性神経疾患に関する調査研究 多発性硬化症におけるCD4<sup>-</sup>CD8<sup>-</sup>DN T細胞の特徴〈第2報〉

    田中惠子, 河内泉, 柳川香織, 荒川武蔵, 西澤正豊

    免疫性神経疾患に関する調査研究 平成19年度 総括・分担研究報告書   38 - 39   2008

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  • 多発性硬化症におけるCD4-CD8- double-negative T細胞の特徴

    河内 泉, 田中 惠子, 西澤 正豊

    臨床神経学   47 ( 12 )   1098 - 1098   2007.12

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  • ADEM 病初期にMRI異常を呈さない重症急性散在性脳脊髄炎の検討

    徳永 純, 河内 泉, 柳川 香織, 野村 俊春, 石川 正典, 石原 智彦, 田中 惠子, 西澤 正豊

    NEUROINFECTION   12 ( 2 )   195 - 195   2007.9

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  • 皮膚病変を伴わず高度の四肢の感覚障害・筋力低下、両側顔面神経麻痺を呈した神経ボレリア症の66歳女性例

    高堂 裕平, 下畑 享良, 河内 泉, 田中 惠子, 西澤 正豊

    臨床神経学   47 ( 8 )   537 - 537   2007.8

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  • 多発単神経炎にて発症した胸腺腫合併全身性ループスエリテマトーデスの1例

    有泉 優子, 河内 泉, 田中 惠子, 西澤 正豊

    神経治療学   24 ( 3 )   382 - 382   2007.5

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  • 急性脳炎のグルタミン酸受容体自己免疫病態の解明から新たな治療法確立に向けた研究 傍腫瘍性神経症候群の宿主要因としての免疫動態の解析

    田中惠子, 谷卓, 河内泉, 西澤正豊, 出塚次郎

    急性脳炎のグルタミン酸受容体自己免疫病態の解明から新たな治療法確立に向けた研究 平成18年度 総括・分担研究報告書(1/2冊)   73 - 74   2007

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  • 免疫性神経疾患に関する調査研究 MSの細胞性免疫 多発性硬化症におけるCD4<sup>-</sup>CD8<sup>-</sup>double‐negative T細胞の特徴

    田中惠子, 河内泉, 西澤正豊

    免疫性神経疾患に関する調査研究 平成18年度 総括・分担研究報告書   37 - 38   2007

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  • 第8番染色体長腕に連鎖する成人発症良性遺伝性舞踏病

    原 賢寿, 下畑 享良, 三瓶 一弘, 河内 泉, 金澤 雅人, 春日 健作, 宮下 哲典, 桑野 良三, 辻 省次, 小野寺 理, 西澤 正豊, 本間 義章

    臨床神経学   46 ( 12 )   1119 - 1119   2006.12

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  • 免疫バランス制御におけるMAIT細胞(Mucosal‐Associated Invariant T cells)の重要性

    河内泉

    三共生命科学研究振興財団研究報告集   21   217 - 231   2005.10

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  • 舞踏運動を呈した症例に対する分子遺伝学的解析

    下畑 享良, 小野寺 理, 本間 義章, 廣田 紘一, 布村 仁一, 木村 哲也, 河内 泉, 三瓶 一弘, 西澤 正豊, 辻 省次

    臨床神経学   44 ( 3 )   149 - 153   2004.3

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    舞踏病あるいはハンチントン病(HD)疑い79例(男34例,女45例,平均48.8歳)に対し遺伝子診断を行った.家族歴ありは37家系39例(A群),なしは40例(B群)であった.A群の遺伝子解析では,HDが28家系29例,歯状核赤核淡蒼球ルイ体萎縮症(DRPLA)が5家系5例であった.ハンチントン病類縁疾患1型(HDL1),2型(HDL2),遺伝性脊髄小脳変性症17型(SCA17)はなかった.残り4家系は常染色体優性遺伝形式と考えられた2家系3例と,両親が血族結婚の2家系2例であった.B群ではHDが8例,DRPLAが2例で,HDL1,2,SCA17は認めず,診断不明が20例であった.HDの37例では,原因遺伝子の伸長アリルのCAGリピート数と発症年齢との間に負の相関を認めた.家族歴の有無により発症年齢,CAGリピート数に有意差はなかった.CAGリピート数49以上の7例の臨床症状は,腱反射亢進4例,小脳性運動失調3例,眼球運動障害2例,ジストニア1例と多彩であった.DRPLAの7例のCAGリピート数は平均65.8で,小脳性運動失調を2例に認めた

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  • 本邦における舞踏病症例の遺伝子解析

    下畑 享良, 小野寺 理, 本間 義章, 木村 哲也, 河内 泉, 三瓶 一弘, 辻 省次

    臨床神経学   43 ( 12 )   1016 - 1016   2003.12

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  • 炎症性筋疾患における樹状細胞の関与

    河内 泉, 田中 恵子, 辻 省次

    臨床神経学   42 ( 12 )   1389 - 1389   2002.12

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  • <学会記事>6 脊髄ヘルニアの一例(I. 一般演題)(第 43 回新潟画像医学研究会)

    佐藤 晶, 渡辺 雅人, 野崎 洋明, 河内 泉, 辻 省次

    新潟医学会雑誌   116 ( 6 )   287 - 287   2002.6

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  • 脊髄ヘルニアの一例

    佐藤 晶, 渡辺 雅人, 野崎 洋明, 河内 泉, 辻 省次

    新潟医学会雑誌   116 ( 6 )   287 - 287   2002.6

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  • ELISPOT法を使ったヒト多発筋炎特異的T細胞エピトープの同定

    河内泉, 田中恵子, 田中正美, 辻省次

    Neuroimmunology   10 ( 1 )   136 - 137   2002.2

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  • The involvement of dendritic cell in the inflammatory muscular disease ( Ministry of Health, Labour and Welfare S ).

    河内泉, 田中恵子, 辻省次

    免疫性神経疾患に関する調査研究 平成13年度総括・分担研究報告書   188 - 191   2002

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  • Cytotoxic T cell activity enhancement method using the CD40 ligand introduction adenovirus in the paraneoplastic neurological syndrome ( Ministry of Health, Labour and Welfare S ).

    田中恵子, 丁欣, 河内泉, 辻省次, 田中正美, 菊地利明

    免疫性神経疾患に関する調査研究 平成13年度総括・分担研究報告書   90 - 92   2002

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  • サルコイドーシス非乾酪性肉芽腫における樹状細胞の関与

    河内 泉, 田中 恵子, 田中 正美, 辻 省次

    日本免疫学会総会・学術集会記録   31   75 - 75   2001.12

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  • ELISPOT法による傍腫瘍性神経症候群での抗原ペプチド反応性T細胞の解析

    田中 恵子, 河内 泉, 辻 省次, 田中 正美

    臨床神経学   41 ( 11 )   952 - 952   2001.11

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  • 特発性脊髄ヘルニアの治療経験

    河内 泉, 野崎 洋明, 佐藤 晶, 下畑 光輝, 高橋 哲也, 辻 省次

    神経治療学   18 ( 5〜6 )   518 - 518   2001.11

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  • 著明な腹水で発症したCrow-Fukase症候群の一例

    堅田 慎一, 小林 央, 高橋 哲也, 河内 泉, 田中 恵子, 辻 省次, 宇野 友康, 伊藤 由美, 風間 順一郎, 下条 文武

    新潟医学会雑誌   115 ( 11 )   594 - 594   2001.11

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  • ヒト筋炎標的臓器におけるVα24+NKT細胞の解析

    河内 泉, 田中 恵子, 田中 正美, 辻 省次

    臨床神経学   41 ( 11 )   908 - 908   2001.11

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  • 眼球運動失行と低アルブミン血症を伴う早発型失調症(EAOH)の疾患遺伝子の同定

    伊達 英俊, 小野寺 理, 五十嵐 修一, 河内 泉, 田中 一, 小池 亮子, 辻 省次, 湯浅 龍彦, 植川 和利, 福原 信義

    新潟医学会雑誌   115 ( 10 )   543 - 544   2001.10

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  • ELISPOT assay for the Hu antigen epitope-reactive T cells in paraneoplastic limbic encephalitis with anti-Hu antibody

    K.Tanaka, I. Kawachi, M. Tanaka, S. Tsuji

    J Neuroimmunol   118   145   2001

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  • The prospect of neuroimmunology in the 21st century. Mechanism of autoimmunity in polymyositis Invited

    河内 泉, 田中 惠子, 田中 正美, 辻 省次

    医学のあゆみ 別冊   200 - 204   2001

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  • 抗Yo抗体陽性傍腫瘍性小脳変性症モデルマウス作成に向けての細胞傷害性T細胞誘導法の検討

    田中 恵子, 河内 泉, 辻 省次, 田中 正美

    臨床神経学   40 ( 12 )   1495 - 1495   2000.12

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  • Pyruvate kinase M1/M2 peptideはHLAA*2402ヒト多発性筋炎の原因となる候補ペプチドである

    河内 泉, 田中 恵子, 辻 省次, 田中 正美

    臨床神経学   40 ( 12 )   1422 - 1422   2000.12

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  • ヒト筋炎標的臓器におけるVα24+NKT細胞の性状と分布についての検討

    河内 泉, 田中 恵子, 田中 正美, 辻 省次

    日本免疫学会総会・学術集会記録   30   308 - 308   2000.11

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  • Pyruvate kinase M1/M2 peptideはHLA A<sup>*</sup>2402ヒト多発筋炎の原因となる候補ペプチドである (厚生省S)

    河内泉, 田中恵子, 田中正美, 辻省次

    免疫性神経疾患に関する調査研究班 平成11年度研究報告書   116 - 118   2000

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  • 多発性筋炎のT細胞受容体解析

    河内 泉, 田中 恵子, 田中 正美, 辻 省次

    臨床神経学   39 ( 12 )   1344 - 1344   1999.12

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  • Yo蛋白由来ペプチド免疫マウスにおける細胞傷害性T細胞の誘導

    田中 恵子, 河内 泉, 辻 省次, 田中 正美

    臨床神経学   39 ( 12 )   1325 - 1325   1999.12

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  • Pyruvate kinase M1/M2 peptideはHLA A*2402ヒト多発性筋炎の原因となる候補ペプチドである

    河内 泉, 田中 恵子, 田中 正美, 辻 省次

    日本免疫学会総会・学術集会記録   29   32 - 32   1999.10

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  • 26)5-FUによる白質脳症を呈した進行直腸癌の1例(一般演題, 第247回新潟外科集談会)

    須田 和敬, 加藤 崇, 桑原 明史, 畠山 悟, 多々 孝, 山本 智, 谷 達夫, 石川 裕之, 島村 公年, 岡本 春彦, 須田 武保, 酒井 靖夫, 畠山 勝義, 大竹 弘哲, 河内 泉, 平松 建, 保住 功, 相馬 芳明, 辻 省次

    新潟医学会雑誌   113 ( 5 )   287 - 288   1999.5

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  • 臨床的にChorea-Acanthocytosisが疑われ生食希釈負荷により赤血球形態異常を確認し得た1例

    姉崎 利治, 原田 隆, 河内 泉, 辻 省次, 小池 正

    臨床神経学   39 ( 2〜3 )   376 - 376   1999.2

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  • 頸部前屈により,頸部静脈灌流異常と頸部から胸部の硬膜外腔の拡大を認めた平山病の1例

    長谷川 有香, 西川 尚, 河内 泉, 佐藤 正久, 辻 省次

    臨床神経学   38 ( 9 )   865 - 865   1998.9

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  • 副腎皮質ステロイド・ワーファリン併用療法が著効を示した,post-irradiation lumbo-sacral radiculopathyの1例

    原田 隆, 河内 泉, 三瓶 一弘, 姉崎 利治, 辻 省次

    臨床神経学   38 ( 6 )   537 - 537   1998.6

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Presentations

  • 視神経脊髄炎スペクトラムの病態から見たB cell depletion therapiesのインパクト Invited

    河内泉

    第34回日本神経免疫学会学術研究集会  2022.10 

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  • 個別化医療に役立つ「免疫学的機序からみたrelapsing MSとprogressive MSの病態」最新情報 Invited

    河内泉

    第63回日本神経学会学術大会  2022.5 

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  • 多発性硬化症における痛みのメカニズム. 神経疾患における痛みを改めて考える−新たな概念「痛覚変調性疼痛 (nociplastic pain)」を含めて− Invited

    河内泉

    第63回日本神経学会学術大会  2022.5 

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  • 神経免疫性疾患の基礎と臨床〜視神経脊髄炎・多発性硬化症を中心に〜 Invited

    河内泉

    第5回日本免疫不全・自己炎症学会総会  2022.2 

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  • 第5回全国調査からみた多発性硬化症の重症度に寄与する因子の検討

    磯部紀子, 渡邉 充, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 越智博文, 中辻裕司, 福元尚子, 林 史恵, 宮﨑雄生, 藤盛寿一, 久冨木原健二, 奥野龍禎, 中村優理, 迫田礼子, 米元耕輔, 平良 遼志, 野村恭一, 山村隆, 藤原一男, 田中正美, 錫村明生, 清水優子, 清水潤, 園生雅弘, 松尾秀徳, 渡邊修, 深澤俊行, 荻野美恵子, 郡山達男, 斎田孝彦, 野村芳子, 横山和正, 神田 隆, 田原将行, 横田隆徳, 大橋高志, 鈴木則宏, 楠進, 栗山長門, 和泉唯信, 小池春樹, 佐藤 泰憲, 三澤園子, 村井弘之, 本村政勝, 吉川弘明, 中西恵美, 中村好一, 中村幸志, 坂田清美, 嶋田莉奈子, 松井真, 桑原聡, 吉良潤一, 河内泉

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和3年度班会議  2022.1 

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  • 炎症性グリア病である多発性硬化症と視神経脊髄炎における自己免疫炎症と神経変性病態の解析

    河内泉, 中島章博, 柳村文寛, 佐治越爾, 柳川香織, 若杉尚宏, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和3年度班会議  2022.1 

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  • 視神経脊髄炎における脳幹・小脳病変の解析

    河内泉, 佐治越爾, 柳村文寛, 中島章博, 柳川香織, 若杉尚宏, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和3年度班会議  2022.1 

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  • 免疫介在性肥厚性硬膜炎の臨床的特徴〜2017年暫定ACR/EULAR分類基準による検討〜

    河内泉, 中島章博, 佐治越爾, 若杉尚宏, 柳村文寛, 柳川香織, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和3年度班会議  2022.1 

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  • 「肥厚性硬膜炎」と「自己免疫介在性脳炎・脳症」の診断基準・重症度分類策定および診療ガイドライン策定に向けた現状と今後の課題.

    河内泉, 松井真, 神田隆, 大石真莉子, 佐治越爾, 中島章博, 飯塚高浩, 木村暁夫, 下島恭弘, 山崎亮, 高橋幸利, 野村恭一, 川合謙介

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和3年度班会議  2022.1 

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  • History of B-cell therapy and treatment optimization in Japan Invited

    Izumi Kawachi

    The 13th Pan-Asia Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS) Virtual Congress 2021  2021.11 

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  • 多発性硬化症の今~脳神経診療の腕のみせどころ~ Invited

    河内泉

    第9回日本難病医療ネットワーク学会学術集会  2021.11 

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  • Neurodegeneration in gray matter of MS and NMOSD. Hot Topic 8: Neurodegeneration in demyelinating CNS disease Invited

    Izumi Kawachi

    The 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)  2021.10 

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  • 視神経脊髄炎の新たな治療戦略と就労両立支援 Invited

    河内泉

    第39回日本神経治療学会学術集会  2021.10 

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  • Autoimmune neurologic disorders ~ What we have learned from MS and NMO ~ Invited

    Izumi Kawachi

    AOCN-NPSICON 2021 (5th Annual National Conference of Neuropathology Society of India (NPSICON 2021) with Asia-Oceanian Society of Neuropathology (AOCN) Congress)  2021.9 

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  • Therapeutic Inhibition of the Complement System in Neurological Disorders ~What we have learned from NMOSD and MG~ Invited

    Izumi Kawachi

    PACTALS 2021 NAGOYA  2021.9 

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  • 神経病理から見た多発性硬化症の炎症と変性 Invited

    河内泉

    第62回日本神経病理学会  2021.5 

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  • 教育セミナー2. 中枢神経系自己免疫・炎症疾患 (多発性硬化症, 視神経脊髄炎, 肥厚性硬膜炎, 自己免疫性介在性脳炎・脳症, 神経サルコイドーシス, 神経ベーチェット病) Invited

    河内泉

    第62回日本神経病理学会, 第16回神経病理コアカリキュラム教育セミナー  2021.5 

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  • 多発性硬化症の炎症性グリア変性と神経変性~進行型の病態update. シンポジウム 多発性硬化症: 再発によらない進行への理解を深める Invited

    河内泉

    第62回日本神経学会学術大会  2021.5 

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  • 視神経脊髄炎の治療〜update 2021 Invited

    河内泉

    第62回日本神経学会学術大会  2021.5 

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  • 肥厚性硬膜炎と自己免疫性脳炎・脳症の診断基準・重症度分類策定と今後の課題

    河内泉, 松井真, 神田隆, 飯塚高浩, 木村暁夫, 佐治越爾, 大石真莉子, 中島章博, 下島恭弘, 山崎亮, 高橋幸利, 野村恭一, 川合謙介

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和2年度班会議  2021.1 

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  • 多発性硬化症と視神経脊髄炎における炎症性グリア変性と神経変性の免疫病理学的・放射線学的検討

    河内泉, 柳村文寛, 佐治越爾, 中島章博, 柳川香織, 若杉尚宏, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和2年度班会議  2021.1 

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  • 多発性硬化症をはじめとする免疫性神経疾患合併妊娠における母体疾患活動性評価と胎児リスク評価の検討

    河内泉, 柳川香織, 佐治越爾, 若杉尚宏, 中島章博, 小野寺理, 村島温子

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和2年度班会議  2021.1 

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  • 免疫介在性肥厚性硬膜炎の臨床的・免疫学的・病理学的解析〜発症部位からの考察

    河内泉, 中島章博, 柳川香織, 佐治越爾, 若杉尚宏, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和2年度班会議  2021.1 

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  • 病態メカニズムからみたMSとNMOSD Invited

    河内泉

    第38回日本神経治療学会  2020.11 

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  • Clinical characteristics of patients with late-onset NMOSD in a Japanese cohort.

    Akihiro Nakajima, Etsuji Saji, Ayaka Ono, Takahiro Wakasugi, Fumihiro Yanagimura, Kaori Yanagawa, Osamu Onodera, Izumi Kawachi

    The 28th Annual Meeting of the European Charcot Foudation (Digital Edition)  2020.11 

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  • 医学界におけるDIVERSITY & INCLUSION Invited

    河内泉

    第67回日本消化器病学会甲信越支部例会・第89回日本消化器内視鏡学会甲信越支部例会合同支部例会  2020.11 

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  • 視神経脊髄炎の病態と新たな治療戦略〜「静かな革命」の時を迎えて〜 Invited

    河内泉

    第8回日本難病医療ネットワーク学会・第25回日本難病看護学会合同学術集会  2020.11 

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  • MSの認知機能障害とその評価 Invited

    河内泉

    第38回日本神経治療学会  2020.11 

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  • 診断ジレンマ:脳腫瘍と炎症性脱髄疾患 Invited

    河内泉

    第61回日本神経病理学会  2020.10 

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  • NMOSD治療におけるソリリスの可能性 Invited

    河内泉

    第61回日本神経学会総会  2020.8 

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  • 多発性硬化症と視神経脊髄炎のVBM解析からみたグリア変性病態の解析

    河内泉, 若杉尚宏, 佐治越爾, 柳村文寛, 穂苅万李子, 柳川香織, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和元年度班会議  2020.1 

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  • 第5回多発性硬化症・視神経脊髄炎全国臨床疫学調査成績報告 (第1報)

    吉良潤一, 磯部紀子, 中村優理, 松下拓也, 渡邉充, 迫田礼子, 福元尚子, 林史恵, 新野正明, 宮﨑雄生, 越智博文, 酒井康成, 中島一郎, 藤盛寿一, 中村好一, 中村幸志, 坂田清美, 河内泉, 中原仁, 久冨木原健二, 中辻裕司, 野村恭一, 山村隆, 藤原一男, 田中正美, 錫村明生, 清水優子, 桑原聡, 清水潤, 園生雅弘, 松尾秀徳, 渡邊修, 深澤俊行, 荻野美恵子, 郡山達男, 斎田孝彦, 野村芳子, 横山和正, 神田隆, 田原将行, 横田隆徳, 大橋高志, 鈴木則宏, 楠進, 栗山長門, 松井真

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和元年度班会議  2020.1 

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  • 多発性硬化症と視神経脊髄炎の臨床的特徴 - 過去28年間における変遷

    河内泉, 佐治越爾, 若杉尚宏, 柳村文寛, 穂苅万李子, 柳川香織, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和元年度班会議  2020.1 

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  • 免疫性神経疾患における妊娠・出産アウトカムの解析

    河内泉, 柳川香織, 佐治越爾, 若杉尚宏, 柳村文寛, 穂苅万李子, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和元年度班会議  2020.1 

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  • 肥厚性硬膜炎

    KAWACHI Izumi

    厚生労働科学研究費補助金(難治性疾患等政策研究事業(難治性疾患政策研究事業))「IgG4関連疾患の診断基準ならびに治療指針の確立を目指す研究」2019年度第2回岡崎班 内分泌神経領域分科会 2019年度第2回岡崎班 内分泌神経領域分科会  2019.12 

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  • ライマリーケア医が知っておくべき “治療可能な” 2次性頭痛「血管炎・肥厚性硬膜炎における頭痛診療のすべて」 Invited

    KAWACHI Izumi

    第47回日本頭痛学会  2019.11 

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  • 多発性硬化症治療の今〜脳神経内科医の腕の見せどころ Invited

    河内泉

    第37回日本神経治療学会  2019.11 

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  • 女性のライフスタイルに沿った治療〜QOL向上を目指して〜 Invited

    河内泉

    第37回日本神経治療学会  2019.11 

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  • Clinicoradiological features of the cerebellum in Japanese cohorts of MS and NMOSD

    Wakasugi T, Saji E, Yanagimura F, Hokari M, Yanagawa K, Onodera O, Kawachi I

    MULTIPLE SCLEROSIS JOURNAL (The 35th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS))  2019.9 

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  • Characterization of inflammatory axis of CNS lesions in neuromyelitis optica spectrum disorders

    Yanagimura F, Saji E, Wakasugi T, Hokari M, Toyoshima Y, Nakajima T, Takahashi H, Kakita A, Nishizawa M, Onodera O, Kawachi I

    MULTIPLE SCLEROSIS JOURNAL (The 35th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS))  2019.9 

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  • 神経免疫と神経変性 自己免疫疾患・多発性硬化症におけるグリアと神経変性の新知見 Invited

    河内 泉

    神経免疫学 (第31回神経免疫学会)  2019.9 

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  • Characteristic features of longitudinal cognitive function in a Japanese cohort of MS

    Kawachi I, Wakasugi T, Saji E, Yanagimura F, Hokari M, Yanagawa K, Onodera O

    MULTIPLE SCLEROSIS JOURNAL (8th Annual Meeting of the International MS Cognition Society (IMSCOGS))  2019.7 

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  • 神経学と免疫学のクロストークから読み解く神経疾患 − 多発性硬化症から認知症まで (教育講演) Invited

    Izumi Kawachi

    NEURO 2019, 第42回日本神経科学大会, 第62回日本神経化学会大会  2019.7 

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  • Insights into the disease concept and the boarder of NMOSD and MS: From the viewpoint of pathological study in MS Invited

    KAWACHI Izumi

    第60回日本神経学会総会  2019.5 

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  • MS患者の妊娠・出産・授乳 -診療の最前線- Invited

    KAWACHI Izumi

    第60回日本神経学会総会, 大阪  2019.5 

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  • Clinicopathological features of cognitive function in NMOSD and MS Invited International conference

    KAWACHI Izumi

    2019 International NMO Roundtable Conference. Guthy Jackson Charitable Foundation  2019.3 

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  • W20 Special Session 2 “Women as Patients and Caregivers: Improving Gender Equity and Labor Inclusion by Addressing Healthcare Disparities” Invited International conference

    KAWACHI Izumi

    W20 / 5th World Assembly for Women (WAW!)  2019.3 

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2018年度・視神経脊髄炎病巣における炎症極性の解析

    河内泉, 柳村文寛, 佐治越爾, 若杉尚宏, 穂苅万李子, 柳川香織, 小野寺理

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2018年度班会議  2019.1 

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2018年度・日本人多発性硬化症コホートにおける認知機能障害とその病態解析

    河内泉, 若杉尚宏, 佐治越爾, 柳村文寛, 穂苅万李子, 柳川香織, 小野寺理

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2018年度班会議  2019.1 

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  • Dynamics and potential roles of melanoma cell adhesion molecule in autoimmune disorders of the central nervous system

    Fumihiro Yanagimura, Etsuji Saji, Takahiro Wakasugi, Mariko Hokari, Izumi Kawachi

    第48回日本免疫学会  2018.12 

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  • 多発性硬化症・視神経脊髄炎の病態と治療のUP-TO-DATE Invited

    河内 泉

    臨床神経学 (平成30年度関東・甲信越地区生涯教育講演会)  2018.12 

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  • 多発性硬化症と視神経脊髄炎の病態と治療Update-4 視神経脊髄炎の病態と治療のUP-TO-DATE アクアポリン4抗体の発見で何が変わったのか? Invited

    河内 泉

    神経治療学 (第36回日本神経治療学会)  2018.11 

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  • 視神経脊髄炎の病態と治療のUP-TO-DATE;アクアポリン4抗体の発見で何が変わったのか? Invited

    河内泉

    神経治療学 (第36回日本神経治療学会)  2018.11 

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  • A longitudinal study of cognitive function in a Japanese cohort of NMO and MS International conference

    Takahiro Wakasugi, Etsuji Saji, Fumihiro Yanagimura, Mariko Hokari, Kaori Yanagawa, Osamu Onodera, Izumi Kawachi

    The 34th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)  2018.10 

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  • Unique clinical features of late-onset neuromyelitis optica spectrum disorders in a Japanese cohort. International conference

    Etsuji Saji, Akihiro Nakajima, Takahiro Wakasugi, Fumihiro Yanagimura, Kaori Yanagawa, Osamu Onodera, Izumi Kawachi

    The 34th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)  2018.10 

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  • Up-to-date pathology in NMO Invited International conference

    Kawachi Izumi

    BRAIN PATHOLOGY (第59回日本神経病理学会, 東京, 2018年. 19th International Congress of Neuropathology (ICN2018))  2018.9 

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  • Charcot’s conceptから見る視神経脊髄炎 Invited

    河内泉

    Neuroimmunology (第30回神経免疫学会)  2018.9 

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  • Cross-interaction of neuro-immune axis in multiple sclerosis Invited

    Izumi Kawachi

    第59回日本神経学会総会  2018.5 

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  • Double inversion recovery imaging MRI: A good tool to identify optic neuritis lesions in multiple sclerosis and neuromyelitis optica International conference

    Izumi Kawachi, Etsuji Saji, Mariko Hokari, Akiko Yokoseki, Takahiro Wakasugi, Fumihiro Yanagimura, Osamu Onodera

    The 70th. Annual meeting of the American Academy of Neurology  2018.4 

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2017年度・多発性硬化症第5回全国臨床疫学調査の課題と対策

    吉良潤一, 磯部紀子, 新野正明, 松下拓也, 酒井康成, 中村好一, 野村恭一, 山村隆, 藤原一男, 田中正美, 錫村明生, 中辻裕司, 清水優子, 河内泉, 桑原聡, 清水潤, 園生雅弘, 松尾秀徳, 渡邊修, 中島一郎, 深澤俊行, 荻野美恵子, 郡山達男, 斎田孝彦, 野村芳子, 横山和正, 神田隆, 田原将行, 横田隆徳, 大橋高志, 越智博文, 鈴木則宏, 楠進, 中村幸志, 栗山長門, 松井真

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2017年班会議  2018.1 

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2017年度・中枢神経系自己免疫疾患における視神経病変のMRIに関する研究

    河内泉, 柳村文寛, 佐治越爾, 若杉尚宏, 横関明子, 穂苅万李子, 荒川武蔵, 柳川香織, 小野寺理

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2017年度班会議  2018.1 

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2017年度・中枢神経系自己免疫疾患の臨床経過と認知機能に関する研究

    河内泉, 若杉尚宏, 佐治越爾, 柳村文寛, 穂苅万李子, 柳川香織, 小野寺理

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2017年度班会議  2018.1 

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  • エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2017年度・特発性肥厚性硬膜炎の診断基準・重症度分類に関する研究

    河内泉, 佐治越爾, 横関明子, 柳村文寛, 若杉尚宏, 穂苅万李子, 柳川香織, 小野寺理

    エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立 2017年度班会議  2018.1 

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  • Clinical, radiological and immunological features of ependymitis in neuromyelitis optica

    Kawachi I, Yanagimura F, Saji E, Wakasugi T, Hokari M, Toyoshima Y, Kakita A, Takahashi H, Nishizawa M, Onodera O

    JOURNAL OF THE NEUROLOGICAL SCIENCES (The XXIII World Congress of Neurology, Kyoto, Japan)  2017.10 

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  • Dynamics of melanoma cell adhesion molecule on the blood vessels in neuromyelitis optica

    Yanagimura F, Saji E, Wakasugi T, Hokari M, Toyoshima Y, Kakita A, Takahashi H, Nishizawa M, Onodera O, Kawachi I

    JOURNAL OF THE NEUROLOGICAL SCIENCES (The XXIII World Congress of Neurology, Kyoto, Japan)  2017.10 

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  • A follow-up study of cognitive assessments in a Japanese cohort of multiple sclerosis

    Saji E, Wakasugi T, Hokari M, Yanagimura F, Yanagawa K, Nishizawa M, Onodera O, Kawachi I

    JOURNAL OF THE NEUROLOGICAL SCIENCES (The XXIII World Congress of Neurology, Kyoto, Japan)  2017.10 

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  • Double inversion recovery MRI in the evaluation of the anterior visual pathway in patients with multiple sclerosis and neuromyelitis optica spectrum disorders International conference

    Etsuji Saji, Mariko Hokari, Akiko Yokoseki, Takahiro Wakasugi, Fumihiro Yanagimura, Kaori Yanagawa, Masatoyo Nishizawa, Osamu Onodera, Izumi Kawachi

    The 33nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)  2017.10 

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  • Dynamics of tissue regulatory T cells in Neuromyelitis optica spectrum disorders lesions International conference

    Fumihiro Yanagimura, Etsuji Saji, Takahiro Wakasugi, Mariko Hokari, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Osamu Onodera, Izumi Kawachi

    The 33nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). Paris, France  2017.10 

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  • Evaluation of the 2016 diagnostic approach for autoimmune encephalitis International conference

    Takahiro Wakasugi, Etsuji Saji, Fumihiro Yanagimura, Mariko Hokari, Masatoyo Nishizawa, Osamu Onodera, Izumi Kawachi

    JOURNAL OF THE NEUROLOGICAL SCIENCES (The XXIII World Congress of Neurology, Kyoto, Japan)  2017.9 

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  • Clinical, radiological and immunological features of orbital inflammatory pseudotumor with neurological involvement in a Japanese cohort International conference

    Izumi Kawachi, Mana Nishida, Etsuji Saji, Takahiro Wakasugi, Mariko Hokari, Fumihiro Yanagimura, Masatoyo Nishizawa, Osamu Onodera

    JOURNAL OF THE NEUROLOGICAL SCIENCES (The XXIII World Congress of Neurology, Kyoto, Japan)  2017.9 

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  • Current topics of myelin biology and beyond:Up-to-date knowledge on pathomechanism of MS and related disorders. (シンポジウム) Invited

    Izumi Kawachi, Masatoyo Nishizawa, Osamu Onodera

    第60回日本神経化学会大会  2017.9 

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  • Distinct patterns of clinical courses and neurodegenerative/immunological processes in NMOSD and MS Invited International conference

    Izumi Kawachi, Fumihiro Yanagimura, Naohiro Wakasugi, Etsuji Saji, Mariko Hokari, Akiko Yokoseki, Musashi Arakawa, Kaori Yanagawa, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Osamu Onodera, Masatoyo Nishizawa

    The 9th Annual Neuromyelitis optica roudtabel conference. Guthy Jackson Charitable Foundation  2017.3 

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  • Severe neurodegeneration and unique dynamics of aquaporin-4 on astrocytes in the anterior visual pathway of neuromyelitis optica. International conference

    Kawachi I, Hokari M, Yokoseki A, Arakawa M, Saji E, Yanagawa K, Yanagimura F, Toyoshima Y, Kakita A, Takahashi H, Onodera O, Nishizawa M

    MULTIPLE SCLEROSIS JOURNAL (The 32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS))  2016.9 

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  • Involvement of anterior visual pathway in multiple sclerosis and neuromyelitis opitca Invited

    KAWACHI Izumi

    The 3rd MS Summer College in Kobe  2016.8 

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  • 多発性硬化症の診断と治療「グラチラマー酢酸塩の位置付け」(ランチョンセミナー) Invited

    KAWACHI Izumi

    第57回日本神経学会総会  2016.5 

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  • Severe neurodegeneration and unique dynamics of astrocytes/Müller cells with alterations of aquaporin-4 in neuromyelitis optica. Invited International conference

    Izumi Kawachi, Mariko Hokari, Akiko Yokoseki, Musashi Arakawa, Etsuji Saji, Kaori Yanagawa, Fumihiro Yanagimura, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa

    The 8th Annual Neuromyelitis optica roudtabel conference. Guthy Jackson Charitable Foundation  2016.3 

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  • 多発性硬化症の早期診断と早期治療のUP-TO-DATE Invited

    KAWACHI Izumi

    第33回日本神経治療学会  2015.11 

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  • シンポジウム4「認知症と神経免疫」多発性硬化症と視神経脊髄炎における認知機能障害と神経変性 Invited

    河内泉, 西澤正豊

    Neuroimmunology (第27回神経免疫学会)  2015.9 

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  • 神経病理学におけるベストエビデンス;中枢神経系自己免疫疾患におけるベストエビデンス Invited

    河内泉, 西澤正豊

    第56回日本神経病理学会  2015.6 

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  • 多発性硬化症に対する疾患修飾薬の使い分け. (イブニングセミナー) Invited

    KAWACHI Izumi

    第56回日本神経学会総会  2015.5 

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  • Immunopathology of NMO Invited

    Izumi Kawachi, Masatoyo Nishizawa

    第56回日本神経学会総会  2015.5 

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  • Role of meningeal lymphoid follicle-like structures in the CNS inflammatory disorders International conference

    Izumi Kawachi, Mariko Hokari, Etsuji Saji, Yasuko Toyoshima, Akiko Yokoseki, Kaori Yanagawa, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa

    The 12th International Congress of Neuroimmunology  2014.11 

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  • 多発性硬化症治療の新しいターゲット~今できること,今後の可能性について~(イブニングセミナー) Invited

    河内泉

    Neuroimmunogy (第26回神経免疫学会  2014.9 

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  • 細胞性免疫機構からみたNMO Invited

    河内泉, 西澤正豊

    Neuroimmunology (第26回神経免疫学会)  2014.9 

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  • Clinical and radiological profiles of anterior visual pathway involvement in neuromyelitis optica

    Kawachi I, Yokoseki A, Saji E, Hokari M, Yanagawa K, Nishizawa M

    MULTIPLE SCLEROSIS JOURNAL (2014 Joint ACTRIMS-ECTRIMS Meeting)  2014.9 

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  • ワークショップ: MS、NMO そして PML の神経病理学の新たな展開. 視神経脊髄炎と多発性硬化症の大脳皮質病変とその臨床的意義 Invited

    河内泉, 西澤正豊

    第55回日本神経病理学会,  2014.6 

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  • Optic Perineuritis-like Lesions in Neuromyelitis Optica: Radiological Assessments

    Yokoseki Akiko, Saji Etsuji, Arakawa Musashi, Hokari Mariko, Nishizawa Masatoyo, Kawachi Izumi

    MULTIPLE SCLEROSIS JOURNAL (The 6th Congress of the Pan-Asia Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS))  2014.6 

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  • Paraneoplastic Anti-NMDA Receptor Encephalitis Presenting With Neuromyelitis Optica-Like Relapses

    Yanagimura Fumihiro, Kawachi Izumi, Saji Estuji, Hokari Mariko, Yokoseki Akiko, Arakawa Musashi, Nishizawa Masatoyo

    MULTIPLE SCLEROSIS JOURNAL (The 6th Congress of the Pan-Asia Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS))  2014.6 

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  • Neuromyelitis Optica with Severe Progressive Cognitive and Psychiatric Impairment: Pathological Analysis of Three Autopsied Cases

    Arakawa Musashi, Saji Etsuji, Toyoshima Yasuko, Hokari Mariko, Yokoseki Akiko, Kakita Akiyoshi, Takahashi Hitoshi, Nishizawa Masatoyo, Kawachi Izumi

    MULTIPLE SCLEROSIS JOURNAL (The 6th Congress of the Pan-Asia Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS))  2014.6 

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  • Differential dynamics of immune cells in CSF and blood of patients with multiple sclerosis under fingolimod therapy

    YOKOSEKI Akiko, SAJI Etsuji, ARAKAWA Musashi, HOKARI Mariko, NISHIZAWA Masatoyo, KAWACHI Izumi

    第43回日本免疫学会  2013.12 

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  • Radiological and Pathological Analyses of Cortical Lesions in Inflammatory Demyelinating Diseases of the Central Nervous System International conference

    Etusji SAJI, Musashi ARAKAWA, Akiko YOKOSEKI, Mariko HOKARI, Yasuko TOYOSHIMA, Akiyoshi KAKITA, Hitoshi TAKAHASHI, Masatoyo NISHIZAWA, Izumi KAWACHI

    The 6th Congress of the Pan-Asia Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)  2013.10 

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  • Clinical Profiles of Elderly Patients with ADEM in A Japanese Cohort International conference

    Mariko Hokari, Etsuji Saji, Akiko Yokoseki, Musashi Arakawa, Masatoyo Nishizawa, Izumi Kawachi

    The 6th Congress of the Pan-Asia Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)  2013.10 

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  • Longitudinal flow cytometric profiles of immune cells in the cerebrospinal fluid and blood of patients with multiple sclerosis under fingolimod therapy

    Kawachi I, Yokoseki A, Saji E, Arakawa M, Hokari M, Nishizawa M

    MULTIPLE SCLEROSIS JOURNAL (The 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS))  2013.10 

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  • CNS pathology in neuromyelitis optica: region-dependent dynamics of aquaporin-4

    Arakawa M, Saji E, Toyoshima Y, Hokari M, Yokoseki A, Kakita A, Takahashi H, Nishizawa M, Kawachi I

    MULTIPLE SCLEROSIS JOURNAL (The 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS))  2013.10 

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  • Characteristic features of inflammatory demyelination and neurodegeneration in neuromyelitis optica spectrum disorder

    Arakawa Musashi, Toyoshima Yasuko, Saji Etsuji, Yanagawa Kaori, Yokoseki Akiko, Kakita Akiyoshi, Takahashi Hitoshi, Nishizawa Masatoyo, Kawachi Izumi

    JOURNAL OF NEUROIMMUNOLOGY (The 11th International Congress of Neuroimmunology)  2012.12 

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  • Potential role of CCR6+T cells in inflammatory demyelinating diseases of central nervous system

    Saji Etsuji, Arakawa Musashi, Hokari Mariko, Toyosima Yasuko, Yanagawa Kaori, Yokoseki Akiko, Kakita Akiyoshi, Takahashi Hitsohi, Nishizawa Masatoyo, Kawachi Izumi

    JOURNAL OF NEUROIMMUNOLOGY (The 11th International Congress of Neuroimmunology)  2012.12 

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  • Diagnostic dilemma of Japanese patients with AQP4 antibody

    Kawachi I, Yanagawa K, Saji E, Arakawa M, Yokoseki A, Hokari M, Nishizawa M

    MULTIPLE SCLEROSIS JOURNAL (The 27th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)  2012.10 

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  • Characteristic features of cognitive dysfunction in neuromyelitis optica and multiple sclerosis International conference

    Saji E, Yanagawa K, Toyoshima Y, Arakawa M, Yokoseki A, Hokari M, Nishizawa M, Kawachi I

    The 5th Congress of the Pan-Asia Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)  2012.9 

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  • Possible role of subarachnoid space as the initiating site for triggering the immune-mediated injury in CNS demyelinating diseases International conference

    Kawachi I, Saji E, Yanagawa K, Toyoshima Y, Arakawa M, Yokoseki A, Hokari M, Kakita A, Takahashi H, Nishizawa M

    The 5th Congress of the Pan-Asia Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)  2012.9 

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  • Characteristic features of cognitive dysfunction in neuromyelitis optica

    Saji E, Yanagawa K, Toyoshima Y, Arakawa M, Yokoseki A, Nishizawa M, Kawachi I

    MULTIPLE SCLEROSIS JOURNAL (5th Joint Triennial Congress of the European and Americas Committee for Treatment and Research in Multiple Sclerosis)  2011.10 

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  • Absence of meningeal lymphoid neogenesis in neuromyelitis optica

    Kawachi I, Yanagawa K, Toyoshima Y, Saji E, Arakawa M, Yokoseki A, Kakita A, Takahashi H, Nishizawa M

    MULTIPLE SCLEROSIS JOURNAL (5th Joint Triennial Congress of the European and Americas Committee for Treatment and Research in Multiple Sclerosis)  2011.10 

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  • 新規T細胞系列と多発性硬化症・NMO Invited

    河内泉, 西澤正豊

    日本神経免疫学会学術集会抄録集 (第22回神経免疫学会)  2010.3 

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  • NMOSD・MSにおけるステージ依存性免疫細胞動態の解析

    中島章博, 柳村文寛, 佐治越爾, 清水宏, 豊島靖子, 柳川香織, 柿田明美, 小野寺理, 河内泉

    第65回日本神経病理学会総会学術研究会  2024.5 

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  • 第19回神経病理コアカリキュラム教育セミナー. 3. 中枢神経系自己免疫性・炎症性疾患と白質ジストロフィー Invited

    河内泉

    第65回日本神経病理学会総会学術研究会  2024.5 

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  • ANCA関連肥厚性硬膜炎の臨床と病理. ワークショップ5. 知っておきたい抗好中球細胞質抗体 (ANCA) 関連症候: 臨床と病理 Invited

    河内泉

    第113回日本病理学会総会  2024.3 

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  • (幹事発表)「自己免疫介在性脳炎・脳症」(NMDA受容体抗体脳炎・LGI1抗体脳炎) の診断基準・重症度分類および診療ガイドライン策定に向けた全国調査 (一次調査及び二次調査結果)

    河内泉, 佐藤泰憲, 飯塚高浩, 木村暁夫, 中嶋秀人, 佐久間啓, 佐治越爾, 大石真莉子, 中島章博, 渡邉修, 高橋幸利, 神田隆

    難治性疾患等政策研究事業(難治性疾患政策研究事業)「神経免疫疾患領域における難病の医療水準と患者のQOL向上に資する研究 (神経免疫班)」研究班 令和5年度班会議  2024.1 

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  • 挙児希望を叶えるための横断的指針に向けた「神経免疫疾患の横串解析」

    河内泉, 伊﨑祥子, 鵜沢顕之, 岡本智子, 野原千洋子, 横山和正, 赤松直樹, 伊藤泰広, 滝沢翼, 村島温子, 清水優子

    難治性疾患等政策研究事業(難治性疾患政策研究事業)「神経免疫疾患領域における難病の医療水準と患者のQOL向上に資する研究 (神経免疫班)」研究班 令和5年度班会議  2024.1 

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  • 自己免疫性グリア病である多発性硬化症と視神経脊髄炎におけるステージ依存性免疫細胞の解析

    河内泉, 中島章博, 柳村文寛, 佐治越爾, 柳川香織, 若杉尚宏, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業)「神経免疫疾患領域における難病の医療水準と患者のQOL向上に資する研究 (神経免疫班)」研究班 令和5年度班会議  2024.1 

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  • Dynamics of MCAM expression on endothelial cells in neuromyelitis optica spectrum disorders

    Nakajima A, Saji E, Yangimura F, Yanagawa K, Shimizu H, Toyoshima Y, Kakita A, Onodera O, Kawachi I

    MS Milan 2023, 9th Joint ECTRIMS-ACTRIMS Meeting  2023.10 

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  • Neuro-immune crosstalk: lessons learned from immunological features and neurodegenerative processes in MS and NMOSD Invited

    Izumi Kawachi

    第35回日本神経免疫学会学術研究集会  2023.9 

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  • 妊娠・出産が免疫性神経疾患の長期予後に与える影響の検討

    栁川香織, 佐治越爾, 中島章博, 小野寺理, 河内泉

    第35回日本神経免疫学会学術研究集会  2023.9 

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  • ACR/EULAR IgG4関連疾患分類基準(2019)における免疫介在性肥厚性硬膜炎の臨床病理学的検討

    中島章博, 佐治越爾, 清水宏, 豊島靖子, 岡本浩一郎, 柳川香織, 三瓶一弘, 柿田明美, 小野寺理, 河内泉

    第35回日本神経免疫学会学術研究集会  2023.9 

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  • 自己免疫介在性脳炎・脳症の全国疫学調査における抗NMDA受容体脳炎の一次調査報告

    佐治越爾, 佐藤泰憲, 飯塚高浩, 木村暁夫, 佐久間啓, 中嶋秀人, 大石真莉子, 中島章博, 神田隆, 高橋幸利, 河内泉

    第35回日本神経免疫学会学術研究集会  2023.9 

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  • 自己免疫介在性脳炎・脳症の全国疫学調査における抗LGI1脳炎の一次調査報告

    河内泉, 佐治越爾, 佐藤泰憲, 飯塚高浩, 木村暁夫, 佐久間啓, 中嶋秀人, 大石真莉子, 中島章博, 神田隆, 高橋幸利

    第35回日本神経免疫学会学術研究集会  2023.9 

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  • MS/NMOSD診療から考えるリアルワールドデータ (RWD)/エビデンス (RWE) の利活用 Invited

    河内泉

    第35回日本神経免疫学会学術研究集会  2023.9 

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  • 日本と世界のNMOSD update~病態と治療~ Invited

    河内泉

    第64回日本神経病理学会総会学術研究会・第66回日本神経化学会大会 合同大会  2023.7 

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  • Motor and non-motor symptoms of NMOSD〜病態と治療 update 2023〜 Invited

    河内泉

    第28回認知神経科学会学術集会  2023.7 

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  • 神経疾患. 母性内科学会との共同シンポジウム 内科疾患合併妊娠の現状と課題 Invited

    河内泉

    第59回日本周産期・新生児医学会学術集会  2023.7 

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  • 視神経脊髄炎の治療 Invited

    河内泉

    第60回日本神経眼科学会総会  2023.7 

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  • Respiratory failure caused by brainstem demyelinating lesions in an elderly patient with a suspected autoimmune disorder

    Shoko Hongo, Hiroshi Shimizu, Etsuji Saji, Akihiro Nakajima, Izumi Kawachi, Osamu Onodera, Akiyoshi Kakita

    第64回日本神経病理学会総会学術研究会・第66回日本神経化学会大会 合同大会  2023.7 

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  • 減圧開頭術を要した腫瘤形成性脱髄病変の臨床免疫病理学的検討

    中島章博, 佐治越爾, 清水宏, 豊島靖子, 岡本浩一郎, 柳川香織, 棗田学, 柿田明美, 小野寺理, 河内泉

    第64回日本神経病理学会総会学術研究会・第66回日本神経化学会大会 合同大会  2023.7 

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  • 自然免疫からみた脳内炎症とその治療 (シンポジウム) Invited

    河内泉

    第64回日本神経学会学術大会  2023.5 

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  • MS/NMOSDの治療とケア Invited

    河内泉

    新潟市薬剤師会学術講演会  2023.5 

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  • 視神経脊髄炎における妊娠・出産マネージメントの検討~妊娠前・中・後治療の観点から

    柳川香織, 佐治越爾, 中島章博, 小野寺理, 河内 泉

    第64回日本神経学会学術大会  2023.5 

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  • 緊急減圧術を要した肥厚性硬膜炎の臨床病理学的特徴の解析

    中島章博, 佐治越爾, 清水宏, 豊島靖子, 岡本浩一郎, 若杉尚宏, 柳村文寛, 三瓶一弘, 柿田明美, 小野寺理, 河内泉

    第64回日本神経学会学術大会  2023.5 

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  • 妊娠と授乳:ステロイド~生物学的製剤まで (教育コースシンポジウム) Invited

    河内泉

    第64回日本神経学会学術大会  2023.5 

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  • 「自己免疫介在性脳炎・脳症」(抗NMDA受容体脳炎・抗LGI1脳炎) の診断基準・重症度分類および診療ガイドライン策定に向けた全国調査

    河内泉, 神田隆, 飯塚高浩, 木村暁夫, 佐久間啓, 佐治越爾, 大石真莉子, 中島章博, 松井真, 高橋幸利

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和4年度班会議  2023.1 

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  • 長期経過の観察を基にしたIgG4関連肥厚性硬膜炎の臨床的特徴

    河内泉, 中島章博, 佐治越爾, 柳村文寛, 柳川香織, 若杉尚宏, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和4年度班会議  2023.1 

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  • 視神経脊髄炎と多発性硬化症における短い脊髄病変 (non-long spinal cord lesion) の検討

    河内泉, 佐治越爾, 柳村文寛, 中島章博, 柳川香織, 若杉尚宏, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和4年度班会議  2023.1 

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  • 自己免疫性グリア病である多発性硬化症と視神経脊髄炎における自然免疫機構の解析

    河内泉, 中島章博, 柳村文寛, 佐治越爾, 柳川香織, 若杉尚宏, 小野寺理

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和4年度班会議  2023.1 

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  • Whole person careの視点から考えるNMOSD治療戦略〜C5治療戦略を中心に〜視神経脊髄炎の新たな治療戦略と就労両立支援 Invited

    河内泉

    第40回日本神経治療学会学術集会  2022.11 

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  • 自己免疫性視神経炎の診療アップデート2022 Invited

    河内泉

    第40回日本神経治療学会学術集会  2022.11 

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  • 脊髄病変で再発した視神経脊髄炎関連疾患の臨床的特徴

    佐治越爾, 中島章博, 栁川香織, 小野寺理, 河内泉

    第34回日本神経免疫学会学術研究集会  2022.10 

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  • 多発性硬化症女性における妊娠・出産の安全性と児への影響の検討

    栁川香織, 佐治越爾, 中島彰博, 梅田麻衣子, 梅田能生, 藤田信也, 小野寺理, 河内泉

    第34回日本神経免疫学会学術研究集会  2022.10 

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  • 日本人多発性硬化症患者における健康関連quality of lifeの検討

    新野 正明, 福元 尚子, 奥野 龍禎, 三條 伸夫, 深浦 彦彰, 森 雅裕, 大橋 高志, 竹内 英之, 清水 優子, 藤盛 寿一, 河内 泉, 吉良 潤一, 高橋 恵里, 宮﨑 雄生, 三船 恒裕

    第34回日本神経免疫学会学術研究集会  2022.10 

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  • 長期経過を踏まえたIgG4関連肥厚性硬膜炎の臨床的特徴の解析

    中島章博, 佐治越爾, 清水宏, 豊島靖子, 岡本浩一郎, 若杉尚宏, 柳村文寛, 柳川香織, 三瓶一弘, 柿田明美, 小野寺理, 河内泉

    第34回日本神経免疫学会学術研究集会  2022.10 

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  • 第5回全国調査からみる多発性硬化症の二次性進行型に移行するリスク因子の検討

    渡邉充, 磯部紀子, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 河内泉, 越智博文, 中辻裕司, 中村好一, 中村幸志, 坂田清美, 松井真, 桑原聡, 吉良潤一

    第34回日本神経免疫学会学術研究集会  2022.10 

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  • Pros & Cons 2022年の多発性硬化症診療を考える. Pros「#2. 多発性硬化症は神経変性疾患である」 Invited

    佐治 越爾, 河内泉

    第34回日本神経免疫学会学術研究集会  2022.10 

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  • Long-term efficacy of satralizumab in adults with AQP4+ neuromyelitis optica spectrum disorder (NMOSD): Results from the phase 3 SAkura studies

    Izumi Kawachi, Jeffrey L. Benne, Edward Fox, Benjamin Greenberg, Brian G. Weinshenker, Anthony Traboulsee, Michael R. Yeaman, Kathleen Blondeau, Kristina Weber, Shervin Gholizadeh, Ivana Vodopivec, Michael Levy

    第34回日本神経免疫学会学術研究集会  2022.10 

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  • 社会情動的スキル (自尊感情) が多職種連携教育に及ぼす影響.

    河内泉, 中島寛音, 中嶋大和, 青木亜美, Razvina Olga, 福井直樹, 齋藤昭彦, 土田正則, 佐藤昇, 染矢俊幸

    第54回 日本医学教育学会大会  2022.8 

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  • COVID-19パンデミックにおける教育実践〜遠隔同期型の多職種連携教育における学修効果の解析

    河内泉, 中島寛音, 中嶋大和, 青木亜美, Razvina Olga, 福井直樹, 齋藤昭彦, 土田正則, 佐藤昇, 染矢俊幸

    第54回 日本医学教育学会大会  2022.8 

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  • 日本人多発性硬化症患者における認知機能とQOL,疲労,抑うつとの相関

    新野正明, 福元尚子, 奥野龍禎, 三條伸夫, 深浦彦彰, 森雅裕, 大橋高志, 竹内英之, 清水優子, 藤盛寿一, 河内泉, 吉良潤一, 高橋恵里, 宮﨑雄生, 三船恒裕

    第63回日本神経学会学術大会  2022.5 

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  • Hypertrophic pachymeningitis; analysis based on the 2017 provisional ACR/EULAR classification criteria for GPA

    Akihiro Nakajima, Etsuji Saji, Hiroshi Shimizu, Kouichirou Okamoto, Takahiro Wakasugi, Fumihiro Yanagimura, Kaori Yanagawa, Kazuhiro Sanpei, Hirotoshi Kikuchi, Shunsei Hirohata, Yasuko Toyoshima, Akiyoshi Kakita, Osamu Onodera, Izumi Kawachi

    第63回日本神経学会学術大会  2022.5 

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  • AQP4抗体陽性視神経脊髄炎関連疾患における脳幹小脳症状と病変分布

    佐治越爾, 中島章博, 栁川香織, 小野寺理, 河内泉

    第63回日本神経学会学術大会  2022.5 

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  • COVID-19 mRNAワクチン接種後に腫瘤形成性脱髄病変を呈した36歳女性例

    岩淵洋平, 佐治越爾, 本郷祥子, 清水宏, 岡本浩一郎, 柿田明美, 小野寺理, 河内泉

    第240回日本神経学会関東地方会  2022.3 

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  • 日本人多発性硬化症患者における認知機能とQOL,疲労,抑うつとの相関

    新野正明, 福元尚子, 奥野龍, 三條伸夫, 深浦彦彰, 森雅裕, 大橋高志, 竹内英之, 清水優子, 藤盛寿一, 吉良潤一, 高橋恵里, 宮﨑雄生, 三船恒裕, 河内泉

    難治性疾患等政策研究事業(難治性疾患政策研究事業) 「神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイド ラインの妥当性と患者QOLの検証」研究班 令和3年度班会議  2022.1 

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  • 小脳失調で発症し造血幹細胞移植を行った小脳脳幹型副腎白質ジストロフィーの39歳男性例

    渡邉緑, 佐治越爾, 小野純花, 柴崎康彦, 松川敬志, 辻省次, 小野寺理, 河内泉

    第239回日本神経学会関東・甲信越地方会  2021.12 

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  • Cognitive impairment in MS patients Factors affecting cognitive impairment in Japanese patients with multiple sclerosis.

    Masaaki Niino, Shoko Fukumoto, Tatsusada Okuno, Nobuo Sanjo, Hikoaki Fukaura, Masahiro Mori, Takashi Ohashi, Hideyuki Takeuchi, Yuko Shimizu, Juichi Fujimori, Jun-ichi Kira, Eri Takahashi, Yusei Miyazaki, Nobuhiro Mifune, Izumi Kawachi

    The 29th Annual Meeting of the European Charcot Foudation 2021 (Digital Edition)  2021.11 

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  • 視神経脊髄炎関連疾患における脳幹・小脳病変の臨床的特徴

    佐治越爾, 中島章博, 柳川香織, 清水宏, 岡本浩一郎, 柿田明美, 小野寺理, 河内泉

    第33回日本神経免疫学会学術研究集会  2021.10 

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  • Tumefactive demyelinating lesionの臨床免疫病理学的検討

    中島章博, 佐治越爾, 清水宏, 若杉尚宏, 柳村文寛, 柳川香織, 柿田明美, 小野寺理, 河内泉

    第33回日本神経免疫学会学術研究集会  2021.10 

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  • Chronic inflammation and disease progression in multiple sclerosis based on a neuropathological view Invited

    Etsuji Saji, Izumi Kawachi

    第33回日本神経免疫学会学術研究集会  2021.10 

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  • 第5回全国調査からみる多発性硬化症の重症度に寄与する因子の検討

    渡邉充, 磯部紀子, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 河内泉, 越智博文, 中辻裕司, 中村好一, 中村 幸志, 坂田清美, 松井真, 桑原聡, 吉良潤一

    第33回日本神経免疫学会学術研究集会  2021.10 

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  • 希少神経免疫疾患における疾患活動性と妊娠出産管理に関する検討

    栁川香織, 佐治越爾, 中島章博, 村島温子, 小野寺理, 河内泉

    第6回日本母性内科学会総会・学術集会  2021.7 

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  • 医学部入学者選抜システムが2年次医学・看護学合同多職種連携教育に及ぼす影響とその学修効果−再現性の検討

    河内泉, 横野知江, 齋藤あや, 内山美枝子, 住吉智子, 赤石隆夫, 大滝慶樹, 須貝拓朗, 鈴木利哉, 土田正則, 佐藤昇, 染矢俊幸

    第53回 日本医学教育学会大会  2021.7 

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  • Cognitive function and thalamus atrophy in multiple sclerosis and neuromyelitis optica

    Takahiro Wakasugi, Etsuji Saji, Akihiro Nakajima, Fumihiro Yanagimura, Kaori Yanagaw, Masatoyo Nishizwa, Osamu Onodera, Izumi Kawachi

    第62回日本神経学会学術大会  2021.5 

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  • 脊髄肥厚性硬膜炎の病理学的解析

    中島章博, 佐治越爾, 清水宏, 豊島靖子, 岡本浩一郎, 若杉尚宏, 柳村文寛, 柳川香織, 柿田明美, 小野寺理, 河内泉

    第62回日本神経病理学会  2021.5 

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  • LEMSの診断における尺骨神経の電気生理学的評価の有用性

    森秀樹, 今野卓哉, 金澤雅人, 河内泉, 小野寺理

    第62回日本神経学会学術大会  2021.5 

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  • Characterization of spinal hypertrophic pachymeningitis based on immunopathological analysis

    Akihiro Nakajima, Etsuji Saji, Takahiro Wakasugi, Fumihiro Yanagimura, Kaori Yanagawa, Masatoyo Nishizawa, Osamu Onodera, Izumi Kawachi

    第62回日本神経学会学術大会  2021.5 

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  • Management of disease activity and obstetric outcome of pregnancy in a Japanese cohort of MS and NMO

    2021.5 

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  • Autoimmune disease comorbidities in patients with neuromyelitis optica spectrum disorder

    Etsuji Saji, Akihiro Nakajima, Takahiro Wakasugi, Fumihiro Yanagimura, Kaori Yanagawa, Masatoyo Nishizawa, Osamu Onodera, Izumi Kawachi

    第62回日本神経学会学術大会  2021.5 

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  • Prediction of MS disability status in Japanese claims database using principal component analysis

    H. Otaka, K. Ueda, K. Iwasaki, T. Takeshima, I. Kawachi

    MS Virtual 2020. 8th Joint ACTRIMS-ECTRIMS Meeting  2020.12 

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  • ANCA関連脊髄肥厚性硬膜炎の臨床免疫病理学的検討

    中島章博, 佐治越爾, 清水宏, 豊島靖子, 岡本浩一郎, 若杉尚宏, 柳村文寛, 柳川香織, 柿田明美, 小野寺理, 河内泉

    第32回神経免疫学会  2020.10 

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  • 第5回全国調査が示す多発性硬化症・視神経脊髄炎総患者数の増加

    磯部紀子, 新野正明, 松下拓也, 中村優理, 中島一郎, 渡邉充, 酒井康成, 迫田礼子, 中原仁, 河内泉, 越智博文, 中辻裕司, 福元尚子, 林史恵, 中村好一, 中村幸志, 坂田清美, 嶋田莉奈子, 松井真, 吉良潤一

    第32回神経免疫学会  2020.10 

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  • 重症筋無力症合併視神経脊髄炎関連疾患の解析

    佐治越爾, 中島章博, 若杉尚宏, 柳川香織, 小野寺理, 河内泉

    第32回神経免疫学会  2020.10 

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  • 進行性腎細胞癌へのニボルマブ・イピリムマブ併用療法後に生じた自己免疫性脳炎の1例

    小林彩夏, 小出眞悟, 佐治越爾, 山名一寿, 河内泉, 冨田善彦, 小野寺理

    第32回神経免疫学会  2020.10 

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  • 多発性硬化症における大脳萎縮の解析

    若杉 尚宏, 佐治 越爾, 中島 章博, 柳村 文寛, 栁川 香織, 小野寺 理, 河内 泉

    第32回神経免疫学会  2020.10 

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  • Continued increase of multiple sclerosis and neuromyelitis optica and the north-south gradient in Japan; updates from the 5th nationwide survey

    Noriko Isobe, Masaaki Niino, Takuya Matsushita, Yuri Nakamura, Ichiro Nakashima, Mitsuru Watanabe, Yasunari Sakai, Ayako Sakoda, Jin Nakahara, Izumi Kawachi, Hirofumi Ochi, Yuji Nakatsuji, Yusei Miyazaki, Juichi Fujimori, Kenji Kufukihara, Tatsusada Okuno, Shoko Fukumoto, Fumie Hayashi, Kosuke Yonemoto, Ryoji Taira, Yoshikazu Nakamura, Koshi Nakamura, Kiyomi Sakata, Rinako Shimada, Makoto Matsui, Jun-ichi Kira

    MS Virtual 2020. 8th Joint ACTRIMS-ECTRIMS Meeting  2020.9 

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  • Possible role of T-bet and aryl hydrocarbon receptor on lymphocytes in neuromyelitis optica lesions

    柳村 文寛, 佐治 越爾, 若杉 尚宏, 豊島 靖子, 柿田 明美, 高橋 均, 西澤 正豊, 小野寺 理, 河内 泉

    第61回日本神経学会総会  2020.8 

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  • Cerebral lesions and volume in multiple sclerosis and neuromyelitis optica

    若杉 尚宏, 佐治 越爾, 柳村 文寛, 穂苅 万李子, 栁川 香織, 西澤 正豊, 小野寺 理, 河内 泉

    第61回日本神経学会総会  2020.8 

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  • 抗SRP抗体陽性ミオパチーの臨床像

    古山 悠里, 梅田 麻衣子, 梅田 能生, 岸 諒太, 永井 貴大, 秋山 夏葵, 本郷 祥子, 河内 泉, 小宅 睦郎, 藤田 信也

    第61回日本神経学会総会  2020.8 

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  • The clinical and immunological features of NMO patients with onset over 80 years old

    小野 純花, 佐治 越爾, 中島 章博, 若杉 尚宏, 柳村 文寛, 栁川 香織, 西澤 正豊, 小野寺 理, 河内 泉

    第61回日本神経学会総会  2020.8 

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  • Role of disease activity for pregnancy outcome in a Japanese cohort of NMO, MS and MG

    柳川 香織, 穂苅 万季子, 佐治 越爾, 柳村 文寛, 若杉 尚宏, 西澤 正豊, 小野寺 理, 河内 泉

    第61回日本神経学会総会  2020.8 

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  • 医学部入学者選抜システムからみた2年次医学・看護学合同多職種連携教育の効果

    河内泉, 鈴木利哉, 横野知江, 住吉智子, 赤石隆夫, 大滝慶樹, 小山司, 行田正晃, 石津貞二, 武藤唯子, 須貝拓朗, 土田正則, 佐藤昇, 染矢俊幸

    第52回日本医学教育学会大会  2020.7 

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  • コンピテンシー修得度の学生自己評価と医学学修のtipping point

    河内泉, 鈴木利哉, 大滝慶樹, 武藤唯子, 行田正晃, 石津貞二, 小山司, 須貝拓朗, 赤石隆夫, 土田正則, 佐藤昇, 染矢俊幸

    第52回日本医学教育学会大会  2020.7 

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  • Continued increase of multiple sclerosis and neuromyelitis optica in Japan; updates from the 5th nationwide survey

    Jun-ichi Kira, Noriko Isobe, Masaaki Niino, Takuya Matsushita, Yuri Nakamura, Ichiro Nakashima, Mitsuru Watanabe, Yasunari Sakai, Ayako Sakoda, Jin Nakahara, Izumi Kawachi, Hirofumi Ochi, Yuji Nakatsuji, Shoko Fukumoto, Fumie Hayashi, Koichi Nakamura, Koshi Nakamura, Kiyomi Sakata, Rinako Shimada, Makoto Matsui

    The 72th. Annual meeting of the American Academy of Neurology. Virtual. 2020  2020 

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  • 多発性硬化症・視神経脊髄炎関連疾患の全国臨床疫学調査

    中村好一, 坂田清美, 中村幸志, 吉良潤一, 磯部紀子, 酒井康成, 中村優理, 新野正明, 越智博文, 中島一郎, 河内泉, 中原仁, 中辻裕司, 松井真

    2019年度厚生労働省「難治性疾患の継続的な疫学データの収集・解析に関する研究」班会議  2019.12 

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  • Current Healthcare Situation of the Patients with Multiple Sclerosis in Japan Based on Retrospective Claims Database Analysis: Trend over the Disease Course International conference

    H. Otaka, K. Ueda, K. Iwasaki, T. Takeshima, I. Kawachi

    The 12nd Congress of the Pan-Asia Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)  2019.11 

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  • バセドウ氏病の身体所見を欠き、ALS 様の症状を呈した甲状腺中毒性ミオパチーの1例

    登内孝文, 北原匠, 大津裕, 林秀樹, 梅田能生, 梅田麻衣子, 河内泉, 小宅睦郎, 藤田信也

    第145回日本内科学会信越地方会  2019.10 

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  • 脊髄神経根の腫大を呈し、IVIgが有効であった抗MAG抗体関連ニューロパチーの1例

    荻根沢真也, 今野卓哉, 勇亜衣子, 柏木健太, 徳武孝允, 河内泉, 小野寺理

    第145回日本内科学会信越地方会  2019.10 

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  • A 28-year observational study of disease activities in a Japanese cohort of neuromyelitis optica spectrum disorders

    Saji E, Nakajima A, Wakasugi T, Yanagimura F, Yanagawa K, Hokari M, Nshizawa M, Onodera O, Kawachi I

    MULTIPLE SCLEROSIS JOURNAL (The 35th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS))  2019.9 

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  • 本邦における高齢発症視神経脊髄炎の臨床免疫学的特徴 連続73症例の解析から

    中島 章博, 佐治 越爾, 若杉 尚宏, 柳村 文寛, 柳川 香織, 穂苅 万李子, 小野寺 理, 河内 泉

    神経免疫学 (第31回神経免疫学会)  2019.9 

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  • 視神経脊髄炎の病変局所における炎症極性の解析

    柳村 文寛, 佐治 越爾, 若杉 尚宏, 穂苅 万李子, 柳川 香織, 豊島 靖子, 高橋 均, 柿田 明美, 小野寺 理, 河内 泉

    神経免疫学 (第31回神経免疫学会)  2019.9 

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  • 急性脳炎・脳炎 抗GABAB受容体抗体脳炎の臨床的・免疫学的解析

    勇 亜衣子, 坂田 佑輔, 柳村 文寛, 今野 卓哉, 佐治 越爾, 小野寺 理, 河内 泉

    神経免疫学 (第31回神経免疫学会)  2019.9 

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  • 多発性硬化症における認知機能障害と頭部MRIを用いたVBM解析

    若杉 尚宏, 佐治 越爾, 柳村 文寛, 穂苅 万李子, 柳川 香織, 小野寺 理, 河内 泉

    神経免疫学 (第31回神経免疫学会)  2019.9 

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  • 多発性硬化症および視神経脊髄炎患者の臨床的特徴 過去28年間における変遷

    佐治 越爾, 中島 章博, 若杉 尚宏, 柳村 文寛, 柳川 香織, 穂苅 万李子, 小野寺 理, 河内 泉

    神経免疫学 (第31回神経免疫学会)  2019.9 

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  • 持続性部分てんかんで発症しfalse lateralizationを認めた抗GAD抗体陽性脳炎成人例

    坂田 佑輔, 佐治 越爾, 永井 貴大, 渡邉 緑, 柴田 健太郎, 他田 正義, 河内 泉, 小野寺 理

    てんかん研究 (第53回日本てんかん学会)  2019.9 

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  • 視神経脊髄炎における炎症極性の病理学的解析

    柳村文寛, 佐治越爾, 若杉尚宏, 穂苅万李子, 豊島靖子, 高橋均, 柿田明美, 西澤正豊, 小野寺理, 河内泉

    第60回日本神経病理学会  2019.7 

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  • 免疫性神経疾患におけるpreconception careが妊娠と出産に及ぼす影響

    栁川香織, 佐治越爾, 穂苅万李子, 若杉尚宏, 柳村文寛, 小野寺理, 河内泉

    第4回日本母性内科学会総会・学術集会  2019.7 

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  • CSF-derived circulating cell-free DNA as a diagnostic biomarker: learning from a patient with multiphasic tumefactive lesions of the CNS during three years International conference

    Aiko Isami, Izumi Kawachi, Etsuji Saji, Jun Watanabe, Fumihiro Yanagimura, Takahiro Wakasugi, Manabu Natsumeda, Osamu Onodera

    Sendai Conference 2019  2019.6 

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  • 頚椎症が疑われた糖尿病性腕神経根叢障害の1例

    小出眞悟, 上村昌寛, 徳武孝允, 河内泉, 小野寺理

    第144回日本内科学会信越地方会,  2019.6 

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  • Changes of disease activities in NMO spectrum disorders over time – a 28-year observational study

    Etsuji Saji, Takahiro Wakasugi, Fumihiro Yanagimura, Kaori Yanagawa, Mariko Hokari, Masatoyo Nishizawa, Osamu Onodera, Izumi Kawachi

    第60回日本神経学会総会  2019.5 

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  • Disease and pregnancy outcomes in a Japanese cohort of MG, NMO and MS with reproductive histories

    Kaori Yanagawa, Mariko Mariko, Etsuji Saji, Fumihiro Yanagimura, Takahiro Wakasugi, Masatoyo Nishizawa, Osamu Onodera, Izumi Kawachi

    第60回日本神経学会総会  2019.5 

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  • Melanoma cell adhesion molecule on CNS lesions of neuromylitis optica spectrum disorders in situ

    Fumihiro Yanagimura, Etsuji Saji, Takahiro Wakasugi, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Osamu Onodera, Izumi Kawachi

    第60回日本神経学会総会  2019.5 

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  • Analysis of cerebellar symptoms in the CNS autoimmune disorders

    Takahiro Wakasugi, Etsuji Saji, Fumihiro Yanagimura, Mariko Hokari, Kaori Yanagawa, Osamu Onodera, Izumi Kawachi

    第60回日本神経学会総会  2019.5 

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  • Neuroaxonal changes with increased the ion channel TRPM4 in the optic nerves and brain of NMO and MS

    Izumi Kawachi, Mariko Hokari, Etsuji Saji, Kaori Yanagawa, Fumihiro Yanagimura, Takahiro Wakasugi, Yasuko Toyoshima, Hitoshi Takahashi, Akiyoshi Kakita, Masatoyo Nishizawa, Osamu Onodera

    第60回日本神経学会総会  2019.5 

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  • 眼筋症状のみで経過し、発症から8年後に初めて球麻痺症状を呈した抗MuSK抗体陽性重症筋無力症の76歳女性

    北原 匠, 上村 昌寛, 熊谷 航一郎, 柳村 文寛, 中村 航世, 茂木 崇秀, 河内 泉, 小野寺 理

    臨床神経学 (第226回日本神経学会関東地方会)  2019.5 

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  • 多発性硬化症における重症度評価にはどのような尺度を用いるべきか

    内田信彰, 楠進, 桑原聡, 森雅裕, 清水潤, 清水優子, 園生雅弘, 田中正美, 中辻裕司, 新野正明, 河内泉, 野村恭一, 藤原一男, 松尾秀徳, 渡邊修, 松井真

    日本神経学会学術大会プログラム・抄録集 (第60回日本神経学会総会)  2019.5 

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  • 高度の記憶障害と歩行障害を呈し、治療により劇的に改善した抗GABAB受容体抗体脳炎の60歳男性例

    坂田 佑輔, 今野 卓哉, 五十嵐 一也, 浦部 陽香, 徳武 孝允, 野嵜 幸一郎, 河内 泉, 小野寺 理

    臨床神経学 (第227回日本神経学会関東地方会)  2019.4 

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  • 多発性硬化症・視神経脊髄炎関連疾患の臨床疫学調査

    中村幸志, 玉腰暁子, 坂田清美, 中村好一, 吉良潤一, 磯部紀子, 酒井康成, 中村優理, 新野正明, 越智博文, 中島一郎, 河内泉, 中原仁, 中辻裕司, 松井真

    2018年度厚生労働省「難治性疾患の継続的な疫学データの収集・解析に関する研究」班会議  2018.12 

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  • 肥厚性硬膜炎の重症度分類

    KAWACHI Izumi

    厚生労働科学研究費補助金(難治性疾患等政策研究事業(難治性疾患政策研究事業))「IgG4関連疾患の診断基準ならびに治療指針の確立を目指す研究」 2018年度第3回岡崎班 内分泌神経領域分科会  2018.12 

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  • Efficacy of Dimethyl Fumarate in Japanese MS Patient in Phase 3 APEX Study and the Open Label Extension Study: 72 weeks Interim Analysis International conference

    T. Kondo, I. Kawachi, Y. Onizuka, K. Hiramatsu, M. Hase, J. Yun, S. Torii

    The 6th Congress of the Pan-Asia Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)  2018.11 

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  • 免疫チェックポイント阻害剤であるニボルマブ投与後に,高CK血症を伴う重症筋無力症を発症した1例

    内山純花, 勇亜衣子, 島岡雄一, 林秀樹, 大津裕, 梅田能生, 梅田麻衣子, 河内泉, 小宅睦郎, 藤田信也

    第143回日本内科学会信越地方会  2018.10 

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  • 細菌性髄膜脳炎の鑑別を要したセフトリアキソン脳症の1例

    中島章博, 須貝章弘, 畠野雄也, 河内泉, 小野寺理

    第143回日本内科学会信越地方会  2018.10 

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  • 病理学的に同定した進行性の白質病変を認めた脳アミロイドβ関連血管炎の2症例

    北原匠, 上村昌博, 柳村文博, 畠野雄也, 須貝章弘, 河内泉, 柿田明美, 小野寺理

    Dementia Japan (第37回日本認知症学会学術集会)  2018.9 

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  • 視神経脊髄炎におけるmelanoma cell adhesion moleculeの病理学的検討

    柳村文寛, 佐治越爾, 若杉尚宏, 穂苅万李子, 柳川香織, 豊島靖子, 柿田明美, 高橋均, 小野寺理, 河内泉

    Neuroimmunology (第30回神経免疫学会)  2018.9 

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  • Cortical midline structuresを主病変とする抗GAD抗体関連自己免疫性脳炎の1例

    坂田佑輔, 佐治越爾, 永井貴大, 渡邉緑, 柴田健太郎, 他田正義, 河内泉, 小野寺理

    Neuroimmunology (第30回神経免疫学会)  2018.9 

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  • 多発性硬化症の縦断的認知機能動態とQOLの解析

    若杉尚宏, 佐治越爾, 柳村文寛, 穂苅万李子, 柳川香織, 小野寺理, 河内泉

    Neuroimmunology (第30回神経免疫学会)  2018.9 

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  • Neuromyelitis opticaにおけるTRPM4分子発現動態の解析

    穂苅万李子, 佐治越爾, 柳村文寛, 若杉尚宏, 柳川香織, 豊島靖子, 柿田明美, 小野寺理, 西澤正豊, 河内泉

    Neuroimmunology (第30回神経免疫学会)  2018.9 

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  • Radiological, immunological, and pathological analysis of ependymal cells in neuromyelitis spectrum disorders International conference

    Yanagimura Fumihiro, Saji Etsuji, Wakasugi Takahiro, Toyoshima Yasuko, Kakita Akiyoshi, Takahashi Hitoshi, Onodera Osamu, Kawachi Izumi

    BRAIN PATHOLOGY (第59回日本神経病理学会, 東京, 2018年. 19th International Congress of Neuropathology (ICN2018))  2018.9 

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  • 視神経脊髄炎関連疾患におけるジェンダー効果の解析

    佐治越爾, 中島章博, 若杉尚宏, 柳村文寛, 柳川香織, 小野寺理, 河内泉

    Neuroimmunology (第30回神経免疫学会)  2018.9 

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  • Clinical, radiological and immunological features of late-onset neuromyelitis optica spectrum disorders in a Japan cohort

    Akihiro Nakajima, Etsuji Saji, Takahiro Wakasugi, Fumihiro Yanagimura, Kaori Yanagawa, Osamu Onodera, Izumi Kawachi

    第59回日本神経学会総会  2018.5 

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  • Transient eosinophilia following initiation of dimethyl fumarate in multiple sclerosis

    Fumihiro Yanagimura, Etsuji Saji, Takahiro Wakasugi, Osamu Onodera, Izumi Kawachi

    第59回日本神経学会総会  2018.5 

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  • A longitudinal study of cognitive function in the CNS autoimmune disorders

    Takahiro Wakasugi, Etsuji Saji, Fumihiro Yanagimura, Masatoyo Nishizawa, Osamu Onodera, Izumi Kawachi

    第59回日本神経学会総会  2018.5 

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  • Validation of proposed diagnostic criteria and severity classification for idiopathic hypertrophic pachymeningitis

    Etsuji Saji, Akiko Yokoseki, Takahiro Wakasugi, Fumihiro Yanagimura, Kaori Yanagawa, Masatoyo Nishizawa, Osamu Onodera, Izumi Kawachi

    第59回日本神経学会総会  2018.5 

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  • A family with leukoencephalopathy carrying COX10 mutation and deletion of PMP22: clinical analysis

    Yasuko Kuroha, Takanobu Ishiguro, Arika Hasegawa, Takashi Tani, Tetsuya Takahashi, Nae Matsubara, Mari Tada, Izumi Kawachi, Akiyoshi Kakita, Osamu Onodera, Takeshi Ikeuchi, Ryoko Koike

    第59回日本神経学会総会  2018.5 

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  • A family with leukoencephalopathy carrying COX10 mutation and deletion of PMP22: Genetic analysis

    Takanobu Ishiguro, Yasuko Kuroha, Norikazu Hara, Naomi Mezaki, Takeshi Miura, Kensaku Kasuga, Arika Hasegawa, Takashi Tani, Tetsuya Takahashi, Nae Matsubara, Mari Tada, Izumi Kawachi, Akiyoshi Kakita, Osamu Onodera, Ryoko Koike, Takeshi Ikeuchi

    第59回日本神経学会総会  2018.5 

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  • 三叉神経節から脊髄路核までMRIで造影効果を伴う病変を認め,バラシクロビルが奏功した38歳男性例

    加藤怜, 須貝章弘, 山岸拓磨, 他田正義, 河内泉, 小野寺理

    臨床神経学 (第223回日本神経学会関東地方会)  2018 

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  • T2<sup>*</sup>強調画像で微小出血を認めず,軟髄膜病変が急速に拡大したアミロイドβ関連血管炎の75歳女性例

    畠野雄也, 須貝章弘, 山岸宅磨, 中島章博, 他田正義, 河内泉, 小野寺理

    臨床神経学 (第224回日本神経学会関東地方会)  2018 

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  • 日本人RRMS患者に対するフマル酸ジメチルの有効性;APEX 試験中間解析より

    近藤誉之, 河内泉, 鬼塚康弘, 平松且稔, 長谷昌知, Jang Yun, Yan Ling, 鳥居慎一

    第35回日本神経治療学会  2017.11 

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  • 有痛性筋痙攣に対して免疫グロブリン静注療法が有効であった筋萎縮性側索硬化症の1例

    茂木崇秀, 石原智彦, 他田正義, 河内泉, 下畑享良, 小野寺理

    第35回日本神経治療学会  2017.11 

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  • Differential dynamics of mucosal-associated invariant T cells in the blood and the CNS lesions of patients with neuromyelitis optica

    Fumihiro Yanagimura, Etsuji Saji, Takahiro Wakasugi, Mariko Hokari, Osamu Onodera, Izumi Kawachi

    第47回日本免疫学会  2017.11 

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  • Useful scales for recognition of severe disease status in patients with multiple sclerosis in Japan

    Matsui M, Uchida N, Kawai U, Kusunoki S, Kuwabara S, Mori M, Shimizu J, Shimizu Y, Sonoo M, Tanaka M, Nakatsuji Y, Niino M, Kawachi I, Nomra K, Fujihara K, Matsuo H, Watanabe O

    JOURNAL OF THE NEUROLOGICAL SCIENCES (The XXIII World Congress of Neurology, Kyoto, Japan)  2017.10 

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  • Efficacy of delayed-release dimethyl fumarate in Japanese patients with relapsing multiple sclerosis in the placebo-controlled phase 3 apex study

    Kondo T, Kawachi I, Onizuka Y, Hiramatsu K, Hase M, Yun J, Ling Y, Torii S

    JOURNAL OF THE NEUROLOGICAL SCIENCES (The XXIII World Congress of Neurology, Kyoto, Japan)  2017.10 

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  • Clinical and genetic features of Japanese patients with multiple sclerosis and neuromyelitis optica spectrum disorder based on Japan multiple sclerosis biobank

    Matsushita T, Nakamura Y, Niino M, Fukaura H, Tanaka M, Ohi H, Kanda T, Yokota T, Matsui M, Kusunoki S, Terayama Y, Kawachi I, Ohashi T, Shimohama S, Nishiyama K, Nakatsuji Y, Suzumura A, Ohi K, Yamamoto K, Yamasaki R, Kawano Y, Tsuji S, Hinomura A, Tada M, Matsuyama A, Shimizu Y, Nagaishi A, Okada K, Shinoda K, Isobe N, Kira J. I

    JOURNAL OF THE NEUROLOGICAL SCIENCES (The XXIII World Congress of Neurology, Kyoto, Japan)  2017.10 

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  • 肺炎球菌ワクチン接種後に発症した非典型的ギラン・バレー症候群の1例

    荻根沢真也, 山岸拓磨, 佐治越爾, 河内泉, 小野寺理

    第141回日本内科学会信越地方会  2017.10 

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  • 再発性胸腺腫術後に腹壁の難治性疼痛を呈した重症筋無力症の44歳男性例

    山岸拓磨, 佐治越爾, 荻根沢真也, 安藤昭一郎, 茂木崇秀, 他田正義, 河内泉, 小野寺理

    Neuroimmunology (第29回神経免疫学会)  2017.9 

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  • Recommendations for the management of neuro-Behcet’s disease by the Japanese national research committee for Behcet’s disease International conference

    Hirotoshi Kikuchi, Tetsuji Sawada, Masato Okada, Mitsuhiro Takeno, Masataka Kuwana, Yoshiaki Ishigatsubo, Izumi Kawachi, Hideki Mochizuki, Susumu Kusunoki, Shunsei Hirohata

    JOURNAL OF THE NEUROLOGICAL SCIENCES (The XXIII World Congress of Neurology, Kyoto, Japan)  2017.9 

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  • 診断基準・重症度分類作成に向けた肥厚性硬膜炎の臨床的・免疫学的解析

    佐治越爾, 横関明子, 若杉尚宏, 柳村文寛, 穂苅万李子, 柳川香織, 西澤正豊, 小野寺理, 河内泉

    Neuroimmunology (第29回神経免疫学会)  2017.9 

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  • 視神経脊髄炎における脳室上衣の免疫学的・病理学的検討

    柳村文寛, 佐治越爾, 穂苅万李子, 若杉尚宏, 豊島靖子, 柿田明美, 高橋均, 西澤正豊, 小野寺理, 河内泉

    Neuroimmunology (第29回神経免疫学会)  2017.9 

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  • 自己免疫性脳炎の臨床的・免疫学的・放射線学的特徴の解析

    若杉尚宏, 佐治越爾, 柳村文寛, 穂苅万李子, 柳川香織, 西澤正豊, 小野寺理, 河内泉

    Neuroimmunology (第29回神経免疫学会)  2017.9 

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  • Real World Question (RWQ) for Better Practical MS Treatment

    河内泉, 中島一郎, 野原千洋子, 宮本勝一, 横山和正

    Neuroimmunology (第29回神経免疫学会)  2017.9 

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  • Efficacy of Dimethyl Fumarate in Japanese MS Patients: Interim Analysis of the APEX Extension Study

    Takayuki Kondo, Izumi Kawachi, Yasuhiro Onizuka, Katsutoshi Hiramatsu, Masakazu Hase, Jang Yun, Yan Ling, Shinichi Torii

    Neuroimmunology (第29回神経免疫学会)  2017.9 

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  • Improvement of cognitive impairment in an MS patient with fingolimod treatment for 7 years

    Takahiro Wakasugi, Etusji SAJI, Fumihiro YANAGIMURA, Mariko HOKARI, Kaori YANAGAWA, Masatoyo NISHIZAWA, Osamu ONODERA, Izumi KAWACHI

    The 4th MS Summer College in Kobe,  2017.8 

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  • Unique patterns of clinical course and neurodegeneration in NMOSD

    Fumihiro Yanagimura, Takahiro Wakasugi, Etsuji Saji, Mariko Hokari, Masatoyo Nishizawa, Osamu Onodera, Izumi Kawachi

    Sendai Conference 2017  2017.7 

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  • 視神経脊髄炎病変局所におけるFOXP3+ regulatory T cellsの解析

    柳村文寛, 佐治越爾, 穂苅万李子, 豊島靖子, 柿田明美, 高橋均, 小野寺理, 西澤正豊, 河内泉

    第58回日本神経病理学会  2017.6 

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  • 単下肢失調を呈した多発性硬化症の30歳女性例

    井上佳奈, 大原浩司, 茂木崇秀, 佐治越爾, 他田正義, 河内泉, 下畑享良, 小野寺理

    臨床神経学 (第220回日本神経学会関東地方会)  2017.3 

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  • PREVALENCE AND PATIENT CHARACTERISTICS OF MULTIPLE SCLEROSIS (MS) IN JAPAN

    Ogino M, Shiozawa A, Ohta H, Okamoto S, Hiroi S, Otake K, Takeshima T, Iwasaki K, Kawachi I

    VALUE IN HEALTH (ISPOR 7th Asia-Pacific Conference)  2016.11 

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  • 視神経脊髄炎におけるtissue Tregs動態の検討

    柳村文寛, 佐治越爾, 穂苅万李子, 柳川香織, 豊島靖子, 柿田明美, 高橋均, 小野寺理, 西澤正豊, 河内泉

    Neuroimmunology (第28回神経免疫学会)  2016.9 

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  • 重症帯状疱疹のためフィンゴリモド一時中断に伴いbreakthrough disease様の進展を来した多発性硬化症の一例

    大津裕, 佐治越爾, 柳村文寛, 穂苅万李子, 若杉尚宏, 柳川香織, 西澤正豊, 河内泉, 小野寺理

    Neuroimmunology (第28回神経免疫学会)  2016.9 

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  • Neuromyelitis optica脳病変における神経放射線学的・神経病理学的特徴

    穂刈万李子, 佐治越爾, 柳村文寛, 柳川香織, 豊島靖子, 柿田明美, 高橋均, 小野寺理, 西澤正豊, 河内泉

    Neuroimmunology (第28回神経免疫学会)  2016.9 

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  • 眼窩炎症性偽腫瘍における髄液サイトカイン・ケモカインの検討

    佐治越爾, 西田茉那, 柳村文寛, 穂苅万李子, 若杉尚宏, 柳川香織, 小野寺理, 西澤正豊, 河内泉

    Neuroimmunology (第28回神経免疫学会)  2016.9 

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  • Management of severe varicella-zoster virus infections and rebounds of disease activity in MS patients with fingolimod treatment International conference

    Etusji SAJI, Shigeki NANASAWA, Yutaka Otsu, Fumihiro YANAGIMURA, Mariko HOKARI, Kaori YANAGAWA, Osamu ONODERA, Masatoyo NISHIZAWA, Izumi KAWACHI

    Sendai Conference 2016  2016.7 

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  • Severe neurodegeneration with abnormal accumulation of degenerative mitochondria in the anterior visual pathway of neuromyelitis optica International conference

    Fumihiro Yanagimura, Mariko Hokari, Akiko Yokoseki, Musashi Arakawa, Etsuji Saji, Kaori Yanagawa, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Osamu Onodera, Masatoyo Nishizawa, Izumi Kawachi

    Sendai Conference 2016  2016.7 

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  • Dynamics of axonal mitochondria in neuromyelitis optica

    穂苅万李子, 佐治越爾, 横関明子, 柳川香織, 柳村文寛, 荒川武蔵, 豊島靖子, 柿田明美, 高橋均, 西澤正豊, 河内泉

    第57回日本神経病理学会  2016.6 

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  • Clinical, radiological and immunological features of idiopathic hypertrophic pachymeningitis

    Izumi Kawachi, Akiko Yokoseki, Etsuji Saji, Mariko Hokari, Fumihiro Yanagimura, Kaori Yanagawa, Masatoyo Nishizawa

    第57回日本神経学会総会  2016.5 

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  • Cost and treatment patterns for multiple sclerosis based on a health insurance claims database

    Mieko Ogino, Izumi Kawachi, Kazuyoshi Otake, Hiroyuki Ohta, Tomomi Takeshima, Kosuke Iwasaki, Shinzo Hiroi

    第57回日本神経学会総会  2016.5 

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  • Clinical profiles of orbital inflammatory pseudotumors with neurological involvement

    Mana Takahashi, Etsuji Saji, Mariko Hokari, Akiko Yokoseki, Fumihiro Yanagimura, Kaori Yanagawa, Masatoyo Nishizawa, Izumi Kawachi

    第57回日本神経学会総会  2016.5 

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  • The neuroradiological and immunological analysis of neuro-Behçet's disease

    Fumihiro Yanagimura, Etsuji Saji, Mariko Hokari, Kaori Yanagawa, Akiko Yokoseki, Masatoyo Nishizawa, Izumi Kawachi

    第57回日本神経学会総会  2016.5 

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  • NMO is characterized by serious attacks and neurodegeneration with abnormal mitochondria

    Mariko Hokari, Akiko Yokoseki, Musashi Arakawa, Etsuji Saji, Kaori Yanagawa, Fumihiro Yanagimura, Yasuko Toyoshima, Kouichirou Okamoto, Satoshi Ueki, Tetsuhisa Hatase, Riuko Ohashi, Takeo Fukuchi, Kohei Akazawa, Mitsunori Yamada, Akiyoshi Kakita, Hitoshi Takahashi, Osamu Onodera, Masatoyo Nishizawa, Izumi Kawachi

    第57回日本神経学会総会  2016.5 

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  • Analysis of neurodegeneration with astrocytopathy in neuromyelitis optica and multiple sclerosis

    Mariko Hokari, Akiko Yokoseki, Etsuji Saji, Musashi Arakawa, Kaori Yanagawa, Fumihiro Yanagimura, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    第57回日本神経学会総会  2016.5 

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  • Ectopic lymphoid neogenesis in ANCA-associated vasculitis

    Mariko Hokari, Etsuji Saji, Fumihiro Yanagimura, Akiko Yokoseki, Kaori Yanagawa, Masatoyo Nishizawa, Izumi Kawachi

    第45回日本免疫学会  2015.11 

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  • レセプトデータを活用した我が国の多発性硬化症の治療実態及び医療費分析

    荻野美恵子, 河内泉, 河内泉, 大竹一嘉, 太田浩之, 大塚裕次郎, 岩崎宏介, 廣居伸蔵

    Neuroimmunology (第27回神経免疫学会)  2015.9 

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  • 炎症性脱髄病変の併発が疑われたT3271C変異MELASの一例

    石黒舞乃, 佐治越爾, 矢島隆二, 樋口陽, 石川正典, 関根有美, 下畑享良, 西澤正豊, 河内泉

    Neuroimmunology (第27回神経免疫学会)  2015.9 

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  • 視神経脊髄炎における抗ミトコンドリア抗体の検討

    穂苅万李子, 佐治越爾, 柳村文寛, 柳川香織, 横関明子, 西澤正豊, 河内泉

    Neuroimmunology (第27回神経免疫学会)  2015.9 

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  • 神経Behcet’s病の脳脊髄液サイトカイン・ケモカインの解析

    柳村文寛, 佐治越爾, 穂苅万李子, 柳川香織, 横関明子, 西澤正豊, 河内泉

    Neuroimmunology (第27回神経免疫学会)  2015.9 

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  • 中枢神経系自己免疫疾患における神経変性の解析

    穂苅万李子, 佐治越爾, 横関明子, 荒川武蔵, 豊島靖子, 柿田明美, 高橋均, 西澤正豊, 河内泉

    第56回日本神経病理学会  2015.6 

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  • クリプトコッカス髄膜脳炎を発症した全身型重症筋無力症の67歳男性例

    石黒敬信, 堅田慎一, 山田舞乃, 金澤雅人, 高橋哲哉, 河内泉, 下畑享良, 西澤正豊

    第136回日本内科学会信越地方会  2015.6 

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  • 多彩な臨床像と画像所見を呈する抗アクアポリン4抗体関連疾患

    梅田麻衣子, 梅田能生, 笠原壮, 今野卓哉, 柳村文寛, 河内泉, 小宅睦郎, 藤田信也

    第56回日本神経学会総会  2015.5 

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  • Clinicopathological features of anterior visual pathway involvement in NMO

    Mariko Hokari, Izumi Kawachi, Akiko Yokoseki, Etsuji Saji, Musashi Arakawa, Kaori Yanagawa, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa

    第56回日本神経学会総会  2015.5 

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  • Predominance of MPO-ANCA-positivity in hypertrophic pachymeningitis in Japan

    Izumi Kawachi, Akiko Yokoseki, Etsuji Saji, Mariko Hokari, Masatoyo Nishizawa

    第56回日本神経学会総会  2015.5 

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  • Cortical neurodegeneration with meningeal inflammation in neuromyelitis optica and multiple sclerosis

    Mariko Hokari, Etsuji Saji, Akiko Yokoseki, Kaori Yanagawa, Masatoyo Nishizawa, Izumi Kawachi

    第44回日本免疫学会  2014.12 

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  • 重症筋無力症に対し胸腺摘出後脊髄長大病変を来した21歳女性例

    宇津見宏太, 酒井直子, 眞島卓弥, 春日健作, 野崎洋明, 河内泉, 西澤正豊

    臨床神経学 (第209回日本神経学会関東地方会)  2014.10 

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