Updated on 2024/05/19

写真a

 
FUJIMURA Koji
 
Organization
Academic Assembly Institute of Science and Technology CHIKYU SEIBUTSU KAGAKU KEIRETU Assistant Professor
Faculty of Science Department of Science Assistant Professor
Title
Assistant Professor
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Degree

  • 博士(理学) ( 2007.9   東京工業大学 )

  • 修士(理学) ( 2003.3   東京工業大学 )

  • Bachelor of Science ( 2001.3   Tokyo Institute of Technology )

Research Interests

  • bone

  • Morphology

  • geometric morphometric

  • fish

  • Genetics

  • 発生

  • diversity

  • 進化

  • respiratory organ

  • 遺伝

  • Polypterus

  • 形態

  • Evolution

  • tilapia

  • cichlid

  • evo-devo

  • head

  • Nile Tilapia

  • jaw

  • Development

Research Areas

  • Life Science / Evolutionary biology

  • Life Science / Developmental biology

Research History (researchmap)

  • Niigata University   Departmen of Science, Faculty of Science   Assistant Professor

    2017.4

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  • Niigata University   Department of Environmental Science, Faculty of Science   Assistant Professor

    2013.9 - 2017.3

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  • Jikei University   Department of Anatomy   JSPS Postdoctoral Fellow

    2011.4 - 2013.8

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  • University of Maryland   Department of Biology   Research Associate

    2008.9 - 2011.3

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  • Tokyo Institute of Technology   Graduate School of Bioscience and Biotechnology   Postdoctoral Researcher

    2008.1 - 2008.8

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  • Tokyo Institute of Technology   Postdoctoral Researcher

    2007.10 - 2007.12

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  • Tokyo Institute of Technology   Graduate School of Bioscience and Biotechnology   JSPS Predoctoral Fellow (DC2, millennium)

    2004.4 - 2005.3

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Research History

  • Niigata University   Faculty of Science Department of Science   Assistant Professor

    2017.4

  • Niigata University   Abolition organization Environmental Biology   Assistant Professor

    2013.9 - 2017.3

Education

  • 東京工業大学大学院   生命理工学研究科   生体システム専攻

    2003.4 - 2007.9

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    Country: Japan

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  • 東京工業大学大学院   生命理工学研究科   生体システム専攻

    2001.4 - 2003.3

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    Country: Japan

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  • Tokyo Institute of Technology   School of Bioscience and Biotechnology   生体機構学科

    1997.4 - 2001.3

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    Country: Japan

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Professional Memberships

  • SOCIETY OF EVOLUTIONARY STUDIES, JAPAN

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  • JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS

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  • THE ZOOLOGICAL SOCIETY OF JAPAN

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  • European society for Evolutionary Developmental biology

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  • Society for Integrative & Comparative Biology

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  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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Committee Memberships

  • 国際生物学オリンピック2020 長崎大会   理論問題(進化部門)作題委員  

    2019.4 - 2020.9   

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  • 日本動物学会   第86回大会実行委員会 実行委員  

    2013.9 - 2015.9   

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    Committee type:Academic society

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Papers

  • Water properties and quality of the largest rice production region in Japan and their influence on the reproduction of zebrafish Reviewed

    Koji Fujimura, Ayane Shima

    Environmental Science and Pollution Research   2024

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s11356-024-32597-3

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    Other Link: https://link.springer.com/article/10.1007/s11356-024-32597-3/fulltext.html

  • The involvement of Nile tilapia (Oreochromis niloticus) Neu4 sialidase in neural differentiation during early ontogenesis Reviewed International journal

    Akinobu Honda, Oki Hayasaka, Kenjiro Mio, Koji Fujimura, Tomonari Kotani, Masaharu Komatsu, Kazuhiro Shiozaki

    Biochimie   185   105 - 116   2021.6

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    Neurogenesis is an important process for the formation of the central nervous system during ontogenesis. Mammalian sialidases are involved in neurogenesis through desialylation of sialo-glycoconjugates. However, the significance of fish sialidases, unlike that of mammals, in neurogenesis has not been investigated. The present study focuses on Nile tilapia (Oreochromis niloticus) because of its unique profiles of sialidases related to enzymatic properties, subcellular localization, and tissue-specific gene expression. First, the fish were cultured under aphotic condition, which is known to cause the delayed development of the retina and brain in various fish. Next, we investigate the effect of aphotic condition on the levels of tilapia sialidases. Our results revealed that the tilapia showed a decrease in the number of ganglion cell in the retina. The expression level of neu4 mRNA is up-regulated in the eyes from tilapia reared in Dark accompanied by the increase of retinal differentiation markers. These results indicated that tilapia Neu4 is involved in retinal development in Nile tilapia. Furthermore, we tried to clarify the function of tilapia Neu4 in the neuronal cells using two neuroblast cell lines (SH-SY5Y and Neuro2a cell lines). Tilapia Neu4 decreased sialic acid level of both nuclear glycoproteins as well as glycolipids. Moreover, tilapia Neu4 accelerated neurite formation in both two neural cell lines and, increased the acetylcholinesterase activity, but it did not affect cell proliferation. Collectively, these results suggest that Neu4 accelerates neurite differentiation during ontogenesis in tilapia.

    DOI: 10.1016/j.biochi.2021.03.008

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  • Novel Nile tilapia Neu1 sialidases: Molecular cloning and biochemical characterization of the sialidases Neu1a and Neu1b Reviewed International journal

    Akinobu Honda, Petros Kingstone Chigwechokha, Ryo Takase, Oki Hayasaka, Koji Fujimura, Tomonari Kotani, Masaharu Komatsu, Kazuhiro Shiozaki

    Gene   742   144538 - 144538   2020.6

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    Lysosomal desialylation is the initial step in the degradation of sialo-glycopeptides that is essential for regenerating sialo-glycoconjugates. Neu1 sialidase is the enzyme responsible for the removal of sialic acid in the mammalian lysosome. Although Neu1 sialidases are conserved in fish similar to mammals, their physiological functions remain to be fully understood. Nile tilapia (Oreochromis niloticus) is known to possess two putative Neu1 sialidases (Neu1a and Neu1b) in the genome that may have arisen by gene duplication (specifically in cichlidae family members). This suggests that understanding the Neu1 sialidase in fish, particularly cichlids, could provide insights into the (novel) physiological functions of these genes. Moreover, characterization of the tilapia Neu1 sialidase is paramount to ensure clarity of the desialylation reaction performed by the fish sialidases (like the characterized tilapia sialidases Neu3 and Neu4). Therefore, this study focused on the characterization of the tilapia Neu1 sialidases. Neu1b exhibited narrow substrate specificity when compared with Neu1a, whereas the properties of these two Neu1 sialidases, such as cathepsin A-induced activation, optimal pH, and lysosomal localization, were conserved. Neu1a mRNA levels were detected in various tissues of tilapia as compared to the mRNA levels of Neu1b. Although the cloned construct of Neu1b contained an extra exon unlike tilapia Neu1a, the exon did not affect the enzymatic properties of Neu1b. This study suggests that tilapia Neu1a profiles were highly conserved with other vertebrate Neu1 isoforms, while Neu1b probably evolved independently in other members of the cichlidae family. Moreover, the expression of sialidase genes (neu1a, neu1b, neu3a, and neu4) were determined in various stages of tilapia embryogenesis using real-time PCR; sialidase gene expression is reported to be drastically and individually altered during embryogenesis in Japanese medaka (Oryzias latipes). The mRNA levels of neu1a drastically increased between 72 and 84 hpf and mildly decreased from 84 to 144 hpf. In contrast, the transcript levels of neu1b did not change between 84 and 144 hpf and the expression of neu3a gradually increased between 84 and 120 hpf and drastically decreased at 144 hpf. The highest level of the neu4 transcripts was detected at 84 hpf. These expression patterns were different from those in Japanese medaka, possibly due to the different developmental program found in the tilapia embryo accompanied with the unique profiles of the tilapia sialidases.

    DOI: 10.1016/j.gene.2020.144538

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  • Molecular developmental mechanism in polypterid fish provides insight into the origin of vertebrate lungs Reviewed

    Norifumi Tatsumi, Ritsuko Kobayashi, Tohru Yano, Masatsugu Noda, Koji Fujimura, Norihiro Okada, Masataka Okabe

    SCIENTIFIC REPORTS   6   30580   2016.7

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    The lung is an important organ for air breathing in tetrapods and originated well before the terrestrialization of vertebrates. Therefore, to better understand lung evolution, we investigated lung development in the extant basal actinopterygian fish Senegal bichir (Polypterus senegalus). First, we histologically confirmed that lung development in this species is very similar to that of tetrapods. We also found that the mesenchymal expression patterns of three genes that are known to play important roles in early lung development in tetrapods (Fgf10, Tbx4, and Tbx5) were quite similar to those of tetrapods. Moreover, we found a Tbx4 core lung mesenchyme-specific enhancer (C-LME) in the genomes of bichir and coelacanth (Latimeria chalumnae) and experimentally confirmed that these were functional in tetrapods. These findings provide the first molecular evidence that the developmental program for lung was already established in the common ancestor of actinopterygians and sarcopterygians.

    DOI: 10.1038/srep30580

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  • Development of the lateral plate mesoderm in medaka Oryzias latipes and Nile tilapia Oreochromis niloticus: insight into the diversification of pelvic fin position Reviewed

    Hiroki Kaneko, Yuki Nakatani, Koji Fujimura, Mikiko Tanaka

    JOURNAL OF ANATOMY   225 ( 6 )   659 - 674   2014.12

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    The position of the pelvic fins among teleost fishes has tended to shift rostrally during evolution. This positional shift seems to have led to the diversification of feeding behavior and allowed adaptation to new environments. To understand the developmental basis of this shift in pelvic fin position among teleosts, we investigated the embryonic development of the lateral plate mesoderm, which gives rise to the pelvic fins, at histological levels in the medaka Oryzias latipes (abdominal pelvic fins) and Nile tilapia Oreochromis niloticus (thoracic pelvic fins). Our histological analyses revealed that the lateral plate mesodermal cells expand not only ventrally but also rostrally to cover the yolk during embryogenesis of both medaka and Nile tilapia. In medaka, we also found that the lateral plate mesoderm completely covered the yolk prior to the initiation of the pelvic fin buds, whereas in Nile tilapia the pelvic fin buds appeared in the body wall from the lateral plate mesoderm at the thoracic level when the lateral plate mesodermal cells only covered one-third of the yolk. We discuss the relevance of such differences in the rate of the lateral plate mesoderm expansion on the yolk surface and the position of the pelvic fins.

    DOI: 10.1111/joa.12244

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  • Coelacanth genomes reveal signatures for evolutionary transition from water to land Reviewed

    Masato Nikaido, Hideki Noguchi, Hidenori Nishihara, Atsushi Toyoda, Yutaka Suzuki, Rei Kajitani, Hikoyu Suzuki, Miki Okuno, Mitsuto Aibara, Benjamin P. Ngatunga, Semvua I. Mzighani, Hassan W.J. Kalombo, Kawilarang W.A. Masengi, Josef Tuda, Sadao Nogami, Ryuichiro Maeda, Masamitsu Iwata, Yoshitaka Abe, Koji Fujimura, Masataka Okabe, Takanori Amano, Akiteru Maeno, Toshihiko Shiroishi, Takehiko Itoh, Sumio Sugano, Yuji Kohara, Asao Fujiyama, Norihiro Okada

    Genome Research   23 ( 10 )   1740 - 1748   2013.10

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    Coelacanths are known as ''living fossils,'' as they show remarkable morphological resemblance to the fossil record and belong to the most primitive lineage of living Sarcopterygii (lobe-finned fishes and tetrapods). Coelacanths may be key to elucidating the tempo and mode of evolution from fish to tetrapods. Here, we report the genome sequences of five coelacanths, including four Latimeria chalumnae individuals (three specimens from Tanzania and one from Comoros) and one L. menadoensis individual from Indonesia. These sequences cover two African breeding populations and two known extant coelacanth species. The genome is ~2.74 Gbp and contains a high proportion (~60%) of repetitive elements. The genetic diversity among the individuals was extremely low, suggesting a small population size and/or a slow rate of evolution. We found a substantial number of genes that encode olfactory and pheromone receptors with features characteristic of tetrapod receptors for the detection of airborne ligands. We also found that limb enhancers of bmp7 and gli3, both of which are essential for limb formation, are conserved between coelacanth and tetrapods, but not ray-finned fishes. We expect that some tetrapod-like genes may have existed early in the evolution of primitive Sarcopterygii and were later co-opted to adapt to terrestrial environments. These coelacanth genomes will provide a cornerstone for studies to elucidate how ancestral aquatic vertebrates evolved into terrestrial animals. © 2013, Published by Cold Spring Harbor Laboratory Press.

    DOI: 10.1101/gr.158105.113

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  • Circular DNA Intermediate in the Duplication of Nile Tilapia vasa Genes Reviewed

    Koji Fujimura, Matthew A. Conte, Thomas D. Kocher

    PLOS ONE   6 ( 12 )   e29477   2011.12

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    vasa is a highly conserved RNA helicase involved in animal germ cell development. Among vertebrate species, it is typically present as a single copy per genome. Here we report the isolation and sequencing of BAC clones for Nile tilapia vasa genes. Contrary to a previous report that Nile tilapia have a single copy of the vasa gene, we find evidence for at least three vasa gene loci. The vasa gene locus was duplicated from the original site and integrated into two distant novel sites. For one of these insertions we find evidence that the duplication was mediated by a circular DNA intermediate. This mechanism of gene duplication may explain the origin of isolated gene duplicates during the evolution of fish genomes. These data provide a foundation for studying the role of multiple vasa genes in the development of tilapia gonads, and will contribute to investigations of the molecular mechanisms of sex determination and evolution in cichlid fishes.

    DOI: 10.1371/journal.pone.0029477

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  • Tol2-mediated transgenesis in tilapia (Oreochromis niloticus) Reviewed

    Koji Fujimura, Thomas D. Kocher

    AQUACULTURE   319 ( 3-4 )   342 - 346   2011.10

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    The Nile tilapia (Oreochromis niloticus) is an important species in aquaculture and an excellent model system for laboratory studies. Functional genetic analysis using this species has been difficult because existing methods for producing transgenics are inefficient. Here we show that the Tol2 transposon system can be used to create transgenic tilapia with high efficiency. We constructed a line that is transgenic for GFP under control of a Xenopus elongation factor 1 alpha. (EF1 alpha) promoter. The germline transmission rate of the Tol2 construct to the first generation was about 30%, which is much higher than conventional methods. GFP expression was strong and ubiquitous in the embryos. Application of the Tol2 system for constructing transgenics in tilapia and related species will promote research in many areas, but will be especially useful for studies of evolutionary developmental biology in the cichlid fishes of East Africa. (C) 2011 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.aquaculture.2011.07.021

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  • Allometric growth of the trunk leads to the rostral shift of the pelvic fin in teleost fishes Reviewed

    Yumie Murata, Mika Tamura, Yusuke Aita, Koji Fujimura, Yasunori Murakami, Masataka Okabe, Norihiro Okada, Mikiko Tanaka

    DEVELOPMENTAL BIOLOGY   347 ( 1 )   236 - 245   2010.11

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    The pelvic fin position among teleost fishes has shifted rostrally during evolution, resulting in diversification of both behavior and habitat. We explored the developmental basis for the rostral shift in pelvic fin position in teleost fishes using zebrafish (abdominal pelvic fins) and Nile tilapia (thoracic pelvic fins). Cell fate mapping experiments revealed that changes in the distribution of lateral plate mesodermal cells accompany the trunk-tail protrusion. Presumptive pelvic fin cells are originally located at the body wall adjacent to the anterior limit of hoxc10a expression in the spinal cord, and their position shifts rostrally as the trunk grows. We then showed that the differences in pelvic fin position between zebrafish and Nile tilapia were not due to changes in expression or function of gdf11. We also found that hox-independent motoneurons located above the pelvic fills innervate into the pelvic musculature. Our results suggest that there is a common mechanism among teleosts and tetrapods that controls paired appendage positioning via gdf11, but in teleost fishes the position of prospective pelvic fin cells on the yolk surface shifts as the trunk grows. In addition, teleost motoneurons, which lack lateral motor columns, innervate the pelvic fins in a manner independent of the rostral-caudal patterns of hox expression in the spinal cord. (c) 2010 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.ydbio.2010.07.034

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  • Shaping of the lower jaw bone during growth of Nile tilapia Oreochromis niloticus and a Lake Victoria cichlid Haplochromis chilotes: A geometric morphometric approach Reviewed

    Koji Fujimura, Norihiro Okada

    DEVELOPMENT GROWTH & DIFFERENTIATION   50 ( 8 )   653 - 663   2008.10

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    East African cichlids have evolved feeding apparatus morphologies to adapt to diverse feeding environments. However, little is known about how the morphologies are formed during development. Here, we assessed the shape changes of the lower jaw bone during growth of the Nile tilapia Oreochromis niloticus and a Lake Victoria cichlid Haplochromis chilotes using geometric morphometric methods. 'Early Juvenile to Late Juvenile' and 'Late Juvenile to Adult' transitions of the shape change during growth of both O. niloticus and H. chilotes were detected. The 'Early Juvenile to Late Juvenile' transition of the shape change in H. chilotes occurred slightly earlier than in O. niloticus. We also compared the shape changes during growth of the two cichlids. Principal component analysis showed both commonalities and differences in the morphological changes between the cichlids. Our data suggest that most shape change may have a similar pattern during the growth of O. niloticus and H. chilotes, and that the differences in adult shapes may be due to differences arising early in development, not to the difference of shape change during growth. These data provide a basis for understanding the developmental mechanisms underlying this adaptive trait of East African cichlids.

    DOI: 10.1111/j.1440-169X.2008.01063.x

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  • Bone development in the jaw of Nile tilapia Oreochromis niloticus (Pisces : Cichlidae) Reviewed

    Koji Fujimura, Norihiro Okada

    DEVELOPMENT GROWTH & DIFFERENTIATION   50 ( 5 )   339 - 355   2008.6

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    East African cichlids have evolved feeding apparatus morphologies adapted to their diverse feeding behaviors. The evolution of the oral jaw morphologies is accomplished by the diversity of bone formation during development. To further understand this evolutionary process, we examined the skeletal elements of the jaw and their temporal and sequential emergence, categorized by developmental stages, using the Nile tilapia Oreochromis niloticus as a model cichlid. We found that chondrogenesis started in Stage 17. The deposition of osteoid for the dermal bones commenced in Stage 18. The uptake of calcium dramatically shifted from the surface of larvae to the gills in Stage 20. The bone mineralization of the skeleton began in Stage 25. These data provide important information regarding the sequential events of craniofacial development in East African cichlids and lay the groundwork for studying the molecular mechanisms underlying adaptation of jaw structure to feeding behavior.

    DOI: 10.1111/j.1440-169x.2008.01032.x

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  • Heterotypy in the N-terminal region of growth/differentiation factor 5 (GDF5) mature protein during teleost evolution Reviewed

    Koji Fujimura, Yohey Terai, Naoya Ishiguro, Masaki Miya, Mutsumi Nishida, Norihiro Okada

    MOLECULAR BIOLOGY AND EVOLUTION   25 ( 5 )   797 - 800   2008.5

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    Heterotypy is now recognized as a generative force in the formation of new proteins through modification of existing proteins. We report that heterotypy in the N-terminal region of the mature growth/differentiation factor 5 (GDF5) protein occurred during evolution of teleosts. N-terminal length variation of GDF5 was found among teleost interfamilies and interorders but not within teleost families or among tetrapods. We further show that increase of proline and glutamine to the N-terminal region of mature GDF5 occurred in Eurypterygii, the higher lineage of teleosts. Because the basic amino acids, believed to control diffusion, are conserved in this region across all species examined, we suggest that the N-terminal elongation of the mature GDF5 protein during evolution has altered the protein diffusion in Eurypterygii, leading to high concentrations of the protein in the joint of the pharyngeal skeleton, the location of cartilage formation during development.

    DOI: 10.1093/molbev/msn041

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  • Possible involvement of SINEs in mammalian-specific brain formation Reviewed

    Takeshi Sasaki, Hidenori Nishihara, Mika Hirakawa, Koji Fujimura, Mikiko Tanaka, Nobuhiro Kokubo, Chiharu Kimura-Yoshida, Isao Matsuo, Kenta Sumiyama, Naruya Saitou, Tomomi Shimogori, Norihiro Okada

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   105 ( 11 )   4220 - 4225   2008.3

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    Retroposons, such as short interspersed elements (SINEs) and long interspersed elements (LINES), are the major constituents of higher vertebrate genomes. Although there are many examples of retroposons' acquiring function, none has been implicated in the morphological innovations specific to a certain taxonomic group. We previously characterized a SINE family, AmnSINE1, members of which constitute a part of conserved noncoding elements (CNEs) in mammalian genomes. We proposed that this family acquired genomic functionality or was exapted after retropositioning in a mammalian ancestor. Here we identified 53 new AmnSINE1 loci and refined 124 total loci, two of which were further analyzed. Using a mouse enhancer assay, we demonstrate that one SINE locus, AS071, 178 kbp from the gene FGF8 (fibroblast growth factor 8), is an enhancer that recapitulates FGF8 expression in two regions of the developing forebrain, namely the diencephalon and the hypothalamus. Our gain-of-function analysis revealed that FGF8 expression in the diencephalon controls patterning of thalamic nuclei, which act as a relay center of the neocortex, suggesting a role for FGF8 in mammalian-specific forebrain patterning. Furthermore, we demonstrated that the locus, AS021, 392 kbp from the gene SATB2, controls gene expression in the lateral telencephalon, which is thought to be a signaling center during development. These results suggest important roles for SINEs in the development of the mammalian neuronal network, a part of which was initiated with the exaptation of AmnSINE1 in a common mammalian ancestor.

    DOI: 10.1073/pnas.0709398105

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  • Development of the embryo, larva and early juvenile of Nile tilapia Oreochromis niloticus (Pisces : Cichlidae). Developmental staging system Reviewed

    Koji Fujimura, Norihiro Okada

    DEVELOPMENT GROWTH & DIFFERENTIATION   49 ( 4 )   301 - 324   2007.5

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    We described the developmental stages for the embryonic, larval and early juvenile periods of Nile tilapia Oreochromis niloticus to elucidate sequential events of craniofacial development. Craniofacial development of cichlids, especially differentiation and morphogenesis of the pharyngeal skeleton, progresses until about 30 days postfertilization (dpf). Because there is no comprehensive report describing the sequential processes of craniofacial development up to 30 dpf, we newly defined 32 stages using a numbered staging system. For embryonic development, we defined 18 stages (stages 1-18), which were grouped into seven periods named the zygote, cleavage, blastula, gastrula, segmentation, pharyngula and hatching periods. For larval development, we defined seven stages (stages 19-25), which were grouped into two periods, early larval and late larval. For juvenile development until 30 dpf, we defined seven stages (stages 26-32) in the early juvenile period. This developmental staging system for Nile tilapia O. niloticus will benefit researchers investigating skeletogenesis throughout tilapia ontogeny and will also facilitate comparative evolutionary developmental biology studies of haplochromine cichlids, which comprise the species flocks of Lakes Malawi and Victoria.

    DOI: 10.1111/j.1440-169x.2007.00926.x

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  • magp4 gene may contribute to the diversification of cichlid morphs and their speciation Reviewed

    N Kobayashi, M Watanabe, T Kijimoto, K Fujimura, M Nakazawa, K Ikeo, Y Kohara, T Gojobori, N Okada

    GENE   373   126 - 133   2006.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Lake Victoria harbors more than 300 species of cichlid fish, which are adapted to a variety of ecological niches with various morphological species-specific features. However, it is believed that these species arose explosively within the last 14,000 years and transcripts among Lake Victoria cichlid species are almost identical in sequence. These data prompted us to develop a DNA chip assay to compare patterns of gene expression among cichlid species. We prepared a DNA chip spotted with 6240 elements derived from cichlid expressed sequence tag (EST) clones and successfully characterized gene expression differences between the cichlid species Haplochromis chilotes and Haplochromis sp. "rockkribensis". We identified 14 transcripts that were differentially expressed between these species at an early developmental stage, 15 days post-fertilization (dpf), and several were further analyzed using quantitative real-time PCR (qPCR). One of these differentially expressed transcripts was a homolog of microfibril-associated glycoprotein 4 (magp4), a putative causative gene for the human inherited disease, Smith-Magenis syndrome (SMS), for which facial defects are among the phenotypic features. Further analysis of magp4 expression showed that magp4 was expressed in the jaw portion of cichlid fry and that expression profiles between Haplochromis chilotes and Haplochromis sp. "rockkribensis" differed during development. These data suggest that the differential expression of a gene associated with human cranial morphogenesis may be involved in the diversification of cichlid jaw morphs. (c) 2006 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.gene.2006.01.016

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  • cimp1, a novel astacin family metalloproteinase gene from East African cichlids, is differentially expressed between species during growth Reviewed

    T Kijimoto, M Watanabe, K Fujimura, M Nakazawa, Y Murakami, S Kuratani, Y Kohara, T Gojobori, N Okada

    MOLECULAR BIOLOGY AND EVOLUTION   22 ( 8 )   1649 - 1660   2005.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:OXFORD UNIV PRESS  

    Lake Victoria cichlid fishes are excellent examples of explosive adaptive radiation. Although Lake Victoria cichlids are believed to have arisen during a short period (similar to 14,000 years), they have various species-specific phenotypes. One important phenotype that distinguishes each species is the shape of the jaw, which has diverged to adapt to the wide variety of trophic habitats present in the lake. Here we demonstrate a new approach to investigate the diversification of cichlid jaw morphology at the genetic level by examining differentially expressed genes. We used a DNA chip to compare gene expression levels between closely related cichlid fishes. This analysis indicated that the expression of some genes differed in the larvae of two cichlid species. One such clone encodes anew astacin family metalloproteinase. The expression level of the isolated gene, named cimpl, was analyzed in more detail by real-time quantitative reverse transcription-polymerase chain reaction. A significant difference in cimpl expression was observed between two Haplochromis cichlid species during development. Using in situ hybridization, we found that this gene is expressed only in head and gill epithelia. Biochemical analysis showed that cichlid metalloprotemase l (CiMPl) has proteolytic activity, a common attribute of all astacin family proteins. Because some astacin family proteins contribute to morphogenesis in animals, CiMPl is expected to participate in species-specific head morphogenesis in cichlids. This is the first study to demonstrate that differentially expressed genes among cichlids can be identified using a DNA chip.

    DOI: 10.1093/molbev/msi159

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Books

  • 日本魚類学会編「魚類学の百科事典」

    藤村 衡至( Role: Joint author ,  pp.128-131 「鰓」)

    丸善出版  2018.10 

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MISC

  • 鰾と肺の進化 ー シーラカンスからのメッセージ Invited

    岡部正隆, 藤村衡至

    生物の科学 遺伝   68 ( 3 )   226 - 232   2014.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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  • 多様な形態の形成ーシクリッド発生学の基礎 Invited

    藤村衡至, 岡田典弘

    生物の科学 遺伝   66 ( 2 )   146 - 152   2012.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Presentations

  • ポリプテルス神経胚の外鰓形成誘導領域における遺伝子発現の組織学的解析

    中田樹, 村瀬愛枝, 小田鼓乃佳, 岡部正隆, 藤村衡至

    日本動物学会 第75回関東支部大会  2023.3 

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  • ポリプテルス胚を用いたエレクトロポレーション法の検討

    矢吹悠太朗, 村瀬愛枝, 岡部正隆, 藤村衡至

    日本動物学会 第75回関東支部大会  2023.3 

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  • ゼブラフィッシュの繁殖へ影響を及ぼす新潟の水質とエピジェネティクな要因

    志摩亜弥音, 藤村衡至

    日本動物学会 第75回関東支部大会  2023.3 

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  • ポリプテルスの外鰓形成を誘導する因子の探索

    村瀬愛枝, 小田鼓乃佳, 岡部正隆, 藤村衡至

    日本動物学会第92回大会  2021.9 

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    Presentation type:Poster presentation  

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  • ポリプテルスの外鰓形成を誘導する因子の探索

    村瀬愛枝, 小田鼓乃佳, 岡部正隆, 藤村衡至

    日本進化学会第23回大会  2021.8 

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  • ポリプテルス胚におけるtbx1、pax8遺伝子の発現解析

    村瀬愛枝, 岡部正隆, 藤村衡至

    日本動物学会関東支部第72回大会  2020.3 

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  • 真骨類でのtbx4遺伝子の発現調節機構の進化

    長谷川達也, 伊藤廉, 渡邉和, 藤村衡至

    日本動物学会関東支部第72回大会  2020.3 

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  • 真骨類tbx5a/b遺伝子の比較ゲノム解析

    矢野泰良, 藤村衡至

    日本動物学会関東支部第72回大会  2020.3 

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  • ポリプテルス胚におけるfoxi遺伝子の発現解析

    小田鼓乃佳, 岡部正隆, 藤村衡至

    日本動物学会関東支部第72回大会  2020.3 

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  • 熱帯魚を使った、肺/鰾に関する進化発生学的な研究 Invited

    藤村衡至

    新潟大学 形の科学研究センター シンポジウム  2016.9 

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    Presentation type:Oral presentation (invited, special)  

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  • ナイルティラピアの鰾形成について

    渡邉和, 福寿悠星, 藤村衡至

    第6回Tokyo Vertebrate Morphology Meeting  2016.8 

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  • 熱帯魚を使って、脊椎動物の形態進化を考える Invited

    藤村衡至

    第43回 新潟骨ゼミ  2016.3 

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    Presentation type:Oral presentation (invited, special)  

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  • ポリプテルスを用いた、脊椎動物の呼吸器官の進化発生学 Invited

    藤村衡至, 岡部正隆

    第 3 回 Tokyo Vertebrate Morphology Meeting  2013.8 

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    Presentation type:Oral presentation (invited, special)  

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  • EXPERIMENTAL EMBRYOLOGY IN SENEGAL BICHIR PROVIDES INSIGHTS INTO A POSSIBILITY THAT EXTERNAL GILLS MIGHT CONTRIBUTE TO EVOLUTION OF THE HYOBRANCHIAL SKELETON IN VERTEBRATES

    Koji Fujimura, Masataka Okabe

    10th International Congress of Vertebrate Morphology  2013.7 

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  • Development of External Gills in Senegal Bichir, Polypterus senegalus

    Koji Fujimura, Masataka Okabe

    CDB Symposium 2013  2013.3 

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  • ポリプテルスの外鰓と咽頭骨格の形成の関係性から、脊椎動物の進化における外鰓の役割について考える

    藤村衡至, 岡部正隆

    文部科学省 科学研究費 新学術領域研究 「複合適応形質進化の遺伝子基盤解明」 平成24年度 公開シンポジウム  2012.9 

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  • Development of external gills in Senegal bichir, Polypterus senegalus

    藤村衡至, 岡部正隆

    日本進化学会第14回年会  2012.8 

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  • Development of external gills in Senegal bichir, Polypterus senegalus

    Fujimura K, Okabe M

    Euro Evo Devo 2012  2012.7 

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  • Circular DNA intermediate in the duplication of Nile Tilapia vasa genes

    Fujimura K, Kocher TD

    日本分子生物学会第34回年会  2011.12 

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  • 適応進化した東アフリカ湖産シクリッドの形態 Invited

    藤村衡至, 岡田典弘

    日本進化学会第12回年会  2010.8 

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    Presentation type:Oral presentation (invited, special)  

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  • Transgenic Tilapia Project

    Fujimura K, Kocher TD

    University of Maryland, Evolutionary Genetics Seminar  2009.10 

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    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • The developmental basis for craniofacial morphology of cichlid fishes

    Fujimura K, Okada N

    Society for Developmental Biology, Mid-Atlantic Regional Meeting  2009.5 

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  • The developmental basis for craniofacial morphology of cichlid fishes

    Fujimura K, Okada N

    Society for Integrative and Comparative Biology 2009 annual meeting  2009.1 

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  • シクリッドの進化発生学:適応進化した東アフリカ湖産シクリッドの形態進化を調べるための発生学的基盤 Invited

    藤村衡至, 岡田典弘

    日本進化学会第10回年会  2008.8 

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    Presentation type:Oral presentation (invited, special)  

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  • Heterotypy in the N-terminal region of Growth/Differentiation Factor 5 (GDF5) mature protein during teleost evolution

    Fujimura K, Terai Y, Ishiguro N, Miya M, Nishida M, Okada N

    European society for Evolutionary Developmental biology 2nd meeting  2008.8 

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  • Heterotypy in the N-terminal region of Growth/Differentiation Factor 5 (GDF5) mature protein during teleost evolution

    2008.5 

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  • The developmental basis for craniofacial morphology of cichlid fishes

    Fujimura K, Okada N

    Asia Africa Evolution Meeting (JSPS AA Science Platform Program)  2007.12 

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  • カワスズメ科魚類の頭部形態形成のための発生段階

    藤村衡至, 岡田典弘

    日本発生生物学会第40回年会・日本細胞生物学会第59回年会合同大会  2007.5 

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  • カワスズメ科魚類の頭部形態形成のための発生段階

    藤村衡至, 岡田典弘

    日本動物学会関東支部第59回支部会  2007.3 

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  • カワスズメ科魚類の頭部形態形成のための発生段階

    藤村衡至, 岡田典弘

    日本進化学会第8回年会  2006.8 

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  • The construction of the model for craniofacial development of cichlid fishes

    Fujimura K, Okada N

    European society for Evolutionary Developmental biology 1st meeting  2006.8 

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  • シクリッドの採餌器官の形態の発生・進化 Invited

    岡田典弘, 藤村衡至, 小林直樹, 渡邉正勝

    日本進化学会第8回年会  2006.8 

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    Presentation type:Oral presentation (invited, special)  

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  • Molecular analysis of the diversification of cichlids’ jaw shape

    Fujimura K, Watanabe M, Kijimoto T, Kobayashi N, Okada N

    International Symposium on “Dynamics of Developmental Systems”  2005.11 

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  • シクリッドGDF5遺伝子の進化

    藤村衡至, 寺井洋平, 宮正樹, 西田睦, 岡田典弘

    日本進化学会第5回年会  2003.8 

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  • シクリッド GDF5 遺伝子の進化

    藤村衡至, 岡田典弘

    基礎生物学研究所「形態進化のメカニズム」研究会  2003.8 

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    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • Development and genes expression pattern for the jaw morphogenesis of cichlid fishes

    Fujimura K, Watanabe M, Terai Y, Nakazawa M, Murakami Y, Kuratani S, Kohara Y, Gojobori T, Okada N

    Society of Molecular Biology and Evolution (SMBE) conference  2003.6 

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  • 東アフリカ産カワスズメ科魚類における、顎と歯の形態形成に関与する遺伝子の単離とその進化

    藤村衡至, 渡邉正勝, 寺井洋平, 中澤真澄, 村上安則, 倉谷滋, 小原雄治, 五條堀孝, 岡田典弘

    日本分子生物学会第25回年会  2002.12 

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  • Seach for thegenes for morphogenesis of jaw and teeth in East African cichlid fishes

    Fujimura K, Watanabe M, Terai Y, Nakazawa M, Kuratani S, Kohara Y, Gojobori T, Okada N

    International Conference on Morphogenesis and Pattern Formation in Biological Systems  2002.9 

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  • 東アフリカ産カワスズメ科魚類における、顎と歯の形態形成に関与する遺伝子の単離とその進化

    藤村衡至, 渡邉正勝, 寺井洋平, 倉谷滋, 小原雄治, 五條堀孝, 岡田典弘

    日本進化学会第4回年会  2002.8 

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  • The evolution of morphogenetic genes for jaw and teeth in East African cichlid fishes

    Fujimura K, Terai Y, Watanabe M, Okada N

    Molecular Evolution (Jointly organized by ISME and SMBE)  2002.6 

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  • アフリカ産カワスズメ科魚類の歯と顎の遺伝子の単離とその進化

    藤村衡至, 寺井洋平, 岡田典弘

    日本分子生物学会第24回年会  2001.12 

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  • カワスズメ科魚類の、歯と顎の形態形成に関与する遺伝子の単離とその進化

    藤村衡至, 寺井洋平, 岡田典弘

    日本進化学会第3回年会  2001.10 

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Awards

  • 日本進化学会 第5回年会(福岡) ベストポスター賞

    2003  

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    Country:Japan

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Research Projects

  • 錦鯉学センター セットアップ経費

    2024.1 - 2024.3

    System name:学系長裁量経費

    Awarding organization:新潟大学 自然科学系

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  • 錦鯉の体表模様形成の分子機構の解明

    2023.11 - 2024.3

    System name:国際交流推進基金事業

    Awarding organization:新潟県

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    Authorship:Principal investigator 

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  • 古代魚ポリプテルス脳の組織発生学的解析

    Grant number:R05-1020

    2023.4 - 2024.3

    System name:試験研究費助成

    Awarding organization:内田エネルギー科学振興財団

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    Authorship:Principal investigator 

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  • 熱帯魚の繁殖から明らかにする,新潟水環境の特性

    2022.7 - 2023.3

    System name:試験研究費助成

    Awarding organization:佐々木環境技術振興財団

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    Authorship:Principal investigator 

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  • 熱帯魚の繁殖から見た,新潟水環境の特性

    Grant number:R04-1-022

    2022.6 - 2024.3

    System name:試験研究費助成

    Awarding organization:内田エネルギー科学振興財団

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    Authorship:Principal investigator 

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  • 熱帯魚の繁殖に影響を与える新潟水環境の特性の解明

    2022.4 - 2024.3

    System name:研究助成金

    Awarding organization:ユニオンツール育英奨学会

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    Authorship:Principal investigator 

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  • 形態形成遺伝子の機能を時期・部位特異的にノックダウンする実験系の確立

    2021.4 - 2022.3

    Research category:試験研究費助成

    Awarding organization:内田エネルギー科学振興財団

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    Authorship:Principal investigator 

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  • 古代魚ポリプテルス胚を用いたゲノム編集による遺伝子機能解析

    2020.4 - 2021.3

    System name:試験研究費助成

    Awarding organization:内田エネルギー科学振興財団

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    Authorship:Principal investigator 

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  • 古代魚の幼魚に見られる外鰓の役割を実験的に検証する

    2020.4 - 2021.3

    System name:試験研究費助成

    Awarding organization:佐々木環境技術振興財団

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    Authorship:Principal investigator 

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  • 適応の副産物としての種分化: 環境適応が引き起こす生殖的隔離

    2018.4 - 2021.3

    System name:基盤研究(C)

    Awarding organization:日本学術振興会

    寺井 洋平

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    Grant type:Competitive

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  • 新潟の水道水の特性と熱帯魚の繁殖への影響

    2018.4 - 2019.3

    System name:試験研究費助成

    Awarding organization:内田エネルギー科学振興財団

    藤村 衡至

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    Authorship:Principal investigator  Grant type:Competitive

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  • 真骨類の鰾の進化に関わる機能ゲノム解析

    2017.4 - 2018.3

    System name:試験研究費助成

    Awarding organization:内田エネルギー科学振興財団

    藤村 衡至

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    Authorship:Principal investigator  Grant type:Competitive

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  • 硬骨魚類が水中環境で適応進化させた鰾の比較ゲノム解析

    2017.4 - 2018.3

    System name:試験研究費助成

    Awarding organization:佐々木環境技術振興財団

    藤村 衡至

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    Authorship:Principal investigator  Grant type:Competitive

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  • External gill development in bichirs and the evolution of vertebrate respiratory organ

    2015.4 - 2017.3

    System name:Grant-in-Aid for Young Scientists (B)

    Awarding organization:JSPS

    Koji FUJIMURA

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    Authorship:Principal investigator  Grant type:Competitive

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  • 視覚の適応が創出する種の多様性

    2014.4 - 2017.3

    System name:基盤研究(C)

    Awarding organization:日本学術振興会

    寺井 洋平

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    Grant type:Competitive

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  • ポリプテルスの外鰓形成から解き明かす、脊椎動物の陸上進出に伴った呼吸器官の進化

    2014.4 - 2015.3

    System name:試験研究費助成

    Awarding organization:内田エネルギー科学振興財団

    藤村 衡至

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    Authorship:Principal investigator  Grant type:Competitive

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  • 脊椎動物の陸上進出における、呼吸器官の進化と外鰓の役割

    2011.4 - 2014.3

    System name:特別研究員奨励費 (PD)

    Awarding organization:日本学術振興会

    藤村 衡至

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    Authorship:Principal investigator  Grant type:Competitive

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  • Heterotypy in the N-terminal region of Growth/Differentiation Factor 5 (GDF5) mature protein during teleost evolution

    2008.8

    System name:Travel Award

    Awarding organization:Inoue Foundation for Science

    FUJIMURA Koji

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    Authorship:Principal investigator  Grant type:Competitive

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  • 頭部形態が多様化しているシクリッドの発生分化と遺伝子発現様式の解明

    2004.4 - 2005.3

    System name:特別研究員奨励費 (DC2)

    Awarding organization:日本学術振興会

    藤村 衡至

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    Authorship:Principal investigator  Grant type:Competitive

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Teaching Experience (researchmap)

  • 環境汚染論(新潟大学 専門講義科目)

    2020.10

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  • 生物学-生物多様性A-

    Institution name:新潟大学 教養講義科目

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  • 自然環境科学実験B

    Institution name:新潟大学 専門実験科目

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  • 生物学基礎実習a

    Institution name:新潟大学 専門実験科目

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  • 環境生物学演習

    Institution name:新潟大学 専門演習科目

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  • 課題研究B

    Institution name:新潟大学 専門科目

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  • 自然環境科学総論

    Institution name:新潟大学 専門導入科目

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  • 生物学実験 I

    Institution name:新潟大学 教養実験科目

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  • 自然科学基礎実験

    Institution name:新潟大学 教養実験科目

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  • 専門力アクティブ・ラーニング

    Institution name:新潟大学 専門導入科目

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  • 日本事情自然系A

    Institution name:新潟大学 短期留学生科目

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  • 進化生物学特論Ⅳ

    Institution name:新潟大学大学院修士課程

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  • 多様性生物学特論III

    Institution name:新潟大学大学院博士課程

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  • 進化生物学

    Institution name:新潟大学 専門講義科目

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  • 機能形態学B

    Institution name:新潟大学 専門講義科目

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Teaching Experience

  • 自然環境科学研究演習

    2023
    Institution name:新潟大学

  • 自然環境科学特論C

    2023
    Institution name:新潟大学

  • 理学基礎演習

    2022
    Institution name:新潟大学

  • 理学スタディ・スキルズ

    2022
    Institution name:新潟大学

  • 日本事情自然系A

    2022
    Institution name:新潟大学

  • 自然科学総論V

    2022
    Institution name:新潟大学

  • 多様性生物学特論II

    2021
    Institution name:新潟大学

  • 環境経済システム論I

    2021
    Institution name:新潟大学

  • 安全教育

    2021
    Institution name:新潟大学

  • 課題研究C

    2021
    Institution name:新潟大学

  • 課題研究B

    2021
    Institution name:新潟大学

  • 進化生物学特論I

    2020
    Institution name:新潟大学

  • 課題研究(自然環境)B

    2020
    Institution name:新潟大学

  • 環境汚染論

    2020
    Institution name:新潟大学

  • 多様性生物学C

    2020
    Institution name:新潟大学

  • 自然環境科学実験B2

    2019
    Institution name:新潟大学

  • 自然環境科学実験B1

    2018
    Institution name:新潟大学

  • 自然環境科学総論

    2018
    Institution name:新潟大学

  • 自然科学基礎実験

    2017
    Institution name:新潟大学

  • 生物学基礎実習a

    2017
    Institution name:新潟大学

  • 日本事情自然系A

    2017
    -
    2022
    Institution name:新潟大学

  • 理学スタディ・スキルズ

    2017
    -
    2022
    Institution name:新潟大学

  • 課題研究B

    2017
    -
    2021
    Institution name:新潟大学

  • 課題研究C

    2017
    -
    2021
    Institution name:新潟大学

  • 課題研究A

    2017
    -
    2021
    Institution name:新潟大学

  • 専門力アクティブ・ラーニング

    2017
    -
    2018
    Institution name:新潟大学

  • 安全教育

    2015
    -
    2021
    Institution name:新潟大学

  • 生物学-生物多様性A-

    2015
    Institution name:新潟大学

  • 研究発表演習Ⅰ(中間発表)

    2015
    Institution name:新潟大学

  • 環境科学セミナーⅠ

    2015
    Institution name:新潟大学

  • 進化生物学

    2014
    Institution name:新潟大学

  • 機能形態学B

    2014
    Institution name:新潟大学

  • 課題研究

    2014
    -
    2021
    Institution name:新潟大学

  • 自然環境科学概論B

    2014
    -
    2020
    Institution name:新潟大学

  • 自然環境科学実験B

    2014
    -
    2020
    Institution name:新潟大学

  • 生物学実験 I

    2014
    -
    2020
    Institution name:新潟大学

  • 自然科学実験法

    2014
    -
    2020
    Institution name:新潟大学

  • 環境科学スタディスキルズ

    2014
    -
    2020
    Institution name:新潟大学

  • 進化生物学特論Ⅳ

    2014
    -
    2017
    Institution name:新潟大学

  • 適応生物学

    2014
    -
    2016
    Institution name:新潟大学

  • 環境生物学演習

    2013
    Institution name:新潟大学

  • 生物学-生物多様性A-

    2013
    Institution name:新潟大学

  • 基礎生物学実験

    2013
    -
    2020
    Institution name:新潟大学

  • 多様性生物学特論Ⅲ

    2013
    -
    2020
    Institution name:新潟大学

▶ display all

 

Media Coverage

  • 新潟大学に錦鯉学センター設置 TV or radio program

    NHK  2023.8

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    Author:Other 

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  • 新潟大学に「錦鯉学センター」 模様形成のメカニズム、疾病対策など研究 Newspaper, magazine

    新潟日報  2023.8

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