Updated on 2024/03/28

写真a

 
SAITOH Osamu
 
Organization
Academic Assembly Institute of Medicine and Dentistry Health Sciences Associate Professor
Faculty of Medicine School of Health Sciences Medical Technology Associate Professor
Title
Associate Professor
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Degree

  • 博士(保健学) ( 2017.3   新潟大学 )

  • 修士(保健学) ( 2013.3   新潟大学 )

Research Interests

  • 生理学

  • 不整脈

  • 心臓電気生理

  • カテーテルアブレーション

  • 自律神経

  • 循環生理学

  • 生体医工学

  • 医用超音波

Research Areas

  • Life Science / Cardiology

  • Life Science / Biomedical engineering

Research History (researchmap)

  • Niigata University   Faculty of Medicine School of Health Sciences   Associate Professor

    2024.2

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  • Niigata University   Faculty of Medicine School of Health Sciences   Lecturer

    2020.11 - 2024.1

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  • Niigata University   Faculty of Medicine School of Health Sciences   Assistant Professor

    2014.11 - 2020.10

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  • 新潟県厚生連 新潟医療センター

    2009.10 - 2014.10

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  • 博医会 新潟こばり病院

    2000.10 - 2009.9

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  • 日本外科病理研究所

    1998.4 - 2000.9

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Research History

  • Niigata University   Medical Technology, School of Health Sciences, Faculty of Medicine   Associate Professor

    2024.2

  • Niigata University   Health Sciences, Institute of Medicine and Dentistry, Academic Assembly   Associate Professor

    2024.2

  • Niigata University   Faculty of Medicine School of Health Sciences Medical Technology   Lecturer

    2020.11 - 2024.1

  • Niigata University   Faculty of Medicine School of Health Sciences Medical Technology   Assistant Professor

    2014.11 - 2020.10

Education

  • Niigata University   Graduate School of Health Sciences   博士後期課程

    2013.4 - 2017.3

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  • Niigata University   Graduate School of Health Sciences   博士前期課程

    2010.4 - 2013.3

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  • Niigata University   医療技術短期大学部   衛生技術学科

    1995.4 - 1998.3

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Professional Memberships

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Committee Memberships

  • 新潟県臨床検査技師会   理事  

    2021.5   

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  • 日本臨床衛生検査技師会   臨地実習指導者講習会技術教本 委員  

    2020.9 - 2022.5   

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    Committee type:Academic society

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  • 日本臨床衛生検査技師会   認定心電検査技師制度WG 委員  

    2017.9   

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  • 日本ホルター・ノンインベイシブ心電学研究会   幹事  

    2016.6 - 2021.3   

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  • 新潟県臨床検査技師会   臨床生理部門 委員  

    2005.4   

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Papers

  • Symmetrical recovery time course between impedance and intramyocardial temperature after bipolar radiofrequency ablation; Role of impedance monitoring to estimate temperature rise. Reviewed International journal

    Takumi Kasai, Osamu Saitoh, Kyogo Fuse, Ayaka Oikawa, Hiroshi Furushima, Masaomi Chinushi

    Indian pacing and electrophysiology journal   2023.12

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    INTRODUCTION: During radiofrequency (RF) ablation, impedance monitoring has been used to avoid steam-pop caused by excessive intramyocardial temperature (IMT) rise. However, it is uncertain why the impedance decline is related to steam-pop and whether the impedance decline is correlated to IMT. METHODS: Twenty-one bipolar ablations (40 W, 30-g contact, 120 s) were attempted for seven perfused porcine myocardium. Immediately after ablation, a temperature electrode was inserted into the mid-myocardial portion, and the recovery process of impedance and its correlation to IMT were assessed. RESULTS: Transmural lesion was created in all 21 applications but steam-pop occurred in 5/21 applications with large impedance decline. In the 16 applications without steam-pop, impedance and IMT soon after ablation were 97.2 ± 4.0 Ω and 66.1 ± 4.8 °C, respectively. Reasonably high linear correlation was demonstrated between the maximum IMT after ablation and impedance differences before and after ablation. Recovery processes of the decreased impedance and the elevated IMT fit well to each equation of the single exponential decay function and showed symmetric shapes with no statistical difference of time constant (100.1 ± 34.5 s in impedance vs. 108.7 ± 27.3 s in IMT) and half-time of recovery (144.5 ± 49.8 s in impedance vs. 156.9 ± 39.4 s in IMT). Recovered impedance after ablation (104.8 ± 3.9 Ω) was 5.1 ± 2.0 Ω smaller than that before ablation (109.9 ± 2.7 Ω), suggesting several factors other than IMT rise participate in impedance decline in RF ablation. CONCLUSIONS: Recovery of impedance and IMT after ablation well correlated, which supports the usefulness of impedance monitoring for safe RF ablation.

    DOI: 10.1016/j.ipej.2023.12.001

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  • Distribution of excitation recoverable myocardium after radiofrequency ablation and its relation to energy application time and irrigation Reviewed International journal

    Osamu Saitoh, Takumi Kasai, Kyogo Fuse, Masaomi Chinushi

    Journal of Cardiovascular Electrophysiology   34 ( 4 )   928 - 941   2023.3

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    INTRODUCTION: Radiofrequency (RF) catheter ablation induces excitation recoverable myocardium around durable core lesions, and its distribution may be different depending on energy delivery methods. METHODS AND RESULTS: In coronary perfusing porcine hearts, pacing threshold through the ventricle was measured using eight-pole (1-mm distance) needle electrodes vertically inserted into myocardium before, within 3 min after and 40 min after 40 W ablation with 10-g catheter contact (Group 1: irrigation catheter for 15 s, Group 2: irrigation catheter for 40 s, Group 3: nonirrigation catheter for 15 s, Group 4: nonirrigation catheter for 40 s). Ablation was accomplished in all 12 ablations in Groups 1-3 whereas in 8/12 ablations in Group 4 because of high-temperature rise. Within 3 min after ablation, 10.0 V pacing uncaptured electrodes were distributed from the surface to inside the myocardium, and its depth was deeper in 40 s than in 15 s ablation. 40 min after ablation, excitation recovery at one or more electrodes below the durable lesion was observed in all Groups. Excitation recovery electrodes were also observed on the surface in Group 1 but not the other Groups. Accordingly, the number of excitation-recovered electrodes were larger in Group 1 than the other Groups. CONCLUSIONS: Regardless of the ablation methods, excitation recoverable myocardium was present around 1.0 mm below the durable lesions. Lesions created by short application time using an irrigation catheter may have included large excitation recoverable myocardium soon after ablation because of the presence of reversible myocardium on well-irrigated myocardial surfaces.

    DOI: 10.1111/jce.15873

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  • Incorrect Placement of the Ground Electrode in the 12-lead Electrocardiogram: Its Clinical Implications and a Simple Identification Strategy in Healthcare Fields Reviewed

    Ningen Dock International   10 ( 1 )   92 - 97   2023.3

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  • Impedance‐decline‐guide power control long application time bipolar radiofrequency catheter ablation Reviewed International journal

    Osamu Saitoh, Takumi Kasai, Kyogo Fuse, Ayaka Oikawa, Hiroshi Furushima, Masaomi Chinushi

    Journal of Cardiovascular Electrophysiology   33 ( 12 )   2538 - 2545   2022.9

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    INTRODUCTION: Bipolar (BIP) radiofrequency (RF) ablation creates deep myocardial lesions but ideal energy application modes to treat ventricular arrhythmias originating from deep inside the thick myocardium have not been well established. An experimental study was performed to clarify whether high power and long application time BIP ablation were performable by impedance-decline-guide power control (PC) and whether it could create transmural lesions in the thick ventricle with a minimum risk of steam-pop. METHODS AND RESULTS: Perfused porcine ventricle (18.4 ± 2.3 mm) was placed in an experimental bath and BIP ablation (50 W) for 120 s was attempted with catheter contact of 30-g using two protocols; fixed power (FP) and impedance-decline-guide PC. In the latter protocol, BIP ablation was started from 50 W, while the energy was decreased to 40-20 W according to the impedance decline during RF ablation. FP ablation was attempted in 30 applications and the transmural lesion was created in all 30, although steam-pop occurred in 16/30 applications (53%). Low minimum impedance, large total impedance decline (TID), and %-TID were associated with the steam-pop occurrence. PC ablation was attempted in another 21 applications, and the transmural lesion was created in all 21 without steam-pop. PC ablation was superior to FP ablation (21/21 vs. 14/30, p < .001) in the creation of a transmural lesion without resulting in steam-pop. CONCLUSIONS: High power and long application time BIP ablation seems to be feasible according to the impedance-decline-guide approach, which could create transmural lesions in thick porcine ventricles with minimal risk of steam-pop.

    DOI: 10.1111/jce.15684

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  • Excitation Recovery on the Surface Myocardium After Shorter but Not Nominal Time Radiofrequency Application Using an Open Irrigation Catheter Reviewed

    Masaomi Chinushi, Osamu Saitoh

    Circulation: Arrhythmia and Electrophysiology   15 ( 1 )   e010392   2021.12

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    DOI: 10.1161/CIRCEP.121.010392

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  • Anti‐tachycardia pacing for non‐fast and fast ventricular tachycardias in individual Japanese patients: From Nippon‐storm study Reviewed

    Masaomi Chinushi, Osamu Saitoh, Hiroshi Furushima, Yoshifusa Aizawa, Takashi Noda, Takashi Nitta, Tohru Ohe, Takashi Kurita

    Journal of Arrhythmia   37 ( 4 )   1038 - 1045   2021.8

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    BACKGROUND: Anti-tachycardia pacing (ATP) delivered from an implantable device is a useful tool to terminate ventricular tachycardia (VT). But its real-world efficacy for those patients having multiple VTs with varying VT rates has not been fully studied. METHODS: Using the Nippon-storm study database, efficacy of patient-by-patient basis ATP programing for Japanese patients having both non-fast (120-187 bpm) and fast VT (≥188 bpm) was assessed. According to the useful criteria of ≥50% success termination by ATP, patients were divided into three subgroups; success ≥50% for both non-fast and fast VT (both useful), ≥50% only for non-fast VT (non-fast VT useful), or ≥50% for neither non-fast nor fast VT (neither useful). RESULTS: During a median follow-up of 28 months, ATP terminated 184 of the 203 non-fast VT episodes (91%) and 86 of the 113 fast VT episodes (76%) in all 41 patients. In the patient-by-patient analysis, efficacy of ATP was not different between non-fast and fast VT in most of the patients (36/41 = 88%); 32 patients were in the both useful and four other patients in the neither useful. Neither ischemic nor non-ischemic structural heart disease was associated with the ATP efficacy, whereas LVEF more than 37.0% and non-prescribed amiodarone were characteristics of the patients classified into the both useful. CONCLUSIONS: ATP well terminated both non-fast and fast VT occurring in individual Japanese patients with various structural heart diseases in the real-world device treatment and this finding further supports ATP programing for all device tachycardia detection zones in most patients with multiple VTs.

    DOI: 10.1002/joa3.12572

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  • Impedance decrement indexes for avoiding steam-pop during bipolar radiofrequency ablation: An experimental study using a dual-bath preparation. Reviewed International journal

    Osamu Saitoh, Ayaka Oikawa, Ayari Sugai, Masaomi Chinushi

    Journal of cardiovascular electrophysiology   31 ( 12 )   3302 - 3310   2020.9

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    INTRODUCTION: This experimental study was conducted to explore impedance monitoring for safely performing bipolar (BIP) radiofrequency (RF) ablation targeted to arrhythmia focus. METHODS AND RESULTS: Using a newly designed dual-bath experimental model, contact-force-controlled (20-g) BIP ablation (50 W, 60 s) was attempted for porcine left ventricle (17.0 ± 2.7 mm thickness). BIP ablation was successfully accomplished for 60 s in 75 of the 89 RF applications (84.3%), whereas audible steam-pop occurred in the other 14 RF applications (15.7%). Receiver operating characteristic analysis demonstrated the optimal predictive values regarding the occurrence of steam-pop as follows; thinner myocardial wall (≤14.8 mm), low minimum impedance (≤89 ohm), greater total impedance decrement (TID) (≤ -25 ohm) and %TID (≤ -22.5%). Greater impedance decrement was not observed immediately preceding the occurrence of steam-pop but appeared around 15 s before. Four steam-pops happened before reaching the optimal predictive values of minimum impedance, whereas all 14 steam-pops developed 11.5 ± 9.2 and 8.1 ± 8.1 s after reaching the optimal predictive values of TID and %TID, respectively. Total lesion depth (endocardial plus epicardial) was 10.7 ± 1.2 mm on average, and was well correlated with TID and %TID. Transmural lesion through the myocardial wall was created in 22 RF applications. CONCLUSION: Relatively thinner areas of the myocardium are likely to be at greater risk for steam-pop during BIP RF ablation. Lowering the RF application energy to reduce the impedance decrement may help to lessen this risk.

    DOI: 10.1111/jce.14764

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  • Patient-by-patient basis anti-tachycardia pacing for fast ventricular tachycardia with structural heart diseases. Reviewed International journal

    Masaomi Chinushi, Hiroshi Furushima, Osamu Saitoh, Takashi Noda, Takashi Nitta, Yoshifusa Aizawa, Tohru Ohe, Takashi Kurita

    Pacing and clinical electrophysiology : PACE   43 ( 9 )   983 - 991   2020.6

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    BACKGROUND: Anti-tachycardia pacing (ATP) delivered from an implantable device is an important tool to terminate ventricular tachycardia (VT). But its real-world efficacy for fast VT has not been fully studied. METHODS: Using the database of Nippon-storm study, effect of patient-by-patient basis ATP programming for fast VT (≥188 bpm) was assessed for the patients with structural heart diseases. Fast VTs were divided into three groups depending on heart rate (HR); Group A was 188-209 bpm, and Group-B and Group-C were 210-239 bpm and ≥240 bpm, respectively. RESULTS: During a median follow-up of 28 months, 202 fast VT episodes (209 ± 19 bpm) were demonstrated in the 85 patients. ATP terminated 151 of the 202 episodes (74.8%) in total. The success rate of the ATP was not different among the three groups: 73.3% in Group A, 80.6% in Group B, and 66.7% in Group C. ATP success rate of >50% and >70% was 77.6% and 64.7% of the patients, respectively. Left ventricular ejection fraction (LVEF) was significantly higher in the patients with rather than without successful ATP therapy, and receiver operating characteristic (ROC) analysis revealed that LVEF of 23% was the optimal cut-off value. ATP was less effective in patients taking amiodarone, but etiology of the structural heart diseases, indication of the device implantation, and all Electrocardiogram (ECG) parameters were not useful predictors for successful ATP therapy. CONCLUSIONS: ATP highly terminated fast VT with wide HR ranges in patients with structural heart diseases, and should be considered as the first-line therapy for fast VT except for patients with very low LVEF.

    DOI: 10.1111/pace.13980

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  • Bepridil Inhibits Premature Ventricular Complexes Induced by Cardio-Sympathetic Nerve Stimulation in a Canine Experimental Model. Reviewed

    Osamu Saitoh, Junya Watanabe, Ayari Sugai, Ayaka Oikawa, Mika Sugai, Masaomi Chinushi

    International heart journal   61 ( 2 )   338 - 346   2020.3

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    Sympathetic nerve activity has arrhythmogenic potential for ventricular arrhythmias associated with structural heart diseases. However, a sufficient amount of beta-blockers occasionally cannot be prescribed in some patients.An experimental study was performed to clarify the therapeutic effects of bepridil, a multiple ionic current inhibitor that does not affect beta-adrenergic receptors, for premature beats occurring during enhanced sympathetic nerve activity. Cardio-sympathetic nerve activity was augmented via stellate-ganglion (SG) stimulation in a canine model (n = 8), and the arrhythmogenic potential and anti-arrhythmic effects of bepridil (2 and 4 mg/kg intravenously) were assessed. For safe use, vagal-stimulation-induced slow HR and programmed electrical stimulation were applied to evaluate possible pro-arrhythmic effects of the drug. Heart rate variability (HRV) indexes were used to estimate cardio-autonomic nerve activity.Either side of the SG-stimulation increased BP and HR. Premature beats were induced in 10/16 SG-stimulations and it was more frequent in left (8/8) rather than right stimulation (2/8). Following 2 mg/kg drug administration, premature beats were still inducible in 8/16 stimulations (7/8 in left and 1/8 in right), but burden of the premature beats decreased from 87.1 ± 46.8 to 62.1 ± 42.6 beats. After 4 mg/kg administration, premature beats were inducible in one SG-stimulation. Proarrhythmic effects were not observed in all experiments. Steady-state HRV indexes and percent increases in SG-stimulation-induced BP-elevation and HR-acceleration were similar among the 3 periods (before, 2 and 4 mg/kg of the drug).Bepridil may be an option for ventricular arrhythmias developed during enhanced cardio-sympathetic nerve activity with minimal effect on autonomic nerve responses.

    DOI: 10.1536/ihj.19-494

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  • Enhanced arrhythmogenic potential induced by renal autonomic nerve stimulation: Role of renal artery catheter ablation. Reviewed International journal

    Masaomi Chinushi, Osamu Saitoh, Ayari Sugai, Ayaka Oikawa, Junya Watanabe, Hiroshi Furushima

    Heart rhythm   17 ( 1 )   133 - 141   2020.1

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    BACKGROUND: Renal artery catheter ablation has been reported as a possible therapeutic option for drug-refractory ventricular arrhythmias (VAs) associated with structural heart diseases. OBJECTIVE: To further clarify its therapeutic background, we examined the relationship between electrical nerve stimulation (ENS)-induced blood pressure (BP) elevation and occurrence of VAs by using an acute canine model of renal artery ablation. METHODS: Using a decapolar electrode catheter, ENS was successively applied from the distal, mid, and proximal segments of the renal artery in 8 beagles. The same ENS was repeated after accomplishment of radiofrequency ablation at the ostial site of the renal artery by using an irrigation catheter. RESULTS: Before ablation, ENS increased BP from 140 ± 11/77 ± 11 to 167 ± 20/98 ± 16 mm Hg and heart rate from 100 ± 21 to 131±33 beats/min as well as induced VAs in 20 of the 45 ENS applications. Occurrence of VAs was associated with a greater magnitude of sympathetic nerve augmentation, and VAs were more frequently observed by ENS at the distal (67%) rather than mid/proximal segments of the renal artery (33%). Renal artery ablation was accomplished without any angiographic stenosis, and ENS-induced BP elevation, heart rate acceleration, and VAs occurrence were attenuated not only at the close segment (proximal) but also at the remote segments (mid/distal) of the renal artery. CONCLUSION: The renal autonomic nerves are considered as one of the therapeutic targets for suppression of frequent VAs because its activation has arrhythmogenic potential and induces premature ventricular beats.

    DOI: 10.1016/j.hrthm.2019.07.029

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  • Therapy-Resistant Ventricular Arrhythmias Developed More Often in Advanced Than in Therapeutic Mild Hypothermic Condition. Reviewed

    Osamu Saitoh, Junya Watanabe, Ayaka Oikawa, Ayari Sugai, Hiroshi Furushima, Masaomi Chinushi

    International heart journal   60 ( 5 )   1161 - 1167   2019.9

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    Therapy-resistant ventricular arrhythmias can occur during accidental advanced hypothermic conditions. On the other hand, hypothermic therapy using mild cooling has been successfully accomplished with infrequent ventricular arrhythmia events.To further clarify the therapeutic-resistant arrhythmogenic substrate which develops in hypothermic conditions, an experimental study was performed using a perfusion wedge preparation model of porcine ventricle, and electrophysiological characteristics, inducibility of ventricular arrhythmias, and effects of therapeutic interventions were assessed at 3 target temperatures (37, 32 and 28°C).As the myocardial temperature decreased, myocardial contractions and the number of spontaneous beats deceased. Depolarization (QRS width, stimulus-QRS interval) and repolarization (QT interval, ERP) parameters progressively increased, and dispersion of the ventricular repolarization increased. At 28°C, VF tended to be inducible more frequently (1/11 at 37°C, 1/11 at 32°C, and 5/11 hearts at 28°C), and some VFs at 28°C required greater defibrillation energy to resume basic rhythm.An advanced but not a mild hypothermic condition had an enhanced arrhythmogenic potential in our model. In the advanced hypothermic condition, VF with relatively prolonged F-F intervals and a greater defibrillation energy were occasionally inducible based on the arrhythmogenic substrate characterized as slowed conduction and prolonged repolarization of the ventricle.

    DOI: 10.1536/ihj.18-711

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  • Incorrect Holter-ECG analysis caused by the pacemaker delivering small high-frequency currents for thoracic impedance measurement. Reviewed

    Masaomi Chinushi, Hitoshi Tachikawa, Yuko Chinushi, Toshio Yamaguchi, Osamu Saitoh, Takashi Tsuda

    Journal of cardiology cases   16 ( 6 )   219 - 222   2017.12

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    In an 86-year-old woman who had been treated for sick sinus syndrome, the small high-frequency current delivered by pacemaker in order to measure the minutes ventilation for utilizing the rate-response mode was transiently over-sensed on the Holter electrocardiogram. Although her pacing system was working appropriately, the numbers of the paced beats on the automatic Holter analysis were undercounted (from >60% to <5%) during the over-sensing periods because these currents were recognized as multiple pacing spikes. Physicians need to pay attention to such multiple pacing spike markers, because these can be a cause of unreliable results of the Holter analysis. <Learning objective: Paying attention to multiple pacing spike markers on Holter electrocardiogram is clinically important in patients treated by a rate-response pacemaker. This is because (1) this does not imply the malfunction of the pacemaker system, and (2) results from automatic Holter analysis would not be reliable during the period when these multiple pacing markers were recorded.>.

    DOI: 10.1016/j.jccase.2017.08.007

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  • Bipolar Radiofrequency Catheter Ablation for the Treatment of Arrhythmia Arising from Deep Inside of the Myocardium : Experimental Study for that Efficacy and Safety Reviewed

    Saitoh Osamu

    Niigata medical journal   131 ( 4 )   227 - 241   2017.4

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    Authorship:Lead author   Language:Japanese   Publisher:新潟医学会  

    【目的】深部心筋から生じる不整脈の新しい治療法として期待されるバイポーラー高周波アブレーションの有効性と安全性を実験的に検証する. 【方法】食肉用のブタ心筋切片を用いて実験水槽内で高周波通電を行い (30-40W, 総計122回) , 形成される焼灼傷の大きさ, 貫壁性焼灼の達成度, スチームポップ現象の発生頻度を検討した. 高周波通電モードは, (1) 2本のイリゲーションカテーテルによるバイポーラー通電 (BIP-4) , (2) 2本のイリゲーションカテーテルによるシーケンシャル・ユニポーラー通電 (SEQ) , (3) イリゲーションカテーテルと8mm大型電極ノン・イリゲーションカテーテルによるバイポーラー通電 (BIP-8) を用いた. 【結果】SEQの心筋焼灼深達度は浅く, BIP-4と同等の深部焼灼効果を得ることはできなかった (SEQ vs. BIP-4, 30W : 5.53±1.84 vs. 9.36±2.09mm, P=0.0216, 40W : 6.98±2.01 vs. 10.30±1.78mm, P=0.0362) が, 表面焼灼面積は同等であった. BIP-8での心筋焼灼深達度もBIP-4に至らなかった (30W : 5.98±2.09mm, 40W : 7.54±2.25mm) . 心筋貫壁性焼灼傷の達成はBIP-4で高かったが (30W : 32.4%, 40W : 35.3%) , 同時にスチームポップ現象も高率に観察された (30W : 5.9%, 40W : 14.7%) . SEQでは心筋貫壁性焼灼傷もスチームポップ現象も観察されなかった. 【結論】深部心筋の不整脈起源を焼灼する効果はBIP-4が最も優れており, 2本のイリゲーションカテーテルの必要性が示された. 同時にスチームポップ現象の併発率も高率であったため, 有効・安全にバイポーラー高周波アブレーションを施行するための新たな通電指標の構築が課題にあげられた.

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  • Electrode Contact Force-Controlled Bipolar Radiofrequency Ablation: Different Effects on Lesion Size between Dual- and Single-Bath Preparations. Reviewed International journal

    Masaomi Chinushi, Osamu Saitoh, Junya Watanabe, Ayari Sugai, Katsuya Suzuki, Yukio Hosaka, Hiroshi Furushima

    Pacing and clinical electrophysiology : PACE   40 ( 3 )   223 - 231   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    BACKGROUND: During bipolar (BIP) radiofrequency (RF) ablation using two catheters in humans, each catheter is placed in separate cardiac chambers or spaces. We developed a contact force-controlled experimental preparation, and compared measurements made with two catheters placed in a single bath (SB), versus each catheter placed in separate baths, in order to assess the preparation-dependent differences in the results of BIP-RF ablation. METHODS: In the SB experiments, a porcine heart was placed in the center of the bath, while in the dual-bath (DB) experiments, it was placed between two half baths communicating through windows. RESULTS: The initial impedance was greatest (110.5 ± 7.2 Ω) with the BIP-DB, followed by the BIP-SB (92.0 ± 5.6 Ω) and the unipolar (UNIP) DB (84.9 ± 4.7 Ω) configurations. During 50-W ablation for 60 seconds at a 20-g contact force, the root mean square voltage was 75.7 ± 2.5 V in the BIP-DB, 68.0 ± 2.1 V in the BIP-SB, and 66.8 ± 2.0 V in the UNIP-DB. The mean surface lesion diameters were similar among the three configurations. However, the endocardial lesion depth was 5.60 ± 0.56 mm with the BIP-DB, 4.71 ± 0.64 mm with the BIP-SB, and 4.24 ± 0.58 mm with the UNIP-DB configuration. On average, the endocardial lesions were significantly deeper than the epicardial ones. CONCLUSIONS: BIP ablation created much deeper lesions as compared to UNIP ablation. Lesion depth could be different depending on experimental preparation, and contact force-controlled DB preparation may be a much more appropriate model for studying the effects of BIP ablation.

    DOI: 10.1111/pace.12993

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  • Electrical stimulation-based evaluation for functional modification of renal autonomic nerve activities induced by catheter ablation Reviewed

    Masaomi Chinushi, Katsuya Suzuki, Osamu Saitoh, Hiroshi Furushima, Kenichi Iijima, Daisuke Izumi, Akinori Sato, Mika Sugai, Mitsuya Iwafuchi

    HEART RHYTHM   13 ( 8 )   1707 - 1715   2016.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    BACKGROUND Catheter ablation of the renal artery can be performed without apparent angiographic stenosis. This suggests that renal nerve function can be attenuated with minor structural damage to the renal artery.
    OBJECTIVE To clarify this hypothesis, we examined the relationship between electrical nerve stimulation (ENS)-induced blood pressure (BP) response and severity of histological injury of the renal artery using an acute canine model of renal artery ablation.
    METHODS An irrigation catheter was inserted into the renal arteries of 8 dogs, and radiofrequency current was delivered at 15, 20, or 25 W. ENS was applied to each artery before and after ablation.
    RESULTS Before ablation, ENS increased the BP and heart rate from 145 15/86 13 to 189 21/111 19 mm Hg and from 116 9 to 130 6 beats/min, respectively. Heart rate variability indices and serum catecholamine levels were elevated concomitantly. After ablation, the ENS -induced increase in BP and heart rate were markedly attenuated after 15 W ablation and those were nearly completely inhibited after 20 or 25 W ablation. An increase in heart rate variability indices and serum catecholamine levels became insignificant regardless of the applied energy. Renal artery angiograms revealed stenotic lesions only after 25 W ablation procedures. Histological studies showed mild to moderate injury of the arterial wall and autonomic nerves caused by 20 and 25 W ablation procedures, whereas only minor changes caused by 15 W ablation.
    CONCLUSION Functional renal autonomic nerve ablation is potentially performable with the guidance of ENS.

    DOI: 10.1016/j.hrthm.2016.04.021

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  • Role of left and right side renal sympathetic nerve activity for systemic blood pressure modulation (electrical nerve stimulation and radiofrequency catheter ablation in an experimental model)

    Chinushi Masaomi, Suzuki Katsuya, Saitoh Osamu, Ooya Kana, Iijima Kenichi, Sato Akinori, Izumi Daisuke, Sugai Mika, Furushima Hiroshi

    Shinzo   48 ( 6 )   608 - 616   2016.6

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    腎動脈アブレーションでは両側腎動脈に高周波通電が行われているが, その根拠は明らかにされていない. 高周波通電が両側腎動脈に行われる理由を検証するため動物実験を行った. ビーグル犬を用いて血圧調整における左右腎交感神経興奮の効果を, 腎動脈高周波アブレーション前後の神経電気刺激の昇圧反応から検討した. 腎動脈にイリゲーションカテーテルを挿入して高周波通電を片側腎動脈に行い, 先端電極からの神経電気刺激をアブレーション前後で施行した. アブレーション前の神経電気刺激で昇圧速脈反応が左右腎動脈で同程度に誘発され, 心拍変動解析の交感神経指標と血中カテコラミン値も上昇した. アブレーションを施行した腎動脈では神経電気刺激による昇圧速脈反応は観察されなくなったが, アブレーションをしなかった腎動脈の神経電気刺激では, アブレーション前と同等の昇圧速脈反応が再度誘発された. 腎交感神経刺激による全身交感神経緊張は左右腎動脈で同等に生じ, 一側腎動脈アブレーションは, 対側腎動脈刺激の昇圧速脈誘発に影響を与えなかった. 腎動脈アブレーションで成果を得るには, 両側腎動脈通電が望まれることを支持する所見と思われる.&lt;/p&gt;

    DOI: 10.11281/shinzo.48.608

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  • Autonomic Nerve Activity and Ventricular Tachyarrhythmias Associated with Structural Heart Diseases

    Osamu Saitoh

    Japanese Journal of Electrocardiology   36 ( 1 )   31 - 37   2016

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    交感神経興奮は器質的心疾患症例の心室不整脈に対する催不整脈効果を有し,迷走神経興奮は抗不整脈作用を示すと考えられる.自律神経興奮はその強度のみならず,交感神経興奮と迷走神経興奮のバランス,変動のダイナミクスも不整脈発症に影響を及ぼす.日常診療では,器質的心疾患を有する心室不整脈に,心機能と不整脈の両面からβ遮断薬が用いられるとともに,β遮断薬作用を併せもつIII群抗不整脈薬が処方されている.繰り返し生じる心室頻拍によりelectrical stormに陥った場合,自律神経は重要な治療介入ポイントとなる.初期治療では鎮痛・鎮静・麻酔とともにβ遮断薬が用いられるが,重症例では短期作用型β遮断薬静注,さらには心臓交感神経のブロック・切除,腎動脈カテーテルアブレーション,硬膜外ブロックなどの非薬物治療が用いられる場合があり,交感神経興奮抑制を介した一定の治療効果が期待できる.

    DOI: 10.5105/jse.36.31

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  • Frequency Characteristics and Associations with the Defibrillation Threshold of Ventricular Fibrillation in Patients with Implantable Cardioverter Defibrillators Reviewed

    Kenichi Iijima, Masaomi Chinushi, Osamu Saitoh, Kanae Hasegawa, Keiko Sonoda, Nobue Yagihara, Akinori Sato, Daisuke Izumi, Hiroshi Watanabe, Hiroshi Furushima, Yoshifusa Aizawa, Tohru Minamino

    INTERNAL MEDICINE   54 ( 10 )   1175 - 1182   2015

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    Objective The dominant frequency (DF) in frequency analyses is considered to represent the objective cycle length and complexity of activation under conditions of ventricular fibrillation (VF). However, knowledge regarding the mechanisms determining the DF in human VF is limited. We studied the characteristics of the DF of human VF and relationship between DF and the defibrillation threshold.
    Methods Seventy-two implantable cardioverter-defibrillator patients and 211 VF were studied. Using defibrillation tests, we performed a frequency analysis with fast Fourier transformation. The correlations between DF and clinical characteristics, including the defibrillation threshold, were assessed.
    Results The mean DF of all induced VFs was 5.2 +/- 0.8 Hz. The patients were divided into two groups according to DF: the low-DF (DF &lt;5.2 Hz, n=32) and high-DF (DF &gt;= 5.2 Hz, n=40) groups. The frequency of structural heart disease was significantly higher in the low-DF group. In addition, the QRS duration, QT interval and effective refractory period of the right ventricle (RV-ERP) were significantly longer in the low-DF group. A multivariate analysis showed RV-ERP to be the only independent predictor of DF. Excluding patients receiving group III anti-arrhythmic drugs, which are known to have potent defibrillation threshold effects, the defibrillation threshold was significantly lower in the low-DF group (p=0.026).
    Conclusion We found that the DF of human VF is associated with underlying heart disease, the cardiac function, cardiac conduction, ventricular refractoriness and defibrillation threshold. Our findings may be useful for identifying and managing patients with a high defibrillation threshold.

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  • 心拍変動に伴うQT間隔のダイナミクス トレッドミル運動負荷試験を用いた検討

    鈴木 克弥, 齋藤 修, 阪井 絵理伽, 渡邊 美友貴, 道村 玲香, 阿部 望, 奈良 佳輝, 田中 勇気, 末永 有香, 飯沼 裕美, 神林 真弓, 大井 恵子, 大矢 佳奈, 加藤 公則, 津田 隆志, 池主 雅臣

    新潟県臨床検査技師会誌   54 ( 4 )   212 - 216   2014.10

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    トレッドミル運動負荷試験中のQT間隔の変動がBazett補正式で適正に補正されるか検討した。対象は健常者226名とし、運動によるQT/QTc間隔のダイナミクスを回帰曲線式で分析した。結果、安静臥位から立位への体位変化または運動中の心拍数増加に伴ってBazett補正によるQTc間隔が適正範囲を逸脱した者が23%存在した。

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  • 時系列コンピュータ解析によるJ波高の定量的評価 日内変動における自律神経興奮の関わり

    新潟県臨床検査技師会誌   54 ( 3 )   150 - 154   2014.7

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  • Electrical nerve stimulation during the catheter-based renal nerve denervation

    循環器内科   76 ( 1 )   40 - 43   2014.7

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  • Blood pressure and autonomic responses to electrical stimulation of the renal arterial nerves before and after ablation of the renal artery Reviewed

    Masaomi Chinushi, Daisuke Izumi, Kenichi Iijima, Katsuya Suzuki, Hiroshi Furushima, Osamu Saitoh, Yui Furuta, Yoshifusa Aizawa, Mitsuya Iwafuchi

    Hypertension   61 ( 2 )   450 - 456   2013.2

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    Radiofrequency (RF) catheter ablation of the renal artery is therapeutic in patients with drug-refractory essential hypertension. This study was designed to examine the role of the renal autonomic nerves and of RF application from inside the renal artery in the regulation of blood pressure (BP). An open irrigation catheter was inserted into either the left or right renal artery in 8 dogs. RF current (17±2 watts) was delivered to one renal artery. Electrical autonomic nerve stimulation was applied to each renal artery before and after RF ablation. BP, heart rate, indices of heart rate variability, and serum catecholamines were analyzed. Before RF ablation, electrical autonomic nerve stimulation of either renal artery increased BP from 150±16/ 92±15 to 173±21/105±16 mm Hg. After RF ablation, BP increased similarly when the nonablated renal artery was electrically stimulated, although the rise in BP was attenuated when the ablated renal artery was stimulated. Serum catecholamines and sympathetic nerve indices of heart rate variability increased when electrical autonomic nerve stimulation was applied before RF ablation and to the nonablated renal artery after RF ablation, although it changed minimally when the ablated renal artery was stimulated, suggesting interconnectivity between afferent renal nerve stimulation and systemic sympathetic activity. Renal artery angiogram showed no apparent injury after RF ablation. In conclusion, electrical stimulation of the renal arterial autonomic nerves increases BP via an increase in central sympathetic nervous activity. This response might be used to determine the target ablation site and end point of renal artery RF ablation. © 2012 American Heart Association, Inc.

    DOI: 10.1161/HYPERTENSIONAHA.111.00095

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Books

  • 循環器内科専門医バイブル 第3巻 不整脈 識る・診る・治す

    池主雅臣, 齋藤修, 保坂幸男( Role: Contributor ,  肥大型心筋症における不整脈)

    中山書店  2018.10 

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  • Cardio-Coagulation Vol.1(4) エビデンスにもとづいた抗凝固薬の使い分け

    池主雅臣, 齋藤修, 奥田明子( Role: Contributor ,  慢性腎臓病(CKD)合併心房細動例における坑凝固療法)

    メディカルレビュー社  2014.12 

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  • 不整脈治療 update 第1巻 アブレーション治療戦略の新たな段階

    齋藤修, 池主雅臣( Role: Contributor ,  高血圧に対する腎動脈交感神経アブレーション)

    医薬ジャーナル社  2014.7 

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  • レジデント Vol.7(3) 心電図攻略法

    池主雅臣, 齋藤修( Role: Contributor ,  QRS幅、波高を規定する要因と臨床的意義)

    2014.3 

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  • レジデントノート Vol.15(1) 心電図の読み方トレーニング

    池主雅臣, 齋藤修( Role: Contributor ,  症例問題で腕試し!心電図トレーニング)

    羊土社  2013.4 

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MISC

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Presentations

  • 高周波バイポーラ通電のThermal Latencyによる深部心筋焼灼効果:出力設定と焼灼色調変化の実験的検証

    笠井琢充, 齋藤修, 及川綾花, 古嶋博司, 池主雅臣

    第4回日本不整脈心電学会関東甲信越支部地方会  2024.1 

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    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 深部心筋焼灼に用いるHalf-Normal Saline灌流通電法(HNS)とバイポーラ通電法(BIP)の比較:効果と安全性の実験的検討

    笠井琢充, 齋藤修, 布施亨伍, 竹内天南, 小林紘子, 及川綾花, 古嶋博司, 池主雅臣

    日本不整脈心電学会 カテーテル アブレーション 関連秋季大会2023  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 肥厚心筋焼灼における長時間バイポーラ通電法の安全性と効果:インピーダンスガイド出力調整通電法

    齋藤修, 笠井琢充, 布施亨伍, 竹内天南, 小林紘子, 及川綾花, 古嶋博司, 池主雅臣

    日本不整脈心電学会 カテーテル アブレーション 関連秋季大会2023  2023.11 

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    Event date: 2023.11

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  • 標準12誘導心電図検査の不関電極誤装着を検知する簡便なアルゴリズム構築

    齋藤修, 笠井琢充, 布施亨伍, 竹内天南, 池主雅臣

    第17回日本臨床検査学教育学会学術集会  2023.8 

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  • Irrigation flow volume-dependent distribution of excitation recoverable myocardium after radiofrequency ablation

    Takumi Kasai, Osamu Saitoh, Kyogo Fuse, Amana Takeuchi, Hiroko Kobayashi, Ayaka Oikawa, Hiroshi Furushima, Masaomi Chinushi

    The 69th. Annual Scientific Meeting of the Japanese Circulation Society  2023.7 

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    Event date: 2023.7

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  • Cold saline application through irrigation catheter induces transient inhibition of surface myocardial excitation to depth of several millimeters

    Osamu Saitoh, Takumi Kasai, Kyogo Fuse, Amana Takeuchi, Hiroko Kobayashi, Ayaka Oikawa, Hiroshi Furushima, Masaomi Chinushi

    The 69th. Annual Scientific Meeting of the Japanese Circulation Society  2023.7 

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  • 低出力脂肪除去通電を併用した脂肪下心筋起源不整脈のアブレーション治療

    笠井琢充, 齋藤修, 布施亨伍, 古嶋博司, 池主雅臣

    第87回日本循環器学会学術集会  2023.3 

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    Event date: 2023.3

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  • Mapping by cold saline irrigation; reversible pacing threshold elevation below the catheter contacting myocardium

    Kyogo Fuse, Osamu Saitoh, Takumi Kasai, Hiroshi Furushima, Masaomi Chinushi

    The 87th Annual Scientific Meeting of the Japanese Circulation Society (JCS2023)  2023.3 

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    Event date: 2023.3

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  • Impedance-decline-guide power control bipolar (BIP) radiofrequency (RF) ablation to create transmural lesions in the thick ventricle

    Osamu Saitoh, Takumi Kasai, Kyogo Fuse, Ayaka Oikawa, Hiroshi Furushima, Masaomi Chinushi

    The 87th Annual Scientific Meeting of the Japanese Circulation Society (JCS2023)  2023.3 

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    Event date: 2023.3

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  • 高周波アブレーション治療後の早期不整脈再発:通電モードと可逆的加熱心筋分布の関係

    笠井琢充, 齋藤修, 布施亨伍, 及川綾花, 竹内天南, 池主雅臣

    第3回日本不整脈心電学会 関東甲信越支部地方会  2023.1 

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    Event date: 2023.1

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • バイポーラ通電におけるThermal Latencyの焼灼効果(実験モデルを用いた一次指数関数減衰曲線解析)

    齋藤修, 笠井琢充, 布施亨伍, 安藤明星, 山崎楓花, 及川綾花, 古嶋博司, 池主雅臣

    カテーテルアブレーション関連秋季大会2022  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 脂肪に覆われた心筋から生じる不整脈の高周波アブレーション:脂肪融解先行通電の効果

    笠井琢充, 齋藤修, 布施亨伍, 竹内天南, 真貝珠奈, 及川綾花, 古嶋博司, 池主雅臣

    カテーテルアブレーション関連秋季大会2022  2022.11 

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  • バイポーラアブレーション安全施行の共通指標(異なる通電モードでの比較)

    布施亨伍, 齋藤修, 笠井琢充, 油谷萌香, 小口梨沙, 及川綾花, 古島博司, 池主雅臣

    カテーテルアブレーション関連秋季大会2022  2022.11 

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  • Application Mode Related Myocardial Excitation Recovery After Successful Radiofrequency (RF) Catheter Ablation

    Kyogo Fuse, Osamu Saitoh, Takumi Kasai, Hiroshi Furushima, Masaomi Chinushi

    The 68th Annual Meeting of The Japanese Heart Rhythm Society  2022.6 

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  • Safety and efficacy of impedance decline guide power control bipolar radiofrequency catheter ablation

    Osamu Saitoh, Kyogo Fuse, Takumi Kasai, Hiroshi Furushima, Masaomi Chinushi

    The 68th Annual Meeting of The Japanese Heart Rhythm Society  2022.6 

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  • 心筋深部焼灼のためのバイポーラ高周波通電法(通電時間とカテーテルコンタクトの効果)

    布施亨伍, 笠井琢充, 齋藤修, 橋本海弥, 上村準人, 林尋, 横山悠里, 畠山杏子, 佐藤佳歩, 古嶋博司, 池主雅臣

    第86回日本循環器学会学術集会  2022.3 

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    Event date: 2022.3

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  • Difference in the Myocardial Excitation Recovery between Shorter and Nominal Time Radiofrequency (RF) Application

    Masaomi Chinushi, Osamu Saitoh, Kyogo Fuse, Takumi Kasai, Hiroshi Furushima

    The 86th. Annual Scientific Meeting of the Japanese Circulation Society  2022.3 

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  • Impedance Decrement Represents Intramyocardial Temperature (IT) rather than Myocardial Degeneration in Bipolar Radiofrequency (RF) Ablation

    Osamu Saitoh, Takumi Kasai, Kyogo Fuse, Hiroshi Furushima, Masaomi Chinushi

    The 86th. Annual Scientific Meeting of the Japanese Circulation Society  2022.3 

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  • 心電図四肢不関電極の装着間違いをクイックチェックする判読法

    笠井琢充, 布施亨伍, 齋藤修, 上村準人, 佐藤佳歩, 橋本海弥, 畠山杏子, 林尋, 横山悠里, 古嶋博司, 池主雅臣

    第86回日本循環器学会学術集会  2022.3 

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  • インピーダンスモニタリングから推定する至適心筋焼灼温度 (低温/過剰加熱にならないバイポーラ高周波通電)

    笠井琢充, 齋藤修, 布施亨伍, 橋本海弥, 上村準人, 林尋, 横山悠里, 畠山杏子, 佐藤佳歩, 池主雅臣

    第2回日本不整脈心電学会 関東甲信越支部地方会  2022.1 

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  • バイポーラ高周波通電における インピーダンスモニタリング -心筋内温度とスチームポップ回避-

    齋藤修, 笠井琢充, 布施亨伍, 及川綾花, 池主雅臣

    日本不整脈心電学会 アブレーション関連 秋季大会2021  2021.9 

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    Event date: 2021.9

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  • Intra-cardiac echocardiogram- guided radiofrequency catheter ablation for more safe and effective outcomes: Observations from an experimental study

    Annual meeting of the Japanease Heart Rhythm Society 2021  2021.8 

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    Event date: 2021.7 - 2021.8

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  • Steam-pop-induced surface or extensive myocardial disruption during bipolar radiofrequency catheter ablation

    Osamu Saitoh, Ayaka Oikawa, Ayari Sugai, Masaomi Chinushi

    The 85th Annual Scientific Meeting of the Japanese Circulation Society  2021.3 

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  • Impedance monitoring for predicting steam-pop: an experimental study of bipolar (BIP) radiofrequency (RF) ablation using a dual-bath preparation

    Osamu Saitoh, Ayaka Oikawa, Ayari Sugai, Masaomi Chinushi

    The 85th Annual Scientific Meeting of the Japanese Circulation Society  2021.3 

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  • Therapeutic Effects of Bepridil and Verapamil for Premature Ventricular Complexes Induced During the Enhancement of Cardio-sympathetic Nerve Activity

    Osamu Saitoh, Ayaka Oikawa, Ayari Sugai, Junya Watanabe, Hiroshi Furushima, Masaomi Chinushi

    The 84th. Annual Scientific Meeting of the Japanese Circulation Society  2020.8 

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    Event date: 2020.7 - 2020.8

    Language:English   Presentation type:Oral presentation (general)  

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  • 臨床治療を模倣した高周波 アブレーション (実験系による焼灼効果相違の検証)

    及川綾花, 齋藤修, 楠大輔, 沢辺美弥, 鈴木莉子, 髙木姫奈, 椿真弥, 菅井綾里, 古嶋博司, 池主雅臣

    The 84th. Annual Scientific Meeting of the Japanese Circulation Society  2020.8 

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    Event date: 2020.7 - 2020.8

    Language:Japanese   Presentation type:Poster presentation  

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  • Lesion Characteristics Created by Short- and Nominal-time of RF Application: Requirement of Appropriate Application Time for Stable Lesions

    Osamu Saitoh, Ayaka Oikawa, Ayari Sugai, Akiko Sanada, Shinsuke Okada, Hirotaka Sugiura, Hiroshi Furushima, Masaomi Chinushi

    The 84th. Annual Scientific Meeting of the Japanese Circulation Society  2020.7 

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    Event date: 2020.7 - 2020.8

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  • Reduction of the unexcitable myocardium depth and recovery of surface excitability after shorter radiofrequency (RF) application in an experimental model of porcine myocardium

    2020.5 

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    Event date: 2020.5

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  • 心電図検査のための医用工学・情報科学

    齋藤修

    日本臨床衛生検査技師会 令和5年度認定心電検査技師制度 育成研修会  2023.8 

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  • 心臓電気生理学を整理する:心電図波形の成り立ちと頻脈性不整脈の発生機序

    齋藤 修

    日本臨床衛生検査技師会 令和4年度認定心電検査技師制度 行列のできるスキルアップ研修会  2022.6 

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  • Balanced and unbalanced augmentation of sympathetic nerve activity and its correlation to specific ECG features in cardiovascular diseases

    Ayari Sugai, Osamu Saitoh, Ayaka Oikawa, Junya Watanabe, Hiroshi Furushima, Masaomi Chinushi

    The 12th. Asia Pacific Heart Rhythm Society Scientific Session (APHRS 2019)  2019.10 

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  • バランス・アンバランス型交感神経緊張負荷に伴う心電図変化と心室不整脈

    菅井綾里, 齋藤修, 及川綾花, 渡辺順也, 鈴木克弥, 池主雅臣

    第39回 日本ホルター・ノンインベイシブ心電学研究会  2019.6 

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  • 高周波カテーテルアブレーション(短時間通電による焼灼傷の特徴)

    齋藤修, 及川綾花, 菅井綾里, 古嶋博司, 池主雅臣

    第39回 日本ホルター・ノンインベイシブ心電学研究会  2019.6 

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  • Characteristics of the Lesions Created by Short-duration RF Application: Moderate-lesion on the Endocardial Surface and Dense-lesion Just below

    Osamu Saitoh, Ayaka Oikawa, Ayari Sugai, Hirotaka Sugiura, Akiko Sanada, Shinsuke Okada, Hiroshi Furushima, Masaomi Chinushi

    The 83rd. Annual Scientific Meeting of the Japanese Circulation Society  2019.3 

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  • 急速な高カリウム血症補正が心筋興奮性と心電図指標に与える効果(実験モデルを用いた検証)

    及川綾花, 齋藤修, 菅井綾里, 古嶋博司, 池主雅臣

    The 83rd. Annual Scientific Meeting of the Japanese Circulation Society  2019.3 

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  • 交感神経興奮による心電図変化と心室不整脈(実験モデルでの検討)

    齋藤修, 及川綾花, 菅井綾里, 渡辺順也, 鈴木克弥, 古嶋博司, 池主雅臣

    The 83rd. Annual Scientific Meeting of the Japanese Circulation Society  2019.3 

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  • Underlying Heart Diseases and Patients’ Characteristics Related Circadian Variation of Ventricular Arrhythmias’ Onset: Sub-analysis from NIPPON-storm Study

    Hiroshi Furushima, Masaomi Chinushi, Osamu Saitoh, Takashi Noda, Takashi Nitta, Yoshifusa Aizawa, Tohru Ohe, Takashi Kurita

    The 83rd. Annual Scientific Meeting of the Japanese Circulation Society  2019.3 

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  • Efficacy of Anti-tachycardia Pacing for Very Fast Ventricular Arrhythmias from Sub-analysis of NIPPON-storm Study

    Masaomi Chinushi, Hiroshi Furushima, Osamu Saitoh, Takashi Noda, Takashi Nitta, Yoshifusa Aizawa, Tohru Ohe, Takashi Kurita

    The 83rd. Annual Scientific Meeting of the Japanese Circulation Society  2019.3 

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  • Proximal renal artery catheter ablation for the treatment of ventricular arrhythmia associated with enhanced sympathetic nerve activity International conference

    Osamu Saitoh, Ayari Sugai, Junya Watanabe, Ayaka Oikawa, Hiroshi Furushima, Masaomi Chinushi

    The 11th. Asia Pacific Heart Rhythm Society Scientific Session  2018.10 

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    Venue:Taipei, Taiwan  

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  • Ventricular arrhythmias developed in association with enhanced cardio-sympathetic activity; therapeutic results of Bepridil and its effects on autonomic nerve activity International conference

    Ayari Sugai, Osamu Saitoh, Junya Watanabe, Ayaka Oikawa, Hiroshi Furushima, Masaomi Chinushi

    The 11th. Asia Pacific Heart Rhythm Society Scientific Session  2018.10 

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    Venue:Taipei, Taiwan  

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  • 不整脈診断のための生理機能検査を学ぶ

    齋藤 修

    平成30年度日臨技認定心電検査技師育成研修会  2018.9 

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  • Cooling temperature-dependent changes in the inducibility and therapeutic responses for ventricular arrhythmias in porcine myocardium

    Ayari Sugai, Osamu Saitoh, Junya Watanabe, Ayaka Oikawa, Hiroshi Furushima, Masaomi Chinushi

    第65回日本不整脈心電学会学術大会  2018.7 

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    Venue:東京  

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  • Cooling Temperature dependent Change in Myocardial Conduction and Repolarization; Biphasic Effects on Ventricular Arrhythmias

    Junya Watanabe, Osamu Saitoh, Ayari Sugai, Hiroshi Furushima, Masaomi Chinushi

    The 82nd. Annual Scientific Meeting of the Japanese Circulation Society  2018.3 

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    Venue:大阪  

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  • Renal Sympathetic Nerve as a Therapeutic Target for Ventricular Arrhythmia; Electrical Nerve Stimulation and Radiofrequency Ablation in an Experimental Model

    Masaomi Chinushi, Osamu Saitoh, Junya Watanabe, Ayari Sugai, Hiroshi Furushima

    The 82nd. Annual Scientific Meeting of the Japanese Circulation Society  2018.3 

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    Venue:大阪  

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  • Electrophysiological Characteristics of the Therapy-resistant Ventricular Arrhythmias (VA) :Developed in Hypothermic Condition

    Osamu Saitoh, Junya Watanabe, Ayari Sugai, Hiroshi Furushima, Masaomi Chinushi

    The 82nd. Annual Scientific Meeting of the Japanese Circulation Society  2018.3 

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    Venue:大阪  

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  • 基礎電気生理から心電図を学ぶ

    齋藤 修

    平成29年度日臨技認定心電検査技師育成研修会  2017.10 

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  • Dose-dependent effects of Bepridil for the treatment of ventricular arrhythmias associated with enhanced cardio-sympathetic activity

    Junya Watanabe, Osamu Saitoh, Ayari Sugai, Masaomi Chinushi

    The 10th. Asia Pacific Heart Rhythm Society Scientific Session  2017.9 

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    Venue:横浜  

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  • Electrical nerve stimulation (ENS) guided renal autonomic nerve ablation (Comparison of ENS-induced responses between at the onsite and remote distal sites of ablation)

    Osamu Saitoh, Junya Watanabe, Ayari Sugai, Mika Sugai, Mitsuya Iwafuchi, Masaomi Chinushi

    The 10th. Asia Pacific Heart Rhythm Society Scientific Session  2017.9 

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    Venue:横浜  

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  • 低体温時に誘発される不整脈の電気生理学的特徴 (低体温療法と不整脈源性)

    渡辺順也, 齋藤修, 菅井綾里, 藤原直士, 古嶋博司, 池主雅臣

    第37回 日本ホルター・ノンインベイシブ心電学研究会  2017.6 

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    Venue:東京  

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  • Arrhythmogenesis in enhanced renal autonomic nerve activity and therapeutic option of the proximal renal artery ablation for life-threatening ventricular arrhythmias

    Masaomi Chinushi, Osamu Saitoh, Junya Watanabe, Ayari Sugai, Mika Sugai, Mitsuya Iwafuchi, Katsuya Suzuki, Kenichi, Iijima, Akinori Sato, Daisuke Izumi, Hiorshi Furushima

    The 81st Annual Scientific Meeting of the Japanese Circulation Society  2017.3 

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    Venue:金沢  

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  • Bepridil has a therapeutic effect for cardio-sympathetic activity-induced ventricular arrhythmia without affecting the baseline autonomic balance while preserving the hemodynamic responses by sympathetic stimulation.

    Masaomi Chinushi, Osamu Saitoh, Junya Watanabe, Ayari Sugai, Katsuya Suzuki, Kenichi, Iijima, Akinori Sato, Daisuke Izumi, Hiorshi Furushima

    The 81st Annual Scientific Meeting of the Japanese Circulation Society  2017.3 

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    Venue:金沢  

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  • 低温負荷による不整脈基盤の誘導(低体温療法模倣モデルを用いた検討)

    渡辺順也, 齋藤修, 菅井綾里, 鈴木克弥, 藤原直士, 古嶋博司, 池主雅臣

    第81回 日本循環器学会学術集会  2017.3 

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    Venue:金沢  

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  • Bipolar ablation using longer delivering time vs. higher energy: Gentle impedance decrement better for avoiding complications while obtaining similar lesion

    Osamu Saitoh, Junya Watanabe, Ayari Sugai, Katsuya Suzuki, Yukio Hosaka, Hiroshi Furushima, Masaomi Chinushi

    第81回 日本循環器学会学術集会  2017.3 

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    Venue:金沢  

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  • Establishment of additional electrical parameters for safely and effectively performing bipolar radiofrequency ablation. Observations from an experimental study. International conference

    Osamu Saitoh, Junya Watanabe, Ayari Sugai, Katsuya Suzuki, Minoru Tagawa, Hiroshi Furushima, Masaomi Chinushi

    The 9th. Asia Pacific Heart Rhythm Society Scientific Session  2016.10 

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    Venue:Seoul, Korea  

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  • 教育カンファレンス 心電図判読(基礎〜応用) 参加型症例検討会

    齋藤 修

    第5回北日本支部医学検査学会  2016.10 

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    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • Cervical Sympathetic Nerve (CSN) and Renal Autonomic Nerve (RAN) interventions and supplemental effects of Bepridil for the treatment of ventricular arrhythmias.

    Masaomi Chinushi, Osamu Saitoh, Katsuya Suzuki, Ayari Sugai, Junya Watanabe, Kenichi Iijima, Akinori Sato, Daisuke Izumi, Hiroshi Furushima

    第63回 日本不整脈心電学会学術大会  2016.7 

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    Venue:札幌  

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  • Different depth effects of bipolar catheter ablation between the endocardial and epicardial myocardium. Experimental study using contact-force controlled single and dual bath arrangements.

    Osamu Saitoh, Katsuya Suzuki, Kana Oya, Ayari Sugai, Junya Watanabe, Akiko Okuda, Hiroshi Furushima, Masaomi Chinushi

    第63回 日本不整脈心電学会学術大会  2016.7 

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    Venue:札幌  

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  • Bipolar高周波アブレーション治療を安全効果的に行う電気指標の構築

    齋藤修, 渡辺順也, 菅井綾里, 鈴木克弥, 古嶋博司, 池主雅臣

    第36回 日本ホルター・ノンインベイシブ心電学研究会  2016.6 

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    Venue:大宮  

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  • 体位変換と運動負荷時の心拍血圧変動と血管コンプライアンス

    渡辺順也, 鈴木克弥, 齋藤修, 菅井綾里, 末永有香, 神林真弓, 飯沼裕美, 大井恵子, 池主裕子, 太刀川仁, 山口利夫, 津田隆志, 池主雅臣

    第36回 日本ホルター・ノンインベイシブ心電学研究会  2016.6 

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    Venue:大宮  

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  • 高周波カテーテルアブレーション治療のスチームポップ発症に関係する因子

    齋藤修, 渡辺順也, 戸内悠喬, 長井菜々子, 近藤佑紀, 千葉睦実, 鈴木克弥, 大矢佳奈, 古嶋博司, 池主雅臣

    第80回日本循環器学会学術集会  2016.3 

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    Venue:仙台  

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  • Force control bipolar radiofrequency (bi-RF) catheter ablation under monitoring the dv/dt impedance decrement. Results from the experiments using a new dual-bath model.

    Masaomi Chinushi, Osamu Saitoh, Katsuya Suzuki, Asami Kashiwa, Yukio Hosaka, Hiroshi Furushima

    第80回日本循環器学会学術集会  2016.3 

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    Venue:仙台  

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  • 体位変換と運動中の血圧変化からみた交感神経緊張時の血管反応(トレッドミル運動負荷試験での検討)

    鈴木克弥, 齋藤修, 末永有香, 神林真弓, 飯沼裕美, 大井恵子, 池主裕子, 太刀川仁, 山口利夫, 津田隆志, 池主雅臣

    第80回日本循環器学会学術集会  2016.3 

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    Venue:仙台  

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  • Functional Modification of Renal Autonomic Nerve Activity; Correlation between Electrical Stimulation-induced BP Augmentation and Structural Damage to the Renal Artery.

    Masaomi Chinushi, Katusya Suzuki, Osamu Saitoh, Hiroshi furushima, Kenichi Iijima, Daisuke Izumi, Akinori Satoh, Mitsuya Iwafuchi

    第80回日本循環器学会学術集会  2016.3 

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    Venue:仙台  

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  • Bipolar高周波アブレーションの焼灼効果と安全通電のための指標

    齋藤修, 戸内悠喬, 長井菜々子, 渡辺順也, 近藤佑紀, 千葉睦実, 鈴木克弥, 大矢佳奈, 古嶋博司, 池主雅臣

    第27回日本不整脈学会アブレーション関連秋季大会  2015.10 

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    Venue:郡山  

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  • 立位負荷に伴う自律神経興奮調整と心拍血圧変動 -スペクトラム解析を用いての検討-

    渡辺順也, 齋藤修, 長井菜々子, 近藤佑紀, 戸内悠喬, 千葉睦実, 鈴木克弥, 池主雅臣

    第90回新潟県医学検査学会  2015.10 

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    Venue:新潟  

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  • Role of impedance monitoring during Bipolar (Bi) radiofrequency ablation (RF). -Observations from the experimental study-

    Osamu Saitoh, Katsuya Suzuki, Kana Oya, Asami Kashiwa, Yukio Hosaka, Hiroshi Furushima, Masaomi Chinushi

    第30回日本不整脈学会学術大会、第32回日本心電図学会学術集会  2015.7 

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    Venue:京都  

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  • 自動解析診断が不得手とする不整脈心電図(目視診断で注意するポイント)

    大矢佳奈, 齋藤修, 内山博子, 鈴木克弥, 古嶋博司, 池主雅臣

    第35回日本ホルター・ノンインベイシブ心電学研究会  2015.6 

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    Venue:東京  

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  • 連続Wavelet変換法を用いたQT延長症候群心室細動の周波数特性(誘発心室細動を用いた除細動試験の意義)

    齋藤修, 鈴木克弥, 大矢佳奈, 飯嶋賢一, 和泉大輔, 古嶋博司, 池主雅臣

    第35回日本ホルター・ノンインベイシブ心電学研究会  2015.6 

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    Venue:名古屋  

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  • Bipolar Catheter Ablation Using Dual-bath Experimental Model Creates Larger Lesions, More Clinically-relevant than Estimated by Standard Single-bath Experimental Model

    Masaomi Chinushi, Osamu Saitoh, Katsuya Suzuki, Kana Ooya, Yukio Hosaka, Asami Kashiwa, Hiroshi Furushima, Maki Hoshi, Mitsuya Iwafuchi

    第79回日本循環器学会学術集会  2015.4 

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    Venue:大阪  

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  • 高周波アブレーションにおけるインピーダンスおよび温度モニタリングの重要性

    齋藤修, 鈴木克弥, 大矢佳奈, 阿部望, 道村玲香, 奈良佳輝, 田中勇気, 柏麻美, 保坂幸男, 池主雅臣

    第79回日本循環器学会学術集会  2015.4 

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    Venue:東京  

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  • 薬剤による鎮静/催眠が 心室再分極と自律神経興奮に与える影響

    齋藤修, 杉浦広隆, 岡田慎輔, 樋口浩太郎, 大塚英明, 渡邉真奈美, 鈴木克弥, 大矢佳奈, 池主雅臣

    第79回日本循環器学会学術集会  2015.4 

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    Venue:大阪  

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  • Catheter-based renal nerve ablation: Interaction between left and right side activity estimated by electrical nerve stimulation (ENS) and RF ablation

    Masaomi Chinushi, Katsuya Suzuki, Osamu Saitoh, Kana Ooya, Kenichi Iijima, Akinori Satoh, Daisuke Izumi, Hiroshi Furushima

    第79回日本循環器学会学術集会  2015.4 

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    Venue:大阪  

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  • 通常型房室結節回帰頻拍とATP感受性Koch三角内マイクロリエントリー性頻拍を合併した1例

    杉浦広隆, 岡田慎輔, 樋口浩太郎, 大塚英明, 齋藤修, 池主雅臣

    第26回日本不整脈学会カテーテルアブレーション関連秋季大会  2014.10 

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    Venue:新潟  

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  • Bipolar高周波通電の焼灼効果と安全性 -Dual bathモデルとSingle bathモデルを用いた検討-

    池主雅臣, 阿部望, 道村玲香, 奈良佳輝, 田中勇気, 齋藤修, 鈴木克弥, 柏麻美, 保坂幸男

    第26回日本不整脈学会カテーテルアブレーション関連秋季大会  2014.10 

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    Venue:新潟  

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  • 心拍変動に伴うQT間隔変動のダイナミクス

    鈴木克弥, 齋藤修, 大矢佳奈, 飯沼裕美, 神林真弓, 大井恵子, 津田隆志, 加藤公則, 池主雅臣

    第34回日本ホルター・ノンインベイシブ心電学研究会  2014.6 

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    Venue:名古屋  

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  • 貫壁性心室筋電位からみた心室細動の電気生理学的特徴 ―連続Wavelet変換法を用いた検討―

    齋藤修, 鈴木克弥, 大矢佳奈, 杉浦広隆, 池主雅臣

    第34回日本ホルター・ノンインベイシブ心電学研究会  2014.6 

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    Venue:名古屋  

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  • 体位変換と運動負荷に伴うQT間隔変動とBazett・Fredericia補正

    鈴木克弥, 齋藤修, 大矢佳奈, 阪井絵里伽, 渡邊美友貴, 大井恵子, 神林真弓, 飯沼裕美, 津田隆志, 加藤公則, 池主雅臣

    第78回日本循環器学会学術集会  2014.3 

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    Venue:東京  

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  • トレッドミル運動負荷試験からみた健常例J波の動向

    齋藤修, 鈴木克弥, 大矢佳奈, 阪井絵里伽, 渡邊美友貴, 田川実, 中村裕一, 津田隆志, 加藤公則, 池主雅臣

    第78回日本循環器学会学術集会  2014.3 

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    Venue:東京  

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  • Catheter-based Renal Autonomic Nerve Ablation: Implication of Discrepant Results between Electrical Nerve Stimulation (ENS) Induced Hemodynamic Response and Histological Examinations

    Masaomi Chinushi, Katsuya Suzuki, Osamu Saitoh, Kenichi Iijima, Daisuke Izumi, Hiroshi Furushima, Akinori Sato, Mitsuya Iwafuchi

    第78回日本循環器学会学術集会  2014.3 

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    Venue:東京  

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  • Bipolar (Bi) and Sequential Unipolar (SeqU) Radiofrequency (RF) Ablation for the Treatment of Tachyarrhythmias Originating from Deep Intramyocardial Origin

    Masaomi Chinushi, Yukio Hosaka, Osamu Saitou, Katsuya Suzuki, Toshiaki Yano, Mitsuya Iwafuch

    第78回日本循環器学会学術集会  2014.3 

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    Venue:東京  

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  • 連続Wavelet周波数解析法を用いた心室細動の電気生理学的特徴の検討 -自然停止VFと持続VFの比較-

    齋藤修, 鈴木克弥, 阪井絵里伽, 渡邊美友貴, 大矢佳奈, 飯島賢一, 和泉大輔, 加藤公則, 池主雅臣

    第78回日本循環器学会学術集会  2014.3 

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    Venue:東京  

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  • レートレスポンス機能のための微小電流過剰感知が原因で、ホルター心電図の自動解析結果が不正確となった1例

    池主雅臣, 太刀川仁, 寒河江大介, 佐藤則明, 鈴木克弥, 齋藤修, 大矢佳奈, 神林真弓, 大井恵子, 池主裕子, 山口利夫, 津田隆志

    第6回日本不整脈学会植込みデバイス関連冬季大会  2014.2 

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    Venue:広島  

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  • 神経電気刺激と高周波通電による腎動脈自律神経興奮への介入

    池主雅臣, 鈴木克弥, 齋藤修, 飯嶋賢一, 和泉大輔, 佐藤光希, 古嶋博司, 南野徹, 岩渕三哉

    第30回日本心電学会学術集会  2013.10 

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    Venue:青森  

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  • J波の日内変動から観る自律神経興奮の不整脈源性

    齋藤修, 池主雅臣, 鈴木克弥, 大矢佳奈, 杉浦広隆, 阿部暁, 樋口浩太郎, 大塚英明

    第33回日本ホルター・ノンインベイシブ心電学研究会  2013.6 

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    Venue:東京  

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  • J波出現様式に対する自律神経興奮と心室再分極の関与:ホルター心電図を用いた検討

    齋藤修, 池主雅臣, 鈴木克弥, 杉浦広隆, 阿部暁, 樋口浩太郎, 大塚英明

    第77回日本循環器学会学術集会  2013.3 

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    Venue:横浜  

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  • T Peak-to-End interval (Tp-e) on the Surface Precordial ECG Leads Represents a Distribution of the Intracardiac Spatial LV Repolarization

    Daisuke Izumi, Masaomi Chinushi, Kenichi Iijima, Katsuya Suzuki, Osamu Saito, Akinori Satoh, Hiroshi Furushima, Tohru Minamino

    第77回日本循環器学会学術集会  2013.3 

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    Venue:横浜  

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  • Site-specific Differences in the Renal Nerve Stimulation-induced Blood Pressure Response and Histological Effects of Radiofrequency Renal Artery Ablation

    Masaomi Chinushi, Daisuke Izumi, Kenichi Iijima, Katsuya Suzuki, Osamu Saito, Haruna Honma, Akinori Satoh, Hiroshi Furushima, Mitsuya Iwafuchi

    第77回日本循環器学会学術集会  2013.3 

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    Venue:横浜  

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  • J波と心室再分極指標に対する自律神経興奮の関与:ホルター心電図を用いた検討

    齋藤修, 池主雅臣, 鈴木克弥, 杉浦広隆, 阿部暁, 樋口浩太郎, 大塚英明

    第29回日本心電学会学術集会  2012.10 

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    Venue:千葉  

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  • ホルター心電図検査を用いてのJ波定量評価と自律神経興奮の関与の検討

    齋藤修, 池主雅臣, 杉浦広隆, 阿部暁, 樋口浩太郎, 大塚英明

    第32回日本ホルター・ノンインベイシブ心電学研究会  2012.6 

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    Venue:新潟  

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  • 新潟県内施設における頸動脈エコー検査法の現状 -頚動脈エコー検査に関するアンケート集計結果-

    小林清子, 齋藤修, 宮崎智美, 佐藤梨紗, 八木恵子, 平山智香子, 金子玲子, 渡邊博昭, 山崎まゆみ, 桑原喜久男

    第61回日本医学検査学会  2012.6 

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    Venue:三重  

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  • 加算平均心電図を応用したBrugada症候群と健常群の興奮伝導の評価

    鈴木克弥, 池主雅臣, 古田由衣, 古嶋博司, 飯島賢一, 和泉大輔, 佐藤光希, 石田尚子, 齋藤修

    第32回日本ホルター・ノンインベイシブ心電学研究会  2012.6 

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    Venue:新潟  

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  • Brugada症候群例と健常例の心内興奮伝導分布:加算平均心電図を用いた検討

    鈴木克弥, 池主雅臣, 古田由衣, 古嶋博司, 飯島賢一, 和泉大輔, 佐藤光希, 齋藤修

    第76回日本循環器学会学術集会  2011.8 

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    Venue:横浜  

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  • 発作性心房細動・Brugada症候群・高血圧症例の心房内伝導遅延の評価 (心房加算平均心電図を用いた検討)

    古田由衣, 池主雅臣, 鈴木克弥, 古嶋博司, 飯嶋賢一, 和泉大輔, 佐藤光希, 石田尚子, 齋藤修

    第76回日本循環器学会学術集会  2011.8 

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    Venue:横浜  

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  • Hemodynamic and Histological Effects of Radiofrequency Catheter Ablation to Renal Artery

    Masaomi Chinushi, Daisuke Izumi, Kenichi Iijima, Kanae Hasegawa, Katsuya Suzuki, Yui Furuta, Michiko Tada, Osamu Saitoh, Haruna Honma, Hiroshi Furushima, Mitsuya Iwafuchi, Yoshifusa Aizawa

    第76回日本循環器学会学術集会  2011.8 

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    Venue:横浜  

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  • 左室壁運動が低下した僧帽弁狭窄症で弁置換術後の経時的変化を検討した1例

    山崎真奈美, 大矢佳奈, 桑原博幸, 辻恵子, 齋藤修, 樋口浩太郎, 大塚英明

    第50回東北医学検査学会学術集会  2009.11 

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    Venue:秋田  

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  • 大動脈弁置換後の左心機能回復過程を心エコー図にて観察した2例

    辻恵子, 山崎真奈美, 大矢佳奈, 桑原博幸, 齋藤修, 樋口浩太郎, 大塚英明

    第49回東北医学検査学会学術集会  2008.11 

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    Venue:新潟  

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  • ペーシング療法後、圧較差に変動を認めた閉塞性肥大型心筋症の一例

    大矢佳奈, 山崎真奈美, 桑原博幸, 辻恵子, 齋藤修, 樋口浩太郎, 大嶋有希子, 阿部暁, 大塚英明

    第33回日本超音波検査学会学術集会  2008.6 

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    Venue:前橋  

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  • 左前下行枝を責任病変とする急性心筋梗塞患者における左室壁運動の評価

    齋藤修, 山崎真奈美, 大矢佳奈, 桑原博幸, 辻恵子, 樋口浩太郎, 杉浦香奈子, 阿部暁, 大塚英明

    第30回日本心血管インターベンション治療学会関東甲信越地方会  2007.5 

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    Venue:新潟  

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  • 深部心筋焼灼に用いるHalf-Normal Saline灌流通電法(HNS)とバイポーラ通電法(BIP)の比較:効果と安全性の実験的検討

    笠井琢充, 齋藤修, 布施亨伍, 竹内天南, 小林紘子, 及川綾花, 古嶋博司, 池主雅臣

    日本不整脈心電学会カテーテルアブレーション関連秋季大会2023 

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    Language:Japanese   Presentation type:Oral presentation (general)  

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Awards

  • メディカルプロフェッショナルBest Abstract Award 優秀賞

    2021.9   日本不整脈心電学会カテーテルアブレーション関連秋季大会  

    齋藤 修

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  • 第1回国立大学臨床検査学系博士後期課程優秀賞

    2017.3  

    齋藤 修

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  • 第6回コメディカル最優秀賞

    2016.3   日本循環器学会  

    齋藤 修

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  • 優秀演題賞

    2014.6   日本ホルター・ノンインベイシブ心電学研究会  

    齋藤 修

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  • コメディカルセッション優秀賞

    2012.10   日本心電学会  

    齋藤 修

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Research Projects

  • 貫通性焼灼を安全に完遂する多角的モニタリング法と出力調整長時間通電法の構築

    Grant number:23K07502

    2023.4 - 2026.3

    System name:科学研究費助成事業

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    齋藤 修, 池主 雅臣

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

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  • 深部心筋に安定焼灼傷を形成する高周波通電法構築(抵抗伝導加熱と灌流冷却の適正化)

    Grant number:22K08096

    2022.4 - 2025.3

    System name:科学研究費助成事業 基盤研究(C)

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    池主 雅臣, 齋藤修

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    冠動脈灌流によって拍動収縮する食用豚心筋切片モデルを用いて、心筋興奮指標(局所電位、興奮閾値、興奮伝搬)・工学電気指標(電流・電圧・インピーダンス)をモニターして高周波通電ができるオリジナル実験系で、深部心筋に安定した焼灼傷を形成する通電法の構築を進めている。2022年は通電中のインピーダンス変化に応じて高周波出力を調整するインピーダンスガイドパワーコントロール(IGPC)法を考案し、その有効性と安全性を検証した。IGPC法は通電中のインピーダンスの過剰低下を予防することができ、従来の固定出力法に比べて心筋貫壁性焼灼傷を安全に形成することができた。実験ではIGPC法が同一仕事量の固定出力法に比して、貫壁性焼灼傷の形成成功率が高く、スチームポップによる合併症も回避できる事が検証された。またその理由はIGPC法が伝導加熱を有効利用しているためと考えられた。これらの成果は専門誌と関連学会に報告した。
    高周波アブレーション治療後の不整脈再発は不十分な心筋加熱にある。心筋は一定時間50℃以上に加熱されると安定した焼灼傷に至るが、不十分加熱の場合は一時的に抑制された興奮伝導が術後に回復して不整脈の再発に至る。高周波アブレーションに用いられるイリゲーションカテーテルは、カテーテル接触心筋の過度な温度上昇を防ぐため、生理食塩水噴射でカテーテル先端を冷却しながら通電を行う。イリゲーションカテーテルでは通電開始初期の最大温度上昇点は心筋表面よりやや深部となる。このため不十分出力で短時間通電を行った場合、治療直後に抑制された心筋表面の興奮伝導が再伝導を生じる事を実験的に検証した。またこの再発現象は通電時間を適正化する事で予防できることを確認して関連学会で報告した。

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  • Electrophysiological characteristics of ventricular arrhythmias developed in hypothermic conditions.

    Grant number:19K08574

    2019.4 - 2022.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Saitoh Osamu

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    This study was performed to clarify hypothermia arrhythmias' electrophysiological and excitatory characteristics using the porcine heart model.
    The main findings of this study were as follows; suppressed automaticity, slowed conduction, prolonged repolarization, more heterogeneous distribution of repolarization, higher pacing stimulus threshold and reduced cardiac contraction were observed as myocardial temperature decreased (37, 32, 28℃). In addition, ventricular arrhythmias were most frequently induced at 28 ℃ by programmed electrical stimulation. Ventricular fibrillation in advanced hypothermia was accompanied by an increased defibrillation threshold and decreased dominant frequency and power.
    These results seemed to be characterized as therapy-resistant ventricular arrhythmias in the advanced hypothermic condition.

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  • Radiofrequency ablation of ventricular arrhythmias arising from deep myocardium (coronary perfused beating hearts in the dual-bath experimental setting)

    Grant number:19K08512

    2019.4 - 2022.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Chinushi Masaomi

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Using an experimental model of porcine myocardium that beat and contract with coronary perfusion, we constructed an experimental system in which radiofrequency ablation can be performed while monitoring myocardial excitation (local potential, excitation threshold and electrocardiogram), delivering electrical parameters (current, voltage, and impedance), and ultrasound imaging information.
    The following approaches were considered effective in improving ablation efficiency; (1) use of the Bipolar ablation method, and (2) appropriately long application time for maximizing the conduction heating effect. Short-time application using irrigation catheter may restore the excitation of superficial myocardium. Important items to ensure safety were as follows; (1) avoid high power energy delivered by Bipolar ablation method for thin myocardial areas to prevent steam-pop, and (2) limit total impedance drop during ablation within 20-25 ohm

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  • Establishment of safe and effective indices of bipolar radiofrequency ablation for the treatment of intractable arrhythmias

    Grant number:16K09424

    2016.4 - 2019.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Saitoh Osamu

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    This study was performed to identify safe and effective use of bipolar radiofrequency (RF) ablation in clinical treatment. The main findings are (1) results of our dual-bath experimental model suggested that RF lesions in human hearts seemed to be larger than that expected from the findings from conventional single-bath experimental models, (2) steam-pop phenomenon was accompanied with a greater impedance decrease as compared to that in absence of steam-pop, (3) lesion depth was well correlated with the integral value of time-dependent decreases in impedance, and (4) as compared to delivering high energy-for a short duration, a longer application time with moderate energy seems to be much safer to create a reasonable lesion depth without steam-pop phenomenon.

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Teaching Experience (researchmap)

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Teaching Experience

  • 病態生理機能学実習

    2021
    Institution name:新潟大学

  • 医療英語ベーシック(検査)

    2021
    Institution name:新潟大学

  • 保健学総合

    2021
    Institution name:新潟大学

  • スタディスキルズ (検査)

    2020
    Institution name:新潟大学

  • 呼吸機能検査科学

    2020
    Institution name:新潟大学

  • 医療安全管理学

    2018
    Institution name:新潟大学

  • 医療英語(検査)

    2016
    Institution name:新潟大学

  • 病態生理機能学特論

    2016
    Institution name:新潟大学

  • 医学検査管理総論

    2016
    Institution name:新潟大学

  • 臨床検査実習

    2016
    Institution name:新潟大学

  • 臨床検査管理概論

    2016
    -
    2018
    Institution name:新潟大学

  • 病態生理機能学実習

    2016
    -
    2018
    Institution name:新潟大学

  • 卒業研究

    2015
    Institution name:新潟大学

  • 人体機能構造学Ⅱ

    2015
    Institution name:新潟大学

  • 人体の構造と機能Ⅰ

    2015
    Institution name:新潟大学

  • 循環器機能検査科学

    2015
    Institution name:新潟大学

  • 生活習慣と健康

    2015
    Institution name:新潟大学

  • 医用工学概論

    2015
    Institution name:新潟大学

  • 医用工学実習

    2015
    Institution name:新潟大学

  • 情報科学概論演習

    2015
    Institution name:新潟大学

  • 生体機能学実習

    2014
    Institution name:新潟大学

  • 生理機能検査科学実習

    2014
    Institution name:新潟大学

  • 保健学総合

    2014
    -
    2021
    Institution name:新潟大学

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