2024/10/12 更新

写真a

ラズビナ オリガ
RAZVINA OLGA
RAZVINA OLGA
所属
教育研究院 医歯学系 医学系列 助教
医歯学総合研究科 助教
職名
助教
外部リンク

学位

  • 博士(医学) ( 2014年3月   新潟大学 )

研究分野

  • その他 / その他

経歴

  • 新潟大学   医歯学総合研究科   助教

    2021年4月 - 現在

  • 新潟大学   教育研究院 医歯学系 医学系列   助教

    2021年4月 - 現在

  • 新潟大学   医歯学総合研究科   特任助教

    2015年1月 - 2021年3月

 

論文

  • A strategy for low-cost portable monitoring of plasma drug concentrations using a sustainable boron-doped-diamond chip

    Takuro Saiki, Genki Ogata, Seishiro Sawamura, Kai Asai, Olga Razvina, Kota Watanabe, Rito Kato, Qi Zhang, Koei Akiyama, Sasya Madhurantakam, Norzahirah Binti Ahmad, Daisuke Ino, Haruma Nashimoto, Yoshifumi Matsumoto, Masato Moriyama, Arata Horii, Chie Kondo, Ryosuke Ochiai, Hiroyuki Kusuhara, Yasuo Saijo, Yasuaki Einaga, Hiroshi Hibino

    Heliyon   9 ( 5 )   2023年5月

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    掲載種別:研究論文(学術雑誌)  

    On-site monitoring of plasma drug concentrations is required for effective therapies. Recently developed handy biosensors are not yet popular owing to insufficient evaluation of accuracy on clinical samples and the necessity of complicated costly fabrication processes. Here, we approached these bottlenecks via a strategy involving engineeringly unmodified boron-doped diamond (BDD), a sustainable electrochemical material. A sensing system based on a ∼1 cm2 BDD chip, when analysing rat plasma spiked with a molecular-targeting anticancer drug, pazopanib, detected clinically relevant concentrations. The response was stable in 60 sequential measurements on the same chip. In a clinical study, data obtained with a BDD chip were consistent with liquid chromatography–mass spectrometry results. Finally, the portable system with a palm-sized sensor containing the chip analysed ∼40 μL of whole blood from dosed rats within ∼10 min. This approach with the ‘reusable’ sensor may improve point-of-monitoring systems and personalised medicine while reducing medical costs.

    DOI: 10.1016/j.heliyon.2023.e15963

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  • Analysis of Pharmacokinetics in the Cochlea of the Inner Ear 査読

    Seishiro Sawamura, Genki Ogata, Kai Asai, Olga Razvina, Takeru Ota, Qi Zhang, Sasya Madhurantakam, Koei Akiyama, Daisuke Ino, Sho Kanzaki, Takuro Saiki, Yoshifumi Matsumoto, Masato Moriyama, Yasuo Saijo, Arata Horii, Yasuaki Einaga, Hiroshi Hibino

    Frontiers in Pharmacology   12   2021年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Frontiers Media SA  

    Hearing loss affects >5% of the global population and therefore, has a great social and clinical impact. Sensorineural hearing loss, which can be caused by different factors, such as acoustic trauma, aging, and administration of certain classes of drugs, stems primarily from a dysfunction of the cochlea in the inner ear. Few therapeutic strategies against sensorineural hearing loss are available. To develop effective treatments for this disease, it is crucial to precisely determine the behavior of ototoxic and therapeutic agents in the microenvironment of the cochlea in live animals. Since the 1980s, a number of studies have addressed this issue by different methodologies. However, there is much less information on pharmacokinetics in the cochlea than that in other organs; the delay in ontological pharmacology is likely due to technical difficulties with accessing the cochlea, a tiny organ that is encased with a bony wall and has a fine and complicated internal structure. In this review, we not only summarize the observations and insights obtained in classic and recent studies on pharmacokinetics in the cochlea but also describe relevant analytical techniques, with their strengths, limitations, and prospects.

    DOI: 10.3389/fphar.2021.633505

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  • Differential expression of pentraxin 3 in neutrophils 査読

    Olga Razvina, Shuying Jiang, Koichi Matsubara, Riuko Ohashi, Go Hasegawa, Takashi Aoyama, Kenji Daigo, Tatsuhiko Kodama, Takao Hamakubo, Makoto Naito

    EXPERIMENTAL AND MOLECULAR PATHOLOGY   98 ( 1 )   33 - 40   2015年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Pentraxins belong to the superfamily of conserved proteins that are characterized by a cyclic multimeric structure. Pentraxin 3 (PTX3) is a long pentraxin which can be produced by different cell types upon exposure to various inflammatory signals. Inside the neutrophil PTX3 is stored in form of granules localized in the cytoplasm. Neutrophilic granules are divided into three types: azurophilic (primary) granules, specific (secondary) granules and gelatinase (tertiary) granules. PTX3 has been considered to be localized in specific (secondary) granules. Immunofluorescent analyses using confocal laser microscopic examination were performed to clarify the localization of all three groups of granules within the cytoplasm of the mature neutrophils and neutrophils stimulated with IL-8. Furthermore, PTX3 was localized in primary granules of promyelocyte cell line HL-60. As a result, we suggest that PTX3 is localized not only in specific granules, but is also partly expressed in primary and tertiary granules. After the stimulation with IL-8, irregular reticular structures called neutrophil extracellular traps (NETs) were formed, three types of granules were trapped by NETs and PTX3 showed partial colocalization with these granular components. PTX3 localized in all three types of granules in neutrophils may play important roles in host defense. (C) 2014 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.yexmp.2014.11.009

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  • Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance 査読

    Tatsuo Yamamoto, Akihito Nishiyama, Tomomi Takano, Shizuka Yabe, Wataru Higuchi, Olga Razvina, Da Shi

    JOURNAL OF INFECTION AND CHEMOTHERAPY   16 ( 4 )   225 - 254   2010年8月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    Methicillin-resistant Staphylococcus aureus (MRSA) is able to persist not only in hospitals (with a high level of antimicrobial agent use) but also in the community (with a low level of antimicrobial agent use). The former is called hospital-acquired MRSA (HA-MRSA) and the latter community-acquired MRSA (CA-MRSA). It is believed MRSA clones are generated from S. aureus through insertion of the staphylococcal cassette chromosome mec (SCCmec), and outbreaks occur as they spread. Several worldwide and regional clones have been identified, and their epidemiological, clinical, and genetic characteristics have been described. CA-MRSA is likely able to survive in the community because of suitable SCCmec types (type IV or V), a clone-specific colonization/infection nature, toxin profiles (including Pantone-Valentine leucocidin, PVL), and narrow drug resistance patterns. CA-MRSA infections are generally seen in healthy children or young athletes, with unexpected cases of diseases, and also in elderly inpatients, occasionally surprising clinicians used to HA-MRSA infections. CA-MRSA spreads within families and close-contact groups or even through public transport, demonstrating transmission cores. Re-infection (including multifocal infection) frequently occurs, if the cores are not sought out and properly eradicated. Recently, attention has been given to CA-MRSA (USA300), which originated in the US, and is growing as HA-MRSA and also as a worldwide clone. CA-MRSA infection in influenza season has increasingly been noted as well. MRSA is also found in farm and companion animals, and has occasionally transferred to humans. As such, the epidemiological, clinical, and genetic behavior of CA-MRSA, a growing threat, is focused on in this study.

    DOI: 10.1007/s10156-010-0045-9

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  • Emergence of the community-acquired methicillin-resistant Staphylococcus aureus USA300 clone in a Japanese child, demonstrating multiple divergent strains in Japan 査読

    Wataru Higuchi, Shigenao Mimura, Yoshihiro Kurosawa, Tomomi Takano, Yasuhisa Iwao, Shizuka Yabe, Olga Razvina, Akihito Nishiyama, Yurika Ikeda-Dantsuji, Fuminori Sakai, Hideaki Hanaki, Tatsuo Yamamoto

    JOURNAL OF INFECTION AND CHEMOTHERAPY   16 ( 4 )   292 - 297   2010年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER TOKYO  

    In 2008 we isolated methicillin-resistant Staphylococcus aureus (MRSA) from an 11-month-old Japanese girl who lived in Saitama, Japan, and suffered from cellulitis of the lower thigh and sepsis. The MRSA (strain NN47) belonged to multilocus sequence type (ST) 8 and exhibited spa363 (t024), agr1, staphylococcal cassette chromosome mec (SCCmec) type IVa, and coagulase type III. It was positive for Panton-Valentine leukocidin (PVL) and the arginine catabolic mobile element (ACME). Pulsed-field gel electrophoresis (PFGE) demonstrated that the MRSA was the USA300 clone, which is the predominant community-acquired MRSA (CA-MRSA) in the US. Strain NN47 was divergent, in terms of the spa type and patterns of PFGE and plasmids, from the USA300-0114 type strain or USA300 strain NN36, previously isolated from a visitor (Indian girl) from the US. Strain NN47 was resistant to erythromycin, in addition to beta-lactam agents (e.g., oxacillin). These data demonstrate the first emergence of the USA300 clone in Japanese children who have never been abroad and have had no contact with foreigners (and therefore, the first USA300 spread in Japan), and also emergence of multiple divergent strains of the USA300 clone in Japan. Because the USA300 clone is highly transmissible and virulent, surveillance of the USA300 clone is needed.

    DOI: 10.1007/s10156-010-0051-y

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  • Molecular typing of Campylobacter jejuni and C. coli from chickens and patients with gastritis or Guillain-Barré syndrome based on multilocus sequence types and pulsed-field gel electrophoresis patterns. 査読

    Yabe S, Higuchi W, Iwao Y, Takano T, Razvina O, Reva I, Nishiyama A, Yamamoto T

    Microbiology and immunology   54 ( 6 )   362 - 367   2010年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1348-0421.2010.00222.x

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  • In vitro susceptibility to antimicrobial agents and ultrastructural characteristics related to swimming motility and drug action in Campylobacter jejuni and C. coli 査読

    Shizuka Yabe, Wataru Higuchi, Tomomi Takano, Olga Razvina, Yasuhisa Iwao, Hirokazu Isobe, Tatsuo Yamamoto

    JOURNAL OF INFECTION AND CHEMOTHERAPY   16 ( 3 )   174 - 185   2010年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER TOKYO  

    Campylobacter jejuni has recently been noted as the most common cause of bacterial food-borne diseases in Japan. In this study, we examined in vitro susceptibility to 36 antimicrobial agents of 109 strains of C. jejuni and C. coli isolated from chickens and patients with enteritis or Guillain-Barr, syndrome from 1996 to 2009. Among these agents, carbapenems (imipenem, meropenem, panipenem, and biapenem) showed the greatest activity [minimal inhibitory concentration (MIC)(90), 0.03-0.125 mu g/ml]. This was followed by sitafloxacin (MIC(90), 0.25 mu g/ml), furazolidone and azithromycin (MIC(90), 0.5 mu g/ml), gentamicin and clindamycin (MIC(90), 1 mu g/ml), and clavulanic acid (beta-lactamase inhibitor; MIC(90), 2 mu g/ml). All or most strains were resistant to aztreonam, sulfamethoxazole, and trimethoprim. Marked resistance was also observed for levofloxacin and tetracyclines. Resistance was not present for macrolides and rare for clindamycin. C. jejuni (and C. coli) exhibited high swimming motility and possessed a unique end-side (cup-like) structure at both ends, in contrast to Helicobacter pylori and Vibrio cholerae O1 and O139. The morphology of C. jejuni (and C. coli) changed drastically after exposure to imipenem (coccoid formation), meropenem (bulking and slight elongation), and sitafloxacin (marked elongation), and exhibited reduced motility. In the HEp-2 cell adherence model, unusually elongated bacteria were also observed for sitafloxacin. The data suggest that although resistance to antimicrobial agents (e.g., levofloxacin) has continuously been noted, carbapenems, sitafloxacin, and others such as beta-lactamase inhibitors alone showed good in vitro activity and that C. jejuni (and C. coli) demonstrated a unique ultrastructural nature related to high swimming motility and drug action.

    DOI: 10.1007/s10156-010-0040-1

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MISC

  • COVID-19パンデミックにおける教育実践 遠隔同期型の多職種連携教育における学修効果の解析

    河内 泉, 中島 寛音, 中嶋 大和, 青木 亜美, Olga Razvina, 福井 直樹, 齋藤 昭彦, 土田 正則, 佐藤 昇, 染矢 俊幸

    医学教育   53 ( Suppl. )   158 - 158   2022年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • ロシア医学生外科オリンピックから学ぶシミュレーション医学教育

    伊藤 正洋, 若槻 華子, 加畑 雄大, Razvina Olga, 山川 詩保子, 澁谷 雅子, 日比野 浩, Tashkinov Nikolai V, 土田 正則, 佐藤 昇, 鈴木 利哉, 牛木 辰男

    日本シミュレーション医療教育学会雑誌   5   89 - 92   2017年8月

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    記述言語:日本語   出版者・発行元:日本シミュレーション医療教育学会  

    ロシア極東医科大学で開催された"Student Surgical Olympiad"極東地区予選に参加した。大会は、学生の外科領域への興味を促すこと、外科領域へ進むことを希望する学生に早期から実践的外科技術を修得させることを目的としていた。大会は外科手技を中心とした16課題で3日間に渡り行われ、上位2チームにはモスクワで行われる本選への出場権が与えられた。課題達成に必要な医療知識、手技は臨床に即した内容であった。参加学生の熱意は非常に高く、学生外科サークルを通じた事前の十分な準備により、課題への対応が可能となっていた。専門性の高い知識、技能を低学年から修得するためのサポート体制、学生オリンピックの開催は、シミュレーション教育の普及、進歩に寄与し、学生の能動的学習を促す効果がある。(著者抄録)

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  • 外科卒前教育改善の参考となるロシア医学生外科オリンピック

    伊藤 正洋, 鈴木 利哉, 澁谷 雅子, 山川 詩保子, Olga Razvina, 日比野 浩, 土田 正則, 佐藤 昇, 牛木 辰男

    医学教育   48 ( Suppl. )   186 - 186   2017年8月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • 実践報告(海外) ロシア医学生外科オリンピックから学ぶシミュレーション医学教育

    伊藤 正洋, 若槻 華子, 加畑 雄大, Razvina Olga, 山川 詩保子, 澁谷 雅子, 日比野 浩, Tashkinov Nikolai V, 土田 正則, 佐藤 昇, 鈴木 利哉, 牛木 辰男

    日本シミュレーション医療教育学会雑誌 = Journal of Japan Association for Simulation-based Education in Healthcare Professionals   5   89 - 92   2017年

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    記述言語:日本語   出版者・発行元:日本シミュレーション医療教育学会  

    ロシア極東医科大学で開催された"Student Surgical Olympiad"極東地区予選に参加した。大会は、学生の外科領域への興味を促すこと、外科領域へ進むことを希望する学生に早期から実践的外科技術を修得させることを目的としていた。大会は外科手技を中心とした16課題で3日間に渡り行われ、上位2チームにはモスクワで行われる本選への出場権が与えられた。課題達成に必要な医療知識、手技は臨床に即した内容であった。参加学生の熱意は非常に高く、学生外科サークルを通じた事前の十分な準備により、課題への対応が可能となっていた。専門性の高い知識、技能を低学年から修得するためのサポート体制、学生オリンピックの開催は、シミュレーション教育の普及、進歩に寄与し、学生の能動的学習を促す効果がある。(著者抄録)

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  • 重症筋無力症と心肥大とを合併した1剖検例

    Razvina Olga, 長谷川 剛, 近藤 英作

    日本病理学会会誌   104 ( 1 )   330 - 330   2015年3月

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    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

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  • 腎移植 Q & A

    Kiselev Ilia, Protopopova Elena, Shermatova Ksenia, 斎藤 和英, 高橋 公太, 岩尾 泰久, 樋口 渉, Reva Ivan, Razvina Olga, 高野 智洋, 西山 晃史, 山本 達男, Kiselev Ilia, Protopopova Elena, Shermatova Ksenia, Saito Kazuhide, Takahashi Kota, Iwao Yasuhisa, Higuchi Wataru, Reva Ivan, Razvina Olga, Takano Tomomi, Nishiyama Akihito, Yamamoto Tatsuo

    新潟医学会雑誌   125 ( 10 )   571 - 574   2011年10月

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    記述言語:日本語   出版者・発行元:新潟医学会  

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  • ロシア及び日本の小児白血病, パーキンソン病, そして癌手術について

    Podkaura Oxana, Gavrikova Valeria, Korneev Stanislav, 今井 千速, 内山 聖, 村上 博淳, 増田 浩, 黒羽 泰子, 小池 亮子, 内山 政二, 小杉 伸一, 畠山 勝義, Razvina Olga, Reva Ivan, 髙野 智洋, 西山 晃史, 山本 達男, Podkaura Oxana, Gavrikova Valeria, Korneev Stanislav, Imai Chihaya, Uchiyama Makoto, Murakami Hiroatsu, Masuda Hiroshi, Kuroha Yasuko, Koike Ryoko, Uchiyama Seiji, Kosugi Shinichi, Hatakeyama Katsuyoshi, Razvina Olga, Reva Ivan, Takano Tomomi, Nishiyama Akihito, Yamamoto Tatsuo

    新潟医学会雑誌   124 ( 4 )   228 - 234   2010年4月

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    記述言語:日本語   出版者・発行元:新潟医学会  

    The aim of young doctor exchange program was to exchange Japanese and Russian young doctors who have just graduated and to share experiences and knowledge in both clinical and basic fields. Oxana Podkaura (from Vladivostok), Valeria Gavrikova (from Krasnoyarsk) and Stanislav Korneev (from Khabarovsk) took part in this program held in Niigata from September 4 to 18, and studied children's leukemia and its treatment, Parkinson's disease and its treatment, and surgical treatment of liver, gastric and intestine cancer, respectively. They also attended two international symposia, CHRO2009 in Niigata and 2009 Tripartite symposium (Russia-United States-Japan Symposium on Cardiovascular Disease and Cancer) in Osaka.

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  • アジアとロシアに分布するメチシリン耐性黄色ブドウ球菌 Hungarian cloneのmultiplex PCRによる迅速検出

    Khokholova Olga, Wei Chun Hung, Lee Jene Teng, 樋口 渉, Razvina Olga, 高野 智洋, 山本 達男, Khokholova Olga, Wei Chun Hung, Lee Jene Teng, Higuchi Wataru, Razvina Olga, Takano Tomomi, Yamamoto Tatsuo

    新潟医学会雑誌   124 ( 3 )   167 - 170   2010年3月

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    記述言語:日本語   出版者・発行元:新潟医学会  

    Dr. Olga Khokholova from Krasnoyarsk (Russia) took part in the young doctor program, a new Japan-Russia exchange program started in 2008, and studied methicillin-resistant Staphylococcus aureus (MRSA), in collaboration with young scientists from National Taiwan University and Niigata University. The Hungarian MRSA clone (and related clones) is a major pandemic clone spreading worldwide including Europe, South America, Africa, Asia, and Russia. In this study, we developed the multiplex PCR targeting the combination of the five genes (nuc, mecA, sea, cna), which were present only in the Hungarian clone, and unambiguously distinguished the Hungarian clone from other pandemic MRSA clones, such as the New York/Japan clone.

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  • ロシアでの感染症の現状

    寺田 倫子, 日紫喜 万理子, 小林 聡, Razvina Olga, Korshunova Natalia, Peryanova Olga, Salmina Alla, Reva Ivan, 樋口 渉, 山本 達男, Terada Michiko, Hishiki Mariko, Kobayashi Satoshi, Higuchi Wataru, Tatsuo Yamamoto

    新潟医学会雑誌   123 ( 4 )   188 - 192   2009年4月

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    記述言語:日本語   出版者・発行元:新潟医学会  

    日露医学生交流の一環として, 寺田 (学部3年) と小林 (学部4年) はロシアの極東医科大学を, 日紫喜 (学部3年) はクラスノヤルスク医科大学を訪問し, ロシアでの医学教育に触れ, ロシア医療を学んだ. 本稿では特に感染症をとりあげ, ロシアでの過去5年間の感染症動向をまとめた. 感染症は一般に減少傾向を示したが, 依然高水準を示す感染症や社会問題と関連して深刻化した感染症なども存在した.

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受賞

  • The young Scientist Award (Japan-Russia International Workshop)

    2010年5月  

    らずびな おりが

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  • CHRO Promotion Award (the 15th Campylobacter, Helicobacter and Related Microorganisms conference)

    2009年10月  

    らずびな おりが

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担当経験のある授業科目

  • 医学英語II

    2023年
    -
    現在
    機関名:新潟大学

  • 学問の扉 知と方法の最前線

    2022年
    -
    現在
    機関名:新潟大学

  • 早期医学体験実習(EME)

    2022年
    -
    現在
    機関名:新潟大学

  • 医学研究実習

    2022年
    -
    現在
    機関名:新潟大学

  • 医学英語I

    2021年
    -
    現在
    機関名:新潟大学

  • チーム医療実践論

    2021年
    機関名:新潟大学

  • 基礎臨床統合Ⅰ

    2020年
    -
    現在
    機関名:新潟大学

  • 統合臨床医学

    2020年
    -
    現在
    機関名:新潟大学

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