2022/12/01 更新

写真a

アダチ ユウスケ
足立 雄哉
ADACHI Yusuke
所属
教育研究院 医歯学系 医学系列 助教
医歯学総合研究科 生体機能調節医学専攻 感覚統合医学 助教
職名
助教
外部リンク

学位

  • 博士(理学) ( 2012年2月   東京大学 )

研究分野

  • ライフサイエンス / 認知脳科学

経歴(researchmap)

  • 新潟大学大学院 医歯学総合研究科   神経生理学   助教

    2015年 - 現在

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  • 東京大学大学院 医学系研究科   統合生理学   助教

    2012年 - 2015年

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  • 東京大学大学院 医学系研究科   統合生理学   特任助教

    2007年 - 2012年

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  • 日本学術振興会   特別研究員(DC1)

    2004年 - 2007年

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経歴

  • 新潟大学   医歯学総合研究科 生体機能調節医学専攻 感覚統合医学   助教

    2015年8月 - 現在

  • 新潟大学   医歯学総合研究科 生体機能調節医学専攻 感覚統合医学   助教

    2015年2月 - 2015年7月

学歴

  • 東京大学   理学系研究科   物理学専攻博士課程

    2004年 - 2007年

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  • 東京大学   理学系研究科   物理学専攻修士課程

    2002年 - 2004年

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  • 東京大学   理学部   物理学科

    2000年 - 2002年

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論文

  • Development of a Self-paced Sequential Letterstring Reading Task to Capture the Temporal Dynamics of Reading a Natural Language 査読

    Ryutaro Kasedo, Atsuhiko Iijima, Kiyoshi Nakahara, Yusuke Adachi, Isao Hasegawa

    Advanced Biomedical Engineering   10   26 - 31   2021年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Japanese Society for Medical and Biological Engineering  

    DOI: 10.14326/abe.10.26

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  • マカクザル及びヒトの質的・量的な因果構造理解に基づく自己に関わる出来事の原因帰属行動

    阿部 湧, 足立 雄哉, 田村 滉樹, 齊藤 孝臣, 飯島 淳彦, 長谷川 功

    日本生理学雑誌   82 ( 1 )   11 - 11   2020年2月

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    記述言語:日本語   出版者・発行元:(一社)日本生理学会  

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  • 1文字連続呈示課題を用いた文理解中の2重構造化処理に寄与する神経基盤の解明

    加世堂 竜太郎, 飯島 淳彦, 中原 潔, 足立 雄哉, 長谷川 功

    日本生理学雑誌   82 ( 1 )   12 - 12   2020年2月

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    記述言語:日本語   出版者・発行元:(一社)日本生理学会  

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  • Dynamic laminar rerouting of inter-areal mnemonic signal by cognitive operations in primate temporal cortex. 査読 国際誌

    Masaki Takeda, Toshiyuki Hirabayashi, Yusuke Adachi, Yasushi Miyashita

    Nature communications   9 ( 1 )   4629 - 4629   2018年11月

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    記述言語:英語  

    Execution of cognitive functions is orchestrated by a brain-wide network comprising multiple regions. However, it remains elusive whether the cortical laminar pattern of inter-areal interactions exhibits dynamic routings, depending on cognitive operations. We address this issue by simultaneously recording neuronal activities from area 36 and area TE of the temporal cortex while monkeys performed a visual cued-recall task. We identify dynamic laminar routing of the inter-areal interaction: during visual processing of a presented cue, spiking activities of area 36 neurons are preferentially coherent with local field potentials at the supragranular layer of area TE, while the signal from the same neurons switches to target the infragranular layer of area TE during memory retrieval. This layer-dependent signal represents the to-be-recalled object, and has an impact on the local processing at the supragranular layer in both cognitive operations. Thus, cortical layers form a key structural basis for dynamic switching of cognitive operations.

    DOI: 10.1038/s41467-018-07007-1

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    その他リンク: http://orcid.org/0000-0001-8697-994X

  • Causal neural network of metamemory for retrospection in primates 査読

    Kentaro Miyamoto, Takahiro Osada, Rieko Setsuie, Masaki Takeda, Keita Tamura, Yusuke Adachi, Yasushi Miyashita

    SCIENCE   355 ( 6321 )   188 - 193   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER ASSOC ADVANCEMENT SCIENCE  

    We know how confidently we know: Metacognitive self-monitoring of memory states, so-called "metamemory," enables strategic and efficient information collection based on past experiences. However, it is unknown how metamemory is implemented in the brain. We explored causal neural mechanism of metamemory in macaque monkeys performing metacognitive confidence judgments on memory. By whole-brain searches via functional magnetic resonance imaging, we discovered a neural correlate of metamemory for temporally remote events in prefrontal area 9 (or 9/46d), along with that for recent events within area 6. Reversible inactivation of each of these identified loci induced doubly dissociated selective impairments in metacognitive judgment performance on remote or recent memory, without impairing recognition performance itself. The findings reveal that parallel metamemory streams supervise recognition networks for remote and recent memory, without contributing to recognition itself.

    DOI: 10.1126/science.aal0162

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  • Dynamically Allocated Hub in Task-Evoked Network Predicts the Vulnerable Prefrontal Locus for Contextual Memory Retrieval in Macaques 査読

    Takahiro Osada, Yusuke Adachi, Kentaro Miyamoto, Koji Jimura, Rieko Setsuie, Yasushi Miyashita

    PLOS BIOLOGY   13 ( 6 )   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Neuroimaging and neurophysiology have revealed that multiple areas in the prefrontal cortex (PFC) are activated in a specific memory task, but severity of impairment after PFC lesions is largely different depending on which activated area is damaged. The critical relationship between lesion sites and impairments has not yet been given a clear mechanistic explanation. Although recent works proposed that a whole-brain network contains hubs that play integrative roles in cortical information processing, this framework relying on an anatomy-based structural network cannot account for the vulnerable locus for a specific task, lesioning of which would bring impairment. Here, we hypothesized that (i) activated PFC areas dynamically form an ordered network centered at a task-specific "functional hub" and (ii) the lesion-effective site corresponds to the "functional hub," but not to a task-invariant "structural hub." To test these hypotheses, we conducted functional magnetic resonance imaging experiments in macaques performing a temporal contextual memory task. We found that the activated areas formed a hierarchical hub-centric network based on task-evoked directed connectivity, differently from the anatomical network reflecting axonal projection patterns. Using a novel simulated-lesion method based on support vector machine, we estimated severity of impairment after lesioning of each area, which accorded well with a known dissociation in contextual memory impairment in macaques (impairment after lesioning in area 9/46d, but not in area 8Ad). The predicted severity of impairment was proportional to the network "hubness" of the virtually lesioned area in the task-evoked directed connectivity network, rather than in the anatomical network known from tracer studies. Our results suggest that PFC areas dynamically and cooperatively shape a functional hub-centric network to reallocate the lesion-effective site depending on the cognitive processes, apart from static anatomical hubs. These findings will be a foundation for precise prediction of behavioral impacts of damage or surgical intervention in human brains.

    DOI: 10.1371/journal.pbio.1002177

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  • Top-Down Regulation of Laminar Circuit via Inter-Area Signal for Successful Object Memory Recall in Monkey Temporal Cortex 査読

    Masaki Takeda, Kenji W. Koyano, Toshiyuki Hirabayashi, Yusuke Adachi, Yasushi Miyashita

    NEURON   86 ( 3 )   840 - 852   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CELL PRESS  

    Memory retrieval in primates is orchestrated by a brain-wide neuronal circuit. To elucidate the operation of this circuit, it is imperative to comprehend neuronal mechanisms of coordination between area-to-area interaction and information processing within individual areas. By simultaneous recording from area 36 (A36) and area TE (TE) of the temporal cortex while monkeys performed a pair-association memory task, we found two distinct inter-area signal flows during memory retrieval: A36 spiking activity exhibited coherence with low-frequency field activity in either the supragranular or infragranular layer of TE. Of these two flows, only signal flow targeting the infragranular layer of TE was further translaminarly coupled with gamma activity in the supragranular layer of TE. Moreover, this coupling was observed when monkeys succeeded in the retrieval of the sought object but not when they failed. The results suggest that local translaminar processing can be recruited via a layer-specific inter-area network for memory retrieval.

    DOI: 10.1016/j.neuron.2015.03.047

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  • Remapping of memory encoding and retrieval networks: Insights from neuroimaging in primates 査読

    Kentaro Miyamoto, Takahiro Osada, Yusuke Adachi

    BEHAVIOURAL BRAIN RESEARCH   275   53 - 61   2014年12月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    Advancements in neuroimaging techniques have allowed for the investigation of the neural correlates of memory functions in the whole human brain. Thus, the involvement of various cortical regions, including the medial temporal lobe (MTL) and posterior parietal cortex (PPC), has been repeatedly reported in the human memory processes of encoding and retrieval. However, the functional roles of these sites could be more fully characterized utilizing nonhuman primate models, which afford the potential for well-controlled, finer-scale experimental procedures that are inapplicable to humans, including electrophysiology, histology, genetics, and lesion approaches. Yet, the presence and localization of the functional counterparts of these human memory-related sites in the macaque monkey MTL or PPC were previously unknown. Therefore, to bridge the inter-species gap, experiments were required in monkeys using functional magnetic resonance imaging (fMRI), the same methodology adopted in human studies. Here, we briefly review the history of experimentation on memory systems using a nonhuman primate model and our recent fMRI studies examining memory processing in monkeys performing recognition memory tasks. We will discuss the memory systems common to monkeys and humans and future directions of finer cell-level characterization of memory-related processes using electrophysiological recording and genetic manipulation approaches. (C) 2014 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.bbr.2014.08.046

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  • Dissociable Memory Traces within the Macaque Medial Temporal Lobe Predict Subsequent Recognition Performance 査読

    Kentaro Miyamoto, Yusuke Adachi, Takahiro Osada, Takamitsu Watanabe, Hiroko M. Kimura, Rieko Setsuie, Yasushi Miyashita

    JOURNAL OF NEUROSCIENCE   34 ( 5 )   1988 - 1997   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SOC NEUROSCIENCE  

    Functional magnetic resonance imaging (fMRI) studies have revealed that activity in the medial temporal lobe (MTL) predicts subsequent memory performance in humans. Because of limited knowledge on cytoarchitecture and axonal projections of the human MTL, precise localization and characterization of the areas that can predict subsequent memory performance are benefited by the use of nonhuman primates in which integrated approach of the MRI- and cytoarchiture-based boundary delineation is available. However, neural correlates of this subsequent memory effect have not yet been identified in monkeys. Here, we used fMRI to examine activity in the MTL during memory encoding of events that monkeys later remembered or forgot. Application of both multivoxel pattern analysis and conventional univariate analysis to high-resolution fMRI data allowed us to identify memory traces within the caudal entorhinal cortex (cERC) and perirhinal cortex (PRC), as well as within the hippocampus proper. Furthermore, activity in the cERC and the hippocampus, which are directly connected, was responsible for encoding the initial items of sequentially presented pictures, which may reflect recollection-like recognition, whereas activity in the PRC was not. These results suggest that two qualitatively distinct encoding processes work in the monkey MTL and that recollection-based memory is formed by the interplay of the hippocampus with the cERC, a focal cortical area anatomically closer to the hippocampus and hierarchically higher than previously believed. These findings will advance the understanding of common memory system between humans and monkeys and accelerate fine electrophysiological characterization of these dissociable memory traces in the monkey MTL.

    DOI: 10.1523/JNEUROSCI.4048-13.2014

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  • A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques 査読

    Shimpei Iwaki, Kazuya Hokamura, Mikako Ogawa, Yasuo Takehara, Yasuaki Muramatsu, Takehiro Yamane, Kazuhisa Hirabayashi, Yuji Morimoto, Kohsuke Hagisawa, Kazuhide Nakahara, Tomoko Mineno, Takuya Terai, Toru Komatsu, Tasuku Ueno, Keita Tamura, Yusuke Adachi, Yasunobu Hirata, Makoto Arita, Hiroyuki Arai, Kazuo Umemura, Tetsuo Nagano, Kenjiro Hanaoka

    ORGANIC & BIOMOLECULAR CHEMISTRY   12 ( 43 )   8611 - 8618   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ROYAL SOC CHEMISTRY  

    Gadolinium(III) ion (Gd3+) complexes are widely used as contrast agents in magnetic resonance imaging (MRI), and many attempts have been made to couple them to sensor moieties in order to visualize biological phenomena of interest inside the body. However, the low sensitivity of MRI has made it difficult to develop practical MRI contrast agents for in vivo imaging. We hypothesized that practical MRI contrast agents could be designed by targeting a specific biological environment, rather than a specific protein such as a receptor. To test this idea, we designed and synthesized a Gd3+-based MRI contrast agent, 2BDP3Gd, for visualizing atherosclerotic plaques by linking the Gd3+-complex to the lipophilic fluorophore BODIPY to stain lipid-rich environments. We found that 2BDP3Gd was selectively accumulated into lipid droplets of adipocytes at the cellular level. Atherosclerotic plaques in the aorta of Watanabe heritable hyperlipidemic (WHHL) rabbits were clearly visualized in T-1-weighted MR images after intravenous injection of 2BDP3Gd in vivo.

    DOI: 10.1039/c4ob01270d

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  • Functional Differentiation of Memory Retrieval Network in Macaque Posterior Parietal Cortex 査読

    Kentaro Miyamoto, Takahiro Osada, Yusuke Adachi, Teppei Matsui, Hiroko M. Kimura, Yasushi Miyashita

    NEURON   77 ( 4 )   787 - 799   2013年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CELL PRESS  

    Human fMRI studies revealed involvement of the posterior parietal cortex (PPC) during memory retrieval. However, corresponding memory-related regions in macaque PPC have not been established. In this monkey fMRI study, comparisons of cortical activity during correct recognition of previously seen items and rejection of unseen items revealed two major PPC activation sites that were differentially characterized by a serial probe recognition paradigm: area PG/PGOp in inferior parietal lobule, along with the hippocampus, was more active for initial item retrieval, while area PEa/DIP in intraparietal sulcus was for the last item. Effective connectivity analyses revealed that connectivity from hippocampus to PG/PGOp, but not to PEa/DIP, increased during initial item retrieval. The two parietal areas with differential serial probe recognition profiles were embedded in two different subnetworks of the brain-wide retrieval-related regions. These functional dissociations in the macaque PPC imply the functional correspondence of retrieval-related PPC networks in macaques and humans.

    DOI: 10.1016/j.neuron.2012.12.019

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  • fMRI Activity in the Macaque Cerebellum Evoked by Intracortical Microstimulation of the Primary Somatosensory Cortex: Evidence for Polysynaptic Propagation 査読

    Teppei Matsui, Kenji W. Koyano, Keita Tamura, Takahiro Osada, Yusuke Adachi, Kentaro Miyamoto, Junichi Chikazoe, Tsukasa Kamigaki, Yasushi Miyashita

    PLOS ONE   7 ( 10 )   2012年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Simultaneous electrical microstimulation (EM) and functional magnetic resonance imaging (fMRI) is a useful tool for probing connectivity across brain areas in vivo. However, it is not clear whether intracortical EM can evoke blood-oxygenation-level-dependent (BOLD) signal in areas connected polysynaptically to the stimulated site. To test for the presence of the BOLD activity evoked by polysynaptic propagation of the EM signal, we conducted simultaneous fMRI and EM in the primary somatosensory cortex (S1) of macaque monkeys. We in fact observed BOLD activations in the contralateral cerebellum which is connected to the stimulation site (i.e. S1) only through polysynaptic pathways. Furthermore, the magnitude of cerebellar activations was dependent on the current amplitude of the EM, confirming the EM is the cause of the cerebellar activations. These results suggest the importance of considering polysynaptic signal propagation, particularly via pathways including subcortical structures, for correctly interpreting 'functional connectivity' as assessed by simultaneous EM and fMRI.

    DOI: 10.1371/journal.pone.0047515

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  • Functional Connectivity between Anatomically Unconnected Areas Is Shaped by Collective Network-Level Effects in the Macaque Cortex 査読

    Yusuke Adachi, Takahiro Osada, Olaf Sporns, Takamitsu Watanabe, Teppei Matsui, Kentaro Miyamoto, Yasushi Miyashita

    CEREBRAL CORTEX   22 ( 7 )   1586 - 1592   2012年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS INC  

    Coherent spontaneous blood oxygen level-dependent (BOLD) fluctuations have been intensely investigated as a measure of functional connectivity (FC) in the primate neocortex. BOLD-FC is commonly assumed to be constrained by the underlying anatomical connectivity (AC); however, cortical area pairs with no direct AC can also have strong BOLD-FC. On the mechanism generating FC in the absence of direct AC, there are 2 possibilities: 1) FC is determined by signal flows via short connection patterns, such as serial relays and common afferents mediated by a third area; 2) FC is shaped by collective effects governed by network properties of the cortex. In this study, we conducted functional magnetic resonance imaging in anesthetized macaque monkeys and found that BOLD-FC between unconnected areas depends less on serial relays through a third area than on common afferents and, unexpectedly, common efferents, which does not match the first possibility. By utilizing a computational model for interareal BOLD-FC network, we show that the empirically detected AC-FC relationships reflect the configuration of network building blocks (motifs) in the cortical anatomical network, which supports the second possibility. Our findings indicate that FC is not determined solely by interareal short connection patterns but instead is substantially influenced by the network-level cortical architecture.

    DOI: 10.1093/cercor/bhr234

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  • Method for Enhancing Cell Penetration of Gd3+-based MRI Contrast Agents by Conjugation with Hydrophobic Fluorescent Dyes 査読

    Takehiro Yamane, Kenjiro Hanaoka, Yasuaki Muramatsu, Keita Tamura, Yusuke Adachi, Yasushi Miyashita, Yasunobu Hirata, Tetsuo Nagano

    BIOCONJUGATE CHEMISTRY   22 ( 11 )   2227 - 2236   2011年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER CHEMICAL SOC  

    Gadolinium ion (Gd3+) complexes are commonly used as magnetic resonance imaging (MRI) contrast agents to enhance signals in T-1-weighted MR images. Recently, several methods to achieve cell-permeation of Gd3+ complexes have been reported, but more general and efficient methodology is needed. In this report, we describe a novel method to achieve cell permeation of Gd3+ complexes by using hydrophobic fluorescent dyes as a cell-permeability-enhancing unit. We synthesized Gd3+ complexes conjugated with boron dipyrromethene (BDP-Gd) and Cy7 dye (Cy7-Gd), and showed that these conjugates can be introduced efficiently into cells. To examine the relationship between cell permeability and dye structure, we further synthesized a series of Cy7-Gd derivatives. On the basis of MR imaging, flow cytometry, and ICP-MS analysis of cells loaded with Cy7-Gd derivatives, highly hydrophobic and nonanionic dyes were effective for enhancing cell permeation of Gd3+ complexes. Furthermore, the behavior of these Cy7-Gd derivatives was examined in mice. Thus, conjugation of hydrophobic fluorescent dyes appears to be an effective approach to improve the cell permeability of Gd3+ complexes, and should be applicable for further development of Gd3+-based MRI contrast agents.

    DOI: 10.1021/bc200127t

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  • Direct Comparison of Spontaneous Functional Connectivity and Effective Connectivity Measured by Intracortical Microstimulation: An fMRI Study in Macaque Monkeys 査読

    Teppei Matsui, Keita Tamura, Kenji W. Koyano, Daigo Takeuchi, Yusuke Adachi, Takahiro Osada, Yasushi Miyashita

    CEREBRAL CORTEX   21 ( 10 )   2348 - 2356   2011年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS INC  

    Correlated spontaneous activity in the resting brain is increasingly recognized as a useful index for inferring underlying functional-anatomic architecture. However, despite efforts for comparison with anatomical connectivity, neuronal origin of intrinsic functional connectivity (inFC) remains unclear. Conceptually, the source of inFC could be decomposed into causal components that reflect the efficacy of synaptic interactions and other components mediated by collective network dynamics (e.g., synchronization). To dissociate these components, it is useful to introduce another connectivity measure such as effective connectivity, which is a quantitative measure of causal interactions. Here, we present a direct comparison of inFC against emEC (effective connectivity probed with electrical microstimulation [EM]) in the somatosensory system of macaque monkeys. Simultaneous EM and functional magnetic resonance imaging revealed strong emEC in several brain regions in a manner consistent with the anatomy of somatosensory system. Direct comparison of inFC and emEC revealed colocalization and overall positive correlation within the stimulated hemisphere. Interestingly, we found characteristic differences between inFC and emEC in their interhemispheric patterns. Our results suggest that intrahemispheric inFC reflects the efficacy of causal interactions, whereas interhemispheric inFC may arise from interactions akin to network-level synchronization that is not captured by emEC.

    DOI: 10.1093/cercor/bhr019

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  • Intrasulcal ECoG approach to cortico-cortical connectivity using electrical stimulation-induced evoked potentials in macaques 査読

    Takahiro Osada, Antoine J. Molcard, Takeshi Matsuo, Keisuke Kawasaki, Yusuke Adachi, Kentaro Miyamoto, Tomomi Watanabe, Isao Hasegawa, Yasushi Miyashita

    NEUROSCIENCE RESEARCH   71   E97 - E97   2011年

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.neures.2011.07.415

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  • Role of directionality of axonal projections in shaping functional connectivity between macaque cortical areas 査読

    Yusuke Adachi, Takahiro Osada, Olaf Sporns, Takamitsu Watanabe, Teppei Matsui, Kentaro Miyamoto, Tomomi Watanabe, Yasushi Miyashita

    NEUROSCIENCE RESEARCH   71   E57 - E58   2011年

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.neures.2011.07.243

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  • Polysynaptic neuronal connectivity of S1 cortex revealed by simultaneous electrical microstimulation and fMRI in anesthetized macaque monkeys 査読

    Teppei Matsui, Keita Tamura, Kenji Koyano, Daigo Takeuchi, Tomomi Watanabe, Yusuke Adachi, Takahiro Osada, Yasushi Miyashita

    JOURNAL OF PHYSIOLOGICAL SCIENCES   60   S90 - S90   2010年

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    記述言語:英語   出版者・発行元:SPRINGER TOKYO  

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  • Towards understanding of the cortical network underlying associative memory 査読

    Takahiro Osada, Yusuke Adachi, Hiroko M. Kimura, Yasushi Miyashita

    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES   363 ( 1500 )   2187 - 2199   2008年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ROYAL SOC  

    Declarative knowledge and experiences are represented in the association cortex and are recalled by reactivation of the neural representation. Electrophysiological experiments have revealed that associations between semantically linked visual objects are formed in neural representations in the temporal and limbic cortices. Memory traces are created by the reorganization of neural circuits. These regions are reactivated during retrieval and contribute to the contents of a memory. Two different types of retrieval signals are suggested as follows: automatic and active. One flows backward from the medial temporal lobe during the automatic retrieval process, whereas the other is conveyed as a top-down signal from the prefrontal cortex to the temporal cortex during the active retrieval process. By sending the top-down signal, the prefrontal cortex manipulates and organizes to-be-remembered information, devises strategies for retrieval and monitors the outcome. To further understand the neural mechanism of memory, the following two complementary views are needed: how the multiple cortical areas in the brain-wide network interact to orchestrate cognitive functions and how the properties of single neurons and their synaptic connections with neighbouring neurons combine to form local circuits and to exhibit the function of each cortical area. We will discuss some new methodological innovations that tackle these challenges.

    DOI: 10.1098/rstb.2008.2271

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  • Exploring the neural basis of cognition: multi-modal links between human fMRl and macaque neurophysiology 査読

    Kiyoshi Nakahara, Yusuke Adachi, Takahiro Osada, Yasushi Miyashita

    TRENDS IN COGNITIVE SCIENCES   11 ( 2 )   84 - 92   2007年2月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE LONDON  

    Although functional magnetic resonance imaging (fMRI) with sophisticated behavioral paradigms has enabled the investigation of increasingly higher-level cognitive functions in humans, these studies seem to lose touch with neurophysiological studies in macaque monkeys. The application of fMRI and other MRI-based techniques to macaque brains allows studies in the two species to be linked. fMRI in human and macaque subjects using equivalent cognitive tasks enables direct comparisons of the functional brain architecture, even for high-level cognitive functions. Combinations of functional or structural MRI and microelectrode techniques provide ways to explore functional brain networks at multiple spatiotemporal scales. These approaches would illuminate the neurophysiological underpinnings of human cognitive functions by integrating human functional neuroimaging with macaque single-unit recordings.

    DOI: 10.1016/j.tics.2006.11.006

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  • Functional magnetic resonance imaging of macaque monkeys performing visually guided saccade tasks: Comparison of cortical eye fields with humans 査読

    M Koyama, Hasegawa, I, T Osada, Y Adachi, K Nakahara, Y Miyashita

    NEURON   41 ( 5 )   795 - 807   2004年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CELL PRESS  

    The frontal and parietal eye fields serve as functional landmarks of the primate brain, although their correspondences between humans and macaque monkeys remain unclear. We conducted fMRI at 4.7 T in monkeys performing visually-guided saccade tasks and compared brain activations with those in humans using identical paradigms. Among multiple parietal activations, the dorsal lateral intraparietal area in monkeys and an area in the posterior superior parietal lobule in humans exhibited the highest selectivity to saccade directions. In the frontal cortex, the selectivity was highest at the junction of the precentral and superior frontal sulci in humans and in the frontal eye field (FEF) in monkeys. BOLD activation peaks were also found in premotor areas (BA6) in monkeys, which suggests that the apparent discrepancy in location between putative human FEF (BA6, suggested by imaging studies) and monkey FEF (BA8, identified by microstimulation studies) partly arose from methodological differences.

    DOI: 10.1016/S0896-6273(04)00047-9

    Web of Science

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MISC

  • Similarities and differences of functional connectivity as measured by spontaneous correlation of fMRI signals and effective connectivity as measured by simultaneous intracortical microstimulation and fMRI

    Teppei Matsui, Kenji W. Koyano, Keita Tamura, Tomomi Watanabe, Daigo Takeuchi, Yusuke Adachi, Takahiro Osada, Yasushi Miyashita

    NEUROSCIENCE RESEARCH   71   E88 - E88   2011年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.neures.2011.07.377

    Web of Science

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共同研究・競争的資金等の研究

  • 相互作用する自己や他者への原因帰属を司る霊長類大脳の大域局所階層的機構の解明

    研究課題/領域番号:22K07323  2022年4月 - 2025年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    足立 雄哉

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

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  • サルの脳はどこまでヒトの脳の縮図か―誤信念と文字の認知を担う脳回路の機能と可塑性

    研究課題/領域番号:19H01038  2019年4月 - 2023年3月

    日本学術振興会  科学研究費助成事業 基盤研究(A)  基盤研究(A)

    長谷川 功, 飯島 淳彦, 松尾 健, 足立 雄哉, 鈴木 隆文, 中原 潔, 南本 敬史

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    配分額:45370000円 ( 直接経費:34900000円 、 間接経費:10470000円 )

    (1)心の理論検証の決め手となる誤信念認知の責任脳回路同定、(2)心の理論を操る駆け引きに関わる脳回路の種間相同性検証、(3)文字/文字様記号の認知を担う脳回路の種間相同性検証、という3つの下位目標を立て、項目ごとにマカクザルとヒトを対象とした実験を並行して進めた。
    (1)では、予期的眼球運動パラダイムの導入により、健常なマカクザルの自発眼球運動が他者の誤った信念にもとづく行動を予期する方向に偏り、誤信念の認知がサルにも可能であること、さらにDREADDsによる内側前頭前野の不活性化によりこの偏りがなくなることを示す知見を得た。得られた結果を学会発表(Akikawa et al Neuro2019; Akikawa et al SFN 2019)および論文発表(Hayashi et al Cell Reports 2020)した。
    (2)では、相手の正直度と利害関係に依存して正しい合図と嘘の合図を使い分けながら 駆け引きをさせる独自の社会認知課題を開発し、ヒトを対象とした行動実験・fMRIと、2頭のマカクザルを対象とした行動実験を開始した。
    (3)では、同じ要素が組合せ次第で異なる意味を表すような二要素記号を用意し、9種類のイラストの内容を主語様、動詞様、目的語様の3つのクラスの二要素記号の組み合わせとして表す課題を開発し、1頭のマカクザルがこの課題を学習できることを見出した。またヒトを対象として、連続提示した文字列を文節や文に連結させながら自分のペースで読ませる課題を開発して行動実験とfMRIをおこない、未連結の文字数・文節数に依存的に増減する左下前頭皮質の賦活を明らかにし、学会発表した(Kasedo et al Neuro2019)。

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  • 霊長類大脳皮質ネットワーク機能不全による自己への原因帰属の障害:化学遺伝学的研究

    研究課題/領域番号:19K07800  2019年 - 2023年

    日本学術振興会  科研費 基盤研究(C)  基盤研究(C)

    足立 雄哉

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    担当区分:研究代表者  資金種別:競争的資金

    本研究は、社会的な状況において自己や他者と事象の因果関係の認識を担う霊長類大脳皮質ネットワーク経路を調べることを目的とする。
    精緻な神経生理学研究や人為的な干渉を加える研究を行うために侵襲性を伴う実験手法を用いるには、動物における行動実験が必要である。本年度は、これまでに構築してきた、2頭のマカクザルが同時に参加する社会的な状況下での原因帰属課題を用いて行動実験を継続した。マカクザルは、自己・同種他個体・その他の実体の関わる出来事の原因構造を、自身による原因判断の経験を通して理解することができるだけでなく、他者が原因帰属をくりかえして原因構造をよく理解していく過程を観察することによっても理解し、そのあとに自分でもその原因構造に即して出来事の原因判断をすることができることを示唆する結果が得られている。さらに、出来事の原因構造がサルにとっていまだ不明確な状態での原因帰属行動を検証する実験を行った。サルは自身の原因判断の試行錯誤を通してだけでなく、類似した出来事の他者による少数回の原因判断行動の観察をもとに、因果関係が不明確な出来事の原因帰属行動を行うことができることを示唆する結果を得た。他者による自己あるいは他者への原因帰属と、自身による自己あるいは他者への原因帰属との相互作用の詳細を調べる行動実験が継続中であり、開発中の皮質脳波電極を用いた電気生理学的な神経活動記録による脳領野ネットワーク同定実験を進行する。

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  • 大脳皮質大域的ネット ワークの時空構造操作による自己-外界間因果の主観的判断の改変

    2016年 - 2018年

    日本学術振興会  科研費 若手研究(B) 

    足立 雄哉

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    担当区分:研究代表者  資金種別:競争的資金

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  • 急速眼球運動における サル大脳半球間競合を担う神経経路の同定:光遺伝学的 fMRI

    2013年 - 2015年

    日本学術振興会  科研費 若手研究(B) 

    足立 雄哉

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    担当区分:研究代表者  資金種別:競争的資金

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  • fMRI による 大脳領野間有効結合推定法の実験的検証 : 局所的皮質不活性化による研究

    2004年 - 2006年

    日本学術振興会  特別研究員奨励費(DC1) 

    足立 雄哉

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    担当区分:研究代表者  資金種別:競争的資金

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