Updated on 2024/04/25

写真a

 
MISHIMA Takehito
 
Organization
University Medical and Dental Hospital Operation Center Associate Professor
Title
Associate Professor
Other name(s)
Takehito Mishima
External link

Degree

  • 博士（医学） ( 2008.3   新潟大学 )

Research Areas

  • Life Science / Cardiovascular surgery  / 心臓血管外科学

Research History (researchmap)

  • Niigata University   Associate Professor

    2023.9

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  • 新潟大学医歯学総合病院   特任講師

    2021.4 - 2023.9

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  • Niigata University   University Medical and Dental Hospital Operation Center   Assistant Professor

    2018.7 - 2021.3

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  • Niigata University   University Medical and Dental Hospital Cardiovascular Surgery   Specially Appointed Assistant Professor

    2018.4 - 2018.6

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  • Niigata University   University Medical and Dental Hospital Uonuma Institute of Community Medicine   Specially Appointed Lecturer

    2015.4 - 2016.3

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Research History

  • Niigata University   Operation Center, University Medical and Dental Hospital   Associate Professor

    2023.9

  • Niigata University   Operation Center, University Medical and Dental Hospital   Specially Appointed Lecturer

    2021.4 - 2023.8

  • Niigata University   University Medical and Dental Hospital Operation Center   Assistant Professor

    2018.7 - 2021.3

  • Niigata University   University Medical and Dental Hospital Cardiovascular Surgery   Specially Appointed Assistant Professor

    2018.4 - 2018.6

  • Niigata University   University Medical and Dental Hospital UONUMA CHIIKI IRYO KYOIKU CENTER JUNBISHITU   Specially Appointed Lecturer

    2015.4 - 2016.3

Education

  • Niigata University   Graduate School, Division of Medical Sciences   生体機能調節医学

    2004.4 - 2008.3

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    Country： Japan

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  • Niigata University   Faculty of Medicine   department of medicine

    1995.4 - 2001.3

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    Country： Japan

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Papers

  • Blood flow analysis with computational fluid dynamics in the left atrium after left atrial plication: a prospective study.

    Takashi Enomoto, Takehito Mishima, Masanori Tsuchida

    General thoracic and cardiovascular surgery   2023.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: This study aimed to evaluate blood flow stagnation in an enlarged left atrium (LA) and prove that left atrial plication (LAP) could alleviate the stagnation. METHODS: Five patients with chronic atrial fibrillation who underwent mitral valve surgery followed by LAP for an enlarged LA with a ≥ 60-mm diameter were included. We performed computational fluid dynamics (CFD) analysis using preoperative and postoperative computed tomography and four-dimensional flow magnetic resonance imaging. Additionally, computer graphics were used to create virtual left atrial appendage resection (LAAR) images. We performed CFD analysis to assess blood flow stagnation in the LA for three groups: preoperative, LAAR, and LAP. RESULTS: When the average and constant stagnation volumes were both set to 100 preoperatively, the average stagnation volumes of the LAAR and LAP groups were 67.42 ± 18.64 and 35.88 ± 8.20, respectively. The constant stagnation volumes of these groups reduced to 45.01 ± 7.43 and 21.14 ± 7.70, respectively. The LAP group also had significantly lower average and constant stagnation volumes than those in the LAAR group (p = 0.006 and p = 0.033, respectively). CONCLUSIONS: Blood flow stagnation was noted in the LAA and enlarged LA. CFD analysis revealed that LAP for the enlarged LA improved blood flow stagnation more than the virtual LAAR alone. CLINICAL TRIAL REGISTRY NUMBER: UMIN000049923.

    DOI： 10.1007/s11748-023-01963-2

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  • Platypnea-orthodeoxia Syndrome Due to Right Ventricular Inflow Tract Obstruction Caused by an Elongated Ascending Aorta: Usefulness of Three-dimensional Cardiac Computed Tomography Imaging in the Sitting Position.

    Yuki Hasegawa, Daisuke Izumi, Yasuhiro Ikami, Takeshi Okubo, Makoto Hoyano, Kazuyuki Ozaki, Noriaki Sato, Takehito Mishima, Takayuki Inomata

    Internal medicine (Tokyo, Japan)   61 ( 15 )   2315 - 2317   2022.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    An 84-year-old woman presented with dyspnea in the sitting position. Platypnea-orthodeoxia syndrome (POS) was suspected based on arterial desaturation when her posture changed from the supine to the sitting position. Transesophageal echocardiography showed right-to-left shunting enhancement through a patent foramen ovale (PFO) in the sitting position. Three-dimensional (3D) cardiac CT in the sitting position revealed that the elongated ascending aorta compressed the right ventricular inflow tract, resulting in restricted blood flow to the right ventricle and increased right-to-left shunting. This case highlights the role of 3D-CT in the sitting position in the management of POS.

    DOI： 10.2169/internalmedicine.8868-21

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  • Acute aortic thrombosis in the ascending aorta after cisplatin-based chemotherapy for esophageal cancer: a case report. International journal

    Noriaki Sato, Takehito Mishima, Yuka Okubo, Takeshi Okamoto, Shuichi Shiraishi, Masanori Tsuchida

    Surgical case reports   8 ( 1 )   75 - 75   2022.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: The risk of thrombus development is considered to be increased by malignant tumors and chemotherapy. In addition, thrombosis of the ascending aorta is rare. We report a case of ascending aortic thrombectomy in a patient with esophageal cancer who developed ascending aortic thrombus after starting neoadjuvant chemotherapy, including operative findings and surgical treatment. CASE PRESENTATION: A 63-year-old man with esophageal cancer was administered chemotherapy comprising cisplatin plus 5-fluorouracil. A week after completing 1 cycle of chemotherapy, computed tomography angiography showed acute aortic thrombosis at the ascending aorta. The risk of embolization appeared high because the thrombosis was floating, so we performed emergency ascending aortic thrombectomy. The postoperative course was good and uncomplicated. A month after this surgery, the patient underwent surgery for esophageal cancer. As of 1 year after the cancer surgery, neither cancer nor thrombosis has recurred. CONCLUSION: We describe a case of acute aortic thrombosis in the ascending aorta after cisplatin-based chemotherapy, that was treated by aortic thrombectomy. The treatment strategy should depend on thrombus location and the condition of the patient, but surgical treatment should be considered where possible to achieve better prognosis.

    DOI： 10.1186/s40792-022-01431-8

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  • Ensure an "Ultrasound Window" on the Patient's Neck to Evaluate Cerebral Blood Flow! International journal

    Tomohiro Yamamoto, Takehito Mishima, Shuichi Shiraishi, Takeshi Saito, Ehrenfried Schindler

    The Thoracic and cardiovascular surgeon   70 ( 1 )   50 - 55   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Near-infrared spectroscopy (NIRS) does not provide information about changes in oxygenation in whole-brain areas. Although the branching vessels of the aortic arch are not always easy to identify using transesophageal echocardiography (TEE), the blood flow status of cervical arteries can always be assessed by applying an ultrasound probe via the "ultrasound window" on the patient's neck, which can be ensured by devising alternative insertion approaches of the central venous catheter. This method is very simple but compensates for the limitations of the combination of NIRS and TEE, especially during cardiac surgery with cardiopulmonary bypass management using selective cerebral perfusion.

    DOI： 10.1055/s-0041-1725181

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  • A case of tricuspid valvuloplasty for symptomatic tricuspid regurgitation due to ventricular pacing lead Reviewed

    Mishima Takehito, Goto Tatsuya, Shimada Koji, Ohzeki Hajime

    Shinzo   46 ( 6 )   742 - 746   2014.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Heart Foundation  

    DOI： 10.11281/shinzo.46.742

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    Other Link： http://search.jamas.or.jp/link/ui/2014260953

  • Severe aortic regurgitation resulting from a downward displacement of anterior aortic annulus and fibrous strands in the bicuspid aortic valve. Reviewed

    三島健人

    Annals of thoracic and cardiovascular surgery   16 ( 1 )   57 - 59   2010

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Annals of thoracic and cardiovascular surgery  

    Aortic regurgitation is occasionally caused by fibrous strands and more rarely by downward displacement of the aortic annulus. The present report describes an 18-year-old man with aortic regurgitation resulting from an anterior-posterior type of bicuspid aortic valve with fibrous strands and downward displacement of the anterior aortic annulus. A pair of fibrous strands at the anterior cusp of the bicuspid valve lifted the free margin of the cusp, and the anterior cusp originated from the intraventricular septum. We considered that the aortic regurgitation was due to poor coaptation of the cusps because of these two conditions. After resection of the cusps and the strands, the aortic valve was replaced at the intra-annular position.

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  • A case of traumatic tricuspid regurgitation without chordal or papillary muscle rupture Reviewed

    Mishima Takehito, Yamamoto Kazuo, Sato Masahiro, Uehara Akifumi, Takizawa Kohki, Sugimoto Tsutomu, Yoshii Shinpei, Kasuya Shigetaka

    Shinzo   41 ( 11 )   1276 - 1279   2009.11

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Heart Foundation  

    DOI： 10.11281/shinzo.41.1276

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    Other Link： http://search.jamas.or.jp/link/ui/2010039474

  • 上行大動脈に仮性瘤を伴った大動脈弁位感染性心内膜炎の1例 Reviewed

    三島健人

    日本心臓血管外科学会雑誌   38 ( 4 )   293 - 296   2009.4

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本心臓血管外科学会  

    症例は62歳男性．感染性心内膜炎を発症．抗菌剤で感染徴候は改善したが大動脈弁および僧帽弁での重度の逆流を認め手術適応となった．術前CT検査で無冠尖直上の大動脈後壁に径約20 mm大の仮性瘤を認め，感染性心内膜炎に合併した上行大動脈仮性瘤の診断で手術を行った．大動脈弁は無冠尖弁尖に感染を認めたが，弁輪には明らかな変化を認めなかった．瘤は大動脈内壁が陥没したような形状で，同部の外側面には血液の浸出を認めたが，無冠尖弁尖と動脈瘤間の大動脈壁には感染の連続性はなかった．Composite graftを用いたベントール手術および僧帽弁形成術を行い，術後一過性に右冠動脈の閉塞を生じたものの概ね良好に経過した．病理組織検査では無冠尖に著明な炎症細胞浸潤があり，動脈瘤は内膜，中膜を欠いた仮性動脈瘤であった．感染性心内膜炎の診療に際しては，全身のあらゆる血管に動脈瘤形成の可能性があることを念頭におく必要があると考えられた．

    DOI： 10.4326/jjcvs.38.293

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  • プロスタグランディンE1製剤による血管平滑筋細胞培養系におけるVEGF-A splice variantの発現パターン変化(Real-time PCRを用いたラットVEGF-A splice variantの定量化) Reviewed

    三島 健人

    新潟医学会雑誌   122 ( 7 )   363 - 371   2008.3

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    Language：Japanese   Publishing type：Doctoral thesis  

    血管内皮細胞増殖因子(VEGF-A)は血管の再生において重要な役割をすることが示されているが, splicingによるいくつかのvariantの存在が知られている. また, アンタゴニストとして働くvariantの存在も最近示されている. しかし, これらを分離して検出する抗体が存在しないことから, 今回real-time PCRを用いた定量性のある検出系を開発した. 一方, 閉塞性動脈硬化症の治療にはプロスタグランディンE1製剤が頻用されるが, 血管拡張作用, 血小板凝集抑制作用は良く理解されているものの, 動脈硬化性病変の主役を演じる血管平滑筋細胞に対する影響は十分に知られていない. プロスタグランディンE1とリポ化プロスタグランディンE1製剤およびそのdrug delivery systemであるlipid microsphereの血管平滑筋細胞に対する効果を検討するために, 今回開発した機能性VEGF-AmRNA splice variant (VEGF-A120, VEGF-A164, VEGF-A188)および抑制性splice variant (VEGF-A164b)の定量法を用いた. ラット血管平滑筋細胞培養系において血清刺激とプロス

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  • A modified infarct exclusion technique: triple-patch technique for postinfarction ventricular septal perforation. International journal

    Tsutomu Sugimoto, Shinpei Yoshii, Kazuo Yamamoto, Kenji Sakakibara, Yasunori Iida, Akifumi Uehara, Takehito Mishima, Sigetaka Kasuya

    The Journal of thoracic and cardiovascular surgery   135 ( 3 )   702 - 3   2008.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jtcvs.2007.11.034

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