Updated on 2025/09/22

写真a

 
OKAMOTO Keiichiro
 
Organization
Academic Assembly Institute of Medicine and Dentistry SHIGAKU KEIRETU Associate Professor
Graduate School of Medical and Dental Sciences Oral Life Science Oral Biological Science Associate Professor
Title
Associate Professor
External link

The Best Research Achievement in Research Career

    • 【Papers】 Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice  2022

    • 【Papers】 Estrogen status and psychophysical stress modify temporomandibular joint input to medullary dorsal horn neurons in a lamina-specific manner in female rats  2013.7

    • 【Papers】 A novel class of neurons at the trigeminal subnucleus interpolaris/caudalis transition region monitors ocular surface fluid status and modulates tear production  2004.4

Degree

  • PhD ( 2006.2   Wakayama Medical University )

  • 歯学士 ( 1993.3   九州歯科大学 )

Research Interests

  • 脊髄

  • 報酬系

  • 青斑核

  • 酒粕

  • 日本酒

  • 慢性痛

  • 大縫線核

  • photophobia

  • 角膜痛

  • stress

  • descending pain controls

  • estrogen

  • Neuroscience

  • 嚥下

  • Pain

  • trigeminal subnucleus caudalis

  • orofacial pain

Research Areas

  • Life Science / Surgical dentistry  / pain

  • Life Science / Pathophysiologic neuroscience

  • Life Science / Oral biological science  / Pain Neuroscience Physiology

Research History (researchmap)

  • Niigata University   Graduate School of Medical and Dental Sciences   Associate Professor

    2015.8

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  • University of Minnesota School of Dentistry   Research Associate

    2006.8 - 2015.6

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  • Wakayama Medical University   Assistant Professor

    2004.4 - 2006.7

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  • Wakayama Medical University

    2004.1 - 2004.3

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  • Brown University, Medical School. RI Hospital   Research Associate

    2001.2 - 2003.12

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  • Wakayama Medical University

    1999.4 - 2001.1

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  • Wakayama Medical University

    1998.4 - 1999.3

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  • 橋本市民病院   歯科口腔外科 医員

    1996.10 - 1998.3

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  • Wakayama Medical University

    1995.10 - 1996.8

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  • 日本赤十字社和歌山医療センター   麻酔科   研修医

    1995.4 - 1995.9

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  • Wakayama Medical University

    1993.4 - 1995.3

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Research History

  • Niigata University   Graduate School of Medical and Dental Sciences Oral Life Science Oral Biological Science   Associate Professor

    2015.7

Education

  • 福岡県立九州歯科大学

    1987.4 - 1993.3

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  • 清風南海高校

    1984.4 - 1987.3

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Professional Memberships

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Committee Memberships

  • 日本口腔顔面痛学会   学術研究検討部会 委員  

    2024.1   

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    Committee type：Academic society

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  • 歯科薬物療法学会   評議員  

    2021.4   

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    Committee type：Academic society

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  • 日本口腔顔面痛学会   学術雑誌編集委員会・副委員長  

    2018.4   

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    Committee type：Academic society

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  • 日本生理学会   教育委員  

    2017.4 - 2020.3   

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    Committee type：Academic society

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Studying abroad experiences

  • Brown University Medical School   Research Associate

    2000.1 - 2003.12

Qualification acquired

  • Dentist

 

Papers

  • Daily Administration of Agmatine Reduced Anxiety-like Behaviors and Neural Responses in the Brains of Male Mice with Persistent Inflammation in the Craniofacial Region. Reviewed International journal

    Yuya Iwamoto, Kajita Piriyaprasath, Andi Sitti Hajrah Yusuf, Mana Hasegawa, Yoshito Kakihara, Tsutomu Sato, Noritaka Fujii, Kensuke Yamamura, Keiichiro Okamoto

    Nutrients   17 ( 11 )   1848 - 1848   2025.5

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Background/Objectives: Chronic craniofacial inflammation is recognized as a factor in anxiety-like behaviors, yet effective therapeutic options remain limited. Agmatine, a dietary bioactive compound found in fermented foods such as sake lees, exhibits modulatory effects on neural functions, alleviating psychological distress like anxiety associated with local inflammation. Methods: We investigated both the therapeutic and preventive effects of agmatine on anxiety-like behaviors and the related neural basis in a mouse model of persistent craniofacial inflammation induced by complete Freund’s adjuvant (CFA). Results: Comprehensive behavioral assessments, including the elevated plus maze, open field, dark–light box, social interaction, and novel object recognition tests, revealed that therapeutic agmatine administration (1.0 and 30 mg/kg) significantly reduced CFA-induced anxiety-like behaviors, with the higher dose showing more robust and sustained effects across multiple time points. These behavioral improvements were paralleled by reductions in acetylated histone H3, FosB, and c-Fos expression in key anxiety-related brain regions, suggesting a reversal of craniofacial inflammation-associated neural changes. In contrast, preventive agmatine treatment exerted modest and time-dependent behavioral benefits with minimal molecular normalization. Notably, preventive agmatine did not affect general locomotor activity (indicated by total movement distance), indicating that its anxiolytic effects were not confounded by altered locomotor activity. Metabolomic analysis confirmed the presence of agmatine in sake lees (~0.37 mM), supporting the hypothesis that fermented food products might offer dietary routes to emotional resilience. Conclusions: These findings underscore agmatine’s promise as a context-specific epigenetic modulator capable of mitigating anxiety-like behaviors by normalizing inflammation-driven molecular dysregulation in the brain.

    DOI： 10.3390/nu17111848

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  • Effects of potassium on laryngeal induced swallowing rate in rats Reviewed

    Satomi Kawada, Titi Chotirungsan, Charng-Rong Pan, Yuhei Tsutsui, Keiichiro Okamoto, Jin Magara, Takanori Tsujimura, Makoto Inoue

    American Journal of Physiology-Gastrointestinal and Liver Physiology   2025.4

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    Publishing type：Research paper (scientific journal)   Publisher：American Physiological Society  

    The swallowing reflex can be induced by peripheral stimulation of the larynx. Although previous studies have suggested that potassium ions exert facilitatory effects on the initiation of swallowing, little information is available on the mechanism underlying the potassium ion-evoked swallowing reflex. In this study, we evaluated the effects of potassium ions on peripheral afferent responses and the initiation of swallowing in conscious and anesthetized rats. Furthermore, the possible receptors involved were explored. The topical application of potassium chloride (KCl) significantly facilitated the swallowing reflex; these facilitatory effects were more prominent than those of distilled water (DW) or sodium chloride (NaCl). This phenomenon depended not on the concentrations of anions but on those of potassium ions. The potassium ion-induced response in the superior laryngeal nerve was most prominent after treatment with KCl, especially at the early stage. In chronic rats, without differences in licking behavior between DW, NaCl, and KCl, the intervals between swallows were the smallest during KCl-associated licking. Inward rectifier potassium channel (Kir)3.1- and Kir6.2-positive cells were detected in the nodose ganglion and vocal folds. The rate of expression of these molecules in immunoreactive cells was relatively high at 74.1% for Kir3.1 and 75.3% for Kir6.2. Kir3.1- and Kir6.2- blockers significantly decreased the number of KCl-induced swallows. Possible mechanisms underlying potassium ion-induced swallowing are discussed. Our findings suggest that Kir3.1 and Kir6.2 are involved in K ion-induced swallowing in rats.

    DOI： 10.1152/ajpgi.00012.2025

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  • The central neural control of the posterior belly of the digastric muscles during swallowing in rats Reviewed

    Yuhei Tsutsui, Titi Chotirungsan, Charng-Rong Pan, Satomi Kawada, Jin Magara, Takanori Tsujimura, Keiichiro Okamoto, Makoto Inoue

    American Journal of Physiology-Gastrointestinal and Liver Physiology   2025.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Physiological Society  

    The aim of this study was to clarify whether the posterior belly of the digastric (post-Dig) muscle is activated during the swallowing reflex and whether the post-Dig muscle is directly controlled by the swallowing central pattern generator (CPG) in anesthetized rats, using physiological and immunohistochemical approaches. In physiological study, electromyograms (EMGs) of the post-Dig, sternohyoid and thyrohyoid muscles, and the diaphragm were recorded during respiration and swallowing with and without airway stenosis. In the immunohistochemical study, c-Fos immunoreactivity for expression of cells during swallowing was analyzed. Motoneurons were identified using immunohistochemistry with Fluoro-gold (FG). EMG bursts were observed in the hyoid muscles during the inspiratory phase and swallowing. With airway stenosis, the swallowing EMG activity was facilitated in terms of duration and area only in the post-Dig muscle. The coordination of these EMG activities during swallowing was maintained with airway stenosis. In contrast, the offset of the post-Dig EMG burst was delayed with airway stenosis. c-Fos-positive cells were observed in the accessory facial nucleus (Acs7), but only in the rostral portion. FG-labeled cells were observed in Acs7. Several c-Fos/FG double-labeled cells were observed only in the rostral Acs7. These results suggested that the post-Dig muscle is activated during swallowing, the activation of which is controlled by the swallowing CPG, and that the distribution of Acs7 neurons, which innervate the post-Dig muscle, was uneven in the nucleus. In addition, the modulation of post-Dig muscle activity during inspiration might be due to changes in peripheral conditions via respiratory CPG.

    DOI： 10.1152/ajpgi.00374.2024

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  • Effects of treadmill running on anxiety- and craniofacial pain-like behaviors with histone H3 acetylation in the brain of mice subjected to social defeat stress Reviewed

    Kajita Piriyaprasath, Mana Hasegawa, Yuya Iwamoto, Rantaro Kamimura, Andi Sitti Hajrah Yusuf, Noritaka Fujii, Kensuke Yamamura, Keiichiro Okamoto

    PLOS ONE   20 ( 1 )   e0318292 - e0318292   2025.1

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Public Library of Science (PLoS)  

    This study examined the effects of treadmill running (TR) regimens on craniofacial pain- and anxiety-like behaviors, as well as their effects on neural changes in specific brain regions of male mice subjected to repeated social defeat stress (SDS) for 10 days. Behavioral and immunohistochemical experiments were conducted to evaluate the impact of TR regimens on SDS-related those behaviors, as well as epigenetic and neural activity markers in the anterior cingulate cortex (ACC), insular cortex (IC), rostral ventromedial medulla (RVM), and cervical spinal dorsal horn (C2). Behavioral responses were quantified using multiple tests, while immunohistochemistry measured histone H3 acetylation, histone deacetylases (HDAC1, HDAC2), and neural activity markers (FosB and phosphorylated cAMP response element-binding protein (pCREB). The effects of both short-term TR (2 days, TR2) and long-term TR (10 days, TR10) regimens were conducted. TR10 significantly reduced anxiety- and formalin-evoked craniofacial pain-like behaviors in SDS mice. It normalized SDS-induced increases in histone H3 acetylation in both the anterior and posterior portions of the ACC, as well as the anterior portion of the IC. These inhibitory effects were also observed in SDS-related increases in HDAC1, FosB, and pCREB expression. Additionally, TR10 normalized increased histone H3 acetylation in the RVM and C2 regions, with specific effects on FosB and pCREB expression observed in the C2 region. In contrast, TR2 showed limited effects on craniofacial pain-like behaviors but reduced anxiety-like behaviors in SDS mice. Under sham conditions, TR2 had minimal impact on histone H3 acetylation. Paradoxically, TR2 increased formalin-evoked craniofacial pain-like behaviors during the early phase despite not altering acetylated histone H3 expression. In conclusion, the TR10 regimen is effective in attenuating SDS-induced craniofacial pain- and anxiety-like behaviors, likely by normalizing epigenetic modifications and neural activity in key brain regions.

    DOI： 10.1371/journal.pone.0318292

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  • Nutritional Strategies for Chronic Craniofacial Pain and Temporomandibular Disorders: Current Clinical and Preclinical Insights Reviewed

    Kajita Piriyaprasath, Yoshito Kakihara, Mana Hasegawa, Yuya Iwamoto, Yoko Hasegawa, Noritaka Fujii, Kensuke Yamamura, Keiichiro Okamoto

    Nutrients   16 ( 17 )   2868   2024.8

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    This narrative review provides an overview of current knowledge on the impact of nutritional strategies on chronic craniofacial pain associated with temporomandibular disorders (TMDs). Individuals experiencing painful TMDs alter their dietary habits, avoiding certain foods, possibly due to chewing difficulties, which might lead to nutrient deficiencies. Our literature investigation revealed that the causal links between nutritional changes and craniofacial pain remain unclear. However, clinical and preclinical studies suggest that nutraceuticals, including vitamins, minerals, polyphenols, omega-3 fatty acids, isoprenoids, carotenoids, lectins, polysaccharides, glucosamines, and palmitoylethanolamides, could have beneficial effects on managing TMDs. This is described in 12 clinical and 38 preclinical articles since 2000. Clinical articles discussed the roles of vitamins, minerals, glucosamine, and palmitoylethanolamides. The other nutraceuticals were assessed solely in preclinical studies, using TMD models, mostly craniofacial inflammatory rodents, with 36 of the 38 articles published since 2013. Our investigation indicates that current evidence is insufficient to assess the efficacy of these nutraceuticals. However, the existing data suggest potential for therapeutic intervention in TMDs. Further support from longitudinal and randomized controlled studies and well-designed preclinical investigations is necessary to evaluate the efficacy of each nutraceutical intervention and understand their underlying mechanisms in TMDs.

    DOI： 10.3390/nu16172868

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  • Preventive roles of Rice-koji extracts and ergothioneine on anxiety- and pain-like responses under psychophysical stress conditions in male mice. Reviewed

    Kajita Piriyaprasath, Yoshito Kakihara, Atsushi Kurahashi, Mayumi Taiyoji, Kazuya Kodaira, Kotaro Aihara, Mana Hasegawa, Kensuke Yamamura, Keiichiro Okamoto

    Nutrients   15 ( 18 )   3989   2023.9

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  • Effects of stress contagion on anxiogenic- and orofacial inflammatory pain-like behaviors with brain activation in mice. Reviewed International journal

    Kajita Piriyaprasath, Mana Hasegawa, Yoshito Kakihara, Yuya Iwamoto, Rantaro Kamimura, Isao Saito, Noritaka Fujii, Kensuke Yamamura, Keiichiro Okamoto

    European Journal of Oral Sciences   e12942   2023.6

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    The conditions of stress contagion are induced in bystanders without direct experiences of stressful events. This study determined the effects of stress contagion on masseter muscle nociception in mice. Stress contagion was developed in the bystanders after cohabitating with a conspecific mouse subjected to social defeat stress for 10 days. On Day 11, stress contagion increased anxiety- and orofacial inflammatory pain-like behaviors. The c-Fos and FosB immunoreactivities evoked by masseter muscle stimulation were increased in the upper cervical spinal cord, while c-Fos expressions were increased in the rostral ventromedial medulla, including the lateral paragigantocellular reticular nucleus and nucleus raphe magnus in stress contagion mice. The level of serotonin in the rostral ventromedial medulla was increased under stress contagion, while the number of serotonin positive cells was increased in the lateral paragigantocellular reticular nucleus. Stress contagion increased c-Fos and FosB expressions in the anterior cingulate cortex and insular cortex, both of which were positively correlated with orofacial inflammatory pain-like behaviors. The level of brain-derived neurotrophic factor was increased in the insular cortex under stress contagion. These results indicate that stress contagion can cause neural changes in the brain, resulting in increased masseter muscle nociception, as seen in social defeat stress mice.

    DOI： 10.1111/eos.12942

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  • Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice Reviewed International journal

    Mana Hasegawa, Kajita Piriyaprasath, Masanori Otake, Rantaro Kamimura, Isao Saito, Noritaka Fujii, Kensuke Yamamura, Keiichiro Okamoto

    European Journal of Oral Sciences   130 ( 4 )   e12882   2022

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    We investigated the effects of social defeat stress (SDS) and treadmill running on masseter muscle nociception, which was quantified by the orofacial formalin test and c-Fos and FosB immunoreactivities in the upper cervical spinal cord (C1/C2) region in male mice. After daily SDS or non-SDS conditioning for 10 days, SDS-conditioned mice were categorized into SDS-susceptible versus resilient mice. Several mice, including non-SDS-conditioned, SDS-susceptible, and resilient mice, were selected to assess masseter muscle nociception on Day 11. SDS conditioning for 10 days increased masseter muscle-evoked nocifensive behaviors and c-Fos and FosB expression in SDS-susceptible compared to non-SDS and resilient mice. The remaining SDS-susceptible and non-SDS mice were subjected to an additional 10 days of SDS plus treadmill running or sedentary sessions before assessing masseter muscle nociception on Day 21. Daily treadmill running sessions reduced enhanced masseter muscle nociception in SDS-susceptible mice but not in non-SDS mice. The preventive effects of daily treadmill running immediately after each SDS conditioning for 10 days on orofacial nocifensive behaviors were assessed on Day 11. Treadmill running conducted immediately after daily SDS inhibited enhanced orofacial nocifensive behaviors. These findings indicate that repeated SDS increases masseter muscle nociception, which could be prevented by daily treadmill running exercise.

    DOI： 10.1111/eos.12882

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  • Preclinical models of deep craniofacial nociception and temporomandibular disorder pain Reviewed

    Keiichiro Okamoto, Mana Hasegawa, Kajita Piriyaprasath, Yoshito Kakihara, Makio Saeki, Kensuke Yamamura

    Japanese Dental Science Review   57   231 - 241   2021.11

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    Chronic pain in temporomandibular disorder (TMD) is a common health problem. Cumulating evidence indicates that the etiology of TMD pain is complex with multifactorial experience that could hamper the developments of treatments. Preclinical research is a resource to understand the mechanism for TMD pain, whereas limitations are present as a disease-specific model. It is difficult to incorporate multiple risk factors associated with the etiology that could increase pain responses into a single animal. This article introduces several rodent models which are often employed in the preclinical studies and discusses their validities for TMD pain after the elucidations of the neural mechanisms based on the clinical reports. First, rodent models were classified into two groups with or without inflammation in the deep craniofacial tissues. Next, the characteristics of each model and the procedures to identify deep craniofacial pain were discussed. Emphasis was directed on the findings of the effects of chronic psychological stress, a major risk factor for chronic pain, on the deep craniofacial nociception. Preclinical models have provided clinically relevant information, which could contribute to better understand the basis for TMD pain, while efforts are still required to bridge the gap between animal and human studies.

    DOI： 10.1016/j.jdsr.2021.10.002

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  • Effects of rice fermented extracts, "Sake Lees", on the functional activity of odontoblast-like cells (KN-3 cells). Reviewed

    Keiichiro Okamoto, Yoshito Kakihara, Naoto Ohkura, Aiko Tohma, Ayako Washio, Chiaki Kitamura, Yuichiro Noiri, Kensuke Yamamura, Makio Saeki

    Odontology   110 ( 2 )   254 - 261   2021.9

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    This study was designed to investigate the effects of Sake Lees extracts (SLE, Sake Kasu) on the functional activity of odontoblastic cells and tooth pulp of the rats. For in vitro studies, a rat clonal odontoblast-like cell line, KN-3 cells were cultured. SLE significantly decreased KN-3 cell proliferation, but showed no significant cytotoxicity. SLE effects on several protein productions of KN-3 cells were compared with PBS. SLE and PBS increased alkaline phosphatase (ALP), dentin sialoprotein (DSP), and osterix in a day-course dependent manner, while SLE increased the induction of ALP on day 9-21 and DSP on day 15-21. SLE also increased Runx2 expression on day 3 and 9 compared to PBS. Alizarin Red stainings revealed that SLE showed a subtle increase in mineralization of KN-3 cells on day 15 and 21. A histological investigation was conducted to assess if SLE induced reparative dentin formation after direct capping at the exposed tooth pulp in rats, suggesting that SLE could increase the reparative dentin formation more than PBS. These findings suggest that Sake Lees could have functional roles in the alterations of odontoblastic activity, which might influence the physiology of the tooth pulp.

    DOI： 10.1007/s10266-021-00654-9

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  • Modulatory effects of repeated psychophysical stress on masseter muscle nociception in the nucleus raphe magnus of rats. Reviewed

    Shiho Shimizu, Yosuke Nakatani, Masayuki Kurose, Hiroki Imbe, Nobuyuki Ikeda, Ritsuo Takagi, Kensuke Yamamura, Keiichiro Okamoto

    Journal of Oral Science   62 ( 2 )   231 - 235   2020.2

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Psychophysical stress can cause neural changes that increase nociception in the orofacial region, particularly the masseter muscle (MM). The nucleus raphe magnus (NRM), which is located in the brain stem, serves the crucial role of regulating nociception through descending modulatory pain control. However, it remains unclear if neural activities in the NRM are affected under psychophysical stress conditions. This study conducted experiments to assess (1) whether neural activity, indicated by Fos expression in an NRM that has experienced MM injury, is affected by the stress of repeated forced swim tests (FST); and (2) whether the selective serotonin reuptake inhibitor fluoxetine administered daily after an FST could affect the number of Fos-positive neurons in the NRM. Results revealed that the stress from repeated FSTs significantly increased the number of Fos-positive neurons in an NRM that had been affected by MM injury. Fluoxetine inhibited increases in the number of Fos-positive neurons in the NRM that occurred as a result of FSTs, but this was not observed in sham rats. These findings indicate that the stress from FSTs could increase nociceptive neural activity in an NRM that has experienced MM injury. This could be due, in part, to changes in serotonergic mechanisms.

    DOI： 10.2334/josnusd.19-0320

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  • Daily administration of Sake Lees (Sake Kasu) reduced psychophysical stress-induced hyperalgesia and Fos responses in the lumbar spinal dorsal horn evoked by noxious stimulation to the hindpaw in the rats. Reviewed

    Shimizu S, Nakatani Y, Kakihara Y, Taiyoji M, Saeki M, Takagi R, Yamamura K, Okamoto K

    Bioscience, Biotechnology, and Biochemistry   84 ( 1 )   159 - 170   2020.1

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    We tested whether Sake Lees (SL) had inhibitory effects on hyperalgesia in the hindpaw under psychophysical stress conditions. Male rats were subjected to repeated forced swim stress treatments (FST) from Day -3 to Day -1. Intraperiotoneal administration of SL which contained low concentration of ethanol (SLX) was conducted after each FST. On Day 0, formalin-evoked licking behaviors and Fos responses in the lumbar spinal cord (DH) and several areas within the rostral ventromedial medulla (RVM) were quantified as nociceptive responses. FST-induced hyperalgesia in the hindpaw was prevented by repeated SL and SLX treatments. Fos expression was significantly increased in DH and some areas within the RVM under FST, which was prevented by repeated SL or SLX. These findings indicated that daily administration of SL had the potential to alleviate stress-induced hyperalgesia.

    DOI： 10.1080/09168451.2019.1662278

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  • Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1. Reviewed

    Hatta A, Kurose M, Sullivan C, Okamoto K, Fujii N, Yamamura K, Meng ID

    Journal of neurophysiology   121 ( 6 )   2191 - 2201   2019.6

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  • Japanese Rice Wine can reduce psychophysical stress-induced depression-like behaviors and Fos expression in the trigeminal subnucleus caudalis evoked by masseter muscle injury in the rats. Reviewed

    Nakatani Y, Kakihara Y, Shimizu S, Kurose M, Sato T, Kaneoke M, Saeki M, Takagi R, Yamamura K, Okamoto K

    Bioscience, Biotechnology, and Biochemistry   83 ( 1 )   155 - 165   2019.1

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1080/09168451.2018.1524705

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    Other Link： https://search.jamas.or.jp/link/ui/2019253806

  • Inhibitory effects of fluoxetine, an antidepressant drug, on masseter muscle nociception at the trigeminal subnucleus caudalis and upper cervical spinal cord regions in a rat model of psychophysical stress Reviewed

    Yosuke Nakatani, Masayuki Kurose, Shiho Shimizu, Mana Hasegawa, Nobuyuki Ikeda, Kensuke Yamamura, Ritsuo Takagi, Keiichiro Okamoto

    Experimental Brain Research   236 ( 8 )   1 - 13   2018.5

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Verlag  

    DOI： 10.1007/s00221-018-5297-0

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  • TRIGEMINAL BRAINSTEM MODULATION OF PERSISTENT ORBICULARIS OCULI MUSCLE ACTIVITY IN A RAT MODEL OF DRY EYE Reviewed

    Mostafeezur Rahman, Kazunari Shiozaki, Keiichiro Okamoto, Randall Thompson, David A. Bereiter

    NEUROSCIENCE   349   208 - 219   2017.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neuroscience.2017.03.003

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  • Bilateral increases in ERK activation at the spinomedullary junction region by acute masseter muscle injury during temporomandibular joint inflammation in the rats Reviewed

    Masayuki Kurose, Hiroki Imbe, Yosuke Nakatani, Mana Hasegawa, Noritaka Fujii, Ritsuo Takagi, Kensuke Yamamura, Emiko Senba, Keiichiro Okamoto

    EXPERIMENTAL BRAIN RESEARCH   235 ( 3 )   913 - 921   2017.3

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00221-016-4852-9

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  • INHIBITION OF TEMPOROMANDIBULAR JOINT INPUT TO MEDULLARY DORSAL HORN NEURONS BY 5HT3 RECEPTOR ANTAGONIST IN FEMALE RATS Reviewed

    K. Okamoto, A. Katagiri, M. Rahman, R. Thompson, D. A. Bereiter

    NEUROSCIENCE   299   35 - 44   2015.7

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neuroscience.2015.04.037

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  • Sensitization of trigeminal brainstem pathways in a model for tear deficient dry eye Reviewed

    Mostafeezur Rahman, Keiichiro Okamoto, Randall Thompson, Ayano Katagiri, David A. Bereiter

    PAIN   156 ( 5 )   942 - 950   2015.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/j.pain.0000000000000135

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  • EVIDENCE FOR TRPA1 INVOLVEMENT IN CENTRAL NEURAL MECHANISMS IN A RAT MODEL OF DRY EYE Reviewed

    A. Katagiri, R. Thompson M. Rahman, K. Okamoto, A. Bereiter

    NEUROSCIENCE   290   204 - 213   2015.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neuroscience.2015.01.046

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  • Activation of rostral ventromedial medulla neurons by noxious stimulation of cutaneous and deep craniofacial tissues Reviewed

    Sergey G. Khasabov, Patrick Malecha, Joseph Noack, Janneta Tabakov, Keiichiro Okamoto, David A. Bereiter, Donald A. Simone

    JOURNAL OF NEUROPHYSIOLOGY   113 ( 1 )   14 - 22   2015.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/jn.00125.2014

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  • TRIGEMINAL PATHWAYS FOR HYPERTONIC SALINE- AND LIGHT-EVOKED CORNEAL REFLEXES Reviewed

    M. Rahman, K. Okamoto, R. Thompson, D. A. Bereiter

    NEUROSCIENCE   277   716 - 723   2014.9

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  • Posterior hypothalamic modulation of ocular-responsive trigeminal subnucleus caudalis neurons is mediated by Orexin-A and Orexin1 receptors Reviewed

    Ayano Katagiri, Keiichiro Okamoto, Randall Thompson, Mostafeezur Rahman, David A. Bereiter

    EUROPEAN JOURNAL OF NEUROSCIENCE   40 ( 4 )   2619 - 2627   2014.8

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  • POSTERIOR HYPOTHALAMIC MODULATION OF LIGHT-EVOKED TRIGEMINAL NEURAL ACTIVITY AND LACRIMATION Reviewed

    A. Katagiri, K. Okamoto, R. Thompson, D. A. Bereiter

    NEUROSCIENCE   246   133 - 141   2013.8

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  • Estrogen status and psychophysical stress modify temporomandibular joint input to medullary dorsal horn neurons in a lamina-specific manner in female rats Reviewed

    Keiichiro Okamoto, Randall Thompson, Ayano Katagiri, David A. Bereiter

    PAIN   154 ( 7 )   1057 - 1064   2013.7

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  • Trigeminal interpolaris/caudalis transition neurons mediate reflex lacrimation evoked by bright light in the rat Reviewed

    Keiichiro Okamoto, Akimasa Tashiro, Randall Thompson, Yasuhiro Nishida, David A. Bereiter

    EUROPEAN JOURNAL OF NEUROSCIENCE   36 ( 11 )   3492 - 3499   2012.12

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    DOI： 10.1111/j.1460-9568.2012.08272.x

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  • Temporomandibular joint-evoked responses by spinomedullary neurons and masseter muscle are enhanced after repeated psychophysical stress Reviewed

    Keiichiro Okamoto, Akimasa Tashiro, Zheng Chang, Randall Thompson, David A. Bereiter

    EUROPEAN JOURNAL OF NEUROSCIENCE   36 ( 1 )   2025 - 2034   2012.7

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    DOI： 10.1111/j.1460-9568.2012.08100.x

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  • Rapid Estrogenic Effects on TMJ-responsive Brainstem Neurons Reviewed

    A. Tashiro, K. Okamoto, D. A. Bereiter

    JOURNAL OF DENTAL RESEARCH   91 ( 2 )   210 - 214   2012.2

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    DOI： 10.1177/0022034511428156

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  • DIFFERENTIAL ASCENDING PROJECTIONS OF TEMPOROMANDIBULAR JOINT-RESPONSIVE BRAINSTEM NEURONS TO PERIAQUEDUCTAL GRAY AND POSTERIOR THALAMUS OF MALE AND FEMALE RATS Reviewed

    Z. Chang, K. Okamoto, D. A. Bereiter

    NEUROSCIENCE   203   230 - 243   2012.2

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    DOI： 10.1016/j.neuroscience.2011.11.042

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  • NEUROBIOLOGY OF ESTROGEN STATUS IN DEEP CRANIOFACIAL PAIN Reviewed

    David A. Bereiter, Keiichiro Okamoto

    TRANSLATING MECHANISMS OF OROFACIAL NEUROLOGICAL DISORDER   97   251 - 284   2011

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    DOI： 10.1016/B978-0-12-385198-7.00010-2

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  • Psychophysical stress increases the expression of phospho-CREB, Fos protein and neurokinin-1 receptors in superficial laminae of trigeminal subnucleus caudalis in female rats Reviewed

    Sara L. Duenes, Randy Thompson, Zheng Chang, Keiichiro Okamoto, David A. Bereiter

    NEUROSCIENCE LETTERS   486 ( 3 )   207 - 210   2010.12

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    DOI： 10.1016/j.neulet.2010.09.054

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  • ULTRAVIOLET IRRADIATION OF THE EYE AND Fos-POSITIVE NEURONS INDUCED IN TRIGEMINAL BRAINSTEM AFTER INTRAVITREAL OR OCULAR SURFACE TRANSIENT RECEPTOR POTENTIAL VANILLOID 1 ACTIVATION Reviewed

    Z. Chang, K. Okamoto, A. Tashiro, D. A. Bereiter

    NEUROSCIENCE   170 ( 2 )   678 - 685   2010.10

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    DOI： 10.1016/j.neuroscience.2010.07.019

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  • BEHAVIORAL AND NEUROPHYSIOLOGICAL CORRELATES OF NOCICEPTION IN AN ANIMAL MODEL OF PHOTOKERATITIS Reviewed

    A. Tashiro, K. Okamoto, Z. Chang, D. A. Bereiter

    NEUROSCIENCE   169 ( 1 )   455 - 462   2010.8

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    DOI： 10.1016/j.neuroscience.2010.04.034

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  • Bright light activates a trigeminal nociceptive pathway Reviewed

    Keiichiro Okamoto, Akimasa Tashiro, Zheng Chang, David A. Bereiter

    PAIN   149 ( 2 )   235 - 242   2010.5

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    DOI： 10.1016/j.pain.2010.02.004

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  • Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress Reviewed

    Hiroki Imbe, Keiichiro Okamoto, Tomohiro Donishi, Emiko Senba, Akihisa Kimura

    BRAIN RESEARCH   1329   103 - 112   2010.5

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    DOI： 10.1016/j.brainres.2010.03.006

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  • NMDA RECEPTOR BLOCKADE REDUCES TEMPOROMANDIBULAR JOINT-EVOKED ACTIVITY OF TRIGEMINAL SUBNUCLEUS CAUDALIS NEURONS IN AN ESTROGEN-DEPENDENT MANNER Reviewed

    A. Tashiro, K. Okamoto, D. A. Bereiter

    NEUROSCIENCE   164 ( 4 )   1805 - 1812   2009.12

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    DOI： 10.1016/j.neuroscience.2009.09.067

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  • CHRONIC INFLAMMATION AND ESTRADIOL INTERACT THROUGH MAPK ACTIVATION TO AFFECT TMJ NOCICEPTIVE PROCESSING BY TRIGEMINAL CAUDALIS NEURONS Reviewed

    A. Tashiro, K. Okamoto, D. A. Bereiter

    NEUROSCIENCE   164 ( 4 )   1813 - 1820   2009.12

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    DOI： 10.1016/j.neuroscience.2009.09.058

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  • BRIGHT LIGHT PRODUCES Fos-POSITIVE NEURONS IN CAUDAL TRIGEMINAL BRAINSTEM Reviewed

    K. Okamoto, R. Thompson, A. Tashiro, Z. Chang, D. A. Bereiter

    NEUROSCIENCE   160 ( 4 )   858 - 864   2009.6

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    DOI： 10.1016/j.neuroscience.2009.03.003

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  • Activation of ERK in the locus coeruleus following acute noxious stimulation Reviewed

    Hiroki Imbe, Keiichiro Okamoto, Tomohiro Donishi, Shintaro Kawai, Keisuke Enoki, Emiko Senba, Akihisa Kimura

    BRAIN RESEARCH   1263   50 - 57   2009.3

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  • OCULAR SURFACE-EVOKED Fos-LIKE IMMUNOREACTIVITY IS ENHANCED IN TRIGEMINAL SUBNUCLEUS CAUDALIS BY PRIOR EXPOSURE TO ENDOTOXIN Reviewed

    K. Okamoto, D. F. Bereiter, A. Tashiro, D. A. Bereiter

    NEUROSCIENCE   159 ( 2 )   787 - 794   2009.3

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    DOI： 10.1016/j.neuroscience.2008.12.015

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  • Morphine modulation of temporomandibular joint-responsive units in superficial laminae at the spinomedullary junction in female rats depends on estrogen status Reviewed

    A. Tashiro, K. Okamoto, D. A. Bereiter

    EUROPEAN JOURNAL OF NEUROSCIENCE   28 ( 10 )   2065 - 2074   2008.11

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    DOI： 10.1111/j.1460-9568.2008.06488.x

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  • ESTRADIOL REPLACEMENT MODIFIES c-fos EXPRESSION AT THE SPINOMEDULLARY JUNCTION EVOKED BY TEMPOROMANDIBULAR JOINT STIMULATION IN OVARIECTOMIZED FEMALE RATS Reviewed

    K. Okamoto, D. F. Bereiter, R. Thompson, A. Tashiro, D. A. Bereiter

    NEUROSCIENCE   156 ( 3 )   729 - 736   2008.10

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    DOI： 10.1016/j.neuroscience.2008.08.003

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  • Descending facilitation in chronic stress and chronic pain state Reviewed

    Emiko Senba, Hiroki Imbe, Keiichiro Okamoto

    Japanese Journal of Neuropsychopharmacology   28 ( 1 )   29 - 35   2008.2

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  • Activation of ERK in the rostral ventromedial medulla is involved in hyperalgesia during peripheral inflammation Reviewed

    Hiroki Imbe, Akihisa Kimura, Keiichiro Okamoto, Tomohiro Donishi, Fumiko Aikawa, Emiko Senba, Yasuhiko Tamai

    BRAIN RESEARCH   1187   103 - 110   2008.1

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    DOI： 10.1016/j.brainres.2007.10.075

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  • Differential effects of estradiol on encoding properties of TMJ units in laminae I and V at the spinomedullary junction in female rats Reviewed

    A. Tashiro, K. Okamoto, S. B. Milam, D. A. Bereiter

    JOURNAL OF NEUROPHYSIOLOGY   98 ( 6 )   3242 - 3253   2007.12

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  • Activation of central 5HT2A receptors reduces the craniofacial nociception of rats Reviewed

    K. Okamoto, H. Imbe, A. Kimura, T. Donishi, Y. Tamai, E. Senba

    NEUROSCIENCE   147 ( 4 )   1090 - 1102   2007.7

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    DOI： 10.1016/j.neuroscience.2007.05.012

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  • Efferent connections of the ventral auditory area in the rat cortex: implications for auditory processing related to emotion Reviewed

    A. Kimura, T. Donishi, K. Okamoto, H. Imbe, Y. Tamai

    EUROPEAN JOURNAL OF NEUROSCIENCE   25 ( 9 )   2819 - 2834   2007.5

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    DOI： 10.1111/j.1460-9568.2007.05519.x

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  • Effects of peripheral inflammation on activation of p38 mitogen-activated protein kinase in the rostral ventromedial medulla Reviewed

    Hiroki Imbe, Keiichiro Okamoto, Fumiko Aikawa, Akihisa Kimura, Tomohiro Donishi, Yasuhiko Tamai, Yasutomo Iwai-Liao, Emiko Senba

    BRAIN RESEARCH   1134 ( 1 )   131 - 139   2007.2

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    DOI： 10.1016/j.brainres.2006.11.091

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  • Contribution of peripheral 5-HT2A or 5-HT3 receptors to Fos expression in the trigeminal spinal nucleus produced by acute injury to the masseter muscle during persistent temporomandibular joint inflammation in rats Reviewed

    K. Okamoto, A. Kimura, T. Donishi, H. Imbe, Y. Nishie, H. Matsushita, Y. Tamai, E. Senba

    NEUROSCIENCE   143 ( 2 )   597 - 606   2006.12

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    DOI： 10.1016/j.neuroscience.2006.08.009

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  • Persistent monoarthritis of the temporomandibular joint region enhances nocifensive behavior and lumbar spinal Fos expression after noxious stimulation to the hindpaw in rats Reviewed

    K Okamoto, A Kimura, T Donishi, H Imbe, K Goda, K Kawanishi, Y Tamai, E Senba

    EXPERIMENTAL BRAIN RESEARCH   170 ( 3 )   358 - 367   2006.4

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    DOI： 10.1007/s00221-005-0218-4

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  • "Ventral" area in the rat auditory cortex: A major auditory field connected with the dorsal division of the medial geniculate body Reviewed

    T. Donishi, A. Kimura, K. Okamoto, Y. Tamai

    NEUROSCIENCE   141 ( 3 )   1553 - 1567   2006

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    DOI： 10.1016/j.neuroscience.2006.04.037

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  • Endotoxin-induced uveitis causes long-term changes in trigeminal subnucleus caudalis neurons Reviewed

    DA Bereiter, K Okamoto, A Tashiro, H Hirata

    JOURNAL OF NEUROPHYSIOLOGY   94 ( 6 )   3815 - 3825   2005.12

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    DOI： 10.1152/jn.00616.2005

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  • Effects of peripheral inflammation on activation of ERK in the rostral ventromedial medulla Reviewed

    H Imbe, K Okamoto, T Okamura, S Kumabe, M Nakatsuka, F Aikawa, Y Iwai-Liao, E Senba

    BRAIN RESEARCH   1063 ( 2 )   151 - 158   2005.11

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    DOI： 10.1016/j.brainres.2005.09.057

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  • Effect of persistent monoarthritis of the temporomandibular joint region on acute mustard oil-induced excitation of trigeminal subnucleus caudalis neurons in male and female rats Reviewed

    DA Bereiter, K Okamoto, DF Bereiter

    PAIN   117 ( 1-2 )   58 - 67   2005.9

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    DOI： 10.1016/j.pain.2005.05.013

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  • Differential modulation of TMJ neurons in superficial laminae of trigeminal subnucleus caudalis/upper cervical cord junction region of male and cycling female rats by morphine Reviewed

    K Okamoto, A Tashiro, H Hirata, DA Bereiter

    PAIN   114 ( 1-2 )   203 - 211   2005.3

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    DOI： 10.1016/j.pain.2004.12.013

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  • The role of peripheral 5HT2A and 5HT1A receptors on the orofacial formalin test in rats with persistent temporomandibular joint inflammation Reviewed

    K Okamoto, H Imbe, A Tashiro, A Kimura, T Donishi, Y Tamai, E Senba

    NEUROSCIENCE   130 ( 2 )   465 - 474   2005

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    DOI： 10.1016/j.neuroscience.2004.10.004

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  • Topography of projections from the primary and non-primary auditory cortical areas to the medial geniculate body and thalamic reticular nucleus in the rat Reviewed

    A Kimura, T Donishi, K Okamoto, Y Tamai

    NEUROSCIENCE   135 ( 4 )   1325 - 1342   2005

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    DOI： 10.1016/j.neuroscience.2005.06.089

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  • Central serotonin 3 receptors play an important role in the modulation of nociceptive neural activity of trigeminal subnucleus caudalis and nocifensive orofacial behavior in rats with persistent temporomandibular joint inflammation Reviewed

    K Okamoto, A Kimura, T Donishi, H Imbe, E Senba, Y Tamai

    NEUROSCIENCE   135 ( 2 )   569 - 581   2005

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    DOI： 10.1016/j.neuroscience.2005.06.032

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  • The effects of acute and chronic restraint stress on activation of ERK in the rostral ventromedial medulla and locus coeruleus Reviewed

    H Imbe, S Murakami, K Okamoto, Y Iwai-Liao, E Senba

    PAIN   112 ( 3 )   361 - 371   2004.12

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    DOI： 10.1016/j.pain.2004.09.015

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  • Blockade of peripheral 5HT3 receptor attenuates the formalin-induced nocifensive behavior in persistent temporomandibular joint inflammation of rat Reviewed

    K Okamoto, H Imbe, A Tashiro, S Kumabe, E Senba

    NEUROSCIENCE LETTERS   367 ( 2 )   259 - 263   2004.9

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    DOI： 10.1016/j.neulet.2004.06.017

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  • Increase of galanin-like immunoreactivity in rat hypothalamic arcuate neurons after peripheral nerve injury Reviewed

    H Imbe, T Abe, K Okamoto, M Sato, H Ito, S Kumabe, E Senba

    NEUROSCIENCE LETTERS   368 ( 1 )   102 - 106   2004.9

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    DOI： 10.1016/j.neulet.2004.06.073

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  • A novel class of neurons at the trigeminal subnucleus interpolaris/caudalis transition region monitors ocular surface fluid status and modulates tear production Reviewed

    H Hirata, K Okamoto, A Tashiro, DA Bereiter

    JOURNAL OF NEUROSCIENCE   24 ( 17 )   4224 - 4232   2004.4

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    DOI： 10.1523/JNEUROSCI.0381-04.2004

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  • Topography of corticothalamic projections from the auditory cortex of the rat Reviewed

    M Hazama, A Kimura, T Donishi, T Sakoda, Y Tamai

    NEUROSCIENCE   124 ( 3 )   655 - 667   2004

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    DOI： 10.1016/j.neuroscience.2003.12.027

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  • Galectin-1 is involved in the potentiation of neuropathic pain in the dorsal horn Reviewed

    H Imbe, K Okamoto, T Kadoya, H Horie, E Senba

    BRAIN RESEARCH   993 ( 1-2 )   72 - 83   2003.12

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    DOI： 10.1016/j.brainres.2003.08.064

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  • GABA(A) receptor activation modulates corneal unit activity in rostral and caudal portions of trigeminal subnucleus caudalis Reviewed

    H Hirata, K Okamoto, DA Bereiter

    JOURNAL OF NEUROPHYSIOLOGY   90 ( 5 )   2837 - 2849   2003.11

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    DOI： 10.1152/jn.00544.2003

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  • Response properties of TMJ units in superficial laminae at the spinomedullary junction of female rats vary over the estrous cycle Reviewed

    K Okamoto, H Hirata, S Takeshita, DA Bereiter

    JOURNAL OF NEUROPHYSIOLOGY   89 ( 3 )   1467 - 1477   2003.3

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    DOI： 10.1152/jn.00795.2002

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  • 5-HT2A receptor subtype in the peripheral branch of sensory fibers is involved in the potentiation of inflammatory pain in rats Reviewed

    K Okamoto, H Imbe, Y Morikawa, M Itoh, M Sekimoto, K Nemoto, E Senba

    PAIN   99 ( 1-2 )   133 - 143   2002.9

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    DOI： 10.1016/S0304-3959(02)00070-2

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  • A novel analgesic compound OT-7100 attenuates nociceptive responses in animal models of inflammatory and neuropathic hyperalgesia: A possible involvement of adenosinergic anti-nociception Reviewed

    T Yasuda, K Okamoto, T Iwamoto, S Miki, N Yoshinaga, S Sato, K Noguchi, E Senba

    JAPANESE JOURNAL OF PHARMACOLOGY   87 ( 3 )   214 - 225   2001.11

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    DOI： 10.1254/jjp.87.214

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  • Myofascial flap without skin for intra-oral reconstruction 2: Clinical studies Reviewed

    Takeshi Wada, Keiichirou Okamoto, Yasuhiro Nakanishi, Hideshi Nakano, Yoshinobu Iwagami, Nobuo Morita

    International Journal of Clinical Oncology   6 ( 3 )   143 - 148   2001

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    DOI： 10.1007/PL00012097

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  • Myofascial flap without skin for intra-oral reconstruction 1: Animal studies Reviewed

    Takeshi Wada, Keiichirou Okamoto, Yasuhiro Nakanishi, Yoshinobu Iwagami, Nobuo Morita

    International Journal of Clinical Oncology   6 ( 1 )   40 - 44   2001

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    DOI： 10.1007/PL00012078

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  • 国保橋本市民病院歯科口腔外科における顎顔面骨骨折症例の臨床統計的観察 Reviewed

    岡本 圭一郎, 松平 淳, 川島 稔弘

    和歌山医学   49 ( 2 )   113 - 117   1998.5

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  • 診断・治療に苦慮した口唇炎に対しトラニラスト(リザベン)の著効した1例

    川島 稔弘, 岡本 圭一郎, 坂本 忠幸

    診療と新薬   35 ( 1 )   59 - 61   1998.1

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  • 口腔症状を契機に発見された白血病症例の臨床的観察 Reviewed

    岡本 圭一郎, 和田 健, 大亦 哲司

    日本口腔科学会雑誌   47 ( 1 )   108 - 114   1998.1

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    DOI： 10.11277/stomatology1952.47.108

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  • 犬による顔面部咬傷の2例と文献的考察 Reviewed

    岡本 圭一郎, 川島 稔弘

    和歌山医学   48 ( 3 )   407 - 410   1997.8

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  • Intra-arterial infusion therapy with urokinase and antibacterial agents for diffuse sclerosing osteomyelitis of the mandible

    WADA Takeshi, HATA Sachiko, OOMATA Tetsuji, INBE Hiroki, OKAMOTO Keiichirou, MIYATA Kazuyuki, MORITA Nobuo, SAKAMOTO Tadayuki

    Journal of Oral Surgery Society of Japan   43 ( 5 )   413 - 415   1997.5

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    Three patients with diffuse sclerosing osteomyelitis of the mandible who had been treated by intra-arterial infusion of urokinase and antibacterial agents including fosfomycin were evaluated. All patients underwent decortication at the same time. They were all free from symptoms an average of 3 years 7 months after treatment.<BR>Urokinase and fosfomycin may cause the dissolution of biofilm, which prevents contact between antibacterial agents and causative organism. Thus, the intra-arterial infusion of urokinase, fosfomycin, and other antibacterial agents can efficiently eradicate bacteria in sclerotic bone in osteomyelitis.

    DOI： 10.5794/jjoms.43.413

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  • 口腔顎顔面外傷の入院症例における臨床統計的観察 Reviewed

    川島 稔弘, 岡本 圭一郎, 湯浅 祥司

    和歌山医学   48 ( 1 )   65 - 68   1997.2

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  • 下顎枝矢状分割後,顎動脈領域に発現した動脈瘤の1例 Reviewed

    岡本 圭一郎, 森田 展雄, 大亦 哲司

    日本口腔外科学会雑誌   42 ( 12 )   1221 - 1223   1996.12

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    DOI： 10.5794/jjoms.42.1221

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    Other Link： http://search.jamas.or.jp/link/ui/1997169728

  • 高校生集団における顎関節症の自覚症状に関する疫学的検討 Reviewed

    日本顎関節学会雑誌   8 ( 2 )   435 - 442   1996.9

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  • 口腔の脂肪腫の臨床病理学的検討 過去10年間の当科症例と文献的考察 Reviewed

    岡本 圭一郎, 和田 健, 川島 稔弘

    日本口腔外科学会雑誌   42 ( 3 )   270 - 276   1996.3

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    DOI： 10.5794/jjoms.42.270

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    Other Link： http://search.jamas.or.jp/link/ui/1996193849

  • Significance of combined neoadjuvant chemotherapy on oral cancer. 1. The clinical effects of cisplatin-vinblastine-peplomycin(CVP) combination chemotherapy included in two route administration and its prognostic significance.:1. The clinical effects of cisplatin-vinblastine-peplomycin (CVP) combination chemotherapy included in two route administration and its prognostic significance

    Wada Takeshi, Hata Sachiko, Morita Nobuo, Oomata Tetsuji, Inbe Hiroki, Okamoto Keiichirou, Matsuhira Jun, Buyo Yuka, Shinnoki Shigeki, Miyata Kazuyuki, Sakamoto Tadayuki, Kawashima Toshihiro, Yuasa Syoji, Harada Masakazu, Sakagami Takuya, Samukawa Toshiko

    Journal of Japanese Society of Oral Oncology   8 ( 1 )   8 - 15   1996

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    The therapeutic effects of neo-adjuvant chemotherapy administered by two route infusion of cisplatin and its antidote, sodium thiosulfate, and intravenous infusion of vinblastine and peplomycin were studied on 35 patients with previously untreated squamous cell carcinoma of the oral cavity, maxillary sinus, or oropharynx. The overall response rate to chemotherapy was 91.4%, and complete response rate was 57.1%. When the patients who died of a disease other than tumor were excluded, the cumulative 5-year survival rate was 100% in CR and 87.5% in PR plus NC. This chemotherapy could be carried out in a shorter time period because of the appropriate supporting therapy. Twelve out of 20 CR patients underwent conservative surgery, and they are all free from tumor and have good oral function. These data showed that this chemotherapy may be more effective for treatment of head and neck cancer. The results are preliminary, and additional studies using more patients are needed.

    DOI： 10.5843/jsot.8.8

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  • 食道癌発生後,6年間に口腔粘膜の4ヶ所から発生した多発癌の1症例と文献的考察 Reviewed

    OKAMOTO Keiichirou, WADA Takeshi, HARADA Masakazu, KAWASHIMA Toshihiro, INBE Hiroki, MORITA Nobuo, SAKAMOTO Tadayuki

    日本口腔腫瘍学会誌   7 ( 4 )   354 - 358   1995.12

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    DOI： 10.5843/jsot.7.354

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  • Differential Response Pattern of Oropharyngeal Pressure by Bolus and Dry Swallows Reviewed

    Mana Hasegawa, Masayuki Kurose, Keiichiro Okamoto, Yoshiaki Yamada, Takanori Tsujimura, Makoto Inoue, Taisuke Sato, Takatsune Narumi, Noritaka Fujii, Kensuke Yamamura

    Dysphagia   33 ( 1 )   83 - 90   2018.2

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer New York LLC  

    DOI： 10.1007/s00455-017-9836-9

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  • Guide to Enhancing Swallowing Initiation: Insights from Findings in Healthy Subjects and Dysphagic Patients. Reviewed

    Yamamura K, Kurose M, Okamoto K

    Current physical medicine and rehabilitation reports   6 ( 3 )   178 - 185   2018

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    DOI： 10.1007/s40141-018-0192-y

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  • Use of a Novel Device to Assess Intraoral and Intrapharyngeal Baropressure during Sound Production Reviewed

    Toshiki Sakuma, Masayuki Kurose, Keiichiro Okamoto, Mana Hasegawa, Noritaka Fujii, Yousuke Nakatani, Ritsuo Takagi, Taisuke Sato, Yasumitsu Kodama, Rei Ominato, Kensuke Yamamura, Yoshiaki Yamada

    FOLIA PHONIATRICA ET LOGOPAEDICA   68 ( 6 )   274 - 281   2016

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    DOI： 10.1159/000481530

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  • Chemical Sensing Regulates Mastication/Swallowing Reviewed

    Kensuke Yamamura, Masayuki Kurose, Keiichiro Okamoto

    CURRENT PHARMACEUTICAL DESIGN   22 ( 15 )   2279 - 2284   2016

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    DOI： 10.2174/1381612822666160216151150

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  • ストレス伝染は吻側延髄腹側部を変調させる

    KAJITA Piriyaprasath, 長谷川真奈, 長谷川真奈, 柿原嘉人, 藤井規孝, 山村健介, 岡本圭一郎

    Journal of Oral Biosciences Supplement (Web)   2023   2023

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  • 骨代謝に対する酒粕の調節機能の解析

    柿原嘉人, 岡本圭一郎, 山村健介

    Journal of Oral Biosciences Supplement (Web)   2023   2023

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  • 酒粕GABAによるストレス誘発痛の抑制機構の解明 Invited

    岡本圭一郎

    公益財団法人飯島唐十郎記念食品科学振興財団   34   30 - 37   2019.8

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  • 顎関節痛を調節する下行性疼痛制御系について Invited Reviewed

    黒瀬雅之, 岡本圭一郎

    日本顎関節学会雑誌   31   149 - 158   2019

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    File： 日本顎関節学会雑誌31.149-.2019.pdf

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  • 反復的な強制水泳がもたらす心理的ストレスは、吻側延髄腹内側部(RVM)における顎顔面領域での侵害情報伝達を変調する

    黒瀬 雅之, 長谷川 真奈, 清水 志保, 中谷 暢佑, 藤井 規孝, 佐藤 義英, 山村 健介, 岡本 圭一郎

    Journal of Oral Biosciences Supplement   2018   467 - 467   2018.9

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  • 情動ストレスによるセロトニン機構の変調は大縫線核および青斑核の咬筋侵害応答を増大させる

    清水 志保, 中谷 暢佑, 黒瀬 雅之, 長谷川 真奈, 高木 律男, 山村 健介, 岡本 圭一郎

    Journal of Oral Biosciences Supplement   2018   257 - 257   2018.9

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  • 日本酒によるストレス誘発性の咬筋侵害応答の軽減効果は日本酒含有エタノールの直接作用ではない

    中谷 暢佑, 柿原 嘉人, 清水 志保, 黒瀬 雅之, 佐伯 万騎男, 高木 律男, 山村 健介, 岡本 圭一郎

    Journal of Oral Biosciences Supplement   2018   260 - 260   2018.9

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  • 三叉神経支配領域への侵害刺激を受容する吻側延髄腹側部ニューロンの電気生理学的特性

    長谷川 真奈, 黒瀬 雅之, 岡本 圭一郎, 中谷 暢佑, 清水 志保, 山村 健介, 藤井 規孝

    新潟歯学会雑誌   48 ( 1 )   59 - 59   2018.6

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  • 強制水泳ストレスは顎顔面領域における吻側延髄腹側部での侵害受容を変調する

    黒瀬 雅之, 長谷川 真奈, 岡本 圭一郎, 中谷 暢佑, 清水 志保, 藤井 規孝, 山村 健介

    新潟歯学会雑誌   48 ( 1 )   58 - 59   2018.6

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  • 多チャネル容量性触圧センサを用いた頬粘膜の咀嚼時接触面圧測定

    長谷川 真奈, 黒瀬 雅之, 岡本 圭一郎, 渡辺 啓介, 新井 啓介, 佐藤 秋彦, 家亀 里佳, 山村 健介, 山田 好秋

    日本咀嚼学会雑誌   27 ( 2 )   115 - 115   2017.11

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  • 多チャネル容量性触圧センサを用いた咀嚼時の頬粘膜による接触面圧測定

    長谷川 真奈, 黒瀬 雅之, 岡本 圭一郎, 清水 志保, 中谷 暢佑, 山村 健介, 藤井 規孝, 高木 律男, 山田 好秋

    Journal of Oral Biosciences Supplement   2017   297 - 297   2017.9

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  • セロトニン再取り込み阻害薬は繰り返しストレスによる咬筋の侵害受容反応の増強を抑制する

    中谷 暢佑, 黒瀬 雅之, 清水 志保, 柿原 嘉人, 木口 哲郎, 長谷川 真奈, 佐伯 万騎男, 高木 律男, 山村 健介, 岡本 圭一郎

    Journal of Oral Biosciences Supplement   2017   463 - 463   2017.9

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  • 顎顔面皮膚および深部組織への侵害刺激がもたらす吻側廷髄腹側部ニューロンの応答特性

    黒瀬 雅之, 長谷川 真奈, 岡本 圭一郎, 清水 志保, 中谷 暢佑, 藤井 規孝, 高木 律男, 山田 好秋, 山村 健介

    Journal of Oral Biosciences Supplement   2017   456 - 456   2017.9

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  • 『酒は百薬の長』の根拠を科学的に解明するストレス誘発性の咬筋侵害受容反応に対する日本酒の影響について

    岡本 圭一郎, 中谷 暢佑, 黒瀬 雅之, 柿原 嘉人, 木口 哲郎, 長谷川 真奈, 藤井 規孝, 佐伯 万騎男, 高木 律男, 山村 健介

    Journal of Oral Biosciences Supplement   2017   462 - 462   2017.9

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  • セロトニン再取り込み阻害薬は繰り返しストレスによる咬筋の侵害受容反応の増強を抑制する

    中谷 暢佑, 岡本 圭一郎, 高木 律男

    日本顎関節学会雑誌   29 ( Suppl. )   136 - 136   2017.7

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  • 大気圧センサを用いた健常者の嚥下時咽頭内圧変化の測定

    長谷川 真奈, 岡本 圭一郎, 黒瀬 雅之, 山田 好秋, 山村 健介

    日本咀嚼学会雑誌   26 ( 2 )   98 - 98   2016.11

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  • 口唇随意運動時の脳活動の変化 fNIRSによる分析

    黒瀬 雅之, 岡本 圭一郎, 長谷川 真奈, 中谷 暢佑, 藤井 規孝, 山田 好秋, 佐藤 義英, 山村 健介, 増田 裕次

    Journal of Oral Biosciences Supplement   2016   515 - 515   2016.9

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  • 大気圧センサを用いた咽頭内圧測定システムによる嚥下機能の評価

    長谷川 真奈, 岡本 圭一郎, 黒瀬 雅之, 山田 好秋, 藤井 規孝, 山村 健介

    Journal of Oral Biosciences Supplement   2016   318 - 318   2016.9

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  • 持続性の顎関節炎が両側性の咬筋に痛覚過敏を引き起こす中枢メカニズム

    岡本 圭一郎, 黒瀬 雅之, 中谷 暢佑, 長谷川 真奈, 藤井 規孝, 高木 律夫, 山村 健介

    Journal of Oral Biosciences Supplement   2016   504 - 504   2016.9

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  • 大気圧センサを用いた嚥下時咽頭内圧変化の測定

    長谷川 真奈, 山田 好秋, 黒瀬 雅之, 岡本 圭一郎, 藤井 規孝, 山村 健介

    新潟歯学会雑誌   46 ( 1 )   49 - 49   2016.7

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  • 口腔生理学分野の研究最前線Frontier in the field of Oral Physiology 乾燥に"潤い"をもたらすメカニズムの解明

    黒瀬 雅之, 八田 あずさ, 岡本 圭一郎, Meng Ian D, 山村 健介

    Journal of Oral Biosciences Supplement   2015   112 - 112   2015.9

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  • A comment on experimental occlusal interference induces long-term masticatory muscle hyperalgesia in rats by Cao et al. Reviewed

    David A. Bereiter, Keiichiro Okamoto, Akimasa Tashiro, Donald R. Nixdorf

    PAIN   148 ( 3 )   519 - 519   2010.3

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    DOI： 10.1016/j.pain.2010.01.003

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  • ストレスと痛み 脳による疼痛の制御 Reviewed

    仙波 恵美子, 井辺 弘樹, 岡本 圭一郎

    日本神経精神薬理学雑誌   28 ( 1 )   29 - 35   2008.2

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  • ストレスと痛み : 脳による疼痛の制御

    仙波 恵美子, 井辺 弘樹, 岡本 圭一郎

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   27 ( 5 )   252 - 252   2007.11

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  • Contribution of peripheral 5HT2A or 5HT3 receptors to Fos expression in the trigeminal spinal nucleus (VSP) produced by the masseter muscle injury of rats

    Keiichiro Okamoto, Akihisa Kimura, Tomohiro Donishi, Yasuhiko Tamai

    NEUROSCIENCE RESEARCH   55   S188 - S188   2006

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  • 【痛みシグナルの制御機構と最新治療エビデンス】 疼痛の生理機構と分子メカニズム セロトニン受容体サブタイプと慢性痛

    岡本 圭一郎, 仙波 恵美子

    医学のあゆみ   211 ( 5 )   370 - 374   2004.10

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  • 5-HT_<2A> receptor expressing neurons in the rat sensory ganglia

    OKAMOTO Keiichiro, SEKIMOTO Masashi, NEMOTO Kiyomitsu, MORIKAWA Yoshihiro, SENBA Emiko

    Pain research : the journal of the Japanese Society for the Study of Pain = 日本疼痛学会誌   14 ( 3 )   13 - 13   1999.12

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  • A Case of Bilateral Nasolabial Cyst

    OKAMOTO KEIICHIRO, MORITA NOBUO, SAKAMOTO TADAYUKI

    12 ( 2 )   465 - 467   1999.10

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  • 和歌山県有田地方における住民の残存歯数と「8020運動」中間目標の達成状況について

    岡崎 佳生, 東 英代, 黒田 基嗣, 森田 展雄, 岡本 圭一郎, 河野 聡子, 玉置 敬一, 坂本 忠幸, 宮下 和久, 谷内 敏文, 松本 政信

    日本公衆衛生学会総会抄録集   54   1226 - 1226   1995.10

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Presentations

  • 公開シンポジウム「地域の特色を生かした大学の取組×学術とスタートアップの両輪での推進に向けて」 Invited

    岡本圭一郎

    日本学術会議若手アカデミー  2025.9 

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    Event date： 2025.9

    Language：Japanese  

    File： 387-s-0916.pdf

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  • アグマチンは顎顔面部の持続性炎症に伴う不安行動と中枢神経機能の変調を改善する

    岩本佑耶, 長谷川真奈, 岡本圭一郎, 山村健介, 藤井規孝

    日本補綴歯科学会第134回学術大会  2025.3 

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    Event date： 2025.5

    Language：Japanese   Presentation type：Poster presentation  

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  • トレッドミル運動の頻度が社会的敗北ストレスが引き起こす不安および顔面痛軽減効果に及ぼす影響とそのエピジェネティック基盤の検討

    長谷川真奈, 岡本圭一郎, 岩本佑耶, 山村健介, 藤井規孝

    日本補綴歯科学会第134回学術大会（長崎市）https://www.kwcs.jp/jps134/  2025.5 

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  • Agmatine improves impaired object recognition behaviors in a mouse model of craniofacial inflammation

    2025.3 

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    Event date： 2025.3

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  • 結局酒は百薬の長なのか？ Invited

    岡本圭一郎

    歯学研究を明るく楽しむ交流会・ 歯科領域でのAI活用の検討会  2024.11 

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    Event date： 2024.11 - 2024.12

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • アグマチンが顎顔面痛誘発性の不安行動に及ぼす影響

    長谷川 真奈, 岡本 圭一郎, 柿原 嘉人

    第44回日本歯科薬物療法学会学術大会（新潟市）  2024.7 

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  • 雄マウスの咬筋持続的炎症モデルにおける不安および後肢痛様反応に対 するアグマチンの予防的役割

    岩本 佑耶, ピリヤプラサト カジタ, 長谷川 真奈, 柿原 嘉人, 藤井 規孝, 山村 健介, 岡本 圭, 一郎

    第101回日本生理学会 (北九州、福岡）  2024.3 

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  • Effects of Rice- koji extracts and ergothioneine on anxiety- and pain-like responses under psychophysical stress conditions in mice

    Kajita Piriyaprasath, Yuya Iwamoto, Mana Hasegawa, Yoshito Kakihara, Noritaka Fujii, Kensuke Yamamura, Keiichiro Okamoto

    第101回日本生理学会 (北九州、福岡）  2024.3 

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  • ストレス伝染による咬筋侵害応答の増大と下行性疼痛制御系の変調について

    長谷川真奈, 岡本圭一郎

    第２８回口腔顔面痛学会学術大会（福岡）  2023.11 

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    Language：Japanese   Presentation type：Poster presentation  

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  • Activation of posterior belly of digastric muscle during swallowing.

    Yuhei Tsutsui, Takanori Tsujimura, Kajita Piriyaprasath, Titi Chotirungsan, Jin Magara, Keiichiro Okamoto, Kensuke Yamamura, Takeyasu Maeda, Makoto Inoue

    31st Dysphagia Research Society Annual Meeting. (San Francisco, USA)  2023.3 

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    Event date： 2023.3

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  • Effect of Sake lees (sake-kasu) on osteoblastic differentiation and bone metabolism.

    2023.3 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Functional role of posterior digastric muscle during deglu1tition.

    Yuhei Tsutsui, Takanori Tsujimura, Kajita Piriyaprasath, Titi Chotirungsan, Jin Magara, Keiichiro Okamoto, Kensuke Yamamura, Takeyasu Maeda, Makoto Inoue

    Neuroscience (SFN) 2022 (San Diego, USA)  2022.11 

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    Event date： 2022.11 - 2022

    Language：English   Presentation type：Poster presentation  

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  • Functional role of posterior belly of digastric muscle in swallowing in the rat.

    Yuhei Tsutsui, Titi Chotirungsan, Satomi Kawada, Kajita Piriyaprasath, Jin Magara, Takanori Tsujimura, Keiichiro Okamoto, Kensuke Yamamura, Makoto Inoue

    第28回日本摂食嚥下リハビリテーション学会学術大会，幕張メッセ（千葉県・千葉市）  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Poster presentation  

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  • 米発酵エキスが象牙芽細胞様細胞(KN-3)のタンパク質発現におよぼす影響について

    岡本圭一郎, 柿原嘉人, 佐伯万騎男

    第40回歯科薬物療法学会 (横浜市）  2020.6 

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    Event date： 2020.6 - 2020.7

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Stress, No Enemy, Just Life! Managing psychological stress, Can Sake HELP? Invited

    Keiichiro Okamoto

    Mini lecture series, University of Peradeniya (Kandy, Sri Lanka)  2025.5 

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  • 米発酵エキスと健康：歯学部発の研究内容を紹介します Invited

    岡本圭一郎

    令和6年度第4回日本酒学セミナー（新潟大学 Zoom Live）  2025.2 

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    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  • 酒粕の骨代謝への効果

    Stephanny Castillo-Quispe, 柿原嘉人, 岡本圭一郎

    第44回日本歯科薬物療法学会学術大会  2024.7 

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  • 骨代謝に対する酒粕の調節機能の解析

    柿原 嘉人, 岡本 圭一郎, 山村 健介

    第６５回基礎歯科医学会（東京）  2023.9 

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  • ストレス伝染は吻側延髄内側部を変調させる

    Piriyaprasath Kajita, 長谷川 真奈, 柿原 嘉人, 藤井 規孝, 山村 健介, 岡本 圭一郎

    第６５回基礎歯科医学会（東京）  2023.9 

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  • Effects of stress contagion on anxiety- and orofacial pain-like responses with brain activation in mice.

    Kajita Piriyaprasath, Mana Hasegawa, Yoshito kakihara, Keiichiro Okamoto, Noritaka Fujii, Kensuke Yamamura.

    第56回新潟歯学会  2023.4 

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  • Effects of the contagion of social defeat stress on masseter muscle nociception in male mice.

    2023.3 

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  • 新潟発・生活習慣の工夫による健康増進法 Invited

    岡本圭一郎

    大阪大学歯学部大学院特別講義  2023.2 

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    Language：Japanese   Presentation type：Oral presentation (invited, special)  

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  • 米由来食品でストレスを解消する Invited

    岡本圭一郎

    令和４年度後期 新潟大学公開講座  2022.11 

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  • 百薬の長「日本酒」のヒミツ Invited

    岡本圭一郎

    令和４年度 「そのき市民学級 人生百年時代 賢く生きる」  2022.10 

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  • 顎関節症の痛み研究最前線 Invited

    岡本圭一郎

    一般社団法人日本顎関節学会 第 53 回学術講演会  2022.2 

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  • トレッドミル走は社会的敗北ストレスが引き起こす咬筋痛を軽減する

    長谷川真奈, 岡本圭一郎

    第25回日本口腔顔面痛学会学術大会  2020.11 

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  • 繰り返しトレッドミル走は社会的敗北ストレスによる顎顔面領域の侵害応答を抑制する

    長谷川真奈, 岡本圭一郎, 藤井規孝, 山村健介

    第６２回歯科基礎医学会学術大会  2020.9 

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  • Talking about Japanese Culture ~Is Sake the best of a hundred medicine? ~ Invited

    Keiichiro Okamoto

    2020.2 

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  • 顎顔面部への侵害刺激による吻側延髄腹内側部(RVM)の興奮性は繰り返しストレスによって変化する

    長谷川真奈, 黒瀬雅之, 岡本圭一郎, 藤井規孝, 山村健介

    三叉神経系領域の感覚ー運動統合機構研究会（軽井沢）  2019.11 

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  • 酒粕エキスが象牙芽細胞様細胞の分化におよぼす影響

    K Okamoto, Y Kakihara, L Thant, A Washio, C Kitamura, K Yamamura, M Saeki

    第６１回歯科基礎医学会  2019.10 

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  • Sake (Japanese Rice Wine) reduces Fos responses in the medullary dorsal horn under psychophysical stress conditions in the rats. Invited International conference

    Okamoto Keiichiro

    Store Kro Club  2019.6 

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  • Psychological stress modulates On- and Off-cell activity in the rostral ventromedial medulla. International conference

    Masayuki Kurose, Mana Hasegawa, Yosuke Nakatani, Shiho Shimizu, Noritaka Fujii, Yoshihide Satoh, Kensuke Yamamura, Keiichiro Okamoto

    FAOPS 2019 (Kobe Japan)  2019.3 

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  • Effect of repeated and acute psychophysical stress on masseter muscle nociception in the trigeminal subnucleus caudalis region of the rats. International conference

    Shiho Shimizu, Yoshito Kakihara, Mayumi Taiyoji, Yosuke Nakatani, Nobuyuki Ikeda, Makio Saeki, Ritsuo Takagi, Kensuke Yamamura, Keiichiro Okamoto

    FAOPS 2019 (Kobe, Japan)  2019.3 

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  • Brain Mechanisms for enhanced masseter muscle nociception under psychophysical stress conditions. Invited International conference

    岡本圭一郎

    2019 International Niigata-Taiwan Universities Collaborative Dental Research Symposium（Taipei, Taiwan)  2019.3 

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  • 第23回うま味研究助成成果発表会 Invited

    岡本圭一郎

    うま味研究会（東京）  2019.1 

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  • 日本酒は百薬の長を科学的に解明する方法 Invited

    岡本圭一郎

    ライスエキスポ 2018 （新潟市）  2018.11 

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  • Modulatory effects of psychological stress on descending pain controls Invited

    Oral Neuroscience 2018 （大阪）  2018.10 

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  • ストレスと日本酒 Invited

    岡本圭一郎

    日本酒学シンポジウム（新潟市）  2018.8 

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  • 教育講演 顎関節痛を調節する下行性疼痛制御機構 Invited

    岡本圭一郎

    日本口腔顔面痛学会（北九州市）  2018.7 

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  • Psychophysical Stress Enhances Orofacial Nociception in the Rostral Ventromedial Medulla International conference

    Shiho Shimizu, Yosuke Nakatani, Masayuki Kurose, Mana Hasegawa, Nobuyuki Ikeda, Noritaka Fujii, Ritsuo Takagi, Kensuke Yamamura, Keiichiro Okamoto

    2018.7  IADR

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    Venue：London  

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  • Japanese Rice Wine, Sake, inhibits Stress-Induced Jaw Muscle Nociception International conference

    Keiichiro Okamoto, Yosuke Nakatani, Shiho Shimizu, Masayuki Kurose, Yoshito Kakihara, Makio Saeki, Ritsuo Takagi, Kensuke Yamamura

    2018.7  IADR

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    Venue：London  

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  • Japanese Rice Wine (Sake) reduced enhanced masseter muscle nociception under repeated forced swim stress conditions in rats

    Keiichiro Okamoto, Yosuke Nakatani, Shiho Shimizu, Masayuki Kurose, Yoshito kakihara, Ritsuo Takagi, Kensuke Yamamura

    the 95th Annual Meeting of the Physiological Society of Japan  2018  Physiological Society of Japan

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    Venue：Takamatsu  

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  • Modulatory effect of repeated-forced swim stress on orofacial nociception at rostral ventromedial medulla (RVM)

    Masayuki Kurose, Mana Hasegawa, Shiho Shimizu, Yousuke Nakatani, Noritaka Fujii, Kensuke Yamamura, Keiichiro Okamoto

    第51回新潟歯学会総会  2018  Niigata Dental Society

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    Venue：Niigata  

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  • 三叉神経支配領域への侵害刺激を受容する吻側延髄腹側部ニューロンの電気生理学的特性

    長谷川真奈, 黒瀬雅之, 岡本圭一郎, 中谷暢佑, 清水志保, 山村健介, 藤井規孝

    第51回新潟歯学会総会  2018  Niigata Dental Society

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    Venue：Niigata  

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  • sychophysical stress increases nociceptive neural activities evoked by masseter muscle injury in the rostral ventral medulla (RVM) in rats. International conference

    Shiho Shimizu, Yosuke Nakatani, Masayuki Kurose, Kensuke Yamamura, Ritsuo Takagi, Keiichiro Okamoto

    the 95th Annual Meeting of the Physiological Society of Japan  2018  Physiological Society of Japan

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    Venue：Takamatsu  

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  • うまみは減塩につながるか？ 塩味応答性の弧束核ニューロンに対するうまみ刺激の影響

    渡部清人, 黒瀬雅之, 岡本圭一郎, 山村健介

    日本咀嚼学会第29回学術大会  2018  Japanese Society for Mastication Science and Health Promotion

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    Venue：Matsumoto  

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  • Modulatory effect of psychophysical stress on orofacial nociception at the rostral ventromedial medulla in the rats International conference

    Masayuki Kurose, Mana Hasegawa, Shiho Shimizu, Yousuke Nakatani, Noritaka Fujii, Kensuke Yamamura, Keiichiro Okamoto

    2018  Society of Neuroscience

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    Venue：San Diego  

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  • Psychological stress induced by repeated forced swim stress modulate the orofacial nociception at the rostral ventromedial medulla in the rats

    Masayuki Kurose, Mana Hasegawa, Shiho Shimizu, Yousuke Nakatani, Noritaka Fujii, Yoshihide Satoh, Kensuke Yamamura, Keiichiro Okamoto

    第60回 歯科基礎医学会学術大会  2018  Japanese Association for Oral Biology

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    Venue：Shiojiri  

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  • ディープラーニングによる 「食べ易さ」「飲み込み易さ」 判定の可能性

    黒瀬 雅之, 長谷川 真奈, 岡本 圭一郎, 山田 好秋, 山村 健介, 佐藤 大祐

    日本咀嚼学会第29回学術大会  2018  Japanese Society for Mastication Science and Health Promotion

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    Venue：Matsumoto  

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  • 顎顔面皮膚および深部組織への侵害刺激がもたらす吻側廷髄腹側部ニューロンの応答特性

    黒瀬雅之, 長谷川真奈, 岡本圭一郎, 清水志保, 中谷暢佑, 藤井規孝, 高木律男, 山田好秋, 山村健介

    第59回 歯科基礎医学会学術大会  2017  歯科基礎医学会

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    Venue：Shiojiri  

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  • 多チャネル容量性触圧センサを用いた頬粘膜の咀嚼時接触面圧測定

    長谷川真奈, 黒瀬雅之, 岡本圭一郎, 渡辺啓介, 新井啓介, 佐藤秋彦, 家亀里佳, 山村健介, 山田好秋

    日本咀嚼学会第28回学術大会  2017  日本咀嚼学会

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    Venue：Tokyo  

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  • Effect of repeated and acute psychophysical stress on masseter muscle nociception in the trigeminal subnucleus caudalis region of the rats International conference

    Yosuke Nakatani, Keiichiro Okamoto, Masayuki Kurose, Mana Hasegawa, Noritaka Fujii, Ritsuo Takagi, Kensuke Yamamura

    the 94th Annual Meeting of the Physiological Society of Japan  2017  Physiological Society of Japan

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    Venue：Sapporo  

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  • 『酒は百薬の長』の根拠を科学的に解明するストレス誘発性の咬筋侵害受容反応に対する日本酒の影響について

    岡本圭一郎, 中谷暢佑, 黒瀬雅之, 柿原嘉人, 木口哲郎, 長谷川真奈, 藤井規孝, 佐伯万騎男, 高木律男, 山村健介

    第59回 歯科基礎医学会学術大会  2017  歯科基礎医学会

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    Venue：Shiojiri  

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  • セロトニン再取り込み阻害薬は繰り返しストレスによる咬筋の侵害受容反応の増強を抑制する

    中谷暢佑, 黒瀬雅之, 清水志保, 柿原嘉人, 木口哲郎, 長谷川真奈, 佐伯万騎男, 高木律男, 山村健介, 岡本 圭一郎

    第59回 歯科基礎医学会学術大会  2017  歯科基礎医学会

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    Venue：Shiojiri  

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  • 多チャネル容量性触圧センサを用いた咀嚼時の頬粘膜による接触面圧測定

    長谷川真奈, 黒瀬雅之, 岡本圭一郎, 清水志保, 中谷暢佑, 山村健介, 藤井規孝, 高木律男, 山田好秋

    第59回 歯科基礎医学会学術大会  2017  歯科基礎医学会

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    Venue：Shiojiri  

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  • 大気圧センサを用いた健常者の嚥下時咽頭内圧変化の測定

    長谷川真奈, 山田好秋, 黒瀬雅之, 岡本圭一郎, 山村健介

    日本咀嚼学会第27回学術大会  2017  日本咀嚼学会

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    Venue：Hiroshima  

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  • Bilateral Increases in ERK Activation at the Spinomedullary Junction Region and Orofacial Nocifensive Behavioral Activity by Masseter Muscle Stimulation During Temporomandibular Joint Inflammation in the Rat International conference

    Keiichiro Okamoto, Masayuki Kurose, Hiroki Imbe, Emiko Senba, Kensuke Yamamura

    16th World Congress on Pain  2017  IASP

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    Venue：Yokohama  

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  • 口唇随意運動時の脳活動の変化 fNIRSによる分析

    黒瀬雅之, 岡本圭一郎, 長谷川真奈, 中谷暢佑, 藤井規孝, 山田好秋, 佐藤義英, 山村健介, 増田 裕次

    第58回 歯科基礎医学会学術大会  2016  歯科基礎医学会

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    Venue：Sapporo  

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  • 大気圧センサを用いた健常者の嚥下時咽頭内圧変化の測定

    長谷川真奈, 山田好秋, 黒瀬雅之, 岡本圭一郎, 山村健介

    日本咀嚼学会第27回学術大会  2016  日本咀嚼学会

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    Venue：Hiroshima  

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  • Measurements of Pharyngeal Barometric Pressure During Swallowing in the Healthy Subjects

    Mana Hasegawa, Keiichiro Okamoto, Masayuki Kurose, Takanori Tsujimura, Makoto Inoue, Noritaka Fujii, Yoshiaki Yamada, Kensuke Yamamura

    第22 回日本摂食嚥下リハビリテーション学会学術大会  2016  日本摂食嚥下リハビリテーション学会

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    Venue：Niigata  

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  • Bilateral Increases in ERK Activation at the Spinomedullary Junction Region and Orofacial Nocifensive Behavioral Activity by Masseter Muscle Stimulation During Temporomandibular Joint Inflammation in the Rat International conference

    Keiichiro Okamoto, Masayuki Kurose, Hiroki Imbe, Emiko Senba, Kensuke Yamamura

    16th World Congress on Pain  2016  IASP

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    Venue：Yokohama  

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  • 持続性の顎関節炎が両側性の咬筋に痛覚過敏を引き起こす中枢メカニズム

    岡本圭一郎, 黒瀬雅之, 中谷暢佑, 長谷川真奈, 藤井規孝, 高木律男, 山村健介

    第58回 歯科基礎医学会学術大会  2016  歯科基礎医学会

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    Venue：Sapporo  

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  • Dry eye sensitizes cold cells to capsaicin-mediated inhibition via TRPV1. International conference

    Masayuki Kurose, Azusa Hatta, Keiichiro Okamoto, Kensuke Yamamura, Ian D. Meng

    the 93th Annual Meeting of the Physiological Society of Japan  2016  Physiological Society of Japan

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    Venue：Sapporo  

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  • 乾燥に"潤い"をもたらすメカニズムの解 明. Invited

    黒瀬雅之, 八田あずさ, 岡本圭一郎, Meng ID, 山, 村健介

    第57回 歯科基礎医学会学術大会  2016  歯科基礎医学会

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    Venue：Niigata  

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  • 大気圧センサを用いた咽頭内圧測定システムによる嚥下機能の評価

    長谷川真奈, 岡本圭一郎, 黒瀬雅之, 山田好秋, 藤井 規孝, 山村 健介

    第58回 歯科基礎医学会学術大会  2016  歯科基礎医学会

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    Venue：Sapporo  

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  • Visual-feedback を用 いた口唇随意閉鎖運動時の脳活動の変化：fNIRS に よる分析

    黒瀬雅之, 増田裕次, 竹花快恵, 井上正雄, 岡本圭一郎, 山本悠, 山村健介

    第 18 回日本ヒト脳機能マッピング学会  2016  日本ヒト脳機能マッピング学会

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    Venue：Kyoto  

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  • Cerebral blood flow during adjusting voluntary lip-closing force using the visual feedback International conference

    Yuji Masuda, Masayuki Kurose, Yoshie Takehana, Keiichiro Okamoto, Kensuke Yamamura

    the 93th Annual Meeting of the Physiological Society of Japan  2016  Physiological Society of Japan

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    Venue：Sapporo  

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  • photophobia（羞明）の神経機構 Invited

    岡本圭一郎

    第21回日本口腔顔面痛学会学術大会  2016  日本口腔顔面痛学会学術大会

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    Language：Japanese  

    Venue：Yokohama  

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  • Bright light activates trigeminal pathways Invited International conference

    Keiichiro Okamoto, Akimasa Tasshiro, Masayuki Kurose, Kensuke Yamamura, David A Bereiter

    the 94th Annual Meeting of the Physiological Society of Japan  2016  Physiological Society of Japan

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    Language：English  

    Venue：Sapporo  

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  • A new method for the study of velopharyngeal function using digital barometer. International conference

    Mana Hasegawa, Keiichiro Okamoto, Masayuki Kurose, Yoshiaki Yamada, Kensuke Yamamura

    the 93th Annual Meeting of the Physiological Society of Japan  2016  Physiological Society of Japan

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    Language：English   Presentation type：Poster presentation  

    Venue：Sapporo  

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  • 乾燥に"潤い"をもたらすメカニズムの解 明.

    黒瀬雅之, 八田あずさ, 岡本圭一郎, Meng ID, 山, 村健介

    第57回 歯科基礎医学会学術大会  2015  歯科基礎医学会

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    Language：Japanese  

    Venue：Niigata  

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  • photophobia（羞明）の神経機構 Invited

    岡本圭一郎

    第21回日本口腔顔面痛学会学術大会  2012  日本口腔顔面痛学会学術大会

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    Language：Japanese  

    Venue：Yokohama  

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  • Repeated treadmill running exercises reduced orofacial hyperalgesia following social defeat stress in mice.

    Mana Hasegawa, Keiichiro Okamoto, Noritaka Fujii, Kensuke Yamamura

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    Language：Japanese   Presentation type：Oral presentation (general)  

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Research Projects

  • Daily Administration of Agmatine Reduced Anxiety-like Behaviors and Neural Responses in the Brains of Male Mice with Persistent Inflammation in the Craniofacial Region

    2025.8

    System name：令和７年度新潟大学大学院生・国際誌掲載奨励プログラム

    Research category：新潟大学次世代研究者挑戦的研究プログラム論文投稿支援事業採択論文

    Awarding organization：新潟大学

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    Authorship：Principal investigator 

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  • Elucidation of the central nervous system mechanism by which stress-induced modulation of higher brain function increases orofacial pain

    Grant number：24K13111

    2024.4 - 2027.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • Effects of treadmil running on masseter muscle pain under psychological stress conditions.

    Grant number：23K09391

    2023.4 - 2026.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • Development of comprehensive dietary support model for the elderly with dementia

    Grant number：22H03375

    2022.4 - 2026.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）

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  • 遺伝性口顎部ジストニアの病態解明に向けた神経基盤の解明

    Grant number：21K10169

    2021.4 - 2024.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    黒瀬 雅之, 竹林 浩秀, 吉岡 望, 山村 健介, 佐藤 大祐, 森川 和政, 岡本 圭一郎

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    不随意な筋の協調障害により運動動作が障害されるジストニアの一症状である口顎部(オーラル)ジストニアは、詳細な病態が明らかになっておらず疾患に対する包括的な理解が進んでいない。本研究計画では、全身性ジストニア様の運動障害を呈するDst 遺伝子 (細胞骨格リンカータンパク質をコードし、変異によりニューロパチーを引き起こす) 変異マウスを用いて、①病態モデル確立のための表現型解析 ②顎口腔系で発症する不随意運動の原因部位の探索について研究を行うことを計画している。具体的には、先行研究で原因部位の候補とした脳幹・感覚神経系それぞれに部位選択的にDst発現を抑制したcKOマウス、部位選択的にDst発現を回復したcRescueマウスを作成し、電気生理学・組織学実験による詳細な表現系解析を行い、発症する症状の比較により原因部位を明らかとする。研究初年度に当たる本年度は、上述した遺伝子組み換え動物の開発元である新潟大学医学部からの凍結胚の譲渡並びに繁殖を実施するための法的手続きや実験・飼育環境の整備を中心に行った。さらに、電気生理学実験を実施するに当たり、慢性実験系を計画していることから、慢性実験記録系を確立するため、C57B6/Jのマウスを用いて記録筋電図電極や農繁電極の装着方法を探索し、個体で安定した記録環境の構築を行ってきた。実験個体に対しては、本研究の目的である自由行動下での咀嚼運動を行わさせ、物性の異なる食品咀嚼時の咀嚼運動を記録し解析を行った。

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  • 運動療法がストレス誘発性の顎顔面痛を軽減する脳メカニズム

    2019.4 - 2022.3

    Awarding organization：日本学術振興会 基盤研究C

    岡本圭一郎

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    Authorship：Principal investigator  Grant type：Competitive

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  • 酒粕トリプトファンが社会的敗北ストレスに起因する痛みと睡眠障害を改善する脳神経機構の解明

    2018.9 - 2019.8

    Awarding organization：公益財団法人 ひと・健康・未来研究財団

    岡本圭一郎

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    Authorship：Principal investigator  Grant type：Competitive

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  • 介護予防促進のための『むせる』を予測するシステムの開発

    2018.4 - 2022.3

    System name：基盤研究B

    Awarding organization：日本学術振興会

    山村健介

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    Grant type：Competitive

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  • 孤束核の塩味応答性神経細胞の興奮性が、うま味刺激によって増大するメカニズムの解明

    2018.4 - 2020.3

    System name：研究助成

    Awarding organization：うまみ研究会

    岡本圭一郎

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    Authorship：Principal investigator  Grant type：Competitive

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  • 酒粕GABAによるストレス誘発性のウツ・痛みの軽減機構の解明

    2018.4 - 2019.3

    Awarding organization：公益財団法人飯島藤十郎記念食品科学振興財団

    岡本圭一郎

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    Authorship：Principal investigator  Grant type：Competitive

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  • ストレスが顎関節痛を増強させる脳神経メカニズム

    2016.4 - 2019.3

    System name：基盤研究C

    Awarding organization：日本学術振興会

    岡本圭一郎

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    Authorship：Principal investigator  Grant type：Competitive

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  • ラットの三叉神経脊髄路核尾側亜核の5HT2A受容体が顎顔面痛におよぼす影響と性差

    Grant number：17791326

    2005.4 - 2006.3

    System name：若手研究B

    Research category：若手研究(B)

    Awarding organization：日本学術振興会

    岡本圭一郎

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    Authorship：Principal investigator  Grant type：Competitive

    申請者は電気生理学的、行動学的、免疫組織化学的手法を用い、中枢および末梢神経系における5HT2A,5HT3受容体の顎顔面部侵害受容における役割について検討した。
    1)顎関節炎症モデルにおいて咬筋の5HT2A,5HT3受容体をそれぞれ拮抗薬でブロックしておく。続いて同部へのホルマリン刺激を行うと三叉神経脊髄路核尾側亜核に発現するFos陽性細胞数は有意に減少した。つまりこれら末梢における受容体は顎顔面部侵害受容反応に深く関係し、痙痛/痛覚過敏を促進させる役割のあることを示唆するものである。(Okamoto et al. Neuroscience 143.597-606.2006)。また顎関節の持続性炎症モデルラットでは後肢においても痛覚過敏を起こす事を確認した(Okamoto et al. Experimental Brain Research 170.358-367.2006)。
    2)さらに顎関節非炎症モデルラットを用い、三叉神経脊髄路核尾側亜核の5HT2A受容体を活性化させておく。そして同部の侵害受容ニューロンの興奮性の変化を細胞外記録、およびFos免疫組織化学的手法を用い検索した。結果、咬筋へのホルマリン刺激、顔面皮膚への侵害機械刺激によって引き起こされる神経興奮はvehicle群と比較して有意に低下した。さらに大槽内への5HT2A受容体作動薬の投与しておくと、ホルマリンの咬筋刺激によって引き起こされる顎顔面部疼痛関連行動は有意に短縮した。つまり中枢神経系における5HT2A受容体活性は顎顔面部侵害受容反応を抑制する可能性を示唆するものである。
    (現在、投稿中)。
    以上の実験はmaleラットで行ったが、今後はfemaleラットを用い三叉神経脊髄路核尾側亜核の5HT2A受容体の役割がMaleと異なるか否かについて検索を行う。

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Teaching Experience (researchmap)

  • 日本酒学概論V

    2023.4
    Institution name：新潟大学大学日本酒学センター

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  • 生理学1

    Institution name：新潟大学大学院医歯学総合研究科（歯学部歯学科 ２年）

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  • 口腔生理学

    Institution name：新潟大学大学院医歯学総合研究科（歯学部歯学科 ３年）

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  • 生理学2

    Institution name：新潟大学大学院医歯学総合研究科（歯学部歯学科 ２年）

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  • 機能生理学

    Institution name：新潟大学工学部

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  • 人体の解剖と生理

    Institution name：明倫短期大学・歯科衛生士科

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  • 人体のしくみ

    Institution name：新潟大学大学院医歯学総合研究科 口腔生命福祉学科 ２年

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  • 早期臨床実習2B（バイタルサイン）

    Institution name：新潟大学歯学部 口腔生命福祉学科 2年

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  • 歯科薬理学

    Institution name：新潟大学大学院医歯学総合研究科（歯学部歯学科）

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  • 歯学研究演習

    Institution name：新潟大学大学院医歯学総合研究科（歯学部歯学科 ２年）

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Teaching Experience

  • 日本酒学概論V(医歯学・保健学)

    2023
    Institution name：新潟大学

  • 歯学研究演習

    2023
    Institution name：新潟大学

  • 歯科薬理学

    2022.4
    -
    2021
    Institution name：新潟大学

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    Level：Undergraduate (specialized) 

  • 早期臨床実習IIB

    2022
    Institution name：新潟大学

  • 神経科学演習IIA

    2021
    Institution name：新潟大学

  • 基礎歯学ｺｰｽﾜｰｸ(顎口腔機能学ベーシックコースI)

    2021
    Institution name：新潟大学

  • 神経科学演習IA

    2021
    Institution name：新潟大学

  • 神経科学演習IIB

    2021
    Institution name：新潟大学

  • 基礎歯学ｺｰｽﾜｰｸ(顎口腔機能学ベーシックコースII)

    2021
    Institution name：新潟大学

  • 神経科学演習IB

    2021
    Institution name：新潟大学

  • 人体のしくみ

    2019
    Institution name：新潟大学

  • 口腔生理学

    2018
    Institution name：新潟大学

  • 神経科学演習ⅡA

    2018
    Institution name：新潟大学

  • 生理学Ⅱ

    2017
    Institution name：新潟大学

  • 生理学Ⅰ

    2017
    Institution name：新潟大学

  • 機能生理学

    2017
    Institution name：新潟大学

  • 神経科学演習ⅠB

    2017
    Institution name：新潟大学

  • 神経科学演習ⅠA

    2017
    Institution name：新潟大学

  • 基本生理学

    2016
    -
    2020
    Institution name：新潟大学

  • 器官生理学

    2016
    -
    2020
    Institution name：新潟大学

  • 基礎科学演習

    2016
    Institution name：新潟大学

  • 生体機能学

    2015
    -
    2020
    Institution name：新潟大学

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Social Activities

  • 食から目指す健康寿命の延伸－「食べる力」は「生きる力」米発酵食品でストレスを解消する

    Role(s)： Lecturer

    新潟大学  令和５年度後期 新潟大学公開講座 (新潟市）  2023.10

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  • 食から目指す健康寿命の延伸－「食べる力」は「生きる力」米由来食品でストレスを解消する

    Role(s)： Lecturer

    令和４年度後期 新潟大学公開講座 (新潟市）  2022.11

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  • 百薬の長「日本酒」のヒミツ

    Role(s)： Lecturer

    令和４年度 「そのき市民学級 人生百年時代 賢く生きる」  2022.10

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  • 新潟大学 日本酒学体験講座 (@文部科学省)

    Role(s)： Lecturer,　Organizing member

    日本酒学ことはじめ 日本酒と健康  2019.12

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  • 新潟大学 市民公開講座（新潟市）

    Role(s)： Lecturer,　Organizing member

    新潟大学  日本酒学ことはじめ 日本酒と健康  2018.12

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  • 明倫短期大学 非常勤講師

    Role(s)： Lecturer

    2016.4

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Media Coverage

  • 古来からの知恵「米麹」のチカラを毎日のごはんに取り入れ、健やかに Internet

    「ソラミドごはん」 スカイベイビーズ  https://gohan.soramido.com/magazine/komekouji  2025.1

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    Author：Other 

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  • 米麹がストレス軽減につながる？米発酵食品の健康効果について聞いた Internet

    メディアエンジン株式会社  Wellulu  https://wellulu.com/balanced-diet/12241/  2023.12

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    Author：Other 

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  • 米麹にストレス軽減効果 Newspaper, magazine

    新潟日報  社会面  2023.11

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    Author：Other 

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  • Niigata University reveals that Rice-koji is effective in alleviating stress in mice: Suppression of anxiety and pain Newspaper, magazine

    JST  https://sj.jst.go.jp/news/202312/n1214-04k.html  2023.11

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    Author：Other 

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