Faculty Profiles - FUJIHARA Kazuya

MISC - FUJIHARA Kazuya

Division display 341 - 360 of about 387 ／ All the affair displays >>

異なる空腹時血糖値異常とHbA1c高値の判定基準を用いた2型糖尿病予測スクリーニング精度の比較:TOPICS

平安座依子, 原茂子, 謝勲東, 児玉暁, 辻裕之, 藤原和哉, 由澤咲子, 伊部陽子, 齋藤和美, 山田信博, 荒瀬康司, 曽根博仁

Journal of Epidemiology 22 ( Supplement 1 ) 122 2012.1

2型糖尿病発症10年間のHbA1c値の変化:TOPICS

平安座依子, 荒瀬康司, 辻裕之, 齋藤和美, 藤原和哉, 謝勲東, 児玉暁, 山田信博, 原茂子, 曽根博仁

Journal of Epidemiology 22 ( Supplement 1 ) 122 2012.1

HbA1cを導入した新しい2型糖尿病予測スコアリングシステムの開発

平安座依子, 謝勲東, 原茂子, 辻裕之, 藤原和哉, 堀川千嘉, 谷内洋子, 児玉暁, 山田信博, 荒瀬康司, 曽根博仁

日本成人病(生活習慣病)学会会誌 38 54 - 54 2012.1

2型糖尿病発症前のHbA1c値と空腹時血糖値の変化に関する大規模縦断的検討

平安座依子, 荒瀬康司, 辻裕之, 齋藤和美, 藤原和哉, 謝勲東, 児玉暁, 山田信博, 原茂子, 曽根博仁

日本成人病(生活習慣病)学会会誌 38 53 2012.1

糖尿病性ケトアシドーシスに併発した肺アスペルギルス症の1例

藤田英理子, 黒澤陽一, 濱田治, 尾本美代子, 藤原和哉, 大原原, 籠橋克紀, 栗島浩一, 曽根博仁, 佐藤浩昭

日本内科学会関東支部関東地方会 588th 36 2012

尿路結石による水腎症および無機能腎を呈し,同側腎からの高レニン血症により二次性高血圧を来たした1例

五十野桃子, 藤原和哉, 鈴木智晴, 五十野博基, 志鎌明人, 宜保英彦, 尾本美代子, 曽根博仁

日本内分泌学会関東甲信越支部学術集会プログラム抄録集 13th 52 2012

原発性高脂血症に関する調査研究 2型糖尿病患者の冠動脈病変予測と脂質異常

島野仁, 鈴木浩明, 藤原和哉, 佐藤明, 曽根博仁

原発性高脂血症に関する調査研究平成23年度総括研究報告書 54 - 62 2012

Fasting and Post-Challenge Glucose as Quantitative Cardiovascular Risk Factors: A Meta-Analysis

Satoru Kodama, Kazumi Saito, Shiro Tanaka, Chika Horikawa, Kazuya Fujiwara, Reiko Hirasawa, Yoko Yachi, Yasuko Sone, Kaoruko Tada Iida, Hitoshi Shimano, Yasuo Ohashi, Nobuhiro Yamada, Hirohito Sone

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 19 ( 4 ) 385 - 396 2012

Language：English Publisher：JAPAN ATHEROSCLEROSIS SOC

Aim: The post-challenge glucose (PCG) level has been suggested to be superior to the fasting blood glucose (FG) level for predicting the risk of future cardiovascular disease (CVD); however, the extent of its superiority has not been consistently shown among previous cohort studies. Therefore, we conducted a meta-analysis to summarize the quantitative association of FG and PCG with CVD risk and compared the strengths of the two associations.
Method: Electronic literature searches using MEDLINE and EMBASE with an additional manual search were conducted for prospective observational studies of the association of FG and PCG with CVD risk. Studies were included if they were prospective studies in which the relative risk (RR) of CVD per 1 standard deviation increase in both FG and PCG could be estimated. Pooled relative risks for the incremental increase were calculated as RRFG and RRPCG using a bivariate random-effects model.
Result: Data were obtained from 14 eligible studies that included 70,889 participants and 2,927 cases. The pooled RRFG and RRPCG (95% confidence interval) were, respectively, 1.15 (1.06 to 1.26) and 1.24 (1.12 to 1.36); the difference was significant (P = 0.001). The association of PCG with CVD risk was stronger in studies that targeted participants with a baseline mean FG <100 mg/dl (P < 0.001) or mean age >= 55 years (P = 0.004).
Conclusions: Overall, the association of PCG with CVD risk was stronger than that of FG by approximately 50% on a log scale. Measuring PCG is especially important in populations with relatively low FG levels or in the elderly, although it is often burdensome in routine clinical practice.

DOI： 10.5551/jat.10975

Web of Science

researchmap

横紋筋融解症,急性心筋炎から救命しえた劇症1型糖尿病の1例

宜保英彦, 藤原和哉, 小林和人, 高橋昭光, 矢藤繁, 鈴木浩明, 島野仁, 山田信博, 曽根博仁

日本内分泌学会雑誌 87 ( 3 ) 963 2011.12

震災時の精神的ストレスが血糖に与える影響

藤原和哉, 宜保英彦, 小林和人, 高橋昭光, 矢藤繁, 鈴木浩明, 山田信博, 斎藤和美, 曽根博仁

日本内分泌学会雑誌 87 ( 3 ) 1005 2011.12

胴身長比(Waist‐to‐stature ratio:WSR)と2型糖尿病発症(T2DM)との関連性のメタ解析

児玉暁, 堀川千嘉, 平安座依子, 斎藤あき, 菅原歩美, 谷内洋子, 平澤玲子, 藤原和哉, 斎藤和美, 曽根博仁

肥満研究 17 ( Suppl. ) 166 - 166 2011.9

動脈硬化リスク因子のupdate 糖尿病・耐糖能異常

藤原和哉, 曽根博仁

循環器内科 70 ( 2 ) 148 - 156 2011.8

HbA(1c) 5.7-6.4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study

Yoriko Heianza, Shigeko Hara, Yasuji Arase, Kazumi Saito, Kazuya Fujiwara, Hiroshi Tsuji, Satoru Kodama, Shiun Dong Hsieh, Yasumichi Mori, Hitoshi Shimano, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

LANCET 378 ( 9786 ) 147 - 155 2011.7

Language：English Publisher：ELSEVIER SCIENCE INC

Background The clinical relevance of the diagnostic criteria for prediabetes to prediction of progression to diabetes has been little studied. We aimed to compare the prevalence of prediabetes when assessed by the new glycated haemoglobin A(1c) (HbA(1c)) 5.7-6.4% criterion or by impaired fasting glucose, and assessed differences in progression rate to diabetes between these two criteria for prediabetes in a Japanese population.
Methods Our longitudinal cohort study included 4670 men and 1571 women aged 24-82 years without diabetes at baseline (diabetes was defined as fasting plasma glucose >= 7.0 mmol/L, self-reported clinician-diagnosed diabetes, or HbA(1c) >= 6.5%) who attended Toranomon Hospital (Tokyo, Japan) for a routine health check between 1997 and 2003. Participants with a baseline diagnosis of prediabetes according to impaired fasting glucose (fasting plasma glucose 5.6-6.9 mmol/L) or HbA(1c) 5.7-6.4%, or both, were divided into four groups on the basis of baseline diagnosis of prediabetes. Rate of progression to diabetes was assessed annually.
Findings Mean follow-up was 4.7 (SD 0.7) years. 412 (7%) of 6241 participants were diagnosed with prediabetes on the basis of the HbA(1c) 5.7-6.4% criterion. Screening by HbA(1c) alone missed 1270 (61%) of the 2092 prediabetic individuals diagnosed by a combination of impaired fasting glucose and HbA(1c) 5.7-6.4%. Overall cumulative probability of progression to diabetes did not differ significantly between participants with prediabetes discordantly diagnosed by either HbA(1c) or impaired fasting glucose alone (incidence was 7% for HbA(1c) alone [n=412 individuals and 30 incident cases] and 9% for impaired fasting glucose alone [n=1270,108 cases]; log-rank test, p=0.3317). Multivariate-adjusted hazard ratios for incident diabetes were 6.16 (95% CI 4.33-8.77) for those diagnosed with prediabetes by impaired fasting glucose alone and 6.00 (3.76-9.56) for diagnosis by HbA(1c) alone, and were substantially increased to 31.9 (22.6-45.0) for diagnosis by both impaired fasting glucose and HbA(1c) compared with normoglycaemic individuals.
Interpretation Diagnosis of prediabetes by both the new HbA(1c) criterion and impaired fasting glucose identified individuals with an increased risk of progression to diabetes. Although the new HbA(1c) criterion identified fewer individuals at high risk than did impaired fasting glucose, the predictive value for progression to diabetes assessed by HbA(1c) 5.7-6.4% was similar to that assessed by impaired fasting glucose alone. The two tests used together could efficiently target people who are most likely to develop diabetes and allow for early intervention.

DOI： 10.1016/S0140-6736(11)60472-8

Web of Science

PubMed

researchmap

動脈硬化症と脂質異常症の理解のために【動脈硬化症発症に及ぼす各危険因子の影響】糖尿病が果たす役割

藤原和哉, 曽根博仁

Medicina 48 ( 5 ) 734 - 738 2011.5