Updated on 2021/12/04

写真a

 
EGUCHI Kaori
 
Organization
University Medical and Dental Hospital Prosthodontics and Oral Function Fixed Prosthodontics Assistant Professor
Title
Assistant Professor
External link

Degree

  • 博士(歯学) ( 2016.3   新潟大学 )

Research Interests

  • 歯学教育

  • 歯科補綴学

  • 骨代謝

  • 金属アレルギー

Research Areas

  • Life Science / Prosthodontics

  • Life Science / Oral biological science

Research History (researchmap)

  • Niigata University   Medical and Dental Hospital   Assistant Professor

    2017.4

      More details

  • Niigata University   Medical and Dental Hospital

    2016.4 - 2017.3

      More details

Research History

  • Niigata University   University Medical and Dental Hospital Occlusal Function Fixed Prosthodontics   Assistant Professor

    2017.4

Education

  • Niigata University   Graduate School of Medical and Dental Sciences

    2012.4 - 2016.3

      More details

  • Niigata University   Faculty of Dentistry   School of Dentistry

    2005.4 - 2011.3

      More details

Professional Memberships

 

Papers

  • The relationship between dental metal allergy, periodontitis, and palmoplantar pustulosis: An observational study.

    Yurina Takaoka, Yosuke Akiba, Masako Nagasawa, Akiko Ito, Yukiko Masui, Nami Akiba, Kaori Eguchi, Haruna Miyazawa, Koichi Tabeta, Katsumi Uoshima

    Journal of prosthodontic research   2021.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: This study aimed to investigate the relationship between dental metal allergy, periodontitis, and palmoplantar pustulosis among patients from a dental metal allergy clinic over a period of 8 years. METHODS: This study included 436 patients who visited our dental metal allergy clinic between April 1, 2009 and March 31, 2016. Diagnoses of skin diseases, periodontal records, dental metal series patch test results, and electron probe microanalysis (EPMA) data were obtained from medical records. Relative risk (RR) values were estimated from these data. RESULTS: Of the 359 patients who underwent the patch test, 241 showed a positive reaction. Of the 187 patients who underwent EPMA, 113 had allergenic metals in their dental prostheses. These patients were suspected to have a dental metal allergy. Furthermore, 150 of the 436 patients were diagnosed with palmoplantar pustulosis (PPP). The RR of metal allergy between patients with PPP and healthy subjects was 3.88. The RR of periodontal disease between patients with PPP and PPP-negative patients in the national average was 2.54. CONCLUSIONS: In this study, both dental metal allergy and periodontitis showed a high RR for PPP.

    DOI: 10.2186/jpr.JPR_D_20_00307

    PubMed

    researchmap

  • Biological reaction control using topography regulation of nanostructured titanium Reviewed International journal

    Mayuko Shiozawa, Haruka Takeuchi, Yosuke Akiba, Kaori Eguchi, Nami Akiba, Yujin Aoyagi, Masako Nagasawa, Hiroyuki Kuwae, Kenji Izumi, Katsumi Uoshima, Jun Mizuno

    Scientific Reports   10 ( 1 )   2438 - 2438   2020.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    © 2020, The Author(s). The micro- and nanosize surface topography of dental implants has been shown to affect the growth of surrounding cells. In this study, standardized and controlled periodic nanopatterns were fabricated with nanosized surface roughness on titanium substrates, and their influence on bone marrow stromal cells investigated. Cell proliferation assays revealed that the bare substrate with a 1.7 nm surface roughness has lower hydrophilicity but higher proliferation ability than that with a 0.6 nm surface roughness. Further, with the latter substrate, directional cell growth was observed for line and groove patterns with a width of 100 nm and a height of 50 or 100 nm, but not for those with a height of 10 or 25 nm. With the smooth substrate, time-lapse microscopic analyses showed that more than 80% of the bone marrow cells on the line and groove pattern with a height of 100 nm grew and divided along the lines. As the nanosized grain structure controls the cell proliferation rate and the nanosized line and groove structure (50–100 nm) controls cell migration, division, and growth orientation, these standardized nanosized titanium structures can be used to elucidate the mechanisms by which surface topography regulates tissue responses to biomaterials.

    DOI: 10.1038/s41598-020-59395-4

    Scopus

    PubMed

    researchmap

  • バーチャルリアリティ(VR)とオーグメンテッドリアリティ(AR)を用いた支台歯形成練習の効果

    長澤 麻沙子, 秋葉 奈美, 江口 香里, 高 昇将, 魚島 勝美

    日本歯科医学教育学会総会・学術大会プログラム・抄録集   39回   62 - 62   2020.9

     More details

    Language:Japanese   Publisher:(一社)日本歯科医学教育学会  

    researchmap

  • ROCK inhibitors enhance bone healing by promoting osteoclastic and osteoblastic differentiation Reviewed International journal

    Juri Nakata, Yosuke Akiba, Jun Nihara, Lay Thant, Kaori Eguchi, Hiroko Kato, Kenji Izumi, Mariko Ohkura, Masanori Otake, Yoshito Kakihara, Isao Saito, Makio Saeki

    Biochemical and Biophysical Research Communications   526 ( 3 )   547 - 552   2020

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    © 2020 Elsevier Inc. Osteoclast and osteoblast are essential for proper bone development and remodeling as well as recovery of bone fracture. In this study, we seek chemical compounds that enhance turnover of bone metabolism for promoting bone healing. First, we screen a chemical library which includes 378 compounds by using murine pre-osteoclastic RAW264.7 cells to identify compounds that promote osteoclastic differentiation. We find that two ROCK (Rho-associated coiled-coil kinase) inhibitors, HA-1077 (Fasudil) and Y-27632, enhance osteoclastogenesis. Subsequently, we identify that these two compounds also increase osteoblastic differentiation of MC3T3-E1 cells. Finally, our in vivo experiment shows that the local administration of ROCK inhibitors accelerate the bone healing of the rat calvarial defect.

    DOI: 10.1016/j.bbrc.2020.03.033

    Scopus

    PubMed

    researchmap

  • Valproic Acid Contributes to Bone Cavity Healing in Rats Reviewed

    Mamunur Rashid, Yosuke Akiba, Kaori Eguchi, Nami Akiba, Masaru Kaku, Masako Nagasawa, Katsumi Uoshima

    9 ( 3 )   1 - 8   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    File: valproic-acid-contributes-to-bone-cavity-healing-in-rats.pdf

    researchmap

  • Insulin-like growth factor binding Protein-3 suppresses osteoblast differentiation via bone morphogenetic protein-2. Reviewed International journal

    Kaori Eguchi, Yosuke Akiba, Nami Akiba, Masako Nagasawa, Lyndon F Cooper, Katsumi Uoshima

    Biochemical and biophysical research communications   507 ( 1-4 )   465 - 470   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Bone augmentation therapy is used in dental implantation. While techniques to induce bone formation are generally successful, the maintenance of bone mass is more difficult. Therefore, it is important to understand the mechanisms that regulate this process. Insulin-like growth factor-1 (IGF-1) is one of the most abundant growth factors that regulate bone mass, promote osteoblast differentiation, and accelerate bone formation. The activity of IGF-1 is regulated by IGF-binding proteins (IGFBPs). IGFBP-3 forms a ternary complex with IGF-1, extending its half-life in the circulating system. Therefore, IGFBP-3 acts as a stabilizer and transporter of IGF-1. Recent studies reported new IGF-1-independent functions of IGFBP-3 related with bone metabolism. In this study, we investigated the function of IGFBP-3 in osteoblast differentiation. Our results showed that IGFBP-3 decreases the expression of osteoblast differentiation markers, whose expression is enhanced by bone morphogenetic protein-2 (BMP-2). IGFBP-3 also reduced BMP-2 effect on ALP activity and mineral nodule formation. In addition, IGFBP-3 suppresses the activity of the Smad Binding Element (SBE) reporter, induced by BMP-2 signaling. These results suggest that IGFBP-3 inhibits osteoblast differentiation through the BMP-2 signal pathway, and that IGFBP-3 might play a role in bone mass maintenance in an IGF-1-dependent and -independent manner.

    DOI: 10.1016/j.bbrc.2018.11.065

    PubMed

    researchmap

  • The effect of ROCK inhibitor on bone remodeling Reviewed

    Juri Nakata, Yosuke Akiba, Kaori Eguchi, Jun Nihara, Isao Saito, Yoshito Kakihara, Makio Saeki

    JOURNAL OF BONE AND MINERAL RESEARCH   32   S229 - S229   2017.12

     More details

    Language:English   Publisher:WILEY  

    Web of Science

    researchmap

  • Biological Evaluation of Implant Drill Made from Zirconium Dioxide. Reviewed International journal

    Yosuke Akiba, Kaori Eguchi, Nami Akiba, Katsumi Uoshima

    Clinical implant dentistry and related research   19 ( 2 )   306 - 315   2017.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: Zirconia is a good candidate material in the dental field. In this study, we evaluated biological responses against a zirconia drill using a bone cavity healing model. MATERIALS AND METHODS: Zirconia drills, stainless steel drills, and the drilled bone surface were observed by scanning electron microscopy (SEM), before and after cavity preparation. For the bone cavity healing model, the upper first and second molars of Wistar rats were extracted. After 4 weeks, cavities were prepared with zirconia drills on the left side. As a control, a stainless steel drill was used on the right side. At 3, 7, and 14 days after surgery, micro-CT images were taken. Samples were prepared for histological staining. RESULTS: SEM images revealed that zirconia drills maintained sharpness even after 30 drilling procedures. The bone surface was smoother with the zirconia drill. Micro-CT images showed faster and earlier bone healing in the zirconia drill cavity. On H-E staining, at 7 days, the zirconia drill defect had a smaller blank lacunae area. At 14 days, the zirconia drill defect was filled with newly formed bone. CONCLUSIONS: The zirconia drill induces less damage during cavity preparation and is advantageous for bone healing. (197 words).

    DOI: 10.1111/cid.12452

    PubMed

    researchmap

  • ヒストン脱アセチル化酵素阻害剤(HDACI)を用いたエピジェネティクス制御による細胞分化制御を利用した新規骨増成法に関する研究

    秋葉 陽介, 江口 香里, Rashid Md. Mamunur, 加来 賢, 秋葉 奈美, 魚島 勝美

    日本歯科医学会誌   33   44 - 48   2014.3

     More details

    Language:Japanese   Publisher:日本歯科医学会  

    ヒストン脱アセチル化酵素阻害剤(HDACI)は抗癌剤、抗てんかん薬として臨床応用される薬剤である。HDACIは遺伝子発現過程においてクロマチンリモデリングに関与し、遺伝子発現を活性化することが知られている。骨形成関連においてはRunx2の安定化に関与し骨芽細胞の分化を促進する作用が報告されている。そこで本研究では、はじめに上顎骨円筒形骨欠損修復モデルを用いてHDACIの全身投与における骨形成能の賦活化を検討することとした。HDACIにはバルプロ酸(Valproic acid(VPA))を使用し、投与法は腹腔内投与、投与期間は円筒形骨欠損形成前7日間とした。VPA全身投与群では窩洞内新生骨形成能促進、円筒形骨欠損治癒促進を示す像が窩洞形成14日から21日後にかけて観察された。次に頭蓋骨限界径骨欠損細胞移植モデルを作製し、大腿骨より採取した骨髄間質細胞をVPA処理し欠損部へ移植した。VPA処理細胞移植窩洞では対照群と比較して窩洞内の石灰化の亢進が観察された。本研究より骨増成法におけるHDACIの有効性が示され、更にHDACIの多機能性を応用した新規骨増成法開発の可能性が示唆された。(著者抄録)

    researchmap

▶ display all

MISC

  • 本学歯学部学生の歯冠修復学実習における支台歯形成自己評価能力について

    長澤麻沙子, 秋葉奈美, 秋葉陽介, 加来賢, 青柳裕仁, ROCABADO J, M Rosales, 江口香里, 魚島勝美

    日本歯科医学教育学会総会・学術大会プログラム・抄録集   38th   94   2019.6

     More details

    Language:Japanese  

    J-GLOBAL

    researchmap

  • 乾癬の病態機構に対する歯科金属アレルギー関与の可能性の探究

    高岡 由梨那, 秋葉 陽介, 秋葉 奈美, 長澤 麻沙子, 江口 香里, 竹内 陽香, 魚島 勝美

    日本歯科医学会誌   38   59 - 59   2019.3

     More details

    Language:Japanese   Publisher:日本歯科医学会  

    researchmap

  • ROCK阻害剤の骨代謝および矯正学的歯の移動への影響

    中田 樹里, 柿原 嘉人, 秋葉 陽介, 江口 香里, 丹原 惇, 大倉 麻里子, 加藤 寛子, 泉 健次, 佐伯 万騎男, 齋藤 功

    新潟歯学会雑誌   47 ( 2 )   120 - 120   2017.12

     More details

    Language:Japanese   Publisher:新潟歯学会  

    researchmap

  • 明倫短期大学附属歯科診療所における訪問歯科診療の実態調査(第二報) 患者側からみた歯科訪問診療の評価

    小林 梢, 河野 雅之, 加藤 由香里, 廣安 和枝, 井田 貴子, 江口 香里, 宮 福子, 市川 伸彦, 水橋 庸子, 春川 麻美, 鈴木 紗都子, 涌井 英恵, 椎谷 恵, 五十嵐 有沙, 八幡 可奈子, 小林 智美, 牧野 真理, 白井 貴美, 木暮 ミカ

    明倫短期大学紀要   20 ( 1 )   132 - 132   2017.7

     More details

    Language:Japanese   Publisher:明倫短期大学  

    researchmap

  • ROCK阻害剤の骨代謝への影響とその作用機序の解析

    中田 樹里, 秋葉 陽介, 江口 香里, 丹原 惇, 齋藤 功, 柿原 嘉人, 佐伯 万騎男

    日本骨代謝学会学術集会プログラム抄録集   35回   184 - 184   2017.7

     More details

    Language:Japanese   Publisher:(一社)日本骨代謝学会  

    researchmap

  • 明倫短期大学附属歯科診療所における訪問歯科診療の実態調査(第一報) 訪問件数の動向

    市川 伸彦, 河野 雅之, 加藤 由香里, 廣安 和枝, 井田 貴子, 江口 香里, 宮 福子, 小林 梢, 水橋 庸子, 春川 麻美, 鈴木 紗都子, 涌井 英恵, 椎谷 恵, 五十嵐 有沙, 八幡 可奈子, 小林 智美, 牧野 真理, 白井 貴美, 赤川 貴行, 森田 知治, 木暮 ミカ

    明倫短期大学紀要   20 ( 1 )   131 - 131   2017.7

     More details

    Language:Japanese   Publisher:明倫短期大学  

    researchmap

  • IGFBP-3はBMP-2シグナルを介してIGF非依存的に骨形成を抑制する

    江口 香里, 秋葉 陽介, 秋葉 奈美, 長澤 麻沙子, Cooper Lyndon, 魚島 勝美

    日本補綴歯科学会誌   8 ( 特別号 )   259 - 259   2016.7

     More details

    Language:Japanese   Publisher:(公社)日本補綴歯科学会  

    researchmap

  • 機能特化プライミング細胞カクテルによる多面的骨形成法

    秋葉 陽介, 江口 香里, 秋葉 奈美, 魚島 勝美

    日本補綴歯科学会誌   8 ( 特別号 )   151 - 151   2016.7

     More details

    Language:Japanese   Publisher:(公社)日本補綴歯科学会  

    researchmap

  • IGFBP-3はBMP-2シグナルを介してIGF非依存的に骨形成を抑制する

    江口香里, 秋葉陽介, 秋葉奈美, 長澤麻沙子, COOPER Lyndon, 魚島勝美

    日本補綴歯科学会誌(Web)   8   2016

  • 機能特化プライミング細胞カクテルによる多面的骨形成法

    秋葉陽介, 江口香里, 秋葉奈美, 魚島勝美

    日本補綴歯科学会誌(Web)   8   2016

  • IGF binding protein 3はBMP 2シグナルを介してIGF非依存的に骨形成を抑制する

    江口 香里, 秋葉 陽介, 長澤 麻沙子, 水嶌 一尊, クーパー・リンドン, 魚島 勝美

    新潟歯学会雑誌   45 ( 2 )   107 - 107   2015.12

     More details

    Language:Japanese   Publisher:新潟歯学会  

    researchmap

  • 多機能性エピジェネティクス化合物による骨増成法への多面的アプローチ

    秋葉 陽介, 江口 香里, 秋葉 奈美, 北見 恩美, マルセロ・ロサレス, 加来 賢, 魚島 勝美

    日本補綴歯科学会誌   6 ( 特別号 )   264 - 264   2014.5

     More details

    Language:Japanese   Publisher:(公社)日本補綴歯科学会  

    researchmap

  • HDACi処理細胞移植による骨増成法の検討

    江口 香里, 秋葉 陽介, 秋葉 奈美, 北見 恩美, 加来 賢, 魚島 勝美

    Journal of Oral Biosciences Supplement   2013   189 - 189   2013.9

     More details

    Language:Japanese   Publisher:(一社)歯科基礎医学会  

    researchmap

  • ジルコニア製インプラントドリルの生物学的評価に関する研究

    秋葉 陽介, 江口 香里, 秋葉 奈美, Rosales Juan Marcelo, 野澤 恩美, 加来 賢, 魚島 勝美

    日本補綴歯科学会誌   5 ( 特別号 )   167 - 167   2013.5

     More details

    Language:Japanese   Publisher:(公社)日本補綴歯科学会  

    researchmap

  • 各種HDACiが骨分化能、骨形成能に与える影響に関する研究

    江口 香里, 秋葉 奈美, Rosales Juan Marcelo, 野澤 恩美, 加来 賢, 秋葉 陽介, 魚島 勝美

    日本補綴歯科学会誌   5 ( 特別号 )   275 - 275   2013.5

     More details

    Language:Japanese   Publisher:(公社)日本補綴歯科学会  

    researchmap

  • HDACi処理細胞移植による骨増成法の検討

    江口香里, 秋葉陽介, 秋葉陽介, 秋葉奈美, 秋葉奈美, 北見恩美, 北見恩美, 加来賢, 魚島勝美, 魚島勝美

    Journal of Oral Biosciences Supplement (Web)   2013   2013

▶ display all

Research Projects

  • IGFBP-3による骨代謝制御機構の解明と新規骨増生法開発への応用

    2017.4 - 2020.3

    日本学術振興会  若手研究(B) 

    江口 香里

      More details

    Authorship:Principal investigator  Grant type:Competitive

    researchmap

  • IGFBP-3を起点とする骨代謝制御を介した新規骨増生法開発

    2016.4 - 2018.3

    日本学術振興会  研究活動スタート支援 

    江口 香里

      More details

    Authorship:Principal investigator  Grant type:Competitive

    researchmap

 

Teaching Experience

  • 歯科臨床推論

    2021
    Institution name:新潟大学

  • 歯科衛生士臨床実習II

    2021
    Institution name:新潟大学

  • 早期臨床実習Ⅱ

    2020
    Institution name:新潟大学

  • 歯の形態学

    2020
    Institution name:新潟大学

  • 特別授業 歯科臨床推論

    2020
    Institution name:新潟大学