2024/12/22 更新

写真a

ミウラ　シオリ
三浦　詩織
MIURA Shiori
所属
研究統括機構 研究倫理・リスク管理部門 特任助教
職名
特任助教
外部リンク

学位

  • 博士 (農学) （ 2017年3月   岐阜大学 ）

研究キーワード

  • バイオセーフティ

  • バイオリスクマネジメント

  • 移植学

  • 実験動物学

  • 遺伝子発現解析

研究分野

  • ライフサイエンス / 実験動物学

  • ライフサイエンス / 分子生物学

経歴（researchmap）

  • 新潟大学   研究統括機構   特任助教

    2024年10月 - 現在

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  • 新潟大学   研究統括機構   特任助教

    2020年7月 - 現在

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  • 新潟大学   脳研究所 生命科学リソース研究センター   特任助手

    2017年10月 - 2020年6月

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  • 鹿児島大学   臓器置換・異種移植外科分野

    2012年 - 2015年

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  • 株式会社しか屋   バイオ事業部

    2010年 - 2012年

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経歴

  • 新潟大学   研究統括機構 研究倫理・リスク管理部門   特任助教

    2024年1月 - 現在

  • 新潟大学   研究推進機構   特任助教

    2020年7月 - 2022年3月

  • 新潟大学   脳研究所　生命科学リソース研究センター   特任助手

    2020年5月 - 2020年6月

  • 新潟大学   脳研究所　生命科学リソース研究センター   特任助手

    2017年10月 - 2020年5月

学歴

  • 岐阜大学   農学研究科   生物資源科学専攻

    - 2017年3月

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    国名： 日本国

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論文

  • Production of marmoset eggs and embryos from xenotransplanted ovary tissues

    Runa Hirayama, Hiroaki Taketsuru, Ena Nakatsukasa, Rie Natsume, Nae Saito, Shuko Adachi, Sayaka Kuwabara, Jun Miyamoto, Shiori Miura, Nobuyoshi Fujisawa, Yoshitaka Maeda, Keizo Takao, Manabu Abe, Toshikuni Sasaoka, Kenji Sakimura

    Scientific Reports   13 ( 1 )   2023年10月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

    Abstract

    The common marmoset (Callithrix jacchus) has attracted attention as a valuable primate model for the analysis of human diseases. Despite the potential for primate genetic modification, however, its widespread lab usage has been limited due to the requirement for a large number of eggs. To make up for traditional oocyte retrieval methods such as hormone administration and surgical techniques, we carried out an alternative approach by utilizing ovarian tissue from deceased marmosets that had been disposed of. This ovarian tissue contains oocytes and can be used as a valuable source of follicles and oocytes. In this approach, the ovarian tissue sections were transplanted under the renal capsules of immunodeficient mice first. Subsequent steps consist of development of follicles by hormone administrations, induction of oocyte maturation and fertilization, and culture of the embryo. This method was first established with rat ovaries, then applied to marmoset ovaries, ultimately resulting in the successful acquisition of the late-stage marmoset embryos. This approach has the potential to contribute to advancements in genetic modification research and disease modeling through the use of primate models, promoting biotechnology with non-human primates and the 3Rs principle in animal experimentation.

    DOI： 10.1038/s41598-023-45224-x

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    その他リンク： https://www.nature.com/articles/s41598-023-45224-x

  • Establishment of a Long-Term Survival Swine Model for the Observation of Transplanted Islets: a Preliminary Step in an Allogeneic Transplant Experiment 国際誌

    Kohei Miura, Takashi Kobayashi, Zhengkun Zhang, Pankaj Prasoon, Yuki Hirose, Hirosuke Ishikawa, Kazuyasu Takizawa, Jun Sakata, Shiori Miura, Toshikuni Sasaoka, Toshifumi Wakai

    Transplantation Proceedings   54 ( 2 )   507 - 512   2022年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    BACKGROUND: Evaluation of an experimental and preclinical islet transplantation (IsletTx) model to elucidate associated clinical problems is vital. This study aimed to introduce a simple methodology for producing a swine autologous IsletTx model as a preliminary step in an allogeneic transplant experiment. METHODS AND MATERIALS: Twenty-seven pigs were included in the study. Total pancreatectomy (TP) was performed in 8 pigs (TP group), TP with autologous IsletTx in 9 (TP + IsletTx group), and distal pancreatectomy (DP) with autologous IsletTx in 10 (DP + IsletTx group). An open biopsy was performed on all pigs during postoperative day 14 using an infrared imaging (IRI) system. Laboratory data and postoperative survival were analyzed and compared according to the procedures done. RESULTS: Postoperative survival rate was significantly higher in the pigs with autologous IsletTx than in those without (P = .026). There were no significant differences in survival between the TP + IsletTx and DP + IsletTx groups (P = .746). Significant hyperglycemia was not observed in both groups, but the DP + IsletTx group remained relatively stable throughout the postoperative course. There were no differences in serum creatinine, aspartate aminotransferase, and alanine aminotransferase levels between the 2 groups. By selective liver lobe transplantation and administration of the IRI system, localization of the transplanted islets via open biopsy was achieved. CONCLUSIONS: We successfully developed an autologous IsletTx model and an open biopsy system using a swine model. This study will aid in the development of an allogeneic IsletTx experiment that may improve transplantation outcomes.

    DOI： 10.1016/j.transproceed.2021.10.029

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  • Effects of carbon monoxide on early dysfunction and microangiopathy following GalT-KO porcine pulmonary xenotransplantation in cynomolgus monkeys 査読

    Hisashi Sahara, Mitsuhiro Sekijima, Yuichi Ariyoshi, Akihiro Kawai, Kohei Miura, Shiori Waki, Louras Nathan, Yusuke Tomita, Takehiro Iwanaga, Kazuaki Nakano, Hitomi Matsunari, Hiroshi Date, Hiroshi Nagashima, Akira Shimizu, Kazuhiko Yamada

    Xenotransplantation   25 ( 1 )   2018年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Blackwell Publishing Inc.  

    Background: Despite progress in the current genetic manipulation of donor pigs, most non-human primates were lost within a day of receiving porcine lung transplants. We previously reported that carbon monoxide (CO) treatment improved pulmonary function in an allogeneic lung transplant (LTx) model using miniature swine. In this study, we evaluated whether the perioperative treatment with low-dose inhalation of CO has beneficial effects on porcine lung xenografts in cynomolgus monkeys (cynos). Methods: Eight cynos received orthotopic left LTx using either α-1,3-galactosyltransferase knockout (GalT-KO
    n = 2) or GalT-KO with human decay accelerating factor (hDAF) (GalT-KO/hDAF
    n = 6) swine donors. These eight animals were divided into three groups. In Group 1 (n = 2), neither donor nor recipients received CO therapy. In Group 2 (n = 4), donors were treated with inhaled CO for 180-minute. In Group 3 (n = 2), both donors and recipients were treated with CO (donor: 180-minute
    recipient: 360-minute). Concentration of inhaled CO was adjusted based on measured levels of carboxyhemoglobin in the blood (15%-20%). Results: Two recipients survived for 3 days
    75 hours (no-CO) and 80 hours (CO in both the donor and the recipient), respectively. Histology showed less inflammatory cell infiltrates, intravascular thrombi, and hemorrhage in the 80-hour survivor with the CO treatment than the 75-hours non-CO treatment. Anti–non-Gal cytotoxicity levels did not affect the early loss of the grafts. Although CO treatment did not prolong overall xeno lung graft survival, the recipient/donor CO treatment helped to maintain platelet counts and inhibit TNF-α and IL-6 secretion at 2 hours after revascularization of grafts. In addition, lung xenografts that were received recipient/donor CO therapy demonstrated fewer macrophage and neutrophil infiltrates. Infiltrating macrophages as well as alveolar epithelial cells in the CO-treated graft expressed heme oxygenase-1. Conclusion: Although further investigation is required, CO treatment may provide a beneficial strategy for pulmonary xenografts.

    DOI： 10.1111/xen.12359

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  • Evaluation of the physiology of miniature pig fed Shochu distillery waste using mRNA expression profiling 査読

    Shiori Miura, Junko Takahashi, Hitoshi Iwahashi

    Journal of Material Cycles and Waste Management   20 ( 1 )   237 - 244   2018年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Tokyo  

    Shochu distillery waste is the discarded material generated during Shochu production, and it has been used as feed for livestock. In this study, we evaluated the applicability of Shochu distillery waste as a livestock diet. Shochu distillery waste diet was fed to Clawn miniature pigs. At the end of the dietary period, blood samples were collected for biochemical examination and microarray analysis. No significant differences were observed between the control and Shochu distillery waste treatment groups based on physical and biochemical examination. Gene expression patterns were also similar. In addition, gene profiling of these two groups was compared with those of hyperlipidemia and toxicant model groups. Expression profiling of the two groups was different from those of the hyperlipidemia and toxicant model groups. In conclusion, the Shochu distillery waste diet did not affect pig physiology and it is a suitable substitute for standard feed. Moreover, these results promote the potential for microarray analysis use in the evaluation of food safety.

    DOI： 10.1007/s10163-016-0567-z

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  • The role of transcriptomics: physiological equivalence based on gene expression profiles 査読

    Miura S, Himaki T, Takahashi J, Iwahashi H

    Reviews in Agricultural Science   5   21 - 35   2017年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • Development of the Intestinal Transplantation Model With Major Histocompatibility Complex Inbred CLAWN Miniature Swine 査読

    K. Miura, H. Sahara, S. Waki, A. Kawai, M. Sekijima, T. Kobayashi, Z. Zhang, T. Wakai, A. Shimizu, K. Yamada

    TRANSPLANTATION PROCEEDINGS   48 ( 4 )   1315 - 1319   2016年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE INC  

    Background. Clinical intestinal transplantation (Int-Tx) is associated with some problems such as rejection, infection, graft-versus-host disease, and ischemia-reperfusion injury (IRI). To determine mechanisms of rejection as well as to develop treatment strategies for Int-Tx, this study was designed to establish both heterotopic and orthotropic Int-Tx models using major histocompatibility antigen complex (MHC) inbred CLAWN miniature swine.
    Materials and Methods. Eleven CLAWN miniature swine received MHC matched but minor antigen mismatched allogenic intestinal grafts. Four animals received intestinal grafts heterotopically and kept host intestine intact. The remaining 7 animals received intestinal grafts orthotopically and resected host small intestine. Continuous infusion of tacrolimus was given from day 0 for 12 days.
    Results. Heterotopically transplanted small intestine were well perfused after revascularization; however, grafts easily underwent ischemic changes during or soon after abdomen closure due to oppression of the grafts in the limited abdominal space. In contrast, all of 7 orthotopically transplanted intestinal grafts in which recipients' small intestine was removed from the jejunum to the ileum had no signs of severe ischemia associated with compartment syndrome. Elevation of the serum concentration of inflammatory cytokines and the progression of lethal acidosis seen in recipients of heterotipic transplantation were markedly less in the case of orthotopic transplantation. Two recipients survived more than 30 days, and 1 long-term survivor showed no evidence of rejection at day 90 despite the fact that tacrolimus was stopped at day 12.
    Conclusions. In this study, we demonstrated the establishment of a clinically relevant orthotopic Int-Tx model with long survival in MHC inbred CLAWN miniature swine. We believe that this unique MHC inbred swine Int-Tx model is useful for developing treatment strategies for clinical Int-Tx.

    DOI： 10.1016/j.transproceed.2016.01.023

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  • Protective Effect of Neutralization of the Extracellular High-Mobility Group Box 1 on Renal Ischemia-Reperfusion Injury in Miniature Swine 査読

    Kohei Miura, Hisashi Sahara, Mitsuhiro Sekijima, Akihiro Kawai, Shiori Waki, Hiroaki Nishimura, Kentaro Setoyama, Eric S. Clayman, Akira Shimizu, Kazuhiko Yamada

    TRANSPLANTATION   98 ( 9 )   937 - 943   2014年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

    Background Strategies that reduce ischemia-reperfusion injury (IRI) have the potential to expand the numbers of available organs for transplantation. Recent reports in rodent models have demonstrated that high-mobility group box 1 (HMGB1) acts as an alarm in initiating the inflammatory response resulting from ischemic injury. The aim of this study was to evaluate the cytoprotective effects of anti-HMGB1 antibodies on renal IRI in preclinical large animals.
    Methods One hundred twenty minutes of warm and 60 min of cold renal ischemia were induced in 8 CLAWN miniature swine. Three of eight animals received intravenous anti-HMGB1 antibody at 1 mg/kg just before the reperfusion of renal blood flow. Renal function was assessed by serum creatinine and renal biopsy. Serum levels of interleukin (IL)-1, IL-6, and HMGB1 were measured.
    Results The concentration of HMGB1 increased as early as 30 min after reperfusion and before the elevation of IL-1 and IL-6. Serum creatinine levels were markedly elevated, peaking at a median of 5 days (peak creatinine levels: 11.61.6 mg/dL) and recovering by day 14. Anti-HMGB1 antibody injection dramatically decreased renal damage as well as serum levels of HMGB1 associated with IRI. Renal function returned to near normal by day 9, and peak creatinine levels were markedly lower (7.4 +/- 0.2 mg/dL), and biopsies possessed fewer pathologic changes when compared to the control group.
    Conclusion In this study, we demonstrated the beneficial effects of perioperative administration of anti-HMGB1 antibody in reducing renal IRI in a clinically relevant, large animal model.

    DOI： 10.1097/TP.0000000000000358

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  • Results of Life-Supporting Galactosyltransferase Knockout Kidneys in Cynomolgus Monkeys Using Two Different Sources of Galactosyltransferase Knockout Swine 査読

    Mitsuhiro Sekijima, Shiori Waki, Hisashi Sahara, Masayuki Tasaki, Robert A. Wilkinson, Vincenzo Villani, Yoshiki Shimatsu, Kazuaki Nakano, Hitomi Matsunari, Hiroshi Nagashima, Jay A. Fishman, Akira Shimizu, Kazuhiko Yamada

    TRANSPLANTATION   98 ( 4 )   419 - 426   2014年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

    Background. Various durations of survival have been observed in the xenotransplantation of life-supporting alpha-1,3-galactosyltransferase knockout (GalT-KO) porcine kidneys into nonhuman primates. Although others have demonstrated loss of GalT-KOV-transplanted kidneys within 2 weeks, we have reported an average survival of 51 days with the cotransplantation of the kidney and vascularized thymus and an average of 29 days with the kidney alone. To determine the factors responsible for this difference in survival time, we performed xenogeneic kidney transplantations into cynomolgus monkeys with an anti-CD40L/based regimen using two different strains of GalT-KO swine, one derived from MGH miniature swine and the other obtained from Meji University.
    Materials and Methods. Eight cynomolgus moneys received GalT-KO kidneys. Three kidney grafts were from Massachusetts General Hospital (MGH)-Nippon Institute for Biological Science (NIBS) GalT-KO pigs and five GalT-KO grafts were from MEIJI GalT-KO swine. All cynomolgus recipients were treated identically.
    Results. Recipients of kidneys from the MGH GalT-KO kidneys swine, produced by nuclear transfer in Japan, survived an average of 28.7 days, whereas recipients of MEIJI GalT-KO kidneys swine survived an average of 9.2 days. Among the differences between these two groups, one potentially revealing disparity was that the MEIJI swine were positive for porcine cytomegalovirus, whereas the MGH-derived swine were negative.
    Conclusion. This is the first study comparing renal xenotransplantation from two different sources of GalT-KO swine into nonhuman primates at a single center. The results demonstrate that porcine cytomegalovirus may be responsible for early loss of GalT-KO swine kidney xenografts.

    DOI： 10.1097/TP.0000000000000314

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  • Production of cloned NIBS (Nippon Institute for Biological Science) and α-1, 3-galactosyltransferase knockout MGH miniature pigs by somatic cell nuclear transfer using the NIBS breed as surrogates 査読

    Shimatsu Y, Yamada K, Horii W, Hirakata A, Sakamoto Y, Waki (Miura) S, Sano J, Saitoh T, Sahara H, Shimizu A, Yazawa H, Sachs DH, Nunoya T

    Xenotransplantation   20 ( 3 )   157 - 164   2013年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/xen.12031

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  • Oligonucleotide Microarray Analysis of Dietary-Induced Hyperlipidemia Gene Expression Profiles in Miniature Pigs 査読

    Junko Takahashi, Shiori Waki, Rena Matsumoto, Junji Odake, Takayuki Miyaji, Junichi Tottori, Takehiro Iwanaga, Hitoshi Iwahashi

    PLOS ONE   7 ( 5 )   e37581   2012年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PUBLIC LIBRARY SCIENCE  

    Background: Hyperlipidemia animal models have been established, but complete gene expression profiles of the transition from normal lipid levels have not been obtained. Miniature pigs are useful model animals for gene expression studies on dietary-induced hyperlipidemia because they have a similar anatomy and digestive physiology to humans, and blood samples can be obtained from them repeatedly.
    Methodology: Two typical dietary treatments were used for dietary-induced hyperlipidemia models, by using specific pathogen-free (SPF) Clawn miniature pigs. One was a high-fat and high-cholesterol diet (HFCD) and the other was a high-fat, high-cholesterol, and high-sucrose diet (HFCSD). Microarray analyses were conducted from whole blood samples during the dietary period and from white blood cells at the end of the dietary period to evaluate the transition of expression profiles of the two dietary models.
    Principal Findings: Variations in whole blood gene expression intensity within the HFCD or the HFCSD group were in the same range as the controls provide with normal diet at all periods. This indicates uniformity of dietary-induced hyperlipidemia for our dietary protocols. Gene ontology-(GO) based functional analyses revealed that characteristics of the common changes between HFCD and HFCSD were involved in inflammatory responses and reproduction. The correlation coefficient between whole blood and white blood cell expression profiles at 27 weeks with the HFCSD diet was significantly lower than that of the control and HFCD diet groups. This may be due to the effects of RNA originating from the tissues and/or organs.
    Conclusions: No statistically significant differences in fasting plasma lipids and glucose levels between the HFCD and HFCSD groups were observed. However, blood RNA analyses revealed different characteristics corresponding to the dietary protocols. In this study, whole blood RNA analyses proved to be a useful tool to evaluate transitions in dietary-induced hyperlipidemia gene expression profiles in miniature pigs.

    DOI： 10.1371/journal.pone.0037581

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講演・口頭発表等

  • マーモセット卵子をマウス体内で作る～卵巣異種移植の現状と課題～

    三浦 詩織, 平山 瑠那, 竹鶴 裕亮, 中務胞, 夏目理恵, 齊藤奈英, 足立周子, 桑原沙耶香, 宮本純, 藤澤信義, 前田宜俊, 高雄啓三, 阿部学, 崎村建司, 笹岡俊邦

    第26回日本異種移植研究会  2024年2月 

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    開催年月日： 2024年2月

    会議種別：口頭発表（一般）  

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  • 新潟大学における病原体等の適正管理のための体制構築の取り組み

    三浦 詩織, 深見 克哉, 野水 和美, 相馬 恵, 中山 亮, 笹岡 俊邦, 神吉 智丈, 末吉 邦

    第20回日本バイオセーフティ学会総会・学術集会  2021年12月 

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    開催年月日： 2021年12月

    会議種別：口頭発表（一般）  

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  • Generation of functional oocytes of common marmoset by xeno-transplantation of ovarian tissue. 国際会議

    Miura S, Maeda Y, Miyamoto J, Nakatsukasa E, Fujisawa N, Nakamura K, Sakimura K, Sasaoka T

    International symposium on animal production and conservation for sustainable development  2018年10月 

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    記述言語：英語   会議種別：シンポジウム・ワークショップ パネル（公募）  

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  • Efficacious combination of substrate and medium for feeder-free culture of naïve porcine iPS. 国際会議

    Waki (Miura) S, Sahara H, Mitsui K, Sekijima M, Murokawa T, Iwanaga T, Ichinari,Y, Kosai K, Yamada K

    26th International Congress of the Transplantation Society  2016年8月 

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    記述言語：英語   会議種別：ポスター発表  

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  • Establishment of feeder free culture of naive state of porcine iPS cells. 国際会議

    Sahara H, Waki (Miura) S, Mitsui K, Sekijima M, Iwanaga T, Ichinari Y, Kosai K, Yamada K

    IPITA - IXA - CTS 2015 Joint Congress  2015年11月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Development of the intestinal transplantation model with MHC inbred CLAWN miniature swine. 国際会議

    Miura K, Sahara H, Waki (Miura) S, Kawai A, Sekijima M, Wakai T, Shimizu A, Yamada K

    The 14th Congress of the Asian Society of Transplantation.  2015年8月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • MHC-inbred CLAWN miniature swine as preclinical large animal model for transplantation. 国際会議

    Sahara H, Iwanaga T, Sekijima M, Waki (Miura) S, Ichinari Y, Shimizu A, Yamada K

    The 14th Congress of the Asian Society of Transplantation.  2015年8月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Beneficial effects of hydrogen sulfide on reducing ischemia-reperfusion injury and prolonging pulmonary allograft survival of fully MHC-disparate lung in CLAWN miniature swine. 国際会議

    Sahara H, Sekijima M, Ichinari Y, Iwanaga T, Waki (Miura) S, Shimizu A, Yamada K

    The 14th Congress of the Asian Society of Transplantation.  2015年8月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Hydrogen sulfide (H2S) prevents ischemia‐reperfusion injury (IRI) and prolongs survival of the fully MHC‐disparate lung graft in CLAWN miniature swine. 国際会議

    Sahara H, Sekijima M, Waki (Miura) S, Ichinari Y, Shimizu A, Yamada K

    International Society for Heart and Lung Transplantation 35th Annual Meeting.  2015年4月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Carbon monoxide attenuates hyperacute dysfunction and microangiopathy in GalT‐KO pulmonary xenotransplantation. 国際会議

    Sahara H, Nagashima H, Sekijima M, Miura K, Kawai A, Waki (Miura) S, Nakano K, Matsunari H, Date H, Shimizu A, Yamada K

    International Society for Heart and Lung Transplantation 35th Annual Meeting.  2015年4月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Hydrogen sulfide therapy prolongs survival of the fully MHC-disparate lung graft from brain-dead donors in CLAWN miniature swine. 国際会議

    Sahara H, Miura K, Waki (Miura) S, Kawai A, Shimizu A, Yamada K

    World Transplant Congress 2014  2014年7月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Establishment of clinically applicable strategy of CO therapy - Beneficial effects of inhaled carbon monoxide to brain-dead donors on prolonging pulmonary allograft survival in MHC-inbred CLAWN miniature swine. 国際会議

    Sahara H, Miura K, Waki (Miura) S, Kawai A, Shimizu A, Yamada K

    World Transplant Congress 2014  2014年7月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Medical gas (carbon monoxide, hydrogen sulfide) therapy prolongs survival of the fully MHC-disparate lung graft from brain-dead donors in miniature swine. 国際会議

    Sahara H, Miura K, Kawai A, Waki (Miura) S, Shimizu A, Yamada K

    International Society for Heart and Lung Transplantation 34th Annual Meeting.  2014年4月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Attenuation of hyperacute dysfunction and microangiopathy by the treatment of carbon monoxide in GalT-KO pulmonary xenotransplantation. 国際会議

    Sahara H, Nagashima H, Miura K, Waki (Miura) S, Kawai A, Nakano K, Matsunari H, Arai Y, Sekijima M, Tasaki M, Setoyama K, Shimizu A, Date H, Yamada K

    12th Congress IXA (International Xenotransplantation Association 2013)  2013年11月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Results of GalT-KO kidney transplantation in nonhuman primate using two different sources of donors, MGH/Nibs GalT-KO pigs and Meiji GalT-KO pigs at Kagoshima University. 国際会議

    Waki (Miura) S, Sahara H, Miura K, Kawai A, Sekijima M, Tasaki M, Shimizu A, Nakano K, Matsunari H, Arai Y, Nagashima H, Yamada K

    The 2nd Symposium of the East Asia Xenotransplantation Association  2013年11月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Porcine CMV may be the causative agent of porcine kidney rejection in GalT-KO pig to nonhuman primate preclinical xenotransplantation. 国際会議

    Waki (Miura) S, Sahara H, Miura K, Kawai A, Sekijima M, Nakano K, Matsunari H, Arai Y, Tasaki M, Shimizu A, Nagashima H, Yamada K

    12th Congress IXA (International Xenotransplantation Association 2013)  2013年11月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Prolongation of xenogeneic islet function using an HGF-based immunosuppressive regimen in a CLAWN miniature swine-to-cynomolgous monkey model. 国際会議

    Kawai A, Sahara H, Tasaki M, Okitsu T, Oku M, Nishimura H, Sekijima M, Miura K, Waki (Miura) S, Setoyama K, Shimizu A, Yamada K

    he 2nd Symposium of the East Asia Xenotransplantation Association  2013年11月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Porcine CMV may be the causative agent of porcine kidney rejection in GalT-KO pig to nonhuman primate preclinical xenotransplantation. 国際会議

    Waki (Miura) S, Sahara H, Miura K, Kawai A, Tasaki M, Sekijima M, Arai Y, Matsunari H, Nakano K, Shimizu A, Nagashima H, Yamada K

    The 13th Congress of the Asian Society of Transplantation  2013年9月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Potential benefit of subnormothermic preservation for transplanting kidneys which experience extended warm ischemic time in large animal model. 国際会議

    Kawai A, Sahara H, Sekijima M, Miura K, Waki (Miura) S, Shimizu A, Yamada K

    The 13th Congress of the Asian Society of Transplantation  2013年9月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • MHC-inbred CLAWN miniature swine is a highly valuable preclinical model for transplantation and regenerative medicine. 国際会議

    Sahara H, Miura K, Kawai A, Waki (Miura) S, Okumi M, Sekijima M, Tasaki M, Oku M, Nishimura H, Shimizu A, Yamada K

    The 13th Congress of the Asian Society of Transplantation  2013年9月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Beneficial effects of inhaled carbon monoxide (CO) to brain-dead (BD) donors on prolonging pulmonary allograft survival in MHC-inbred CLAWN miniature swine. 国際会議

    Miura K, Sahara H, Waki (Miura) S, Kawai A, Shimizu A, Yamada K

    The 13th Congress of the Asian Society of Transplantation  2013年9月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • Carbon monoxide (CO) inhalation prolongs survival of the fully MHC-disparate lung graft from brain death donors in miniature swine. 国際会議

    Sahara H, Miura K, Kawai A, Waki (Miura) S, Sekijima M, Shimizu A, Yamada K

    International Society for Heart and Lung Transplantation 33rd Annual Meeting  2013年4月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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  • The Effect of Carbon Dioxide to Yeast Saccharomyces cerevisiae. 国際会議

    Waki (Miura) S, Hachisuka Y, Nomura K, Iwahashi H, Matsuoka H, Kawachi S, Suzuki Y, Tamura K

    7th International conference on High Pressure Bioscience and Biotechnology (HPBB2012)  2012年10月 

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    記述言語：英語   会議種別：口頭発表（一般）  

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▶ 全件表示

受賞

  • 優秀演題賞

    2024年2月   第26回日本異種移植研究会  

    三浦 詩織

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  • Best Oral Presentation Award 2013

    2013年   日本異種移植研究会  

    三浦 詩織

    　詳細を見る

  • Young Investigator Travel Award

    2013年   12th Congress IXA (International Xenotransplantation Association 2013)  

    三浦 詩織

    　詳細を見る

  • 岐阜大学連合農学研究科長表彰

    2013年   岐阜大学  

    三浦 詩織

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  • Best Oral Presentation Award

    2012年  

    三浦 詩織

    　詳細を見る

共同研究・競争的資金等の研究

  • 卵巣異種移植の成績を飛躍的に改善するカプセル化卵巣の開発

    研究課題/領域番号：23K15831

    2023年4月 - 2026年3月

    制度名：科学研究費助成事業

    研究種目：若手研究

    提供機関：日本学術振興会

    三浦 詩織

    　 詳細を見る

    配分額：4550000円 （ 直接経費：3500000円 、 間接経費：1050000円 ）

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  • 日本バイオセーフティ学会 海外派遣支援事業

    2023年 - 2024年

    制度名：海外派遣支援事業

    提供機関：日本バイオセーフティ学会

    　 詳細を見る

  • マージナルグラフトに対する移植前臓器保護・機能回復戦略に関する前臨床研究

    研究課題/領域番号：26293355

    2014年4月 - 2017年3月

    制度名：科学研究費助成事業

    研究種目：基盤研究(B)

    提供機関：日本学術振興会

    日下 守, 山田 和彦, 佐原 寿史, 星長 清隆, 三浦 宏平, 河合 彰浩, 脇 詩織

    　 詳細を見る

    配分額：16250000円 （ 直接経費：12500000円 、 間接経費：3750000円 ）

    炎症前駆物質の活性化が組織傷害を惹起するマージナルドナー腎に対し、種々の細胞保護効果を有する薬剤に焦点を当て、詳細な免疫反応評価が可能な組織適合性抗原MHC確立ミニブタを用いた前臨床実験によって、ドナー、レシピエント、グラフト持続灌流保存中への薬物投与による臓器保護・修復効果を検討し、マージナルドナー臓器を生体臓器に匹敵しうる状態に修復・回復する戦略の確立をはかる実験を実施した。

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