Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.7759/cureus.87187

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Publishing type：Research paper (scientific journal)   Publisher：XMLink  

DOI： 10.17245/jdapm.2025.25.3.219

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Other Link： https://jdapm.org/DOIx.php?id=10.17245/jdapm.2025.25.3.219

Publishing type：Research paper (scientific journal)   Publisher：XMLink  

DOI： 10.17245/jdapm.2025.25.3.223

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Other Link： https://jdapm.org/DOIx.php?id=10.17245/jdapm.2025.25.3.223

Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：XMLink  

DOI： 10.17245/jdapm.2025.25.3.215

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Other Link： https://jdapm.org/DOIx.php?id=10.17245/jdapm.2025.25.3.215

Publishing type：Research paper (scientific journal)   Publisher：XMLink  

DOI： 10.17245/jdapm.2025.25.2.139

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Other Link： https://jdapm.org/DOIx.php?id=10.17245/jdapm.2025.25.2.139

Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.7759/cureus.78708

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DOI： 10.7759/cureus.79079

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.heliyon.2024.e41602

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Publishing type：Research paper (scientific journal)   Publisher：XMLink  

DOI： 10.17245/jdapm.2025.25.1.15

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Other Link： https://jdapm.org/DOIx.php?id=10.17245/jdapm.2025.25.1.15

Language：English   Publishing type：Research paper (scientific journal)  

Hemangiomas in the head and neck region, especially those that may impact the airway, require special attention perioperatively because of the potential for difficulties with airway management and bleeding control. This case report describes the management of a 31-year-old male with a large hemangioma of the tongue and pharynx undergoing surgical extraction of mandibular third molars under intubated general anesthesia. Despite taking precautions and avoiding traumatizing the hemangioma while securing the airway, massive bleeding occurred during the surgical extractions, which prompted emergent transfer for angiographic embolization and a stay in the intensive care unit until extubation. This case report highlights the additional attention needed for patients with hemangiomas within the oral cavity and upper airway because of the potential for unexpected massive bleeding that can affect airway management and cardiovascular stability.

DOI： 10.2344/23-0038

PubMed

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Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.7759/cureus.75522

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Publishing type：Research paper (scientific journal)  

DOI： 10.7759/cureus.73784

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Publishing type：Research paper (scientific journal)  

DOI： 10.7759/cureus.70302

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Publishing type：Research paper (scientific journal)   Publisher：XMLink  

DOI： 10.17245/jdapm.2024.24.4.301

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Other Link： https://jdapm.org/DOIx.php?id=10.17245/jdapm.2024.24.4.301

Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

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Publishing type：Research paper (scientific journal)   Publisher：American Dental Society of Anesthesiology (ADSA)  

DOI： 10.2344/23-00043

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Other Link： https://anesthesiaprogress.kglmeridian.com/downloadpdf/journals/anpr/71/1/article-p42.xml

Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

Abstract

Introduction

As the population ages and more patients experience medical emergencies during dental treatments, dentists must competently and confidently manage these situations. We developed a simulation training course for medical emergencies in the dental setting using an inexpensive vital sign simulation app for smartphones/tablets without the need for an expensive simulator. However, the duration for which this effect is maintained is unclear. This study was performed to evaluate the long‐term educational effect at 3, 6, and 12 months after taking the course.

Materials and Methods

Thirty‐nine dental residents participated in this course. Scenarios included vasovagal syncope, anaphylaxis, hyperventilation syndrome, and acute coronary syndrome, each of which the participants had to diagnose and treat. The participants were evaluated using a checklist for anaphylaxis diagnosis and treatment skills immediately after and 3, 6, and 12 months after the course. The participants were also surveyed about their confidence in diagnosing and treating these conditions by questionnaire before, immediately after, and 3, 6, and 12 months after the course.

Results

The checklist scores for anaphylaxis were significantly lower at 3, 6, and 12 months after the course than immediately after the course. The percentage of participants who provided a correct diagnosis and appropriate treatment for vasovagal syncope, hyperventilation syndrome, and acute coronary syndrome was lower at all reassessments than immediately after the course.

Conclusion

Because medical emergency management skills and confidence declined within 3 months, it would be useful to introduce a refresher course approximately 3 months after the initial course to maintain skills and confidence.

DOI： 10.1111/eje.12996

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Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.7759/cureus.52320

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.2344/anpr-70-03-07

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: The impact of the COVID-19 pandemic on dental anesthesiologists has not been examined. This study aimed to determine how the COVID-19 pandemic affected Japanese dental anesthesiologists' professional lives. METHODS: An online questionnaire related to the effects of COVID-19 on dental anesthesiologists' professional lives was emailed to 351 board-certified dental anesthesiology specialists from the Japanese Dental Society of Anesthesiology. The endpoints of this study were changes in income and job satisfaction as a dental anesthesiologist from 2019 prior to the COVID-19 pandemic. RESULTS: A total of 141 dental anesthesiologists participated in the survey. Most respondents reported no change in income relative to 2019 for 2020 or 2021. Significantly more dental anesthesiologists reported income decreases relative to 2019 for 2020 (39%) vs 2021 (21.3%; P = .001). Very few dental anesthesiologists reported income increases relative to 2019 for 2020 (2.1%) vs 2021 (15.6%; P < .001). Job satisfaction as a dental anesthesiologist remained unchanged for all 3 years. CONCLUSION: Even though many Japanese dental anesthesiologist specialists lost income because of COVID-19, they maintained their job satisfaction.

DOI： 10.2344/930714

PubMed

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Publishing type：Research paper (scientific journal)   Publisher：American Dental Society of Anesthesiology (ADSA)  

DOI： 10.2344/anpr-70-03-02

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.jds.2022.08.018

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Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

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Publishing type：Research paper (scientific journal)   Publisher：Cureus, Inc.  

DOI： 10.7759/cureus.33733

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections can cause loss or alteration of taste and smell as early symptoms or sequelae, but the detailed mechanism behind this phenomenon remains unclear. Here, we investigated whether the SARS-CoV-2 spike protein induces taste cell apoptosis and expression of the apoptosis-related cytokine TNF-α in male Sprague-Dawley rats. Terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP)-fluorescein nick end labeling (TUNEL) assay results revealed a significantly higher apoptosis index for taste cells in the SARS-CoV-2 group than for those in the control group. An immunohistochemistry analysis indicated significantly more TNF-α-positive cells in the SARS-CoV-2 group compared with the control group. These data suggest that the SARS-CoV-2 spike protein promotes taste cell apoptosis and the release of apoptosis-related cytokine TNF-α, implicating its contribution to the taste malfunction caused by coronavirus disease 2019 (COVID-19).

DOI： 10.1016/j.jds.2022.08.016

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections cause loss or alteration of taste and smell as early symptoms and sequelae, but the detailed mechanism remains unclear. This study investigated whether coronavirus disease 2019-induced taste disorders are caused by direct effects on taste bud cells. SARS-CoV-2 recombinant spike and nucleocapsid proteins were applied to circumvallate papillae of male Sprague-Dawley rats. Immunohistochemistry and image analysis were used to compare the number of taste buds, and taste bud cells and area, together with confirmation of angiotensin-converting enzyme 2 (ACE2) expression. Immunohistochemical analysis revealed ACE2 expression in the taste buds of rat circumvallate papillae. Decreases in the number of taste buds, taste bud cells, and their area were observed at 12 days after application of SARS-CoV-2 recombinant spike and nucleocapsid proteins. These data suggest that SARS-CoV-2 proteins induce degeneration of taste buds.

DOI： 10.1016/j.jds.2022.03.009

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Authorship：Lead author,　Corresponding author  

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.jds.2021.10.015

PubMed

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Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：日本歯科薬物療法学会  

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Publishing type：Research paper (scientific journal)  

DOI： 10.1002/jdd.12481

Scopus

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

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Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/ca.23724

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Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

Lithium carbonate is a medication used for the management of various mental disorders. The present report describes a case of prolongation of rocuronium bromide in a patient concurrently taking lithium carbonate. A 64-year-old woman was scheduled to undergo cystectomy under general anesthesia. The patient took lithium carbonate (600 mg/d) for treatment of bipolar affective disorder. General anesthesia was induced with propofol, fentanyl, remifentanil, and sevoflurane. After loss of consciousness, rocuronium bromide (50 mg) was administered, and the trachea was intubated. Approximately 1 hour after the administration of rocuronium, the degree of residual muscle relaxant was evaluated using a nerve stimulation device. No muscle contraction occurred with train-of-four (TOF) stimulation. Following administration of sugammadex (200 mg) the TOF ratio increased to 95%. The ionic size of lithium is similar to that of sodium; therefore, lithium is transported into the cell with sodium. The resting membrane potential decreases, leading to a reduction in the height of the action potential. Thus, the effect of the remaining lithium may have been superimposed on the rocuronium neuromuscular blockade. Evaluation with a nerve stimulation device in patients taking lithium is crucial before extubation because of the risk of rocuronium potentiation.

DOI： 10.2344/anpr-66-04-04

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jds.2019.11.007

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Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Blackwell Publishing Ltd  

DOI： 10.1111/eje.12301

Scopus

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Language：English  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s10616-018-0193-9

Web of Science

Scopus

PubMed

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Authorship：Lead author,　Corresponding author   Language：English  

DOI： 10.1111/odi.12832

PubMed

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Authorship：Lead author,　Corresponding author   Language：English  

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Authorship：Lead author,　Corresponding author   Language：English  

DOI： 10.1016/j.jds.2016.02.005

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Scopus

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Language：English  

DOI： 10.3892/mco.2017.1242

PubMed

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Authorship：Corresponding author   Language：English  

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Authorship：Lead author,　Corresponding author   Language：English  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.odw.2016.10.006

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Language：English   Publisher：Osaka Odontological Society  

Lidocaine hydrochloride and alkalinized lidocaine hydrochloride solutions were filled in en­ dotracheal tube cuffs to determine the rate of diffusion of lidocaine across the cuffs, and assess the usefulness of these cuffs as a drug delivery system. Mallinckrodt^TMOral RAE^®tracheal tubes were filled with three different lidocaine solutions, i.e., mixtures of 4% lido­ caine hydrochloride solution and distilled water, 4% lidocaine hydrochloride solution an 8.4% sodium bicarbonate solution (LSB­Gr), and 4% lidocaine hydrochloride solution and dipotassium phosphate solution (LDP­Gr). Cuffs filled with the relevant lidocaine solution were placed in beakers filled with distilled water. A 100 μL sample of the water in the vessel was taken from each beaker every 30 minutes for 360 minutes to determine the concentra­ tion of lidocaine diffused across the cuff using fluorescence polarization immunoassay.The cuff surface was observed after 60, 180, and 360 minutes of exposure for changes in the structure of the material. Lidocaine in LSB­Gr and LDP­Gr diffused across the cuffs at 30 minutes of exposure and thereafter. The lidocaine concentration in water in the vessel was 133.8 μg/mL for LSB­Gr, and 119.0 μg/mL for LDP­Gr. Although the cuffs did not rup­ ture during exposure, the cuff material deteriorated over time. The results indicate that alka­ linization of intracuff lidocaine increases the rate of diffusion of lidocaine across the en­ dotracheal tube cuff and affects the cuff material, which increases the risk of complications due to cuff rupture. (J Osaka Dent Univ 2016 ;50 : 1−6)

DOI： 10.18905/jodu.50.1_1

CiNii Article

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Authorship：Lead author,　Corresponding author   Language：English  

DOI： 10.1016/j.jclinane.2015.10.004

Web of Science

PubMed

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Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1089/ten.tea.2014.0282

Web of Science

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Authorship：Lead author,　Corresponding author   Language：English  

DOI： 10.1002/ccr3.197

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PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s10616-013-9659-y

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Language：English   Publisher：Osaka Odontological Society  

We evaluated the chondrocyte differentiation potential of dedifferentiated fat cells (DFATs) and adipose stem cells (ASCs) from the human buccal fat pad (BFP). We isolated the cells from two patients who underwent oral and maxillofacial surgery. Chondrocyte differentiation was evaluated based on gene and protein expression analysis in addition to histological analysis of DFATs and ASCs seeded in an atelocollagen sponge and cultured for up to 21 days. The gene expression levels of chondrocyte differentiation markers such as aggrecan, collagen type 2, and SOX9 were higher in DFATs than in ASCs cultured for 14 and 21 days, whereas protein expression levels were higher in DFATs at all time points tested. Additionally, the levels of the embryonic stem cell markers Nanog, SOX2, and OCT4 were higher in DFATs than in ASCs at 72 h. The extracellular matrix of both the cultured ASCs and DFATs was Alcian blue-positive, indicating production of sulfated glycosaminoglycans, and was aggrecan-positive.<br> The chondrocyte differentiation ability of human DFATs was higher than that of ASCs. Isolation of DFATs from the BFP offers an aesthetic advantage, as the BFP can be obtained from the oral cavity without surface scarring. Therefore, we propose that BFP-derived DFATs are an ideal cell source for cartilage tissue engineering. This study provides evidence that DFATs from the BFP are an ideal cell source for cartilage tissue engineering.

DOI： 10.18905/jodu.49.2_185

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00784-013-1166-1

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Association of Regenerative Dentistry  

Strontium (Sr) ions are widely applied in bone regeneration therapy. However, it remains unclear whether Sr has the capacity for application in cartilage regeneration therapy using adipose-derived stem cells (ADSCs). Here, we demonstrate that the Sr ions contained in chondrogenic medium (CM) potently enhanced the chondrogenic differentiation of human ADSCs <i>in vitro</i>. Human ADSCs were isolated from the buccal fat pad of a middle-aged woman during oral surgery. ADSCs were then exposed to CM with or without Sr (0.15–15.00 mM) for up to 14 days. CM containing 1.50 mM Sr significantly increased the secretion of glycosaminoglycans (GAGs) and the mRNA expression of SRY(sex determining region Y)-box 9 and collagen type 2 alpha 1 compared with CM alone and basal medium. There were no obvious increases in adipogenic, osteoblastic, or hypertrophic chondrogenic differentiation markers. The results indicated that Sr was prospective agent to induce the chondrogenic differentiation of ADSCs.

DOI： 10.11223/jarde.12.27

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Language：English  

DOI： 10.1016/j.jds.2012.12.003

Web of Science

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s10616-012-9456-z

Web of Science

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Authorship：Lead author,　Corresponding author   Language：English   Publisher：Osaka Odontological Society  

DOI： 10.11223/jarde.8.151

CiNii Article

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Language：English  

DOI： 10.2344/0003-3006-57.1.13

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00540-009-0812-x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.joms.2008.09.017

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Language：English  

DOI： 10.1016/j.resuscitation.2008.12.011

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Language：English  

DOI： 10.18905/jodu.43.1_57

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Language：English  

DOI： 10.18905/jodu.43.1_51

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Language：English  

CiNii Article

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Authorship：Lead author,　Corresponding author   Language：English   Publisher：Japanese Association of Regenerative Dentistry  

Dedifferentiated fat cells (DFATs) possess osteogenic potential making them a promising cell source for bone regeneration. PuraMatrix^<TM> (PM), a self-assembling peptide scaffold, produces a nanoscale environment for cells. We examined radiologically the osteogenic potential and application of DFATs with PM for bone regeneration in rabbit calvarial defect models. DFATs were obtained from ceiling culture, and subsequently cultured in normal media (NM) or osteogenic media (OM). Their in vitro osteogenic differentiation potential was assessed using alizarin red staining, and by measuring osteocalcin expression and calcium concentration. Eighteen 6-mm calvarial defects were randomly treated in vivo with osteo-induced DFATs+PM, DFATs+PM, and PM scaffold, or no treatment. After 8 weeks, calvaria were harvested and the degree of healing between treatment groups was radiologically compared. Osteocalcin expression in OM significantly increased at 7 and 14 days, as well as calcium concentration at 21 days. There was no difference in healing among the four groups radiologically. Rabbit DFATs efficiently differentiate into osteoblasts when cultured in OM. To demonstrate DFAT usefulness in vivo, progressively more sophisticated animal models must be developed.

DOI： 10.11223/jarde.6.127

CiNii Article

CiNii Books

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Book type：Textbook, survey, introduction

Chapter 8 全身疾患・局所的要因、Chapter 9 局所麻酔による全身的偶発症の執筆担当

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Authorship：Lead author   Publishing type：Book review, literature introduction, etc.  

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Authorship：Lead author   Publishing type：Book review, literature introduction, etc.  

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Authorship：Lead author   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Lead author   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Lead author   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Lead author   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Lead author   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Lead author   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Lead author   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Symposium, workshop panel (nominated)  

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Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Symposium, workshop panel (nominated)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Language：English   Presentation type：Symposium, workshop panel (nominated)  

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Language：English   Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Award type：Award from Japanese society, conference, symposium, etc. 

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