Organization
University Medical and Dental Hospital Obstetrics and Gynecology Assistant Professor
Title
Assistant Professor
External link
MORI Yutaro
Degree
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博士（医学） ( 2020.3 新潟大学 )
Research Interests
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ovarian cancer
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3D culture
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endometrial cancer
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single cell RNA-seq
Research Areas
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Life Science / Molecular biology / Gynecological Malignant tumor
Research History (researchmap)
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Niigata University Graduate School of Medical and Dental Sciences OBGY Assistant Professor
2023.4
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Advanced Comprehensive Research Organization, Teikyo University
2022.4 - 2023.3
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Natinal Cancer Center Japan
2020.4 - 2022.3
Research History
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Niigata University Obstetrics and Gynecology, University Medical and Dental Hospital Assistant Professor
2023.4
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Niigata University University Medical and Dental Hospital Obstetrics and Gynecology Specially Appointed Assistant Professor
2018.4 - 2019.3
Education
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Niigata University Graduate School of Medical and Dental Sciences
2015.3 - 2020.3
Professional Memberships
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日本生殖医学会
2017.4
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日本癌学会
2016.10
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日本婦人科腫瘍学会
2012.8
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日本産科婦人科学会
2012.4
Papers
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ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer. Reviewed
Mori Y, Yamawaki K, Ishiguro T, Yoshihara K, Ueda H, Sato A, Ohata H, Yoshida Y, Minamino T, Okamoto K, Enomoto T
2019
Books
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実験医学別冊 空間オミクス解析スタートアップ実践ガイド 最新機器の特徴と目的に合った選び方、データ解析と応用例を学び、シングルセル解析の一歩その先へ！「空間トランスクリプトーム Visiumによる新鮮凍結／FFPE組織検体の解析」
森裕太郎, 山本雄介, 吉田康将, 岡本康司
2022
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実験医学増刊 Vol.39 No.12： がん微小環境に１細胞レベルで挑む、「シングルセル解析が明らかにするがん幹細胞の治療抵抗性への関与」
森裕太郎, 塩川大介, 岡本康司（ Role： Contributor）
2021
Presentations
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Elucidation of chemoresistant niches of ovarian clear cell carcinoma via integration of single-cell analyses & spatial transcriptomics.
Mori Y, Yamawaki K, Tamura R, Ishiguro T, Yoshihara K, Ueda H, Kanda Y, Shiokawa D, Enomoto T and Okamoto K
2022
Awards
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第72回日本産科婦人科学会優秀論文賞
2019.5 日本産科婦人科学会
Research Projects
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Identification of cellular networks that sustain chemoresistance of ovarian clear cell cancers through single nucleus analysis of frozen surgical specimens
Grant number：20K22826
2020.9 - 2022.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Research Activity Start-up
Awarding organization：Japan Society for the Promotion of Science
Mori Yutaro
Grant amount：\2860000 （ Direct Cost: \2200000 、 Indirect Cost：\660000 ）
Recent studies suggest that intra-tumor heterogeneity of cancer is profoundly associated with chemoresistance: cancer cells can be stratified into a several distinct populations, some of which co-operate with surrounding non-cancer cells to form cellular networks that sustain chemoresistance.
In this study, we performed single-nucleus RNA-seq analyses and spatial transcriptome of frozen surgical specimens of ovarian clear cell adenocarcinoma and we did integrate analysis of both. Integrated analysis revealed that chemoresistant cancer population was mainly localized in the mixed area of cancer cells and cancer associated fibroblasts.