Updated on 2025/06/13

写真a

 
KAWABATA Kazushige
 
Organization
Director's Room Director
Title
Director
External link

Degree

  • Doctor of Science ( 1985.3   Hokkaido University )

Research Interests

  • 細胞コロニー

  • 運動

  • 断続運動

  • ミオシン

  • ダイナミクス

  • 強弾性

  • カオス

  • 双晶変形

  • 形態

  • 力学的メモリー効果

  • 境界

  • plant architecture

  • Biophysics

  • 生物物理学

  • モータータンパク

  • システム

  • 境界面

  • 単粒子追跡法

  • エイジング現象

  • 双晶

  • エンジング現象

  • 力学平衡

  • 断続性

  • アクチン繊維

  • 細胞運動

  • 有機結晶

  • 細胞骨格

  • 走査型プローブ顕微鏡

  • 細胞

Research Areas

  • Natural Science / Mathematical physics and fundamental theory of condensed matter physics

  • Natural Science / Biophysics, chemical physics and soft matter physics

  • Life Science / Cell biology

  • Life Science / Biophysics

  • Humanities & Social Sciences / Business administration

  • Natural Science / Magnetism, superconductivity and strongly correlated systems

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Research History (researchmap)

  • Niigata University   executive vice persident

    2018.2

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  • Hokkaido University

    2013.4 - 2017.3

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  • Hokkaido University   Professor

    2010.4 - 2018.1

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  • Hokkaido University   Faculty of Advanced Life Science

    2010.4 - 2013.3

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  • Hokkaido University   Faculty of Science, Department of Biological Sciences

    2006 - 2010

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  • Hokkaido University   Professor

    2002 - 2006

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  • 北海道大学大学院理学研究科物理学専攻 助教授

    1995 - 2002

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  • Hokkaido University   School of Science Physics   Associate Professor (as old post name)

    1994 - 1995

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  • 出光興産○中央研究所 研究員

    1985 - 1994

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Education

  • Hokkaido University   理学研究科   物理学専攻

    - 1985

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    Country: Japan

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  • Hokkaido University   Graduate School, Division of Natural Science

    - 1985

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  • Hokkaido University   理学研究科   物理学専攻

    - 1982

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    Country: Japan

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  • Hokkaido University   Graduate School, Division of Natural Science

    - 1982

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  • Hokkaido University   School of Science   Physics

    - 1980

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    Country: Japan

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  • Hokkaido University   Faculty of Science

    - 1980

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Professional Memberships

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Committee Memberships

  • 北海道国立大学機構   アドバイザリーボード外部委員  

    2022.4   

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    Committee type:Academic society

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  • 文部科学省科学技術学術審議会 研究費部会   臨時委員  

    2021.3 - 2023.2   

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    Committee type:Government

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  • 内閣府   PEAKSワーキンググループ構成員  

    2021.1   

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    Committee type:Government

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  • 経済産業省   産学イノベーション人材循環育成研究会  

    2020.8 - 2022.3   

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    Committee type:Government

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  • 日本学術振興会   卓越大学院プログラム委員会委員  

    2020.4   

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    Committee type:Academic society

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  • 文部科学省   公的研究費の適正な管理に関する有識者会議  

    2019.4 - 2023.3   

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    Committee type:Government

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  • 文部科学省科学技術学術審議会   総合政策特別委員会委員  

    2017.12 - 2021.3   

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    Committee type:Government

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  • 科学技術・学術政策研究所   調査検討会 委員  

    2016.4   

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    Committee type:Government

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  • 大学評価・学位授与機構   国立大学教育研究評価委員会専門委員  

    2016.1 - 2017.3   

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  • 文部科学省   中央教育審議会(初等中等教育分科会)特別チーム委員  

    2015.11 - 2017.2   

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    Committee type:Government

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  • 文部科学省   中央教育審議会(大学分科会) 臨時委員  

    2015.4   

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  • 文部科学省   科学技術・学術審議会(人材委員会) 臨時委員  

    2015   

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Papers

  • Long-term observations reveal the formation process of branching systems of the genus Sasa in Bambusoideae Reviewed

    Hiroko Niimiya, Kazushige Kawabata

    AoB PLANTS   12 ( 5 )   plaa054   2020.9

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    <title>Abstract</title>
    Clarifying the endogenous processes that construct gross aerial shapes such as branching architecture in plants is crucial to understanding how branching contributes to plant adaptation to environments. Architectural analysis is powerful in decomposing the branching process, by comparing observations of plant growth among closely related taxa. The genus Sasa (Gramineae: Bambusoideae) contains three major sections Crassinodi, Sasa, and Macrochlamys. These sections exhibit characteristic branching architectures and are distributed separately across the Japanese archipelago, in relation to macroclimatic conditions such as snow accumulation. Our study aimed to quantitatively reveal the endogenous processes underlying branching architectures in the three sections of Sasa. Long term observations were carried out branch architectural development on Hokkaido Island from 1979 to 2012, which corresponded to the flowering interval of the genus. The results revealed that the three characteristic branching systems of the genus arise mainly from four endogenous processes (distribution of lateral buds on a culm, internode length arrangement along a culm, determination of the fate of lateral buds, development of branching with culm fragility due to aging) and their interactions with environmental conditions, especially snow accumulation. These processes are coordinated with each other over the lifespan of a single shoot in developing branching architecture.

    DOI: 10.1093/aobpla/plaa054

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  • Compressive Stress Induces Dephosphorylation of the Myosin Regulatory Light Chain via RhoA Phosphorylation by the Adenylyl Cyclase/Protein Kinase A Signaling Pathway Reviewed

    Kenji Takemoto, Seiichiro Ishihara, Takeomi Mizutai, Kazushige Kawabata, Hisashi Haga

    PLOS ONE   10 ( 3 )   2015.3

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    DOI: 10.1371/journal.pone.0117937

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  • Epithelial Sheet Folding Induces Lumen Formation by Madin-Darby Canine Kidney Cells in a Collagen Gel Reviewed

    Sumire Ishida, Ryosuke Tanaka, Naoya Yamaguchi, Genki Ogata, Takeomi Mizutani, Kazushige Kawabata, Hisashi Haga

    PLOS ONE   9   e99655   2014.8

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    DOI: 10.1371/journal.pone.0099655

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  • Substrate stiffness regulates temporary NF-kappa B activation via actomyosin contractions Reviewed

    Seiichiro Ishihara, Motoaki Yasuda, Ichiro Harada, Takeomi Mizutani, Kazushige Kawabata, Hisashi Haga

    EXPERIMENTAL CELL RESEARCH   319 ( 19 )   2916 - 2927   2013.11

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    DOI: 10.1016/j.yexcr.2013.09.018

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  • Irradiation-tolerant lung cancer cells acquire invasive ability dependent on dephosphorylation of the myosin regulatory light chain Reviewed

    Seiichiro Ishihara, Motoaki Yasuda, Takeshi Nishioka, Takeomi Mizutani, Kazushige Kawabata, Hiroki Shirato, Hisashi Haga

    FEBS LETTERS   587 ( 6 )   732 - 736   2013.3

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    DOI: 10.1016/j.febslet.2013.01.055

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  • Regulation of Cellular Contractile Force in Response to Mechanical Stretch by Diphosphorylation of Myosin Regulatory Light Chain via RhoA Signaling Cascade Reviewed

    Takeomi Mizutani, Kazushige Kawabata, Yoshikazu Koyama, Masayuki Takahashi, Hisashi Haga

    CELL MOTILITY AND THE CYTOSKELETON   66 ( 7 )   389 - 397   2009.7

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    DOI: 10.1002/cm.20378

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  • Static friction of agar gels: Formation of contact junctions at frictional interface Reviewed

    T Nitta, H Kato, H Haga, K Nemoto, K Kawabata

    JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN   74 ( 11 )   2875 - 2879   2005.11

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    DOI: 10.1143/JPSJ.74.2875

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  • Collective movement of epithelial cells on a collagen gel substrate Reviewed

    H Haga, C Irahara, R Kobayashi, T Nakagaki, K Kawabata

    BIOPHYSICAL JOURNAL   88 ( 3 )   2250 - 2256   2005.3

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    DOI: 10.1529/biophysj.104.047654

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  • Cellular stiffness response to external deformation: Tensional homeostasis in a single fibroblast Reviewed

    T Mizutani, H Haga, K Kawabata

    CELL MOTILITY AND THE CYTOSKELETON   59 ( 4 )   242 - 248   2004.12

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    DOI: 10.1002/cm.20037

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  • Intermittent motion of a twin boundary in (TMTSF)(2)PF2 Reviewed

    K Kawabata, T Saga, K Matsuda, K Nemoto, T Sambongi

    EUROPHYSICS LETTERS   64 ( 1 )   118 - 123   2003.10

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    DOI: 10.1209/epl/i2003-00145-8

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  • Time dependent static friction force of agar gel-on-glass plate immersed in water Reviewed

    T Nitta, H Haga, K Kawabata

    JOURNAL DE PHYSIQUE IV   12 ( PR9 )   319 - 320   2002.11

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    DOI: 10.1051/jp4:20020426

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  • Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts Reviewed

    M Nagayama, H Haga, K Kawabata

    CELL MOTILITY AND THE CYTOSKELETON   50 ( 4 )   173 - 179   2001.12

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    DOI: 10.1002/cm.10008

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  • Differential localization of non-muscle myosin II isoforms and phosphorylated regulatory light chains in human MRC-5 fibroblasts Reviewed

    T Saitoh, S Takemura, K Ueda, H Hosoya, M Nagayama, H Haga, K Kawabata, A Yamagishi, M Takahashi

    FEBS LETTERS   509 ( 3 )   365 - 369   2001.12

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    DOI: 10.1016/S0014-5793(01)03186-6

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  • Abnomal ferromagnetic behaviour for pyrolytic carbon under low temperature growth Reviewed

    Shigeyoshi Mizogami, Makoto Mizutani, Masahiko Fukuda, Kazushige Kawabata

    Synthetic Metals   43 ( 1-2 )   3271 - 3274   1991.6

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    DOI: 10.1016/0379-6779(91)91284-H

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  • Electronic properties of (TTF)18(I3)18(CH2Cl2)2 under high pressure Reviewed

    K. Kawabata, K. tanaka, M. Mizutani

    Synthetic Metals   42 ( 1-2 )   1917 - 1920   1991.5

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    DOI: 10.1016/0379-6779(91)91981-F

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  • Superconducting organic thin films prepared using an evaporation technique Invited Reviewed

    Kazushige Kawabata, Keiji Tanaka, Makoto Mizutani

    Advanced Materials   3 ( 3 )   157 - 159   1991

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    DOI: 10.1002/adma.19910030309

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  • Conducting thin films of α-(BEDT-TTF)2I3 by evaporation method Reviewed

    K. Kawabata, K. Tanaka, M. Mizutani

    Solid State Communications   74 ( 2 )   83 - 86   1990

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    DOI: 10.1016/0038-1098(90)90610-N

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  • Electronic and magnetic properties of (TTF)18(I3)18(CH2Cl2)2 Reviewed

    K. Kawabata, K. Tanaka, R. Hasegawa, M. Mizutani

    Solid State Communications   71 ( 5 )   361 - 364   1989

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    DOI: 10.1016/0038-1098(89)90771-0

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  • Impurity Elfects on Superconductivity and Charge Density Waves in NbSe3 Reviewed

    Kazushige Kawabata

    Journal of the Physical Society of Japan   54 ( 2 )   762 - 770   1985

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    DOI: 10.1143/JPSJ.54.762

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  • Evidence for extrinsic superconductivity in NbSe3 Reviewed

    K. Kawabata, M. Ido

    Solid State Communications   44 ( 12 )   1539 - 1542   1982

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    DOI: 10.1016/0038-1098(82)90673-1

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  • Hall Effect of NbSe3 in the Non-Ohmic Regimes Below 58 K and 142 K CDW Transitions Reviewed

    Kazushige Kawabata, Masayuki Ido, Takashi Sambongi

    Journal of the Physical Society of Japan   50 ( 6 )   1992 - 1997   1981

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    DOI: 10.1143/JPSJ.50.1992

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  • Highly Conductive 1 : 1 Radical Cation Salts of Anthra [1, 9-cd : 4, 10-c'd'] bis [1, 2] dichalcogenoles Reviewed

    TAKIMIYA K, OHNISHI A, ASO Y, OTSUBO T, OGURA F, KAWABATA K, TANAKA K, MIZUTANI M

    Bulletin of Chemical Society of Japan   67 ( 3 )   766 - 772   1974

  • Role of ATF5 in the invasive potential of diverse human cancer cell lines Reviewed

    Akihiro Nukuda, Hiroki Endoh, Motoaki Yasuda, Takeomi Mizutani, Kazushige Kawabata, Hisashi Haga

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   474 ( 3 )   509 - 514   2016.6

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    DOI: 10.1016/j.bbrc.2016.04.131

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  • Data set for comparison of cellular dynamics between human AAVS1 locus-modified and wild-type cells Reviewed

    Takeomi Mizutani, Hisashi Haga, Kazushige Kawabata

    DATA IN BRIEF   6   793 - 798   2016.3

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    DOI: 10.1016/j.dib.2015.12.053

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  • Heterogeneous filament network formation by myosin light chain isoforms effects on contractile energy output of single cardiomyocytes derived from human induced pluripotent stem cells Reviewed

    Takeomi Mizutani, Kazuya Furusawa, Hisashi Haga, Kazushige Kawabata

    REGENERATIVE THERAPY   3   90 - 96   2016.3

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    DOI: 10.1016/j.reth.2016.02.009

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  • An improved method for western blotting when extracting proteins from mammalian cells cultured on a collagen gel under serum-free conditions Reviewed

    Seiichiro Ishihara, Takeomi Mizutani, Kazushige Kawabata, Hisashi Haga

    CYTOTECHNOLOGY   68 ( 1 )   25 - 32   2016.1

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    DOI: 10.1007/s10616-014-9766-4

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  • Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression Reviewed

    A. Nukuda, C. Sasaki, S. Ishihara, T. Mizutani, K. Nakamura, T. Ayabe, K. Kawabata, H. Haga

    ONCOGENESIS   4   e165   2015.9

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    DOI: 10.1038/oncsis.2015.24

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  • Three-dimensional morphogenesis of MDCK cells induced by cellular contractile forces on a viscous substrate Reviewed

    Misako Imai, Kazuya Furusawa, Takeomi Mizutani, Kazushige Kawabata, Hisashi Haga

    SCIENTIFIC REPORTS   5 ( 14208 )   1 - 10   2015.9

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    DOI: 10.1038/srep14208

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  • Transgene integration into the human AAVS1 locus enhances myosin II-dependent contractile force by reducing expression of myosin binding subunit 85 Reviewed

    Takeomi Mizutani, Rui Li, Hisashi Haga, Kazushige Kawabata

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   465 ( 2 )   270 - 274   2015.9

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    DOI: 10.1016/j.bbrc.2015.08.018

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  • Secretion of different altered laminin isoforms results in three-dimensional morphological changes in cells cultured on Matrigel Reviewed

    Misako Imai, Takeomi Mizutani, Kazushige Kawabata, Hisashi Haga

    2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014   2015.1

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    DOI: 10.1109/MHS.2014.7006160

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  • Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin beta 1 and PI3K Reviewed

    Naoya Yamaguchi, Takeomi Mizutani, Kazushige Kawabata, Hisashi Haga

    SCIENTIFIC REPORTS   5 ( 7656 )   1 - 8   2015.1

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    DOI: 10.1038/srep07656

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  • Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices Reviewed

    Yuta Iguchi, Seiichiro Ishihara, Yoshimi Uchida, Kaori Tajima, Takeomi Mizutani, Kazushige Kawabata, Hisashi Haga

    CELL STRUCTURE AND FUNCTION   40 ( 2 )   61 - 67   2015

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  • Modulation of extracellular conditions prevents the multilayering of the simple epithelium Reviewed

    Takeomi Mizutani, Kazuki Takeda, Hisashi Haga, Mitsugu Todo, Kazushige Kawabata

    HISTOCHEMISTRY AND CELL BIOLOGY   141 ( 5 )   473 - 481   2014.5

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    DOI: 10.1007/s00418-013-1176-8

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  • Coating extracellular matrix proteins on a (3-aminopropyl)triethoxysilane-treated glass substrate for improved cell culture Reviewed

    Hiro-taka Masuda, Seiichiro Ishihara, Ichiro Harada, Takeomi Mizutani, Masayori Ishikawa, Kazushige Kawabata, Hisashi Haga

    BIOTECHNIQUES   56 ( 4 )   172 - 179   2014.4

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    DOI: 10.2144/000114156

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  • Lung Cancer Cells That Survive Ionizing Radiation Show Increased Integrin alpha 2 beta 1-and EGFR-Dependent Invasiveness Reviewed

    Xue Li, Seiichiro Ishihara, Motoaki Yasuda, Takeshi Nishioka, Takeomi Mizutani, Masayori Ishikawa, Kazushige Kawabata, Hiroki Shirato, Hisashi Haga

    PLOS ONE   8 ( 8 )   e70905   2013.8

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    DOI: 10.1371/journal.pone.0070905

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  • 1PT230 Evaluation of microtubule deformation by live cell imaging and image analysis(The 50th Annual Meeting of the Biophysical Society of Japan)

    Tanaka Ryosuke, Mizutani Takeomi, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   52   S107   2012

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    DOI: 10.2142/biophys.52.S107_5

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  • Active fluctuation in the cortical cytoskeleton observed by high-speed live-cell scanning probe microscopy Reviewed

    Kazushi Tamura, Takeomi Mizutani, Hisashi Haga, Kazushige Kawabata

    ACTA BIOMATERIALIA   7 ( 10 )   3766 - 3772   2011.10

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    DOI: 10.1016/j.actbio.2011.06.013

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  • Precise Synthesis and Physicochemical Properties of High-Density Polymer Brushes designed with Poly(N-isopropylacrylamide) Reviewed

    Hiromasa Suzuki, Huda Muhammad Nurul, Takahiro Seki, Taisuke Kawamoto, Hisashi Haga, Kazushige Kawabata, Yukikazu Takeoka

    MACROMOLECULES   43 ( 23 )   9945 - 9956   2010.12

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    DOI: 10.1021/ma101439f

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  • Nano-mechanical properties of living cells expressing constitutively active RhoA effectors Reviewed

    Kazushi Tamura, Takeomi Mizutani, Hisashi Haga, Kazushige Kawabata

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   403 ( 3-4 )   363 - 367   2010.12

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    DOI: 10.1016/j.bbrc.2010.11.036

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  • Intermediate structure between chromatin fibers and chromosome revealed by mechanical stretching and SPM measurement Reviewed International journal

    Kensuke Ikeda, Takeomi Mizutani, Osamu Hoshi, Tatsuo Ushiki, Hisashi Haga, Kazushige Kawabata

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   400 ( 1 )   181 - 186   2010.9

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    DOI: 10.1016/j.bbrc.2010.08.041

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  • Integrin beta 1-dependent invasive migration of irradiation-tolerant human lung adenocarcinoma cells in 3D collagen matrix Reviewed

    Seiichiro Ishihara, Hisashi Haga, Motoaki Yasuda, Takeomi Mizutani, Kazushige Kawabata, Hiroki Shirato, Takeshi Nishioka

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   396 ( 3 )   651 - 655   2010.6

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    DOI: 10.1016/j.bbrc.2010.04.150

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  • Dynamics of leading lamellae of living fibroblasts visualized by high-speed scanning probe microscopy Reviewed

    Kazushi Tamura, Takeomi Mizutani, Hisashi Haga, Kazushige Kawabata

    HISTOCHEMISTRY AND CELL BIOLOGY   133 ( 1 )   59 - 67   2010.1

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    DOI: 10.1007/s00418-009-0644-7

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  • 1P130 Force Oscillation observed on Pulling Chromosome to Stringlike Fiber(Nucleic acid:Structure & Property,The 48th Annual Meeting of the Biophysical Society of Japan)

    HORII TAKUYA, IKEDA KENSUKE, MIZUTANI TAKEOMI, HAGA HISASHI, KAWABATA KAZUSHIGE

    Seibutsu Butsuri   50 ( 2 )   S42   2010

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    Language:English   Publisher:The Biophysical Society of Japan General Incorporated Association  

    DOI: 10.2142/biophys.50.S42_3

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  • 2P218 Dynamic Behavior of Cytoskeletons Quantified by Digital Correlation Method(The 48th Annual Meeting of the Biophysical Society of Japan)

    Mizutani Takeomi, Ishida Sumire, Hasemi Takatoshi, Hirakawa Yuuki, Kataoka Saya, Tanaka Ryosuke, Nishida Kazuki, Yahara Masao, Takeda Kazuki, Yoshimura Ryo, Kato Munetada, Doi Kenichi, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   50 ( 2 )   S121   2010

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    DOI: 10.2142/biophys.50.S121_1

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  • Mechanical response of single myoblasts to various stretching patterns visualized by scanning probe microscopy Reviewed

    Waka Mitsui, Kazushi Tamura, Takeomi Mizutani, Hisashi Haga, Kazushige Kawabata

    ARCHIVES OF HISTOLOGY AND CYTOLOGY   72 ( 4-5 )   227 - 234   2009.12

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    DOI: 10.1679/aohc.72.227

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  • Wide range scanning probe microscopy for probing mechanical effects on cellular function Reviewed

    Takeomi Mizutani, Hisashi Haga, Kosaku Kato, Kazushige Kawabata

    ARCHIVES OF HISTOLOGY AND CYTOLOGY   72 ( 4-5 )   235 - 243   2009.12

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  • Intracellular Particles Involved in Stress Fiber Formation through Remodeling of Actin Filament Networks Reviewed

    Tamura Kazushi, Mizutani Takeomi, Haga Hisashi, Kawabata Kazushige

    BIOPHYSICAL JOURNAL   96 ( 3 )   123A   2009.2

  • Displacement of actin filament and actin binding proteins under local deformation processed by digital image correlation method in a myoblast Reviewed

    Takeomi Mizutani, Kenichi Doi, Yasuyuki Morita, Masakazu Uchino, Mitsugu Todo, Hisashi Haga, Kazushige Kawabata

    Journal of Biomechanical Science and Engineering   4 ( 3 )   415 - 422   2009

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    DOI: 10.1299/jbse.4.415

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  • Novel Function of Transcription Factor ATF5: Blockade of p53-dependent Apoptosis Induced by Ionizing Irradiation Reviewed

    Takeshi Nishioka, Yusuke Miyai, Hisashi Haga, Kazushige Kawabata, Hiroki Shirato, Akihiro Homma, Kenichiro Shibata, Motoaki Yasuda

    CELL STRUCTURE AND FUNCTION   34 ( 1 )   17 - 22   2009

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    DOI: 10.1247/csf.08041

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  • 3P-155 Cellular responses to cyclic stretch depending on velocity of the stretch(Cell bioiogy,The 47th Annual Meeting of the Biophysical Society of Japan)

    Mizutani Takeomi, Onodera Shin, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   49   S177   2009

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    DOI: 10.2142/biophys.49.S177_3

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  • 3P-159 Heterogeneous deformation of cytoskeletal network under external stretch processed by digital image correlation method(Cell bioiogy,The 47th Annual Meeting of the Biophysical Society of Japan)

    Doi Kenichi, Mizutani Takeomi, Morita Yasuyuki, Uchino Masakazu, Todo Mitsugu, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   49   S178   2009

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    DOI: 10.2142/biophys.49.S178_1

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  • 3P-158 Dynamics of Microgranular Mechanical Architecture Regulated by Actin Cytoskeleton in Leading Lamella : A Study Using High-Speed Live-Cell SPM(Cell bioiogy,The 47th Annual Meeting of the Biophysical Society of Japan)

    Tamura Kazushi, Mizutani Takeomi, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   49   S177 - S178   2009

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    DOI: 10.2142/biophys.49.S177_6

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  • 3P-160 Effect on cellular stiffness response to external stretch by memorizing more than 2 cycles of stretch in a myoblast(Cell bioiogy,The 47th Annual Meeting of the Biophysical Society of Japan)

    Takemoto Kenji, Mitsui Waka, Tamura Kazushi, Mizutani Takeomi, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   49   S178   2009

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    DOI: 10.2142/biophys.49.S178_2

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  • Mechanical response to isotropic shrinkage of fibroblasts measured by scanning probe microscopy Reviewed

    Taisuke Kawamoto, Hisashi Haga, Kazushi Tamura, Takeomi Mizutani, Kazushige Kawabata

    JAPANESE JOURNAL OF APPLIED PHYSICS   47 ( 7 )   6173 - 6176   2008.7

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    DOI: 10.1143/JJAP.47.6173

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  • 2P-250 Visualization of three-dimensional synaptic morphology of living hippocampal neurons by Scanning Probe Microscope(The 46th Annual Meeting of the Biophysical Society of Japan)

    JIANG Jun, MIZUTANI Takeomi, HAGA Hisashi, KUDOH Suguru, TAGUCHI Takahisa, KAWABATA Kazushige

    Seibutsu Butsuri   48   S113   2008

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    DOI: 10.2142/biophys.48.S113_6

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  • 3P-167 F-actin aggregates appearing during stress fiber formation : their possible role in reorganization of F-actin networks into stress fibers(The 46th Annual Meeting of the Biophysical Society of Japan)

    Tamura Kazushi, Mizutani Takeomi, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   48   S153   2008

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    DOI: 10.2142/biophys.48.S153_2

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  • Visualization of stretch-induced intracellular tensional response of single fibroblasts by mechanical scanning probe microscopy Reviewed

    Kazushi Tamura, Takeomi Mizutani, Hisashi Haga, Kazushige Kawabata

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS   46 ( 8B )   5631 - 5635   2007.8

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    DOI: 10.1143/JJAP.46.5631

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  • Development of a device to stretch tissue-like materials and to measure their mechanical properties by scanning probe microscopy Reviewed

    Takeomi Mizutani, Hisashi Haga, Kazushige Kawabata

    ACTA BIOMATERIALIA   3 ( 4 )   485 - 493   2007.7

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    DOI: 10.1016/j.actbio.2006.11.007

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  • Imaging mechanical properties of living cells by scanning probe microscopy Reviewed

    Hisashi Haga, Masafumi Nagayama, Kazushige Kawabata

    CURRENT NANOSCIENCE   3 ( 1 )   97 - 103   2007.2

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    DOI: 10.2174/157341307779940580

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  • Physics of sliding friction of gels Reviewed

    Takahiro Nitta, Kazushige Kawabata

    JOURNAL OF JAPANESE SOCIETY OF TRIBOLOGISTS   52 ( 8 )   586 - 591   2007

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  • Mechanical analysis of cellular functions using nano-technology

    Kawabata Kazushige

    Denshi kenbikyo   42 ( 2 )   136 - 138   2007

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    DOI: 10.11410/kenbikyo2004.42.136

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  • 3P192 Cell morphology and cell-matrix adhesion inducing collective movement of epithelial cells on a collagen gel substrate(Cell biological problems-adhesion, motility, cytoskeleton, signaling, and membrane,Poster Presentations)

    Ogura Hayato, Hayashi Kanako, Mizutani Takeomi, Kawabata Kazushige, Haga Hisashi

    Seibutsu Butsuri   47   S251   2007

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    DOI: 10.2142/biophys.47.S251_1

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  • S12A5 Dynamical effect on Cooperative Phenomena of Cell Systems(Unifying Comprehension from Genome to Cells through Reconsideration of Protein)

    Kawabata Kazushige

    Seibutsu Butsuri   47   S18   2007

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    DOI: 10.2142/biophys.47.S18_2

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  • 1P130 Novel intermediate structure between chromatin fiber and chromosome revealed by mechanical stretch and SPM measurement(Protein engineering, evolutionary engineering, nucleic acid-binding proteins, and nucleic acid,Oral Presentations)

    Ikeda Kensuke, Hoshi Osamu, Ushiki Tatsuo, Mizutani Takeomi, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   47   S56   2007

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    DOI: 10.2142/biophys.47.S56_1

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  • 3P199 Intracellular particles moving along actin stress fibers visualized by time-lapse scanning probe microscopy(Cell biological problems-adhesion, motility, cytoskeleton, signaling, and membrane,Poster Presentations)

    Tamura Kazushi, Mizutani Takeomi, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   47   S252   2007

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    DOI: 10.2142/biophys.47.S252_4

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  • Diphosphorylation of the myosin regulatory light chain enhances the tension acting on stress fibers in fibroblasts Reviewed

    Takeomi Mizutani, Hisashi Haga, Yoshikazu Koyama, Masayuki Takahashi, Kazushige Kawabata

    JOURNAL OF CELLULAR PHYSIOLOGY   209 ( 3 )   726 - 731   2006.12

  • Observation of stiff domain structure on collagen gels by wide-range scanning probe microscopy Reviewed

    T Mizutani, H Haga, K Kato, K Matsuda, K Kawabata

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS   45 ( 3B )   2353 - 2356   2006.3

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    DOI: 10.1143/JJAP.45.2353

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  • The role of actin-binding protein filamin A in cellular stiffness and morphology studied by wide-range scanning probe microscopy Reviewed

    K Kato, Y Ohmori, T Mizutani, H Haga, K Ohashi, T Ito, K Kawabata

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS   45 ( 3B )   2328 - 2332   2006.3

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    DOI: 10.1143/JJAP.45.2328

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  • 2P529 Tensional Responses of Single Living Cells to External Stretch Visualized by SPM(52. Bio-imaging,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

    Tamura Kazushi, Mizutani Takeomi, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   46 ( 2 )   S428   2006

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    DOI: 10.2142/biophys.46.S428_1

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  • 2P176 New filamentous ordered structure appeared by stretching of unfixed human chromosome(36. DNA to chromatin,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

    Ikeda Kensuke, Hoshi Osamu, Ushiki Tatsuo, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   46 ( 2 )   S339   2006

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    DOI: 10.2142/biophys.46.S339_4

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  • Spatiotemporal variation in cellular stiffness corresponding to development of morphological polarity Reviewed

    S Toko, T Mizutani, H Haga, K Kawabata

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS   44 ( 7B )   5451 - 5454   2005.7

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    DOI: 10.1143/JJAP.44.5451

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  • Visualization of elasticity distribution of single human chromosomes by scanning probe microscopy Reviewed

    K Nomura, O Hoshi, D Fukushi, T Ushiki, H Haga, K Kawabata

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS   44 ( 7B )   5421 - 5424   2005.7

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    DOI: 10.1143/JJAP.44.5421

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  • 1P338 Mechanical responses of single living cell to elongation and contraction : Development of a measuring system using SPM

    Tamura K., Mizutani T., Haga H., Kawabata K.

    Seibutsu Butsuri   45   S116   2005

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    DOI: 10.2142/biophys.45.S116_2

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  • 2P129 Step-like elongation of a single chromosome on mechanical stretching

    Ikeda K., Hoshi O., Ushiki T., Haga H., Kawabata K.

    Seibutsu Butsuri   45   S152   2005

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    DOI: 10.2142/biophys.45.S152_1

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  • 2SD05 Tensional Homeostasis: Stabilization of Intracellular Tension Responding to External Stress

    Mizutani T., Haga H., Takahashi M., Koyama Y., Kawabata K.

    Seibutsu Butsuri   45   S22   2005

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    DOI: 10.2142/biophys.45.S22_3

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  • Contribution of cellular contractility to spatial and temporal variations in cellular stiffness Reviewed

    M Nagayama, H Haga, M Takahashi, T Saitoh, K Kawabata

    EXPERIMENTAL CELL RESEARCH   300 ( 2 )   396 - 405   2004.11

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    DOI: 10.1016/j.yexcr.2004.07.034

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  • Wide-range scanning probe microscopy for visualizing biomaterials in the submillimeter range Reviewed

    T Mizutani, H Haga, K Nemoto, K Kawabata

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS   43 ( 7B )   4525 - 4528   2004.7

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    DOI: 10.1143/JJAP.43.4525

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  • 2P203 Tensional Home-ostasis of a Single Cell Regulated by Phosphorylation of the Myosin Regulatory Light Chain

    Mizutani T., Haga H., Takahashi M., Kawabata K.

    Seibutsu Butsuri   44   S160   2004

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    DOI: 10.2142/biophys.44.S160_3

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  • Micro-viscoelasticity evaluation of living cell

    NAGAYAMA Masafumi, HAGA Hisashi, TANAKA Yoshio, HIRAI Yoshihiko, KAWABATA Kazushige

    kenbikyo   38 ( 2 )   90 - 93   2003.7

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    DOI: 10.11410/kenbikyo1950.38.90

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  • Electronic properties of (DMTSA)BF4 at ambient pressure Reviewed

    M Nagasawa, K Kawabata, T Sambongi, P Monceau, T Otsubo

    J. de Phys. IV France   12 ( Pr9 )   317 - 318   2003.4

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    DOI: 10.1016/S0379-6779(02)00756-7

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  • Visualization of dynamic organization of cytoskeleton gels in living cells by hybrid-SPM

    K Kawabata, Y Sado, M Nagayama, T Nitta, K Nemoto, Y Koyama, H Haga

    CHINESE JOURNAL OF POLYMER SCIENCE   21 ( 2 )   169 - 174   2003.3

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  • Microdomain structure of agar gels observed by mechanical-scanning probe microscopy Reviewed

    T Nitta, Y Endo, H Haga, K Kawabata

    JOURNAL OF ELECTRON MICROSCOPY   52 ( 3 )   277 - 281   2003

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    DOI: 10.1093/jmicro/52.3.277

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  • Cooperative movement of epithelial cells induced by orientation of collagen gel fibers

    Irahara C., Haga H., Kawabata K.

    Seibutsu Butsuri   43   S109   2003

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    DOI: 10.2142/biophys.43.S109_1

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  • Cellular migration coordinated by cortical tension

    Nagayama M., Haga H., Takahashi M., Kawabata K.

    Seibutsu Butsuri   43   S108   2003

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    DOI: 10.2142/biophys.43.S108_3

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  • Recovery of Tension from Streching or Shortening Stress in Fibroblasts

    Mizutani T., Haga H., Kawabata K.

    Seibutsu Butsuri   43   S162   2003

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    DOI: 10.2142/biophys.43.S162_1

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  • Improvement of force modulation mode with scanning probe microscopy for imaging viscoelasticity of living cells Reviewed

    M Nagayama, H Haga, Y Tanaka, Y Hirai, M Kabuto, K Kawabata

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS   41 ( 7B )   4952 - 4955   2002.7

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    DOI: 10.1143/JJAP.41.4952

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  • 3N0915 Cooperative Movement and Polarity Formation of Epithelial Cells on Soft Collagen Gel

    Haga H., Hirakawa N., Irahara T., Hayashi K., Takahashi M., Kawabata K.

    Seibutsu Butsuri   42 ( 2 )   S194   2002

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    DOI: 10.2142/biophys.42.S194_2

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  • 3G0930 Mechanical-SPM measurement for fibroblasts on restricted contact area

    Miyashita H., Haga H., Kawabata K.

    Seibutsu Butsuri   42 ( 2 )   S163   2002

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    DOI: 10.2142/biophys.42.S163_1

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  • 3G0900 Mechanical Response of Fibroblast to External Stress Using Elastic Substratums

    Mizutani T., Haga H., Kawabata K.

    Seibutsu Butsuri   42 ( 2 )   S162   2002

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    DOI: 10.2142/biophys.42.S162_3

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  • Non-linear conduction in insulating phase of (DMTSA)BF4 under high pressure Reviewed

    M Nagasawa, K Kawabata, T Sambongi, T Otsubo, N Mori

    SYNTHETIC METALS   120 ( 1-3 )   1059 - 1060   2001.3

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    DOI: 10.1016/S0379-6779(00)01218-2

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  • Mechanical effects on collective phenomena of biological systems: cell locomotion Reviewed

    Kazushige Kawabata, Masafumi Nagayama, Hisashi Haga, Takashi Sambongi

    CURRENT APPLIED PHYSICS   1 ( 1 )   66 - 71   2001.1

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    DOI: 10.1016/S1567-1739(00)00013-4

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  • Evaluation of Viscoelasticity of Biological Cells in Liquid by Scanning Probe Microscopy Reviewed

    Yoshio Tanaka, Yoshihiko Hirai, Masaaki Kabuto, Kazushige Kawabata, Hisashi Haga, Masahumi Nagayama

    Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C   67 ( 663 )   3498 - 3504   2001

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    DOI: 10.1299/kikaic.67.3498

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  • Real-time observation of twin boundary motion in organic crystal (TMTSF)(2)X Reviewed

    K Kawabata, Y Hosokawa, T Kawauchi, T Sambongi

    FERROELECTRICS   251 ( 1-4 )   199 - 205   2001

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    DOI: 10.1080/00150190108008518

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  • Dynamic responses to external stress of living cells using SPM

    Sado Y., Haga H., Kawabata K.

    Seibutsu Butsuri   41   S93   2001

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    DOI: 10.2142/biophys.41.S93_2

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  • Dynamical coordinative mechanism in cell movement

    Nagayama M., Haga H., Kawabata K.

    Seibutsu Butsuri   41   S207   2001

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    DOI: 10.2142/biophys.41.S207_2

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  • Viscoelastic imaging of mechanical structure related to cell locomotion in AFM

    HAGA Hisashi, KAWABATA Kazushige

    kenbikyo   35 ( 3 )   276 - 278   2000.11

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    DOI: 10.11410/kenbikyo1950.35.276

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  • Neuronal components of the superior and inferior tentacles in the terrestrial slug, Limax marginatus Reviewed

    Ito, I, H Nakamura, T Kimura, H Suzuki, T Sekiguchi, K Kawabata, E Ito

    NEUROSCIENCE RESEARCH   37 ( 3 )   191 - 200   2000.7

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    DOI: 10.1016/S0168-0102(00)00118-8

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  • Mechanical properties of membrane surface of cultured astrocyte revealed by atomic force microscopy Reviewed

    H Shiga, Y Yamane, E Ito, K Abe, K Kawabata, H Haga

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS   39 ( 6B )   3711 - 3716   2000.6

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    DOI: 10.1143/JJAP.39.3711

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  • Comparing microscopic with macroscopic elastic properties of polymer gel Reviewed

    T Nitta, H Haga, K Kawabata, K Abe, T Sambongi

    ULTRAMICROSCOPY   82 ( 1-4 )   223 - 226   2000.2

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    DOI: 10.1016/S0304-3991(99)00170-9

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  • Elasticity mapping of living fibroblasts by AFM and immunofluorescence observation of the cytoskeleton Reviewed

    H Haga, S Sasaki, K Kawabata, E Ito, T Ushiki, T Sambongi

    ULTRAMICROSCOPY   82 ( 1-4 )   253 - 258   2000.2

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    DOI: 10.1016/S0304-3991(99)00157-6

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  • Big softer hole on living cells: Elasticity imaging with AFM

    K Kawabata, H Haga, T Nitta, Y Endo, M Nagayama, E Ito, T Sambongi

    SCANNING AND FORCE MICROSCOPIES FOR BIOMEDICAL APPLICATIONS II   3922   91 - 98   2000

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  • Real-time observation of twin boundary motion in crystals: an ideal dry friction system Reviewed

    K Kawabata, Y Hosokawa, T Saga, T Sambongi

    TRIBOLOGY LETTERS   9 ( 1-2 )   41 - 44   2000

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    DOI: 10.1023/A:1018848225662

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  • Three-dimensional characterization of interior structures of exocytotic apertures of nerve cells using atomic force microscopy Reviewed

    T Tojima, Y Yamane, H Takagi, T Takeshita, T Sugiyama, H Haga, K Kawabata, T Ushiki, K Abe, T Yoshioka, E Ito

    NEUROSCIENCE   101 ( 2 )   471 - 481   2000

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    DOI: 10.1016/S0306-4522(00)00320-1

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  • Quantitative analyses of topography and elasticity of living and fixed astrocytes Reviewed

    Y Yamane, H Shiga, H Haga, K Kawabata, K Abe, E Ito

    JOURNAL OF ELECTRON MICROSCOPY   49 ( 3 )   463 - 471   2000

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  • Time-lapse viscoelastic imaging of living fibroblasts using force modulation mode in AFM Reviewed

    H Haga, M Nagayama, K Kawabata, E Ito, T Ushiki, T Sambongi

    JOURNAL OF ELECTRON MICROSCOPY   49 ( 3 )   473 - 481   2000

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  • Evolving elasticity distribution of living cells

    Nagayama M., Haga H., Kawabata K.

    Seibutsu Butsuri   40   S80   2000

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    DOI: 10.2142/biophys.40.S80_2

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  • Visualization of cytoskeleton network and elastisity distribution of living cells using hybrid-AFM

    Sado Y., Haga H., Matsuoka I., Kawabata K.

    Seibutsu Butsuri   40   S182   2000

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    DOI: 10.2142/biophys.40.S182_2

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  • Dynamics of astrocyte adhesion as analyzed by a combination of atomic force microscopy and immunocytochemistry: the involvement of actin filaments and connexin 43 in the early stage of adhesion Reviewed

    Y Yamane, H Shiga, H Asou, H Haga, K Kawabata, K Abe, E Ito

    ARCHIVES OF HISTOLOGY AND CYTOLOGY   62 ( 4 )   355 - 361   1999.10

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    DOI: 10.1679/aohc.62.355

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  • 原子間力顕微鏡による生きた細胞の粘弾性マッピング

    川端 和重, 芳賀 永, 三本木 孝

    日本バイオレオロジー学会誌(B&R) = Journal of Japanese Society of Biorheology   13 ( 3 )   29 - 37   1999.9

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    DOI: 10.11262/jpnbr1987.13.3_29

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  • Atomic force microscopic observation of three-dimensional morphological changes of neurons where stimulated by a neurotransmitter Reviewed

    T Hosono, M Yamanaka, T Tojima, Y Yamane, H Sadamoto, D Hatakeyama, H Haga, K Kawabata, K Abe, E Ito

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS   38 ( 6B )   3940 - 3945   1999.6

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    DOI: 10.1143/JJAP.38.3940

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  • Viscoelastic Measurements on Cells in Cultured Medium Using Atomic Force Microscopy

    KAWABATA Kazushige, HAGA Hisashi

    Seibutsu Butsuri   39 ( 3 )   179 - 181   1999.5

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    DOI: 10.2142/biophys.39.179

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  • Dynamics of isolated twin boundary in (TMTSF)(2)PF6 - Control of its mobility Reviewed

    M Mukoujima, K Kawabata, T Sambongi

    EUROPEAN PHYSICAL JOURNAL B   7 ( 3 )   365 - 369   1999.2

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    DOI: 10.1007/s100510050623

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  • Time dependent viscoelastic image of living nerve cells using AFM Reviewed

    K Kawabata, H Ishizuka, T Nitta, H Haga, E Ito, K Abe, T Ushiki, T Sambongi

    BIOLOGICAL PHYSICS   487   235 - 239   1999

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  • Reexamination of Fine Surface Topography of Nerve Cells Revealed by Atomic Force Microscopy Reviewed

    TOJIMA Takuro, HATAKEYAMA Dai, KAWABATA Kazushige, ABE Kazuhiro, ITO Etsuro

    Bioimages   7 ( 2 )   89 - 94   1999

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  • Spatial and temporal viscoelastic imaging of living fibroblasts by atomic force microscopy Reviewed

    H Haga, S Sasaki, K Kawabata, E Ito, K Abe, T Sambongi

    BIOLOGICAL PHYSICS   487   229 - 234   1999

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  • Elasticity Mapping of Living Cells by AFM and Immunofluorescence Observation of Cytoskeleton.

    Haga H., Sasaki S., Kawabata K., Ito E., Ushiki T., Sambongi T.

    Seibutsu Butsuri   39   S37   1999

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    DOI: 10.2142/biophys.39.S37_1

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  • Elastic Measurement with AFM : its quantitativeness.

    NITTA Takahiro, HAGA Hisashi, KAWABATA Kazusige, ABE Kazuhiro, SAMBONGI Takashi

    Seibutsu Butsuri   39   S36   1999

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    DOI: 10.2142/biophys.39.S36_4

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  • Imaging Viscoelasticity of Living Cells using Force Modulation Mode in AFM

    Nagayama M., Haga H., Kawabata K., Ito E., Sambongi T.

    Seibutsu Butsuri   39   S37   1999

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    DOI: 10.2142/biophys.39.S37_2

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  • Atomic force microscopic and immunocytochemical study of glial cell to cell adhesion.

    Yamane Y., Shiga H., Asou H., Haga H., Kawabata K., Abe K., Ito E.

    Seibutsu Butsuri   39   S57   1999

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    DOI: 10.2142/biophys.39.S57_3

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  • Comparative atomic force and scanning electron microscopy for fine structural images of nerve cells Reviewed

    T Tojima, D Hatakeyama, Y Yamane, K Kawabata, T Ushiki, S Ogura, K Abe, E Ito

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS   37 ( 6B )   3855 - 3859   1998.6

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    DOI: 10.1143/JJAP.37.3855

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  • Fine surface images that reflect cytoskeletal structures in cultured glial cells by atomic force microscopy Reviewed

    Y Yamane, D Hatakeyama, T Tojima, K Kawabata, T Ushiki, S Ogura, K Abe, E Ito

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS   37 ( 6B )   3849 - 3854   1998.6

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    DOI: 10.1143/JJAP.37.3849

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  • Imaging elastic properties of soft materials immersed in water using force modulation mode in atomic force microscopy Reviewed

    H Haga, S Sasaki, M Morimoto, K Kawabata, E Ito, K Abe, T Sambongi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS   37 ( 6B )   3860 - 3863   1998.6

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    DOI: 10.1143/JJAP.37.3860

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  • Elastic properties of living fibroblasts as imaged using force modulation mode in atomic force microscopy Reviewed

    S Sasaki, M Morimoto, H Haga, K Kawabata, E Ito, T Ushiki, K Abe, T Sambongi

    ARCHIVES OF HISTOLOGY AND CYTOLOGY   61 ( 1 )   57 - 63   1998.3

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    DOI: 10.1679/aohc.61.57

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  • Stress induced motion of twin boundary in (TMTSF)(2)PF6 single crystal Reviewed

    M Mukoujima, T Sambongi, K Kawabata

    JOURNAL OF THE KOREAN PHYSICAL SOCIETY   31 ( 3 )   435 - 438   1997.9

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  • Effect of substrate temperature on film growth of the organic metal (BEDT-TTF)(2)I-3 Reviewed

    K Kawabata, K Shimotani, T Sambongi

    JOURNAL OF THE KOREAN PHYSICAL SOCIETY   31 ( 3 )   431 - 434   1997.9

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  • Apparent similarity between motion of twin boundary and spin-density wave sliding wave in Bechgaard salts Reviewed

    T Sambongi, M Nagasawa, M Mukoujima, K Kawabata

    JOURNAL OF THE KOREAN PHYSICAL SOCIETY   31 ( 1 )   83 - 85   1997.7

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  • Practical scan speed in atomic force microscopy for live neurons in a physiological solution Reviewed

    S Nagayama, T Tojima, M Morimoto, S Sasaki, K Kawabata, T Ushiki, K Abe, E Ito

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS   36 ( 6B )   3877 - 3880   1997.6

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    DOI: 10.1143/JJAP.36.3877

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  • Highly conducting 1:1 radical cation salts: (DMTSA)X with X=NO3 and BF4 Reviewed

    K Kawabata, M Yanai, T Sambongi, Y Aso, K Takimiya, T Otsubo

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS   296   197 - 204   1997

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    DOI: 10.1080/10587259708032321

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  • Complex motion of twin boundary in molecular crystal (TMTSF)2PF6 Reviewed

    Complexity and Diversity   108 - 110   1997

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  • Twin boundary in Bechgaard salt: Structure and unusual dynamics Reviewed

    M Mukoujima, K Kawabata, T Sambongi

    JOURNAL DE PHYSIQUE I   6 ( 12 )   1567 - 1574   1996.12

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    DOI: 10.1051/jp1:1996174

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  • Twist morphology of organic crystal (BPE-DMB)IBr2 Reviewed

    K Kawabata, T Kumagai, M Mizutani, T Sambongi

    JOURNAL DE PHYSIQUE I   6 ( 12 )   1575 - 1580   1996.12

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    DOI: 10.1051/jp1:1996175

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  • Electric and magnetic properties of a new conducting salt (DMTSA)(2)Cl (DMTSA=2,3-dimethyl-tetraselenoanthracene) Reviewed

    M Yanai, K Kawabata, T Sambongi, Y Aso, K Takimiya, T Otsubo

    SYNTHETIC METALS   79 ( 2 )   155 - 157   1996.5

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    DOI: 10.1016/0379-6779(96)80184-6

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  • Unusual motion of twin boundary in (TMTSF)(2)PF6 single crystal under constant stress Reviewed

    M Mukoujima, K Kawabata, T Sambongi

    SOLID STATE COMMUNICATIONS   98 ( 4 )   283 - 286   1996.4

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    DOI: 10.1016/0038-1098(96)00062-2

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  • Imaging nerve-terminal structure by atomic force microscopy Reviewed

    Acta Histochemica et Cytochemica   29   553 - 554   1996

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  • AFM obsevation of three dimensional fine structural chage in living neurons Reviewed

    Bioimages   4   111 - 116   1996

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  • Conducting organic complexes using dumbbell-shaped donors (BTFE-X); X=B, DMB, DMtB, DCB Reviewed

    K. Kawabata, K. Tanaka, M. Mizutani, N. Mori

    Synthetic Metals   70 ( 1 )   1141 - 1142   1995

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    DOI: 10.1016/0379-6779(94)02791-V

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  • Highly Conductive 1:1 Radical Cation Salts of Anthra(1,9-cd:4,10-c'4')bis(1,2) dichalcogenoles. Reviewed

    Takimiya Kazuo, Ohnishi Akiko, Aso Yoshio, Otsubo Tetsuo, Ogura Fumio, Kawabata Kazushige, Tanaka Keiji, Mizutani Makoto

    Bull. Chem. Soc. Jpn.   67 ( 3 )   766 - 772   1994

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    Various radical cation salts of 2,3-dimethyl-tetrathioanthracene (DMTTA) and -tetraselenoanthracene (DMTSA) with NO<sub>3</sub><sup>−</sup>, BF<sub>4</sub><sup>−</sup>, ClO<sub>4</sub><sup>−</sup>, PF<sub>6</sub><sup>−</sup>, AsF<sub>6</sub><sup>−</sup>, and Br<sup>−</sup> counter anions were prepared by an electrocrystallization technique. It has been found that these salts have either 1 : 1 or 2 : 1 stoichiometry depending on the volumes of the anions, but all are electrically conductive regardless of the stoichiometries. In particular, the NO<sub>3</sub> and BF<sub>4</sub> salts of DMTSA, in spite of 1 : 1 stoichiometry, recorded unusually high room temperature conductivities of 440 and 450 S cm<sup>−1</sup>, respectively, and had metallic behaviors down to around 200 K. In addition, the other salts were semiconductors with very low activation energies. X-Ray crystallographic analyses showed that the crystal structures of all the salts consist of one-dimensional stacking columns of the donor molecules, but the two metallic salts have more favorable uniform stacking columns in which there are not only effective π electronic interactions but also strong heteroatomic interactions. Furthermore, solid electronic spectra indicated that these 1 : 1 radical cation salts have the advantage of marked reduction of on-site Coulombic repulsion in the donor molecules, which serves to suppress a Mott transition.

    DOI: 10.1246/bcsj.67.766

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  • Synthesis of a novel donor, BETE-DMB, and its properties Reviewed

    K. Ikeda, K. Kawabata, K. Tanaka, M. Mizutani

    Synthetic Metals   56 ( 1 )   2007 - 2012   1993.3

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    DOI: 10.1016/0379-6779(93)90363-2

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  • Peculiar magnetic property of pyrolytic carbon prepared from adamantane Reviewed

    Kazuyoshi Tanaka, Masahiro Kobashi, Hideki Sanekata, Akira Takata, Tokio Yamabe, Shigeyoshi Mizogami, Kazushige Kawabata, Jun Yamauchi

    Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals   218 ( 1 )   223 - 228   1992.6

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    DOI: 10.1080/10587259208047044

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  • Synthesis of a novel donor, BTFE-DMB, and the electrical properties of its iodine salts Reviewed

    Makoto Mizutani, Keiji Tanaka, Kiyoshi Ikeda, Kazushige Kawabata

    Synthetic Metals   46 ( 2 )   201 - 205   1992

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    DOI: 10.1016/0379-6779(92)90343-H

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  • Thin films of (BEDT-TTF) iodide prepared by evaporation method Reviewed

    K. Kawabata, K. Tanaka, M. Mizutani

    Synthetic Metals   42 ( 1-2 )   2097 - 2100   1991.5

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    DOI: 10.1016/0379-6779(91)92025-D

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  • Raman spectra of the conductive salt (TTF)18(I3)18(CH2Cl2)2 Reviewed

    Makoto Mizutani, Keiji Tanaka, Kazushige Kawabata

    Synthetic Metals   44 ( 3 )   321 - 325   1991

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    DOI: 10.1016/0379-6779(91)91819-V

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  • Pressure-dependence of superconducting transition-temperature and of Hall constant in High-Tc Cu-oxide superconductors Reviewed

    N. Mori, C. Murayama, H. Takahashi, H. Kaneko, K. Kawabata, Y. Iye, S. Uchida, H. Takagi, Y. Tokura, Y. Kubo, H. Sasakura, K. Yamaya

    Physica C   185   40 - 44   1991

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  • Superconducting thin films of (BEDT-TTF) iodide Reviewed

    K. Kawabata, K. Tanaka, M. Mizutani

    Synthetic Metals   39 ( 2 )   191 - 194   1990

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    DOI: 10.1016/0379-6779(90)90183-L

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  • Ferromagnetism of pyrolytic carbon under low-temperature growth by the CVD method Reviewed

    K Kawabata, M Mizutani, M Fukuda, S Mizogami

    Synthetic Metals   33 ( 3 )   399 - 402   1989.11

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    DOI: 10.1016/0379-6779(89)90485-2

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  • Superconductivity of Pb/Si Multilayered Films Reviewed

    Kazushige Kawabata, Makoto Mizutani, Keiji Tanaka, Kenji Kawasaki

    Japanese Journal of Applied Physics   26 ( 3-2 )   1439 - 1440   1987

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    DOI: 10.7567/JJAPS.26S3.1439

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  • Correlation between superconductivity and Charge-Density Waves in Nb1-xTaxSe3 Reviewed

    K. Kawabata, M. Ido, T. Sambongi,

    J. de Phys.   44   1647 - 1650   1983

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  • Hall Effect and Transverse Conductivities of NbSe3: Evidence for the Sliding Motion of Charge-Density-Wave Reviewed

    Kazushige Kawabata, Masayuki Ido, Takashi Sambongi

    Journal of the Physical Society of Japan   50 ( 3 )   739 - 740   1981

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    DOI: 10.1143/JPSJ.50.739

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  • 細胞の形とうごきIV 細胞の形と細胞骨格

    サイエンス社  2011 

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  • Applied Scanning Probe Methods X

    Springer-Verlag  2008 

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  • Chromosome Nanoscience and Technology

    TAYLOR & FRANCIS GROUP  2007 

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MISC

  • Motion of twin boundary in (TMTSF)(2)X. Comparison with DW dynamics Reviewed

    T Sambongi, T Yokoyama, T Saga, K Kawabata

    JOURNAL DE PHYSIQUE IV   9 ( P10 )   297 - 298   1999.12

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  • Activating transcription factor 5 promotes cancer cell invasion through transcriptional activation of integrins Reviewed

    A. Nukuda, H. Endoh, S. Ishihara, M. Yasuda, T. Mizutani, K. Kawabata, H. Haga

    MOLECULAR BIOLOGY OF THE CELL   26   2015

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  • 2P173 The examination of whether deletion of myosin binding subunit 85 would lead to alteration of cellular mechanical features(12. Cell biology,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

    Li Rui, Mizutani Takeomi, Haga Hisashi, Kawabata Kazushige

    Seibutsu Butsuri   54 ( 1 )   S223   2014

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    DOI: 10.2142/biophys.54.S223_5

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  • Dynamics of Living Cells Measured by Scanning Probe Microscopy

    MIZUTANI TAKEOMI, KAWABATA KAZUSHIGE

    表面科学   34 ( 9 )   500-504 (J-STAGE) - 504   2013

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    Atomic force microscope (AFM) has advantages in the measurement of mechanical properties of soft materials. Here, we introduced applications of AFM to elucidate a single cell mechanics and multi-cellular dynamics. Comparison of elasticity map of fibroblasts with distribution of intracellular cytoskeletal fibers showed correspondence of high elasticity regions andactin fiber distributions. A representative morphology of cellular membrane ruffling was clearly observed and elasticity of the ruffling regions was higher than that of the outside of the ruffling regions. Elasticity map of epithelial cells showed cell-cell contact point is high elasticity. Cellular elasticity measurements by AFM will be applied to medical usages and some modifications of AFM will open a new door to study dynamics of soft materials.

    DOI: 10.1380/jsssj.34.500

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  • Rac1-, PI3K-, and integrin-beta 1-dependent leader cells that are essential for the collective migration of MDCK cells Reviewed

    N. Yamaguchi, T. Mizutani, K. Kawabata, H. Haga

    MOLECULAR BIOLOGY OF THE CELL   24   2013

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  • Involvement of cell polarity and cell migration in folding phenomena of epithelial sheets Reviewed

    S. Ishida, R. Tanaka, N. Yamaguchi, T. Mizutani, K. Kawabata, H. Haga

    MOLECULAR BIOLOGY OF THE CELL   23   2012

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  • EGFR and Integrin alpha 2 beta 1 Dependent Invasiveness of Lung Adenocarcinoma Cells that Survived 10 Gy Ionizing Radiation. Reviewed

    X. Li, S. Ishihara, M. Yasuda, T. Mizutani, K. Kawabata, T. Nishioka, H. Haga

    MOLECULAR BIOLOGY OF THE CELL   23   2012

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  • 細胞骨格・細胞運動・細胞移動 ラミニンを含む軟らかいゲル基質上でみられる上皮細胞集団の3次元形態形成(Cytoskeleton/ Cell motility/ Cell migration 3D Morphogenesis of Epithelial Cells on a Soft Substrate Containing Laminin Induced by Cellular Contractile Force)

    今井 美沙子, 水谷 武臣, 川端 和重, 芳賀 永

    日本細胞生物学会大会講演要旨集   63回   118 - 118   2011.5

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  • Substrate stiffness regulates NF-kB expression and activity in cancer cells Reviewed

    S. Ishihara, M. Yasuda, T. Mizutani, K. Kawabata, H. Haga

    MOLECULAR BIOLOGY OF THE CELL   22   2011

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  • 3D Morphogenesis of Epithelial Cells on a Laminin-rich Soft Substrate Induced by Cellular Contractile Force Reviewed

    M. Imai, T. Mizutani, K. Kawabata, H. Haga

    MOLECULAR BIOLOGY OF THE CELL   22   2011

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  • 21pEC-6 SPM observations of mechanical responses of living cells

    Kawabata Kazushige

    Meeting abstracts of the Physical Society of Japan   65 ( 1 )   305 - 305   2010.3

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  • Increased Invasiveness and Non-spheroid Morphology Change of Human Lung Adenocarcinoma Cells That Survived 10 Gy Irradiation

    T. Nishioka, S. Ishihara, Y. Miyai, T. Mizutani, K. Kawabata, H. Shirato, R. Yamazaki, M. Yasuda, H. Haga, K. Kawabata

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   75 ( 3 )   S540 - S540   2009

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  • 757 Numerical simulation of a colony of cells by using a particle method

    SUEYOSHI Makoto, HU Changhong, TODO Mitsugu, MIZUTANI Takeomi, KAWABATA Kazushige

    The Computational Mechanics Conference   2008 ( 21 )   876 - 877   2008.11

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  • 走査型プローブ顕微鏡による細胞機能の解析

    水谷武臣, 芳賀永, 加藤幸作, 川端和重

    細胞   40 ( 6 )   250 - 253   2008.6

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  • Spatial Distribution of Elasticity in Living Cell Surfaces Imaged by Scanning Probe Microscopy

    HAGA Hisashi, MIZUTANI Takeomi, KAWABATA Kazushige

    Journal of the Surface Science Society of Japan   29 ( 4 )   235 - 238   2008.4

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  • 18pWH-7 Elementary Process of Friction of Polymer Gels and Its Control

    Kawabata Kazushige

    Meeting abstracts of the Physical Society of Japan   62 ( 1 )   882 - 882   2007.2

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  • Three-dimensional tumor cell movement in collagen gel: mesenchymal-to-amoeboid transition in a sub-clone that survived 10 Gy irradiation

    T. Nishioka, H. Haga, Y. Miyai, M. Yasuda, K. Tsutsumi, R. Yamazaki, H. Shirato, K. Kawabata

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   69 ( 3 )   S148 - S148   2007

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  • 30pXG-5 Thermal effects on static frictions of agar gels

    Inazuki Y., Haga H., Nemoto K., Kawabata K.

    Meeting abstracts of the Physical Society of Japan   61 ( 1 )   338 - 338   2006.3

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  • Wave-like collective movement of epithelial cells on a collagen gel substrate Reviewed

    Yukiko Ohmori, Hisashi Haga, Kazushige Kawabata

    CELL STRUCTURE AND FUNCTION   30   60 - 60   2005.6

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  • Spatial and temporal organization in collective movement of epithelial cells on a collagen gel substrate Reviewed

    Kanako Hayashi, Hisashi Hag, Kazushige Kawabata

    CELL STRUCTURE AND FUNCTION   30   60 - 60   2005.6

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  • Homeostasis of intracellular tension to external deformation regulated by phosphorylation and dephosphorylation of myosin regulatory light chain Reviewed

    Takeomi Mizutani, Hisashi Haga, Masayuki Takahashi, Yoshikazu Koyama, Kazushige Kawabata

    CELL STRUCTURE AND FUNCTION   30   110 - 110   2005.6

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  • Contribution of actin-binding protein filamin a to the spatial and temporal variation of nonmuscle stress fibers Reviewed

    Kosaku Kato, Hisashi Haga, Kazuyo Ohashi, Tadanao Ito, Thomas P. Stossel, Kazushige Kawabata

    CELL STRUCTURE AND FUNCTION   30   56 - 56   2005.6

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  • Instrumentation of Wide-Range Scanning Probe Microscopy and the Applications to Cell Biology and Biomaterial Science

    MIZUTANI Takeomi, HAGA Hisashi, KAWABATA Kazushige

    Biophysics   45 ( 2 )   105 - 108   2005.3

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    DOI: 10.2142/biophys.45.105

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  • Collective movement of epithelial cells on collagen gel substrate

    H Haga, C Irahara, R Kobayashi, T Nakagaki, K Kawabata

    BIOPHYSICAL JOURNAL   88 ( 1 )   429A - 429A   2005.1

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  • 細胞のダイナミクスと集団運動(ソフトマターの物理学2004-変形と流動-,研究会報告)

    水谷 武臣, 芳賀 永, 川端 和重

    物性研究   83 ( 3 )   333 - 334   2004.12

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    この論文は国立情報学研究所の電子図書館事業により電子化されました。

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  • Collective and unidirectional movement of epithelial cells on a collagen gel substrate

    H Haga, K Hayashi, K Kawabata

    MOLECULAR BIOLOGY OF THE CELL   15   179A - 179A   2004.11

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  • Tensional homeostasis of a single fibroblast regulated by phosphorylation of the myosin regulatory light chain Reviewed

    M Takeomi, H Haga, M Takahashi, K Kawabata

    MOLECULAR BIOLOGY OF THE CELL   15   159A - 159A   2004.11

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  • Domain like structure of human-chromosome observed by mechanical scanning probe microscopy

    K Kawabata, K Nomura, H Haga, O Hoshi, D Fukushi, T Ushiki

    MOLECULAR BIOLOGY OF THE CELL   15   329A - 329A   2004.11

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  • 14aTC-9 Temperature effect of static friction of agar gels

    Kawabata K., Kato H., Nitta T., Nemoto K., Haga H.

    Meeting abstracts of the Physical Society of Japan   59 ( 2 )   232 - 232   2004.8

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  • Long-acting changes of cellular stiffness on responding to external stress Reviewed

    Takeomi Mizutani, Hisashi Haga, Kazushige Kawabata

    CELL STRUCTURE AND FUNCTION   29   23 - 23   2004.5

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  • Collective movement of epithelial cells accompanied by rearrangement and decomposition of collagen gel substrate Reviewed

    O. Kanako Hayashi, Hisashi Haga, Kazushige Kawabata

    CELL STRUCTURE AND FUNCTION   29   29 - 29   2004.5

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  • The role of actin-binding protein filamin a in cell movement and stress fiber formation Reviewed

    O. Yukiko Ohmori, Hisashi Haga, Tadanao Ito, Kauyo Ohashi, Thomas Stossel, Kazushige Kawabata

    CELL STRUCTURE AND FUNCTION   29   28 - 28   2004.5

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  • 28aYD-2 Mesoscale Friction of Biological Systems : Direct Observation of Frictional Interface of Polymer Gels

    Kawabata K.

    Meeting abstracts of the Physical Society of Japan   59 ( 1 )   287 - 287   2004.3

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  • 29pWA-4 Static friction of polymer gels : waiting time dependence of real contact area

    Kato H., Nitta T., Haga H., Nemoto K., Kawabata K.

    Meeting abstracts of the Physical Society of Japan   59 ( 1 )   309 - 309   2004.3

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  • 高分子ゲルの静止摩擦の待機時間効果 : 真実接触領域の直接観察(摩擦の物理,研究会報告)

    加藤 秀章, 新田 高洋, 芳賀 永, 川端 和重

    物性研究   81 ( 6 )   860 - 863   2004

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    Other Link: http://dl.ndl.go.jp/info:ndljp/pid/10940750

  • Temperature effect on motion of isolated twin boundary II

    Matsuda M., Sambongi T., Kawabata K.

    Meeting abstracts of the Physical Society of Japan   58 ( 2 )   201 - 201   2003.8

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  • Static Friction of Polymer Gel : Direct Observation of Real Contact Area

    Kato H., Nitta T., Haga H., Kawabata K.

    Meeting abstracts of the Physical Society of Japan   58 ( 2 )   201 - 201   2003.8

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  • Sliding friction of polymer gel : Transition from lubricational state to frictional state

    Kato H., Nitta T., Haga H., Kawabata K.

    Meeting abstracts of the Physical Society of Japan   58 ( 1 )   287 - 287   2003.3

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  • Motion of Isolated Twin boundary : Temperature Effect on Memory Effect

    Kawabata K., Yonemichi T., Matuda K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   58 ( 1 )   288 - 288   2003.3

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  • Time-Lapse Observation of Local Stiffness Distribution Correlating to Cell Migration Using Nano-Force SPM

    HAGA Hisashi, NAGAYAMA Masafumi, TAKAHASHI Masayuki, KAWABATA Kazushige

    2003 ( 15 )   19 - 20   2003.1

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  • Cellular migration driven by relaxation of cortical tension imaged with mechanical force microscopy

    M Nagayama, H Haga, M Takahashi, K Kawabata

    MOLECULAR BIOLOGY OF THE CELL   13   193A - 193A   2002.11

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  • Sliding friction of polymer gel : Static friction III

    Nitta Takahiro, Kawabata Kazushige, Haga Hisashi

    Meeting abstracts of the Physical Society of Japan   57 ( 2 )   211 - 211   2002.8

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  • X-ray Irradiation Effect on Motion of Isolated Twin boundary in Organic Crystals

    Yonemichi T., Kawabata K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   57 ( 2 )   210 - 210   2002.8

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  • Electronic properties of (DMTSA)BF_4 at ambient pressure

    Nagasawa M., Kawabata K., Sambongi T., Monceau P., Ohtsubo T.

    Meeting abstracts of the Physical Society of Japan   57 ( 2 )   685 - 685   2002.8

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  • Mechanical Observation of Living Cells Using Hybrid-Scanning Probe Microscopy

    KAWABATA Kazushige, SADO Yasuhiro, NAGAYAMA Masafumi, HAGA Hisashi

    Japanese journal of optics   31 ( 6 )   483 - 488   2002.6

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  • 24pXK-13 Sliding friction of polymer gel : Static friction II

    Nitta Takahiro, Haga Hisashi, Kawabata Kazushige

    Meeting abstracts of the Physical Society of Japan   57 ( 1 )   241 - 241   2002.3

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  • Stiffness change of living fibroblasts depending on cell motion

    M Nagayama, H Haga, K Kawabata

    MOLECULAR BIOLOGY OF THE CELL   12   171A - 171A   2001.11

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  • Sliding friction of polymer gel : Static friction

    Nitta Takahiro, Haga Hisashi, Kawabata Kazushige

    Meeting abstracts of the Physical Society of Japan   56 ( 2 )   183 - 183   2001.9

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  • Motion of Twin Boundary in Organic Crystals : Threshold Stress

    KAWABATA K., HOSOKAWA Y., SAMBONGI T.

    Meeting abstracts of the Physical Society of Japan   56 ( 2 )   184 - 184   2001.9

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  • Motion of domain walls in ferroelastic NdP_5O_<14>

    Kawauchi T., Kawabata K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   56 ( 2 )   184 - 184   2001.9

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  • 919 Evaluation of Viscoelasticity of Biomaterials in Liquid by Atomic Force Microscope

    TANAKA Yoshio, Hirai Yoshihiko, Kabuto Masaaki, KAWABATA Kazushige, HAGA Hisashi, NAGAYAMA Masahumi

    2001 ( 76 )   "9 - 43"-"9-44"   2001.3

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    Knowledge of viscoelasticity distribution of a living biological cell is useful for investigation of a relationship between its motility and cellular structure. This paper proposes a strict evaluation method of viscoelasticity of cells through vibration analysis of AFM cantilever in water by considering resistance force of cells against cantilever tip penetration and drag force of water due to the cantilever vibration. Cyclic penetration of the tip is presently given by the vibration of the table, while additional vertical motion is applied to the table to avoid the effect of. topography on the evaluation of the viscoelasticity. A map of viscoelasticity distribution is taken by scanning motion of the table.

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  • Dynamic analysis of moving cells using nano-mechanical SPM (日本電子顕微鏡学会第46回シンポジウム 材料のナノ・生物のナノ) -- (共通セッション2 走査プローブ顕微鏡の生物応用--"7th International Symposium on Advanced physical Fields(APF-7)"との合同セッション)

    川端 和重, Sado Y., Nagayama M.

    電子顕微鏡   36   74 - 77   2001

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  • Motion of domain walls in ferroelastic NdP_5O_<14>

    Kawauchi T., Kawabata K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   55 ( 2 )   861 - 861   2000.9

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  • Motion of Isolated Twin Boundary in Organic Complex (TMTSF)_2ClO_4 IV

    HOSOKAWA Y., KAWABATA K., SAMBONGI T.

    Meeting abstracts of the Physical Society of Japan   55 ( 2 )   861 - 861   2000.9

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  • Temporal and Spatial Viscoelastic Imaging of Cell Locomotion by AFM

    NAGAYAMA M., HAGA H., KAWABATA K., SAMBONGI T.

    35   359 - 359   2000.5

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  • Motion of Twin Boundary in Organic Complex (TMTSF)_2X : Intermission

    Saga T., Kawabata K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   55 ( 1 )   823 - 823   2000.3

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  • Local Elastic Modulus Mapping of Ager Gel with AFM

    Nitta T., Haga H., Kawabata K., Abe K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   55 ( 1 )   285 - 285   2000.3

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  • Nonlinear conduction on (DMTSA)BF_4 under pressure (II)

    Nagasawa M., Kawabata K., Sambongi T., Ohtsubo T., Mori N.

    Meeting abstracts of the Physical Society of Japan   55 ( 1 )   710 - 710   2000.3

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  • 液中環境における生きた細胞の粘弾性マッピング

    川端 和重, 芳賀 永

    Molecular electronics and bioelectronics   10 ( 4 )   215 - 220   1999.10

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  • 24pE-11 Nonlinear conduction on (DMTSA)BF_4 under pressure

    Nagasawa M., Kawabata K., Sanbongi T., Ohtsubo T.

    Meeting abstracts of the Physical Society of Japan   54 ( 2 )   734 - 734   1999.9

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  • 24pYJ-11 Motion of domain walls in ferroelastic NdP_5O_<14>

    SAMBONGI T, KAWABATA K

    Meeting abstracts of the Physical Society of Japan   54 ( 2 )   866 - 866   1999.9

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  • 24pYJ-13 Motion of Twin Boundary in Organic Complex(TMYSF)_2X : Intermission

    Saga T, Kawabata K, Sambongi T

    Meeting abstracts of the Physical Society of Japan   54 ( 2 )   866 - 866   1999.9

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  • 24pYJ-12 Motion Isolated Twin Boundary in Organic Complex(TMYSF)_2X II

    MUKOUJIMA M, KAWABATA K, SAMBONGI T

    Meeting abstracts of the Physical Society of Japan   54 ( 2 )   866 - 866   1999.9

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  • Viscoelastic imaging of living cell in culture medium using AFM

    KAWABATA K., HAGA H.

    34   35 - 35   1999.5

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  • 31p-XB-7 Temperature dependence of conductivity of 1:1 radical cation salt(DMTSA)BF_4 under high pressure

    Akita M., Kawabata K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   54 ( 1 )   274 - 274   1999.3

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  • 31a-M-12 Motion of a Twin Boundary Ferroelastic Organic Salt(TMTSF)_2X

    Yokoyama T., Kawabata K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   54 ( 1 )   134 - 134   1999.3

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  • 29a-XD-9 Motion of Twin Boundary in Organic Complex (TMTSF)_2X : Intermission

    Saga T., Kawabata K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   54 ( 1 )   658 - 658   1999.3

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  • 29a-XD-8 Motion of Twin Boundary in Organic Complex (TMTSF)_2X : Long-Time Relaxation

    MUKOUJIJA M., KAWABATA K., SAMBONGI T.

    Meeting abstracts of the Physical Society of Japan   54 ( 1 )   658 - 658   1999.3

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  • Dynamics of isolated twin boundary in organic bechgaard salts crystal and long-time relaxation of its mobility

    K Kawabata, T Yokoyama, M Mukoujima, T Saga, T Sambongi

    SLOW DYNAMICS IN COMPLEX SYSTEMS   469   675 - 676   1999

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  • AFM analysis of morphological changes in cerebellar granule cells induced by agonists for receptors.

    Hosono T., Yamanaka M., Tojima T., Sadamoto H., Kawabata K., Abe K., Ito E.

    Biophysics   38 ( 2 )   S201   1998.9

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  • Imaging the Viscoelasticity of Living Cell with AFM(III)

    Haga H., Sasaki S., Nitta T., Kawabata K., Ito E., Abe K., Sambongi T.

    Biophysics   38 ( 2 )   S144   1998.9

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  • Imaging the Viscoelasticity of Living Cell with AFM(IV)

    Kawabata K., Ishizuka H., Morimoto M., Haga H., Ito E., Abe K., Sambongi T.

    Biophysics   38 ( 2 )   S144   1998.9

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  • Atomic Force Microscopic Observation of Fine Surface Structures Which Reflect Cytoskeletons in Glial Cells

    YAMANE Y., HATAKEYAMA D., HAGA H., KAWABATA K., ABE K., ITO E.

    Meeting abstracts of the Physical Society of Japan   53 ( 2 )   857 - 857   1998.9

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  • Imaging Viscoelasticity of Living Nerve Cell with AFM(III)~Fine Globular Morphology in the Peripheral Region~

    HAGA H., MORIMOTO M., SASAKI S., KAWABATA K., ITO E., ABE K., SAMBONGI T.

    Meeting abstracts of the Physical Society of Japan   53 ( 1 )   738 - 738   1998.3

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  • Imaging Viscoclasticity of Living Fibroblast with AFM(II)~Fine Morphology of lamellipodia and its time dependence~

    SASAKI S., HAGA H., KAWABATA K., ITO E., ABE K., SAMBONGI T.

    Meeting abstracts of the Physical Society of Japan   53 ( 1 )   737 - 737   1998.3

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  • Low Temperature Electronic Heat Capacity of 1:1 Radical Cation Salt(DMTSA)BF_4

    AKITA M., KAWABATA K., SAMBONGI T.

    Meeting abstracts of the Physical Society of Japan   53 ( 1 )   231 - 231   1998.3

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  • Unusual Motion of a Twin Boundary in Organic Complex (TMTSF)_2X III

    YOKOYAMA T., KAWABATA K., SAMBONGI T.

    Meeting abstracts of the Physical Society of Japan   53 ( 1 )   112 - 112   1998.3

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  • Unusual Motion of a Twin Boundary in Organic Crystal (TMTSF)_2X II

    MUKOUJIMA M., KAWABATA K., SAMBONGI T.

    Meeting abstracts of the Physical Society of Japan   53 ( 1 )   111 - 111   1998.3

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  • Fine structure of exocytotic aperture in nerve cells revealed by AFM

    TOJIMA T., YAMANE Y., KAWABATA K., ITO E., TAKAGI H., TAKESHITA T., YOSHIOKA T., USHIKI T., ABE K.

    Biophysics   37   S116   1997.10

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  • 5p-M-12 Motion of Twin Boundary in Organic Complex(TMTSF)_2 ClO_4

    Yokoyama T., Kawabata K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   52 ( 2 )   889 - 889   1997.9

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  • 6a-S-7 Unusual Motion of Twin Boundary in Organic Crystal (TMTSF)_2X

    Mukoujima M., Sambongi T., Kawabata K.

    Meeting abstracts of the Physical Society of Japan   52 ( 2 )   102 - 102   1997.9

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  • 6a-C-2 Electrical, Magnetic and Thetmal Properties of 1:1 Radical Cation Salt(DMTSA)BF_4

    Akita M., Kawabata K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   52 ( 2 )   275 - 275   1997.9

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  • 8a-P-4 Imaging the Viscoelasticity of Living Cell with AFM

    Haga H., Morimoro M., Sasaki S., Kawabata K., Ito E., Abe K., Sambongi T.

    Meeting abstracts of the Physical Society of Japan   52 ( 2 )   853 - 853   1997.9

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  • 有機電荷移動錯体 (TMTSF)_2PF_6における双晶境界面の特異な運動

    向島 美香, 三本木 孝, 川端 和重

    電子情報通信学会技術研究報告. OME, 有機エレクトロニクス   97 ( 88 )   19 - 23   1997.6

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    (TMTSF)_2Xは、擬一次元的な電気伝導度を示す低次元電荷移動型有機錯体である。(TMTSF)_2Xの単結晶に適当な外力を加えると、結晶の一部に双晶変形が生じる。孤立したkinkの運動の観測を(TMTSF)_2PF_6単結晶を使っておこなったところ、一定の応力下でも、間欠性や速度のばらつきのような複雑な振る舞いを示した。しかし、kinkの変位の時間依存性を示す曲線は一つの曲線に規格化が可能であることを見いだし、これより結晶中のkinkの運動は欠陥の分布などの結晶内に固定された要因以外に運動を支配する要因があることがわかった。さらにこの要因は運動前の履歴に強く関係していることがわかった。

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  • 29a-WE-3 Application of a biological AFM to live neurons

    Nagayama S, Tojima T, Kawabata K, Ushiki T, Abe K, Ito E

    Meeting abstracts of the Physical Society of Japan   52 ( 1 )   766 - 766   1997.3

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  • Metallic conduction under high pressures and magnetic properties of 1:1 salt(DMTSA)BF_4

    Yanai M., Kawabata K., Sambongi T., Ohtsubo T., Takimiya K., Aso Y.

    Abstracts of the meeting of the Physical Society of Japan. Sectional meeting   1996 ( 2 )   427 - 427   1996.9

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  • Twist morphology of organic crystal(BPE-DMB)IBr_2

    Kawabata K., Yanai M., Kumagai T., Mizutani M., Sambongi T.

    Abstracts of the meeting of the Physical Society of Japan. Sectional meeting   1996 ( 2 )   424 - 424   1996.9

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  • Unusual Motion of Twin Boundary in Bechgaard Salt II

    Mukoujima M., Kawabata K., Sambongi T.

    Abstracts of the meeting of the Physical Society of Japan. Sectional meeting   1996 ( 2 )   423 - 423   1996.9

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  • Twin Boundary Motion in Bechgaard Salts

    Mukoujima M., Kawabata K., Sambongi T.

    Abstracts of the meeting of the Physical Society of Japan. Sectional meeting   1996 ( 4 )   94 - 94   1996.9

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  • 3D-structural observation of synaptic formation with AFM

    S Nagayama, M Morimoto, T Tojima, K Kawabata, Y Fujito, S Ogura, K Abe, T Ushiki, E Ito

    PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY   65   PG313 - PG313   1996

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  • 29a-K-1 Electrical and magnetic properties of highly conductive 1:1 radical cation salt(DMTSA)BF_4

    Yanai M, Kawabata K, Sambongi T, Ohtsubo T, Takimiya K, Aso Y

    Abstracts of the meeting of the Physical Society of Japan. Sectional meeting   1995 ( 2 )   387 - 387   1995.9

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  • 29a-K-7 Crystal Structure and Physical Properties of Conducting Thin Films of(BEDT-TTF)_2I_3

    Shimotani K, Kawabata K, Sambongi T

    Abstracts of the meeting of the Physical Society of Japan. Sectional meeting   1995 ( 2 )   390 - 390   1995.9

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  • Electric and structural properties of (BPE-DMB)IBr_2

    Kumagai T, Kawabata K, Mizutani M, Sambongi T

    Abstracts of the meeting of the Physical Society of Japan. Annual meeting   50 ( 2 )   414 - 414   1995.3

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  • Electric properties of conducting organic complexes (DMTSA)X;(X=BF / NO3)

    Yanai M, Kawabata K, Takimiya K, Ohtsubo T, Ogura F, Sambongi T

    Abstracts of the meeting of the Physical Society of Japan. Annual meeting   50 ( 2 )   414 - 414   1995.3

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  • 3a-S-3 Conducting thin film of charge-transfer complexes by exaporation method

    Kawabata K, Shimotani K, Mizutani M, Sambongi T

    Abstracts of the meeting of the Physical Society of Japan. Sectional meeting   1994 ( 2 )   269 - 269   1994.8

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  • 29p-ZF-10 Pressure induced resistive anomalies of (BTFV-DMB) iodide.

    KAWABATA K., IKEDA K., TANAKA K., MIZUTANI M.

    46 ( 2 )   334 - 334   1991.9

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  • 25a-Z-7 Evaporated Films of Charge-Transfer Complexes

    Kawabata K., Tanaka K., Mizutani M.

    1991 ( 2 )   334 - 334   1991.3

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  • Characterization and preparation of evaporated films of BEDT-TTF iodide (II)

    KAWABATA K., MIZUTANI M., TANAKA K.

    45 ( 2 )   328 - 328   1990.3

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  • 3a-M-6 Characterization and preparation of evaporated films of BEDT-TTF iodie

    KAWABATA K., MIZUTANI M., TANAKA K.

    1989 ( 2 )   280 - 280   1989.9

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  • 3a-M-5 Electronic properties of (TTF)_<18>(I_3)_<18>(CH_2Cl_2)_2 under pressure

    KAWABATA K., MIZUTANI M., TANAKA K.

    1989 ( 2 )   280 - 280   1989.9

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  • 29a-P-1 Physical properties of (TTF)_<18>(I_3)_<18>(CH_2Cl_2)_2

    KAWABATA K., MIZUTANI M., TANAKA K.

    44 ( 2 )   291 - 291   1989.3

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  • 4a-C-9 Nb/II-VI族半導体積層膜の超伝導特性

    水谷 眞, 川端 和重, 田中 啓治

    秋の分科会講演予稿集   1985 ( 3 )   246 - 246   1985.9

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  • 13p-PS-22 Nb_<1-x>MxSe_3(M=Ta,Ti)における超伝導とCDWIII

    川端 和重, 伊土 政幸, 三本木 孝

    秋の分科会講演予稿集   1983 ( 2 )   201 - 201   1983.9

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  • 30p-M-4 Nb_<1-x>Ta_xSe_3(0&le;x&le;0.2)における超伝導とCDW II

    川端 和重, 伊土 政幸, 三本木 孝

    年会講演予稿集   38 ( 2 )   209 - 209   1983.3

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  • 30p-B-7 Nb_<1-x>Ta_xSe_3における超伝導とCDW

    川端 和重, 伊土 政幸, 三本木 孝

    年会講演予稿集   37 ( 2 )   131 - 131   1982.9

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  • 2p-NL-14 NbSe_3の非線型伝導領域におけるHall効果 II

    川端 和重, 伊土 政幸, 三本木 孝

    秋の分科会講演予稿集   1981 ( 2 )   138 - 138   1981.9

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  • 2p-NL-13 TaS_3における非線型電気伝導

    伊土 政幸, 川端 和重, 三本木 孝

    秋の分科会講演予稿集   1981 ( 2 )   138 - 138   1981.9

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Awards

  • ナノプローブテクノロジー賞

    2007  

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  • 2005年日本物理学会誌注目論文

    2005  

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  • 2005 Papers of Editors' Choice, Journal of Physical Society of Japan

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Research Projects

  • Aimed for the elucidation of mechanism of collective multi-cellular migration during 3D morphogenesis

    Grant number:25287106

    2013.4 - 2018.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    KAWABATA Kazushige

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    Grant amount:\18850000 ( Direct Cost: \14500000 、 Indirect Cost:\4350000 )

    Construction of 3D structures by multi cellular system, such as blood vessel, clusters of air-exchanging sacks, produces specific functions. To construct 3D structures, cells should move collectively. However, the mechanism of cellular collective movement is not unclear yet. This project is aimed to elucidate mechanism of cellular collective movement by developing cell tracking system, 2D and 3D cellular traction force measurement, cell junction protein-knockout cell lines. In addition, we simulated multi cellular collective movement by making motion equation for cells. Combination of cell tracking system and established knockout cell lines showed that collective movement requires a cell-cell junction protein. The results of computer simulation indicated that important factor is not only cell-cell contact but also cellular modulate elasticity. These findings may be useful to design an intended 3D structure in the field of tissue regeneration.

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  • A method for observation of multi-cellular mechanics by fluorescent microscopy

    Grant number:23651099

    2011 - 2012

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    KAWABATA Kazushige, MIZUTANI Takeomi

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    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    We tried to establish methods to measure strain within cytoskeletons or strain between cells. These methods will help us to study mechanical interaction between cytoskeletons or multi-cellular movement.

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  • Collective migration of epithelial cells induced by softness of substrates

    Grant number:21570158

    2009 - 2011

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    HAGA Hisashi, KAWABATA Kazushige

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Cell movement plays an important role in many physiological processes, including wound healing, embryonic development, and morphogenesis. In this study, we observed that epithelial cells (Madin-Darby canine kidney cell) migrated collectively along one direction on a soft substrate. Cell-substrate adhesions, cell-cell mechanotransduction, and appearance of leader cells were studied.

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  • 細胞骨格のプレハブ再構築仮説の実証

    Grant number:21654058

    2009 - 2010

    System name:科学研究費助成事業 挑戦的萌芽研究

    Research category:挑戦的萌芽研究

    Awarding organization:日本学術振興会

    川端 和重, 水谷 武臣

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    Grant amount:\3000000 ( Direct Cost: \3000000 )

    細胞内における物質輸送は、細胞の巨視的な活動(形態形成や運動など)を考える上で重要な現象である。走査型プローブ顕微鏡(SPM)を用いて、生きた細胞を我々は、既存装置の約500倍の高速(測定時間:数sec/frame)で測定できる生体高速SPM測定法を開発した。この装置を用いて、生きた細胞の骨格形成のダイナミクスを測定し、単粒子追跡解析法によってその運動を解析した。
    その結果、細胞表面で数百nm径のアクチン繊維(F-actin)からなる硬い顆粒が多数生成し、ブラウン運動に似た拡散運動をした。モータータンパク質であるミオシンIIを阻害する薬剤(ブレビスタチン)の投与および温度のわずかな低下によって、顆粒の拡散速度が著しく低下した。よって、顆粒の運動は、アクチンネットワークがモータータンパクによってランダムに張力が働き、その結果、拡散が起こっているといえる。
    この機構が、細胞膜付近の小胞にも起こっているか否かを膜小胞について調べた。小胞に局在するRab5タンパク質を緑色蛍光タンパク質で標識しその運動を調べた結果、単純拡散様の性質は見られなかったものの、熱的な揺動力による細胞骨格線維の曲げ変形の理論と一致する性質を見出した。この性質は、細胞骨格を破壊する試薬を投与することにより大きく乱された。従って、膜小胞の動きには細胞骨格が寄与しているものの、細胞骨格線維の滑り運動ではなく曲げ変形の動力学が支配的に働いていると考えられる。
    細胞膜付近における小胞輸送には、細胞骨格の曲げ変形のダイナミクスが輸送過程を支配している。ここに活性化したミオシンIIが加わると、ミオシンIIが局所的にアクチン線維同士の架橋を破壊しながらアクチン線維を滑らせる。この滑り運動に基づいて新たに単純拡散様の輸送過程が発生し、2つの異なる輸送過程が細胞内で混在すると考えられる。

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  • Mechanical memory effect of cells in colony

    Grant number:18340122

    2006 - 2008

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    KAWABATA Kazushige, HAGA Hisashi, NEMOTO Koji

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    Grant amount:\15940000 ( Direct Cost: \13900000 、 Indirect Cost:\2040000 )

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  • 細胞システムにおける「力学平衡」モデルの実証

    Grant number:15650051

    2003 - 2004

    System name:科学研究費助成事業 萌芽研究

    Research category:萌芽研究

    Awarding organization:日本学術振興会

    川端 和重, 芳賀 永

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    Grant amount:\3000000 ( Direct Cost: \3000000 )

    細胞運動や組織形成などには、基質の伸展刺激や流れずり応力等の力学的刺激が重要な働きをすることが知られている。本研究の目的は、外力に対する細胞の力学的応答を調べることにより、細胞内のアクチンフィラメントネットワークの動的性質を明らかにする、特に、外的刺激に対する力学的な平衡状態(張力ホメオスタシス)の存在およびその性質また分子レベルでの要因を明らかにすることである。本研究により得た結果は以下である。
    1)弾性シャーレを用いて、生きたマウス繊維芽細胞(NIH-3T3)を伸長もしくは収縮させた時の、細胞のかたさ分布の時間変化を力学SPMを用いて測定した。細胞内のアクチンストレスファイバーに働く張力にも恒常性が存在し、元の状態に戻るために2時間程度の時定数を持つ。2)ストレスファイバーの収縮力の起源であるミオシン調節軽鎖(MRLC ; Myosin Regulatory Light Chain)に結合したリン酸数と張力の応答の関係を調べた。1リン酸化はできるが2リン酸化することが出来ないMRLC(MRLC-T18A)を過剰に発現させた細胞を機械的に伸張させ、その力学的応答をSPMによって測定した。この細胞では細胞内張力ホメオスタシスは起こらない。3)wild-type細胞を伸長もしくは収縮し、リン酸化されたMRLCの細胞内の空間分布を共焦点蛍光顕微鏡で観察した。細胞の伸長直後にストレスファイバー上に2リン酸化したMRLCが増大し、その後脱リン酸化が進み、120分後には伸長前の状態に戻った。また、細胞を収縮させると、収縮直後に1リン酸化したMRLCが減少し、その後リン酸化が進み、数十分後には収縮前の状態に戻った。2)-3)の結果から、細胞の定常状態におけるMRLCは1リン酸化状態をとり、外部からの伸長によって大きな細胞内張力が必要になれば2リン酸化状態、収縮によって細胞内張力が不要になれば脱リン酸化状態をとると考えられる。すなわち、細胞内張力の安定化機構はMRLCに結合したリン酸の数によって制御されていることが明らかになった。

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  • Creation of Soft & Wet Artificial Muscles and Their Application as Biomotion Systems

    Grant number:14GS0301

    2002 - 2006

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Creative Scientific Research

    Research category:Grant-in-Aid for Creative Scientific Research

    Awarding organization:Japan Society for the Promotion of Science

    OSADA Yoshihito, GONG Jian Ping, YASUDA Kazunori, YAGI Toshirou, YAMAMOTO Masafumi, KAWABATA Kazushige

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    Grant amount:\686400000 ( Direct Cost: \561120000 、 Indirect Cost:\125280000 )

    (I) Synthesis of hydrogel as soft and wet artificial muscles
    By introducing the double network structure into hydrogel, we succeeded in obtaining the hydrogel with extra-ordinary high mechanical toughness (Fracture strength of about several Mpa).
    In addition, by changing the inhomogeous structure of the first network from several 10nm to micrometer, we succeeded in controlling the mechanical behavior of the DN gel from brittle-like to ductile-like. The ductile-like DN gel exhibits an elongation as high as 20 times before failure. To apply this gel as artificial cartilage, we further introduced the graft structure to the DN gel surface and succeeded in obtaining the gel with a fracture stress of several 10MPa, fracture energy of 1000 J/cm^2, and sliding friction coefficient of 10^<-5>〜10^<-4>.
    (II) Application of hydrogel as substitutes of bio-organs
    To apply the gel with excellent mechanical properties as artificial cartilage, wear property, bio-durability and biocompatibility were investigated. Several kinds of DN gels sustained cyclic pin-on-flat test for one million times with a total sliding distance of 50 km, and showed a wearing rate of 10^<-8>-10^<-7>mm^3/Nm. This wear resistance is higher than that of the high density polyethylene (wearing rate of 10^<-7>mm^3/Nm).
    Implantation test of DN gel in the rabbits showed that among several kinds of DN gels, the PAMPS/PDMAAm DN gel was the most suitable for bio-durability. Moreover, it was found that the gel showed a good biocompatibility when artificial cartilage made of PAMPS/PDMAAm was implanted in the articular joints of rabbits.
    Furthermore, we discovered that normal cartilage was regenerated in situ when the PAMPS/PDMAA gel was imbedded into the articular joint several mm from the surface as artificial cartilage. This great discovery will lead to a completely new method to repair the damaged cartilage in situ.

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  • Quantitative evaluation of visco-elastic distribution of living cells using scanning probe microscopy

    Grant number:14550222

    2002 - 2003

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    HIRAI Yoshihiko, KAWATA Hiroaki, KIKUTA Hisao, TANAKA Yoshio, HAGA Hisashi, KAWABATA Kazuhshige

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    Grant amount:\3600000 ( Direct Cost: \3600000 )

    Understanding cellular migration as an integrated mechanical system requires an experimental investigations on mechanical properties of living cells. Force modulation mode with SPM is proposed as a useful method fur measuring stiffness of living cells with high temporal and spatial resolution. However, in liquid environment, cellular stiffness obtained by force modulation mode is often incredible.
    To clear this problem, numerical analysis of the 1-dimensional dynamic equation of a-micro cantilever, which concern about the visco-elastic property of the sample and viscosity of the liquid, is carried out to evaluate the relations between phase shift and amplitude modulations when the cantilever contacts with the living cells in a liquid. Also, the vibration analysis is performed when the cantilever periodically contact and not contact to the sample for various visco-elastic samples. Based on those results, the quantitative relations between vibration property of the cantilever and visco-elastic property of the sample are derived. Using these results, analysis system of the visco-elastic property for living cells is newly developed and the mechanical property of the living cells are demonstrated.

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  • in vivo Dynamics of filamin A-crosslinked actin-based cytoskeletons and function of their mechanical responses

    Grant number:14580695

    2002 - 2003

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    ITO Tadanao, YAMAZAKI Masahito, OHASHI Kazuyo, KAWABATA Kazushige

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    Grant amount:\3600000 ( Direct Cost: \3600000 )

    (1) Filamin A (FLNa) organizes actin filaments into 3-D orthogonal networks in cell cortex. In this study, to clarify the role of FLNa in cell movement, we directed our attention to the cell mobility and the cell stiffness by comparing FLNa-deficient human melanoma cells (M2) and MZ sub-line expressing FLNa (A7). The cellular movement was observed for several days by using phase contrast microscopy equipped with an incubational system. Based on the statistical analysis, we found that A7 cells had much higher mobility compared with M2 cells. The cellular stiffness was measured by using Mechanical Scanning Probe Microscopy (M-SPM), which can provide us spatial distribution of elasticity in a sub-micrometer resolution. The cellular stiffness of A7 cells was about 5.5 kPa, which was more than twice that of M2 cells (2.2 kPa). In according to our previous study, the degree of stiffness imaged by the M-SPM corresponds to the intracellular tension acting along the stress fibers. Therefore, the intracellular tension in A7 cells produces larger traction force to the substrate, and causes higher mobility compared with M2 cells. Furthermore, immunofluorescent observation revealed that A7 cells formed the stress fibers while M2 cells did not, indicating M2 cells were not able to form the distinct stress fibers. Our results suggest that FLNa not only forms actin gels but also stabilizes the stress fibers, and increases the cell mobility and stiffness.
    (2) Actin-based cytoskeleton responds to osmotic stress across a cell membrane so as to keep the cell volume constant. No conventional theory could account for this phenomenon. We have analyzed it with formulating the entropy of the system under the osmotic stress, and showed for the first time that the Le Chatelier principle governs such response of actin-based cytoskeleton to osmotic stress.

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  • 摩擦の物理

    Grant number:13894010

    2001

    System name:科学研究費助成事業 基盤研究(C)

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    松川 宏, 鈴木 勝, 前田 京剛, 川端 和重, 那須野 悟, 三浦 浩治

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    Grant amount:\3400000 ( Direct Cost: \3400000 )

    内部に多くの自由度を持つ巨視的な系に外力を加えた場合、広義の摩擦を伴う複雑な運動を示すことがある。これに関した現象は固体界面の滑り摩擦から地震、電荷密度波、磁束格子など電子の巨視的凝縮相でのある種の秩序の運動など様々な分野の広いスケールに渡る。本研究では、研究代表者、分担者による周到な準備のもと、8月20〜22日に大阪大学豊中キャンパスにおいて、異なる分野、異なるスケールにわたる広義の摩擦現象に関する実験研究者と理論研究者が集まり、これらの現象を総合的に議論し分野間の交流を深める研究会"摩擦の物理"を開催した。80名ほどの参加者を得て、活発な議論が行われたた。これらの活動を通じて、"摩擦の物理"に関する研究グループが形成され、その後、数回の話しあいを経て、明確な将来の研究計画が立てられた。そして11月には科学研究費補助金特定領域研究"摩擦の物理"の申請へと結実した。この研究組織は総括班と7つの計画研究班からなり、以下のことを目的としている。
    本研究は、現代物性科学・技術の成果をもとに新しい視点から、工学を含めた様々な分野における多様な系・レベルの摩擦機構の研究を有機的に繋げ、ミクロスケールからマクロスケールにわたる現象の階層性を正しく取り込み、摩擦の基礎的機構を統一的に解明する。摩擦の普遍性と個別性を明かにし、物理科学の新しい概念を生み出すとともに、その成果を踏まえた新たな摩擦制御技術の創生を目指す。

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  • 強弾性結晶内の孤立ドメイン境界が示す1次元運動における断続性の精密測定

    Grant number:11874043

    1999

    System name:科学研究費助成事業 萌芽的研究

    Research category:萌芽的研究

    Awarding organization:日本学術振興会

    川端 和重, 三本木 孝

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    Grant amount:\1700000 ( Direct Cost: \1700000 )

    有機単結晶(TMTSF)_2Xは外力の下で孤立した双晶境界を生じ、その運動がリアルタイムで観察できることを私たちは見いだし、その運動を詳細に調べている。本研究では、特に、この観察から発見した一定応力下における運動の断続性に焦点を当て、その起源を明らかにするために、一旦停止時間の性質を調べた。以下に主な結果を記す。
    1)一旦停止は結晶内に固定された場所において起こる。このため、結晶内の欠陥や転位などの格子系に固定した乱れが起源と考えられる。2)外的条件(応力、温度、待機時間)を一定に制御して繰り返し実験を行うと、一旦停止がおこる直前の局所的速度は一定であるにも関わらず、その直後の停止時間は100倍以上も揺らぐ。局所的な速度が一定であることは、この結晶の外的環境が一定であることを保証していることから、一旦停止の時間は運動とは異なる支配要因によるものであるといえる。すなわち、一旦停止状態は単純に速度の遅い極限状態ではないといえる。3)揺らいだ停止時間の平均植は応力、待機時間とともに速度と同様の依存性を示す。このことから、停止時間は運動状態と同様の外力による影響を受けているといえる。4)停止時間のゆらぎは対数正規分布をしており、その分布関数は応力及ぴ待機時間には依存せず一定であった。
    これらの結果から、結晶内に固定したピンニングセンターにおいて境界は停止し、熱励起によってこのポテンシャルを乗り越えて運動を再開すると考えられる。このピンニングポテンシャルは、境界の反対方向の運動によって平均値の回りに揺らぎ、その結果として停止時間が対数正規分布で揺らぐことが理解できる。ただし、ピンニングポテンシャルの実体および揺らぐメカニズム、およびその揺らぎが外力によって不変である理由については境界に関するミクロな情報を得る研究が必要である。

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  • Chaotic motion of twin boundary in organic single crystals.

    Grant number:08455048

    1996 - 1997

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    KAWABATA Kazushige, ONODERA Akira, NEMOTO Kouji

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    Grant amount:\7600000 ( Direct Cost: \7600000 )

    Structure and dynamics of twin boundaries in (TMTSF) _2PF_6 were studied. From microscopic observations, they are planar in shape and their width is less than 10 nm. No change in their shape was found. Their movement and pair annihilation do not leave any trace in the crystal surface. The twin boundary shows complex motion under controlled external force. The twin boundary moves intermittently and its velocity varies from run to run though same measurement was repeated under the same force and within the same area of the crystal. When position dependent velocity of the twin boundary is normalized by the average velocity in each run, the normalized curves coinside each other. This result means that the complex motion is subject to two characteristic factors ; one determines the pattern of motion and the other does the magnitude of average velocity. The main factor on variety of motions among repeated runs is found "waiting time" how long the time passes after the boundary went through the point. As the waiting time increases, the average velocity decreases. This result means that the motion includes an aging phenomena not on the boundary but on the crystal.

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  • Cooperative phenomena of living cell systems (Cell migration, Mechanical effects,tissue organization), Friction of the gels (Ageing, Static friction)

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    Grant type:Competitive

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  • 生命活動における力学的協同現象(細胞運動、細胞集団運動、組織化)、多自由度系におけるマクロスケールにあらわれる複雑な運動の研究(ゲル摩擦)

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    Grant type:Competitive

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