Updated on 2024/04/27
医学 ( 2015.3 兵庫医科大学 )
顎骨再建
顔面神経麻痺
頭蓋顎顔面外科
Life Science / Plastic and reconstructive surgery / 再建外科
Niigata University Associate Professor
2018.11
Country：Japan
Hyogo College of Medicine Lecturer
2017.4 - 2018.10
Country：Japan
Hyogo College of Medicine Assistant Professor
2011.4 - 2017.3
Country：Japan
Niigata University Graduate School of Medical and Dental Sciences Biological Functions and Medical Control NephrologyFunctional Neuroscience Associate Professor
2018.11
Osaka University Faculty of Medicine Medical School
1998.3 - 2004.3
Country： Japan
Hyogo College of Medicine 大学院 医科学専攻 生体再生制御系 形成外科学
2011.4 - 2015.3
日本形成外科学会
日本マイクロサージャリー学会
日本頭蓋顎顔面外科学会
日本シミュレーション外科学会
日本頭頸部癌学会
日本顔面神経学会
日本乳癌学会
日本乳房オンコプラスティックサージャリー学会
日本口腔腫瘍学会
Doctor
日本形成外科学会専門医
日本頭蓋顎顔面外科学会専門医
日本形成外科学会皮膚腫瘍外科分野指導医
日本形成外科学会再建・マイクロサージャリー分野指導医
Land Special Radio Engineer (1-3 class)
日本口腔腫瘍学会賞
2020.1 日本口腔腫瘍学会 Free Medial Sural Artery Perforator Flapによる舌半側切除症例の再建
曽束洋平
英語なし
2021.12 Japanese Society for Reconstructive Microsurgery
人工知能を用いた顔面神経麻痺の客観的主観評価システムの確立
Grant number：22K09853
2022.4 - 2026.3
System name：科学研究費助成事業
Research category：基盤研究(C)
Awarding organization：日本学術振興会
松田 健, 奥田 修二郎, 曽束 洋平
Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）
マウス末梢神経損傷・再建術モデルを用いた機能回復機序の解明
Grant number：22K09877
2022.4 - 2025.3
System name：科学研究費助成事業
Research category：基盤研究(C)
Awarding organization：日本学術振興会
若槻 華子, 曽束 洋平
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
Microsoft Kinect V2 as an alternative grading system for facial paralysis
Grant number：17K17039
2017.4 - 2020.3
System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Research category：Grant-in-Aid for Young Scientists (B)
Awarding organization：Japan Society for the Promotion of Science
Yohei Sotsuka
Grant amount：\3250000 （ Direct Cost: \2500000 、 Indirect Cost：\750000 ）
Grading systems for evaluating facial movements in facial paralysis can be classified into traditional and computer-based grading systems. Traditional systems are subjective systems, and the results can only be approximate. Computer-based grading systems provided quantitative repeatable results, they required significant time for manually using software and required high cost which limited their widespread clinical use. Recently, three-dimensional depth cameras in commercial gaming systems have been common, and reduced their cost. This study presents the results of using Microsoft Kinect V2 sensor for grading facial paralysis.
The facial grading system software was implemented using Kinect for windows SDK 2.0. The software program was written by the author in Visual C#.
For facial paralysis patient with synkinesis, after the botulinum toxin injections, the synkinetic eye closure movements improved both clinically and also in our facial grading system software.
Analysis of nerve regeneration in a hybrid artificial nerve containing basic-FGF
Grant number：16K11391
2016.4 - 2020.3
System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Research category：Grant-in-Aid for Scientific Research (C)
Awarding organization：Japan Society for the Promotion of Science
Kakibuchi Masao
Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）
To develop hybrid artificial nerve conduits, biodegradable artificial nerve conduits made from woven polyglycolic acid (PGA) filled with collagen fibers were used. Gelatin hydrogel containing basic fibroblast growth factor (bFGF) and adipose-derived stem cells (ASCs) was put into PGA-collagen tube. Some lateral holes were made on the tube and condition of the gelatin hydrogel and artificial nerve ware observed.In clinical cases, artificial nerves were applied to nerve gaps of peroneal nerve without any complications. Autologous nerve grafts were used in facial nerve, hypoglossal nerve and recurrent laryngeal nerve. Comprehensive surgical treatment of facial paralysis including facial nerve reconstruction, nerve crossover and static procedures was analyzed.
Grant number：16K15755
2016.4 - 2018.3
System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
Research category：Grant-in-Aid for Challenging Exploratory Research
Awarding organization：Japan Society for the Promotion of Science
Kawai Kenichiro
Grant amount：\3380000 （ Direct Cost: \2600000 、 Indirect Cost：\780000 ）
Hypertrophic Scar is a condition where high accumulation of collagen can be seen which is promoted by the excessive wound healing process. Main factors causing hypertrophic scar are (1). stretching force of wound site and (2). inflammation of wound. Although we tried to investigate the interaction between fibroblasts and dendritic cells under stretched condition, the research did not work well. However, meanwhile, we found the interaction between keratinocyte and fibroblasts under cyclic stretched condition. It is known that keratinocytes secret Endothelin-1 in response to the stretching force. In our study, cyclic stretching force is found to enhance the expression of Endothelin Receptor B and its coupling ion channel; TRPC3 and the sensitivity to Endothelin -1 signaling is increased. These findings suggest that the interaction between fibroblasts and keratinocytes during the wound healing process contribute to the formation of hypertrophic scar.
Analysis of facial nerve regeneration in end-to-side neurorrhaphy
Grant number：25462807
2013.4 - 2016.3
System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Research category：Grant-in-Aid for Scientific Research (C)
Awarding organization：Japan Society for the Promotion of Science
Kakibuchi Masao, NISHIMOTO So, KAWAI Kenichiro, SOTSUKA Yohei
Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）
In 10 rabbits, four branches of facial nerve were experimentally sectioned and reconstructed with cable grafts and end-to-side nerve graft with epineural suture and partial neurectomy. Morphological investigation showed that regenerating axons of the facial nerve trunk regenerate into each distal branches.
The technique was applied in 3 patients and satisfactory functional recovery was obtained.
Healing response of the bone following laser osteotomy
Grant number：24791929
2012.4 - 2014.3
System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Research category：Grant-in-Aid for Young Scientists (B)
Awarding organization：Japan Society for the Promotion of Science
SOTSUKA Yohei
Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）
We have compared the histological appearance of bone ablation and healing response in rabbit radial bone osteotomy created by surgical saw and ytterbium-doped fiber laser controlled by a computer and manually. The output power of the laser was 60W at the scanning speed of 20mm/sec scan using continuous wave system. Bone osteotomy was performed by an ytterbium-doped fiber laser and a surgical saw. Additionally, histological analyses of the osteotomy site were performed on day 0 and day 21. Ytterbium-doped fiber laser osteotomy revealed a remarkable cutting efficiency. Lased specimens have shown no delayed healing compared with the saw osteotomies. The output power of the laser was 20W and 30W using continuous wave system with a manual ablation. Those osteotomies revealed also a remarkable cutting efficiency.
