Grant amount：\16120000 （ Direct Cost: \12400000 、 Indirect Cost：\3720000 ）

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Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

No care has been established for skin damage caused by irradiation that is adapted to the mechanism of radiation damage. Therefore, the current situation is that the skin becomes dry, and conventional moisturizers are applied to the skin. In radiation-induced skin damage, cells Therefore, skin damage persists for a long period of time. Therefore, not only moisturizing effects but also antioxidant and cell repair effects are required for skin cells. Cocoons have been used. We found that green cocoons, which contain a large amount of flavonoids, are particularly effective.

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Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

Effects of nursing by foster-mothers on formation and maturation of brain were investigated morphofunctionally using rats. Effcts of foster-mothers on recovery from acute arrest stress loaded in the age of puberty.
The number of neurons immunoreactive to corticotropin-releasing factor (CRF neurons) in the bed nucleus of the stria terminalis, paraventricular hypothalamic nucleus and amygdaloid nucleus were decreased in the rats that were nursed by the foster-mothers with an experience in nursing of their own babies. On the other hand, the number of CRF neurons after acute arrest stress were increased.
The findings suggest a possibility that nursing by the experienced foster-mothers has some effects on formation and maturation of brain. It is necessary to judge inclusively nursing by other kinds of foster-mothers. Further investigations concerning other brain region and neurochemical substanses are also required.

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Grant amount：\2340000 （ Direct Cost: \1800000 、 Indirect Cost：\540000 ）

Repeated irradiation risks causing inflammation and radiation skin ulcers. A new method of care was examined to safely relieve symptoms without leaving residues at the irradiation site. A skin burn model resembling a skin irradiation model was prepared and various methods care ware examined. In the acute phase immediately after injury, the moisture content has been found to decrease on repeated washing with ordinary detergent, but the converse situation has been seen repeated washing with cold- process soap. Such essential oils must be of a type that is effective for epidermal regeneration in the skin.

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