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Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)  

The purpose of this study was to elucidate nursing students' experiences of nursing skills during clinical practice in the nursing program at Niigata University. By clarifying these experiences via a factual investigation, we can obtain an evaluation of nursing practice skills, which is one of the sub-concepts of the program, “field-specific skills.” Our survey was based on the content of the “Learning Status of Nursing Skills List.” This list is unique to our university, and we surveyed the graduating seniors based on the list. The nursing skills that all 70 students were able to perform in clinical practice were “wheelchair transfer,” “wiping clean,” and “vital sign measurement.” The most common nursing skill that the students wished they had more experience with before graduation was “skin/muscle/vein injection.” In terms of the students' subjective perceptions, 23(32.9%) answered that they had had “many opportunities” to experience nursing skills in their clinical practice during the four years of the program, and 50(71.4%) wished to have “opportunities to strengthen their skills before graduation.” Future educational issues include the need for further enhancement of on-campus exercises and opportunities to strengthen students' skills before graduation.

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Other Link： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19636/

Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

The cystine/glutamate antiporter, system xc- , is essential for the efficient uptake of cystine into cells. Interest in the mechanisms of system xc- function soared with the recognition that system xc- presents the most upstream node of ferroptosis, a recently described form of regulated necrosis relevant for degenerative diseases and cancer. Since targeting system xc- hold the great potential to efficiently combat tumor growth and metastasis of certain tumors, we disrupted the substrate-specific subunit of system xc- , xCT (SLC7A11) in the highly metastatic mouse B16F10 melanoma cell line and assessed the impact on tumor growth and metastasis. Subcutaneous injection of tumor cells into the syngeneic B16F10 mouse melanoma model uncovered a marked decrease in the tumor-forming ability and growth of KO cells compared to control cell lines. Strikingly, the metastatic potential of KO cells was markedly reduced as shown in several in vivo models of experimental and spontaneous metastasis. Accordingly, survival rates of KO tumor-bearing mice were significantly prolonged in contrast to those transplanted with control cells. Analyzing the in vitro ability of KO and control B16F10 cells in terms of endothelial cell adhesion and spheroid formation revealed that xCT expression indeed plays an important role during metastasis. Hence, system xc- emerges to be essential for tumor metastasis in mice, thus qualifying as a highly attractive anticancer drug target, particularly in light of its dispensable role for normal life in mice.

DOI： 10.1002/ijc.33262

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Language：English   Publishing type：Research paper (scientific journal)  

Symptom burden and health-related quality of life (HRQOL) are important predictors of how a disease affects patients' lives, especially for endemic health problems such as chronic kidney disease of uncertain etiology (CKDu). Our study describes symptom burden, HRQOL, and associated demographic and clinical variables in CKDu patients in the Girandurukotte area, Sri Lanka. A cross-sectional study included 120 CKDu patients attending the renal clinic in the endemic area. The instruments applied were the Kidney Disease Quality of Life-Short Form (KDQOL-SFTM) version 1.3 and CKD Symptom Index-Sri Lanka. Socio-demographic, disease-related, and anthropometric variables were also investigated. The mean age of patients was 61.87 (SD 11.31), while 69.2% were male. The mean glomerular filtration rate was 28.17 (SD 14.03) mL/min/1.73 min2, and 70.8% were anemic. Bone/joint pain was the most experienced symptom while the median number of symptoms reported by patients was 5 (IQR 3-7). The mean symptom burden, physical component summary, mental component summary, and kidney-disease-specific component scores were 12.71 (SD 10.45), 68.63 (SD 19.58), 78.53 (SD 18.78), and 81.57 (SD 5.86), respectively. Age was found to be a significant predictor of HRQOL, while hemoglobin level and being a farmer were significant predictors of symptom burden. Our data indicate that CKDu patients in all stages experience at least one symptom affecting all aspects of HRQOL.

DOI： 10.3390/ijerph17114041

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Language：Japanese   Publisher：新潟大学医学部保健学科  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2020&ichushi_jid=J06421&link_issn=&doc_id=20200507530003&doc_link_id=2001275&url=https%3A%2F%2Fkango-sakuin.nurse.or.jp%2Fcompany%2Fnid%2F2001275&type=%E6%9C%80%E6%96%B0%E7%9C%8B%E8%AD%B7%E7%B4%A2%E5%BC%95Web&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00014_1.gif

Authorship：Lead author,　Corresponding author   Language：Japanese  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2017&ichushi_jid=J06462&link_issn=&doc_id=20170803310001&doc_link_id=10.24462%2Fjnse.4.2_90&url=https%3A%2F%2Fdoi.org%2F10.24462%2Fjnse.4.2_90&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(一社)日本アロマセラピー学会  

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: To clarify the interaction between adipose tissue stromal cells and bladder cancer cells. METHODS: Superficial (RT4) and invasive (EJ) urothelial carcinoma cells were cultured on adipose tissue stromal cell-embedded or non-embedded collagen gel. Cells were analyzed by immunohistochemistry, western blot and real-time reverse transcription polymerase chain reaction. RESULTS: Adipose tissue stromal cells inhibited growth of RT4, while they promoted the apoptosis. In contrast, adipose tissue stromal cells promoted growth of EJ, but they did not affect the apoptosis. Adipose tissue stromal cells slightly promoted expression of mitogen-activated protein kinase cascade in RT4 and EJ. Adipose tissue stromal cells promoted display of the molecular-targeted agent human epidermal growth factor receptor-2 in only RT4. In turn, RT4 and EJ enhanced α-smooth muscle actin (myofibroblast marker) and S-100 protein (adipocyte marker) expression of adipose tissue stromal cells, respectively. CONCLUSIONS: These findings suggest that: (i) adipose tissue stromal cells might suppress the progression of superficial-type cancer, whereas they might promote that of invasive type; (ii) adipose tissue stromal cell-activated mitogen-activated protein kinase pathway might play differential roles in both types of bladder cancer; (iii) human epidermal growth factor receptor-2 could represent a critical therapeutic agent for the superficial type under adipose tissue stromal cells-cancer interaction; and (iv) superficial bladder cancer might promote myofibroblast differentiation of adipose tissue stromal cells as a cancer-associate phenotype, whereas invasive bladder cancer might promote their adipocyte differentiation.

DOI： 10.1111/iju.13086

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(一社)日本アロマセラピー学会  

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Language：English   Publishing type：Research paper (scientific journal)  

Esophageal squamous cell carcinoma (ESCC) develops within the squamous epithelial layer and invades the submucosa to the subadventitia that has adipose tissue (AT). AT seems critical to ESCC progression, but the underlying mechanism is unknown. We aimed to address the association between ESCC and AT in vitro. ESCC cells were cultured on rat or human subcutaneous AT-embedded or -non-embedded collagen gel. AT promoted the growth of ESCC cells and inhibited their apoptosis. AT promoted the expression of the squamous differentiation marker involucrin in ESCC cells. AT accelerated the expression of invasion-related factors in poorly differentiated ESCC cells only. AT promoted the expression of phosphorylated-insulin-like growth factor-1 receptor in ESCC cells, whereas it inhibited that of the human epidermal growth factor receptor 2. Insulin-like growth factor-1, but not leptin, adiponectin, or resistin, promoted and inhibited the growth and apoptosis of ESCC cells, respectively. In turn, ESCC cells decreased the production of these adipokines in AT and the number of preadipocytes and mesenchymal stem cell-like cells, which developed from AT. These results suggest that i) AT may influence the progression of ESCC with increased growth or invasion and decreased apoptosis through insulin-like growth factor-1/insulin-like growth factor-1 receptor signaling, ii) AT may affect human epidermal growth factor receptor 2-targeted therapy; and iii) the cancer cells may affect adipokine production in AT.

DOI： 10.1016/j.ajpath.2016.01.003

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Language：English   Publishing type：Research paper (scientific journal)  

Adipose tissue (AT)-thyrocyte interaction is largely unknown. Here we described the interaction in a co-culture system, in which thyrocytes were cultured on AT fragment (ATF)-embedded collagen gel, using electron microscopy, immunocytochemistry, real-time reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). ATFs promoted the hypertrophy, polarization and lipid accumulation of thyrocytes. ATFs did not affect the growth of thyroyctes, and inhibited their apoptosis. ATFs increased the protein expression of thyroglobulin (Tg) and paired box gene 8 (PAX8) in thyrocytes. In turn, thyrocytes decreased the concentration of leptin and adiponectin, and increased the expression of these mRNAs in ATFs. Thyrotropin (TSH) enhanced the ATF-induced nuclear hypertrophy and Tg protein expression in thyrocytes, while TSH enhanced the thyrocyte-induced expression of leptin and adiponectin mRNAs in ATFs. Finally, leptin promoted the hypertrophy and Tg protein expression in thyrocytes. TSH enhanced these leptin-induced effects. The data indicate an active interaction between thyrocytes and AT, suggesting that (i) ATFs may serve to regulate the morphology, survival and differentiation of thyrocytes probably through lipid accumulation partly in a TSH-synergistic way; (ii) thyrocytes may affect adipokine production from ATFs in a TSH-independent manner; and (3) leptin may be related to the hypertrophy and differentiation of thyrocytes in a TSH-synergistic way.

DOI： 10.1111/pin.12387

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Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publisher：看護理工学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2024&ichushi_jid=J06462&link_issn=&doc_id=20240802280001&doc_link_id=10.24462%2Fjnse.11.0_234&url=https%3A%2F%2Fdoi.org%2F10.24462%2Fjnse.11.0_234&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(公社)日本生化学会  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本放射線看護学会  

J-GLOBAL

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J-GLOBAL

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Language：Japanese   Publisher：東京 : 日本音響学会  

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I030315092

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Language：Japanese   Publisher：コ・メディカル形態機能学会  

J-GLOBAL

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Language：Japanese   Publisher：(株)日本臨床社  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本アロマセラピー学会  

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Language：Japanese   Publisher：東京法令出版(株)  

J-GLOBAL

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Language：Japanese   Publisher：(株)医学書院  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2015&ichushi_jid=J00269&link_issn=&doc_id=20150130050013&doc_link_id=1501460&url=https%3A%2F%2Fkango-sakuin.nurse.or.jp%2Fcompany%2Fnid%2F1501460&type=%E6%9C%80%E6%96%B0%E7%9C%8B%E8%AD%B7%E7%B4%A2%E5%BC%95Web&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00014_1.gif

Language：Japanese   Publisher：(一社)日本看護技術学会  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本看護技術学会  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本看護技術学会  

J-GLOBAL

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Language：Japanese   Publisher：一般社団法人 日本看護研究学会  

DOI： 10.15065/jjsnr.20130722129

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J-GLOBAL

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