Updated on 2024/10/07

写真a

 
OMINATO JUN
 
Organization
University Medical and Dental Hospital Operation Center Assistant Professor
Title
Assistant Professor
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The Best Research Achievement in Research Career

    • 【Papers】 The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan.  2018.10

    • 【Papers】 The natural course of IgG4-related ophthalmic disease after debulking surgery: a single-centre retrospective study.  2019

Degree

  • 博士(医学) ( 2018.3   新潟大学 )

Research Interests

  • eye lid reconstruction

  • Ocular oncology

  • IgG4 related disease

  • malignant lymphoma

Research Areas

  • Life Science / Hematology and medical oncology  / ocular oncology, malignant lymphoma

  • Life Science / Tumor diagnostics and therapeutics  / ocular oncology

  • Life Science / Ophthalmology  / Ocular oncology, Oculoplastic surgery

Research History (researchmap)

  • Niigata University   Medical and Dental Hospital

    2021.7

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    Country:Japan

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  • Niigata University   Medical and Dental Hospital Ophthalmology   Assistant Professor

    2019.4 - 2021.6

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    Country:Japan

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  • Niigata University   Medical and Dental Hospital Ophthalmology

    2012.4 - 2019.3

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    Country:Japan

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  • 厚生連長岡中央綜合病院   眼科   医員

    2011.4 - 2012.3

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    Country:Japan

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  • 新潟県立中央病院   眼科   医員

    2010.4 - 2011.3

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    Country:Japan

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  • Niigata University   Medical and Dental Hospital Ophthalmology

    2009.4 - 2010.3

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    Country:Japan

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Research History

  • Niigata University   Operation Center, University Medical and Dental Hospital   Assistant Professor

    2021.7

  • Niigata University   University Medical and Dental Hospital Ophthalmology   Assistant Professor

    2019.4 - 2021.6

Education

  • Niigata University   Graduate School of Medical and Dental Sciences   分子細胞医学専攻分子診断病理学分野

    2014.4 - 2018.3

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    Country: Japan

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  • University of Toyama   Faculty of Medicine   School of Medicine

    2001.4 - 2007.3

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    Country: Japan

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Professional Memberships

Committee Memberships

  • Japanese society of ocular oncology   commissioner  

    2019.7   

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    Committee type:Academic society

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Papers

  • 渦静脈浸潤がみられたぶどう膜悪性黒色腫の2例

    安樂 晶子, 大湊 絢, 塩崎 直哉, 張 大行, 福地 健郎, 大橋 瑠子, 谷 優佑

    臨床眼科   76 ( 9 )   1279 - 1285   2022.9

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    Language:Japanese   Publisher:(株)医学書院  

    <文献概要>目的:渦静脈浸潤がみられたぶどう膜悪性黒色腫2症例の経過を報告する。症例1:67歳,女性。右眼内腫瘍の診断で当科を紹介され初診。右眼毛様体付近に腫瘍高12mm大の黒色腫瘤を認めた。ぶどう膜悪性黒色腫と診断し,初診から20日後に眼球摘出術を施行。病理診断はぶどう膜悪性黒色腫で,渦静脈浸潤がみられた。眼球摘出後7ヵ月で結膜下に局所再発を生じたため腫瘤のみを一塊にして摘出し,後療法としてインターフェロンβ(IFN-β)結膜下注射を施行した。眼球摘出後9ヵ月で肝転移が生じ,肝動脈化学塞栓療法および免疫チェックポイント阻害薬(ICI)による加療が行われたが,肝転移診断後7ヵ月で死亡した。症例2:69歳,女性。右眼内腫瘍の診断で当科を紹介され初診。右眼内に腫瘍高8.5mmの黒色腫瘤を認めた。ぶどう膜悪性黒色腫と診断し,初診から13日後に眼球摘出術を施行。術中所見で黒色に変色した渦静脈が認められた。病理診断はぶどう膜悪性黒色腫で,渦静脈として提出した検体にも腫瘍細胞が認められた。後療法としてIFN-β結膜下注射を施行した。眼球摘出後12ヵ月で多発肝転移を生じ,ICIによる加療が行われたが,肝転移診断後12ヵ月で死亡した。結論:ぶどう膜悪性黒色腫の渦静脈浸潤例は局所再発・肝転移の高リスク症例であり,後療法の確立が望まれる。

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  • Evaluation of the postoperative course of East Asian eyelid reconstruction with free tarsoconjunctival graft transplantation: A Japanese single-centre retrospective study. International journal

    Jun Ominato, Tokuhide Oyama, Hiroyuki Cho, Naoya Shiozaki, Koichi Eguchi, Takeo Fukuchi

    JPRAS open   33   6 - 16   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    Although eyelid reconstruction by transplanting an autologous free tarsoconjunctival graft (FTG) is a well-established technique, few studies have examined the postoperative course of FTG transplantation for East Asian eyelids, including those of Japanese patients. Therefore, this study investigated complication and reoperation rates after FTG transplantation in the reconstruction of East Asian (Japanese) eyelids. This study included 42 eyelids wherein posterior lobe reconstruction after resection of a malignant tumour of the eyelid was performed by FTG transplantation between 2007 and 2019 at Niigata University Medical and Dental Hospital. We investigated complications and need for revision surgery during the patients' postoperative courses. The relationship between postoperative complications, tumour diameter, and eyelid defect width was statistically examined. Of 42 cases reconstructed with FTG, the upper eyelid was reconstructed in 23. Postoperative complications were observed in 12 cases (52%): entropion in eight and corneal epithelial disorder in four. Revision surgery was required in three of those cases (13%). There were 19 cases of lower eyelid reconstruction. Postoperative complications were observed in seven cases (32%): ectropion in three and corneal epithelial disorder in two and one lower eyelid ptosis. Two of these cases (11%) required revision surgery. There was no statistically significant difference in tumour diameter between cases with and without postoperative complications. There was also no significant association between the width of the eyelid defect and the presence/absence of complications. Entropion and ectropion were more likely to occur in the upper and lower eyelids, respectively. For Japanese eyelids, complication rates after FTG transplantation were approximately 50% and 30% for the upper and lower eyelids, respectively. The revision surgery rate was approximately 10% for both upper and lower eyelids. As these revision surgery rates are low, FTG transplantation may be an option for the reconstruction of Japanese eyelids.

    DOI: 10.1016/j.jpra.2022.04.003

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  • The natural course of IgG4-related ophthalmic disease after debulking surgery: a single-centre retrospective study. Reviewed International journal

    Jun Ominato, Tokuhide Oyama, Hiroyuki Cho, Naoya Shiozaki, Hajime Umezu, Jun Takizawa, Takeo Fukuchi

    BMJ open ophthalmology   4 ( 1 )   e000295   2019

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Objective: This study aimed to examine the natural course and relapse rate of IgG4-related ophthalmic disease (IgG4-ROD) after debulking surgery in Japanese patients. Methods and analysis: This retrospective review included patients with IgG4-ROD who did not undergo further treatment following debulking surgery. The patients were diagnosed between January 2009 and December 2018 at the Department of Ophthalmology and Pathology, Niigata University Medical and Dental Hospital. The main outcome measures included postoperative IgG4-ROD recurrence rate and differences between patients with and without recurrent disease. Results: Fifteen patients (six male, 9 female; 61.8±16.2 years) were included. Twelve patients (80.0%) had dacryoadenitis disease and three patients (20.0%) had orbital fat tissue disease. About 70%-100% of the lesion was resected in the debulking surgery and the pathological diagnosis was rendered. A definitive diagnosis was made in 13 cases (86.7%) and a probable diagnosis in 2 cases (13.3%). Patients were followed up for 39.0±25.5 months following operation. All patients had lesion volume reduction and patients with dacryoadenitis had eyelid swelling improvement after surgery. Two patients (13.3%) had disease recurrence and six patients (40.0%) had extraophthalmic lesions. There was no statistically significant difference in clinical features between relapsed and non-recurring cases. Conclusion: We observed a 13.3% relapse rate following debulking surgery in patients with IgG4-ROD who did not undergo further treatment. This rate is lower than the documented relapse rate of 30%-70% following oral prednisolone therapy. Therefore, debulking surgery may be a treatment option for IgG4-ROD.

    DOI: 10.1136/bmjophth-2019-000295

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  • The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan. Reviewed International journal

    Jun Ominato, Takeo Fukuchi, Ayako Sato, Naoyuki Yamaguchi, Kazue Kobayashi, Hiroyuki Cho, Tokuhide Oyama, Yoichi Ajioka

    Applied immunohistochemistry & molecular morphology : AIMM   26 ( 9 )   658 - 663   2018.10

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    GNAQ and GNA11 mutations are thought to be important for the tumorigenesis of uveal melanoma. Although previous studies have reported on mutation rates in cases of uveal melanoma, presently, no such report for the Japanese population exists. In this study, we examined the frequency of GNAQ and GNA11 somatic mutations in cases of uveal melanoma in Japan and their relationship with clinicopathologic features or Ki-67-positive cell rates (Ki-67 labeling index: Ki-67 LI) using immunofluorescence methods. The study involved 19 cases of uveal melanoma. We extracted the template DNA from formalin-fixed, paraffin-embedded specimens using a DNA extraction kit. We amplified the DNA sequences of GNAQ and GNA11 using polymerase chain reaction and analyzed mutations by direct sequencing. We evaluated Ki-67 LI using immunofluorescence methods. The frequencies of GNAQ and GNA11 somatic mutations were 26.3% (5/19) and 31.6% (6/19), respectively. The GNAQ and GNA11 mutations were mutually exclusive, as indicated in previous reports. The frequency of GNA11 mutations was significantly higher in epithelioid cells; however, no significant association between GNAQ mutations and cell type was evident, and there was no significant difference in Ki-67 LI between the mutation-positive and mutation-negative tumors. GNAQ and GNA11 mutations were identified in cases of uveal melanoma in Japan, although at lower frequencies than in white counterparts. The mutation frequency of GNA11 was significantly higher in epithelioid cells.

    DOI: 10.1097/PAI.0000000000000505

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  • 眼瞼小腫瘤切除

    大湊絢

    眼科手術   31 ( 2 )   208 - 212   2018.4

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  • 眼窩疾患の内科的アプローチ

    大湊絢, 尾山徳秀

    臨床眼科   72 ( 2 )   196 - 207   2018.2

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  • 眼瞼外反症

    大湊絢

    眼科   59 ( 10 )   993 - 999   2017.10

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  • 再発時CCND1転座陽性となったCD5陽性MALTリンパ腫の1例

    根本 洋樹, 笠見 卓哉, 片桐 隆幸, 河本 啓介, 小林 弘典, 牛木 隆志, 柴崎 康彦, 森山 雅人, 増子 正義, 成田 美和子, 曽根 博仁, 瀧澤 淳, 大湊 絢, 張 大行, 尾山 徳秀, 福地 健郎, 竹内 賢吾, 中村 直哉, 栗田 大輔, 市川 理子, 大島 孝一

    日本リンパ網内系学会会誌   55   104 - 104   2015.6

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    Language:Japanese   Publisher:(一社)日本リンパ網内系学会  

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  • 眼窩壁骨折の硬性再建に対する固定孔なしシート状吸収性プレート(LactoSorb)の使用経験 Reviewed

    尾山徳秀, 張大行, 大湊絢, 福地健郎

    日本形成外科学会会誌   34 ( 10 )   726 - 735   2014.10

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    Language:Japanese  

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  • Reconstruction of the eyelid after excision of primary epithelial malignant tumors Reviewed

    67 ( 8 )   1295 - 1298   2013.8

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    Authorship:Lead author   Language:Japanese  

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    Other Link: http://search.jamas.or.jp/link/ui/2014082135

  • Intravitreal injection of methotrexate was effective in a case of optic disc invasion of systemic malignant lymphoma Reviewed

    Japanese journal of clinical ophthalmology   66 ( 3 )   355 - 360   2012.3

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    Other Link: http://search.jamas.or.jp/link/ui/2012151248

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Books

  • 今日の眼疾患治療指針

    ( Role: Contributor ,  分離腫 母斑症 血管腫)

    医学書院  2022.9  ( ISBN:9784260048071

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    Total pages:xxiii, 1143p   Language:Japanese

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  • 眼病理アトラス

    大湊絢( Role: Contributor ,  視神経膠腫 神経鞘腫 神経線維腫 髄膜腫)

    総合医学社  2020.10  ( ISBN:9784883786886

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    Total pages:xi, 231p   Language:Japanese

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  • 外眼部アトラス

    大湊絢( Role: Contributor ,  神経線維腫)

    総合医学社  2019.10  ( ISBN:9784883786879

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    Total pages:xv, 398p   Language:Japanese

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  • 眼形成手術 : 眼瞼から涙器まで

    大湊絢( Role: Contributor ,  眼窩 対象となる疾患概説,上眼瞼皮膚弛緩,)

    医学書院  2016.11  ( ISBN:9784260028110

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    Total pages:xiii, 459p   Language:Japanese

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  • 知っておきたい眼腫瘍診療

    大湊絢( Role: Contributor ,  眼窩リンパ管腫)

    医学書院  2015.10  ( ISBN:9784260023948

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    Total pages:xiii, 459p   Language:Japanese

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MISC

  • 再発時CCND1転座陽性となったCD5陽性MALTリンパ腫の1例

    根本洋樹, 笠見卓哉, 片桐隆幸, 河本啓介, 小林弘典, 牛木隆志, 柴崎康彦, 森山雅人, 増子正義, 成田美和子, 曽根博仁, 瀧澤淳, 大湊絢, 張大行, 尾山徳秀, 福地健郎, 竹内賢吾, 中村直哉, 栗田大輔, 市川理子, 大島孝一

    日本リンパ網内系学会会誌   55   2015

  • MALTリンパ腫65例の臨床病理学的検討

    瀧澤 淳, 小林 弘典, 柴崎 康彦, 森山 雅人, 増子 正義, 曽根 博仁, 成田 美和子, 大湊 絢, 張 大行, 尾山 徳秀, 福地 健郎, 青木 定夫, 中村 直哉, 大島 孝一

    日本リンパ網内系学会会誌   54   91 - 91   2014.6

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  • MALTリンパ腫65例の臨床病理学的検討

    瀧澤 淳, 小林 弘典, 柴崎 康彦, 森山 雅人, 増子 正義, 曽根 博仁, 成田 美和子, 大湊 絢, 張 大行, 尾山 徳秀, 福地 健郎, 青木 定夫, 中村 直哉, 大島 孝一

    日本リンパ網内系学会会誌   54   101 - 101   2014.6

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  • 高度の視野障害が見られたoptic disc drusenの1例

    上田潤, 大湊絢, 植木智志, 栂野哲哉, 坂上悠太, 五十嵐遼子, 福地健郎, 田沢博

    眼科臨床紀要   6 ( 12 )   2013

Presentations

  • 遊離瞼板結膜移植を用いて後葉再建を行った上眼瞼の術後経過の検討

    大湊絢, 張大行, 尾山徳秀, 江口功一, 福地健郎

    眼瞼義眼床手術学会  2021.2 

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    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 乳がんの転移が疑われた眼窩腫瘍の一例

    大湊絢, 張大行, 中野里絵子, 植木智志, 福地健郎, 利川千絵, 梅津哉

    第53回眼科臨床病理組織研究会  2020 

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  • Local recurrence and lymph node metastasis rates of primary sebaceous and squamous cell carcinoma of the eyelid: A retrospective single institution study.

    Jun Ominato, Naoya Shiozaki, Tokuhide Oyama, Hiroyuki Cho, Takeo Fukuchi

    WOC  2018 

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  • Course of lgG4-related ophthalmic disease following excisional biopsy

    32th Asia Pacific Academy of Ophthalmology congress  2017 

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Awards

  • 新潟県眼科医会奨励賞

    2020.11   The natural course of IgG4-related ophthalmic disease after debulking surgery: a single-centre retrospective study

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  • 新潟県眼科医会学術賞

    2018.7   The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan

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  • 第九回 新潟病理同窓会賞

    2017.5   新潟大学医学部病理同窓会   日本人のぶどう膜悪性黒色腫症例におけるGNAQおよびGNA11変異率と臨床病理学的特徴との関連についての検討

    大湊絢

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Research Projects

  • IgG4関連眼疾患と眼窩MALTリンパ腫合併例の遺伝子および病理学的特徴の解析

    Grant number:22K16944

    2022.4 - 2025.3

    System name:科学研究費助成事業

    Research category:若手研究

    Awarding organization:日本学術振興会

    大湊 絢

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    Grant amount:\2730000 ( Direct Cost: \2100000 、 Indirect Cost:\630000 )

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