Organization
Brain Research Institute Field for Brain Function and Repair Dept. of System Pathology for Neurological Disorders Assistant Professor
Title
Assistant Professor
Contact information
External link
LIU XINYI
Degree
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博士（医学) ( 2017.3 神戸大学 )
Research Interests
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transcranial imaging
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in vivo brain imaging
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skull clearing
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two-photon microscopy
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longitudinal imaging
Research Areas
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Life Science / Basic brain sciences
Research History (researchmap)
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新潟大学脳研究所 システム脳病態学分野 助教
2023.4
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新潟大学脳研究所 システム脳病態学分野 学術振興会外国人特別研究員
2021.4 - 2023.3
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新潟大学脳研究所 システム脳病態学分野 機関研究員
2019.9 - 2021.3
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新潟大学大学院医歯学総合研究科 薬理学分野 特任助教
2019.4 - 2019.8
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神戸大学大学院医学研究科 血管生物学分野 教育研究補佐員
2017.4 - 2019.3
Research History
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Niigata University Dept. of System Pathology for Neurological Disorders, Field for Brain Function and Repair, Brain Research Institute Assistant Professor
2026.4
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Niigata University Brain Research Institute Assistant Professor
2023.4 - 2026.3
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Niigata University Graduate School of Medical and Dental Sciences Specially Appointed Assistant Professor
2019.4 - 2019.9
Education
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神戸大学大学院医学研究科 医科学専攻 博士課程
2011.10 - 2017.3
Papers
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Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain Reviewed
Motokazu Uchigashima, Risa Iguchi, Kazuma Fujii, Kaito Shiku, Pratik Kumar, Xinyi Liu, Mari Isogai, Chiaki Hoshino, Manabu Abe, Motohiro Nozumi, Yosuke Okamura, Michihiro Igarashi, Kenji Sakimura, Ryoma Bise, Luke D. Lavis, Takayasu Mikuni
Nature Communications 16 ( 1 ) 2025.11
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SeeThrough: a rationally designed skull clearing technique for in vivo brain imaging Reviewed International coauthorship
Xinyi Liu, Motokazu Uchigashima, Ikumi Oomoto, Yoshihito Saito, Hitoshi Uchida, Shinya Oginezawa, Keiko Masuda, Daisuke Satoh, Manabu Abe, Kenji Sakimura, Yoshihiro Shimizu, Masanori Murayama, Kazuki Tainaka, Takayasu Mikuni
Nature Communications 16 ( 1 ) 2025.8
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Blood and lymphatic systems are segregated by the FLCN tumor suppressor. Reviewed International journal
Ikue Tai-Nagara, Yukiko Hasumi, Dai Kusumoto, Hisashi Hasumi, Keisuke Okabe, Tomofumi Ando, Fumio Matsuzaki, Fumiko Itoh, Hideyuki Saya, Chang Liu, Wenling Li, Yoh-Suke Mukouyama, W Marston Linehan, Xinyi Liu, Masanori Hirashima, Yutaka Suzuki, Shintaro Funasaki, Yorifumi Satou, Mitsuko Furuya, Masaya Baba, Yoshiaki Kubota
Nature communications 11 ( 1 ) 6314 - 6314 2020.12
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Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1. Reviewed International journal
Xinyi Liu, Akiyoshi Uemura, Yoko Fukushima, Yutaka Yoshida, Masanori Hirashima
Cell reports 17 ( 9 ) 2299 - 2311 2016.11
Research Projects
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A Novel Techniques for In Vivo Neuronal Imaging in the Mouse Brain
Grant number：25K18949
2025.4 - 2027.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Early-Career Scientists
Awarding organization：Japan Society for the Promotion of Science
Authorship：Principal investigator
Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）
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Imaging functional synaptic plasticity during motor learning
Grant number：21F21113
2021.4 - 2023.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for JSPS Fellows
Awarding organization：Japan Society for the Promotion of Science
Grant amount：\2300000 （ Direct Cost: \2300000 ）
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Platelet activation plays a repulsive role of lymphatic to blood vessels in mouse peripheral tissues
Grant number：18K15005
2018.4 - 2020.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Early-Career Scientists
Awarding organization：Japan Society for the Promotion of Science
Liu Xinyi
Authorship：Principal investigator
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
Lymphatic vessels are established as a vasculature separate from blood vessels in peripheral tissues.In this study, we analyzed Phospholipase Cγ2 (Plcg2) knockout mice, which lack platelet activation and show blood-filled lymphatic vasculature. We detected lymph-blood misconnections in embryonic back skin of Plcg2 knockout mice by fluorescent angiography, indicating the role of platelets in the maintenance of lymph-blood partitioning during lymphatic vessel elongation. We also performed time-lapse analysis and found a retraction of LEC protrusion in vitro. These effects were inhibited by an inhibitor of TGF-β signals, while TGF-β induced a retraction of LEC protrusion. In vivo analysis indicates the role of TGF-β in keeping lymphatic vessels separate from blood vessels. These results indicate a novel role for platelets in partitioning blood and lymphatic vascular compartments by promoting LEC retraction in mouse peripheral tissues.
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A novel screen for mouse models of embryonic disease
Grant number：17K19526
2017.6 - 2019.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Challenging Research (Exploratory)
Awarding organization：Japan Society for the Promotion of Science
HIRASHIMA MASANORI, LIU Xinyi, UETA Koji, OGASAWARA Rina
Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）
In this study, we tried to establish an efficient screen for mouse models of embryonic disease. This screening strategy has an advantage in that it does not require breeding of mice that do not show the embryonic phenotype of interest. By using this screen, we searched for novel mouse models and gene mutations causing embryonic edema. Embryonic edema is detected as increased nuchal translucency by ultrasonography in 1% of human pregnancy cases. We have so far investigated more than one thousand mutant mouse embryos. We found 21 and 4 embryos showing edema and eye loss, respectively. This study will contribute in future to the development of early diagnosis using biomarkers and of effective drugs in mouse models.