Updated on 2026/08/13

写真a

 
NONAKA Yukari
 
Organization
Academic Assembly Institute of Medicine and Dentistry - Professor
Faculty of Dentistry Department of Oral Health and Welfare Professor
Graduate School of Medicine, Dentistry and Health Sciences Health Science Professor
Title
Professor
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Degree

  • 博士（歯学） ( 2011.9   新潟大学 )

Research Interests

  • 分子生物学

  • 免疫学

  • 歯周病学

  • 細菌学

Research Areas

  • Life Science / Conservative dentistry  / 歯周病学

Research History

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Professor

    2026.5

  • Niigata University   Dental Educational Research Development, Master's Program of Oral Health and Welfare Science, Graduate School of Medical and Dental Sciences   Professor

    2026.5

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Professor

    2026.4

  • Niigata University   Dental Educational Research Development, Master's Program of Oral Health and Welfare Science, Graduate School of Medical and Dental Sciences   Professor

    2026.4

  • Niigata University   Periodontics, Preventive and Conservative Dentistry, University Medical and Dental Hospital   Lecturer

    2021.10 - 2026.3

  • Niigata University   Graduate School of Medical and Dental Sciences Oral Life Science Oral Biological Science   Assistant Professor

    2019.4 - 2021.9

  • Niigata University   University Medical and Dental Hospital Dental Health Periodontics

    2016.6 - 2017.3

  • Niigata University   University Medical and Dental Hospital Dental Health Periodontics

    2013.8 - 2016.5

  • Niigata University   Graduate School of Medical and Dental Sciences Oral Life Science Oral Biological Science   Researcher

    2011.9 - 2013.7

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Education

  • Niigata University   Graduate School of Medical and Dental Sciences   歯周診断・再建学分野

    2008.4 - 2011.9

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  • Niigata University   Faculty of Dentistry   School of Dentistry

    2001.4 - 2007.3

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Professional Memberships

  • JAPANESE ASSOCIATION FOR DENTAL RESEARCH

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  • NIIGATA DENTAL SOCIETY

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  • International Association for Dental Research

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  • THE JAPANESE SOCIETY OF CONSERVATIVE DENTISTRY

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  • Japanese Society for Evidence and the Dental Professional

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  • 日本再生医療学会

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  • JAPANESE SOCIETY OF PERIODONTOLOGY

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Committee Memberships

  • 特定非営利活動法人 日本歯科保存学会   評議員  

    2025.4   

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  • 特定非営利活動法人 日本歯周病学会   研究委員会  

    2025.4 - 2027.3   

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  • 特定非営利活動法人 日本歯周病学会   選挙管理委員会  

    2025.4 - 2027.3   

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  •   新潟大学特定認定再生医療等委員会  

    2023.10   

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  • 特定非営利活動法人日本歯周病学会   評議員  

    2023.4   

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  • 特定非営利活動法人 日本歯周病学会   編集連絡委員会  

    2022.4 - 2023.3   

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  • 特定非営利活動法人 日本歯周病学会   臨床研修委員会  

    2021.4 - 2025.3   

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Studying abroad experiences

  • アメリカカリフォルニア州立大学サンディエゴ校　医学部免疫教室   博士研究員

    2011.11 - 2013.3

Qualification acquired

  • 日本歯科専門医機構認定　歯周病専門医

  • 日本口腔検査学会　認定医

  • 日本歯科保存学会　歯科保存治療専門医

  • 歯科医師臨床研修指導医

  • Dentist

 

Papers

  • A DPP inhibitor suppresses periodontitis via antibacterial effect targeting Porphyromonas gingivalis

    Yukari Aoki-Nonaka, Yukako Minato, Koushi Hidaka, Yuko Warita, Daiki Ando, Hnin Yu Lwin, Aoi Matsugishi-Nasu, Naoki Takahashi, Akihiro Nakamura, Wataru Ogasawara, Mizuki Sekiya, Yasumitsu Sakamoto, Koichi Tabeta

    Scientific Reports   2026.5

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1038/s41598-026-52648-8

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  • A DPP inhibitor suppresses periodontitis via antibacterial effect targeting Porphyromonas gingivalis. International journal

    Yukari Aoki-Nonaka, Yukako Minato, Koushi Hidaka, Yuko Warita, Daiki Ando, Hnin Yu Lwin, Aoi Matsugishi-Nasu, Naoki Takahashi, Akihiro Nakamura, Wataru Ogasawara, Mizuki Sekiya, Yasumitsu Sakamoto, Koichi Tabeta

    Scientific reports   2026.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    Porphyromonas gingivalis is the most common periodontal pathogen. P. gingivalis dipeptidyl peptidase 7 (PgDPP7) belongs to a new class of serine peptidases, family S46. S46 peptidases are absent in mammals. Therefore, these enzymes are promising targets for novel antibacterial agents. In this study, inhibitors were designed based on the cocrystal structures of valyl-tyrosine and phenylalanyl-tyrosine, which bind to the active centers of DPP7 derived from bacteria, and dipeptide derivatives that inhibit PgDPP7 were obtained. The active compound KGDI-109, the first peptidyl inhibitor of S46 peptidases, exerted an inhibitory effect against P. gingivalis growth at a minimum inhibitory concentration of 1.56 µM. In C57BL/6 N male mice with induced periodontitis, the oral administration of KGDI-109 significantly suppressed alveolar bone resorption and reduced the amount of P. gingivalis in the oral cavity, indicating that the DPP inhibitor suppresses periodontal disease by its antibacterial activity. This dipeptide derivative did not inhibit the growth of other oral bacteria, and its antibacterial action was presumed to target bacteria possessing DPP, particularly P. gingivalis. Furthermore, KGDI-109 may be more effective than azithromycin in maintaining the gut microbial diversity and reducing adverse health effects. KGDI-109 can be a novel treatment for periodontal diseases targeting P. gingivalis.

    DOI： 10.1038/s41598-026-52648-8

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  • The favorable role of recombinant collagen peptide in periosteal cell-derived osteoregeneration

    Tran Thi Thuy Diep, Naoki Takahashi, Takahiro Tsuzuno, Shunya Motosugi, Yuta Ueda, Aoi Yamada, Yukari Aoki-Nonaka, Masaki Nagata, Koichi Tabeta

    Regenerative Therapy   2026.3

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.reth.2026.101064

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  • 米発酵食品の健康機能性について ―歯学部からの取り組み― Invited Reviewed

    岡本圭一郎, 柿原嘉人, 野中由香莉, 多部田康一, 山村健介

    日本醸造協会誌   121 ( 2 )   71 - 79   2026.2

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  • Antimicrobial and antibiofilm effects of a leucine-substituted rice peptide against Porphyromonas gingivalis and Fusobacterium nucleatum Reviewed

    Yukari Aoki-Nonaka, Aoi Matsugishi-Nasu, Hnin Yu Lwin, Yukako Minato, Daiki Ando, Yuko Warita, Naoki Takahashi, Koichi Tabeta

    Microbial Pathogenesis   2025.12

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.micpath.2025.108052

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  • Ferulic acid suppresses Porphyromonas gingivalis biofilm formation via the inhibition of autoinducer-2 production and receptor activity Reviewed

    Daiki Ando, Hnin Yu Lwin, Yukari Aoki-Nonaka, Aoi Matsugishi-Nasu, Yukako Minato, Yuko Warita, Naoki Takahashi, Koichi Tabeta

    Archives of Oral Biology   2025.10

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.archoralbio.2025.106365

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  • Biological stress response to scaling and root planing and subgingival scaling with Er:YAG laser: A pilot study Reviewed

    Takahiro Hokari, Yukari Aoki-Nonaka, Kaname Nohno, Shuntaro Sugihara, Kyoko Arai, Masafumi Yarita, Haruna Miyazawa, Yuko Yamamoto, Tomonori Satoh, Naoki Takahashi, Yasutaka Komatsu, Motohiro Komaki, Koichi Tabeta, Toshiya Morozumi

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)   67 ( 3 )   111 - 121   2025.9

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    Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Periodontology  

    DOI： 10.2329/perio.67.111

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  • ペプチド型ジペプチジルペプチダーゼ阻害剤は歯周炎モデルマウスにおいて歯槽骨吸収を抑制する

    割田 悠子, 野中 由香莉, 湊 裕佳子, 松岸 葵, 安藤 大樹, 多部田 康一, 日高 興士, 阪本 泰光

    新潟歯学会雑誌   55 ( 1 )   23 - 24   2025.7

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    Language：Japanese   Publisher：新潟歯学会  

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  • Enrichment of Porphyromonas gingivalis in colonic mucosa-associated microbiota and its enhanced adhesion to epithelium in colorectal carcinogenesis: Insights from in vivo and clinical studies. Reviewed International journal

    Shunya Motosugi, Naoki Takahashi, Shuhei Mineo, Keisuke Sato, Takahiro Tsuzuno, Yukari Aoki-Nonaka, Nao Nakajima, Kazuya Takahashi, Hiroki Sato, Haruna Miyazawa, Koji Taniguchi, Shuji Terai, Koichi Tabeta

    PloS one   20 ( 3 )   e0320383   2025

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVES: The oral-gut axis is believed to play a role in the pathogenesis of colorectal cancer (CRC). Previous studies have demonstrated the transmission of oral microbiota to the gut, disrupting gut microbial balance and creating a protumorigenic microenvironment conducive to CRC progression. Fusobacterium nucleatum is a putative periodontal pathogen recognized as a specific bacterium that promotes CRC development. However, the possible involvement of other periodontal pathogens in CRC is poorly understood. This study aimed to explore the effects of ingested periodontal pathogens on experimental CRC in mice and elucidate the underlying mechanisms. METHODS: In this study, experimental colitis-induced CRC mouse models were used. The mice were orally administered periodontal pathogens (Porphyromonas gingivalis and Prevotella intermedia) three times a week during the experimental period. The CRC severity between the P. gingivalis-treated and P. intermedia-treated groups was compared. Lumen-associated microbiota (LAM) and mucosa-associated microbiota (MAM) were analyzed in both mouse and human samples. In vitro studies were conducted using intestinal epithelial cells to explore the possible mechanisms by which the periodontal pathogens affect the CRC development. RESULTS: The P. gingivalis-treated group exhibited significantly increased CRC severity compared to the other groups among azoxymethane/dextran sodium sulfate (AOM/DSS)-induced mouse models. The LAM and MAM exhibited distinct bacterial compositions, and P. gingivalis was enriched more in MAM than in LAM. In vitro adhesion assays revealed that P. gingivalis had higher adhesive capacity to intestinal epithelial cells than P. intermedia and indicated the possible involvement of gingipains in such a capacity. CONCLUSION: P. gingivalis is enriched in MAM, and its subsequent adhesion to intestinal epithelial cells is potentially involved in the progression of CRC.

    DOI： 10.1371/journal.pone.0320383

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  • Allyl isothiocyanate suppressed periodontal tissue destruction in mice via bacteriostatic and anti-inflammatory activities against Porphyromonas gingivalis Reviewed

    Yukako Minato, Yukari Aoki-Nonaka, Hnin Yu Lwin, Daiki Ando, Yuko Warita, Aoi Matsugishi-Nasu, Takumi Hiyoshi, Naoki Takahashi, Koichi Tabeta

    Archives of Oral Biology   2024.10

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.archoralbio.2024.106118

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  • Bioinformatic evaluation of the potential oral-gut translocation of periodontal pathogens in patients with colorectal polyps

    Naoki Takahashi, Marin Yamaguchi, Keisuke Sato, Takahiro Tsuzuno, Shuhei Mineo, Nao Nakajima, Kazuya Takahashi, Hiroki Sato, Haruna Miyazawa, Yukari Aoki-Nonaka, Yutaro Ito, Koji Taniguchi, Shuji Terai, Kohei Ito, Koichi Tabeta

    2024.5

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    Publisher：Cold Spring Harbor Laboratory  

    Objective: This study aimed to characterize the profiles of the oral and gut microbiota of patients with colorectal polyps using 16S rRNA gene sequencing and bioinformatic approaches. Background: Previous studies have shown microbial translocation from the oral cavity to the gut, implying pathogenic impacts on gastroesophageal disease, including colorectal cancer (CRC). However, its details remain unclear. Methods: Twenty patients scheduled for endoscopic colorectal polypectomy were enrolled in this study. Oral samples (saliva and subgingival dental plaque) and intestinal samples (feces and swab of intestinal mucosa) were collected during preoperative and 6–month–postoperative reassessment periods. After sequencing the V3–V4 region of the bacterial 16S rRNA gene, several bioinformatic analyses (bacterial composition, diversity, core microbiome, and shared ASV) were performed on pre– and postoperative samples for each subject. Results: The bacterial composition was dominated by Bacteroides, Streptococcus, Fusobacterium, Veillonella, and Prevotella_7 in all four samples. Beta diversity analysis using weighted UniFrac distance distinctly segregated the samples between oral and intestinal environments in the principal coordinate analysis plot. Core microbiome analysis revealed that Streptococcus and Porphyromonas were dominantly shared in intra–oral environments. Additionally, alongside Streptococcus, periodontitis–related bacteria, such as Veillonella, Fusobacterium, Porphyromonas, Prevotella_7, Haemophilus, and Prevotella, were identified as shared genera between oral and intestinal environments. Finally, shared ASV analysis demonstrated that Streptococcus was shared in the oral and intestinal environments of most patients, while periodontal pathogens were shared in some patients. Conclusions: The core microbiome and shared ASV analyses revealed that several genes are shared between oral and intestinal environments in patients with colorectal polyps, indicating the oral–gut translocation of periodontitis–related bacteria. Further large–scale studies are needed to elucidate their involvement in CRC.

    DOI： 10.1101/2024.04.29.591540

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  • 歯周炎患者におけるSRPおよびEr:YAGレーザー応用による歯石除去時の生体応答の検討

    保苅 崇大, 両角 俊哉, 野中 由香莉, 濃野 要, 小松 康高, 杉原 俊太郎, 山本 裕子, 宮沢 春菜, 鎗田 将史, 新井 恭子, 佐藤 友則, 高橋 直紀, 小牧 基浩, 多部田 康一

    日本歯周病学会会誌   66 ( 春季特別 )   140 - 140   2024.4

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    Language：Japanese   Publisher：(NPO)日本歯周病学会  

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  • Characterization of the cellular heterogeneity and bone regenerative potential of cultured human periosteal cells. Reviewed International journal

    Takahiro Tsuzuno, Naoki Takahashi, Masaki Nagata, Yuta Ueda, Shunya Motosugi, Aoi Yamada, Mai Mizuguchi, Tran Thi Thuy Diep, Yukari Aoki-Nonaka, Koh Nakata, Koichi Tabeta

    Regenerative therapy   24   642 - 650   2023.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Cell-based bone regenerative therapy exhibits considerable potential in the treatment of bone defects caused by trauma, disease, and congenital anomalies. The periosteum, a fibrous membrane covering the outer surface of bone, plays a crucial role in bone formation and regeneration by sourcing osteoprogenitor cells. The remarkable osteogenic potential of periosteal cells (PCs) has led to the effective clinical implementation of PC-based regenerative therapies and tissue engineering. The abundance of progenitor cells in cultured PCs is well established; however, the heterogeneity of the cell population and its impact on bone regeneration remain uncertain. In this study, we aimed to characterize the heterogeneity of cultured PCs via single-cell RNA-sequencing (scRNA-seq) and to examine their osteogenic potential in vivo. METHODS: Human PCs cultivated using the tissue explant method were utilized in this study. scRNA-seq and real-time PCR were performed to examine the cellular heterogeneity and osteogenic capacity of the cultured PCs. Experimental bone formation by the cultured PCs was examined using the rat model of subcutaneous implantation. RESULTS: ScRNA-seq analysis showed that the cultured PCs were categorized into three cell types (osteoprogenitor cells, mesenchymal stem cells, and fibroblasts) with specific gene expression patterns. In addition, the cellular population and osteogenic capacity differed between the central and peripheral regions in the culture dish. The PCs in the central region showed higher osteogenic potential than those in the peripheral region. CONCLUSIONS: This study revealed the diversity of the composition of the PCs and their distinct osteogenic capabilities in different regions in the culture dish. The findings may provide promising prospects for the development of more efficacious regenerative therapeutic applications using cultured PCs in the future.

    DOI： 10.1016/j.reth.2023.11.006

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  • Five-year Prognosis and Risk Factor Analysis of Open Flap Debridement for Older People Reviewed

    Yukari Aoki-Nonaka, Takahiro Hokari, Yumi Matsukawa, Keisuke Sato, Miki Hara, Mai Takeuchi, Kei Takamisawa, Kyoko Yamazaki, Takahiro Tsuzuno, Hikaru Tamura, Takumi Hiyoshi, Fumiya Meguro, Emi Hoshikawa, Aoi Matsugishi, Chihiro Kaneko, Shuhei Mineo, Moe Yamashita, Koichi Tabeta

    Operative Dentistry, Endodontology and Periodontology   3 ( 1 )   22 - 34   2023.12

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    Authorship：Lead author,　Corresponding author  

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  • Soybean peptide inhibits the biofilm of periodontopathic bacteria via bactericidal activity Reviewed

    Hnin Yu Lwin, Yukari Aoki-Nonaka, Aoi Matsugishi, Naoki Takahashi, Takumi Hiyoshi, Koichi Tabeta

    Archives of Oral Biology   105497 - 105497   2022.7

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.archoralbio.2022.105497

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  • 歯周病の新分類から考える歯周病の検査・診断ー動向と展望ー

    多部田 康一, 野中 由香莉

    新潟歯学会雑誌   51 ( 2 )   1 - 8   2021.12

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    Language：Japanese   Publisher：新潟歯学会  

    2017年、アメリカ歯周病学会とヨーロッパ歯周病学連盟の合同ワークショップにおいて、歯周病の新しい分類体系が発表された。新分類では、病変の重症度と複雑度をステージ、歯周炎の進行リスクをグレードを用いて評価することが提示された。歯周病のバイオマーカーとして、hCRP(高感度C反応性蛋白質)、PCSK9(プロ蛋白質転換酵素サブチリシン/ケキシン9型)の応用が期待されている。

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  • Rice bran-derived protein fractions enhance sulforaphane-induced anti-oxidative activity in gingival epithelial cells Reviewed

    Shuhei Mineo, Naoki Takahashi, Miki Yamada-Hara, Takahiro Tsuzuno, Yukari Aoki-Nonaka, Koichi Tabeta

    Archives of Oral Biology   105215 - 105215   2021.7

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.archoralbio.2021.105215

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  • Ingestion of Porphyromonas gingivalis exacerbates colitis via intestinal epithelial barrier disruption in mice Reviewed

    Takahiro Tsuzuno, Naoki Takahashi, Miki Yamada-Hara, Mai Yokoji-Takeuchi, Benso Sulijaya, Yukari Aoki-Nonaka, Aoi Matsugishi, Kyoko Katakura, Koichi Tabeta, Kazuhisa Yamazaki

    Journal of periodontal research   56 ( 2 )   275 - 288   2021.4

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  • Rice peptide with amino acid substitution inhibits biofilm formation by Porphyromonas gingivalis and Fusobacterium nucleatum Reviewed

    Aoi Matsugishi, Yukari Aoki-Nonaka, Mai Yokoji-Takeuchi, Miki Yamada-Hara, Yoshikazu Mikami, Manabu Hayatsu, Yutaka Terao, Hisanori Domon, Masayuki Taniguchi, Naoki Takahashi, Kazuhisa Yamazaki, Koichi Tabeta

    Archives of Oral Biology   121   104956   2021.1

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.archoralbio.2020.104956

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  • Epithelial TRPV1 channels: Expression, function, and pathogenicity in the oral cavity. Reviewed International journal

    Naoki Takahashi, Takahiro Tsuzuno, Shuhei Mineo, Miki Yamada-Hara, Yukari Aoki-Nonaka, Koichi Tabeta

    Journal of oral biosciences   62 ( 3 )   235 - 241   2020.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    BACKGROUND: The oral cavity serves as an entrance to the body and is therefore exposed to various exogenous stimuli, including mechanical forces, chemical agents, and bacterial components. The oral mucosa responds to these stimuli to maintain homeostasis and good oral health. The transient receptor potential vanilloid 1 (TRPV1) ion channel functions as an environment-sensing protein and is involved in a wide variety of cellular responses. Recent studies have revealed that epithelial TRPV1 ion channels in the oral cavity play pivotal roles in several pathophysiological conditions. In this review, we summarize the features of epithelial TRPV1 channels in the oral cavity and focus on their cellular function and pathogenicity with reference to related findings in other organs and tissues. HIGHLIGH: t: TRPV1 channels are widely expressed in epithelial cells in the oral cavity and play pivotal roles in fundamental cellular processes and disease progression. CONCLUSION: This review suggests that oral epithelial TRPV1 contributes to several cellular functions such as cell proliferation, barrier function, and inflammation. Further understanding of the characteristics of epithelial TRPV1 in the oral cavity may provide new insights into the prevention or treatment of diseases.

    DOI： 10.1016/j.job.2020.05.005

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  • Nutritional supplements and periodontal disease prevention—Current understanding Reviewed

    Yukari Aoki-Nonaka, Aoi Matsugishi, Hnin Yu Lwin, Naoki Takahashi, Koichi Tabeta

    Current oral health reports   ( 7 )   154 - 164   2020.3

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

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  • A bacterial metabolite induces Nrf2-mediated anti-oxidative responses in gingival epithelial cells by activating the MAPK signaling pathway. Reviewed International journal

    Mai Yokoji-Takeuchi, Naoki Takahashi, Miki Yamada-Hara, Benso Sulijaya, Takahiro Tsuzuno, Yukari Aoki-Nonaka, Koichi Tabeta, Shigenobu Kishino, Jun Ogawa, Kazuhisa Yamazaki

    Archives of oral biology   110   104602 - 104602   2020.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: Oxidative stress, which is defined as an imbalance between pro-oxidant and antioxidant systems, has been implicated in the development and/or progression of several inflammatory diseases, including periodontal disease. The reactive oxygen species (ROS) are the primary inducers of oxidative stress. In the induction of cytoprotective enzymes, the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling in antioxidant systems takes a main role. Notably, 10-oxo-trans-11-octadecenoic acid (KetoC), known as a bioactive metabolite generated by intestinal microorganisms, has been reported to have beneficial effects on several biological responses. Therefore, we investigated the antioxidant effect of KetoC on gingival epithelial cells (GECs) in this present study. METHODS: An SV40-T antigen-transformed human gingival epithelial cell line (Epi4) was used for experiments. The alteration of anti-oxidative stress related genes was analyzed by qPCR. The cellular ROS levels were evaluated by flow cytometry. To explore its molecular mechanisms, ARE promotor activity was analyzed by luciferase assay; the involvement of mitogen-activated protein kinase (MAPK) and G protein-coupled receptor 120 (GPR120) were evaluated by Western blotting and luciferase assay, respectively. RESULTS: KetoC significantly increased the expression of antioxidant-related genes in GECs. The level of ROS was significantly inhibited by the pretreatment of KetoC. Extracellular signal-regulated kinase (ERK) phosphorylation by KetoC promoted both the nuclear translocation of Nrf2 and its binding to the ARE in GECs. Further, GPR120 regulated the activation of KetoC induced-Nrf2-ARE signaling. CONCLUSION: KetoC exerts a protective function against the oxidative stress in GECs through GPR120-dependent ERK-Nrf2-ARE signaling.

    DOI： 10.1016/j.archoralbio.2019.104602

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  • Antimicrobial function of the polyunsaturated fatty acid KetoC in an experimental model of periodontitis. Reviewed International journal

    Benso Sulijaya, Miki Yamada-Hara, Mai Yokoji-Takeuchi, Yumi Matsuda-Matsukawa, Kyoko Yamazaki, Aoi Matsugishi, Takahiro Tsuzuno, Keisuke Sato, Yukari Aoki-Nonaka, Naoki Takahashi, Shigenobu Kishino, Jun Ogawa, Koichi Tabeta, Kazuhisa Yamazaki

    Journal of periodontology   90 ( 12 )   1470 - 1480   2019.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: The bioactive metabolite KetoC, generated by intestinal bacteria, exerts various beneficial effects. Nevertheless, its function in the pathogenesis of periodontitis remains unclear. Here, we investigated the effect of KetoC in a mouse model of periodontitis and explored the underlying mechanism. METHODS: Thirty-one 8-week-old male C57BL/6N mice were randomly divided into four groups (non-ligation, non-ligation + KetoC, ligation + Porphyromonas gingivalis, and ligation + P. gingivalis + KetoC) (n = 7/8 mice/group) and given a daily oral gavage of KetoC (15 mg/mL) or vehicle for 2 weeks. To induce periodontitis, a 5-0 silk ligature was placed on the maxillary left second molar on day 7, and P. gingivalis W83 (109 colony-forming unit [CFU]) was administered orally every 3 days. On day 14, all mice were euthanized. Alveolar bone destruction was determined from the level of the cemento-enamel junction to the alveolar bone crest. Moreover, bone loss level was confirmed from gingival tissue sections stained with hematoxylin and eosin. The presence of P. gingivalis was quantified using real-time polymerase chain reaction. In vitro, the bacteriostatic and bactericidal effects of KetoC were assessed by analyzing its suppressive activity on the proliferation of P. gingivalis and using a live/dead bacterial staining kit, respectively. A double-bond-deficient metabolite (KetoB) was then used to investigate the importance of double-bond structure in the antimicrobial activity of KetoC on P. gingivalis. RESULTS: In vivo, KetoC attenuated alveolar bone destruction and suppressed P. gingivalis in the periodontitis group. In vitro, KetoC (but not KetoB) downregulated the proliferation and viability of P. gingivalis in a dose-dependent manner. CONCLUSIONS: KetoC reduced alveolar bone destruction in a periodontitis model via its antimicrobial function. Therefore, this bioactive metabolite may be valuable in clinical applications to support periodontal therapy.

    DOI： 10.1002/JPER.19-0130

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  • A peptide derived from rice inhibits alveolar bone resorption via suppression of inflammatory cytokine production. Reviewed International journal

    Yukari Aoki-Nonaka, Koichi Tabeta, Mai Yokoji, Aoi Matsugishi, Yumi Matsuda, Naoki Takahashi, Benso Sulijaya, Hisanori Domon, Yutaka Terao, Masayuki Taniguchi, Kazuhisa Yamazaki

    Journal of periodontology   90 ( 10 )   1160 - 1169   2019.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Periodontitis is an inflammatory disease that results in alveolar bone resorption due to inflammatory cytokine production induced by bacterial antigens such as lipopolysaccharides (LPS). Here, the preventive effect of the Amyl-1-18 peptide derived from rice in an experimental model of periodontitis and the effect on the anti-inflammatory response were assessed. METHODS: Alveolar bone resorption, gene transcription of proinflammatory cytokines in the gingiva, and the endotoxin level in the oral cavity were evaluated after oral administration of the Amyl-1-18 peptide for 14 days using a ligature-induced periodontitis model in mice. Additionally, murine macrophages were incubated with LPS of Escherichia coli or Porphyromonas gingivalis in the presence of Amyl-1-18 to analyze the suppressive effects of Amyl-1-18 on the cell signaling pathways associated with proinflammatory cytokine production, including inflammasome activities. RESULTS: Oral administration of Amyl-1-18 suppressed alveolar bone resorption and gene transcription of interleukin (il)6 in the gingiva of the periodontitis model, and decreased endotoxin levels in the oral cavity, suggesting modulation of periodontal inflammation by inhibition of endotoxin activities in vivo. Also, Amyl-1-18 suppressed IL-6 production induced by LPS and recombinant IL-1β in macrophages in vitro but had no effect on inflammasome activity. CONCLUSIONS: The Amyl-1-18 peptide from rice inhibited alveolar bone destruction in mouse periodontitis model via suppressing inflammatory cytokine production induced by LPS. It was suggested that Amyl-1-18 peptide has anti-inflammatory property against LPS, not only by neutralization of LPS and subsequent inhibition of nuclear factor-κB signaling but also by inhibition of the IL-1R-related signaling cascade.

    DOI： 10.1002/JPER.18-0630

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  • The anti-inflammatory effect of 10-oxo-trans-11-octadecenoic acid (KetoC) on RAW 264.7 cells stimulated with Porphyromonas gingivalis lipopolysaccharide. Reviewed

    Sulijaya B, Takahashi N, Yamada M, Yokoji M, Sato K, Aoki-Nonaka Y, Nakajima T, Kishino S, Ogawa J, Yamazaki K

    Journal of periodontal research   53 ( 5 )   777 - 784   2018.4

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    DOI： 10.1111/jre.12564

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  • The TRPA1 ion channel is expressed in CD4+T cells and restrains T-cell-mediated colitis through inhibition of TRPV1 Reviewed

    Samuel Bertin, Yukari Aoki-Nonaka, Jihyung Lee, Petrus R. de Jong, Peter Kim, Tiffany Han, Timothy Yu, Keith To, Naoki Takahashi, Brigid S. Boland, John T. Chang, Samuel B. Ho, Scott Herdman, Maripat Corr, Alessandra Franco, Sonia Sharma, Hui Dong, Armen N. Akopian, Eyal Raz

    GUT   66 ( 9 )   1584 - 1596   2017.9

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    DOI： 10.1136/gutjnl-2015-310710

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  • The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4(+) T cells Reviewed

    Samuel Bertin, Yukari Aoki-Nonaka, Petrus Rudolf de Jong, Lilian L. Nohara, Hongjian Xu, Shawna R. Stanwood, Sonal Srikanth, Jihyung Lee, Keith To, Lior Abramson, Timothy Yu, Tiffany Han, Ranim Touma, Xiangli Li, Jose M. Gonzalez-Navajas, Scott Herdman, Maripat Corr, Guo Fu, Hui Dong, Yousang Gwack, Alessandra Franco, Wilfred A. Jefferies, Eyal Raz

    NATURE IMMUNOLOGY   15 ( 11 )   1055 - 1063   2014.11

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    DOI： 10.1038/ni.3009

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  • The Role of Distinct T Cell Subsets in Periodontitis- Studies from Humans and Rodent Models. Reviewed

    Okui T, Aoki-Nonaka Y, Nakajima T, Yamazaki K

    Curr Oral Health Rep.   1 ( 2 )   114 - 123   2014.6

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  • Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas gingivalis Reviewed

    Y. Aoki-Nonaka, T. Nakajima, S. Miyauchi, H. Miyazawa, H. Yamada, H. Domon, K. Tabeta, K. Yamazaki

    JOURNAL OF PERIODONTAL RESEARCH   49 ( 1 )   69 - 76   2014.2

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    DOI： 10.1111/jre.12080

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  • Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice Reviewed

    Haruna Miyazawa, Koichi Tabeta, Sayuri Miyauchi, Yukari Aoki-Nonaka, Hisanori Domon, Tomoyuki Honda, Takako Nakajima, Kazuhisa Yamazaki

    LIPIDS IN HEALTH AND DISEASE   11   121   2012.9

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    DOI： 10.1186/1476-511X-11-121

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  • Oral infection with Porphyromonas gingivalis and systemic cytokine profile in C57BL/6.KOR-ApoEshl mice Reviewed

    S. Miyauchi, T. Maekawa, Y. Aoki, H. Miyazawa, K. Tabeta, T. Nakajima, K. Yamazaki

    JOURNAL OF PERIODONTAL RESEARCH   47 ( 3 )   402 - 408   2012.6

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    DOI： 10.1111/j.1600-0765.2011.01441.x

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  • Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis Reviewed

    Hirotaka Miyashita, Tomoyuki Honda, Tomoki Maekawa, Naoki Takahashi, Yukari Aoki, Takako Nakajima, Koichi Tabeta, Kazuhisa Yamazaki

    ARCHIVES OF ORAL BIOLOGY   57 ( 6 )   820 - 829   2012.6

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    DOI： 10.1016/j.archoralbio.2011.11.008

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  • The Presence of IL-17(+)/FOXP3(+) Double-positive Cells in Periodontitis Reviewed

    T. Okui, Y. Aoki, H. Ito, T. Honda, K. Yamazaki

    JOURNAL OF DENTAL RESEARCH   91 ( 6 )   574 - 579   2012.6

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    DOI： 10.1177/0022034512446341

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  • Chronic Oral Infection with Porphyromonas gingivalis Accelerates Atheroma Formation by Shifting the Lipid Profile Reviewed

    Tomoki Maekawa, Naoki Takahashi, Koichi Tabeta, Yukari Aoki, Hirotaka Miyashita, Sayuri Miyauchi, Haruna Miyazawa, Takako Nakajima, Kazuhisa Yamazaki

    PLOS ONE   6 ( 5 )   e20240   2011.5

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    DOI： 10.1371/journal.pone.0020240

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  • Analysis of immunostimulatory activity of Porphyromonas gingivalis fimbriae conferred by Toll-like receptor 2 Reviewed

    Yukari Aoki, Koichi Tabeta, Yukitaka Murakami, Fuminobu Yoshimura, Kazuhisa Yamazaki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   398 ( 1 )   86 - 91   2010.7

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    DOI： 10.1016/j.bbrc.2010.06.040

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  • Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease Reviewed

    Tomoyuki Honda, Yukari Aoki, Naoki Takahashi, Tomoki Maekawa, Takako Nakajima, Harue Ito, Koichi Tabeta, Takafumi Okui, Keiko Kajita, Hisanori Domon, Kazuhisa Yamazaki

    CLINICA CHIMICA ACTA   395 ( 1-2 )   137 - 141   2008.9

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    DOI： 10.1016/j.cca.2008.06.003

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Books

  • 歯周治療を適切・安全に行うためのポイントー全身状態への配慮ー

    日本歯周病学会臨床研修委員会

    2023.7 

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  • 歯周病の新分類対応 アップデート・ザ・ペリオ～超高齢社会へのアプローチ～

    （ Role： Contributor ,  2章歯周基本治療 2.治療計画立案）

    株式会社デンタルダイヤモンド社  2023.4  （ ISBN:9784885105579 ）

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  • ザ・ペリオドントロジ― 第4版

    （ Role： Contributor ,  第4章 2歯周病の分類と診断）

    永末書店  2023.2  （ ISBN:9784816014215 ）

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  • よくわかる！口腔バイオフィルムと歯科治療 感染制御のポイントと治療戦略 感染制御のポイントと治療戦略

    野杁由一郎, 久保庭雅恵, 坂中哲人, 竹中彰治, 多部田康一, 野中由香莉, 前薗葉月（ Role： Contributor ,  Ｖ口腔バイオフィルム感染症の臨床現場における位置づけ）

    ヒョーロン・パブリッシャーズ  2022.6  （ ISBN:9784864320719 ）

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  • 歯周基本治療 －進め方とポイントー

    日本歯周病学会 臨床研修委員会  2022.4 

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  • 口腔バイオフィルム感染症の臨床現場における位置づけ－保険収載された口腔細菌定量検査と口腔衛生管理のポイント

    多部田康一, 野中由香莉

    日本歯科評論, 87(7)  2022 

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  • 歯周病およびインプラント周囲組織の疾患と状態に関する新分類 : アメリカ歯周病学会(AAP)/ヨーロッパ歯周病連盟(EFP)共催2017ワールドワークショップ会議録

    Kornman, Kenneth S., Tonetti, Maurizio S., 日本歯周病学会, 日本臨床歯周病学会, 村上, 伸也（全身疾患および先天的あるいは後天的な疾患・状態による歯周組織の徴候：歯周病およびインプラント周囲組織の疾患と状態の分類に関する2017年ワールドワークショップ，ワークグループ３のコンセンサスレポート）

    クインテッセンス出版  2020.10  （ ISBN:9784781207735 ）

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    Total pages：318p   Language：Japanese

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MISC

  • 新規ジペプチド化合物の歯周病原細菌に対する抗菌活性の検討

    割田 悠子, 野中 由香莉, 日高 興士, 阪本 泰光, 湊 裕佳子, 松岸 葵, Lwin Hnin Yu, 安藤 大樹, 多部田 康一

    日本歯周病学会会誌 66(秋季特別)   153   2024.10

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  • ジペプチジルペプチダーゼ阻害薬による歯周病抑制効果の検討

    湊 裕佳子, 野中 由香莉, 日高 興士, 阪本 泰光, 松岸 葵, 日吉 巧, ニン・ユールウィン, 安藤 大樹, 割田 悠子, 多部田 康一

    日本歯周病学会会誌 66(春季特別)   126   2024.4

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  • 歯周炎マウスモデルにおけるアリルイソチオシアネートの歯周組織破壊抑制効果の検討

    湊裕佳子, 野中由香莉, 日吉巧, 日吉巧, 松岸葵, LWIN Hnin Yu, 安藤大樹, 割田悠子, 多部田康一

    新潟歯学会雑誌   54 ( 1 )   2024

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  • フェルラ酸によるP.gingivalisバイオフィルム阻害作用の検討

    安藤大樹, LWIN Hnin Yu, 野中由香莉, 松岸葵, 湊裕佳子, 割田悠子, 高橋直紀, 多部田康一

    新潟歯学会雑誌   54 ( 2 )   2024

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  • 歯周炎患者におけるSRPおよびEr:YAGレーザー応用による歯石除去時の生体応答の検討

    保苅崇大, 両角俊哉, 両角俊哉, 野中由香莉, 濃野要, 小松康高, 杉原俊太郎, 山本裕子, 宮沢春菜, 鎗田将史, 新井恭子, 佐藤友則, 高橋直紀, 小牧基浩, 多部田康一

    日本歯周病学会会誌(Web)   66   2024

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  • 高齢者に対する歯肉剥離掻爬術の有効性についての後ろ向き研究

    保苅崇大, 野中由香莉, 松川由実, 佐藤圭祐, 原実生, 竹内麻衣, 高見澤圭, 山崎恭子, 都野隆博, 田村光, 日吉巧, 目黒史也, 干川絵美, 松岸葵, 金子千尋, 峯尾修平, 山下萌, 多部田康一

    日本歯周病学会会誌(Web)   65   2023

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  • 歯周病原細菌LPS由来炎症応答に対するアリルイソチオシアネートの抑制作用

    湊裕佳子, 野中由香莉, 日吉巧, 日吉巧, 松岸葵, YULWIN Hnin, 多部田康一

    日本歯周病学会会誌(Web)   65   2023

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  • Analysis of controlling periodontopathgenic biofilm by antimicrobial peptide N3L

    松岸葵, 野中由香莉, 野中由香莉, LWIN Hnin Yu, 多部田康一

    日本歯科保存学会学術大会プログラムおよび講演抄録集(Web)   157th   174   2022.11

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  • Ferulic acid inhibits the biofilm formation of Porphyromonas gingivalis

    Hnin Yu Lwin, 野中由香莉, 松岸 葵, 日吉 巧, 湊裕佳子, 多部田康一

    第65回秋季日本歯周病学会学術大会 プログラムおよび講演抄録集   120   2022.9

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  • 大豆由来ペプチドの抗バイオフィルム効果の検討

    Hnin Yu Lwin, 野中由香莉, 松岸葵, 多部田康一

    第65回春季日本歯周病学会学術大会 プログラムおよび講演抄録集   32   2022.6

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  • Analysis of antibacterial activity of ferulic acid against periodontopathogenic bacteria

    LWIN Hnin Yu, AOKI-NONAKA Yukari, AOKI-NONAKA Yukari, MATSUGISHI Aoi, HIYOSHI Takumi, HIYOSHI Takumi, MINATO Yukako, TABETA Koichi

    日本歯科保存学会学術大会プログラムおよび講演抄録集(Web)   156th   2022

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  • Antioxidant effect of food-derived peptide in human gingival epithelial cells

    Mineo S, Takahashi N, Tsuzuno T, Aoki-Nonaka Y, Tabeta K

    99th General Session of the IADR, Virtual meeting   2021.7

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  • Soybean peptide inhibits biofilm of periodontopathic bacteria via bactericidal activity.

    Hnin Yu Lwin, Aoki-Nonaka Y, Matsugishi A, Tabeta K

    99th General Session of the IADR. Virtual meeting   2021.7

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  • ヒト歯肉上皮細胞における米糠由来ペプチドによる抗酸化作用の検証

    峯尾修平, 高橋直紀, 都野隆博, 野中由香莉, 多部田康一

    第64回春季日本歯周病学会学術大会, web開催プログラムおよび講演抄録集   90   2021.5

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  • 大豆ペプチドはFusobacterium nucleatumのバイオフィルム形成を阻害する

    松岸葵, 野中由香莉, LWIN Hnin Yu, 多部田康一

    日本歯周病学会会誌(Web)プログラムおよび講演抄録集   63   105   2021.5

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  • Soybean peptide inhibits biofilm formation of Porphyromonas gingivalis and Fusobacterium nucleatum

    LWIN Hnin Yu, 野中由香莉, 松岸葵, 多部田康一

    日本歯科保存学会学術大会プログラムおよび講演抄録集(Web)   154th   149   2021

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  • 歯肉上皮細胞に発現するTRPV1活性化による抗炎症性作用の解析

    都野 隆博, 高橋 直紀, 峯尾 修平, 原 実生, 野中 由香莉, 多部田 康一

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集   152回   145 - 145   2020.6

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    Language：Japanese   Publisher：(NPO)日本歯科保存学会  

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  • 歯肉上皮細胞における抗酸化ストレス応答を活性化させる食物由来ペプチドの探索

    峯尾 修平, 高橋 直紀, 都野 隆博, 野中 由香莉, 田村 光, 多部田 康一

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集   152回   144 - 144   2020.6

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  • 広汎型重度慢性歯周炎患者に対して歯周組織再生療法を行った一症例

    野中 由香莉, 松岸 葵, 目黒 史也, 高橋 直紀, 多部田 康一

    日本歯周病学会会誌   62 ( 春季特別 )   155 - 155   2020.5

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  • コメペプチドとそのアミノ酸置換体はPorphyromonas gingivalis、Fusobacterium nucleatumのバイオフィルム形成を阻害する

    松岸 葵, 野中 由香莉, 竹内 麻衣, 原 実生, 早津 学, 三上 剛和, 牛木 辰男, 土門 久哲, 山崎 和久, 多部田 康一

    日本歯周病学会会誌   62 ( 春季特別 )   133 - 133   2020.5

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  • 広汎型重度慢性歯周炎患者に対して歯周組織再生療法を行った一症例

    野中 由香莉, 松岸 葵, 目黒 史也, 高橋 直紀, 多部田 康一

    日本歯周病学会会誌   62 ( 春季特別 )   155 - 155   2020.5

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  • コメペプチドとそのアミノ酸置換体はPorphyromonas gingivalis、Fusobacterium nucleatumのバイオフィルム形成を阻害する

    松岸 葵, 野中 由香莉, 竹内 麻衣, 原 実生, 早津 学, 三上 剛和, 牛木 辰男, 土門 久哲, 山崎 和久, 多部田 康一

    日本歯周病学会会誌   62 ( 春季特別 )   133 - 133   2020.5

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  • Rice peptide with amino acid substitution inhibits biofilm formation of periodontopathic bacteria.

    Matsugishi A, Aoki-Nonaka Y, Yokoji-Takeuchi M, Yamada-Hara M, Domon H, Yamazaki K, Tabeta K

    International Collaborative Symposium on Development of Human Resources in Practical Oral Health and Treatment.   2020

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  • Porphyromonas gingivalis aggravates experimental induced colitis in mice.

    Tsuzuno T, Takahashi T, Hara M, Takeuchi M, Aoki-Nonaka Y, Matsugishi A, Tabeta K, Yamazaki K

    International Collaborative Symposium on Development of Human Resources in Practical Oral Health and Treatment   2020

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  • コメペプチドとそのアミノ酸置換体はPorphyromonas gingivalis,Fusobacterium nucleatumのバイオフィルム形成を阻害する

    松岸葵, 松岸葵, 野中由香莉, 竹内麻衣, 原実生, 原実生, 早津学, 三上剛和, 牛木辰男, 土門久哲, 山崎和久, 多部田康一

    日本歯周病学会会誌(Web)   62   2020

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  • コメ由来ペプチドのアミノ酸置換体による歯周病原細菌のバイオフィルム阻害作用の解析

    松岸葵, 松岸葵, 野中由香莉, 竹内麻衣, 原実生, 原実生, 土門久哲, 寺尾豊, 山崎和久, 多部田康一

    新潟歯学会雑誌   50 ( 2 )   2020

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  • ヒト歯肉上皮細胞における抗酸化ストレス応答を増強する食物由来ペプチドの探索

    峯尾修平, 高橋直紀, 都野隆博, 都野隆博, 野中由香莉, 多部田康一

    新潟歯学会雑誌   50 ( 2 )   2020

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  • 広汎型重度慢性歯周炎患者に対して歯周組織再生療法を行った一症例

    野中由香莉, 松岸葵, 目黒史也, 高橋直紀, 多部田康一

    日本歯周病学会会誌(Web)   62   2020

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  • 嚥下された歯周病原細菌Porphyromonas gingivalisが炎症性腸疾患に及ぼす影響の解析

    都野 隆博, 高橋 直紀, 原 実生, 竹内 麻衣, Sulijaya Benso, 野中 由香莉, 松岸 葵, 多部田 康一, 山崎 和久

    新潟歯学会雑誌   49 ( 2 )   82 - 83   2019.12

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  • コメ由来ペプチドAmy I-1-18およびアミノ酸置換体はPorphyromonas gingivalisバイオフィルム形成を阻害する

    松岸 葵, 野中 由香莉, 竹内 麻衣, 原 実生, 土門 久哲, 山崎 和久, 多部田 康一

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集   151回   149 - 149   2019.10

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  • Porphyromonas gingivalis感染によって誘導される脂質代謝異常はTRPV1チャネルの活性化により制御される

    野中 由香莉, 原 実生, 竹内 麻衣, 松岸 葵, 山崎 和久, 多部田 康一

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集   151回   25 - 25   2019.10

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  • 歯周炎マウスモデルにおける生物活性代謝産物の抗菌機能(Antimicrobial Function of Bioactive Metabolite in Periodontitis Mice Model)

    Sulijaya Benso, Yamada-Hara Miki, Yokoji-Takeuchi Mai, Matsuda-Matsukawa Yumi, Yamazaki Kyoko, Matsugishi Aoi, Tsuzuno Takahiro, Sato Keisuke, Aoki-Nonaka Yukari, Takahashi Naoki, Tabeta Koichi, Yamazaki Kazuhisa

    日本歯周病学会会誌   61 ( 春季特別 )   119 - 119   2019.5

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  • Porphyromonas gingivalis感染により誘導される高LDL血症はTRPV1欠損マウスにおいて増悪する

    野中 由香莉, 原 実生, 竹内 麻衣, 松岸 葵, 山崎 和久, 多部田 康一

    日本歯周病学会会誌   61 ( 春季特別 )   138 - 138   2019.5

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  • コメ由来ペプチドAmy I-1-18、アミノ酸置換体がPorphyromonas gingivalisバイオフィルムに及ぼす影響

    松岸 葵, 野中 由香莉, 竹内 麻衣, 原 実生, 土門 久哲, 山崎 和久, 多部田 康一

    日本歯周病学会会誌   61 ( 春季特別 )   140 - 140   2019.5

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  • TRPV1 regulates inflammation and dyslipidemia induced by Porphyromonas gingivalis infection.

    Aoki-Nonaka Y, Yamada-Hara M, Ykoji M, Matsugishi A, Yamazaki K, Tabeta T

    97th General Session of the IADR   144   2019

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  • Rice Peptide and Amino Acid Substitutions Inhibit Porphyromonas Gingivalis Biofilm.

    Matsugishi A, Aoki-Nonaka Y, Yokoji M, Yamada-Hara M, Domon H, Yamazaki K, Tabeta K

    97th General Session of the IADR   219   2019

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  • Porphyromonas gingivalis感染により誘導される高LDL血症はTRPV1欠損マウスにおいて増悪する

    野中由香莉, 原実生, 竹内麻衣, 松岸葵, 松岸葵, 山崎和久, 多部田康一

    日本歯周病学会会誌(Web)   61   2019

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  • コメ由来ペプチドAmy I-1-18,アミノ酸置換体がPorphyromonas gingivalisバイオフィルムに及ぼす影響

    松岸葵, 松岸葵, 野中由香莉, 竹内麻衣, 原実生, 土門久哲, 山崎和久, 多部田康一

    日本歯周病学会会誌(Web)   61   2019

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  • Gタンパク質共役型受容体120はPorphyromonas gingivalis lipopolysaccharideによって活性化されるマクロファージにおいてKetoCの抗炎症作用を仲介する(G Protein-Coupled Receptor 120 mediates the anti-inflammatory effect of KetoC on macrophages induced with Porphyromonas gingivalis lipopolysaccharide)

    Sulijaya Benso, Takahashi Naoki, Yamada Miki, Yokoji Mai, Sato Keisuke, Aoki-Nonaka Yukari, Yamazaki Kazuhisa

    新潟歯学会雑誌   48 ( 2 )   112 - 112   2018.12

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  • ワサビ、シナモン由来成分による歯周病原細菌に対する抗菌作用および抗炎症作用の検討

    野中 由香莉, 多部田 康一, 横地 麻衣, 松岸 葵, 山崎 和久

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集   148回   151 - 151   2018.5

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  • 生理活性代謝産物はPorphyromonas gingivalisリポポリサッカライドで処理したマクロファージからの炎症誘導性サイトカイン産生をGタンパク質共役受容体120を介して抑制する(Bioactive metabolite inhibits proinflammatory cytokines by macrophage treated with Porphyromonas gingivalis lipopolysaccharide via G-Protein-coupled Receptor 120)

    Sulijaya Benso, Takahashi Naoki, Yamada Miki, Yokoji Mai, Sato Keisuke, Aoki-Nonaka Yukari, Nakajima Takako, Yamazaki Kazuhisa

    日本歯周病学会会誌   60 ( 春季特別 )   119 - 119   2018.5

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  • 米由来抗菌ペプチドの歯周炎モデルマウスにおける抗炎症作用の検討

    野中 由香莉, 多部田 康一, 横地 麻衣, 松田 由実, 山崎 和久, 吉江 弘正

    日本歯周病学会会誌   59 ( 春季特別 )   134 - 134   2017.4

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  • TRPV1 and TRPA1 Ion Channels in CD4+T Cells: Novel Therapeutic Targets in IBD?

    Samuel Bertin, Yukari Aoki-Nonaka, Brigid Boland, John Chang, Samuel Ho, Armen Akopian, Alessandra Franco, Eyal Raz

    INFLAMMATORY BOWEL DISEASES   23   S78 - S79   2017.2

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  • 米由来抗菌ペプチドの歯周炎モデルマウスにおける抗炎症作用の検討

    野中由香莉, 多部田康一, 横地麻衣, 横地麻衣, 松田由実, 松田由実, 山崎和久, 吉江弘正

    日本歯周病学会会誌(Web)   59   2017

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  • 細菌抗原によるPCSK9産生の誘導機構

    横地麻衣, 横地麻衣, 多部田康一, 宮澤春菜, 野中由香莉, 高橋直紀, 松田由実, 松田由実, 佐藤圭祐, 佐藤圭祐, 山田実生, 山田実生, 伊藤晴江, 中島貴子, 山崎和久

    日本歯科保存学会学術大会プログラムおよび講演抄録集(Web)   145回   145 - 145   2016.10

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    J-GLOBAL

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  • コメ由来抗菌ペプチドの抗炎症作用と創傷治癒作用の解析

    野中 由香莉, 横地 麻衣, 多部田 康一, 山崎 和久

    日本歯周病学会会誌   58 ( 秋季特別 )   121 - 121   2016.9

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  • コメ由来抗菌ペプチドの抗炎症作用と創傷治癒作用の解析

    野中由香莉, 野中由香莉, 横地麻衣, 横地麻衣, 多部田康一, 山崎和久

    日本歯周病学会会誌(Web)   58   2016

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  • 歯周炎患者におけるPISAと血中マーカーとの関連性

    本田 朋之, 宮沢 春菜, 野中 由香莉, 高橋 直紀, 多部田 康一, 中島 貴子, 山崎 和久

    日本歯周病学会会誌   57 ( 秋季特別 )   127 - 127   2015.8

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  • 歯周炎患者におけるPISAと血中マーカーとの関連性

    本田朋之, 本田朋之, 宮沢春菜, 宮沢春菜, 野中由香莉, 野中由香莉, 高橋直紀, 高橋直紀, 多部田康一, 中島貴子, 山崎和久

    日本歯周病学会会誌(Web)   57   2015

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  • Porphyromonas gingivalis口腔感染による全身応答 血清中サイトカインプロファイルの変化

    宮内 小百合, 前川 知樹, 青木 由香莉, 宮沢 春菜, 多部田 康一, 中島 貴子, 山崎 和久

    新潟歯学会雑誌   42 ( 1 )   63 - 63   2012.6

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  • Porphyromonas gingivalis口腔感染による脂質代謝関連遺伝子の変動

    宮内 小百合, 前川 知樹, 高橋 直紀, 多部田 康一, 青木 由香莉, 宮下 博考, 宮沢 春菜, 中島 貴子, 山崎 和久

    日本歯周病学会会誌   53 ( 秋季特別 )   110 - 110   2011.9

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  • Porphyromonas gingivalis感染マウスモデルにおける炎症応答へのNKT細胞の関与

    青木 由香莉, 中島 貴子, 宮下 博考, 宮内 小百合, 宮沢 春菜, 高橋 直紀, 前川 知樹, 多部田 康一, 山崎 和久

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集   135回   81 - 81   2011.9

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  • 歯周炎罹患がPCSK9および脂質プロファイルに及ぼす影響

    宮沢 春菜, 本田 朋之, 宮内 小百合, 青木 由香莉, 宮下 博考, 高橋 直紀, 前川 知樹, 奥井 隆文, 土門 久哲, 伊藤 晴江, 中島 貴子, 多部田 康一, 山崎 和久

    日本歯周病学会会誌   53 ( 秋季特別 )   105 - 105   2011.9

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  • THE EFFECTS OF NKT CELLS ON ATHEROGENESIS IN PORPHYROMONAS GINGIVALIS INFECTION MODEL

    T. Nakajima, Y. Aoki, H. Miyashita, S. Miyauchi, H. Miyazawa, K. Tabeta, K. Yamazaki

    INFLAMMATION RESEARCH   60   220 - 220   2011.6

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  • 歯周炎病変部におけるIL-17+FOXP3+T細胞の関与

    奥井 隆文, 青木 由香莉, 伊藤 晴江, 本田 朋之, 山崎 和久

    日本歯周病学会会誌   53 ( 春季特別 )   114 - 114   2011.4

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  • Porphyromonas gingivalis長期感染マウスモデルにおける炎症、脂質代謝関連遺伝子の発現変動

    多部田 康一, 前川 知樹, 高橋 直紀, 青木 由香莉, 宮下 博考, 宮内 小百合, 奥井 隆文, 中島 貴子, 山崎 和久

    日本歯周病学会会誌   52 ( 秋季特別 )   82 - 82   2010.9

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  • 新たな視点から口腔疾患を誘因とする難治性疾患を考える 歯周疾患の動脈硬化症リスクに及ぼす影響

    山崎 和久, 多部田 康一, 前川 知樹, 高橋 直紀, 青木 由香莉, 宮下 博考, 宮内 小百合, 米澤 大輔, 本田 朋之, 奥井 隆文, 奥井 桂子, 伊藤 晴江, 中島 貴子

    Journal of Oral Biosciences   52 ( Suppl )   67 - 67   2010.9

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  • Porphyromonas gingivalis由来FimA線毛のサイトカイン産生誘導能におけるLipoproteinの関与

    青木 由香莉, 多部田 康一, 山崎 和久

    新潟歯学会雑誌   40 ( 1 )   98 - 98   2010.6

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  • 動脈硬化自然発症モデルマウスにおけるPorphyromonas gingivalis長期感染後の血清脂質プロファイルの変化

    多部田 康一, 前川 知樹, 高橋 直紀, 青木 由香莉, 宮下 博考, 宮内 小百合, 奥井 隆文, 中島 貴子, 山崎 和久

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集   132回   44 - 44   2010.5

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  • Porphyromonas gingivalis由来FimA線毛のサイトカイン産生誘導能におけるLipoproteinの関与

    青木 由香莉

    日本歯周病学会会誌   52 ( 春季特別 )   101 - 101   2010.4

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  • Porphyromonas gingivalis感染が冠動脈疾患リスクに及ぼす影響 基本健康診査受診者における解析

    米澤 大輔, 宮下 博孝, 前川 知樹, 高橋 直紀, 青木 由香莉, 奥井 隆文, 中島 貴子, 田辺 直仁, 多部田 康一, 山崎 和久

    新潟歯学会雑誌   39 ( 1 )   87 - 87   2009.6

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  • Porphyromonas gingivalis感染が冠動脈疾患リスクに及ぼす影響 歯周炎モデルマウスの病態解析

    高橋 直紀, 前川 知樹, 青木 由香莉, 宮下 博考, 奥井 隆文, 中島 貴子, 多部田 康一, 山崎 和久

    日本歯周病学会会誌   51 ( 春季特別 )   104 - 104   2009.4

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  • Porphyromonas gingivalis感染が冠動脈疾患リスクに及ぼす影響 感染によるマウス組織・臓器への影響

    前川 知樹, 高橋 直紀, 青木 由香莉, 宮下 博考, 奥井 隆文, 中島 貴子, 多部田 康一, 山崎 和久

    日本歯周病学会会誌   51 ( 春季特別 )   105 - 105   2009.4

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  • Porphyromonas gingivalis感染が冠動脈疾患リスクに及ぼす影響 基本健康診査受診者における解析

    米澤 大輔, 宮下 博考, 前川 知樹, 高橋 直紀, 青木 由香莉, 奥井 隆文, 中島 貴子, 田辺 直仁, 多部田 康一, 山崎 和久

    日本歯周病学会会誌   51 ( 春季特別 )   127 - 127   2009.4

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  • 歯周炎組織におけるTh17関連サイトカイン/マーカーの遺伝子発現解析

    本田 朋之, 青木 由香莉, 高橋 直紀, 前川 知樹, 中島 貴子, 伊藤 晴江, 多部田 康一, 奥井 隆文, 梶田 桂子, 土門 久哲, 吉江 弘正, 山崎 和久

    日本歯周病学会会誌   50 ( 秋季特別 )   88 - 88   2008.9

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  • 歯周炎組織における炎症性および恒常性維持ケモカインの発現バランス

    中島 貴子, 天沼 亮子, 青木 由香莉, 本田 朋之, 奥井 隆文, 土門 久哲, 梶田 桂子, 高橋 直紀, 前川 知樹, 伊藤 晴江, 多部田 康一, 山崎 和久

    日本歯科保存学雑誌   51 ( 春季特別 )   102 - 102   2008.5

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  • 骨端軟骨のFGFR3発現局在における分子組織化学的検索

    青木 由香莉, 李 敏啓, Sobhan Ubaidus, 小澤 英浩, 前田 健康, 吉江 弘正, 山崎 和久, 網塚 憲生

    新潟歯学会雑誌   36 ( 2 )   317 - 318   2006.12

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  • 骨端軟骨における線維芽細胞増殖因子受容体III型(FGFR3)の発現について

    青木 由香莉, 李 敏啓, 網塚 憲生

    日本骨形態計測学会雑誌   16 ( 2 )   S73 - S73   2006.7

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Industrial property rights

  • 抗菌性ジペプチド化合物

    日高興士, 野中由香莉, 多部田康一關谷瑞樹, 阪本泰光

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    Applicant：国立大学法人 神戸大学，国立大学法人 新潟大学，学校法人 岩手医科大学

    Application no：特願2022-110510  Date applied：2022.7

    Patent/Registration no：特許7836044  Date registered：2026.3 

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Awards

  • 優秀論文賞

    2024.5   日本歯科保存学会  

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  • IADR/Unilever Hatton Divisional Award

    2012.6   90th International Association for Dental Research  

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  • デンツプライ賞

    2011.10   日本歯科保存学会  

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  • BD Japan Young Investigator’s Travel Award.

    2010.8   14th International Congress of Immunology  

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Research Projects

  • Analysis of the new occlusal trauma diagnosis biomaker by the microRNA of GCF

    Grant number：25K13031

    2025.4 - 2028.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

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  • 糖非発酵グラム陰性細菌のペプチド代謝機構を標的とした抗菌薬開発

    Grant number：24K09765

    2024.4 - 2027.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    阪本 泰光,日高 興士,野中 由香莉

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • 選択的ジペプチジルペプチダーゼ阻害剤による糖尿病関連歯周炎に対する創薬研究

    Grant number：24K12945

    2024.4 - 2027.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    野中 由香莉, 田中 信忠,阪本 泰光, 日高 興士, 多部田 康一

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    Authorship：Principal investigator 

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • MPN武装細菌による口腔マイクロバイオームの再構築

    Grant number：23K18357

    2023.6 - 2025.3

    System name：科学研究費助成事業

    Research category：挑戦的研究(萌芽)

    Awarding organization：日本学術振興会

    多部田 康一, 江島 広貴, 野中 由香莉, 高橋 直紀, 中島 麻由佳

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    Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）

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  • Development of new modalities in periodontal treatment using cell binding backpack

    Grant number：23K27769

    2023.4 - 2026.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\18850000 （ Direct Cost: \14500000 、 Indirect Cost：\4350000 ）

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    Grant number：21K09913

    2021.4 - 2024.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Therapeutic biofilm as a new approach to the treatment of periodontal disease and root caries

    Grant number：19K22705

    2019.6 - 2021.3

    System name：Grants-in-Aid for Scientific Research Challenging Research (Exploratory)

    Research category：Challenging Research (Exploratory)

    Awarding organization：Japan Society for the Promotion of Science

    Tabeta Koichi

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    Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）

    This study is a challenge to control the onset and progression of periodontal disease and root caries by "artificial formation of therapeutic biofilm". We explored the possibility of creating the concept of a therapeutic biofilm by assimilating nanomedicines into the initial biofilm to create a symbiosis environment (less harmful bacterial flora).
    The conditions for the production of S. mitis biofilm containing liponanocapsules were clarified, indicating the possibility of creating a therapeutic biofilm. The degradation rate of the capsules was measured, suggesting the environmentally responsive degradation of the capsules, induced by the growth of the bacteria and the maturation of the biofilm.

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  • Peptide drugs derived from food material for periodontal disease preventing flail and AMR

    Grant number：19H03829

    2019.4 - 2023.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\17160000 （ Direct Cost: \13200000 、 Indirect Cost：\3960000 ）

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  • 緑茶およびワサビ由来成分の抗菌・抗炎症作用による歯周病予防・治療効果の検討

    2019.4 - 2020.3

    System name：食と健康研究助成金

    Awarding organization：本庄国際奨学財団

    野中 由香莉

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    Authorship：Principal investigator  Grant type：Competitive

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  • Study of cinnamon components about the inhibitory effect on periodontal disease

    Grant number：18K17043

    2018.4 - 2021.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

    Research category：Grant-in-Aid for Early-Career Scientists

    Awarding organization：Japan Society for the Promotion of Science

    Nonaka Yukari

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    The aim of this study was to elucidate the antibacterial and anti-inflammatory activities of a component of cinnamon, and to contribute to the development of a new therapeutic agent for periodontal disease.
    The antibacterial activity against typical periodontopathic bacteria was clarified. In addition, a component of cinnamon showed anti-inflammatory activity against the production of inflammatory cytokines induced by LPS stimulation from periodontopathic bacteria. Furthermore, the inhibitory effect on alveolar bone resorption was demonstrated using a mouse model of periodontal disease.
    These results suggest the possibility of applying a component of cinnamon as a novel periodontal drug.

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  • コメ由来抗菌ペプチドの生体防御機能の解明―新規歯周病医薬開発を目指して―

    Grant number：17J40165

    2017.4 - 2020.3

    System name：科学研究費助成事業 特別研究員奨励費

    Research category：特別研究員奨励費

    Awarding organization：日本学術振興会

    野中 由香莉

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    Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）

    歯周病は歯周病原細菌感染によって引き起こされる炎症性の疾患であり、バイオフィルム感染症と位置付けられる。バイオフィルムは、一般に薬剤の浸透に抵抗性を持つ。一方で、抗菌薬の使用制限が国策として決まり、既存の抗菌薬によるバイオフィルム形成阻止が実用化困難となりつつある中で、新たな治療薬の開発が急務である。以上の背景から、食品由来の安全性と抗菌活性を有する上記のコメ由来ペプチドの応用が可能ではないかと考えた。
    コメを原材料としたペプチド素材の歯周病に対する効果について検討を行い、本年度は特にその抗菌作用に着目した。これまでの結果において、代表的な歯周病原細菌であるP. gingivalis に対する抗菌活性が確認できたAmy1-1-18ペプチドと、さらにそのアミノ酸置換体を用いて歯周病原細菌バイオフィルムに対する効果の検証を行った。本研究においては、P. gingivalisおよびF. nucleatumを対象としてバイオフィルムモデルを構築し、ペプチドの抗菌活性について評価を行った。
    結果として、Amy1-1-18ペプチドおよびそのアミノ酸置換体のいくつかは、P. gingivalisおよびF. nucleatumのバイオフィルム形成を阻害することが示された。中でも、Amy1-1-18ペプチドの12番目の塩基配列を置換したペプチドにおいては、F. nucleatumに対して極めて強い抗菌活性を示すことが明らかとなった。さらに、そのメカニズムとして強い膜障害性を有することが示された。以上より、アミノ酸置換によるカチオン性の強化により膜を標的とした抗菌作用が強化されたことが示唆された。また、抗菌活性の選択性がアミノ酸置換で調整できる可能性が示唆された。すなわち、より狭スペクトルで耐性菌が生じにくい新たなバイオフィルム制御医薬としての発展の可能性が示唆された。

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  • Analysis of anti-inflammatory effect of vitaminD against periodonthopathic bacteria

    Grant number：15K20619

    2015.3 - 2018.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Research category：Grant-in-Aid for Young Scientists (B)

    Awarding organization：Japan Society for the Promotion of Science

    NONAKA Yukari

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    Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）

    Vitamin D is a nutrient involved in maintenance of bone homeostasis. The purpose of this study is to clarify the anti-inflammatory effect of vitamin D against periodontal pathogenic bacterial infection. Active vitamin D, 1,25(OH)2D3 couldn’t suppress the inflammatory response induced by periodontal pathogenic bacterial LPS in macrophages. Furthermore, wound healing assay was performed using Epi4 cells derived from human gingival epithelial cells, but wound healing promoting effect was not observed by addition of active vitamin D.

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  • The Periodontal-Metabolic syndrome etiology via the intestine -the role of TRP channels-

    Grant number：25893079

    2013.8 - 2015.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up

    Research category：Grant-in-Aid for Research Activity start-up

    Awarding organization：Japan Society for the Promotion of Science

    NONAKA Yukari

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    Grant amount：\2730000 （ Direct Cost: \2100000 、 Indirect Cost：\630000 ）

    Periodontitis as periodontal bacterial infection has been implicated as a risk factor for diabetes, atherosclerotic vascular diseases, and non-alcoholic fatty liver disease. TRP channels are Ca2+ permeable cation channels, which play an important role in the pathogenesis and progression of inflammatory responses and metabolic disorders. The present study has demonstrated that TRPV1 can regulate inflammatory responses and lipid metabolism in the liver. This result suggests that TRP channel may affect the pathological mechanism of systemic diseases caused by periodontitis.

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  • TRPチャネルの免疫調節機能―腸管を介した歯周病原細菌による炎症誘導メカニズムへの関与

    2013.4 - 2014.3

    System name：新潟大学プロジェクト推進経費

    Awarding organization：新潟大学

    野中 由香莉

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    Authorship：Principal investigator  Grant type：Competitive

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Teaching Experience

  • 歯科衛生学I

    2026
    Institution name：新潟大学

  • 高齢者福祉論II

    2026
    Institution name：新潟大学

  • 社会調査法

    2026
    Institution name：新潟大学

  • 医療統計学

    2026
    Institution name：新潟大学

  • リサーチ・メソッズ・アドバンスト

    2026
    Institution name：新潟大学

  • 社会福祉原論II

    2026
    Institution name：新潟大学

  • 歯科衛生学II

    2026
    Institution name：新潟大学

  • 早期臨床実習IIB

    2026
    Institution name：新潟大学

  • 衛生学・公衆衛生学

    2026
    Institution name：新潟大学

  • PBL入門

    2026
    Institution name：新潟大学

  • 栄養学

    2026
    Institution name：新潟大学

  • 障害者福祉論II

    2026
    Institution name：新潟大学

  • 臨床歯学演習

    2026
    Institution name：新潟大学

  • 児童福祉論II

    2026
    Institution name：新潟大学

  • 臨床歯科学II

    2025
    Institution name：新潟大学

  • 歯科臨床概論

    2024
    Institution name：新潟大学

  • 臨床実習I

    2022
    Institution name：新潟大学

  • 臨床実習II

    2022
    Institution name：新潟大学

  • 歯周再生治療学演習IA

    2022
    Institution name：新潟大学

  • 歯周再生治療学演習IIA

    2022
    Institution name：新潟大学

  • 臨床歯学ｺｰｽﾜｰｸ(歯周歯科関係コースワークI)

    2022
    Institution name：新潟大学

  • 歯周再生治療学演習IIB

    2022
    Institution name：新潟大学

  • 歯周再生治療学演習IB

    2022
    Institution name：新潟大学

  • 臨床歯学ｺｰｽﾜｰｸ(歯周歯科関係コースワークII)

    2022
    Institution name：新潟大学

  • 生体防御機能回復学IA

    2022
    Institution name：新潟大学

  • 生体防御機能回復学IIA

    2022
    Institution name：新潟大学

  • 歯周治療学IB

    2022
    Institution name：新潟大学

  • 歯周治療学IA

    2022
    Institution name：新潟大学

  • 生体防御機能回復学IB

    2022
    Institution name：新潟大学

  • 歯周治療学IIB

    2022
    Institution name：新潟大学

  • 生体防御機能回復学IIB

    2022
    Institution name：新潟大学

  • 歯周治療学IIA

    2022
    Institution name：新潟大学

  • 歯科衛生士臨床実習II

    2021
    Institution name：新潟大学

  • 歯周治療学演習IIB

    2021
    Institution name：新潟大学

  • 歯周治療学演習IA

    2021
    Institution name：新潟大学

  • 歯周治療学演習IIA

    2021
    Institution name：新潟大学

  • 歯周治療学演習IB

    2021
    Institution name：新潟大学

  • 歯周病学

    2020
    Institution name：新潟大学

  • 歯科衛生学実習Ⅱ

    2019
    -
    2024
    Institution name：新潟大学

  • 生涯にわたる歯と咬合

    2019
    -
    2023
    Institution name：新潟大学

  • 臨床実習Ⅱ

    2019
    Institution name：新潟大学

  • 臨床実習Ⅲ

    2019
    Institution name：新潟大学

  • 臨床予備実習

    2019
    Institution name：新潟大学

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