Updated on 2024/05/19

写真a

 
BAMBA KEIKO
 
Organization
University Medical and Dental Hospital Anesthesiology Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
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Research Interests

  • Anesthesiology

  • Flavoprotein fluorescense imaging

  • neuropathic pain

Research Areas

  • Life Science / Anesthesiology

Research History (researchmap)

  • Niigata University   Medical and Dental Hospital, Anesthesiology   Assistant Professor

    2021.7

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  • 新潟大学医歯学総合病院   麻酔科   特任助教

    2020.3 - 2021.6

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  • 新潟大学医歯学総合研究科   麻酔科学分野   医員(社会人大学院生)

    2016.4 - 2020.8

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  • 新潟大学医歯学総合病院   麻酔科   医員

    2013.4 - 2020.2

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  • 新潟市民病院   麻酔科

    2010.6 - 2013.3

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  • 新潟大学医歯学総合病院   麻酔科   医員

    2009.4 - 2010.5

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  • 新潟市民病院   臨床研修医

    2007.4 - 2009.3

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Research History

  • Niigata University   Anesthesiology, University Medical and Dental Hospital   Assistant Professor

    2021.7

  • Niigata University   University Medical and Dental Hospital Anesthesiology   Specially Appointed Assistant Professor

    2020.3 - 2021.6

Education

  • Niigata University   Graduate School of Medical and Dental Sciences   Division of Anesthesiology

    2016.4 - 2020.9

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    Notes: 博士課程卒業

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  • Niigata University   Faculty of Medicine   School of Medicine

    1999.4 - 2005.3

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Professional Memberships

Qualification acquired

  • Doctor

 

Papers

  • Serotonin Plays a Key Role in the Development of Opioid-Induced Hyperalgesia in Mice International journal

    Mika Sasaki, Yoshinori Kamiya, Keiko Bamba, Takeshi Onishi, Keiichiro Matsuda, Tatsuro Kohno, Miyuki Kurabe, Kenta Furutani, Harue Yanagimura

    The Journal of Pain   22 ( 6 )   715 - 729   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Opioid usage for pain therapy is limited by its undesirable clinical effects, including paradoxical hyperalgesia, also known as opioid-induced hyperalgesia (OIH). However, the mechanisms associated with the development and maintenance of OIH remain unclear. Here, we investigated the effect of serotonin inhibition by the 5-HT3 receptor antagonist, ondansetron (OND), as well as serotonin deprivation via its synthesis inhibitor para-chlorophenylalanine, on mouse OIH models, with particular focus on astrocyte activation. Co-administering of OND and morphine, in combination with serotonin depletion, inhibited mechanical hyperalgesia and astrocyte activation in the spinal dorsal horn of mouse OIH models. Although previous studies have suggested that activation of astrocytes in the spinal dorsal horn is essential for the development and maintenance of OIH, herein, treatment with carbenoxolone (CBX), a gap junction inhibitor that suppresses astrocyte activation, did not ameliorate mechanical hyperalgesia in mouse OIH models. These results indicate that serotonin in the spinal dorsal horn, and activation of the 5-HT3 receptor play essential roles in OIH induced by chronic morphine, while astrocyte activation in the spinal dorsal horn serves as a secondary effect of OIH. Our findings further suggest that serotonergic regulation in the spinal dorsal horn may be a therapeutic target of OIH. PERSPECTIVE: The current study revealed that the descending serotonergic pain-facilitatory system in the spinal dorsal horn is crucial in OIH, and that activation of astrocytes is a secondary phenotype of OIH. Our study offers new therapeutic targets for OIH and may help reduce inappropriate opioid use.

    DOI: 10.1016/j.jpain.2020.12.008

    PubMed

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  • Preoperative Implementation of Transverse Thoracic Muscle Plane Block and Rectus Sheath Block Combination for Pediatric Cardiac Surgery International journal

    Tomohiro Yamamoto, Yutaka Seino, Keiichiro Matsuda, Hidekazu Imai, Keiko Bamba, Ai Sugimoto, Shuichi Shiraishi, Ehrenfried Schindler

    Journal of Cardiothoracic and Vascular Anesthesia   34 ( 12 )   3367 - 3372   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Systemic intravenous administration of opioids is the main treatment strategy for intraoperative and postoperative pain management in patients undergoing cardiac surgery with sternotomy. However, using lower doses of opioids may achieve the well-established benefits of the fast-track approach, with minimal opioid-related side effects. Postoperative pain is coupled with a long stay in the intensive care unit. Although neuraxial anesthesia has some benefits, its use remains controversial due to the potential development of epidural hematoma after anticoagulation for cardiopulmonary bypass and coagulopathy after cardiac surgery. Therefore, there is a need for other effective postoperative analgesic strategies, such as peripheral nerve blocks other than neuraxial anesthesia, for cardiac surgery with sternotomy. The effects of real-time ultrasound-guided transverse thoracic muscle plane (TTP) block on postoperative pain after sternotomy have been reported; however, the pain and discomfort in the epigastric area caused by chest drainage tubes placed through the rectus abdominis muscle also are major postoperative problems after cardiac surgery. Herein, the authors report on a preoperative combination of TTP block and rectus sheath block (RSB) for postoperative pain management after cardiac surgery with sternotomy that addresses pain in both the chest and epigastric areas. Considering previous studies, it is presumed that preemptive analgesic effects can be expected via a combination of the TTP block and RSB, and indeed, the preemptive effect was observed in the present study's patients. In this article, the procedure and tips for combining the TTP block and RSB are introduced.

    DOI: 10.1053/j.jvca.2020.07.041

    PubMed

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  • A novel parameter for pulmonary blood flow during palliative procedures: velocity time integral of the pulmonary vein† International journal

    Shuichi Shiraishi, Keiko Bamba, Ai Sugimoto, Masashi Takahashi, Masanori Tsuchida

    European Journal of Cardio-Thoracic Surgery   55 ( 5 )   823 - 828   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    OBJECTIVES: The main goal of palliative procedures for congenital heart defects is adequate pulmonary blood flow (PBF), but precise intraoperative PBF evaluation is sometimes difficult. The purpose of this preliminary study was to investigate the usefulness of velocity time integral of the pulmonary vein (PV-VTI) measured by transoesophageal echocardiography (TOE) at the time of palliative procedure as a parameter for PBF. METHODS: Case histories of 63 patients who underwent palliative procedures (bilateral pulmonary artery banding in 18 patients, main pulmonary artery banding in 22 patients and systemic-to-pulmonary artery shunt in 23 patients) and whose intraoperative PV-VTI was measured by TOE from 2011 to 2017 at our centre were retrospectively reviewed. Low-body-weight infants, cases in which cardiopulmonary bypass was used and cases that were anatomically difficult to measure were excluded. RESULTS: PV-VTIs measured at 4 orifices of the pulmonary veins were all significantly decreased in both the bilateral pulmonary artery banding and main pulmonary artery banding groups and increased in the systemic-to-pulmonary artery shunt group immediately after the procedure. There were significant correlations between the velocity time integrals of both right and left pulmonary veins and arterial oxygen saturation (r = 0.564 and 0.703). Nine patients (6 bilateral pulmonary artery banding and 3 systemic-to-pulmonary artery shunt) required unplanned early reoperation due to inadequate PBF; their PV-VTIs were significantly different from those of patients not requiring reoperation. No major complications related to TOE occurred postoperatively. CONCLUSIONS: The PV-VTI measured by TOE during palliative procedures reflected the change of PBF and could help identify patients at higher risk of early reoperation due to inadequate PBF. This parameter may be a useful additional tool for evaluating intraoperative PBF.

    DOI: 10.1093/ejcts/ezy465

    PubMed

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  • 肺動脈絞扼手術時の術中経食道心エコーによる肺静脈verocity time integral(VTI)測定の意義

    白石 修一, 杉本 愛, 文 智勇, 高橋 昌, 土田 正則, 今井 英一, 吉田 敬之, 大橋 宣子, 番場 景子

    日本小児循環器学会雑誌   32 ( Suppl.1 )   s1 - 373   2016.7

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    Language:Japanese   Publisher:(NPO)日本小児循環器学会  

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  • Anesthetic management of a patient with a giant ovarian tumor containing 83 l of fluid

    Keiko Bamba, Tatsunori Watanabe, Tatsuro Kohno

    SpringerPlus   2 ( 1 )   487 - 487   2013

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1186/2193-1801-2-487

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Presentations

  • 神経障害性疼痛モデルマウスの大脳皮質一次体性感覚野及び脊髄後角における神経活動の経時的変化の解析

    番場景子

    日本麻酔科学会第66回学術集会  2019.5 

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    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Analysis Of Neural Activity In The Neuropathic Pain Mouse Model Using Flavoprotein Fluorescence Imaging

    KEIKO BAMBA

    ASA anual meeting  2018.10 

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    Language:English   Presentation type:Poster presentation  

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  • 右室依存性冠循環が疑われる純型肺動脈閉鎖症の麻酔管理経験」

    番場景子

    第22回日本心臓血管麻酔学会  2018.9 

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    Language:Japanese   Presentation type:Poster presentation  

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  • Intraoperative Doppler echocardiography of pulmonary venous flow is useful in predicting reoperation in pulmonary artery banding

    KEIKO BAMBA

    ESA annual meeting  2018.6 

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    Language:English   Presentation type:Poster presentation  

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  • フラビン蛋白蛍光イメージング法を用いたSpared nerve injury(SNI)モデルマウスの解析

    番場景子

    日本麻酔科学会第65回学術集会  2018.5 

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    Language:Japanese   Presentation type:Poster presentation  

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  • 基底膜障害による気道粘膜の血管透過性亢進を原因とする抜管困難を呈した13q-症候群の乳児の麻酔経験

    番場景子

    第23回日本小児麻酔学会  2017.10 

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    Language:Japanese   Presentation type:Poster presentation  

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  • 肺動脈絞扼術における術中経食道心エコー所見と再手術との関連性の検討

    番場景子

    第21回日本心臓血管麻酔学会学術大会  2015.9 

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    Language:Japanese   Presentation type:Poster presentation  

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Research Projects

  • 神経障害性痛における脊髄―大脳皮質神経活動連関とグリア細胞活性化制御の影響

    Grant number:20K17807

    2020.4 - 2023.3

    System name:科学研究費助成事業 若手研究

    Research category:若手研究

    Awarding organization:日本学術振興会

    番場 景子

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    Authorship:Principal investigator 

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    神経障害性疼痛においてもS1のシナプスの興奮性や可塑性が高まることが知られている。また、脊髄後角においても同様に神経興奮性とシナプス可塑性は、神経障害性疼痛状態で増強されると従来考えられており、in vitro脊髄スライスを用いたパッチクランプの研究では、興奮性シナプス電流と細胞興奮性の両方が神経障害性疼痛モデルで増強し、in vivoパッチクランプ研究においても末梢神経損傷により、神経損傷側の後肢への無害な刺激による細胞興奮性と興奮性シナプス増強が誘導されることが報告されている。当研究室固有のフラビン蛋白蛍光イメージング法(AFI)ではミトコンドリアの電子伝達系の一員である内因性蛋白の性質を利用し、in vivoでの神経活動を低侵襲かつ容易に可視化することができる。本研究では、神経障害性疼痛の発症とS1や脊髄後角の神経可塑性変化におけるTNF-α、IL-βなどの炎症性サイトカインやグリア細胞の関連性について、AFIを用いたin vivoでの大脳皮質一次体性感覚野及び脊髄後角の神経活動を評価し、明らかにすることを目的としている。
    昨年度はSNIモデルマウスを作成し、大脳皮質一次体性感覚野及び、脊髄後角においてフラビン蛋白蛍光イメージングを用いて神経活動を測定した結果、大脳皮質一次体性感覚野では経時的に神経活動が増強したが、脊髄では神経活動の減弱を認める結果となった。当該年度は脊髄における抑制性ニューロンの喪失により興奮性ニューロンが優位となり下行性抑制系の抑制(脱抑制)及び相対的に上行性伝達経路の活動が亢進し、痛み刺激として大脳の神経活動を亢進させ、神経障害性疼痛を発症するのではないかと仮説を立て、脊髄と大脳皮質一次体性感覚野における抑制性ニューロン(Pax2)と神経細胞(NeuN)の経時的変化を免疫組織学的に検討している。

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  • Elucidation of the involvement of microglia in neuropathic pain using flavoprotein autofluorescence imaging

    Grant number:18K16474

    2018.4 - 2020.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

    Research category:Grant-in-Aid for Early-Career Scientists

    Awarding organization:Japan Society for the Promotion of Science

    BAMBA KEIKO

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    First, SNI model mice were created, and it was confirmed by the von Frey test that the mechanical withdrawal threshold decreased from the 4th day to the 21st day after the operation.FAI measurements of neural activity in the primary somatosensory cortex (S1) and spinal dorsal horn of the same mouse model showed that S1 showed enhancement over time, whereas spinal cord showed no enhancement but rather a decreasing trend. Next, the effect of inhibition of microglial activity by administration of minocycline on neuropathic pain was examined. Administration of minocycline to the same model mice was able to prevent a decrease in the mechanical withdrawal threshold. On the other hand, the neural activity measurement by FAI did not show the recovery of spinal cord response of SNI model mice by administration of minocycline.

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