Updated on 2024/04/25

写真a

 
GOTO Tatsuya
 
Organization
University Medical and Dental Hospital Thoracic Surgery Assistant Professor
Title
Assistant Professor
External link

Degree

  • Doctor of Medical Science ( 2001   Niigata University )

Research History

  • Niigata University   University Medical and Dental Hospital Thoracic Surgery   Assistant Professor

    2020.4

 

Papers

  • Surgical Treatment Outcomes of Patients with Non-Small Cell Lung Cancer and Lymph Node Metastases. International journal

    Yuki Shimizu, Terumoto Koike, Toshiki Hasebe, Masaya Nakamura, Tatsuya Goto, Shin-Ichi Toyabe, Masanori Tsuchida

    Cancers   15 ( 12 )   2023.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    This study aimed to investigate the appropriate subgroups for surgery and adjuvant chemotherapy in patients with non-small-cell lung cancer (NSCLC) and nodal metastases. We retrospectively reviewed 210 patients with NSCLC and nodal metastases who underwent surgery and examined the risk factors for poor overall survival (OS) and recurrence-free probability (RFP) using multivariate Cox proportional hazards analysis. Pathological N1 and N2 were observed in 114 (52.4%) and 96 (47.6%) patients, respectively. A single positive node was identified in 102 patients (48.6%), and multiple nodes were identified in 108 (51.4%). Multivariate analysis revealed that vital capacity < 80% (hazard ratio [HR]: 2.678, 95% confidence interval [CI]: 1.483-4.837), radiological usual interstitial pneumonia pattern (HR: 2.321, 95% CI: 1.506-3.576), tumor size > 4.0 cm (HR: 1.534, 95% CI: 1.035-2.133), and multiple-node metastases (HR: 2.283, 95% CI: 1.517-3.955) were significant independent risk factors for poor OS. Tumor size > 4.0 cm (HR: 1.780, 95% CI: 1.237-2.562), lymphatic permeation (HR: 1.525, 95% CI: 1.053-2.207), and multiple lymph node metastases (HR: 2.858, 95% CI: 1.933-4.226) were significant independent risk factors for recurrence. In patients with squamous cell carcinoma (n = 93), there were no significant differences in OS or RFP between those who received platinum-based adjuvant chemotherapy (n = 25) and those who did not (n = 68), at p = 0.690 and p = 0.292, respectively. Multiple-node metastases were independent predictors of poor OS and recurrence. Patients with NSCLC and single-node metastases should be considered for surgery despite N2 disease. Additional treatment with platinum-based adjuvant chemotherapy may be expected, especially in patients with squamous cell carcinoma.

    DOI： 10.3390/cancers15123098

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  • [Analysis of Surgical Margin Recurrence Following Segmentectomy for Early-stage Non-small Cell Lung Cancer].

    Tatsuya Goto, Mika Miyajima, Masaya Nakamura, Yuki Shimizu, Terumoto Koike, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   76 ( 1 )   84 - 89   2023.1

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Surgical margin recurrence following segmentectomy is a critical issue because it may have been avoided by lobectomy. METHODS: Between January 2000 and December 2018, we retrospectively investigated 199 patients who underwent segmentectomy for c-StageⅠ non-small cell lung cancer at our hospital. RESULTS: Recurrence occurred in 20 cases, of which 3 cases had surgical margin recurrence. In our previous study, the recurrence risk factor after segmentectomy was radiologic solid tumor size( cut-off value 1.5 cm). Of the 130 patients in the low-risk group with radiologic solid tumor size of less than 1.5 cm, five had any recurrence, three of which had surgical margin recurrence. In the high-risk group with radiologic solid tumor size of 1.5 cm or more, no surgical margin recurrence was observed. Three cases of surgical margin recurrence were accompanied by lepidic components, and the tumors were difficult to identify intraoperatively and were located close to adjacent areas. CONCLUSION: Surgical margin recurrence may be avoided by carefully considering the segments to be resected and improving the method for identifying the intersegmental plane.

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  • Maximum Standardized Uptake Value on Positron Emission Tomography is Associated With More Advanced Disease and High-risk Features in Lung Adenocarcinoma. International journal

    Terumoto Koike, Noriaki Sato, Yuta Hosoda, Masayuki Tazawa, Tatsuya Goto, Seijiro Sato, Motohiko Yamazaki, Shin-Ichi Toyabe, Masanori Tsuchida

    Seminars in thoracic and cardiovascular surgery   34 ( 3 )   1051 - 1060   2021.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) has been widely used for preoperative staging of lung adenocarcinomas. The aim of this study was to determine whether a high maximum standardized uptake value (SUVmax) could correlate with pathological characteristics in those patients. We retrospectively reviewed patients with clinical stage 0-IA lung adenocarcinoma who underwent preoperative 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography followed by curative anatomical resection. To identify more advanced disease and high-risk features, representing visceral pleural involvement, pulmonary metastasis, lymph node involvement, and lymphovascular involvement in resected surgical specimens, univariate and multivariate logistic regression analyses were performed. The optimal cutoff point for the SUVmax was determined by receiver operating characteristic analysis. In 2 groups divided according to the cutoff point, the disease-free survivals were calculated and compared using the Kaplan-Meier method and the log-rank test. More advanced disease and high-risk features were identified in 55 (18.9%) of the 291 patients. SUVmax was significantly correlated with more advanced disease and high-risk features, as did the consolidation/tumor ratio on computed tomography. Only 2 (1.2%) of the 169 patients with a SUVmax <3.20 showed more advanced disease and high-risk features, compared with 43.4% of patients with a SUVmax ≥3.20. The disease-free survival was significantly higher in patients with a SUVmax <3.20 than in those with a SUVmax ≥3.20 (P = 0.002). A high SUVmax correlates with more advanced disease and high-risk features in patients with clinical stage 0-IA lung adenocarcinoma. The SUVmax should be considered when deciding treatment strategy in early-stage lung adenocarcinoma.

    DOI： 10.1053/j.semtcvs.2021.07.019

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  • Surgical outcomes of ipsilateral metachronous second primary lung cancer

    Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Takahisa Koizumi, Takehiro Watanabe, Hirohiko Shinohara, Yasushi Yamato, Masanori Tsuchida

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   32 ( 6 )   896 - 903   2021.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：OXFORD UNIV PRESS  

    OBJECTIVES: The optimal surgical approach for metachronous second primary lung cancer (MSPLC), especially ipsilateral MSPLC, remains unclear. This study aimed to review postoperative complications and examine surgical outcomes based on the extent of resection after surgery for ipsilateral MSPLC.METHODS: Clinical data from 61 consecutive patients who underwent pulmonary resection for ipsilateral MSPLC according to the Martini-Melamed criteria between January 2005 and December 2017 in 3 institutes were retrospectively reviewed.RESULTS: Postoperative complications were identified in 12 patients (19.7%). Regarding the combination of initial and second surgery, intraoperative bleeding was significantly greater in patients with anatomic-anatomic resection than in others (P < 0.001). Operation time was significantly longer in patients with anatomic-anatomic resection than in others (P <0.001). However, postoperative complications showed no significant differences based on the combination of surgeries. Five-year overall survival rates in patients with anatomic resection and wedge resection after second surgery were 75.8% and 75.8%, respectively (P= 0.738), and 5-year recurrence-free survival rates were 54.2% and 67.6%, respectively (P = 0.368). Cox multivariate analysis identified ever-smoker status (P = 0.029), poor performance status (P = 0.011) and tumour size >20 mm (P = 0.001) as independent predictors of poor overall survival, while ever-smoker status (P = 0.040) and tumour size >20 mm (P = 0.007) were considered independent predictors of poor recurrence-free survival.CONCLUSIONS: Regarding postoperative and long-term outcomes for patients with ipsilateral MSPLC, surgical intervention is safe and offers good long-term survival. Wedge resection is an acceptable provided tumours <= 2 cm and ground-glass opacity-predominant as a second surgery for early-stage ipsilateral MSPLC.

    DOI： 10.1093/icvts/ivab025

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  • Surgical outcomes of ipsilateral metachronous second primary lung cancer. International journal

    Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Takahisa Koizumi, Takehiro Watanabe, Hirohiko Shinohara, Yasushi Yamato, Masanori Tsuchida

    Interactive cardiovascular and thoracic surgery   32 ( 6 )   896 - 903   2021.5

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    OBJECTIVES: The optimal surgical approach for metachronous second primary lung cancer (MSPLC), especially ipsilateral MSPLC, remains unclear. This study aimed to review postoperative complications and examine surgical outcomes based on the extent of resection after surgery for ipsilateral MSPLC. METHODS: Clinical data from 61 consecutive patients who underwent pulmonary resection for ipsilateral MSPLC according to the Martini-Melamed criteria between January 2005 and December 2017 in 3 institutes were retrospectively reviewed. RESULTS: Postoperative complications were identified in 12 patients (19.7%). Regarding the combination of initial and second surgery, intraoperative bleeding was significantly greater in patients with anatomic-anatomic resection than in others (P < 0.001). Operation time was significantly longer in patients with anatomic-anatomic resection than in others (P < 0.001). However, postoperative complications showed no significant differences based on the combination of surgeries. Five-year overall survival rates in patients with anatomic resection and wedge resection after second surgery were 75.8% and 75.8%, respectively (P = 0.738), and 5-year recurrence-free survival rates were 54.2% and 67.6%, respectively (P = 0.368). Cox multivariate analysis identified ever-smoker status (P = 0.029), poor performance status (P = 0.011) and tumour size >20 mm (P = 0.001) as independent predictors of poor overall survival, while ever-smoker status (P = 0.040) and tumour size >20 mm (P = 0.007) were considered independent predictors of poor recurrence-free survival. CONCLUSIONS: Regarding postoperative and long-term outcomes for patients with ipsilateral MSPLC, surgical intervention is safe and offers good long-term survival. Wedge resection is an acceptable provided tumours ≤2 cm and ground-glass opacity-predominant as a second surgery for early-stage ipsilateral MSPLC.

    DOI： 10.1093/icvts/ivab025

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  • Radical segmentectomy as a potential alternative surgical treatment with curative intent in early-stage non-small cell lung cancer. International journal

    Terumoto Koike, Tatsuya Goto, Seijiro Sato, Masanori Tsuchida

    Journal of thoracic disease   12 ( 10 )   6115 - 6119   2020.10

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  • Characteristics and risk factors of recurrence in clinical stage I non-small cell lung cancer patients undergoing anatomic segmentectomy.

    Terumoto Koike, Akihiro Nakamura, Yuki Shimizu, Tatsuya Goto, Seijiro Sato, Shin-Ichi Toyabe, Masanori Tsuchida

    General thoracic and cardiovascular surgery   68 ( 9 )   1011 - 1017   2020.9

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    OBJECTIVE: Although lobectomy is the standard surgical procedure for small-sized non-small cell lung cancer (NSCLC), segmentectomy has been performed for various reasons. The aim of this study was to investigate the characteristics of and risk factors for recurrence in early-stage NSCLC patients undergoing segmentectomy. METHODS: We retrospectively reviewed 179 patients with clinical stage I NSCLC who underwent segmentectomy. Preoperative factors were analyzed using the log-rank test for univariate analyses. Multivariate analyses were performed using a Cox proportional hazards regression model to identify independent risk factors for recurrence. For the significant factors, optimal cutoff points were determined by receiver operating characteristic (ROC) analysis. RESULTS: During the follow-up period of 51 months, 18 patients developed recurrence; 5 had locoregional (including 2 with margin recurrences only), 9 had distant, and 4 had both locoregional and distant recurrence. Multivariate and ROC analysis identified radiologic solid tumor size with a cutoff point of 1.5 cm as an independent risk factor for recurrence. Three patients in the solid size < 1.5 cm group (n = 119) developed recurrence, 2 of whom had surgical margin recurrence, compared to 15 patients in the solid size ≥ 1.5 cm group (n = 60). CONCLUSIONS: The indication for segmentectomy should be decided upon with caution, and the segments to be resected should be carefully considered to secure an appropriate surgical margin in this low-risk subgroup of patients because they may have a relatively higher risk of surgical margin recurrence, despite being at decreased risk.

    DOI： 10.1007/s11748-020-01338-x

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  • Impact of postoperative complications on outcomes of second surgery for second primary lung cancer.

    Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Masanori Tsuchida

    Surgery today   50 ( 11 )   1452 - 1460   2020.6

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    PURPOSE: The best surgical approach for second primary lung cancer remains a subject of debate. The purpose of this study was to review the postoperative complications after second surgery for second primary lung cancer and to investigate the outcomes based on these complications. METHODS: The clinical data of 105 consecutive patients who underwent pulmonary resection for multiple primary lung cancers between January, 1996 and December, 2017, were reviewed according to the Martini-Melamed criteria. RESULTS: After the second surgery, low body mass index (BMI) (< 18.5 kg/m2) (P = 0.004) and high Charlson comorbidity index (CCI) (P = 0.002) were independent predictors of postoperative complications. Survival analysis revealed the 5-year overall survival rates of 74.5% and 61.4% for patients without postoperative complications and those with postoperative complications (P = 0.044), respectively, but the 5-year cancer-specific survival rates of 82.5% and 80.0% (P = 0.926), respectively. During this period, there were significantly more respiratory-related deaths of patients with complications than of those without complications (P = 0.011). CONCLUSION: Surgical intervention is feasible and potentially effective for second primary lung cancer but may not achieve positive perioperative and long-term outcomes for patients with a low BMI or a high CCI. Treatment options should be considered carefully for these patients.

    DOI： 10.1007/s00595-020-02038-y

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  • [Thoracoscopic Left Upper Division Segmentectomy for Multiple Ground-glass Nodules Using Preoperative Virtual-assisted Lung Mapping].

    Yuki Shimizu, Masaya Nakamura, Tatsuya Goto, Seijiro Sato, Terumoto Koike, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   72 ( 7 )   528 - 533   2019.7

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Associated with an increase of small-sized lung cancer or metachronous second primary lung cancer, we have more opportunities to perform sublobar resection. Difficulties of identifying tumor location and appropriate surgical margin for small-sized ground-glass opacity (GGO) dominant lesions in thoracoscopic surgery is the big issue of sublobar resection. Virtual-assisted lung mapping (VAL-MAP) that makes markings on the lung surface through some peripheral bronchi by bronchoscopically projects intrapulmonary anatomy on the lung surface and literally draw a map. We report a case of thoracoscopic left upper division segmentectomy for multiple ground-glass nodules (GGNs) using preoperative VAL-MAP. A 65-year-old women who had undergone right upper lobectomy for primary lung cancer, and had multiple GGNs in the bilateral lungs was followed up as an outpatient. Eleven years after initial pulmonary resection, 2 lesions in the left upper division became bigger, and we decided to perform surgery for 4 GGNs in the left upper division including these 2 lesions. We preoperatively made bronchoscopic dye markings through B1+2c, B3a and B4a for in the left upper lobe. The 3 markings were intraoperatively identified. We decided the resection line based on the markings and performed thoracoscopic left upper division segmentectomy. The pathological diagnosis was minimally invasive adenocarcinoma, adenocarcinoma in situ and pneumonitis. Surgical margins were negative. VAL-MAP will assume an important role as an intraoperative navigation system for sublobar resection.

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  • 【肺区域・亜区域・複雑区域切除の工夫と実際】VAL-MAP法 Virtual-assisted lung mapping(VAL-MAP)を用いた多発肺野限局性スリガラス結節に対する胸腔鏡下左上区切除

    清水 勇希, 中村 将弥, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    胸部外科   72 ( 7 )   528 - 533   2019.7

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    Language：Japanese   Publisher：(株)南江堂  

    65歳女。胸部CT異常影を主訴とした。右肺上葉切除術後の多発スリガラス結節(GGN)症例であり、胸部CTでは左肺S1+2a末梢に2ヵ所、左肺S3c末梢とS3aにそれぞれGGNを認め、いずれも肺癌の可能性があったため、全ての病変を含むよう区域切除を選択した。また、S3aの病変は術中触知困難が予想され、左肺S4+5との区域間に近接していたため、切離ラインの設定補助目的でvirtual-assisted lung mapping(VAL-MAP)を用い、胸腔鏡下左上区切除を行った結果、病変からのマージンを確保しつつ、残存区域の損失を最小限にするよう胸腔鏡下に完全切除できた。術後5年で再発はなく、残存するGGN病変も著変なく経過している。VAL-MAPは触知困難病変に対する胸腔鏡下区域切除において、特に有用であった。

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  • Early and mid-term outcomes of simultaneous thoracic endovascular stent grafting and combined resection of thoracic malignancies and the aortic wall.

    Seijiro Sato, Atsuhiro Nakamura, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Takeshi Okamoto, Masanori Tsuchida

    General thoracic and cardiovascular surgery   67 ( 2 )   227 - 233   2019.2

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    OBJECTIVES: To aim of this study was to clarify the safety of simultaneous thoracic aortic endografting and combined resection of the aortic wall and thoracic malignancy in a one-stage procedure over the early and mid-term periods. METHODS: From March 2013 to December 2017, 6 patients underwent aortic endografting followed by one-stage en bloc resection of the tumor and aortic wall. Thoracic surgeons and cardiovascular surgeons discussed predicted tumor invasion range and resection site, stent placement position, stent length and size, and the surgical procedure, taking into account the safe margin. RESULTS: The proximal site of aortic endografting was the: aortic arch in 2 cases (subclavian artery (SCA) occlusion in one, and SCA fenestration in one); distal arch just beneath the SCA in 2; descending aorta in 2. Pulmonary resection involved lobectomy in 2 patients, pneumonectomy in 2, and completion pneumonectomy in 1. Aortic resection was limited to the adventitia in 2 cases, extended to the media in 3, and extended to the intima in 1. An endograft-related complication, external iliac artery intimal damage requiring vessel repair, was observed in one case. No complications associated with aortic resection were observed. Two postoperative complications of atrial fibrillation and chylothorax developed. There were no surgery-related deaths. During follow-up, no late endograft-related complications such as migration or endoleaks occurred. CONCLUSIONS: Early and mid-term outcomes of stent graft-related complications are acceptable. Simultaneous thoracic aortic endografting and combined resection of the aortic wall and thoracic malignancies are feasible in one stage on the same day.

    DOI： 10.1007/s11748-018-1003-1

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  • A multicenter prospective observational study of the safety and prognosis of lung cancer patients with idiopathic pulmonary fibrosis following surgery: Niigata Chest Surgery Study Group Reviewed

    12 ( 7 )   782 - 791   2018.11

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    Authorship：Lead author   Language：Japanese  

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  • Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study. International journal

    Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe, Masanori Tsuchida

    BMC pulmonary medicine   18 ( 1 )   134 - 134   2018.8

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    BACKGROUND: Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this study was to evaluate the surgical outcomes of repeated lung cancer surgery in patients with IPF. METHODS: From January 2001 to December 2015, 108 lung cancer patients with IPF underwent pulmonary resection at two institutions; 13 of these patients underwent repeated surgery for lung cancer, and their data were reviewed. RESULTS: The initial procedures of the 13 patients were lobectomy in 8, segmentectomy in 2, and wedge resection in 3. The subsequent procedures were wedge resection in 10 and segmentectomy in 3. The clinical stage of the second tumor was stage IA in 12 and stage IB in 1. Postoperatively, 3 patients (23.1%) developed acute exacerbation (AE) of IPF and died. The rate of decrease in percent vital capacity was significantly higher in patients with AE than in those without AE (p = 0.011). The 3-year overall survival rate was 34.6%. The causes of death were cancer-related in 7, AE of IPF in 3, and metachronous lung cancer in 1. CONCLUSIONS: Despite limited resection, a high incidence of AE was identified. The early and long-term outcomes of repeated surgery in lung cancer patients with IPF were poor because of the high risk of AE of IPF and lung cancer recurrence. Long-term intensive surveillance will be required to determine whether surgical intervention is justified in patients with multiple primary lung cancers and IPF.

    DOI： 10.1186/s12890-018-0703-8

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  • Surgical resection of a giant polycystic seminoma of the mediastinum International journal

    Tatsuya Goto, Seijiro Sato, Terumoto Koike, Masanori Tsuchida

    Journal of Thoracic Disease   10 ( 6 )   E438 - E441   2018.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：AME Publishing Company  

    DOI： 10.21037/jtd.2018.05.79

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  • Strategy of intentional limited resection for lung adenocarcinoma in situ. International journal

    Terumoto Koike, Teruaki Koike, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Seijiro Sato, Masanori Tsuchida

    Journal of thoracic disease   10 ( Suppl 17 )   S2018-S2021   2018.6

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  • 左肺全摘術と右主肺動脈再建にて完全切除した左主肺動脈血管肉腫の1手術例

    北原 哲彦, 清水 勇希, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   32 ( 4 )   492 - 499   2018.5

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    Language：Japanese   Publisher：(NPO)日本呼吸器外科学会  

    症例は64歳女性。子宮体癌の破裂により当院を受診した。緊急で子宮切除が行われたが、その際のCTで深部静脈血栓と右肺動脈血栓、左肺動脈内の塞栓子を認めた。子宮体癌術後下大静脈フィルターと抗凝固薬にて治療が行われた。抗凝固療法により右肺動脈内の血栓は消失したが、左肺動脈の塞栓子は消失しなかった。その後塞栓子は徐々に増大を認めた。PET/CTでは同病変に集積を認め、心臓カテーテル検査での腫瘍生検により血管肉腫と診断された。胸骨正中切開で体外循環を併用し、左主肺動脈切除と左肺全摘、右主肺動脈再建を行った。病理では血管内膜由来の肉腫であることが判明した。術後8ヵ月目に再発を認め、9ヵ月後に肺炎による呼吸不全で死亡した。肺動脈肉腫は稀な疾患であり、文献的考察を加え報告する。(著者抄録)

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  • Characteristics and timing of recurrence during postoperative surveillance after curative resection for lung adenocarcinoma.

    Terumoto Koike, Tatsuya Goto, Akihiko Kitahara, Seijiro Sato, Masayuki Saitoh, Takehisa Hashimoto, Osamu Namura, Masashi Takahashi, Shin-Ichi Toyabe, Masanori Tsuchida

    Surgery today   47 ( 12 )   1469 - 1475   2017.12

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    PURPOSE: To establish the most effective methods of postoperative surveillance to detect early recurrence of lung adenocarcinoma. METHODS: The subjects of this retrospective study were 485 patients with p-stage I-III lung adenocarcinoma, who underwent postoperative surveillance. We examined the sites and detection modes of recurrence and calculated the recurrence-free probabilities. Patients with stage I disease were divided into low- and high-risk recurrence groups using a risk score calculated by assigning points proportional to risk factor regression coefficients. RESULTS: Of the 112 patients with recurrence, 86 had intrathoracic recurrence. Routine computed tomography (CT) revealed recurrence in 60 patients. The recurrence-free probability curves showed that 95% of recurrences were identified within the first 4 years after resection in patients with stage II/III disease. In patients with stage I disease, the predictors of recurrence included male sex, positive pleural lavage cytology, moderate-to-poor differentiation, and visceral pleural invasion. Postoperative recurrences were detected throughout the follow-up period in the high-risk group. CONCLUSIONS: Routine chest CT plays an important role in the postoperative surveillance of lung adenocarcinoma. We recommend intensive follow-up during the early post-resection period for patients with advanced stage disease and long-term follow-up for high-risk patients with stage I disease.

    DOI： 10.1007/s00595-017-1537-3

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  • One-stage surgery in combination with thoracic endovascular grafting and resection of T4 lung cancer invading the thoracic aorta and spine. International journal

    Seijiro Sato, Tatsuya Goto, Terumoto Koike, Takeshi Okamoto, Hirokazu Shoji, Masayuki Ohashi, Kei Watanabe, Masanori Tsuchida

    Journal of thoracic disease   9 ( 11 )   E1009-E1012   2017.11

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    A novel strategy of one-stage surgery in combination with thoracic endovascular grafting and resection for T4 lung cancer invading the thoracic aorta and spine is described. A 56-year-old man with locally advanced lung cancer infiltrating the aortic wall and spine underwent neoadjuvant chemotherapy and thoracic irradiation, followed by en bloc resection of the aortic wall and spine with thoracic endovascular grafting. He developed postoperative chylothorax, but there were no stent graft-related events. After 3 months, computed tomography (CT) did not show aortic stent graft stenosis, migration, or deformation.

    DOI： 10.21037/jtd.2017.10.101

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  • Is segmentectomy indicative for small-sized non-small cell lung cancer in the basal segments with a small ground-glass opacity component? International journal

    Terumoto Koike, Akihiro Nakamura, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Seijiro Sato, Masanori Tsuchida

    Journal of thoracic disease   9 ( 10 )   3501 - 3505   2017.10

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  • Open Drainage with Vacuum Assisted Closure (VAC) Therapy for Aspergillus Empyema after Left Upper Lobectomy with Adjuvant Radiotherapy Reviewed

    66 ( 13 )   1171 - 1174   2013.12

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    Authorship：Lead author   Language：Japanese  

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  • 左上葉転位気管支領域に発生した左上葉肺癌に対して胸腔鏡下左S1+2区域切除を施行した1例

    小林 遼平, 土田 正則, 小池 輝元, 後藤 達哉, 清水 勇希, 中村 将弥, 田中 博, 瀬崎 遼

    日本胸部外科学会関東甲信越地方会要旨集   ( 187回 )   27 - 27   2021.11

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  • 化学放射線療法後にサルベージ手術を施行したN3肺尖部胸壁浸潤癌の1例

    清水 勇希, 中村 将弥, 後藤 達哉, 小池 輝元, 土田 正則

    肺癌   61 ( 6 )   714 - 714   2021.10

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  • IIIB期肺腺癌の化学放射線療法後の局所再発に対しサルベージ手術を施行した1症例

    中村 将弥, 田中 博, 瀬崎 遼, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    肺癌   61 ( 6 )   713 - 713   2021.10

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  • 右上葉切除後の右下葉肺腺癌に対し右S8+9区域切除を施行した一例

    中村 将弥, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 186回 )   38 - 38   2021.6

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  • 間質性肺炎合併肺癌における非癌部間質性肺炎領域が周術期に与える影響

    佐藤 征二郎, 田澤 勝幸, 細田 裕太, 後藤 達哉, 小池 輝元, 篠原 博彦, 土田 正則

    日本呼吸器外科学会雑誌   35 ( 3 )   O5 - 4   2021.5

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  • 原発性肺腺癌におけるFDG-PET/CTでのDeauville分類の有用性の検討

    田澤 勝幸, 細田 裕太, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   35 ( 3 )   MO1 - 2   2021.5

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  • 右肺下葉切除術後左主気管支食道瘻に対して上部消化管内視鏡的クリッピングで治癒し得た一例

    細田 裕太, 田澤 勝幸, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 185回 )   20 - 20   2021.3

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  • 気管原発腺様嚢胞癌に対しV-V ECMO下で気管切除・再建を施行した一例

    細田 裕太, 後藤 達哉, 田澤 勝幸, 佐藤 哲彰, 大久保 由華, 佐藤 征二郎, 三島 健人, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 184回 )   18 - 18   2020.11

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  • 肺癌切除に起因する術後早期胸腔内合併症に対する緊急残存肺全摘の経験

    土田 正則, 田澤 勝幸, 細田 裕太, 後藤 達哉, 佐藤 征二郎, 小池 輝元

    日本胸部外科学会定期学術集会   73回   LOO14 - 35   2020.10

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  • 非小細胞肺癌根治切除症例において術後末梢血好中球/リンパ球比の意義の検討

    田澤 勝幸, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会定期学術集会   73回   LOO15 - 10   2020.10

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  • 慢性閉塞性肺疾患合併非小細胞肺癌における気腫病変の意義

    佐藤 征二郎, 田澤 勝幸, 細田 裕太, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    日本胸部外科学会定期学術集会   73回   LOO1 - 24   2020.10

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  • 上肺静脈心嚢内結紮を行った左肺上葉切除症例の検討

    北原 哲彦, 清水 勇希, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   34 ( 3 )   MO4 - 3   2020.8

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  • 増大する両側多発肺結節を伴った縦隔原発Growing teratoma syndromeの1切除例

    中村 将弥, 佐藤 征二郎, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    肺癌   59 ( 3 )   325 - 325   2019.6

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  • 肺分画症に対する胸腔鏡下左底区切除後の肺静脈還流障害の1例

    清水 勇希, 中村 将弥, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 180回 )   25 - 25   2019.6

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  • The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study. International journal

    Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Hiroyuki Ishikawa, Masanori Tsuchida

    BMC pulmonary medicine   19 ( 1 )   73 - 73   2019.4

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    BACKGROUND: The presence of emphysema on computed tomography (CT) is associated with an increased frequency of lung cancer, but the postoperative outcomes of patients with pulmonary emphysema are not well known. The objective of this study was to investigate the association between the extent of emphysema and long-term outcomes, as well as mortality and postoperative complications, in early-stage lung cancer patients after pulmonary resection. METHODS: The clinical records of 566 consecutive lung cancer patients who underwent pulmonary resection in our department were retrospectively reviewed. Among these, the data sets of 364 pathological stage I patients were available. The associations between the extent of lung emphysema and long-term outcomes and postoperative complications were investigated. Emphysema was assessed on the basis of semiquantitative CT. Surgery-related complications of Grade ≥ II according to the Clavien-Dindo classification were included in this study. RESULTS: Emphysema was present in 63 patients. The overall survival and relapse-free survival of the non-emphysema and emphysema groups at 5 years were 89.0 and 61.3% (P < 0.001), respectively, and 81.0 and 51.7%, respectively (P < 0.001). On multivariate analysis, significant prognostic factors were emphysema, higher smoking index, and higher histologic grade (p < 0.05). Significant risk factors for poor recurrence-free survival were emphysema, higher smoking index, higher histologic grade, and presence of pleural invasion (P < 0.05). Regarding Grade ≥ II postoperative complications, pneumonia and supraventricular tachycardia were more frequent in the emphysema group than in the non-emphysema group (P = 0.003 and P = 0.021, respectively). CONCLUSION: The presence of emphysema affects the long-term outcomes and the development of postoperative complications in early-stage lung cancer patients.

    DOI： 10.1186/s12890-019-0839-1

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  • 進行肺癌に対する分子標的治療薬使用後サルベージ手術を施行した2例

    中村 将弥, 佐藤 征二郎, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   33 ( 3 )   P70 - 5   2019.4

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  • 肺癌同側解剖学的手術例における周術期成績

    清水 勇希, 佐藤 征二郎, 中村 将弥, 後藤 達哉, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   33 ( 3 )   O15 - 1   2019.4

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  • 臨床病期IA期非小細胞肺癌患者におけるFDG-PET/CTによる病理学的浸潤・転移の予測

    小池 輝元, 中村 将弥, 清水 勇希, 後藤 達哉, 佐藤 征二郎, 土田 正則

    日本呼吸器外科学会雑誌   33 ( 3 )   P16 - 1   2019.4

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  • 術後合併症リスクから考える第二原発肺癌に対する治療戦略

    佐藤 征二郎, 中村 将弥, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   33 ( 3 )   P58 - 1   2019.4

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  • 術前導入化学放射線療法後に気管支肺動脈一括処理および左房合併切除を施行した原発性肺癌の1例

    清水 勇希, 中村 将弥, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 179回 )   17 - 17   2019.3

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  • 術後再発形式から見る早期非小細胞肺癌に対する区域切除の妥当性の検討

    小池 輝元, 仲村 亮宏, 清水 勇希, 後藤 達哉, 佐藤 征二郎, 土田 正則

    肺癌   58 ( 6 )   532 - 532   2018.10

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  • 多臓器合併切除の新しいアプローチ/診療科をまたぐ合併切除の試み 大動脈浸潤肺癌に対する人工心肺を用いないTEVAR下大動脈合併切除

    土田 正則, 中村 将弥, 仲村 亮宏, 清水 勇希, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 岡本 竹司, 小池 輝元

    肺癌   58 ( 6 )   445 - 445   2018.10

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  • 気腫病変の存在は肺癌手術成績を予測できるか

    中村 将弥, 佐藤 征二郎, 清水 勇希, 後藤 達哉, 小池 輝元, 土田 正則

    肺癌   58 ( 6 )   766 - 766   2018.10

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  • 術前動脈塞栓術を行い切除した胸腔内巨大孤立性線維性腫瘍の1例

    清水 勇希, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 177回 )   21 - 21   2018.6

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  • 末梢小型肺癌における区域切除後遠隔期の課題 病理学的浸潤・転移のリスク因子を有する早期非小細胞肺癌患者に対する縮小手術の成績

    小池 輝元, 清水 勇希, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 土田 正則

    日本呼吸器外科学会雑誌   32 ( 3 )   PD2 - 6   2018.4

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  • 臨床病期I期原発性肺癌における区域切除後の再発に関する検討

    仲村 亮宏, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本外科学会定期学術集会抄録集   118回   2518 - 2518   2018.4

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  • 半定量的CT評価法に基づく気腫病変存在程度から観た原発性肺癌手術成績

    佐藤 征二郎, 清水 勇希, 後藤 達哉, 北原 哲彦, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   32 ( 3 )   O4 - 1   2018.4

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  • 半定量的CT評価法に基づく気腫病変存在程度から観たCOPD合併肺癌の検討

    清水 勇希, 佐藤 征二郎, 後藤 達哉, 北原 哲彦, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   32 ( 3 )   O9 - 6   2018.4

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  • リンパ節転移を有する扁平上皮癌患者の再発・予後に関する検討

    後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   32 ( 3 )   P11 - 2   2018.4

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  • 第2肺癌に対する術後合併症リスクについて考える

    佐藤 征二郎, 清水 勇希, 仲村 亮宏, 後藤 達哉, 北原 哲彦, 小池 輝元, 土田 正則

    日本外科学会定期学術集会抄録集   118回   2148 - 2148   2018.4

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  • SVC合併切除・グラフト置換を施行した胸腺癌の1手術例

    清水 勇希, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 176回 )   21 - 21   2018.3

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  • 特異な進展を示した類基底細胞癌の1例

    鈴木 脩平, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    肺癌   58 ( 1 )   69 - 69   2018.2

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  • N2-IIIA期肺腺癌に対して術前導入療法によって左肺全摘を回避しえた1例

    仲村 亮宏, 後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 175回 )   16 - 16   2017.11

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  • 縦隔原発malignant peripheral nerve sheath tumorの1切除例

    清水 勇希, 佐藤 征二郎, 後藤 達哉, 小池 輝元, 土田 正則, 梅津 哉

    肺癌   57 ( 6 )   801 - 801   2017.11

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  • 生体肺移植遠隔期の高度BOSにおける繰り返す無気肺の1例

    後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    移植   52 ( 2-3 )   246 - 246   2017.9

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  • 次世代シーケンサーを用いた併存遺伝子変異の影響

    佐藤 征二郎, 後藤 達哉, 北原 哲彦, 小池 輝元, 高田 和樹, 岡本 龍郎, 土田 正則

    肺癌   57 ( 5 )   555 - 555   2017.9

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  • 左上下葉気管支分岐部にポリープ状に発生した炎症性偽腫瘍の1例

    清水 勇希, 佐藤 征二郎, 後藤 達哉, 小池 輝元, 土田 正則, 林 正周, 穂苅 諭, 菊池 利明, 大橋 瑠子

    気管支学   39 ( 4 )   370 - 370   2017.7

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  • 左上葉切除後の異時多発肺がんSBRT後再発に対する残存肺全摘、大動脈合併切除の1例

    田代 啓太, 仲村 亮宏, 後藤 達哉, 中村 制士, 佐藤 征二郎, 岡本 竹司, 小池 輝元, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 174回 )   8 - 8   2017.6

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  • 左肺全摘術+右主肺動脈再建にて完全切除した左主肺動脈intimal sarcomaの1手術例

    後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   31 ( 3 )   RV1 - 3   2017.4

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  • 局所進行T4肺癌に対する大動脈遠位弓部合併切除および椎体合併切除再建術

    佐藤 征二郎, 後藤 達哉, 北原 哲彦, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   31 ( 3 )   RV4 - 6   2017.4

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  • NSCLC切除例におけるPET/CTを用いたMetabolic tumor volumeとTotal lesion glycolysisの有用性の検討

    後藤 達哉, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則

    日本呼吸器外科学会雑誌   31 ( 3 )   P82 - 3   2017.4

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  • 巨大anterior mediastinal cystic seminomaの1手術例

    北原 哲彦, 仲村 亮宏, 後藤 達哉, 佐藤 征二郎, 小池 輝元, 土田 正則

    肺癌   57 ( 2 )   131 - 131   2017.4

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  • 周囲臓器の高度圧排を認めた巨大右肺癌の1手術例

    後藤 達哉, 佐藤 征二郎, 小池 輝元, 名村 理, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 173回 )   24 - 24   2017.3

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  • 術前生検にて診断がついた左主肺動脈血管肉腫の1手術例

    後藤 達哉, 仲村 亮宏, 大久保 由華, 佐藤 征二郎, 小池 輝元, 白石 修一, 名村 理, 土田 正則

    日本胸部外科学会関東甲信越地方会要旨集   ( 172回 )   21 - 21   2016.11

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    Language：Japanese   Publisher：日本胸部外科学会-関東甲信越地方会  

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  • 次世代シーケンサーを用いた原発性肺腺癌切除例の網羅的遺伝子発現解析に基づく治療

    佐藤 征二郎, 後藤 達哉, 北原 哲彦, 小池 輝元, 高田 和樹, 岡本 龍郎, 前原 喜彦, 土田 正則

    肺癌   56 ( 6 )   515 - 515   2016.11

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    Language：Japanese   Publisher：(NPO)日本肺癌学会  

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  • 若年女性に発症した多発肺硬化性血管腫の1例

    仲村 亮宏, 佐藤 征二郎, 後藤 達哉, 北原 哲彦, 小池 輝元, 土田 正則, 梅津 哉

    肺癌   56 ( 4 )   326 - 326   2016.8

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    Language：Japanese   Publisher：(NPO)日本肺癌学会  

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  • 著明な右心不全を呈した心室ペースメーカリードによる三尖弁閉鎖不全症に対して三尖弁形成術を施行した1例

    三島 健人, 後藤 達哉, 島田 晃治, 大関 一

    心臓   46 ( 6 )   742 - 746   2014.6

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    Language：Japanese   Publisher：(公財)日本心臓財団  

    症例は74歳男性。1991年に洞不全症候群に対してVVIペースメーカ埋め込み、1995年にリード断裂に対しリードの追加を施行。2009年にジェネレータ交換のために入院した際、顔面浮腫、腹部膨満あり、三尖弁閉鎖不全(TR)4度を指摘された。2011年4月肝障害、腎不全をきたし入院。ペースメーカによる高度のTRが症状の原因と考えられ手術となった。術前のCT検査では腹水を認め、心エコー検査では、三尖弁尖は離開しTR4度を認め、また僧帽弁閉鎖不全(MR)2度も認めた。人工心肺心停止下に僧帽弁輪の形成術を施行した後、三尖弁を観察すると、2本のリードのうち使用していない古いリードが後尖とその腱索に癒着し後尖の動きを妨げていた。この癒着を剥離し、古いリードを抜去した。三尖弁の弁尖に明らかな異常は認められず、著明な三尖弁輪の拡大に対し弁輪形成を施行した。使用しているリードはそのまま温存できた。術後の心エコー検査でMRは消失、TRは1度となり、腹部膨満は著明に改善した。ペースメーカ移植後に重度のTRから著明な右心不全をきたし手術にいたる症例は稀と思われる。また、2本のリードの1本のみ抜去し、1本を温存し三尖弁を修復した手術の報告は認められず、稀な症例と考え若干の考察を加え報告した。(著者抄録)

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    Other Link： https://search.jamas.or.jp/default/link?pub_year=2014&ichushi_jid=J00679&link_issn=&doc_id=20140623230015&doc_link_id=%2Fah2sinzd%2F2014%2F004606%2F017%2F0742-0746%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fah2sinzd%2F2014%2F004606%2F017%2F0742-0746%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 下大静脈平滑筋肉腫に対する手術治療の経験

    後藤 達哉, 三島 健人, 斉藤 正幸, 島田 晃治, 大関 一, 若木 邦彦

    新潟医学会雑誌   127 ( 3 )   161 - 161   2013.3

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  • 胸部大動脈瘤に対する弓部置換術における腎保護法の工夫

    後藤 達哉, 三島 健人, 斎藤 正幸, 島田 晃治, 大関 一

    新潟医学会雑誌   127 ( 2 )   118 - 118   2013.2

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  • 著明な右心不全を呈した心室ペーシングリードによる三尖弁閉鎖不全症に対して三尖弁形成術を施行した1例

    三島 健人, 後藤 達哉, 島田 晃治, 大関 一

    新潟医学会雑誌   126 ( 8 )   440 - 441   2012.8

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  • 孤立性腹部内臓動脈解離5例の検討

    三島 健人, 後藤 達哉, 島田 晃治, 大関 一

    日本血管外科学会雑誌   21 ( 3 )   474 - 474   2012.5

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    Language：Japanese   Publisher：(NPO)日本血管外科学会  

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MISC

Research Projects

  • 放射線・病理画像テクスチャ解析を用いた肺癌の腫瘍遺伝子変異量予測モデルの開発

    Grant number：23K07103

    2023.4 - 2026.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    山崎 元彦, 石川 浩志, 大橋 瑠子, 若井 俊文, 奥田 修二郎, 島田 能史, 後藤 達哉, 土田 正則, 竹中 朋祐, 河野 幹寛

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • 血清中酸化ストレスマーカーによる間質性肺疾患合併肺癌術後急性増悪予測能の検討

    Grant number：22K08993

    2022.4 - 2026.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    小池 輝元, 後藤 達哉, 土田 正則

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    Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）

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