2025/01/05 更新

写真a

ゴトウ タツヤ
後藤 達哉
GOTO Tatsuya
所属
医歯学総合病院 呼吸器外科 助教
職名
助教
外部リンク

学位

  • 博士(医学) ( 2001年   新潟大学 )

経歴

  • 新潟大学   医歯学総合病院 呼吸器外科   助教

    2020年4月 - 現在

 

論文

  • Surgical Treatment Outcomes of Patients with Non-Small Cell Lung Cancer and Lymph Node Metastases. 国際誌

    Yuki Shimizu, Terumoto Koike, Toshiki Hasebe, Masaya Nakamura, Tatsuya Goto, Shin-Ichi Toyabe, Masanori Tsuchida

    Cancers   15 ( 12 )   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This study aimed to investigate the appropriate subgroups for surgery and adjuvant chemotherapy in patients with non-small-cell lung cancer (NSCLC) and nodal metastases. We retrospectively reviewed 210 patients with NSCLC and nodal metastases who underwent surgery and examined the risk factors for poor overall survival (OS) and recurrence-free probability (RFP) using multivariate Cox proportional hazards analysis. Pathological N1 and N2 were observed in 114 (52.4%) and 96 (47.6%) patients, respectively. A single positive node was identified in 102 patients (48.6%), and multiple nodes were identified in 108 (51.4%). Multivariate analysis revealed that vital capacity < 80% (hazard ratio [HR]: 2.678, 95% confidence interval [CI]: 1.483-4.837), radiological usual interstitial pneumonia pattern (HR: 2.321, 95% CI: 1.506-3.576), tumor size > 4.0 cm (HR: 1.534, 95% CI: 1.035-2.133), and multiple-node metastases (HR: 2.283, 95% CI: 1.517-3.955) were significant independent risk factors for poor OS. Tumor size > 4.0 cm (HR: 1.780, 95% CI: 1.237-2.562), lymphatic permeation (HR: 1.525, 95% CI: 1.053-2.207), and multiple lymph node metastases (HR: 2.858, 95% CI: 1.933-4.226) were significant independent risk factors for recurrence. In patients with squamous cell carcinoma (n = 93), there were no significant differences in OS or RFP between those who received platinum-based adjuvant chemotherapy (n = 25) and those who did not (n = 68), at p = 0.690 and p = 0.292, respectively. Multiple-node metastases were independent predictors of poor OS and recurrence. Patients with NSCLC and single-node metastases should be considered for surgery despite N2 disease. Additional treatment with platinum-based adjuvant chemotherapy may be expected, especially in patients with squamous cell carcinoma.

    DOI: 10.3390/cancers15123098

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  • [Analysis of Surgical Margin Recurrence Following Segmentectomy for Early-stage Non-small Cell Lung Cancer].

    Tatsuya Goto, Mika Miyajima, Masaya Nakamura, Yuki Shimizu, Terumoto Koike, Masanori Tsuchida

    Kyobu geka. The Japanese journal of thoracic surgery   76 ( 1 )   84 - 89   2023年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Surgical margin recurrence following segmentectomy is a critical issue because it may have been avoided by lobectomy. METHODS: Between January 2000 and December 2018, we retrospectively investigated 199 patients who underwent segmentectomy for c-StageⅠ non-small cell lung cancer at our hospital. RESULTS: Recurrence occurred in 20 cases, of which 3 cases had surgical margin recurrence. In our previous study, the recurrence risk factor after segmentectomy was radiologic solid tumor size( cut-off value 1.5 cm). Of the 130 patients in the low-risk group with radiologic solid tumor size of less than 1.5 cm, five had any recurrence, three of which had surgical margin recurrence. In the high-risk group with radiologic solid tumor size of 1.5 cm or more, no surgical margin recurrence was observed. Three cases of surgical margin recurrence were accompanied by lepidic components, and the tumors were difficult to identify intraoperatively and were located close to adjacent areas. CONCLUSION: Surgical margin recurrence may be avoided by carefully considering the segments to be resected and improving the method for identifying the intersegmental plane.

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  • Maximum Standardized Uptake Value on Positron Emission Tomography is Associated With More Advanced Disease and High-risk Features in Lung Adenocarcinoma. 国際誌

    Terumoto Koike, Noriaki Sato, Yuta Hosoda, Masayuki Tazawa, Tatsuya Goto, Seijiro Sato, Motohiko Yamazaki, Shin-Ichi Toyabe, Masanori Tsuchida

    Seminars in thoracic and cardiovascular surgery   34 ( 3 )   1051 - 1060   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) has been widely used for preoperative staging of lung adenocarcinomas. The aim of this study was to determine whether a high maximum standardized uptake value (SUVmax) could correlate with pathological characteristics in those patients. We retrospectively reviewed patients with clinical stage 0-IA lung adenocarcinoma who underwent preoperative 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography followed by curative anatomical resection. To identify more advanced disease and high-risk features, representing visceral pleural involvement, pulmonary metastasis, lymph node involvement, and lymphovascular involvement in resected surgical specimens, univariate and multivariate logistic regression analyses were performed. The optimal cutoff point for the SUVmax was determined by receiver operating characteristic analysis. In 2 groups divided according to the cutoff point, the disease-free survivals were calculated and compared using the Kaplan-Meier method and the log-rank test. More advanced disease and high-risk features were identified in 55 (18.9%) of the 291 patients. SUVmax was significantly correlated with more advanced disease and high-risk features, as did the consolidation/tumor ratio on computed tomography. Only 2 (1.2%) of the 169 patients with a SUVmax <3.20 showed more advanced disease and high-risk features, compared with 43.4% of patients with a SUVmax ≥3.20. The disease-free survival was significantly higher in patients with a SUVmax <3.20 than in those with a SUVmax ≥3.20 (P = 0.002). A high SUVmax correlates with more advanced disease and high-risk features in patients with clinical stage 0-IA lung adenocarcinoma. The SUVmax should be considered when deciding treatment strategy in early-stage lung adenocarcinoma.

    DOI: 10.1053/j.semtcvs.2021.07.019

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  • Surgical outcomes of ipsilateral metachronous second primary lung cancer

    Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Takahisa Koizumi, Takehiro Watanabe, Hirohiko Shinohara, Yasushi Yamato, Masanori Tsuchida

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   32 ( 6 )   896 - 903   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    OBJECTIVES: The optimal surgical approach for metachronous second primary lung cancer (MSPLC), especially ipsilateral MSPLC, remains unclear. This study aimed to review postoperative complications and examine surgical outcomes based on the extent of resection after surgery for ipsilateral MSPLC.METHODS: Clinical data from 61 consecutive patients who underwent pulmonary resection for ipsilateral MSPLC according to the Martini-Melamed criteria between January 2005 and December 2017 in 3 institutes were retrospectively reviewed.RESULTS: Postoperative complications were identified in 12 patients (19.7%). Regarding the combination of initial and second surgery, intraoperative bleeding was significantly greater in patients with anatomic-anatomic resection than in others (P < 0.001). Operation time was significantly longer in patients with anatomic-anatomic resection than in others (P <0.001). However, postoperative complications showed no significant differences based on the combination of surgeries. Five-year overall survival rates in patients with anatomic resection and wedge resection after second surgery were 75.8% and 75.8%, respectively (P= 0.738), and 5-year recurrence-free survival rates were 54.2% and 67.6%, respectively (P = 0.368). Cox multivariate analysis identified ever-smoker status (P = 0.029), poor performance status (P = 0.011) and tumour size >20 mm (P = 0.001) as independent predictors of poor overall survival, while ever-smoker status (P = 0.040) and tumour size >20 mm (P = 0.007) were considered independent predictors of poor recurrence-free survival.CONCLUSIONS: Regarding postoperative and long-term outcomes for patients with ipsilateral MSPLC, surgical intervention is safe and offers good long-term survival. Wedge resection is an acceptable provided tumours <= 2 cm and ground-glass opacity-predominant as a second surgery for early-stage ipsilateral MSPLC.

    DOI: 10.1093/icvts/ivab025

    Web of Science

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  • Surgical outcomes of ipsilateral metachronous second primary lung cancer. 国際誌

    Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Takahisa Koizumi, Takehiro Watanabe, Hirohiko Shinohara, Yasushi Yamato, Masanori Tsuchida

    Interactive cardiovascular and thoracic surgery   32 ( 6 )   896 - 903   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: The optimal surgical approach for metachronous second primary lung cancer (MSPLC), especially ipsilateral MSPLC, remains unclear. This study aimed to review postoperative complications and examine surgical outcomes based on the extent of resection after surgery for ipsilateral MSPLC. METHODS: Clinical data from 61 consecutive patients who underwent pulmonary resection for ipsilateral MSPLC according to the Martini-Melamed criteria between January 2005 and December 2017 in 3 institutes were retrospectively reviewed. RESULTS: Postoperative complications were identified in 12 patients (19.7%). Regarding the combination of initial and second surgery, intraoperative bleeding was significantly greater in patients with anatomic-anatomic resection than in others (P < 0.001). Operation time was significantly longer in patients with anatomic-anatomic resection than in others (P < 0.001). However, postoperative complications showed no significant differences based on the combination of surgeries. Five-year overall survival rates in patients with anatomic resection and wedge resection after second surgery were 75.8% and 75.8%, respectively (P = 0.738), and 5-year recurrence-free survival rates were 54.2% and 67.6%, respectively (P = 0.368). Cox multivariate analysis identified ever-smoker status (P = 0.029), poor performance status (P = 0.011) and tumour size >20 mm (P = 0.001) as independent predictors of poor overall survival, while ever-smoker status (P = 0.040) and tumour size >20 mm (P = 0.007) were considered independent predictors of poor recurrence-free survival. CONCLUSIONS: Regarding postoperative and long-term outcomes for patients with ipsilateral MSPLC, surgical intervention is safe and offers good long-term survival. Wedge resection is an acceptable provided tumours ≤2 cm and ground-glass opacity-predominant as a second surgery for early-stage ipsilateral MSPLC.

    DOI: 10.1093/icvts/ivab025

    PubMed

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▶ 全件表示

MISC

  • Radical segmentectomy as a potential alternative surgical treatment with curative intent in early-stage non-small cell lung cancer

    Terumoto Koike, Tatsuya Goto, Seijiro Sato, Masanori Tsuchida

    JOURNAL OF THORACIC DISEASE   12 ( 10 )   6115 - 6119   2020年10月

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    記述言語:英語   出版者・発行元:AME PUBL CO  

    DOI: 10.21037/jtd-20-1582

    Web of Science

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  • Repeated Lung Resection of Ipsilateral Lung Cancer That is Detected after Segmentectomy for Primary Lung Cancer

    Masanori Tsuchida, Tatsuya Goto, Akihiko Kitahara, Seijiro Sato, Terumoto Koike

    JOURNAL OF THORACIC ONCOLOGY   12 ( 1 )   S1399 - S1399   2017年1月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER SCIENCE INC  

    DOI: 10.1016/j.jtho.2016.11.2140

    Web of Science

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  • Comprehensive Genomic Alterations Identified by Next-Generation Sequencing of Lung Adenocarcinoma in Japanese Population

    Seijiro Sato, Masayuki Nagahashi, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Kazuki Takada, Tatsuro Okamoto, Keisuke Kodama, Hiroshi Izutsu, Mitsutaka Nakada, Yoshihiko Maehara, Toshifumi Wakai, Masanori Tsuchida

    JOURNAL OF THORACIC ONCOLOGY   12 ( 1 )   S531 - S532   2017年1月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER SCIENCE INC  

    Web of Science

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  • PS-019-3 Parapneumotic effusionに対する積極的胸腔鏡手術の有用性(PS ポスターセッション,第113回日本外科学会定期学術集会)

    青木 正, 後藤 達哉, 矢澤 正知

    日本外科学会雑誌   114 ( 2 )   544 - 544   2013年3月

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    記述言語:日本語   出版者・発行元:一般社団法人日本外科学会  

    CiNii Article

    CiNii Books

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共同研究・競争的資金等の研究

  • 放射線・病理画像テクスチャ解析を用いた肺癌の腫瘍遺伝子変異量予測モデルの開発

    研究課題/領域番号:23K07103

    2023年4月 - 2026年3月

    制度名:科学研究費助成事業

    研究種目:基盤研究(C)

    提供機関:日本学術振興会

    山崎 元彦, 石川 浩志, 大橋 瑠子, 若井 俊文, 奥田 修二郎, 島田 能史, 後藤 達哉, 土田 正則, 竹中 朋祐, 河野 幹寛

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    配分額:4680000円 ( 直接経費:3600000円 、 間接経費:1080000円 )

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  • 血清中酸化ストレスマーカーによる間質性肺疾患合併肺癌術後急性増悪予測能の検討

    研究課題/領域番号:22K08993

    2022年4月 - 2026年3月

    制度名:科学研究費助成事業

    研究種目:基盤研究(C)

    提供機関:日本学術振興会

    小池 輝元, 後藤 達哉, 土田 正則

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    配分額:4030000円 ( 直接経費:3100000円 、 間接経費:930000円 )

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