Updated on 2024/12/21

写真a

 
TSUBOGUCHI Shintaro
 
Organization
Brain Research Institute Assistant Professor
Title
Assistant Professor
External link

Degree

  • 博士(医学) ( 2021.3 )

Research Interests

  • ALS (Amyotrophic lateral sclerosis)

  • spreading of TDP-43, propagation of TDP-43

Research History (researchmap)

  • Brain Research Institute, Niigata University   Department of Neurology   Assistant Professor

    2022.4

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  • Niigata University Medical and Dental Hospital   Department of Neurology   Assistant Professor

    2021.4 - 2022.3

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Research History

  • Niigata University   Brain Research Institute   Assistant Professor

    2022.4

  • Niigata University   University Medical and Dental Hospital   Assistant Professor

    2021.4 - 2022.3

Education

  • Niigata University   Graduate School of Medicine and Dental Sciences

    2017.4 - 2021.3

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  • University of Fukui   School of Medical Sciences

    2006.4 - 2012.3

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  • 福井県立藤島高等学校

    2003.4 - 2006.3

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Papers

  • TDP-43 differentially propagates to induce antero- and retrograde degeneration in the corticospinal circuits in mouse focal ALS models Reviewed

    Shintaro Tsuboguchi, Yuka Nakamura, Tomohiko Ishihara, Taisuke Kato, Tokiharu Sato, Akihide Koyama, Hideki Mori, Yuka Koike, Osamu Onodera, Masaki Ueno

    Acta Neuropathologica   146 ( 4 )   611 - 629   2023.8

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1007/s00401-023-02615-8

    PubMed

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    Other Link： https://link.springer.com/article/10.1007/s00401-023-02615-8/fulltext.html

  • Case report: Progressive multifocal leukoencephalopathy cooccurring with neurosarcoidosis: early brain biopsy and appropriate therapy for PML resulted in a favorable prognosis Reviewed

    Qiannan Wang, Shintaro Tsuboguchi, Kouichirou Okamoto, Mari Tada, Akiyoshi Kakita, Kazuo Nakamichi, Makoto Oishi, Masato Kanazawa, Osamu Onodera

    Frontiers in Immunology   15   1447992   2024.10

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fimmu.2024.1447992

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  • A case of isolated dystextia due to subcortical infarction: a novel condition of digital device era Reviewed

    Masahiro Hatakeyama, Takeshi Kanayama, Saori Tokunaga, Toshiya Kizaki, Shintaro Tsuboguchi, Masato Kanazawa, Osamu Onodera

    BMC Neurology   24 ( 1 )   374   2024.10

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1186/s12883-024-03892-w

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    Other Link： https://link.springer.com/article/10.1186/s12883-024-03892-w/fulltext.html

  • A patient with neuronal intranuclear inclusion disease developed encephalitis‐like symptoms after cerebral angiography Reviewed

    Shin Koide, Shintaro Tsuboguchi, Shingo Koide, Itaru Ninomiya, Taiki Saito, Takanobu Ishiguro, Etsuji Saji, Yo Higuchi, Takeshi Ikeuchi, Makoto Oishi, Masato Kanazawa, Osamu Onodera

    Neurology and Clinical Neuroscience   2024.6

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Patients with neuronal intranuclear inclusion disease (NIID) can present with encephalitis‐like symptoms such as recurrent paroxysmal fever and unconsciousness. To date, no specific triggers for these symptoms have been reported. In our case, an 78‐year‐old woman became unconscious and developed fever after cerebral angiography. The patient had experienced four episodes of unconsciousness and fever in the past 7 years. Postangiography, she immediately became unconscious and developed fever. No vascular abnormalities were found and magnetic resonance imaging of the brain revealed expanding white matter lesions and hyperintense lesions along the corticomedullary junction. Genetic analysis revealed an abnormal GGC repeat expansion in NOTCH2NLC. Thus, we diagnosed the patient with NIID. We suggest that cerebral angiography is a possible trigger for encephalitis‐like symptoms in NIID.

    DOI： 10.1111/ncn3.12839

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  • A case report of reversible cerebral vasoconstriction syndrome with thunderclap headache significantly exacerbated in the supine position and alleviated in the standing position Reviewed International journal

    Genri Toyama, Shintaro Tsuboguchi, Kazuya Igarashi, Etsuji Saji, Takuya Konno, Osamu Onodera

    BMC neurology   23 ( 1 )   348   2023.10

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by sudden onset thunderclap headache and multiple segmental reversible cerebral vasoconstrictions that improve within 3 months. The postpartum period is a well-known precipitating factor for the onset of RCVS. Cerebral venous thrombosis (CVT) causes thunderclap headaches in the postpartum period. While headache in CVT is sometimes exacerbated in the supine position, the severity of the headache in RCVS is usually independent of body position. In this study, we report a case of RCVS with thunderclap headache exacerbated in the supine position, and headache attacks that resolved quickly in the standing position during the postpartum period. CASE PRESENTATION: A 33-year-old woman presented with a sudden increase in blood pressure and thunderclap headache on the fifth postpartum day (day 1: the first sick day). The headache was severe and pulsatile, with onset in the supine position in bed, and peaked at approximately 10 s. It was accompanied by nausea and chills but there were no scintillating scotomas or ophthalmic symptoms. The headache resolved in the standing or sitting position but was exacerbated and became unbearable within a few seconds when the patient was in the supine position. Therefore, she was unable to lie supine at night. Computed tomography angiography (CTA) of the head on day 2 and magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) on day 3 showed no abnormalities. However, considering the possibility of RCVS, verapamil was initiated on day 3. The headache resolved the following day. MRA of the head on day 10 revealed diffuse and segmental stenoses in the bilateral middle and posterior cerebral arteries and basilar artery. Therefore, the patient was diagnosed with RCVS. The headache gradually resolved and disappeared completely on day 42. Cerebral vasoconstriction was also improved on MRA on day 43. CONCLUSIONS: This postpartum RCVS case was notable for the exacerbation of headaches in the supine position. For the diagnosis of thunderclap headache in the postpartum period, RCVS should be considered in addition to CVT when the patient presents with a headache that is exacerbated in the supine position.

    DOI： 10.1186/s12883-023-03381-6

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  • Disseminated herpes zoster complicated by lumbosacral polyradiculoneuritis and fibular neuropathy: A case report Reviewed

    Kosei Nakamura, Shintaro Tsuboguchi, Itaru Ninomiya, Osamu Ansai, Masato Kanazawa, Osamu Onodera

    Rinsho Shinkeigaku   63 ( 6 )   359 - 362   2023.7

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    Authorship：Corresponding author   Publisher：Societas Neurologica Japonica  

    DOI： 10.5692/clinicalneurol.cn-001848

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  • Heterogenous Genetic, Clinical, and Imaging Features in Patients with Neuronal Intranuclear Inclusion Disease Carrying NOTCH2NLC Repeat Expansion Reviewed

    Yusran Ady Fitrah, Yo Higuchi, Norikazu Hara, Takayoshi Tokutake, Masato Kanazawa, Kazuhiro Sanpei, Tomone Taneda, Akihiko Nakajima, Shin Koide, Shintaro Tsuboguchi, Midori Watanabe, Junki Fukumoto, Shoichiro Ando, Tomoe Sato, Yohei Iwafuchi, Aki Sato, Hideki Hayashi, Takanobu Ishiguro, Hayato Takeda, Toshiaki Takahashi, Nobuyoshi Fukuhara, Kensaku Kasuga, Akinori Miyashita, Osamu Onodera, Takeshi Ikeuchi

    Brain Sciences   13 ( 6 )   955   2023.6

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    Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder that is caused by the abnormal expansion of non-coding trinucleotide GGC repeats in NOTCH2NLC. NIID is clinically characterized by a broad spectrum of clinical presentations. To date, the relationship between expanded repeat lengths and clinical phenotype in patients with NIID remains unclear. Thus, we aimed to clarify the genetic and clinical spectrum and their association in patients with NIID. For this purpose, we genetically analyzed Japanese patients with adult-onset NIID with characteristic clinical and neuroimaging findings. Trinucleotide repeat expansions of NOTCH2NLC were examined by repeat-primed and amplicon-length PCR. In addition, long-read sequencing was performed to determine repeat size and sequence. The expanded GGC repeats ranging from 94 to 361 in NOTCH2NLC were found in all 15 patients. Two patients carried biallelic repeat expansions. There were marked heterogenous clinical and imaging features in NIID patients. Patients presenting with cerebellar ataxia or urinary dysfunction had a significantly larger GGC repeat size than those without. This significant association disappeared when these parameters were compared with the total trinucleotide repeat number. ARWMC score was significantly higher in patients who had a non-glycine-type trinucleotide interruption within expanded poly-glycine motifs than in those with a pure poly-glycine expansion. These results suggested that the repeat length and sequence in NOTCH2NLC may partly modify some clinical and imaging features of NIID.

    DOI： 10.3390/brainsci13060955

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  • Dysarthria-facial paresis syndrome due to long insular artery infarction Reviewed

    Ryutaro Hanyu, Shintaro Tsuboguchi, Itaru Ninomiya, Takanobu Ishiguro, Takuya Konno, Masato Kanazawa, Osamu Onodera

    Journal of the Neurological Sciences   442   120456   2022.11

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.jns.2022.120456

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  • Patients with heterozygous HTRA1-related cerebral small vessel disease misdiagnosed with other diseases: Two case reports Reviewed

    Sho Kitahara, Shintaro Tsuboguchi, Masahiro Uemura, Hiroaki Nozaki, Masato Kanazawa, Osamu Onodera

    Clinical Neurology and Neurosurgery   223   107502   2022.10

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.clineuro.2022.107502

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  • Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex Reviewed

    Yuka Koike, Akihiro Sugai, Norikazu Hara, Junko Ito, Akio Yokoseki, Tomohiko Ishihara, Takuma Yamagishi, Shintaro Tsuboguchi, Mari Tada, Takeshi Ikeuchi, Akiyoshi Kakita, Osamu Onodera

    Communications Biology   4 ( 1 )   1107   2021.9

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    In amyotrophic lateral sclerosis (ALS), TAR DNA-binding protein 43 (TDP-43), which is encoded by TARDBP, forms aggregates in the motor cortex. This aggregate formation may be triggered by an increase in the TDP-43 level with aging. However, the amount of TDP-43 is autoregulated by alternative splicing of the TARDBP 3′UTR, and how this autoregulation is affected by aging remains to be elucidated. We found that DNA demethylation in the autoregulatory region in the TARDBP 3′UTR reduced alternative splicing and increased TARDBP mRNA expression. Furthermore, in the human motor cortex, we found that this region was demethylated with aging, resulting in increased expression of TARDBP mRNA. The acceleration of DNA demethylation in the motor cortex was associated with the age of ALS onset. In summary, the dysregulation of TDP-43 autoregulation by age-related DNA demethylation in the motor cortex may explain the contribution of aging and motor system selectivity in ALS.

    DOI： 10.1038/s42003-021-02621-0

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    Other Link： https://www.nature.com/articles/s42003-021-02621-0

  • Rare Brain Metastasis From a Pancreatobiliary Subtype of Intraductal Papillary Mucinous Neoplasm Reviewed

    Yoshihisa Arao, Kenya Kamimura, Masatoshi Ikemi, Kazunao Hayashi, Masayuki Takaki, Shunsaku Takahashi, Satoshi Seino, Hiroyuki Abe, Shintaro Tsuboguchi, Yutaka Otsu, Kazuhiro Sanpei, Junji Kohisa, Shuhei Kondo, Yusuke Tani, Junko Ito, Yasuko Toyoshima, Akiyoshi Kakita, Yoichi Ajioka, Shuji Terai

    Pancreas   49 ( 1 )   e8 - e11   2020.1

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    Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

    DOI： 10.1097/mpa.0000000000001450

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  • Herpes simplex encephalitis presenting as stroke-like symptoms with atypical MRI findings and lacking cerebrospinal fluid pleocytosis Reviewed

    Shintaro Tsuboguchi, Takahiro Wakasugi, Yoshitaka Umeda, Maiko Umeda, Mutsuo Oyake, Nobuya Fujita

    Rinsho Shinkeigaku   57 ( 7 )   387 - 390   2017.7

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    Authorship：Lead author   Publisher：Societas Neurologica Japonica  

    DOI： 10.5692/clinicalneurol.cn-001033

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  • A case of slowly progressive anti-Yo-associated paraneoplastic cerebellar degeneration successfully treated with antitumor and immunotherapy Reviewed

    Shintaro Tsuboguchi, Ryuji Yajima, You Higuchi, Masanori Ishikawa, Izumi Kawachi, Yu Koyama, Masatoyo Nishizawa

    Rinsho Shinkeigaku   56 ( 7 )   477 - 480   2016.7

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    Authorship：Lead author   Publisher：Societas Neurologica Japonica  

    DOI： 10.5692/clinicalneurol.cn-000872

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MISC

  • ALSにおける異常タンパク質の伝播 TDP-43による運動神経回路内の病態の進行

    Shintaro Tsuboguchi, Osamu Onodera, Masaki Ueno

    Farumashia   60 ( 5 )   393 - 397   2024.5

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    Authorship：Lead author  

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  • 左大脳皮質下梗塞により純粋dystypia,純粋dystextiaを呈した1例

    畠山公大, 金山武史, 徳永沙緒里, 木崎利哉, 坪口晋太朗, 金澤雅人, 小野寺理

    高次脳機能研究   44 ( 1 )   2024

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  • 下垂体炎に伴う中枢性尿崩症により生じた二次性後天性全身性無汗症の1例

    大橋凌也, 林良太, 鈴木紗也佳, 筒井由夏, 加勢夕季乃, 富井光一, 阿部理一郎, 坪口晋太朗, 北澤勝, 曽根博仁

    日本皮膚科学会雑誌   134 ( 5 )   2024

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  • TDP-43変異型により異なる病態進展特性の解析

    森秀樹, 坪口晋太朗, 佐藤時春, 中村由香, 加藤泰介, 須貝章弘, 小野寺理, 上野将紀

    Dementia Japan   37 ( 4 )   2023

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  • Two cases of motor nerve palsy associated with disseminated herpes zoster

    SUZUKI Sayaka, ANSAI Osamu, TAKEI Izumi, KIMURA Kiyoto, HASEGAWA Akito, TSUCHIDA Yuko, ABE Riichiro, NAKAMURA Kosei, HONGO Shoko, TSUBOGUCHI Shintaro, SAJI Koji, MURATA Masaki

    日本皮膚科学会雑誌   133 ( 2 )   2023

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  • Long insular artery梗塞の臨床的検討と冠状断画像の有用性

    羽入龍太郎, 坪口晋太朗, 二宮格, 石黒敬信, 今野卓哉, 金澤雅人, 小野寺理

    日本神経学会学術大会プログラム・抄録集   64th   2023

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  • 初期にCastleman病が疑われ特徴的な神経伝導検査所見を呈した61歳男性例

    畠山祐樹, 坪口晋太朗, 石黒敬信, 佐治越爾, 細島康宏, 片桐隆幸, 金澤雅人, 小野寺理

    臨床神経学(Web)   63 ( 4 )   2023

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  • 脳血管造影検査後の発熱・意識障害で診断された神経核内封入体病(NIID)の一例

    小出伸, 坪口晋太朗, 二宮格, 齋藤太希, 石黒敬信, 佐治越爾, 鈴木倫明, 金澤雅人, 小野寺理

    臨床神経学(Web)   63 ( 3 )   2023

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  • TDP-43 differentially propagates to induce degeneration in the motor circuit

    坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 佐藤時春, 小山哲秀, 森秀樹, 小池佑佳, 小野寺理, 小野寺理, 上野将紀

    Dementia Japan   37 ( 4 )   2023

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  • 発作性の神経症状を繰り返し,多発する微小出血像を認めた硬膜移植歴を有する39歳男性例

    畠山祐樹, 坪口晋太朗, 石黒敬信, 佐治越爾, 畠山公大, 島田斉, 金澤雅人, 小野寺理

    臨床神経学(Web)   63 ( 9 )   2023

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  • 進行性多巣性白質脳症に神経サルコイドーシスを合併した65歳女性

    王倩楠, 坪口晋太朗, 木崎利哉, 小出伸, 山岸拓磨, 佐治越爾, 石黒敬信, 金澤雅人, 小野寺理

    神経治療学(Web)   40 ( 6 )   2023

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  • 進行性の認知機能低下を認めたヘテロ接合性HTRA1関連脳小血管病の2症例

    北原匠, 上村昌寛, 坪口晋太朗, 野崎洋明, 金澤雅人, 小野寺理

    Dementia Japan   36 ( 4 )   2022

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  • 多発性硬化症と誤診されたヘテロ接合性HTRA-1関連脳小血管病の1例

    北原匠, 坪口晋太朗, 上村昌寛, 野崎洋明, 今野卓哉, 金澤雅人, 小野寺理

    臨床神経学(Web)   62 ( 8 )   2022

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  • 高齢者の神経疾患における遺伝子診断

    Shintaro Tsuboguchi, Tomohiko Ishihara, Osamu Onodera

    Geriatric Medicine   59 ( 12 )   1189 - 1192   2021.12

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    Authorship：Lead author  

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  • Development of Mouse ALS Model to Detect TDP-43 Inclusions and Spreading

    Shintaro Tsuboguchi

    新潟医学会雑誌   135 ( 1/3 )   2021.3

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    Authorship：Lead author  

    J-GLOBAL

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  • 加齢と関連したDNA脱メチル化がTDP-43量の自己調節機構を障害する

    小池佑佳, 須貝章弘, 原範和, 伊藤絢子, 横関明男, 石原智彦, 山岸拓磨, 坪口晋太朗, 他田真理, 池内健, 柿田明美, 小野寺理

    Dementia Japan   35 ( 4 )   2021

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  • Spreading of TDP-43 via direct corticospinal connections in mouse models

    TSUBOGUCHI Shintaro, NAKAMURA Yuka, ISHIHARA Tomohiko, KATO Taisuke, KOYAMA Akihide, SATO Tokiharu, YOSHIDA Yutaka, UENO Masaki, ONODERA Osamu

    日本神経学会学術大会プログラム・抄録集   61st   2020

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  • Intracortical and corticospinal spreading of TDP-43 in mouse FTLD/ALS models

    坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 小山哲秀, 佐藤時春, 吉田富, 上野将紀, 小野寺理, 小野寺理

    Dementia Japan   34 ( 4 )   2020

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  • Molecular Pathogenesis of Amyotrophic Lateral Sclerosis

    Shintaro Tsuboguchi, Tomohiko Ishihara, Akihiro Sugai, Akio Yokoseki, Osamu Onodera

    Brain and nerve   71 ( 11 )   1183 - 1189   2019.11

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    The molecular pathogenesis of amyotrophic lateral sclerosis (ALS) has been studied through analysis of the function of the protein produced by the causative genes of familial ALS. The products of these genes are classified as RNA binding proteins, or proteins related to proteolytic systems. However, most case of familial ALS, and sporadic ALS show TAR DNA binding protein-43 (TDP-43) immune-positive cytoplasmic inclusions. Therefore, the molecular mechanism of formation of TDP-43 inclusions and dysfunction caused by TDP-43 inclusions has been studied. As for the mechanism of inclusion formation, non-membrane organelle formation by liquid-liquid phase separation (LLPS) is important. The ubiquitin-proteasome and autophagy systems are important for the degradation of these inclusions. Several genes associated with these systems have been identified as causative genes for ALS. The formation of cytoplasmic inclusions results in the loss of TDP-43 from the nucleus, resulting in abnormalities in RNA metabolism, through the alteration of spliceosomes and Gemini of coiled bodies. Furthermore, in ALS, the regulation of TDP-43 mRNA/protein expression levels has failed. Failure of the autoregulation system facilitates TDP-43 inclusion formation. Development of treatments for ALS based on these elucidated molecular mechanisms is desirable.

    DOI： 10.11477/mf.1416201428

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    Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J04871&link_issn=&doc_id=20191114320010&doc_link_id=40022086926&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F40022086926&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

  • Friedreich 失調症と鉄代謝

    Shintaro Tsuboguchi, Tomohiko Ishihara, Osamu Onodera

    Clinical Neuroscience   37 ( 3 )   308 - 310   2019.3

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  • タウオパチーでは,正常圧水頭症の画像所見を呈することがある

    安藤昭一朗, 坪口晋太朗, 山田友美, 梅田能生, 梅田麻衣子, 小宅睦郎, 藤田信也

    日本神経学会学術大会プログラム・抄録集   59th   2018

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  • 痙攣重積で発症し,静脈洞血栓症を合併したと考えられた髄液漏出症の79歳女性例

    坪口晋太朗, 樋口陽, 三瓶一弘

    臨床神経学(Web)   57 ( 4 )   2017

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  • 頭部MRI磁化率強調像が診断に有用であった脳アミロイドアンギオパチー関連炎症の1例

    河辺啓太, 坪口晋太朗, 若杉尚宏, 梅田能生, 梅田麻衣子, 小宅睦郎, 藤田信也

    長岡赤十字病院医学雑誌   29 ( 1 )   2016

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  • 抗Lrp4抗体単独陽性重症筋無力症の69歳男性例

    若杉尚宏, 坪口晋太朗, 梅田能生, 梅田麻衣子, 小宅睦郎, 藤田信也

    臨床神経学(Web)   56 ( 3 )   2016

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  • 画像上,正常圧水頭症が鑑別となった進行性核上性麻痺の82歳男性例

    坪口晋太朗, 若杉尚宏, 梅田能生, 梅田麻衣子, 小宅睦郎, 藤田信也

    臨床神経学(Web)   56 ( 7 )   2016

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  • 多数の結核腫を形成し,治療に難渋した結核性髄膜脳炎の22歳男性例

    若杉尚宏, 坪口晋太朗, 梅田能生, 梅田麻衣子, 小宅睦郎, 関根有美, 西堀武明, 藤田信也

    臨床神経学(Web)   56 ( 9 )   2016

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  • 多発する大脳白質病変を合併したリウマチ性軟膜炎の61歳男性例

    坪口晋太朗, 若杉尚宏, 梅田能生, 梅田麻衣子, 小宅睦郎, 藤田信也

    臨床神経学(Web)   56 ( 2 )   2016

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  • 3か月の経過で両側性の視神経障害を来たした63歳男性

    畠野雄也, 石原智彦, 坪口晋太朗, 矢野隆二, 植木智志, 畑瀬哲尚, 下畑享良, 西澤正豊

    臨床神経学(Web)   56 ( 2 )   2016

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  • 緩徐に進行する小脳症状を呈した54歳女性例

    坪口晋太朗, 矢島隆二, 樋口陽, 石川正典, 河内泉, 小山諭, 西澤正豊

    臨床神経学(Web)   55 ( 1 )   2015

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  • 日本語とポルトガル語で語義失語を認めた日系ブラジル人の71歳男性例

    坪口晋太朗, 徳武孝允, 関根有美, 大槻美佳, 下畑享良, 西澤正豊

    臨床神経学(Web)   55 ( 8 )   2015

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Presentations

  • TDP-43-induced antero- and retrograde degeneration and propagation in the corticospinal circuits in mouse ALS models.

    Shintaro Tsuboguchi, Yuka Nakamura, Tomohiko Ishihara, Taisuke Kato, Tokiharu Sato, Akihide Koyama, Hideki Mori, Yuka Koike, Osamu Onodera, Masaki Ueno

    2024.7 

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    Language：English   Presentation type：Symposium, workshop panel (nominated)  

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Awards

  • Niigata University President's Award

    2024.11   Niigata University  

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  • Niigata University Outstanding Paper Award

    2024.9   Niigata University   TDP-43 differentially propagates to induce antero-and retrograde degeneration in the corticospinal circuits in mouse focal ALS models

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Research Projects

  • ALS系統変性の時空間的進展：臨床と病理の相関から探求する病態機序

    Grant number：23K06961

    2023.4 - 2026.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    清水 宏, 坪口 晋太朗, 岩崎 靖

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • TDP-43の伝播仮説の包括的検証ー上位運動神経から筋肉までの順行・逆行経路ー

    Grant number：22K15637

    2022.4 - 2025.3

    System name：科学研究費助成事業

    Research category：若手研究

    Awarding organization：日本学術振興会

    坪口 晋太朗

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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