Updated on 2024/03/29

写真a

 
Bamba Yuuki
 
Organization
University Medical and Dental Hospital Advanced Disaster Medical and Emergency Critical Care Center Assistant Professor
Title
Assistant Professor
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Degree

  • 博士(医学) ( 2019.3 )

Research Interests

  • Infectious Diseases

  • Pulmonary medicine

Research Areas

  • Life Science / Respiratory medicine  / Pulmonary Medicine

  • Life Science / Infectious disease medicine  / Infectious Diseases

Research History (researchmap)

  • Niigata University   Medical and Dental Hospital Advanced Disaster Medical and Emergency Critical Care Center   Assistant Professor

    2021.4

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    Country:Japan

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Research History

  • Niigata University   Advanced Disaster Medical and Emergency Critical Care Center, University Medical and Dental Hospital   Assistant Professor

    2021.4

Education

  • Niigata University   Graduate School of Medical and Dental Sciences   Course of Biological Functions and Medical Control

    2016.4 - 2019.3

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    Country: Japan

    Notes: Pulmonary Medicine

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  • Niigata University   Faculty of Medicine   School of Medicine

    2007.4 - 2013.3

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    Country: Japan

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Professional Memberships

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Papers

  • Dynamics of iron metabolism in patients with bloodstream infections: a time-course clinical study

    Hiroshi Moro, Yuuki Bamba, Kei Nagano, Mariko Hakamata, Hideyuki Ogata, Satoshi Shibata, Hiromi Cho, Nobumasa Aoki, Mizuho Sato, Yasuyoshi Ohshima, Satoshi Watanabe, Toshiyuki Koya, Toshinori Takada, Toshiaki Kikuchi

    Scientific Reports   13 ( 1 )   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    The close relationship between infectious diseases and iron metabolism is well known, but a more detailed understanding based on current knowledge may provide new insights into the diagnosis and treatment of infectious diseases, considering the growing threat of antibiotic-resistant bacteria. This study investigated adult patients with bloodstream infections, temporal changes, and relationships between blood levels of iron and related markers, including hepcidin and lipocalin-2 (LCN2). We included 144 samples from 48 patients (mean age 72 years, 50% male), with 30 diagnosed with sepsis. During the acute phase of infection, blood levels of hepcidin and LCN2 increased rapidly, whereas iron levels decreased, with values in 95.8% of cases below the normal range (40–188 μg/dL). Later, hepcidin and LCN2 decreased significantly during the recovery phase, and the decreased iron concentrations were restored. In the case of persistent inflammation, iron remained decreased. Acute LCN2 levels were significantly higher in patients with sepsis (p < 0.01). Hypoferremia induced by increased hepcidin would reduce iron in the environment of extracellular pathogens, and the increased LCN2 would inhibit siderophores, resulting in the prevention of the pathogen’s iron acquisition in each manner during the acute phase of bloodstream infection.

    DOI: 10.1038/s41598-023-46383-7

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    Other Link: https://www.nature.com/articles/s41598-023-46383-7

  • Factors associated with cytomegalovirus antigenemia in patients with rheumatic disease: A retrospective study.

    Ogata H, Aoki N, Nagano K, Hakamata M, Bamba Y, Shibata S, Koizumi T, Ohshima Y, Watanabe S, Moro H, Koya T, Kikuchi T

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2022.7

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    DOI: 10.1016/j.jiac.2022.07.004

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  • Efficacy of the new β-D-glucan measurement kit for diagnosing invasive fungal infections, as compared with that of four conventional kits

    Yuuki Bamba, Kei Nagano, Hiroshi Moro, Hideyuki Ogata, Mariko Hakamata, Satoshi Shibata, Takeshi Koizumi, Nobumasa Aoki, Yasuyoshi Ohshima, Satoshi Watanabe, Takeshi Nakamura, Sugako Kobayashi, Yoshiki Hoshiyama, Toshiyuki Koya, Toshinori Takada, Toshiaki Kikuchi

    PLOS ONE   2021.8

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    DOI: 10.1371/journal.pone.0255172

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  • An outbreak of serotype 19A pneumococcal pneumonia in a relief facility in Japan.

    Nagano K, Kawasaki S, Moro H, Chang B, Bamba Y, Yamamoto A, Morita M, Ohnishi M, Shibata S, Koizumi T, Aoki N, Honma Y, Abe T, Koya T, Aoki N, Kikuchi T

    Infection control and hospital epidemiology   2021.7

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    DOI: 10.1017/ice.2021.328

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  • 深在性真菌症診断における国内3種の(1→3)β-D-グルカン測定試薬の比較

    番場 祐基, 茂呂 寛, 永野 啓, 袴田 真理子, 島津 翔, 尾方 英至, 小泉 健, 張 仁美, 青木 信将, 林 正周, 佐藤 瑞穂, 坂上 亜希子, 小屋 俊之, 菊地 利明

    感染症学雑誌   93 ( 4 )   500 - 506   2019.7

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    Language:Japanese   Publisher:(一社)日本感染症学会  

    [目的]国内3種の(1→3)-β-D-グルカン(以下β-D-グルカン)測定試薬における測定結果と患者の臨床背景を比較し,深在性真菌症の診断における有用性および試薬間での測定結果の乖離,偽陽性の要因について評価する.[方法]新潟大学医歯学総合病院において2017年8月から2017年11月にかけてβ-D-グルカン検査が提出された患者を対象とし,測定残余血漿を用いて以下の3試薬について測定した.(1)ファンギテックGテストMKII「ニッスイ」(以下MKII法),(2)ファンギテックGテストES「ニッスイ」(以下ES法),(3)β-グルカンテストワコー(以下ワコー法).[成績]171患者,245検体が対象となった.深在性真菌症患者は疑診を含め7例であった.β-D-グルカン測定値は,同一検体間の比較でMKII法が最も高く,次いでES法,ワコー法の順であったが,互いに有意に相関していた.感度,特異度,陽性的中率,陰性的中率などの診断特性は各試薬によって異なっていた.MKII法で偽陽性を比較的多く認めたものの,深在性真菌症(疑診含む)診断におけるROC曲線下面積には有意差はなかった.いずれかの試薬による偽陽性を呈した14例について,階層型クラスター分析を用いて分類したところ,偽陽性のパターンに一定の傾向が認められた.[結論]各測定試薬によるβ-D-グルカン測定の結果は概ね相関しているが,測定値は大きく異なっており,異なる試薬同士の比較は困難である.深在性真菌症診断における差は小さいが,それぞれの試薬の診断特性を理解し使用するべきである.また試薬によって偽陽性の原因が異なる可能性が示唆された.(著者抄録)

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00276&link_issn=&doc_id=20190821320003&doc_link_id=10.11150%2Fkansenshogakuzasshi.93.500&url=https%3A%2F%2Fdoi.org%2F10.11150%2Fkansenshogakuzasshi.93.500&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • Multiplex cytokine analysis in Mycobacterium avium complex lung disease: relationship between CXCL10 and poor prognostic factors. International journal

    Bamba Y, Moro H, Aoki N, Koizumi T, Ohshima Y, Watanabe S, Sakagami T, Koya T, Takada T, Kikuchi T

    BMC infectious diseases   19 ( 1 )   263 - 263   2019.3

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    BACKGROUND: Mycobacterium avium complex lung disease (MAC-LD) can deteriorate rapidly to become fatal. Reported poor prognostic factors include radiographic findings, undernutrition, anemia and high inflammation test values. However, the association of these prognostic factors with the pathophysiology of the disease remains unknown. We aimed to clarify the pathophysiology of MAC-LD and develop a new biomarker that reflects the immune response to the disease. METHODS: We performed the cytokine panel analyses of serum from patients with MAC-LD and compared each cytokine level with clinically negative prognostic factors (radiographic disease type, body mass index, albumin, C-reactive protein and hemoglobin) and high-resolution CT scores. RESULTS: We analyzed 27 patients with MAC-LD, 6 with the fibrocavitary form and 21 with the nodular bronchiectatic form on high-resolution CT. Serum CXC motif ligand 10 (CXCL10) concentration was significantly elevated in patients with the fibrocavitary form (p = 0.008). CXCL10 levels correlated with body mass index (r = - 0.60, p = 0.0008), serum albumin concentration (r = - 0.45, p = 0.016) and high-resolution CT scores (r = 0.61, p = 0.0006). Among 14 patients initially untreated, antibiotic therapy was initiated for five during the study period. CXCL10 concentration was significantly higher in these patients (p = 0.046), and receiver operating characteristic analysis for CXCL10 concentration on treatment initiation produced an area under the curve of 0.844, with a sensitivity of 100%, specificity of 66.7%, and cut-off value of 366.5 pg/mL. CONCLUSION: We revealed cytokine profiles in patients with MAC-LD. Serum CXCL10 levels probably reflect the severity of MAC-LD. Our findings suggest that CXCL10 concentration may be a promising biomarker for managing treatment for patients with MAC disease of the lung.

    DOI: 10.1186/s12879-019-3888-4

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  • 636. The Hepcidin-25 and Iron Kinetics During the Acute Phase of Systemic Infection.

    Moro H, Bamba Y, Nagano K, Koizumi T, Aoki N, Ohshima Y, Watanabe S, Koya T, Takada T, Kikuchi T

    Open Forum Infectious Diseases   2018.11

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    DOI: 10.1093/ofid/ofy210.643

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  • Increased presepsin levels are associated with the severity of fungal bloodstream infections International journal

    Yuuki Bamba, Alix Therese Coste, Hiroshi Moro, Nobumasa Aoki, Takeshi Koizumi, Yasuyoshi Ohshima, Satoshi Watanabe, Takuro Sakagami, Toshiyuki Koya, Toshinori Takada, Toshiaki Kikuchi

    PLOS ONE   13 ( 10 )   e0206089   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science ({PLoS})  

    BACKGROUND: Presepsin is a widely recognized biomarker for sepsis. However, little is known about the usefulness of presepsin in invasive fungal infection. The aim of this study was to determine the plasma levels of presepsin in fungal bloodstream infections and to investigate whether it reflects the disease severity, similar to its utility in bacterial infections. METHODS: We prospectively measured presepsin in plasma samples from participants with fungemia from April 2016 to December 2017. The associations of C-reactive protein, procalcitonin, and presepsin concentrations with the severity of fungemia were statistically analyzed. In vitro assay was performed by incubating Escherichia coli, Candida albicans, and lipopolysaccharide to whole blood cells collected from healthy subjects; after 3 h, the presepsin concentration was measured in the supernatant and was compared among the bacteria, fungi, and LPS groups. RESULTS: Presepsin was increased in 11 patients with fungal bloodstream infections. Serial measurement of presepsin levels demonstrated a prompt decrease in 7 patients in whom treatment was effective, but no decrease or further increase in the patients with poor improvement. Additionally, presepsin concentrations were significantly correlated with the Sequential Organ Failure Assessment score (r = 0.89, p < 0.001). In vitro assay with co-incubation of C. albicans and human whole blood cells indicated that the viable cells of C. albicans caused an increase in presepsin, as seen with E. coli. CONCLUSIONS: Plasma presepsin levels increased in patients with fungal bloodstream infection, with positive association with the disease severity. Presepsin could be a useful biomarker of sepsis secondary to fungal infections.

    DOI: 10.1371/journal.pone.0206089

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  • The Effect of Intravenous Gamma-globulin Reagents on the Measurement Results of (1→3)-β-D-glucan

    茂呂寛, 古塩奈央, 番場祐基, 小泉健, 張仁美, 青木信将, 林正周, 津畑千佳子, 坂上亜希子, 佐藤瑞穂, 坂上拓郎, 小屋俊之, 田邊嘉也, 菊地利明

    感染症学雑誌   91 ( 1 )   1 - 6   2017.1

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MISC

Presentations

  • A case of V-V ECMO introduction to severely obese patient (BMI 70) with COVID-19 pneumonia

    青木志門, 本田博之, 玉川大朗, 番場祐基, 土田雅史, 晝間優隆, 松井亨, 新田正和, 本多忠幸, 西山慶

    日本集中治療医学会学術集会(Web)  2022 

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    Event date: 2022

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  • Rehabilitation under sedation and analgesia may be possible even in the extreme stages of tetanus.

    晝間優隆, 本田博之, 玉川大朗, 青木志門, 番場祐基, 土田雅史, 松井亨, 新田正和, 本多忠幸, 西山慶, 西山慶

    日本集中治療医学会学術集会(Web)  2022 

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  • A case of multiple organ failure with hepatitis-like course after status epilepticus.

    土田雅史, 本田博之, 晝間優隆, 青木志門, 玉川大朗, 番場祐基, 松井亨, 新田正和, 本多忠幸, 西山慶

    日本集中治療医学会学術集会(Web)  2022 

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  • 早期栄養介入管理加算取得に関する栄養管理部との連携と,加算取得開始前後での診療内容・患者転帰の変化

    新田正和, 小師優子, 今井十夢, 武田安永, 上村夏生, 八幡えり佳, 土田雅史, 番場祐基, 本多忠幸, 松井亨, 晝間優隆, 青木信将, 本田博之, 寺井崇二, 西山慶

    東北救急医学会総会・学術集会・日本救急医学会東北地方会プログラム・抄録集  2021 

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    Event date: 2021

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  • 誤嚥性肺炎の禁食期間と予後の検討

    小泉 健, 近 幸吉, 原 勝人, 島津 翔, 尾方 英至, 永野 啓, 里方 真理子, 番場 祐基, 張 仁美, 青木 信将, 佐藤 瑞穂, 坂上 亜希子, 茂呂 寛, 菊地 利明, 長谷川 隆志, 鈴木 榮一, 田邊 嘉也, 塚田 弘樹

    感染症学雑誌  2019.3  (一社)日本感染症学会

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    Event date: 2019.3

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  • 血流感染症における鉄制御因子Lipocalin2の動態について

    茂呂 寛, 番場 祐基, 永野 啓, 小泉 健, 青木 信将, 菊地 利明

    感染症学雑誌  2019.3  (一社)日本感染症学会

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    Event date: 2019.3

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  • 肺MAC症の経過における鉄代謝の動態について

    茂呂 寛, 番場 祐基, 小泉 健, 大嶋 康義, 菊地 利明

    結核  2019.3  (一社)日本結核・非結核性抗酸菌症学会

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  • 壊死性気管気管支炎の病像を呈した気管気管支アスペルギルス症の2例

    尾方 英至, 青木 信将, 袴田 真理子, 永野 啓, 島津 翔, 番場 祐基, 小泉 健, 張 仁美, 佐藤 瑞穂, 坂上 亜希子, 茂呂 寛, 菊地 利明, 中枝 武司, 和田 庸子, 成田 一衛

    感染症学雑誌  2019.1  (一社)日本感染症学会

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    Event date: 2019.1

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  • 臨床検体を用いた血中(1-3)-β-D-グルカン測定キット国内外4種類の比較検討

    永野 啓, 番場 祐基, 尾方 英至, 袴田 真理子, 島津 翔, 小泉 健, 青木 信将, 茂呂 寛, 菊地 利明

    感染症学雑誌  2019.1  (一社)日本感染症学会

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  • 636. The Hepcidin-25 and Iron Kinetics During the Acute Phase of Systemic Infection.

    Moro H, Bamba Y, Nagano K, Koizumi T, Aoki N, Ohshima Y, Watanabe S, Koya T, Takada T, Kikuchi T

    Open Forum Infectious Diseases  2018.11 

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    Event date: 2018.11

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  • 真菌血流感染症における敗血症バイオマーカーPresepsinの挙動とその有用性

    番場 祐基, 茂呂 寛, 里方 真理子, 尾方 英至, 小泉 健, 青木 信将, 林 正周, 坂上 拓郎, 小屋 俊之, 菊地 利明

    感染症学雑誌  2018.5  (一社)日本感染症学会

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    Event date: 2018.5

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  • CRP上昇を伴わない黄色ブドウ球菌感染症を繰り返し抗IL-6自己抗体の存在が疑われた1例

    吉澤 和孝, 坂上 拓郎, 番場 祐基, 青木 亜美, 林 正周, 青木 信将, 茂呂 寛, 田邊 嘉也, 長谷川 隆志, 小屋 俊之, 菊地 利明

    感染症学雑誌  2018.5  (一社)日本感染症学会

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  • 高齢者肺炎入院症例のADL低下の原因の検討

    小泉 健, 近 幸吉, 里方 真理子, 尾方 英至, 番場 祐基, 青木 信将, 張 仁美, 津畑 千佳子, 坂上 亜希子, 佐藤 瑞穂, 茂呂 寛, 田邊 嘉也, 塚田 弘樹, 長谷川 隆志, 鈴木 榮一, 菊地 利明

    感染症学雑誌  2018.5  (一社)日本感染症学会

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  • 自己免疫疾患に対して免疫抑制療法中の患者におけるサイトメガロウイルス感染のリスク因子の検討

    尾方 英至, 里方 真理子, 番場 祐基, 小泉 健, 青木 信将, 津畑 千佳子, 坂上 亜希子, 佐藤 瑞穂, 茂呂 寛, 菊地 利明

    日本化学療法学会雑誌  2018.4  (公社)日本化学療法学会

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    Event date: 2018.4

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  • 市中病院における医療介護関連肺炎の治療状況

    小泉 健, 近 幸吉, 里方 真理子, 尾方 英至, 番場 祐基, 青木 信将, 張 仁美, 津畑 千佳子, 坂上 亜希子, 佐藤 瑞穂, 茂呂 寛, 田邊 嘉也, 塚田 弘樹, 長谷川 隆志, 鈴木 榮一, 菊地 利明

    日本化学療法学会雑誌  2018.4  (公社)日本化学療法学会

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  • 深在性真菌症における各β-D-グルカン測定試薬の比較

    番場 祐基, 茂呂 寛, 里方 真理子, 尾方 英至, 小泉 健, 青木 信将, 林 正周, 坂上 拓郎, 小屋 俊之, 菊地 利明

    日本化学療法学会雑誌  2018.4  (公社)日本化学療法学会

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  • 肺抗酸菌症 病態解析 肺MAC症におけるサイトカインの網羅的解析

    番場 祐基, 茂呂 寛, 青木 信将, 朝川 勝明, 林 正周, 大嶋 康義, 渡部 聡, 坂上 拓郎, 阿部 徹哉, 小屋 俊之, 高田 俊範, 菊地 利明

    日本呼吸器学会誌  2017.3  (一社)日本呼吸器学会

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    Event date: 2017.3

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  • 菌血症・敗血症の急性期における鉄代謝 鉄調節因子Hepcidin-25の動態をふまえて

    茂呂 寛, 番場 祐基, 小泉 健, 青木 信将, 林 正周, 坂上 拓郎, 小屋 俊之, 田邊 嘉也, 菊地 利明

    感染症学雑誌  2017.3  (一社)日本感染症学会

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  • 肺MAC症におけるサイトカインの網羅的解析

    番場祐基, 茂呂寛, 青木信将, 朝川勝明, 林正周, 大嶋康義, 渡部聡, 坂上拓郎, 阿部徹哉, 小屋俊之, 高田俊範, 菊地利明

    日本呼吸器学会誌(Web)  2017 

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  • 菌血症・敗血症の急性期における鉄代謝~鉄調節因子Hepcidin-25の動態をふまえて

    茂呂寛, 番場祐基, 小泉健, 青木信将, 林正周, 坂上拓郎, 小屋俊之, 田邊嘉也, 菊地利明

    日本化学療法学会雑誌  2017 

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  • クリゾチニブ耐性症例に対するアレクチニブの有効性に関する検討

    番場 祐基, 岡島 正明, 佐藤 昂, 近藤 利恵, 三浦 理, 渡部 聡, 田中 純太, 各務 博, 菊地 利明

    肺癌  2015.10  (NPO)日本肺癌学会

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    Event date: 2015.10

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  • 脳梗塞再発時に聴覚失認を呈した71歳男性例

    番場 祐基, 酒井 直子, 田部 浩行

    臨床神経学  2015.1  (一社)日本神経学会

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    Event date: 2015.1

    Language:Japanese  

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