Updated on 2026/03/18

写真a

 
KISUPE Sarusedo Anhera
 
Organization
Academic Assembly Institute of Medicine and Dentistry SHIGAKU KEIRETU Assistant Professor
Graduate School of Medical and Dental Sciences Oral Life Science Tissue Regeneration and Reconstruction Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
Other name(s)
Angie
External link

Degree

  • 博士（歯学） ( 2014.9   新潟大学 )

Research Interests

  • Pulp Biology

  • Oral Histology

  • Tissue Regeneration

  • Tooth Development

  • Oral Anatomy

  • Gross Anatomy

  • Craniofacial Developmental Biology

  • Hard tissue

Research Areas

  • Life Science / Regenerative dentistry and dental engineering

  • Life Science / Developmental dentistry

  • Life Science / Oral biological science

  • Life Science / Anatomy

Research History (researchmap)

  • Faculty of Dentistry, Niigata University – Niigata, Japan.   Division of Anatomy and Cell Biology of the Hard Tissue

    2022.3

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  • Faculty of Dentistry, Niigata University - Niigata, Japan.   Division of Anatomy and Cell Biology of the Hard Tissue

    2021.5 - 2022.2

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  • School of Dentistry, Niigata University - Niigata, Japan   Division of Anatomy and Cell Biology of the Hard Tissue   Visiting researcher

    2019.8

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  • Científica del Sur University - Lima, Peru.   School of Stomatology   Adjunct faculty / Associated researcher

    2018.3 - 2021.5

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  • Center of Dental Medicine, University of Zurich - Zurich, Switzerland.   Institute of Oral Biology   Visiting postdoctoral researcher

    2017.9 - 2018.2

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  • New York University College of Dentistry - New York, USA.   Department of Basic Science and Craniofacial Biology   Postdoctoral associate

    2015.8 - 2017.2

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  • School of Dentistry, University of Texas at Houston - Texas, USA.   Center for Craniofacial Biology   Postdoctoral researcher

    2015.4 - 2015.7

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Research History

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Assistant Professor

    2022.3

  • Niigata University   Tissue Regeneration and Reconstruction, Oral Life Science, Graduate School of Medical and Dental Sciences   Assistant Professor

    2022.3

Education

  • Niigata University   Faculty of Dentistry   PhD. in Oral Life Sciences

    2010.10 - 2014.9

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    Country： Japan

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  • Los Andes Private University   School of Stomatology   Master of Science in Stomatology

    2008.4 - 2010.3

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    Country： Peru

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  • National University of San Marcos   Faculty of Dentistry   DDS

    2001.4 - 2006.12

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    Country： Peru

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Professional Memberships

  • International Association of Dental Traumatology (IADT)

    2023

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  • The Japanese Society for Regenerative Medicine

    2022

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  • Japanese Association for Oral Biology (JAOB)

    2011

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  • The Japanese Association of Anatomists (JAA)

    2011

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  • International Association for Dental Research (IADR)

    2009

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Papers

  • Stress Distribution in a Mandibular Kennedy class I Restored with Bilateral Implant-Assisted Removable Partial Denture: A Finite Element Analysis

    Dagny Ochoa-Escate, Freddy Valdez-Jurado, Romel Watanabe, Martha Pineda Mejía, Edwin Antonio Córdova Huayanay, Maria Soledad Ventocilla Huasupoma, Marcos Herrera Cisneros, Giovanna Lujan Larreátegui, Angela Quispe-Salcedo, Doris Salcedo-Moncada, Jesús Julio Ochoa Tataje

    2025.2

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  • Pulpal Responses to Leukocyte- and Platelet-Rich Plasma Treatment in Mouse Models for Immediate and Intentionally Delayed Tooth Replantation

    Angela Quispe-Salcedo, Kiyoko Suzuki-Barrera, Mauricio Zapata-Sifuentes, Taisuke Watanabe, Tomoyuki Kawase, Hayato Ohshima

    Applied Sciences   2024.12

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/app142311358

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  • マウス歯の再植時の意図的穿孔形成がマクロファージの時空間ダイナミクスに与える影響

    佐野 拓人, 大島 邦子, Quispe-Salcedo A., 岡田 康男, 佐藤 拓一, 大島 勇人

    Journal of Oral Biosciences Supplement   2024   [P1 - 13]   2024.11

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    Language：Japanese   Publisher：(一社)歯科基礎医学会  

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  • マウス歯の再植時の意図的穿孔形成がマクロファージの時空間ダイナミクスに与える影響

    佐野 拓人, 大島 邦子, Quispe-Salcedo A., 岡田 康男, 佐藤 拓一, 大島 勇人

    Journal of Oral Biosciences Supplement   2024   [P1 - 13]   2024.11

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    Language：Japanese   Publisher：(一社)歯科基礎医学会  

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  • Bases moleculares de la patogénesis del ameloblastoma: una revisión

    Grecia Lourdes Riofrio Chung, Tania Lisseth Santos Tucto, Angela Quispe-Salcedo

    Revista Científica Odontológica   2024.9

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.21142/10.21142/2523-2754-1203-2024-212

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  • Effects of Synthetic Toll-Like Receptor 9 Ligand Molecules on Pulpal Immunomodulatory Response and Repair after Injuries. International journal

    Angela Quispe-Salcedo, Tomohiko Yamazaki, Hayato Ohshima

    Biomolecules   14 ( 8 )   2024.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Synthetic oligodeoxynucleotides (ODNs) containing unmethylated cytosine-phosphate-guanine (CpG) motifs (CpG-ODNs) are ligand molecules for Toll-like receptor 9 (TLR9), which is expressed by odontoblasts in vitro and dental pulp cells. This study determined the effects of CpG-ODNs on pulpal immunomodulatory response and repair following injury. Briefly, the upper right first molars of three-week-old mice were extracted, immersed in Type A (D35) or B (K3) CpG-ODN solutions (0.1 or 0.8 mM) for 30 min, and then replanted. Pulpal healing and immunomodulatory activity were assessed by hematoxylin-eosin and AZAN staining, as well as immunohistochemistry. One week following the operation, inflammatory reactions occurred in all of the experimental groups; however, re-revascularization and newly formed hard tissue deposition were observed in the pulp chamber of all groups at week 2. A positive trend in the expression of immune cell markers was observed toward the CpG-ODN groups at 0.1 mM. Our data suggest that synthetic CpG-ODN solutions at low concentrations may evoke a long-lasting macrophage-TLR9-mediated pro-inflammatory, rather than anti-inflammatory, response in the dental pulp to modulate the repair process and hard tissue formation. Further studies are needed to determine the effects of current immunomodulatory agents in vitro and in vivo and develop treatment strategies for dental tissue regeneration.

    DOI： 10.3390/biom14080931

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  • Effects on dentin nanomechanical properties, cell viability and dentin wettability of a novel plant-derived biomodification monomer. International journal

    Mário A Moreira, Madiana M Moreira, Diego Lomonaco, Eduardo Cáceres, Lukasz Witek, Paulo G Coelho, Emi Shimizu, Angela Quispe-Salcedo, Victor P Feitosa

    Dental materials : official publication of the Academy of Dental Materials   2024.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVES: To evaluate the effects of dentin biomodification agents (Proanthocyanidin (PAC), Cardol (CD) and Cardol-methacrylate (CDMA) on dentin hydrophilicity by contact angle measurement, viability of dental pulp stem cells (DPSCs) and nanomechanical properties of the hybrid layer (HL). METHODS: CDMA monomer was synthesized from cardol through methacrylic acid esterification. Human extracted third molars were used for all experiments. For nanomechanical tests, specimens were divided in four groups according to the primer solutions (CD, CDMA, PAC and control) were applied before adhesive and composite coating. Nanomechanical properties of the HL were analyzed by nanoindentation test using a Berkovich probe in a nanoindenter. Wettability test was performed on dentin surfaces after 1 min biomodification and measured by contact angle analysis. Cytotoxicity was assessed by a MTT assay with DPSCs after 48 and 72 h. Data were analyzed with Student's t test or Two-way ANOVA and Tukey HSD test (p < 0.05). RESULTS: CD and CDMA solutions achieved greater hydrophobicity and increased the water-surface contact angles when compared to PAC and control groups (p < 0.05). PAC group showed a greater reduction of elastic modulus in nanoindentation experiments when compared to CD and CDMA groups (p < 0.05) after 4 months of aging. CD inhibited cell proliferation compared to all further materials (p < 0.05), whilst CDMA and PAC indicated no cell cytotoxicity to human DPSCs. SIGNIFICANCE: Cardol-methacrylate provided significantly higher hydrophobicity to dentin and demonstrated remarkable potential as collagen crosslinking, attaining the lowest decrease of HL's mechanical properties. Furthermore, such monomer did not affect pulp cytotoxicity, thereby highlighting promising feasibility for clinical applications.

    DOI： 10.1016/j.dental.2024.07.010

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  • Early revascularization activates quiescent dental pulp stem cells following tooth replantation in mice International journal

    Hiroto Sano, Kuniko Nakakura-Ohshima, Angela Quispe-Salcedo, Yasuo Okada, Takuichi Sato, Hayato Ohshima

    Regenerative Therapy   24   582 - 591   2023.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    INTRODUCTION: The intentional perforation of the pulp chamber floor before tooth replantation promotes pulpal healing by facilitating the revascularization of the pulp cavity. This study aimed to elucidate the effects of this method on the dynamics of quiescent dental pulp stem cells (DPSCs). METHODS: The right and left maxillary first molars of Crlj:CD1 mice and TetOP-histone 2B (H2B)-green fluorescent protein (GFP) mice were extracted. The left molars were immediately replanted as the control group (CG), whereas the pulp chamber floor of the right molars were perforated before the tooth was replanted as the experimental group (EG). Immunohistochemistry for Nestin and GFP, and quantitative RT-PCR for Nestin, Opn, CD11c, and Oct3/4 mRNA were performed. RESULTS: The rate of Nestin-positive perimeter along the pulp-dentin border in the EG tended to be higher than that of the CG at days 5 and 7 and was significantly increased between days 3 and 7. The rate of GFP-positive cells in the EG was significantly higher than that of the CG at days 5 and/or 7 in the mesial and middle coronal pulp. CD11c mRNA in the EG at day 5 was significantly higher than that of the CG and tended to be higher than that of the CG during the observation period. Oct3/4 mRNA expression in the EG was significantly higher than that of the CG at day 7. CONCLUSIONS: The current experimental model demonstrated the promotion of the survival of DPSCs and their differentiation into odontoblast-like cells (OBLCs). Thus, the use of this model is expected to clarify the crosstalk mechanism between immune cells, including macrophages and dendritic cells, and DPSCs with regards to pulpal healing after tooth replantation. It also provides insight into the differentiation process of DPSCs into OBLCs.

    DOI： 10.1016/j.reth.2023.10.004

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  • Mujeres en ciencia: Los desafíos de las dentistas-científicas en Perú

    Angela Quispe-Salcedo

    Odontología Sanmarquina   26 ( 3 )   2023.9

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    Authorship：Lead author,　Corresponding author   Language：Spanish, Castilian   Publishing type：Research paper (scientific journal)  

    El rol de la mujer en la ciencia, especialmente en STEM (Ciencia, tecnología, ingeniería y matemáticas; por sus siglas en inglés) ha avanzado dramáticamente a través de los años, a pesar de todos los obstáculos característicos de cada siglo 1. La estructura social había considerado a la mujer como cuidadora de la casa y de los niños, además de ser consideradas inferiores en términos de intelecto y empleo 2. Áreas como medicina y la naciente odontología, que en el siglo diecinueve estaban dominadas por hombres, albergan ahora en las aulas universitarias grupos igualitarios de estudiantes de ambos géneros. Aun cuando el progreso es evidente en cuanto al acceso a la formación profesional en ciencias de la salud, el camino hacia la obtención de puestos de responsabilidad mayor, o toma de decisiones, sigue siendo desigual para las mujeres en estas áreas.

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  • Importancia de la técnica de perfusión intracardiaca para los estudios in vivo en Odontología

    Mauricio Andre Zapata-Sifuentes, Kiyoko Suzuki-Barrera, Angela Quispe-Salcedo

    Revista Científica Odontológica   2023.3

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.21142/2523-2754-1101-2023-148

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  • Explorando nuevos horizontes mediante la promoción de Programas de rotación de pregrado entre estudiantes de Odontología

    Angela Quispe-Salcedo

    Revista Científica Odontológica   2023.3

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.21142/2523-2754-1101-2023-138

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  • Perspectives on peer-review and editorial activities of Peruvian dental researchers. International journal

    Angela Quispe-Salcedo

    Revista cientifica odontologica (Universidad Cientifica del Sur)   11 ( 4 )   e170   2023

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.21142/2523-2754-1104-2023-170

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  • [Importance of intracardiac perfusion fixation technique for in vivo studies in dentistry]. International journal

    Mauricio Andre Zapata-Sifuentes, Kiyoko Suzuki-Barrera, Angela Quispe-Salcedo

    Revista cientifica odontologica (Universidad Cientifica del Sur)   11 ( 1 )   e148   2023

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    Authorship：Last author,　Corresponding author   Language：Spanish, Castilian   Publishing type：Research paper (scientific journal)  

    In vivo studies in dentistry require a high level of precision, since they involve the experimentation with a living organism, and further comprehensive histological analysis to validate the initial hypothesis. However, the process to obtained the histological slides to be studied is often wrongly minimized. In order to obtain high quality histological sections, which may be able to react favorably to more complex immunological techniques, it is necessary to preserve or "fix" the tissues of interest in an optimal manner. Intracardiac perfusion fixation has been described as a technique that offers superior results to other tissue fixation methods, allowing not only adequate sample stability, but also a deep cleansing and hardening of the tissues to allow further manipulation. Through a variation of the technique, it is possible to occlude the main arterial supply of the abdominal region to maintain direct perfusion of the fixator in the region of interest, such as the maxillofacial and thoracic region.

    DOI： 10.21142/2523-2754-1101-2023-148

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  • Actividad inhibitoria del extracto etanólico del Cyperus Rotundus procedente de la región de Cajamarca (provincia de Contumazá) en una cepa estandarizada de Streptococcus mutans (ATCC®25175) International journal

    Rosita Belén Bazán Aliaga, Óscar Reátegui Arévalo, Luz Verónica Solórzano Espinoza, Juan Antonio Castro Arredondo, Víctor Elmo Miranda García, Elba Estefanía Martínez Cadillo, Angela Quispe-Salcedo

    Revista Científica Odontológica   10 ( 1 )   e093   2022.4

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    Authorship：Last author,　Corresponding author   Language：Spanish, Castilian   Publishing type：Research paper (scientific journal)   Publisher：Universidad Cientifica del Sur  

    OBJECTIVE: The purpose of this study was to determine in vitro the inhibitory activity of the ethanolic extract of Cyperus rotundus (Cajamarca - Contumazá) against a standardize strain of Streptococcus mutans (ATCC®25175™). MATERIALS AND METHODS: This study was an experimental in vitro study, which consisted of determining the inhibitory effect of three concentrations of the ethanolic extract of Cyperus rotundus: 250 mg/ml, 500 mg/ml, and 1000 mg/ml against a strains of Streptococcus mutans (ATCC®25175™). Ten tests were performed for each concentration, having 0.12% chlorhexidine as a positive control for Streptococcus mutans plates and 10% DMSO as a negative control. To evaluate the inhibitory effect, the disk diffusion method or Kirby-Bauer test was used, reading the results at 48 hours after initial sowing. RESULTS: None of the three concentrations of the ethanolic extract of Cyperus rotundus demosntrated inhibitory effects on the Streptococcus mutans strain; however, the positive control, chlorhexidine, clearly showed inhibition halos of 14.43 mm ± 1.23 mm after 48 hours of incubation. CONCLUSIONS: The ethanolic extract of Cyperus rotundus did not inhibit the growth of Streptococcus mutans. It is recommended to deepen the chemical analysis of the components of this plant and explore other extraction methods to verify its bacteriostatic action versus other oral and non-oral microorganisms.

    DOI： 10.21142/2523-2754-1001-2022-093

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  • The Critical Role of MMP13 in Regulating Tooth Development and Reactionary Dentinogenesis Repair Through the Wnt Signaling Pathway International journal

    Henry F. Duncan, Yoshifumi Kobayashi, Yukako Yamauchi, Angela Quispe-Salcedo, Zhi Chao Feng, Jia Huang, Nicola C. Partridge, Teruyo Nakatani, Jeanine D’Armiento, Emi Shimizu

    Frontiers in Cell and Developmental Biology   10   883266 - 883266   2022.4

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    DOI： 10.3389/fcell.2022.883266

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  • Exploration of the role of the subodontoblastic layer in odontoblast-like cell differentiation after tooth drilling using Nestin-enhanced green fluorescent protein transgenic mice International journal

    Chihiro Imai, Hiroto Sano, Angela Quispe-Salcedo, Kotaro Saito, Mitsushiro Nakatomi, Hiroko Ida-Yonemochi, Hideyuki Okano, Hayato Ohshima

    Journal of Oral Biosciences   64 ( 1 )   77 - 84   2022.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.job.2022.01.001

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  • Grupos de investigación: juntos llegamos lejos

    Angela Quispe-Salcedo

    Revista Científica Odontológica   2021.10

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.21142/2523-2754-0903-2021-066

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  • The effects of reducing the root length by apicoectomy on dental pulp revascularization following tooth replantation in mice International journal

    Kuniko Nakakura-Ohshima, Angela Quispe-Salcedo, Hiroto Sano, Haruaki Hayasaki, Hayato Ohshima

    DENTAL TRAUMATOLOGY   37 ( 5 )   677 - 690   2021.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/edt.12679

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  • The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis International journal

    Angela Quispe-Salcedo, Hayato Ohshima

    JOURNAL OF CLINICAL MEDICINE   10 ( 15 )   2021.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/jcm10153348

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  • Ezh2 knockout in mesenchymal cells causes enamel hyper- mineralization International journal

    Yoshifumi Kobayashi, Angela Quispe-Salcedo, Sanika Bodas, Satoko Matsumura, Erhao Li, Richard Johnson, Marwa Choudhury, Daniel H. Fine, Siva Nadimpalli, Henry F. Duncan, Amel Dudakovic, Andre J. van Wijnen, Emi Shimizu

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   567   72 - 78   2021.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2021.06.003

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  • [Research groups: together we reach further]. International journal

    Angela Quispe-Salcedo

    Revista cientifica odontologica (Universidad Cientifica del Sur)   9 ( 3 )   e066   2021

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    Authorship：Lead author,　Corresponding author   Language：Spanish, Castilian  

    DOI： 10.21142/2523-2754-0903-2021-066

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  • [Basic dental sciences as the foundations for clinical practice]. International journal

    Angela Quispe-Salcedo

    Revista cientifica odontologica (Universidad Cientifica del Sur)   9 ( 2 )   e053   2021

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    Authorship：Lead author,　Corresponding author   Language：Spanish, Castilian  

    DOI： 10.21142/2523-2754-0902-2021-053

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  • An overview of Peruvian dental research in time of COVID-19

    Angela Quispe-Salcedo

    Revista Científica Odontológica   2020.12

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.21142/2523-2754-0803-2020-027

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  • Responses of oral-microflora-exposed dental pulp to capping with a triple antibiotic paste or calcium hydroxide cement in mouse molars International journal

    Angela Quispe-Salcedo, Takuichi Sato, Junko Matsuyama, Hiroko Ida-Yonemochi, Hayato Ohshima

    REGENERATIVE THERAPY   15   216 - 225   2020.12

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.reth.2020.10.001

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  • Promotion of education and research in dental basic science. A call for action

    Vilma Chuquihuaccha-Granda, Angela Quispe-Salcedo

    Journal of Oral Research   9 ( 6 )   446 - 448   2020.11

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    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.17126/joralres.2020.100

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  • COVID-19 y su impacto en la odontología peruana

    Angela Quispe-Salcedo

    Revista Científica Odontológica   8 ( 1 )   1 - 2   2020.4

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Universidad Cientifica del Sur  

    DOI： 10.21142/2523-2754-0801-2020-001

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  • Estudio in vitro del Efecto Antibacteriano de la Oleorresina de Copaifera reticulata y el Aceite Esencial de Origanum majoricum Frente a Streptococcus mutans y Enterococcus Faecalis Bacterias de Importancia en Patologías Orales

    Angela Quispe-Salcedo

    International journal of odontostomatology   2018.12

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    Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4067/s0718-381x2018000400355

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  • La importancia de las ciencias básicas en la formación del cirujano dentista

    Angela Quispe-Salcedo

    Odontología Sanmarquina   2018.9

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    <jats:p>Explicar la ciencia no es tarea sencilla. Desde una aproximación actual, la ciencia puede definirse como una descripción sistemática de un determinado fenómeno presente en la naturaleza 1; donde la observación y la interpretación se interrelacionan para dar lugar a un nuevo conocimiento que se estandariza mediante el uso del método científico. Dentro de este contexto, la ciencia puede ser dividida en básica y aplicada, teniendo cada una características y objetivos distintos.</jats:p>

    DOI： 10.15381/os.v21i3.15145

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  • Nestin expression is differently regulated between odontoblasts and the subodontoblastic layer in mice International journal

    Mitsushiro Nakatomi, Angela Quispe-Salcedo, Masaka Sakaguchi, Hiroko Ida-Yonemochi, Hideyuki Okano, Hayato Ohshima

    HISTOCHEMISTRY AND CELL BIOLOGY   149 ( 4 )   383 - 391   2018.4

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    DOI： 10.1007/s00418-018-1651-3

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  • IGF-1 Mediates EphrinBl Activation in Regulating Tertiary Dentin Formation

    S. Matsumura, A. Quispe-Salcedo, C. M. Schiller, J. S. Shin, B. M. Locke, S. Yakar, E. Shimizu

    Journal of Dental Research   96 ( 10 )   1153 - 1161   2017.9

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    DOI： 10.1177/0022034517708572

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  • Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development International journal

    Walid D. Fakhouri, Kareem Metwalli, Ali Naji, Sarah Bakhiet, Angela Quispe-Salcedo, Larissa Nitschke, Youssef A. Kousa, Brian C. Schutte

    SCIENTIFIC REPORTS   7 ( 1 )   7129 - 7129   2017.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-017-06310-z

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  • The effects of enzymatically synthesized glycogen on the pulpal healing process of extracted teeth following intentionally delayed replantation in mice

    Angela Quispe-Salcedo, Hiroko Ida-Yonemochi, Hayato Ohshima

    JOURNAL OF ORAL BIOSCIENCES   57 ( 2 )   124 - 130   2015.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.job.2015.01.003

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  • Effects of a Triple Antibiotic Solution on Pulpal Dynamics after Intentionally Delayed Tooth Replantation in Mice International journal

    Angela Quispe-Salcedo, Hiroko Ida-Yonemochi, Hayato Ohshima

    JOURNAL OF ENDODONTICS   40 ( 10 )   1566 - 1572   2014.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.joen.2014.05.005

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  • Use of a triple antibiotic solution affects the healing process of intentionally delayed replanted teeth in mice

    Angela Quispe-Salcedo, Hiroko Ida-Yonemochi, Hayato Ohshima

    JOURNAL OF ORAL BIOSCIENCES   55 ( 2 )   91 - 100   2013.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.job.2013.03.001

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  • Expression patterns of nestin and dentin sialoprotein during dentinogenesis in mice

    Angela Quispe-Salcedo, Hiroko Ida-Yonemochi, Mitsushiro Nakatomi, Hayato Ohshima

    BIOMEDICAL RESEARCH-TOKYO   33 ( 2 )   119 - 132   2012.4

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    Authorship：Lead author   Language：English  

    DOI： 10.2220/biomedres.33.119

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MISC

  • マウス顎骨へのインプラント埋入後のオッセオインテグレーションへのリンパ球-多血小板血漿(L-PRP)の効果

    ZAPATASIFUENTES Mauricio Andre, QUISPE-SALCEDO Angela, WATANABE Taisuke, OHSHIMA Hayato

    新潟歯学会雑誌   54 ( 1 )   2024

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  • EFFECT OF LEUKOCYTE PLATELET-RICH PLASMA ON OSSEOINTEGRATION OF IMPLANTS PLACED IN THE MOUSE MAXILLA

    ZAPATA-SIFUENTES Mauricio, QUISPE-SALCEDO Angela, 渡辺泰典, 川瀬知之, 大島勇人

    日本再生医療学会総会(Web)   23rd   2024

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  • Effects of synthetic CpG oligodeoxynucleotides on the healing process of heavily injured tooth pulp

    ANGELA Quispe-Salcedo, ANGELA Quispe-Salcedo, 山崎智彦, 依田浩子, 大島勇人

    日本再生医療学会総会(Web)   22nd   2023

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  • Effectiveness of Leukocyte- and Platelet-Rich Plasma (L-PRP) on the pulpal healing process following tooth replantation in mice

    QUISPE-SALCEDO Angela, ZAPATA-SIFUENTES Mauricio, WATANABE Taisuke, KAWASE Tomoyuki, OHSHIMA Hayato

    Journal of Oral Biosciences Supplement (Web)   2023   2023

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  • The positive effects of leukocyte- and platelet-rich plasma (l-prp) on osseointegration after implant placement in mouse maxilla

    ZAPATA-SIFUENTES Mauricio Andre, QUISPE-SALCEDO Angela, WATANABE Taisuke, KAWASE Tomoyuki, OHSHIMA Hayato

    Journal of Oral Biosciences Supplement (Web)   2023   2023

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  • マウス臼歯再植後の早期血行回復は歯髄静的幹細胞を賦活化する

    佐野拓人, 大島邦子, QUISPE-SALCEDO Angela, 岡田康男, 佐藤拓一, 大島勇人

    Journal of Oral Biosciences Supplement (Web)   2023   2023

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  • 象牙芽細胞におけるNestin遺伝子の発現制御機構

    中富 満城, Quispe-Salcedo Angela, 依田 浩子, 大島 勇人, 岡野 栄之

    Journal of Oral Biosciences Supplement   2016   471 - 471   2016.9

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    Language：Japanese   Publisher：(一社)歯科基礎医学会  

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  • 象牙芽細胞におけるNestin遺伝子の発現制御機構

    中富満城, QUISPE-SALCEDO Angela, 依田浩子, 大島勇人

    Journal of Oral Biosciences Supplement (Web)   2016   2016

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  • 三種混合抗菌性薬剤と水酸化カルシウムセメント覆髄に対する感染歯髄の反応

    Quispe-Salcedo Angela, 大島 勇人, 武藤 徳子, 石井 信之

    神奈川歯学   50 ( 抄録集 )   72 - 72   2015.11

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    Language：Japanese   Publisher：神奈川歯科大学学会  

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  • Root resection accelerates the dental pulp regeneration following tooth replantation in mice

    QUISPE-SALCEDO Angela, IDA-YONEMOCHI Hiroko, OHSHIMA Hayato

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   119th   2014

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  • 酵素合成グリコーゲンによる歯の再植後の歯髄治癒促進効果について

    大島勇人, QUISPE-SALCEDO Angela, 高田洋樹, 依田浩子

    再生医療   13   2014

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  • マウスの意図的に遅延した歯の生え替わり後の治癒過程に対する酵素的に合成したグリコーゲン(ESG)の有効性(Effectiveness of Enzymatically Synthesized Glycogen (ESG) on the healing process following intentionally-delayed tooth replantation in mice)

    Quispe-Salcedo Angela, 依田 浩子, 大島 勇人

    Journal of Oral Biosciences Supplement   2013   123 - 123   2013.9

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    Language：English   Publisher：(一社)歯科基礎医学会  

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  • 離乳前後および成熟マウスの口腔内プラーク常在菌叢の網羅的解析

    松山 順子, 佐藤 拓一, Quispe-Salcedo Angela, 高橋 信博, 大島 勇人

    Journal of Oral Biosciences Supplement   2013   223 - 223   2013.9

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    Language：Japanese   Publisher：(一社)歯科基礎医学会  

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  • 離乳前後および成熟マウスの口腔内プラーク常在菌叢の網羅的解析

    松山順子, 佐藤拓一, QUISPE-SALCEDO Angela, 高橋信博, 大島勇人

    Journal of Oral Biosciences Supplement (Web)   2013   2013

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  • Effectiveness of Enzymatically Synthesized Glycogen(ESG)on the healing process following intentionally-delayed tooth replantation in mice

    QUISPE-SALCEDO Angela, IDA Hiroko, OSHIMA Hayato

    Journal of Oral Biosciences Supplement (Web)   2013   2013

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  • 意図的に遅延した歯の再植後の歯髄の治癒過程における抗菌薬の有効性(Effectiveness of antimicrobials in the pulpal healing process following intentionally delayed tooth replantation)

    Quispe-Salcedo Angela, 依田 浩子, 大島 勇人

    Journal of Oral Biosciences Supplement   2012   85 - 85   2012.9

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    Language：English   Publisher：(一社)歯科基礎医学会  

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  • マウス口腔内プラーク常在菌叢の網羅的解析

    松山 順子, 佐藤 拓一, Quispe-Salcedo Angela, 石田 直子, 高橋 信博, 大島 勇人

    Journal of Oral Biosciences Supplement   2012   138 - 138   2012.9

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    Language：Japanese   Publisher：(一社)歯科基礎医学会  

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  • マウス口腔内プラーク常在菌叢の網羅的解析

    松山順子, 佐藤拓一, ANGELA Quispe-Salcedo, 石田直子, 石田直子, 高橋信博, 大島勇人

    Journal of Oral Biosciences Supplement (Web)   2012   2012

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  • Effectiveness of antimicrobials in the pulpal healing process following intentionally delayed tooth replantation

    QUISPE-SALCEDO Angela, IDA Hiroko, OSHIMA Hayato

    Journal of Oral Biosciences Supplement (Web)   2012   2012

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Presentations

  • In vivo assessment of synthetic toll-like receptor 9 ligand molecules for the treatment of the afflicted dental pulp following tooth replantation in mice

    Angela Quispe-Salcedo, Tomohiko Yamazaki, Hayato Ohshima

    22nd World Congress on Dental Traumatology 2024, Tokyo, Japan  2024.7 

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    Presentation type：Oral presentation (general)  

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  • Effects of synthetic toll-like receptor 9 ligand molecules on the pulpal immunomodulatory responses and repair after injuries

    Angela Quispe-Salcedo, 山崎智彦, 大島勇人

    129th Annual Meeting of the Japanese Association of Anatomists, Okinawa, Japan  2024.3 

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    Presentation type：Oral presentation (general)  

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  • Avances en la reacción de la pulpa dental

    Angela Quispe-Salcedo

    Congreso Internacional de la Facultad de Odontologia de laUniversidad Latina, Costa Rica (online)  2023.10 

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    Presentation type：Oral presentation (keynote)  

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  • Effectiveness of Leukocyte- and Platelet-Rich Plasma (L-PRP) on the pulpal healing process following tooth replantation in mice.

    Quispe-Salcedo A, Zapata-Sifuentes M, Watanabe T, Kawase T, Ohshima H

    The 65th Annual Meeting of the Japanese Association for Oral Biology. Tokyo, Japan.  2023.9 

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    Presentation type：Oral presentation (general)  

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  • Effects of synthetic CpG oligodeoxynucleotides on the healing process of heavily injured tooth pulp.

    Quispe-Salcedo A, Yamazaki T, Ohshima H

    22nd Annual Meeting of the Japanese Society for Regenerative Medicine. Kyoto, Japan.  2023.3 

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    Presentation type：Oral presentation (general)  

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  • The interaction between osteopontin and stem/progenitor cells determines the pulpal healing following tooth replantation in mice.

    Quispe-Salcedo A, Suzuki-Barrera K, Nakatomi M, Ida-Yonemochi H, Ohshima H

    The 64th Annual Meeting of the Japanese Association for Oral Biology. Tokushima, Japan.  2022.9 

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    Presentation type：Oral presentation (general)  

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  • Effectiveness of 3Mix-MP Paste as Pulp-Capping Agent in Murine Molars.

    Quispe-Salcedo A, Sato T, Matsuyama J, Ida-Yonemochi H, Ohshima H

    IADR/ AADR / CADR General Session Washington DC, USA.  2020 

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    Presentation type：Oral presentation (general)  

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  • Bases biológicas y evidencia científica del uso de la pasta triple antibiótica 3Mix en patologías pulpares.

    Quispe-Salcedo A

    VII Congreso de la Región Latinoamericana IADR. XIII Reunión Científica SUIO. Montevideo, Uruguay.  2018.8 

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    Presentation type：Oral presentation (invited, special)  

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  • Histone Methyltransferaase Ezh2 is Required for Enamel Maturation

    Quispe-Salcedo A, Matsumura S, Li E, Dudakovic A, van Wijnen AJ, Shimizu E

    IADR/ AADR / CADR General Session. San Francisco, California. USA.  2017.3 

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    Presentation type：Oral presentation (general)  

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  • ephrinB1 ligand is a critical mediator for tertiary dentinogénesis.

    Quispe-Salcedo A, Matsumura S, Schiller C, Yakar S, Shimizu E

    IADR Pulp biology and regeneration group symposium. Nagoya, Japon.  2016.6 

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    Presentation type：Poster presentation  

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  • Responses of infected dental pulp to capping with the mixture of three antibacterial drugs (3Mix) or calcium hydroxide cement in mouse molars.

    Quispe-Salcedo A, Sato T, Matsuyama J, Ohshima H

    The 56th Annual meeting of the Japanese Association for Oral Biology. Fukuoka, Japan  2014.9 

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    Presentation type：Oral presentation (general)  

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  • Root resection accelerates the dental pulp regeneration following tooth replantation in mice.

    Quispe-Salcedo A, Ohshima H

    The 119th Annual Meeting of the Japanese Association of Anatomists. Tochigi, Japan  2014.3 

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    Presentation type：Oral presentation (general)  

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  • The resection of the root accelerates pulpal regeneration following tooth replantation in mice.

    Quispe-Salcedo A, Ohshima H

    International Symposium Frontier Meeting. Niigata, Japan  2014.2 

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    Presentation type：Oral presentation (general)  

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  • Effectiveness of enzymatically synthesized glycogen (ESG) on the healing process following intentionally-delayed tooth replantation in mice.

    Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H

    The 55th Annual meeting of the Japanese Association for Oral Biology. Okayama, Japan  2013.9 

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    Presentation type：Oral presentation (general)  

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  • The use of antimicrobials accelerates the dental pulp regeneration following intentionally-delayed tooth replantation in mice.

    Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H

    11th International Conference on Tooth Morphogenesis and Differentiation. La Londe les Maures, France  2013.6 

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    Presentation type：Poster presentation  

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  • Expression of GFP and nestin immunoreactivity during postnatal tooth development in nestin-EGFP transgenic mice.

    Quispe-Salcedo A, Ida-Yonemochi H, Mitsushiro N, Nakagawa E, Saito K, Okano H, Ohshima H

    The 118th Annual Meeting of the Japanese Association of Anatomists. Takamatsu, Japan  2013.3 

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    Presentation type：Oral presentation (general)  

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  • The use of antimicrobials accelerates the pulpal healing process following intentionally-delayed tooth replantation in mice.

    Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H

    International Symposium Frontier Meeting: Development, Evolution, Taxonomy, and Genetics of Tooth Structure “Tooth Voyage, Up To Date”. Jeonju, South Korea  2013.2 

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    Presentation type：Oral presentation (general)  

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  • Effectiveness of antimicrobials in the pulpal healing process following intentionally delayed tooth replantation.

    Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H

    The 54th annual meeting of the Japanese Association for Oral Biology. Koriyama, Japan  2012.9 

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    Presentation type：Oral presentation (general)  

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  • The application of antimicrobials or glycogen accelerates the pulpal regeneration of replanted molars in mice. March 2012.

    Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H

    The 117th Annual Meeting of the Japanese Association of Anatomists. Yamanashi, Japan  2012.3 

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    Presentation type：Oral presentation (general)  

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  • Assessment of nestin and dentin sialoprotein expression patterns during dentinogenesis and aging.

    Quispe-Salcedo A, Ida-Yonemochi H, Mitsushiro N, Ohshima H

    The 53th Annual meeting of the Japanese Association for Oral Biology. Gifu, Japan  2011.9 

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    Presentation type：Poster presentation  

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  • Assessment of intermediate filament nestin and dentin sialoprotein expression patterns in the process of odontoblast differentiation.

    Quispe-Salcedo A, Ida-Yonemochi H, Nakatomi M, Kenmotsu S, Ohshima H

    The 116th Annual Meeting of the Japanese Association of Anatomists. Yokohama, Japan  2011.3 

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    Presentation type：Poster presentation  

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Awards

  • Postdoctoral Fellowship for Research in Japan

    2021   Japan Society for the Promotion of Science (JSPS)  

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  • Travel Grant for Young New Investigators. 98th IADR General Session – Washington DC. USA.

    2020   International Association for Dental Research (IADR)  

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  • STAR Network Academy Fellowship

    2019   International Association for Dental Research (IADR)  

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  • ravel Grant for Short-Term Research Stay in Niigata University, Japan

    2019   National Fund for Scientific Development, Technology and Technology Innovation (FONDECYT) – Peru  

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  • Swiss Government Excellence Scholarship for postdoctoral studies

    2017   Federal Commission for Scholarships (FCS)  

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  • Best paper award in the Journal of Oral Biosciences - 2015

    2015   Japanese Association for Oral Biology  

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  • Japanese government (Monbukagakusho) scholarship for research students.

    2010   Japanese Ministry of Education, Culture, Sports, Science and Technology  

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Research Projects

  • Homeostatic maintenance and activation of dental pulp quiescent stem/progenitor cells regulated by dendritic cells and macrophages

    Grant number：23H03078

    2023.4 - 2026.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\18980000 （ Direct Cost: \14600000 、 Indirect Cost：\4380000 ）

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  • Cross-talk among odontoblasts, dental pulp stem cells, and immune cells after exogenous injuries

    Grant number：22K21011

    2022.8 - 2024.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Research Activity Start-up

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\2860000 （ Direct Cost: \2200000 、 Indirect Cost：\660000 ）

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  • Cross-talk among odontoblasts, dental pulp stem cells, and immune cells after exogenous injuries

    Grant number：21F30412

    2021.7 - 2022.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for JSPS Fellows

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\2300000 （ Direct Cost: \2300000 ）

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  • 外的侵襲後の歯髄治癒過程における象牙芽細胞、歯髄幹細胞、免疫細胞間クロストーク

    Grant number：21F20412

    2021.4 - 2023.3

    System name：科学研究費助成事業

    Research category：特別研究員奨励費

    Awarding organization：日本学術振興会

    大島 勇人, QUISPE SALCEDO ANGELA

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    Grant amount：\2300000 （ Direct Cost: \2300000 ）

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Teaching Experience (researchmap)

  • Osteology

    2022.4

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  • Gross Anatomy

    2021.6
    Institution name：Niigata University, Faculty of Dentistry

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  • General and Oral Embryology

    2018
    -
    2021
    Institution name：Cientifica del Sur University (Lima, Peru)

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  • General and Oral Histology

    2018
    -
    2021
    Institution name：Cientifica del Sur University (Lima, Peru)

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Teaching Experience

  • 人体解剖学I

    2023
    Institution name：新潟大学

  • 人体解剖学実習

    2023
    Institution name：新潟大学

  • 人体解剖学II

    2023
    Institution name：新潟大学

 

Social Activities

  • Vice-president

    Role(s)： Presenter

    International Association for Dental Research – Peruvian Division  2019 - 2021

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  • Science Clubs Peru (Clubes de Ciencia Peru)

    Role(s)： Presenter

    2017

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Academic Activities

  • Associate Editor

    Revista Cientifica Odontologica (Lima)  2018

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    Type：Peer review 

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  • Review Editor

    Role(s)： Peer review

    Frontiers in Physiology  2017

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    Type：Peer review 

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  • Review Editor

    Role(s)： Peer review

    Frontiers in Dental Medicine 

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    Type：Peer review 

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