Updated on 2024/07/03

写真a

 
TASAKI Eisuke
 
Organization
Academic Assembly Institute of Science and Technology CHIKYU SEIBUTSU KAGAKU KEIRETU Associate Professor
Graduate School of Science and Technology Life and Food Sciences Associate Professor
Faculty of Science Department of Science Associate Professor
Title
Associate Professor
Homepage
https://etasaki0608.wixsite.com/website
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External link

Degree

  • Ph.D. ( 2017.9   Tottori University )

Research Interests

  • Social insect

  • Aging

  • 酸化ストレス

  • Antioxidant

  • Lifespan

  • Energy metabolism

  • Epigenetics

Research Areas

  • Life Science / Molecular biology

  • Life Science / Applied biochemistry  / 生体分子機能

  • Environmental Science/Agriculture Science / Insect science

  • Life Science / Animal physiological chemistry, physiology and behavioral biology

Research History (researchmap)

  • Niigata University   Academic Assembly Institute of Science and Technology CHIKYU SEIBUTSU KAGAKU KEIRETU   Associate Professor

    2024.6

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  • Niigata University   Graduate School of Science and Technology Life and Food Sciences   Associate Professor

    2024.6

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  • Niigata University   Faculty of Science   Associate Professor

    2024.6

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  • Niigata University   Faculty of Science   Assistant Professor

    2022.4 - 2024.6

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  • Niigata University   Graduate School of Science and Technology Life and Food Sciences   Assistant Professor

    2022.4 - 2024.6

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  • Niigata University   Academic Assembly Institute of Science and Technology CHIKYU SEIBUTSU KAGAKU KEIRETU   Assistant Professor

    2022.4 - 2024.6

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  • Kyoto University   Graduate School of Agriculture   Research Fellowships for Young Scientists (Postdoctoral Fellow, PD)

    2021.4 - 2022.3

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  • Kyoto University   Laboratory of Insect Ecology   PhD researcher

    2017.10 - 2021.3

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  • Tottori University   United Graduate School of Agricultural Sciences

    2014.4 - 2017.9

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Research History

  • Niigata University   Life and Food Sciences, Graduate School of Science and Technology   Associate Professor

    2024.6

  • Niigata University   Department of Science, Faculty of Science   Associate Professor

    2024.6

  • Niigata University   Institute of Science and Technology, Academic Assembly   Associate Professor

    2024.6

  • Niigata University   Life and Food Sciences, Graduate School of Science and Technology   Assistant Professor

    2022.4 - 2024.5

  • Niigata University   Institute of Science and Technology, Academic Assembly   Assistant Professor

    2022.4 - 2024.5

  • Niigata University   Faculty of Science   Assistant Professor

    2022.4 - 2024.5

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Professional Memberships

  • SOCIETY FOR FREE RADICAL RESEARCH JAPAN

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  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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  • JAPANESE SOCIETY OF APPLIED ENTOMOLOGY AND ZOOLOGY

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Papers

  • DESI-IMS coupled with triple quadrupole mass spectrometry demonstrated the capability of NMN imaging in Shelfordella lateralis tissue Reviewed

    Zinat Tamannaa, Takumi Sakamoto, Md. Al Mamun, Soho Oyama, A.S.M. Waliullah, Ariful Islam, Md. Mahamodun Nabi, Shuhei Aramaki, Eisuke Tasaki, Yuki Mitaka, Mamoru Takata, Tomohito Sato, Tomoaki Kahyo, Kenji Matsuura, Mitsutoshi Setou

    Medical Mass Spectrometry   8 ( 1 )   2024.6

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  • Cell type specific polyploidization in the royal fat body of termite queens Reviewed

    Tomonari Nozaki, Eisuke Tasaki, Kenji Matsuura

    Zoological Letters   2023.10

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s40851-023-00217-6

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  • A method for estimating colony size using queen fecundity in termites under field conditions Reviewed International journal

    Mamoru Takata, Kiyotaka Yabe, Takuya Noro, Shun Mizote, Takao Konishi, Eisuke Tasaki, Kenji Matsuura

    Science of Nature   110 ( 4 )   35 - 35   2023.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    Colony size in social insects is one of the most important factors in shaping their self-organized system. It affects a wide variety of traits such as foraging and defense strategies, social immune responses, the degree of polymorphism, and reproductive output. However, colony size estimation of subterranean termites in the field has been challenging, due to their extremely cryptic biology and multiple site-nesting behavior. Since natural selection favors workers that maximize the number of their siblings, the amount of egg production may reflect the number of workers in the colony. Here, we report a method for inferring colony size in the field using total egg production in each colony from a subterranean termite, Reticulitermes speratus. Our investigation of field colonies revealed that the body weight of queens reaches a peak and had the largest variance in June and July and accurately predicts the number of eggs laid by the queen per 24 h. Using laboratory-reared colonies, we found that the total egg production in each colony is proportional to the number of workers. We also estimated the colony size of 198 field colonies and found that the median and maximum colony size was 24,500 and 451,800 workers per colony. The method for inferring colony size presented here may also be applicable to termite species with a clear seasonality in egg production. The colony size estimate will contribute to understanding the life history strategies and social systems of termites.

    DOI： 10.1007/s00114-023-01865-6

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  • The royal food of termites shows king and queen specificity Reviewed

    Eisuke Tasaki, Yuki Mitaka, Yutaka Takahashi, A S M Waliullah, Zinat Tamannaa, Takumi Sakamoto, Ariful Islam, Masaki Kamiya, Tomohito Sato, Shuhei Aramaki, Kenji Kikushima, Makoto Horikawa, Katsumasa Nakamura, Tomoaki Kahyo, Mamoru Takata, Mitsutoshi Setou, Kenji Matsuura

    PNAS Nexus   2023.7

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    Society in eusocial insects is based on the reproductive division of labor, with a small number of reproductive individuals supported by a large number of non-reproductive individuals. Because inclusive fitness of all colony members depends on the survival and fertility of reproductive members, sterile members provide royals with special treatment. Here we show that termite kings and queens each receive special food of a different composition from workers. Sequential analysis of feeding processes demonstrated that workers exhibit discriminative trophallaxis, indicating their decision-making capacity in allocating food to the kings and queens. LC-MS/MS analyses of the stomodeal food and midgut contents revealed king- and queen-specific compounds including diacylglycerols and short-chain peptides. DESI-MSI analyses of 13C-labelled termites identified phosphatidylinositol and acetyl-L-carnitine in the royal food. Comparison of the digestive tract structure showed remarkable differences in the volume ratio of the midgut-to-hindgut among castes, indicating that digestive division of labor underlies reproductive division of labor. Our demonstration of king- and queen-specific food in termites provides insight into the nutritional system that underpins the extraordinary reproduction and longevity of royals in eusocial insects.

    DOI： 10.1093/pnasnexus/pgad222

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  • Plastic brain structure changes associated with the division of labour and ageing in termites Reviewed

    Tomoki Ishibashi, A S M Waliullah, Shuhei Aramaki, Masaki Kamiya, Tomoaki Kahyo, Katsumasa Nakamura, Eisuke Tasaki, Mamoru Takata, Mitsutoshi Setou, Kenji Matsuura

    Development, growth & differentiation   2023.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    Division of labour is a prominent feature of social insect societies, where different castes engage in different specialised tasks. As brain differences are associated with behavioural differences, brain anatomy may be linked to caste polymorphism. Here, we show that termite brain morphology changes markedly with caste differentiation and age in the termite, Reticulitermes speratus. Brain morphology was shown to be associated with reproductive division of labour, with reproductive individuals (alates and neotenic reproductives) having larger brains than non-reproductives (workers and soldiers). Micro-computed tomography (CT) imaging and dissection observations showed that the king's brain morphology changed markedly with shrinkage of the optic lobes during their long life in the dark. Behavioural experiments showed that mature primary kings lose visual function as a result of optic lobe shrinkage. These results suggested that termites restructure their nervous systems to perform necessary tasks as they undergo caste differentiation, and that they also show flexible changes in brain morphology even after the final moult. This study showed that brain morphology in social insects is linked to caste and ageing, and that the evolution of the division of labour is underpinned by the development of diverse neural systems for specialised tasks. This article is protected by copyright. All rights reserved.

    DOI： 10.1111/dgd.12873

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  • Higher levels of the lipophilic antioxidants coenzyme Q10 and vitamin E in long-lived termite queens than in short-lived workers Reviewed

    Eisuke Tasaki, Yorihiro Yamamoto, Yoshihito Iuchi

    Insect Science   2023.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1744-7917.13217

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  • Discovery of an underground chamber to protect kings and queens during winter in temperate termites Reviewed

    Mamoru Takata, Takao Konishi, Shuya Nagai, Yao Wu, Tomonari Nozaki, Eisuke Tasaki, Kenji Matsuura

    Scientific Reports   13   8809 - 8809   2023.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-023-36035-1

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  • Heritable effects on caste determination and colony-level sex allocation in termites under field conditions Reviewed

    Mamoru Takata, Shuya Nagai, Tatsuya Inagaki, Yusaku Ohkubo, Eisuke Tasaki, Kenji Matsuura

    iScience   26 ( 3 )   106207 - 106207   2023.3

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.isci.2023.106207

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  • King- and queen-specific degradation of uric acid contributes to reproduction in termites Reviewed

    Takao Konishi, Eisuke Tasaki, Mamoru Takata, Kenji Matsuura

    Proceedings of the Royal Society B: Biological Sciences   290 ( 1990 )   2023.1

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    Publishing type：Research paper (scientific journal)   Publisher：The Royal Society  

    Caste-based reproductive division of labour in social insects is built on asymmetries in resource allocation within colonies. Kings and queens dominantly consume limited resources for reproduction, while non-reproductive castes such as workers and soldiers help reproductive castes. Studying the regulation of such asymmetries in resource allocation is crucial for understanding the maintenance of sociality in insects, although the molecular background is poorly understood. We focused on uric acid, which is reserved and used as a valuable nitrogen source in wood-eating termites. We found that king- and queen-specific degradation of uric acid contributes to reproduction in the subterranean termite Reticulitermes speratus . The urate oxidase gene ( RsUAOX ), which catalyses the first step of nitrogen recycling from stored uric acid, was highly expressed in mature kings and queens, and upregulated with differentiation into neotenic kings/queens. Suppression of uric acid degradation decreased the number of eggs laid per queen. Uric acid was shown to be provided by workers to reproductive castes. Our results suggest that the capacity to use nitrogen, which is essential for the protein synthesis required for reproduction, maintains colony cohesion expressed as the reproductive monopoly held by kings and queens.

    DOI： 10.1098/rspb.2022.1942

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    Other Link： https://royalsocietypublishing.org/doi/full-xml/10.1098/rspb.2022.1942

  • Why and how do termite kings and queens live so long? Reviewed

    Eisuke Tasaki, Mamoru Takata, Kenji Matsuura

    Philosophical Transactions of the Royal Society B: Biological Sciences   376 ( 1823 )   20190740 - 20190740   2021.4

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：The Royal Society  

    Lifespan varies greatly across the tree of life. Of the various explanations for this phenomenon, those that involve trade-offs between reproduction and longevity have gained considerable support. There is an important exception: social insect reproductives (queens and in termites, also kings) exhibit both high reproductive outputs and extraordinarily long lives. As both the ultimate and proximate mechanisms underlying the absence of the fecundity/longevity trade-off could shed light on the unexpected dynamics and molecular mechanisms of extended longevity, reproductives of social insects have attracted much attention in the field of ageing research. Here, we highlight current ecological and physiological studies on ageing and discuss the various possible evolutionary and molecular explanations of the extended lifespans of termite reproductives. We integrate these findings into a coherent framework revealing the evolution of longevity in these reproductives. Studies on termites may explain why and how ageing is shaped by natural selection.


    This article is part of the theme issue ‘Ageing and sociality: why, when and how does sociality change ageing patterns?’

    DOI： 10.1098/rstb.2019.0740

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    Other Link： https://royalsocietypublishing.org/doi/full-xml/10.1098/rstb.2019.0740

  • Insect feces tea of locust (<i>Locusta migratoria</i>) suppresses lipid accumulation in 3T3-L1 cells and mice Reviewed

    Takahashi Yushi, Kuribayashi Hiromi, Tasaki Eisuke, Yoshida Izumi, Ide Masahiro, Fujita Kazuhiro, Igarashi Tomoji, Saeki Shinjiro, Iuchi Yoshihito

    Food Science and Technology Research   27 ( 5 )   807 - 816   2021

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    Language：English   Publisher：Japanese Society for Food Science and Technology  

    <p>Insect feces tea has been used as traditional Chinese medicine. Obesity is one of the main factors of lifestyle diseases, so prevention and improvement of obesity are indispensable for living a healthy life in modern society. We examined the lipid accumulation-suppressing effect of tea from <i>Locusta migratoria</i> (LT) <i>in vitro</i> and <i>in vivo</i> assays. LT suppressed the differentiation of 3T3-L1 cells to adipocytes, but not the process of accumulation of lipid droplets. Furthermore, it suppressed the expression of peroxisome proliferator-activated receptor (PPAR)γ and CCAAT/enhancer-binding protein <i>(C/EBP)</i>α, master regulators of differentiation. In mice fed a high-fat diet and administered with LT, the body weight did not change compared to the mice fed with water; however, the white fat weight, particularly the visceral fat, was reduced significantly. These results indicated the potential of LT to suppress fat accumulation by inhibiting adipocyte differentiation.</p>

    DOI： 10.3136/fstr.27.807

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  • A non-invasive method for sexing first and second instar larvae of termites using external morphology Reviewed

    Mamoru Takata, Tatsuya Inagaki, Tomoki Ishibashi, Eisuke Tasaki, Kenji Matsuura

    Insectes Sociaux   67 ( 4 )   487 - 493   2020.9

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1007/s00040-020-00785-2

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    Other Link： http://link.springer.com/article/10.1007/s00040-020-00785-2/fulltext.html

  • Reproduction deep inside wood: a low O2 and high CO2 environment promotes egg production by termite queens Reviewed

    Eisuke Tasaki, Yasuyuki Komagata, Tatsuya Inagaki, Kenji Matsuura

    Biology Letters   2020.4

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1098/rsbl.2020.0049

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  • Transcriptomic analysis of epigenetic modification genes in the termite Reticulitermes speratus Reviewed

    Yuki Mitaka, Eisuke Tasaki, Tomonari Nozaki, Taro Fuchikawa, Kazuya Kobayashi, Kenji Matsuura

    Insect Science   27 ( 2 )   202 - 211   2018.10

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/1744-7917.12640

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  • High expression of the breast cancer susceptibility gene BRCA1 in long-lived termite kings Reviewed

    Eisuke Tasaki, Yuki Mitaka, Tomonari Nozaki, Kazuya Kobayashi, Kenji Matsuura, Yoshihito Iuchi

    Aging   10 ( 10 )   2668 - 2683   2018.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Impact Journals, LLC  

    DOI： 10.18632/aging.101578

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  • Long-Lived Termite Queens Exhibit High Cu/Zn-Superoxide Dismutase Activity Reviewed

    Eisuke Tasaki, Kazuya Kobayash, Kenji Matsuura, Yoshihito Iuchi

    Oxidative Medicine and Cellular Longevity   2018   1   2018

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    Authorship：Lead author   Publisher：Hindawi Limited  

    DOI： 10.1155/2018/5127251

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  • Hypoxia adaptation in termites: hypoxic conditions enhance survival and reproductive activity in royals Reviewed

    Eisuke Tasaki, Kenji Matsuura, Yoshihito Iuchi

    Insect Molecular Biology   27 ( 6 )   2018

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/imb.12519

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  • Uric acid, an important antioxidant contributing to survival in termites Reviewed

    Eisuke Tasaki, Hiroki Sakurai, Masaru Nitao, Kenji Matsuura, Yoshihito Iuchi

    PLOS ONE   12 ( 6 )   e0179426   2017.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：PUBLIC LIBRARY SCIENCE  

    Reactive oxygen species (ROS) are generated spontaneously in all organisms and cause oxidative damage to biomolecules when present in excess. Accumulated oxidative damage accelerates aging; enhanced antioxidant capacity may be a positive factor for longevity. Recently, numerous studies of aging and longevity have been performed using short-lived animals, however, longevity mechanisms remain unknown. Here we show that a termite Reticulitermes speratus that is thought to be long-lived eusocial insect than other solitary insects uses large quantities of uric acid as an antioxidant against ROS. We demonstrated that the accumulation of uric acid considerably increases the free radical-scavenging activity and resistance against ultraviolet-induced oxidative stress in laboratory-maintained termites. In addition, we found that externally administered uric acid aided termite survival under highly oxidative conditions. The present data demonstrates that in addition to nutritional and metabolic roles, uric acid is an essential antioxidant for survival and contributes significantly to longevity. Uric acid also plays important roles in primates but causes gout when present in excess in humans. Further longevity studies of long-lived organisms may provide important breakthroughs with human health applications.

    DOI： 10.1371/journal.pone.0179426

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    Other Link： http://orcid.org/0000-0002-6514-5134

  • Protective role of testis-specific peroxiredoxin 4 against cellular oxidative stress Reviewed

    Eisuke Tasaki, Shotaro Matsumoto, Hisashi Tada, Toshihiro Kurahashi, Xuhong Zhang, Junichi Fujii, Toshihiko Utsumi, Yoshihito Iuchi

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   60 ( 3 )   156 - 161   2017.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION  

    Peroxiredoxin (PRDX), a newly discovered antioxidant enzyme, has an important role in hydrogen peroxide reduction. Among six PRDX genes (PRDX1-6) in mammals, PRDX4 gene is alternatively spliced to produce the somatic cell form (PRDX4) and the testis specific form (PRDX4t). In our previous study, PRDX4 knockout mice displayed testicular atrophy with an increase in cell death due to oxidative stress. However, the antioxidant function of PRDX4t is unknown. In this study, we demonstrate that PRDX4t plays a protective role against oxidative stress in the mammalian cell line HEK293T. The PRDX4t-EGFP plasmid was transferred into HEK293T cells; protein expression was confirmed in the cytoplasm. To determine the protective role of PRDX4t in cells, we performed image-based analysis of PRDX4t-EGFP expressed cells exposed to UV irradiation and hydrogen peroxide using fluorescent probe CelIROX. Our results suggested that PRDX4t-EGFP expressed cells had reduced levels of oxidative stress compared with cells that express only EGFP. This study highlights that PRDX4t plays an important role in cellular antioxidant defense.

    DOI： 10.3164/jcbn.16-96

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    Other Link： http://orcid.org/0000-0002-6514-5134

  • An Efficient Antioxidant System in a Long-Lived Termite Queen Reviewed

    Eisuke Tasaki, Kazuya Kobayashi, Kenji Matsuura, Yoshihito Iuchi

    PLOS ONE   12 ( 1 )   e0167412   2017.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：PUBLIC LIBRARY SCIENCE  

    The trade-off between reproduction and longevity is known in wide variety of animals. Social insect queens are rare organisms that can achieve a long lifespan without sacrificing fecundity. The extended longevity of social insect queens, which contradicts the trade-off, has attracted much attention because it implies the existence of an extraordinary anti-aging mechanism. Here, we show that queens of the termite Reticulitermes speratus incur significantly lower oxidative damage to DNA, protein and lipid and have higher activity of antioxidant enzymes than non-reproductive individuals (workers and soldiers). The levels of 8-hydroxy-2'-deoxyguanosine (oxidative damage marker of DNA) were lower in queens than in workers after UV irradiation. Queens also showed lower levels of protein carbonyls and malondialdehyde (oxidative damage markers of protein and lipid, respectively). The antioxidant enzymes of insects are generally composed of catalase (CAT) and peroxiredoxin (Prx). Queens showed more than two times higher CAT activity and more than seven times higher expression levels of the CAT gene RsCAT1 than workers. The CAT activity of termite queens was also markedly higher in comparison with other solitary insects and the queens of eusocial Hymenoptera. In addition, queens showed higher expression levels of the Prx gene RsPRX6. These results suggested that this efficient antioxidant system can partly explain why termite queens achieve long life. This study provides important insights into the evolutionary linkage of reproductive division of labor and the development of queens' oxidative stress resistance in social insects.

    DOI： 10.1371/journal.pone.0167412

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    Other Link： http://orcid.org/0000-0002-6514-5134

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MISC

  • 長寿命生物モデルに見出された新規抗酸化酵素の機能解析

    田崎 英祐

    ストレス科学研究   37   74 - 76   2023.10

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    Language：Japanese   Publisher：(公財)パブリックヘルスリサーチセンター  

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  • Kings’ aging influences offspring offspring’s caste fate through epigenetic inheritance in termites

    高橋迪彦, 高田守, 石橋朋樹, 田崎英祐, RUEPPELL Olav, VARGO Edward L., 松浦健二

    日本進化学会大会プログラム・講演要旨集(Web)   25th   2023

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  • ブロイラー雛の成長及び飼料摂取量におけるオオシロアリ(Hodotermopsis sjostedti)粉末添加の効果

    塚原洋子, 友永奈美, 田崎英祐, 三高雄希, 友永省三, 熊谷元, 広岡博之, 松浦健二

    関西畜産学会報   ( 180 )   2023

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  • トノサマバッタフン茶のメタボリックシンドローム抑制効果

    高橋 有志, 栗林 宏美, 田崎 英祐, 吉田 泉, 井出 将博, 藤田 和弘, 五十嵐 友二, 佐伯 真二郎, 井内 良仁

    日本生化学会大会プログラム・講演要旨集   95回   3P - 276   2022.11

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    Language：Japanese   Publisher：(公社)日本生化学会  

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  • シロアリにおける繁殖分業に基づいた社会集団レベルの尿酸代謝システム

    小西堯生, 田崎英祐, 高田守, 松浦健二

    日本応用動物昆虫学会大会講演要旨   66th   2022

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  • 尿酸代謝調節に着目した超長寿命昆虫ヤマトシロアリの生存戦略の解析

    梶原由貴, 木村洋貴, 中筋勇希, 藤崎翼, 田崎英祐, 井内良仁

    日本農芸化学会中四国支部講演会講演要旨集(Web)   62nd   2022

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  • 超長寿命昆虫ヤマトシロアリの抗酸化代謝調節

    梶原由貴, 中筋勇希, 木村洋貴, 藤崎翼, 田崎英祐, 井内良仁

    日本酸化ストレス学会学術集会プログラム・抄録集   75th (CD-ROM)   2022

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  • 養鶏飼料におけるタンパク源の代替としてのシロアリの可能性

    塚原洋子, 友永奈美, 田崎英祐, 三高雄希, 友永省三, 熊谷元, 広岡博之, 松浦健二

    日本畜産学会大会講演要旨   130th   2022

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  • Functional analysis of antioxidant enzymes specific to the long-lived termite king and queen

    田崎英祐

    日本分子生物学会年会プログラム・要旨集(Web)   45th   2022

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  • 親が決めるシロアリの分化運命とコロニーレベルでの性投資比

    高田守, 永井秀弥, 稲垣辰哉, 大久保祐作, 田崎英祐, 松浦健二

    日本動物行動学会大会発表要旨集   40th (CD-ROM)   2021

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  • 尿酸に注目したヤマトシロアリ長寿命の解析

    梶原由貴, 中筋勇希, 木村洋貴, 有本隼人, 田崎英祐, 井内良仁

    日本酸化ストレス学会学術集会プログラム・抄録集   74th (CD-ROM)   2021

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  • 超長寿命昆虫ヤマトシロアリの代謝変換による尿酸合成亢進

    梶原由貴, 中筋勇希, 木村洋貴, 田崎英祐, 井内良仁

    日本生化学会大会(Web)   94th   [P - 352]   2021

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    Language：Japanese   Publisher：(公社)日本生化学会  

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  • The end of colony: termite workers steal nitrogen source under king-absent condition

    小西堯生, 田崎英祐, 松浦健二

    日本応用動物昆虫学会大会講演要旨   65th   2021

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  • 社会性昆虫の個体を超えた代謝ネットワーク研究に挑む

    田崎英祐, 田崎英祐, 井内良仁, 井内良仁, 松浦健二

    日本応用動物昆虫学会大会講演要旨   65th   2021

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  • Long Longevity and Antioxidant System in Queens of The Subterranean Termite Reticulitermes speratus Invited

    Eisuke Tasaki

    Termite journal   173 ( 173 )   12 - 16   2020.1

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    Authorship：Lead author,　Corresponding author   Language：Japanese  

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  • 男女共同参画社会の性役割分業:体格の性差で決まる兵隊シロアリの性比

    高田守, CHEN Jiaming, YAO Wu, 田崎英祐, 松浦健二

    日本動物行動学会大会発表要旨集   39th (CD-ROM)   2020

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  • シロアリ王の活動的長寿を支えるロイヤルフードの特定と機能解析

    田崎英祐

    三島海雲記念財団研究報告書(CD-ROM)   ( 56 )   2019

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  • Queens in conflict: clonal drive in secondary queen population of AQS termite

    呉瑶, 高田守, 田崎英祐, 松浦健二

    個体群生態学会大会プログラム・講演要旨集(Web)   35th   2019

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  • 息子の将来とオヤジの背中:王の成熟度で決まるシロアリの羽アリ性比

    高田守, 永井秀弥, 稲垣辰哉, 田崎英祐, 松浦健二

    日本動物行動学会大会発表要旨集   38th   2019

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  • 高い生産性の維持を実現するシロアリの王と女王のエネルギー代謝機構

    田崎英祐, 三高雄希, 小林和也, 井内良仁, 松浦健二

    日本分子生物学会年会プログラム・要旨集(Web)   42nd   2019

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  • ヤマトシロアリにおけるエピジェネティック修飾関連遺伝子の王・女王特異的発現

    三高雄希, 田崎英祐, 野崎友成, 渕側太郎, 小林和也, 松浦健二

    日本分子生物学会年会プログラム・要旨集(Web)   42nd   2019

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  • シロアリの王の活動的長寿を実現するDNA修復関連遺伝子の特定

    田崎英祐, 三高雄希, 野崎友成, 小林和也, 井内良仁, 松浦健二

    日本応用動物昆虫学会大会講演要旨   63rd   2019

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  • Longevity and antioxidant defenses in termite

    田崎 英祐

    昆虫と自然   53 ( 2 )   21 - 24,図巻頭1p   2018.2

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  • 長寿昆虫シロアリ女王の優れた抗酸化システム

    田崎英祐, 小林和也, 松浦健二, 井内良仁

    日本酸化ストレス学会学術集会プログラム・抄録集   71st   2018

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  • 長寿かつ多産を実現する抗酸化システム:シロアリの女王特異的に発現するカタラーゼの機能解析

    田崎英祐, 田崎英祐, 松浦健二, 井内良仁, 井内良仁

    日本分子生物学会年会プログラム・要旨集(Web)   41st   2018

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  • 昆虫食のメタボリックシンドローム改善効果

    井内良仁, 栗林宏美, 藤田晃大, 柿薗博美, 田崎英祐, 佐伯真二郎

    日本生化学会大会(Web)   90th   2017

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  • 真社会性昆虫ヤマトシロアリの長寿命分子メカニズムの解明に挑む

    田崎英祐, 田崎英祐, 小林和也, 松浦健二, 井内良仁, 井内良仁

    日本生化学会大会(Web)   90th   2017

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  • アンチエイジングをめざす-新しい食品機能性評価系の提案-

    田崎英祐, 井内良仁, 井内良仁

    New Food Industry   58 ( 1 )   23 - 28   2016.1

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    Language：Japanese   Publisher：食品資材研究会  

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  • 真社会性昆虫ヤマトシロアリ生殖虫の長寿命を支える生体分子恒常性機能

    田崎英祐, 田崎英祐, 田中友貴, 三岳千夏, 小林和也, 末広亘, 松浦健二, 井内良仁, 井内良仁

    日本応用動物昆虫学会大会講演要旨   60th   2016

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  • 長寿命昆虫ヤマトシロアリの代謝制御能力

    田崎英祐, 田崎英祐, 末広亘, 松浦健二, 井内良仁, 井内良仁

    日本応用動物昆虫学会大会講演要旨   60th   2016

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  • 長寿命昆虫シロアリの生体分子恒常性維持機能の評価

    田崎英祐, 田崎英祐, 田中友貴, 三岳千夏, 小林和也, 末広亘, 松浦健二, 井内良仁, 井内良仁, 井内良仁

    日本分子生物学会年会プログラム・要旨集(Web)   39th   2016

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  • 昆虫食の食品機能性

    井内良仁, 井内良仁, 藤田晃大, 柿薗博美, 佐伯真二郎, 田崎英祐

    日本酸化ストレス学会学術集会プログラム・抄録集   69th   2016

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  • 社会性昆虫ヤマトシロアリの長寿命を可能にする代謝調節

    井内良仁, 井内良仁, 田崎英祐, 田崎英祐, 櫻井宏樹, 仁田尾優, 松浦健二

    日本酸化ストレス学会学術集会プログラム・抄録集   68th   2015

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  • 昆虫食の機能性評価

    井内良仁, 藤田晃大, 柿薗博美, 佐伯真二郎, 田崎英祐

    日本生化学会大会(Web)   88th   [3P0567] - [3P0567]   2015

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  • ヤマトシロアリの高い抗酸化能と尿酸の機能

    櫻井宏樹, 田崎英祐, 田崎英祐, 仁田尾優, 松浦健二, 井内良仁, 井内良仁

    日本応用動物昆虫学会大会講演要旨   59th   2015

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  • 真社会性昆虫ヤマトシロアリのカースト間における抗酸化能評価と長寿命の関係

    田崎英祐, 田中友貴, 小林和也, 末広亘, 松浦健二, 井内良仁

    日本生化学会大会(Web)   88th   [1P1340] - [1P1340]   2015

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  • ヤマトシロアリの尿酸を利用した抗酸化システム

    田崎英祐, 田崎英祐, 櫻井宏樹, 仁田尾優, 松浦健二, 井内良仁, 井内良仁

    日本応用動物昆虫学会大会講演要旨   59th   2015

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  • 真社会性昆虫ヤマトシロアリの長寿命を可能にした戦略

    田崎英祐, 末広亘, 松浦健二, 松井健二, 真野純一, 井内良仁, 井内良仁

    日本分子生物学会年会プログラム・要旨集(Web)   37th   2014

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  • ヤマトシロアリの長寿命に関与する尿酸

    井内良仁, 田崎英祐, 櫻井宏樹, 仁田尾優, 松浦健二

    日本酸化ストレス学会学術集会プログラム・抄録集   67th   2014

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  • 抗酸化酵素ペルオキシレドキシン4bの機能解析

    松本勝太郎, 多田久志, 田崎英祐, 倉橋敏裕, 張旭紅, 藤井順逸, 井内良仁

    日本分子生物学会年会プログラム・要旨集(Web)   37th   2014

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  • 長寿命昆虫ヤマトシロアリの抗酸化システムにおける尿酸の役割

    田崎英祐, 櫻井宏樹, 仁田尾優, 藤田晃大, 松浦健二, 井内良仁

    日本分子生物学会年会プログラム・要旨集(Web)   36th   2013

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  • 代謝に注目したシロアリの長寿命の解析

    田崎英祐, 山本結花, 末広亘, 松浦健二, 井内良仁

    日本分子生物学会年会プログラム・要旨集(Web)   36th   2013

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  • ヤマトシロアリ(Reticulitermes speratus)兵隊アリに新規に見出された抗酸化物質

    田崎英祐, 仁田尾優, 赤壁義彦, 松井健二, 井内良仁

    日本農芸化学会大会講演要旨集(Web)   2013   2013

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  • ヤマトシロアリの高い抗酸化能を担う物質としての尿酸

    櫻井宏樹, 田崎英祐, 仁田尾優, 松井健二, 赤壁義彦, 松浦健二, 井内良仁

    日本分子生物学会年会プログラム・要旨集(Web)   36th   2013

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  • ヤマトシロアリ兵隊アリが有する抗酸化物質の単離・同定の試み

    田崎英祐, 赤壁義彦, 井内良仁

    日本農芸化学会中四国支部講演会講演要旨集   34th   2012

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  • 抗酸化システムに注目したシロアリの長寿命の解析

    田崎英祐, 山本結花, 末広亘, 松浦健二, 井内良仁

    日本分子生物学会年会プログラム・要旨集(Web)   35th   2012

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Awards

  • 優秀ポスター賞

    2018.5   日本酸化ストレス学会  

    田﨑 英祐

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  • 優秀ポスター賞

    2017.7   日本分子病理研究会  

    田﨑 英祐

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  • 優秀ポスター賞

    2016.11   日本分子生物学会  

    田﨑 英祐

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  • 最優秀賞

    2015.11   未来博士３分間コンペティション2015  

    田﨑 英祐

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  • オーディエンス銀賞

    2015.11   未来博士３分間コンペティション2015  

    田﨑 英祐

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Research Projects

  • Longevity engineering: Mechanisms underlying active longevity in the extremely long-lived organisms

    Grant number：23H00332

    2023.4 - 2028.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (A)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\46670000 （ Direct Cost: \35900000 、 Indirect Cost：\10770000 ）

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  • 長寿命生物モデルに見出された新規抗酸化酵素の寿命制御機構の解明

    Grant number：22K14830

    2022.4 - 2025.3

    System name：科学研究費助成事業 若手研究

    Research category：若手研究

    Awarding organization：日本学術振興会

    田崎 英祐

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • 社会性昆虫における繁殖個体の多産と長寿を支える代謝分業システムの解明

    Grant number：21J01351

    2021.4 - 2022.3

    System name：科学研究費助成事業 特別研究員奨励費

    Research category：特別研究員奨励費

    Awarding organization：日本学術振興会

    田崎 英祐

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    Grant amount：\3640000 （ Direct Cost: \2800000 、 Indirect Cost：\840000 ）

    1. 代謝負荷の評価： シロアリの繁殖個体を用いた試験を行うために、まず京都・滋賀のフィールドから成熟した王と女王が存在するヤマトシロアリのコロニーを十分量採集し、試験に用いるまで安定な実験室条件下で維持管理した。彼らの代謝負荷を評価するため、同数のワーカーに対して供与する女王の数を変えた複数の処理区を用意し、一定飼育期間後ワーカーの生存率および体重、生体分子酸化傷害量（マロンジアルデヒド量）を求めた。その結果、供与した女王の数はワーカーの生存率に負の効果をもつことを明らかにした。一方で、生体分子酸化傷害量に処理区間の差はなかった。これらの結果は、シロアリにおける代謝負荷の存在を示唆するとともに、代謝負荷が酸化傷害を伴わない可能性あるいは酸化傷害の標的分子がマロンジアルデヒドではない可能性を示す。
    2. 代謝経路の推定： 繁殖に要求されるシロアリのワーカーと王、女王の代謝経路（中心炭素代謝経路）を明らかにするため、２つのオミクス解析を行なった。まず、ヤマトシロアリのRNA-seqデータを用いて、中心炭素代謝経路を構成する(i)解糖系と(ii)ペントースリン酸経路、(iii)TCA回路の遺伝子発現量をカースト間で比較解析した。さらに、ガスクロマトグラフィー質量分析装置（GC-MS）を用いたヤマトシロアリのメタボローム解析を行い、カースト間における代謝成分量を比較解析した。その結果、ヤマトシロアリのカースト間における代謝経路が大きく異なることを明らかにし、特に女王で特異な代謝経路を特定した。

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Teaching Experience

  • 自然環境科学総論

    2023
    Institution name：新潟大学

  • 自然環境科学研究演習

    2023
    Institution name：新潟大学

  • 学問の扉 知と方法の最前線

    2023
    Institution name：新潟大学

  • 課題研究II(生物学)

    2023
    Institution name：新潟大学

  • 課題研究(自然環境)B

    2023
    Institution name：新潟大学

  • 課題研究I(生物学)

    2023
    Institution name：新潟大学

  • 生物化学演習

    2023
    Institution name：新潟大学

  • 生物学総合演習

    2023
    Institution name：新潟大学

  • 生物学実習I

    2023
    Institution name：新潟大学

  • 環境生物学演習

    2022
    Institution name：新潟大学

  • 自然環境科学実験B1

    2022
    Institution name：新潟大学

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