Updated on 2025/08/03

写真a

 
IKAMI Yasuhiro
 
Organization
University Medical and Dental Hospital Cardiovascular Medicine Assistant Professor
Title
Assistant Professor
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Degree

  • 博士（医学） ( 2022.9 )

Research Areas

  • Life Science / Cardiology  / 不整脈

Research History (researchmap)

  • Niigata University   Medical and Dental Hospital Cardiovascular Medicine

    2023.4

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  • 新潟県立新発田病院   循環器内科

    2022.10 - 2023.3

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  • 新潟県厚生連新潟医療センター   循環器内科

    2022.4 - 2022.9

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  • Niigata University   Medical and Dental Hospital Cardiovascular Medicine

    2017.4 - 2022.3

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Research History

  • Niigata University   Cardiovascular Medicine, University Medical and Dental Hospital   Assistant Professor

    2023.4

Education

  • Niigata University   Graduate School of Medical and Dental Sciences   Course of Biological Functions and Medical Control

    2018.4 - 2022.9

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    Country： Japan

    Notes： Department of Cardiovascular Medicine

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  • Niigata University   Faculty of Medicine   School of Medicine

    2007.4 - 2013.3

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    Country： Japan

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Qualification acquired

  • Doctor

 

Papers

  • Relation between resting amygdala activity and cardiovascular events in patients with cardiac sarcoidosis

    Sou Otsuki, Masahiro Hatakeyama, Atsushi Michael Kimura, Kosei Nakamura, Mikhail Ratanov, Rie Akagawa, Hironori Furuse, Naomasa Suzuki, Yasuhiro Ikami, Yuki Hasegawa, Masaomi Chinushi, Hitoshi Shimada, Takayuki Inomata

    European Journal of Nuclear Medicine and Molecular Imaging   2025.4

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Purpose

    Previous studies indicate amygdala activity (AmygA) measured by FDG-positron emission tomography (PET) predicts the risk of subsequent cardiovascular events. However, AmygA measurement use for predicting the prognosis of patients with cardiac sarcoidosis (CS) is unknown. We aimed to investigate the association between AmygA and cardiovascular events in patients with CS.

    Methods

    Consecutive 40 patients with CS who underwent FDG-PET were identified retrospectively. Cardiovascular events included ventricular tachyarrhythmias and heart failure hospitalizations. We examined the association between AmygA and cardiovascular events and investigated the timing of FDG-PET influence on AmygA measurements.

    Results

    During a follow-up of 4.5 (2.5–7.7) years, 14 (35%) patients experienced cardiovascular events. Left-AmygA was a stronger cardiovascular event predictor than the Right-AmygA, and incidences were significantly higher in the high left-AmygA group than low group (log-rank P = 0.018). Multivariable analysis revealed left-AmygA augmentation (hazard ratio [HR]: 1.76 per 0.1 increase, 95% confidence interval [CI]: 1.12–2.87, P = 0.016) was the only independent predictor of cardiovascular event. Among the 40 patients, 32 underwent multiple PET-scans. No significant difference was found between the AmygA value on the first PET-scan and the mean on multiple PET scans, and the correlation coefficient was 0.93 (P < 0.001). Multivariate analyses revealed the mean left-AmygA value was the only independent predictor of cardiovascular event (P = 0.011).

    Conclusions

    High left-AmygA was associated with the higher rates of cardiovascular events in patients with CS. AmygA would be a prognostic biomarker regardless of the PET-scan timing.

    DOI： 10.1007/s00259-025-07266-3

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    Other Link： https://link.springer.com/article/10.1007/s00259-025-07266-3/fulltext.html

  • Lesion characteristics of long application time ablation using unipolar half-normal saline irrigation and bipolar normal saline irrigation. International journal

    Takumi Kasai, Osamu Saitoh, Ayaka Oikawa, Naomasa Suzuki, Yasuhiro Ikami, Yuki Hasegawa, Sou Otsuki, Takayuki Inomata, Hiroshi Furushima, Masaomi Chinushi

    Indian pacing and electrophysiology journal   2024.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Unipolar radiofrequency (RF) ablation using half-normal saline irrigation (UNIP-HNS) and bipolar RF ablation using normal saline irrigation (BIP-NS) are effective to treat arrhythmias from inside thick myocardium. However, differences between these two ablations when using a long application time had not fully been studied. METHODS: UNIP-HNS, BIP-NS and unipolar RF ablation using normal saline irrigation (UNIP-NS) were applied for 120 seconds (30 W and 20-g contact) to porcine endocardial wall (≧15.0 mm thickness). RESULTS: All ablations (30 applications each in UNIP-HNS and BIP-NS, and 20 applications in UNIP-NS) were successfully accomplished without steam-pop. Total impedance decline was largest in BIP-NS followed by UNIP-HNS and UNIP-NS. UNIP-HNS created larger surface lesions and greater maximum lesion width under the surface than those by UNIP-NS and BIP-NS. Endocardial lesion depth in UNIP-HNS and BIP-NS were deeper than that in UNIP-NS, but with no difference between UNIP-HNS and BIP-NS, when selecting non-transmural lesions. Similar results were obtained when all lesions (non-transmural and transmural) were included and endocardial lesion depth of the transmural lesions (13/30 applications of BIP-NS) was estimated as 50% of the myocardial thickness. Lesion length in the transverse myocardial wall (endocardial plus epicardial lesions) was greatest in BIP-NS. CONCLUSIONS: Longer application time ablation (30 W) targeting the thick myocardium was performable in UNIP-HNS and BIP-NS. Since a transmural lesion and/or a deeper lesion into the myocardial wall are created, BIP-NS is preferable if two ablation catheters can be positioned on either side of the target.

    DOI： 10.1016/j.ipej.2024.11.003

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  • Differences in coagulation responses to vascular injury between uninterrupted dabigatran and apixaban: A clinical prospective randomized study. International journal

    Yasuhiro Ikami, Daisuke Izumi, Shinya Fujiki, Hirotaka Sugiura, Sou Otsuki, Naomasa Suzuki, Yuta Sakaguchi, Takahiro Hakamata, Yuki Hasegawa, Nobue Yagihara, Kenichi Iijima, Takahiro Tanaka, Masahiro Ishizawa, Masaomi Chinushi, Tohru Minamino, Takayuki Inomata

    Heart rhythm   2024.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: The coagulation response during vascular injury with uninterrupted administration of direct oral anticoagulants has not been elucidated. OBJECTIVE: Our aim was to evaluate differences in coagulation responses after vascular injury between uninterrupted direct thrombin inhibitor and direct factor Xa inhibitor recipients. METHODS: Patients scheduled for catheter ablation for atrial fibrillation were randomly assigned to receive dabigatran or apixaban in this prospective, randomized, comparative, parallel-group study. Venous blood was collected 3 times: 180 minutes after taking the anticoagulant on the day before the procedure, before vascular punctures of the ablation procedure, and 10-15 minutes after the start of vascular punctures. RESULTS: Forty-two patients were enrolled. The prothrombin fragment 1+2 level, the primary end point, was much larger after vascular puncture in the uninterrupted dabigatran recipients (median, 83 pmol/L; interquartile range, 56-133 pmol/L) than in the uninterrupted apixaban recipients (median, 1 pmol/L; interquartile range, -3 to 19 pmol/L; P < .001). Antithrombin levels decreased after vascular puncture in dabigatran recipients, and both protein C and antithrombin levels decreased after vascular puncture in apixaban recipients. CONCLUSION: Unlike uninterrupted apixaban, uninterrupted dabigatran does not inhibit thrombin generation in response to vascular injury.

    DOI： 10.1016/j.hrthm.2024.07.017

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  • Predictors of long-term survival in Japanese patients with heart failure with reduced ejection fraction (HFrEF) treated with cardiac resynchronization therapy-defibrillators (CRT-D). International journal

    Yuta Sakaguchi, Daisuke Izumi, Rhythm Wada, Rie Akagawa, Naomasa Suzuki, Takahiro Hakamata, Yasuhiro Ikami, Yuki Hasegaw, Sou Otsuki, Nobue Yagihara, Kenichi Iijima, Takayuki Inomata

    Pacing and clinical electrophysiology : PACE   46 ( 12 )   1484 - 1490   2023.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Reports on the factors predicting long-term survival of CRT-D cases from Western countries are increasing, however, those from Asia including Japan are still sparse. We aimed to clarify the factors predicting long-term survival of Japanese CRT-D cases. METHODS: We retrospectively analyzed consecutive 133 patients who underwent CRT-D implantation between 2006 and 2021. We compared clinical factors between patients who died within 5 years after implantation (short-survival group: n = 31) and who had survived for more than 5 years (long-survival group: n = 36) after implantation. RESULTS: Major underlying heart diseases were dilated cardiomyopathy (45%) and ischemic heart disease (12%). There was no difference between the short-survival group and the long-survival group in incidence of CLBBB (32% vs. 30%), whereas CRBBB was more common in the short-survival group (26% vs. 0%, p = .004). Mechanical dyssynchrony at implantation was more frequent in the long-survival group (48% vs. 78%, p = .02). The incidence of response to CRT at 1 year after implantation was higher in long-survival group (19% vs. 50%, p = .02). Multiple logistic regression analysis identified NYHA class, mechanical dyssynchrony at implantation, and response at one year as predictors of long-term survival. CONCLUSIONS: In Japanese CRT-D cases, lower NHYA class, preexisting mechanical dyssynchrony, and 1-year response to CRT predict long-term survival.

    DOI： 10.1111/pace.14848

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  • Clinical impact of nocturnal ventricular tachyarrythmias in electrical storm. International journal

    Naomasa Suzuki, Sou Otsuki, Daisuke Izumi, Rie Akagawa, Yuta Sakaguchi, Takahiro Hakamata, Yasuhiro Ikami, Yuki Hasegawa, Nobue Yagihara, Kenichi Iijima, Masaomi Chinushi, Takayuki Inomata

    Pacing and clinical electrophysiology : PACE   45 ( 11 )   1330 - 1337   2022.11

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    BACKGROUND: The incidence of electrical storm (ES) is significantly higher during the daytime. However, the association between nocturnal ventricular tachyarrythmias during ES and prognosis remains unclear. Therefore, this study aimed to investigate the clinical characteristics and outcomes of ES with midnight ventricular tachyarrythmias. METHODS: We included 48 consecutive patients who had an implantable cardioverter-defibrillator or cardiac resynchronization therapy defibrillator implanted between 2010 and 2020 and those who had experienced the onset of an out-of-hospital ES episode. According to the midnight (0:00 a.m.-6:00 a.m.) occurrence of ventricular arrythmia events consisting of ventricular tachycardia (VT) and ventricular fibrillation (VF), we divided them into two groups (with-midnight group: n = 27, without-midnight group: n = 21). The clinical characteristics and outcomes of the two groups were compared. RESULTS: The patients in the with-midnight group were mostly males, had longer QRS duration, and longer corrected QT-interval than those in the without-midnight group (p &lt; .05). The incidence of all-cause death, especially heart failure death, was higher in the with-midnight group than in the without-midnight group (p &lt; .01). Multivariate analysis showed that the presence of midnight VT/VF during ES was the only independent risk factors for heart failure death (HR = 18.9, 95%CI = 1.98-181, p = .011). CONCLUSIONS: The presence of midnight VT/VF during ES might be associated with the poor prognosis. The loss of a sympathetic circadian pattern of VT/VF distribution during ES might suggest advanced stages of the cardiac disease.

    DOI： 10.1111/pace.14592

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  • Clinical impact of ECG changes on oversensing of subcutaneous implantable cardioverter-defibrillators. International journal

    Takahiro Hakamata, Sou Otsuki, Daisuke Izumi, Yuta Sakaguchi, Naomasa Suzuki, Yasuhiro Ikami, Yuki Hasegawa, Nobue Yagihara, Kenichi Iijima, Masaomi Chinushi, Koichi Fuse, Takayuki Inomata

    Heart rhythm   19 ( 10 )   1704 - 1711   2022.10

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    BACKGROUND: Inappropriate shocks delivered by subcutaneous implantable cardioverter-defibrillators (S-ICDs) are most frequently caused by cardiac oversensing. However, the predictors for oversensing of S-ICD remain unclear. OBJECTIVE: We aimed to investigate the predictors for oversensing of S-ICD, especially clinical impact of an electrocardiographic (ECG) change. METHODS: We retrospectively enrolled 99 consecutive patients who underwent S-ICD implantation between 2013 and 2021. Oversensing events were defined as inappropriate charge of the capacitors induced by cardiac or noncardiac signals other than tachycardia. RESULTS: During a median follow-up period of 34 months (interquartile range 20-50 months), 11 of 99 patients (11%) experienced 34 oversensing events and 4 patients (4%) received inappropriate shocks during their events. Six patients exhibited ECG changes (bundle branch block, 3; ventricular pacing, 1; inverted T wave, 1; poor R-wave progression, 1) during the follow-up period. Oversensing events were observed in 4 of 6 patients with ECG change (67%), and 3 patients underwent S-ICD removal because of inevitable shock. Contrastingly, of the remaining patients without ECG change, all 7 patients who experienced oversensing events could continue using S-ICD with the reprogramming sensing vector and/or restriction of excessive exercise. Logistic regression analysis showed that lower voltage of Sokolow-Lyon ECG (V1S + V5R) was the predictor of oversensing in patients without ECG change. When the cutoff value was 2.1 mV, the sensitivity, specificity, positive predictive value, and negative predictive value were 85.7%, 62.7%, 15.7%, and 98.1%, respectively. CONCLUSION: Unavoidable oversensing resulting in S-ICD removal is caused by ECG change. Oversensing in patients without ECG change can be managed.

    DOI： 10.1016/j.hrthm.2022.05.037

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  • Platypnea-orthodeoxia Syndrome Due to Right Ventricular Inflow Tract Obstruction Caused by an Elongated Ascending Aorta: Usefulness of Three-dimensional Cardiac Computed Tomography Imaging in the Sitting Position.

    Yuki Hasegawa, Daisuke Izumi, Yasuhiro Ikami, Takeshi Okubo, Makoto Hoyano, Kazuyuki Ozaki, Noriaki Sato, Takehito Mishima, Takayuki Inomata

    Internal medicine (Tokyo, Japan)   61 ( 15 )   2315 - 2317   2022.8

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    An 84-year-old woman presented with dyspnea in the sitting position. Platypnea-orthodeoxia syndrome (POS) was suspected based on arterial desaturation when her posture changed from the supine to the sitting position. Transesophageal echocardiography showed right-to-left shunting enhancement through a patent foramen ovale (PFO) in the sitting position. Three-dimensional (3D) cardiac CT in the sitting position revealed that the elongated ascending aorta compressed the right ventricular inflow tract, resulting in restricted blood flow to the right ventricle and increased right-to-left shunting. This case highlights the role of 3D-CT in the sitting position in the management of POS.

    DOI： 10.2169/internalmedicine.8868-21

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  • Angioscopic findings of organized thrombosis of iliac vein in patient with chronic thromboembolic pulmonary hypertension.

    Naoki Kubota, Kazuyuki Ozaki, Takahiro Hakamata, Yasuhiro Ikami, Makoto Hoyano, Tohru Minamino

    Cardiovascular intervention and therapeutics   37 ( 1 )   236 - 237   2022.1

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    DOI： 10.1007/s12928-020-00724-9

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  • The Risk of Ventricular Tachyarrhythmias in Patients with Antimitochondrial Antibodies-Related Noncardiac Diseases.

    Yasuhiro Ikami, Daisuke Izumi, Yuki Hasegawa, Naomasa Suzuki, Yuta Sakaguchi, Takahiro Hakamata, Sou Otsuki, Nobue Yagihara, Kenichi Iijima, Takeshi Kashimura, Masaomi Chinushi, Tohru Minamino, Takayuki Inomata

    International heart journal   63 ( 3 )   476 - 485   2022

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    Antimitochondrial antibodies (AMA) are serum autoantibodies specific to primary biliary cholangitis and are linked to myopathy and myocardial damage; however, the presence of AMA as a risk factor for ventricular tachyarrhythmias (VTs) has remained unknown. This study aimed to elucidate whether the presence of AMA-related noncardiac diseases indicates VTs risk.This cohort study enrolled 1,613 patients (883 females) who underwent AMA testing to assess noncardiac diseases. The incidence of VTs and supraventricular tachyarrhythmias (SVTs) from a year before the AMA testing to the last visit of the follow-up were retrospectively investigated as primary and secondary objectives. Using propensity score matching, we extracted AMA-negative patients whose covariates were matched to those of 152 AMA-positive patients. In this propensity score-matched cohort, the incidence of VTs and SVTs in the AMA-positive patients were compared with that in AMA-negative patients.The AMA-positive patients had higher estimated cumulative incidence (log-rank, P = 0.013) and prevalence (5.9% versus 0.7%, P = 0.020) of VTs than the AMA-negative patients. The presence of AMA was an independent risk factor for VTs (hazard ratio, 4.02; 95% CI, 1.44-20.01; P = 0.005). Meanwhile, AMA were associated with atrial flutter and atrial tachycardia development. In AMA-positive patients, VTs were associated with male sex, underlying myopathy, high creatine kinase levels, presence of chronic heart failure or ischemic heart disease, left ventricular dysfunction, presence of SVTs, and the electrocardiographic parameters indicating atrial disorders.The presence of AMA-related noncardiac diseases is an independent risk factor for VTs.

    DOI： 10.1536/ihj.22-075

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  • Efficacy of antitachycardia pacing alert by remote monitoring of implantable cardioverter-defibrillators for out-of-hospital electrical storm. International journal

    Sou Otsuki, Daisuke Izumi, Yuta Sakaguchi, Naomasa Suzuki, Takahiro Hakamata, Yasuhiro Ikami, Yuki Hasegawa, Nobue Yagihara, Kenichi Iijima, Masaomi Chinushi, Tohru Minamino, Inomata Takayuki

    Pacing and clinical electrophysiology : PACE   44 ( 10 )   1675 - 1682   2021.10

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    BACKGROUND: Remote monitoring (RM) has been shown to reduce all-cause mortality in patients with implantable cardioverter-defibrillators or cardiac resynchronization therapy defibrillators (ICD/CRT-D). Not all devices transmit an alert for antitachycardia pacing (ATP) therapy, and it is unknown whether differences of RM alert affect the outcomes of electrical storm (ES). METHODS: We enrolled 42 patients with ICD/CRT-D whose out-of-hospital ES were detected by RM between 2013 and 2020. We divided their 54 episodes into two groups (ATP-alert-on; 22, ATP-alert-off; 32), and clinical outcomes were compared between the two groups. RESULTS: In 35 of 54 episodes of ES, ventricular tachycardia (VT) could be terminated within 24 h of ES onset just by ATP (ATP-alert-on: 14, ATP-alert-off: 21); however, many patients subsequently received shock delivery for VT. Among the 35 episodes, only in ATP-alert-on group, seven patients were prompted to visit our hospital without ICD shock through confirmation of ES by ATP-alert. Episodes that led to shock delivery 24 h or longer after the ES onset were significantly less common in the ATP-alert-on group (ATP-alert-on: 1/14, ATP-alert-off: 9/21, p = .03). Although there were no significant differences in the number of shock deliveries between episodes in the two groups, the number of ATP deliveries were significantly fewer in the ATP-alert-on group (12[7-26] vs. 29[16-53] in ATP-alert-off group, p = .03). Multivariate logistic regression analyses showed that the only ATP-alert significantly reduced ATP deliveries (HR = 0.14, 95%CI = 0.04-0.57, p = .003). CONCLUSION: Remote monitoring with an ATP-alert function during electrical storm may reduce appropriate ICD therapy through prompting early review.

    DOI： 10.1111/pace.14334

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  • Response of the authors regarding article "J point elevation in high precordial leads associated with risk of ventricular fibrillation". International journal

    Yuki Hasegawa, Hiroshi Watanabe, Yasuhiro Ikami, Sou Otsuki, Kenichi Iijima, Nobue Yagihara, Daisuke Izumi, Tohru Minamino

    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc   26 ( 4 )   e12871   2021.7

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  • Progressive increase in activation delay during premature stimulation is related to ventricular fibrillation in Brugada syndrome. International journal

    Yuki Hasegawa, Daisuke Izumi, Yasuhiro Ikami, Sou Otsuki, Nobue Yagihara, Kenichi Iijima, Masaomi Chinushi, Tohru Minamino

    Journal of cardiovascular electrophysiology   32 ( 7 )   1939 - 1946   2021.7

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    INTRODUCTION: The local conduction delay has been deemed to play an important role in the perpetuation of ventricular fibrillation (VF) in Brugada syndrome (BrS). We evaluated the relationship between the activation delay during programmed stimulation and cardiac events in BrS patients. METHODS: This study included 47 consecutive BrS patients who underwent an electrophysiological study and received implantable cardiac defibrillator therapy. We divided the patients into two groups based on whether they had developed VF (11 patients) or not (36 patients) during the follow-up period of 89 ± 53 months. The activation delay was assessed using the interval between the stimulus and the QRS onset during programmed stimulation. The mean increase in delay (MID) was used to characterize the conduction curves. RESULTS: The MID at the right ventricular outflow tract (RVOT) was significantly greater in patients with VF (4.5 ± 1.2 ms) than in those without VF (2.2 ± 0.9 ms) (p < .001). A receiver operating characteristics curve analysis indicated that the optimal cut-off point for discriminating VF occurrence was 3.3 with 88.9% sensitivity and 91.3% specificity. Furthermore, patients with an MID at the RVOT ≥ 3.3 ms showed significantly higher rates of VF recurrence than those with an MID at the RVOT < 3.3 ms (p < .001). The clinical characteristics, including the signal-averaged electrocardiogram measurement and VF inducibility were similar between the two groups. CONCLUSION: A prolonged MID at the RVOT was associated with VF and maybe an additional electrophysiological risk factor for VF in BrS patients.

    DOI： 10.1111/jce.15065

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  • J point elevation in high precordial leads associated with risk of ventricular fibrillation. International journal

    Yuki Hasegawa, Hiroshi Watanabe, Yasuhiro Ikami, Sou Otsuki, Kenichi Iijima, Nobue Yagihara, Daisuke Izumi, Tohru Minamino

    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc   26 ( 3 )   e12820   2021.5

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    INTRODUCTION: The significance of high precordial electrocardiograms in idiopathic ventricular fibrillation (IVF) is unknown. METHOD: This study included 50 consecutive patients (48 men; age, 42 ± 18 years) who had spontaneous ventricular fibrillation not linked to structural heart disease and received implantable cardiac defibrillator therapy. IVF was diagnosed in 35 patients and Brugada syndrome was diagnosed in other 15 patients. Electrocardiograms in high intercostal space were compared between 35 patients with IVF and 105 age- and sex-matched healthy controls (patient: control ratio, 1:3). RESULTS: The frequency of J point elevation ≥ 0.1 mV in the 4th intercostal spaces was similar between patients with IVF (14%) and healthy controls (7%). However, the frequency of J point elevation ≥ 0.1 mV in the 3rd intercostal space was higher in patients with IVF (40%) than controls (11%) (p < .01). J point elevation was present only in the 3rd intercostal space but not in the 4th intercostal space in 30% of patients with IVF but only in 6% of controls (p < .01). During follow-up, the recurrence of ventricular fibrillation was higher in patients with IVF who had J point elevation in the 3rd intercostal space (36%) and Brugada syndrome(40%) than those with IVF who did not have J point elevation in the 3rd intercostal space(11%) (p < .05 for both). CONCLUSION: J point elevation in the 3rd intercostal space was associated with IVF and recurrences of ventricular fibrillation. Electrocardiogram recordings in the high intercostal space may be useful to identify risk of sudden death.

    DOI： 10.1111/anec.12820

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  • Early repolarization and risk of lone atrial fibrillation. International journal

    Yuki Hasegawa, Hiroshi Watanabe, Yasuhiro Ikami, Sou Otsuki, Kenichi Iijima, Nobue Yagihara, Akinori Sato, Daisuke Izumi, Tohru Minamino

    Journal of cardiovascular electrophysiology   30 ( 4 )   565 - 568   2019.4

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    INTRODUCTION: Early repolarization syndrome is a recently proposed condition characterized by an early repolarization pattern in the electrocardiogram (ECG) and ventricular fibrillation in the absence of structural heart abnormalities. Although some studies have suggested that early repolarization is associated with frequency of atrial fibrillation, the association of early repolarization with atrial fibrillation is not well known. HYPOTHESIS: Early repolarization indicates the substrate for atrial fibrillation in addition to that for ventricular fibrillation. METHOD: This study included 79 patients (57 men [72%]; age, 45 ± 12 years) aged less than 60 years who had paroxysmal lone atrial fibrillation and 395 age- and sex-matched healthy controls (patient:control ratio, 1:5). Patients who had structural heart disease, hypertension, diabetes, hyperthyroidism, history of successful resuscitation, or the Brugada type ECG were excluded. ECGs recorded during sinus rhythm were compared between patients with atrial fibrillation and healthy controls. RESULTS: Early repolarization in the inferior and/or lateral leads was more common in patients with atrial fibrillation (25%) than controls (10%; P = 0.001). The location and magnitude of early repolarization were similar between the two groups. Other electrocardiographic measurements were not different between the two groups. Among patients with atrial fibrillation, there was no difference in clinical characteristics including age at atrial fibrillation development, sex, and body mass index between patients with early repolarization and those without early repolarization. Electrocardiographic measurements were not different between patients with early repolarization and those without early repolarization. CONCLUSION: Early repolarization was associated with lone atrial fibrillation. Early repolarization may indicate increased susceptibility to atrial fibrillation.

    DOI： 10.1111/jce.13848

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  • Bidirectional Shunt Trajectory in Ventricular Septal Defect With Eisenmenger's Syndrome.

    Hiromi Kayamori, Takeshi Kashimura, Yosuke Horii, Tsutomu Kanazawa, Toshio Fujita, Naoki Kubota, Yasuhiro Ikami, Toshiki Takano, Takeshi Okubo, Makoto Hoyano, Takao Yanagawa, Takuya Ozawa, Kazuyuki Ozaki, Tohru Minamino

    Circulation journal : official journal of the Japanese Circulation Society   82 ( 11 )   2925 - 2926   2018.10

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    DOI： 10.1253/circj.CJ-18-0332

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Awards

  • カテーテルアブレーション関連秋季大2021 Best Abstract賞優秀賞

    2021.9   日本不整脈心電学会   心房細動アブレーションに対する多点pacingによる3D mapping法(Escape mapping)の有用性の検討

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  • 第249回関東甲信越地方会 Case Report Award優秀賞

    2018.9   日本循環器学会   経静脈的に冠静脈洞の腫瘍生検を行った悪性リンパ腫の1例

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