Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Royal College of Psychiatrists  

DOI： 10.1192/j.eurpsy.2022.12

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Authorship：Lead author   Language：Japanese   Publisher：Japanese Association for Behavioral and Cognitive Therapies( JABCT )  

Limited evidence has shown how the therapeutic effects of psychotherapies have been obtained compared to abundant evidence based on the changes in the clinical outcome scores. Psychotherapy depends on interactive therapeutic conversations. Hence, topic models have recently attracted attention for linguistic information as data-driven computational approaches can produce objective and reproducible models. This study examined whether a dynamic topic model with a time-series structure could extract treatment session content from single-case conversation data during a structured behavioral activation program. We extracted four potential topics during the treatment sessions. The quantitative transition process reflected the program treatment contents. This is the first study to apply the dynamic topic model for conversation during psychotherapy, which quantifies the actual treatment process. The results show cumulative evidence of the effects of psychotherapy.

DOI： 10.24468/jjbct.20-034

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jad.2017.10.021

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00787-016-0842-5

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Other Link： http://link.springer.com/article/10.1007/s00787-016-0842-5/fulltext.html

Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jpain.2026.106300

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DOI： 10.1016/j.jbct.2026.100599

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Major depressive disorder (MDD), characterized primarily by mood disturbances, is also accompanied by abnormal cardiovascular functioning. However, the neuroanatomical substrates underlying this cardiovascular dysfunction remain elusive. METHODS: In this study, we investigated the neuroanatomical foundations of cardiac dysfunction in MDD. Using magnetic resonance imaging, we examined differences in gray matter volume (GMV) between patients with MDD (n = 81) and healthy control (HC) participants (n = 104) in regions implicated in cardiovascular regulation, notably the insula, anterior cingulate cortex (ACC), thalamus, and brainstem nuclei. Photoplethysmography signals acquired during a 10-minute resting state provided data to investigate group differences in heart rate variability (HRV) metrics (e.g., heart rate, low- and high-frequency components). Correlations and mixed-effect linear regression models tested the strength of group differences in the association between HRV metrics and regional GMV. Mediation analyses evaluated whether GMV mediated the observed group differences in HRV. RESULTS: Patients with MDD had faster heart rates and reduced HRV compared with HC participants. Neuroanatomically, patients with MDD manifested significantly reduced GMV across the insula, ACC, hippocampus, thalamus, and cerebellum. Negative correlations between insula GMV and HRV metrics were found in HC participants but not in patients with MDD. Regression models confirmed a stronger association between insula volume and HRV metrics in HC participants. Mediation analyses revealed that differences in cardiac measures explain the reduced insula GMV differences between diagnostic groups. CONCLUSIONS: These findings reveal a disrupted heart-brain relationship in MDD, notably a link between cardiac dysregulation and reduced insula volume. This highlights the importance of potential body-brain targets for therapeutic intervention in mood disorders.

DOI： 10.1016/j.biopsych.2026.03.997

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Language：English   Publishing type：Research paper (scientific journal)  

PURPOSE: Subthreshold depression (StD), depressive symptoms below the diagnostic threshold for major depressive disorder (MDD), is associated with functional impairment and increased risk of MDD onset, but its physiological and cognitive characteristics remain unclear. This study aimed to identify objective markers of StD and validate predictive factors for MDD onset. PATIENTS AND METHODS: Among 168 university students, participants were classified into a StD group (n=87) and a healthy control group (n=81) using the Beck Depression Inventory-II (BDI-II). The StD group was further subdivided into "low depression" (BDI-II < 10, n = 21) and "maintained depression" (BDI-II ≥ 10, n = 66) based on their BDI-II scores at baseline. Assessments included voice characteristics, heart rate variability (HRV), peripheral body temperature, emotion recognition, and neurocognitive tasks. Between-group differences were tested using ANOVA and MANOVA, and participants were followed for MDD onset at 3-month intervals until March 2024. RESULTS: Compared to controls, the StD group showed increased vocal arousal (p = 0.007), elevated peripheral body temperature (p < 0.001), and reduced low-frequency HRV (p = 0.018). Sustained attention and executive function were impaired (p < 0.05). Accuracy in emotion recognition was lower for happy and surprised expressions (p = 0.030; p = 0.038). Subgroup analysis revealed more pronounced impairments in HRV, executive function, and emotion recognition in the maintained depression subgroup, which also had a higher MDD incidence (7 cases). In contrast, the low depression group showed selective attentional deficits and impaired emotion recognition, but no MDD onset. CONCLUSION: StD correlates with physiological and cognitive abnormalities reflecting MDD, and persistent symptoms suggest increased progression risk. These findings present candidate markers (voice arousal, HRV, body temperature, emotion recognition) for early identification and risk stratification; however, conclusions should be interpreted cautiously given the exploratory design.

DOI： 10.2147/NDT.S526034

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Chronic pain imposes a substantial burden on individuals and society. Cognitive behavioral therapy for chronic pain (CBT-CP) has proven effective internationally, but randomized evidence in Japan is scarce. The first Japanese trial was a single-center, 16-session videoconference program that prioritized pain intensity. In contrast, this multicenter trial tests a brief, face-to-face, individualized CBT-CP program with quality of life (QoL) as the primary outcome. METHODS: This open-label, randomized, parallel-group superiority trial enrolls 60 adults aged 20-80 years with chronic pain persisting ≥ 3 months and EQ-5D-5L scores ≤ 0.80, indicating reduced QoL. Participants are randomized 1:1 to treatment as usual (TAU) plus an eight-session CBT-CP program or to a waitlist control receiving TAU only. The manualized intervention includes psycho-education, relaxation, activity pacing, and cognitive restructuring, delivered weekly face-to-face, with the goal of completing eight sessions within 14 weeks. If necessary, sessions may extend beyond the 15th week; however, the post-assessment is always conducted at 15 ± 2 weeks irrespective of intervention timing. Therapists meet prespecified eligibility criteria and receive structured training, supervision, and fidelity monitoring. The primary outcome is QoL (EQ-5D-5L) at 15 ± 2 weeks. Secondary outcomes include pain intensity, disability, depressive symptoms, catastrophizing, fear of movement, pain self-efficacy, and health-related QoL assessed by the SF-12. These outcomes, together with prognostic risk and somatic symptom burden, will also be examined as potential mediators or moderators. The intervention group undergoes a 27 ± 2-week follow-up to explore mid-term durability in a single-arm pre/post analysis. Analyses follow the intent-to-treat principle using linear mixed models, with effect sizes and confidence intervals reported; multiplicity will be considered in interpreting secondary outcomes. Blinding of participants and therapists is not feasible. DISCUSSION: This trial will clarify the added value of a brief, fidelity-assured, face-to-face CBT-CP program in Japan, where implementation remains limited. Findings are expected to guide clinical adoption, workforce training, and dissemination, while also generating hypotheses about for whom and through which processes CBT-CP may confer benefit. TRIAL REGISTRATION: University Hospital Medical Information Network Clinical Trials Registry, UMIN000042798. Registered on 21 December 2020, https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048858 .

DOI： 10.1186/s13063-025-09153-6

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s11548-025-03500-3

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.neunet.2025.107335

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.7759/cureus.75351

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Language：English   Publishing type：Research paper (scientific journal)  

Subthreshold depression is a risk factor for depression among university students. Positive environmental reinforcement is a significant mediator of avoidance and depression in healthy university students. However, this relationship is understudied in those with subthreshold depression or depression. Therefore, this study examined these associations in healthy university students and those who fit the criteria for subthreshold depression or depression. We conducted an online survey with 1200 undergraduate students (600 women and 600 men, mean age = 20.61, SD = 1.59). The results revealed significant differences in avoidance patterns (behavioral social, behavioral nonsocial, cognitive social, and cognitive nonsocial), with participants with depression presenting the highest scores. The results of the mediation analysis were similar to those of previous studies in healthy groups. However, in the subthreshold-depression group, positive environmental reinforcement was mediated by behavioral social and behavioral non-social avoidance and depressive symptoms. In the group with depression, positive environmental reinforcement was mediated only by behavioral nonsocial avoidance and depressive symptoms. Associations between avoidance patterns, positive environmental reinforcement, and depressive symptoms vary with the degree of depressive symptoms. The results revealed by this study provide new foundational insights to prevent subthreshold depression among university students from deteriorating into depression.

DOI： 10.3390/bs14080713

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BACKGROUND AND AIMS: Research suggests that various psychosocial factors influence chronic pain, with psychotherapies like cognitive behavioral therapy  proving effective. However, the limited availability and accessibility have prolonged suffering among patients with chronic pain. This challenge has led to a growing demand for accessible online interventions. We developed an online cognitive behavioral group therapy (CBGT) program, building upon our existing face-to-face CBGT program. We compared the scores obtained by patients during the treatment-as-usual (TAU) period with those collected at the beginning and at the end of the intervention. METHODS: Patients with chronic pain (N = 22) agreed to participate in the online CBGT program, which was conducted once a week for 12 sessions. The sample size was decided based on the effect sizes of our past face-to-face CBGT. We assessed pain intensity [Visual Analogue Scale (VAS)], pain catastrophizing [pain catastrophizing scale (PCS)] and psychiatric assessment [Beck Depression Inventory-Second Edition (BDI)-II], State-Trait-Anxiety Inventory (STAI), and Short Form Health Survey (SF-36) at three points: entry, pretreatment, and posttreatment. We also evaluated the participants' therapeutic alliance with the treatment staff [short-form version of the Working Alliance Inventory (WAI-S)]. We utilized analyses of variance, Friedman test, paired t-tests, Wilcoxon signed-rank test, and Pearson correlation analysis for data evaluation. RESULTS: Results indicated a significant posttreatment improvement in VAS, PCS, and BDI-II scores compared to the TAU period. Furthermore, posttreatment WAI-S scores increased significantly compared to pretreatment scores. Also, positive correlations were observed among pre- and posttreatment changes in WAI-S, pain intensity, and pain catastrophizing scores. CONCLUSION: There is a possibility that a therapeutic alliance can be established, and therapeutic effects achieved through an online CBGT intervention; however, additional research is required to substantiate this potential. We have registered this clinical trial in UMIN-CTR on 04/21/2021 with the number UMIN000043982.

DOI： 10.1002/hsr2.2141

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Language：English   Publishing type：Research paper (scientific journal)  

INTRODUCTION: Depression is highly prevalent among university students. While behavioral activation has been shown to be an effective psychotherapy for depression, there is a lack of research regarding the behavioral activation mechanism. Furthermore, although self-compassion seems to be a factor in promoting behavioral activation, no studies have attempted to validate a behavioral activation model that includes positive self-compassion. In addition, mechanistic studies have lacked consideration in longitudinal studies of behavioral activation. Thus, in this longitudinal study, we constructed and validated an exploratory model of behavioral activation. METHODS: A total of 300 undergraduate students completed online surveys in 2019, 2020, and 2021. We examined the longitudinal effects of five factors (value-based behavior, goal-oriented and scheduled activities, positive reinforcement, self-compassion, and depressive symptoms) using structural equation modeling based on maximum likelihood estimation using bootstrapping. RESULTS: The exploratory model was found to be valid and to have a good fit with the data. The results indicate that value-based behaviors increase the frequency of goal-oriented and scheduled activities, which in turn increases the frequency of positive reinforcement in everyday life. Additionally, when self-compassion, value-based behavior, goal-oriented and scheduled activities, and positive reinforcement are considered together, self-compassion may be indirectly related to activation via value-based behavior. CONCLUSION: From the perspective of preventing depressive symptoms, it is important to increase the frequency of value-based activities. Furthermore, adding self-compassion is effective in behavioral activation to increase value-based activities. However, to address the limitations of this study, future studies should investigate the relationship among behavioral characteristics during interventions.

DOI： 10.1159/000538266

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The integrated model of rumination argues that two trait factors-negative thinking habits and processing modes-get people stuck in maladaptive rumination. There is little evidence showing whether these factors influence the daily dynamic associations between rumination and negative moods. To address this, in this study, we conducted an experience-sampling method on Japanese university students. We recruited 92 Japanese university students and assessed their daily rumination and negative affect (NA) eight times a day for seven days. We examined the effects of habits and processing modes on the dynamic associations between rumination and negative moods using dynamic structural equation modeling. We found that individuals were more likely to ruminate when they experienced NA. However, contrary to previous findings, this study's participants did not experience NA after engaging in rumination. Moreover, we did not detect any significant trait factor effect on these dynamic associations. Our findings imply that individuals are more likely to engage in rumination after experiencing NA, but the reverse association, particularly the autoregression of rumination, may not be maintained in natural daily life. Furthermore, negative thinking habits and processing modes may not influence the daily dynamic associations between rumination and NA among Japanese university students.

DOI： 10.1038/s41598-024-55174-7

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<jats:p>The objective diagnostic and stratification biomarkers developed with resting-state functional magnetic resonance imaging (rs-fMRI) data are expected to contribute to more effective treatment for mental disorders. Unfortunately, there are currently no widely accepted biomarkers, partially due to the large variety of analysis pipelines for developing them. In this study we comprehensively evaluated analysis pipelines using a large-scale, multi-site fMRI dataset for major depressive disorder (MDD) (1162 participants from eight imaging sites). We explored the combinations of options in four subprocesses of analysis pipelines: six types of brain parcellation, four types of estimations of functional connectivity (FC), three types of site difference harmonization, and five types of machine learning methods. 360 different MDD diagnostic biomarkers were constructed using the SRPBS dataset acquired with unified protocols (713 participants from four imaging sites) as a discovery dataset and evaluated with datasets from other projects acquired with heterogeneous protocols (449 participants from four imaging sites) for independent validation. To identify the optimal options regardless of the discovery dataset, we repeated the same procedure after swapping the roles of the two datasets. We found pipelines that included Glasser's parcellation, tangent-covariance, no harmonization, and non-sparse machine learning methods tended to result in high classification performance. The diagnosis results of the top 10 biomarkers showed high similarity, and weight similarity was also observed between eight of the biomarkers, except two that used both data-driven parcellation and FC computation. We applied the top 10 pipelines to the datasets of other mental disorders (autism spectral disorder: ASD and schizophrenia: SCZ) and eight of the ten biomarkers showed sufficient classification performances for both disorders, except two pipelines that included Pearson correlation, ComBat harmonization and random forest classifier combination.</jats:p>

DOI： 10.1101/2024.03.17.584538

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Society of Behavioral Medicine  

DOI： 10.11331/jjbm.29.60

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Language：English   Publishing type：Research paper (scientific journal)  

According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder (ASD) are classified based on symptoms. While its cluster of symptoms defines each of these psychiatric disorders, there is also an overlap in symptoms between the disorders. We hypothesized that there are also similarities and differences in cortical structural neuroimaging features among these psychiatric disorders. T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects recruited from 14 sites. Effect sizes were determined using a linear regression model within each protocol, and these effect sizes were meta-analyzed. The similarity of the differences in cortical thickness and surface area of each disorder group was calculated using cosine similarity, which was calculated from the effect sizes of each cortical regions. The thinnest cortex was found in SZ, followed by BD and MDD. The cosine similarity values between disorders were 0.943 for SZ and BD, 0.959 for SZ and MDD, and 0.943 for BD and MDD, which indicated that a common pattern of cortical thickness alterations was found among SZ, BD, and MDD. Additionally, a generally smaller cortical surface area was found in SZ and MDD than in BD, and the effect was larger in SZ. The cosine similarity values between disorders were 0.945 for SZ and MDD, 0.867 for SZ and ASD, and 0.811 for MDD and ASD, which indicated a common pattern of cortical surface area alterations among SZ, MDD, and ASD. Patterns of alterations in cortical thickness and surface area were revealed in the four major psychiatric disorders. To our knowledge, this is the first report of a cross-disorder analysis conducted on four major psychiatric disorders. Cross-disorder brain imaging research can help to advance our understanding of the pathogenesis of psychiatric disorders and common symptoms.

DOI： 10.1038/s41380-023-02224-7

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Language：English   Publishing type：Research paper (scientific journal)  

Differential diagnosis is sometimes difficult in practical psychiatric settings, in terms of using the current diagnostic system based on presenting symptoms and signs. The creation of a novel diagnostic system using objective biomarkers is expected to take place. Neuroimaging studies and others reported that subcortical brain structures are the hubs for various psycho-behavioral functions, while there are so far no neuroimaging data-driven clinical criteria overcoming limitations of the current diagnostic system, which would reflect cognitive/social functioning. Prior to the main analysis, we conducted a large-scale multisite study of subcortical volumetric and lateralization alterations in schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum disorder using T1-weighted images of 5604 subjects (3078 controls and 2526 patients). We demonstrated larger lateral ventricles volume in schizophrenia, bipolar disorder, and major depressive disorder, smaller hippocampus volume in schizophrenia and bipolar disorder, and schizophrenia-specific smaller amygdala, thalamus, and accumbens volumes and larger caudate, putamen, and pallidum volumes. In addition, we observed a leftward alteration of lateralization for pallidum volume specifically in schizophrenia. Moreover, as our main objective, we clustered the 5,604 subjects based on subcortical volumes, and explored whether data-driven clustering results can explain cognitive/social functioning in the subcohorts. We showed a four-biotype classification, namely extremely (Brain Biotype [BB] 1) and moderately smaller limbic regions (BB2), larger basal ganglia (BB3), and normal volumes (BB4), being associated with cognitive/social functioning. Specifically, BB1 and BB2-3 were associated with severe and mild cognitive/social impairment, respectively, while BB4 was characterized by normal cognitive/social functioning. Our results may lead to the future creation of novel biological data-driven psychiatric diagnostic criteria, which may be expected to be useful for prediction or therapeutic selection.

DOI： 10.1038/s41380-023-02141-9

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Language：Japanese   Publisher：(国研)国立精神・神経医療研究センター精神保健研究所  

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University students are in a phase during which they have various experiences typical in the academic environment and face situations that require adaptability and influence value formation. In the abnormal situation of the COVID-19 pandemic, university students' life rhythms, academic, interpersonal, and financial situations have changed drastically. In those situational cues, the value-based behavior of university students may have changed. Values provide purpose and direction for each action. Furthermore, values are situational goals that lead to specific real-time behavior. Therefore, this study aimed to examine whether there is a two-way influencing relationship between value-based behavior and scheduled activities of university students at two points in time (before the COVID-19 pandemic and during the COVID-19 pandemic). 417 university students answered a questionnaire at Times 1 and 2 (with a 1-year interval). We examined the relationship between value-based behavior and scheduled activities using a longitudinal cross-lagged model analysis. The findings of this study indicate that promoting value-based behaviors is positively associated with the frequency of value-based behaviors and scheduled activities even during anomalies such as the COVID-19 pandemic. Even in anomalous situations such as the COVID-19 pandemic, increasing value-based behaviors such as behavioral activation can improve the lives of university students. Future intervention studies should show whether behavioral activation is effective in decreasing depressive symptoms among university students even in abnormal situations such as the COVID-19 pandemic.

DOI： 10.1159/000530909

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Abstract

Although the identification of late adolescents with subthreshold depression (StD) may provide a basis for developing effective interventions that could lead to a reduction in the prevalence of StD and prevent the development of major depressive disorder, knowledge about the neural basis of StD remains limited. The purpose of this study was to develop a generalizable classifier for StD and to shed light on the underlying neural mechanisms of StD in late adolescents. Resting-state functional magnetic resonance imaging data of 91 individuals (30 StD subjects, 61 healthy controls) were included to build an StD classifier, and eight functional connections were selected by using the combination of two machine learning algorithms. We applied this biomarker to an independent cohort (n = 43) and confirmed that it showed generalization performance (area under the curve = 0.84/0.75 for the training/test datasets). Moreover, the most important functional connection was between the left and right pallidum, which may be related to clinically important dysfunctions in subjects with StD such as anhedonia and hyposensitivity to rewards. Investigation of whether modulation of the identified functional connections can be an effective treatment for StD may be an important topic of future research.

DOI： 10.1038/s41598-023-33077-3

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Other Link： https://www.nature.com/articles/s41598-023-33077-3

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.jbtep.2023.101857

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(一社)日本総合病院精神医学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1111/pcn.13542

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND AND HYPOTHESIS: Dynamics of the distributed sets of functionally synchronized brain regions, known as large-scale networks, are essential for the emotional state and cognitive processes. However, few studies were performed to elucidate the aberrant dynamics across the large-scale networks across multiple psychiatric disorders. In this paper, we aimed to investigate dynamic aspects of the aberrancy of the causal connections among the large-scale networks of the multiple psychiatric disorders. STUDY DESIGN: We applied dynamic causal modeling (DCM) to the large-sample multi-site dataset with 739 participants from 4 imaging sites including 4 different groups, healthy controls, schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD), to compare the causal relationships among the large-scale networks, including visual network, somatomotor network (SMN), dorsal attention network (DAN), salience network (SAN), limbic network (LIN), frontoparietal network, and default mode network. STUDY RESULTS: DCM showed that the decreased self-inhibitory connection of LIN was the common aberrant connection pattern across psychiatry disorders. Furthermore, increased causal connections from LIN to multiple networks, aberrant self-inhibitory connections of DAN and SMN, and increased self-inhibitory connection of SAN were disorder-specific patterns for SCZ, MDD, and BD, respectively. CONCLUSIONS: DCM revealed that LIN was the core abnormal network common to psychiatric disorders. Furthermore, DCM showed disorder-specific abnormal patterns of causal connections across the 7 networks. Our findings suggested that aberrant dynamics among the large-scale networks could be a key biomarker for these transdiagnostic psychiatric disorders.

DOI： 10.1093/schbul/sbad022

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BACKGROUND: Recently, we developed a generalizable brain network marker for the diagnosis of major depressive disorder (MDD) across multiple imaging sites using resting-state functional magnetic resonance imaging. Here, we applied this brain network marker to newly acquired data to verify its test-retest reliability and anterograde generalization performance for new patients. METHODS: We tested the sensitivity and specificity of our brain network marker of MDD using data acquired from 43 new patients with MDD as well as new data from 33 healthy controls (HCs) who participated in our previous study. To examine the test-retest reliability of our brain network marker, we evaluated the intraclass correlation coefficients (ICCs) between the brain network marker-based classifier's output (probability of MDD) in two sets of HC data obtained at an interval of approximately 1 year. RESULTS: Test-retest correlation between the two sets of the classifier's output (probability of MDD) from HCs exhibited moderate reliability with an ICC of 0.45 (95 % confidence interval,0.13-0.68). The classifier distinguished patients with MDD and HCs with an accuracy of 69.7 % (sensitivity, 72.1 %; specificity, 66.7 %). LIMITATIONS: The data of patients with MDD in this study were cross-sectional, and the clinical significance of the marker, such as whether it is a state or trait marker of MDD and its association with treatment responsiveness, remains unclear. CONCLUSIONS: The results of this study reaffirmed the test-retest reliability and generalization performance of our brain network marker for the diagnosis of MDD.

DOI： 10.1016/j.jad.2023.01.087

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COVID-19 has exposed university students to high-stress situations, and the percentage of individuals with depressive symptoms was high during the COVID-19 pandemic. Furthermore, subthreshold depression carries a risk for the subsequent development of major depressive disorder (MDD). During the COVID-19 pandemic, we examined whether differences exist between university students who deteriorated from subthreshold depression to MDD and those who remained stable or improved. Four hundred seventeen participants completed all the measures twice over a one-year interval. One hundred twenty-three participants met the criteria for subthreshold depression at Time 1. One year later, 42 participants no longer met the criteria for subthreshold depression, 68 participants maintained the criteria for subthreshold depression, and 13 participants met the criteria for MDD. We conducted two-way repeated measures ANOVA to examine the differences between those who deteriorated from subthreshold depression to MDD and those who did not. The study results suggest that avoidance behavior is associated with the development of MDD from subthreshold depression. Additionally, the study showed that experiencing isolation relates to MDD onset. Therefore, we should monitor avoidance behavior and isolation in pandemic conditions. Consequently, attention to avoidance behavior and isolation may be important; however, further research is required.

DOI： 10.3390/bs13010072

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Language：Japanese   Publisher：(一社)日本総合病院精神医学会  

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Trust attitude is a social personality trait linked with the estimation of others' trustworthiness. Trusting others, however, can have substantial negative effects on mental health, such as the development of depression. Despite significant progress in understanding the neurobiology of trust, whether the neuroanatomy of trust is linked with depression vulnerability remains unknown. To investigate a link between the neuroanatomy of trust and depression vulnerability, we assessed trust and depressive symptoms and employed neuroimaging to acquire brain structure data of healthy participants. A high depressive symptom score was used as an indicator of depression vulnerability. The neuroanatomical results observed with the healthy sample were validated in a sample of clinically diagnosed depressive patients. We found significantly higher depressive symptoms among low trusters than among high trusters. Neuroanatomically, low trusters and depressive patients showed similar volume reduction in brain regions implicated in social cognition, including the dorsolateral prefrontal cortex (DLPFC), dorsomedial PFC, posterior cingulate, precuneus, and angular gyrus. Furthermore, the reduced volume of the DLPFC and precuneus mediated the relationship between trust and depressive symptoms. These findings contribute to understanding social- and neural-markers of depression vulnerability and may inform the development of social interventions to prevent pathological depression.

DOI： 10.1038/s41598-022-20443-w

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

AIM: To establish treatment response biomarkers that reflect the pathophysiology of depression, it is important to use an integrated set of features. This study aimed to determine the relationship between regional brain activity at rest and blood metabolites related to treatment response to escitalopram to identify the characteristics of depression that respond to treatment. METHODS: Blood metabolite levels and resting-state brain activity were measured in patients with moderate to severe depression (n = 65) before and after 6-8 weeks of treatment with escitalopram, and these were compared between Responders and Nonresponders to treatment. We then examined the relationship between blood metabolites and brain activity related to treatment responsiveness in patients and healthy controls (n = 36). RESULTS: Thirty-two patients (49.2%) showed a clinical response (>50% reduction in the Hamilton Rating Scale for Depression score) and were classified as Responders, and the remaining 33 patients were classified as Nonresponders. The pretreatment fractional amplitude of low-frequency fluctuation (fALFF) value of the left dorsolateral prefrontal cortex (DLPFC) and plasma kynurenine levels were lower in Responders, and the rate of increase of both after treatment was correlated with an improvement in symptoms. Moreover, the fALFF value of the left DLPFC was significantly correlated with plasma kynurenine levels in pretreatment patients with depression and healthy controls. CONCLUSION: Decreased resting-state regional activity of the left DLPFC and decreased plasma kynurenine levels may predict treatment response to escitalopram, suggesting that it may be involved in the pathophysiology of major depressive disorder in response to escitalopram treatment.

DOI： 10.1111/pcn.13373

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13373

Language：Japanese   Publisher：(国研)国立精神・神経医療研究センター精神保健研究所  

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DOI： 10.1038/s41598-022-06563-3

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Other Link： https://www.nature.com/articles/s41598-022-06563-3

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

Attention function is thought to be important in chronic pain, with the pathology of chronic pain closely associated with cognitive-emotional components. However, there have been few neuroimaging studies of the relationship between attention function and chronic pain. We used the method of functional connectivity analysis for resting-state fMRI (rs-fMRI) data and the Attention Network Test-Revision (ANT-R) to clarify the attention-related pathology of chronic pain. We performed rs-fMRI and ANT-R on a group of 26 chronic pain (somatoform pain disorder) patients and 28 age-matched healthy controls. A significant group difference in validity effects, a component of ANT-R, emerged (F1,46 = 5.91, p = 0.019), and the chronic pain group exhibited slower reaction times. Decreased brain connectivity of the left insula and left frontal regions was confirmed in chronic pain patients (pFWE < 0.05), and connectivity was negatively correlated with validity effects (r = -0.29, permutation test p = 0.033). Further, decreased functional connectivity strength of the right insula and left temporal gyrus in the chronic pain group were confirmed (pFWE < 0.05). We conclude that poor control of attention function results from deficits of functional connectivity in the left insula and left frontal regions in chronic pain.

DOI： 10.1016/j.bandc.2021.105806

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Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

DOI： 10.3389/fpsyg.2021.566181

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DOI： 10.21203/rs.3.rs-911537/v1

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s41811-021-00108-8

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Other Link： https://link.springer.com/article/10.1007/s41811-021-00108-8/fulltext.html

Publishing type：Research paper (scientific journal)   Publisher：科学評論社  

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Publishing type：Research paper (scientific journal)  

DOI： 10.1111/pcn.13166

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13166

Publishing type：Research paper (scientific journal)  

DOI： 10.1002/brb3.1868

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/brb3.1868

Language：Japanese  

DOI： 10.15027/50080

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Other Link： http://id.ndl.go.jp/bib/030660084

Publishing type：Research paper (scientific journal)  

DOI： 10.3389/fnhum.2020.00165

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Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media {SA}  

DOI： 10.3389/fpsyg.2019.02536

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Publishing type：Research paper (scientific journal)  

DOI： 10.3389/fnhum.2019.00289

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DOI： 10.2147/NDT.S172385

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Publishing type：Research paper (scientific journal)  

DOI： 10.1192/bjo.2018.40

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DOI： 10.2147/NDT.S168077

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Publishing type：Research paper (scientific journal)   Publisher：Cambridge University Press (CUP)  

DOI： 10.1017/S0033291717002598

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1097/wnr.0000000000000818

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DOI： 10.1038/s41598-017-03522-1

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Other Link： http://www.nature.com/articles/s41598-017-03522-1

Publishing type：Research paper (scientific journal)  

DOI： 10.1017/S0033291716002956

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Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jad.2016.06.046

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Language：Japanese   Publisher：(一社)日本認知・行動療法学会  

DOI： 10.24468/jjbt.42.2_237

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J00454&link_issn=&doc_id=20160822010016&doc_link_id=%2Fdr4behav%2F2016%2F004202%2F017%2F0237-0246%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdr4behav%2F2016%2F004202%2F017%2F0237-0246%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Anxiety Disorders  

This study explored the relationship between the neutral and negative interpretation, and explored the influence of the positive, neutral, and negative interpretations in ambiguous events for SAD patients. In this study, 50 SAD patients completed (1) the Japanese version of the Liebowitz Social Anxiety Scale (Asakura et al., 2002); (2) the interpretation measure of ambiguous events. The results of correlation analysis revealed that the negative interpretation did not relate to neutral interpretation but positive interpretation (<i>r</i>=-.48, <i>p</i><.001) in social events. The regression analysis revealed that the influence of negative interpretation in social events predicted social anxiety symptoms (β=.34, <i>p</i><.05). The results suggest that to benign negative interpretations of ambiguous events will be decrease social anxiety symptoms by increasing positive interpretation of them.

DOI： 10.14389/jsad.6.2_63

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Anxiety Disorders  

DOI： 10.14389/adr.6.7

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Language：Japanese   Publisher：Japanese Society of Psychosomatic Medicine  

The purpose of this study was to explore the factor structure of the Japanese version of Interpersonal Sensitivity Measure (J-IPSM). The J-IPSM assesses the tendency for being sensitive to rejection (interpersonal rejection sensitivity). This study comprised 301 undergraduate students who completed the J-IPSM. The J-IPSM included 27 items loading on 5 factors - "fear of breakup of a relationship", "unassertive interpersonal behavior due to fear of hurting others", "fear of criticism by others", "discrepancy between social self-image and true self-image", and "obsequence to others". The internal consistency of the scale and each subscale explored by the factor analysis were suffi-ciently high (α=0.78-0.91). Furthermore, among atypical depressive patients, the scores of J-IPSM correlated strongly with the score of the self-reported measures of depressive symptoms. The J-IPSM, therefore, may be highly valid and potential for clinical and research applications. Finally, differences in the results of original IPSM and J-IPSM were discussed from the viewpoint of culture.

DOI： 10.15064/jjpm.54.5_422

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Other Link： http://search.jamas.or.jp/link/ui/2014240618

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jad.2013.05.067

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Language：Japanese   Publisher：(一社)日本認知・行動療法学会  

DOI： 10.24468/jjbt.38.1_35

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J00454&link_issn=&doc_id=20120229100004&doc_link_id=10.24468%2Fjjbt.38.1_35&url=https%3A%2F%2Fdoi.org%2F10.24468%2Fjjbt.38.1_35&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Total pages：viii, 221p   Language：Japanese

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Language：Japanese   Publisher：The Japanese Psychological Association  

DOI： 10.4992/pacjpa.89.0_442

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Language：Japanese   Publisher：The Japanese Psychological Association  

DOI： 10.4992/pacjpa.89.0_595

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Publishing type：Meeting report  

J-GLOBAL

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Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper, summary (international conference)  

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Language：Japanese   Publishing type：Meeting report  

J-GLOBAL

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Language：Japanese   Publisher：(一社)日本認知・行動療法学会  

J-GLOBAL

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Publishing type：Research paper, summary (national, other academic conference)  

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Authorship：Lead author   Language：Japanese   Publishing type：Meeting report   Publisher：日本慢性疼痛学会  

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J-GLOBAL

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Language：Japanese   Publisher：(国研)国立精神・神経医療研究センター精神保健研究所  

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Language：Japanese   Publisher：日本行動医学会  

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Language：Japanese   Publisher：日本認知療法・認知行動療法学会  

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Language：Japanese   Publisher：(公社)全国大学保健管理協会  

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Language：Japanese   Publisher：(一社)日本認知・行動療法学会  

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Language：Japanese   Publisher：(一社)日本認知・行動療法学会  

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Language：Japanese   Publisher：(一社)日本認知・行動療法学会  

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Language：Japanese   Publisher：(国研)国立精神・神経医療研究センター精神保健研究所  

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Language：Japanese   Publisher：日本生理心理学会  

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Language：Japanese   Publisher：(公社)日本精神神経学会  

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Language：Japanese   Publisher：(公社)日本精神神経学会  

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Language：Japanese   Publisher：(公社)全国大学保健管理協会  

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Authorship：Lead author   Language：Japanese   Publisher：産業医学振興財団  

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032400046

Authorship：Lead author   Language：Japanese   Publisher：(一社)日本産業精神保健学会  

J-GLOBAL

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Language：Japanese   Publisher：(公社)日本精神神経学会  

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Language：Japanese   Publisher：広島医学会  

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Language：Japanese   Publisher：(一社)日本産業精神保健学会  

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Language：Japanese   Publisher：(公社)全国大学保健管理協会  

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Language：Japanese   Publisher：(有)科学評論社  

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Language：Japanese   Publisher：Japanese Society for Medical and Biological Engineering  

Since the COVID-19 pandemic has further increased depression and suicide, the development of its neuroscience-based therapeutic method is urgently required. In our fMRI studies of depressed patients, we found that the hyperfunction of dorsolateral prefrontal cortex (DLPFC) which related loss of motivation, while hypofunction of posterior cingulate (PCC) which related rumination, and these were improved by antidepressant. Focusing on the antagonistic effect between DLPFC and PCC, we carried out a clinical trial of fMRI neurofeedback (NF) targeting DLPFC. We found its antidepressive effect and suggested a potent non-pharmacological treatment for depression. Next, in order to develop a more practical NF treatment for depression, fNIRS-NF targeting DLPFC was carried out on healthy subjects evaluating by the Beck depression inventory (BDI) and rumination-reflection questionnaire (RRQ) as well as its safety and brain functional change by fMRI. In this session, we will introduce our research and discuss the future prospects of fNIRS.

DOI： 10.11239/jsmbe.annual59.246

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Language：Japanese   Publisher：日本生物学的精神医学会  

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Language：Japanese   Publisher：(株)金剛出版  

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Language：Japanese   Publisher：(株)金剛出版  

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Language：Japanese   Publisher：(公社)全国大学保健管理協会  

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Language：Japanese   Publisher：日本認知療法学会  

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Language：Japanese   Publisher：(株)学樹書院  

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Language：Japanese   Publisher：(公社)全国大学保健管理協会  

J-GLOBAL

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Language：Japanese   Publisher：(公財)日本精神衛生会  

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Language：Japanese  

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Language：Japanese   Publisher：(株)中外医学社  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本認知・行動療法学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J06546&link_issn=&doc_id=20181212310065&doc_link_id=10.24468%2Fjabctc.44.0_160&url=https%3A%2F%2Fdoi.org%2F10.24468%2Fjabctc.44.0_160&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(公社)日本心理学会  

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

J-GLOBAL

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J-GLOBAL

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

J-GLOBAL

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Authorship：Lead author   Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Authorship：Lead author   Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

J-GLOBAL

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

J-GLOBAL

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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J-GLOBAL

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Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Language：Japanese   Publisher：早稲田大学人間科学学術院  

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Other Link： http://hdl.handle.net/2065/39387

Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J05371&link_issn=&doc_id=20121129160175&doc_link_id=%2Fdr4beabs%2F2012%2F0038s1%2F164%2F0388-0389%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdr4beabs%2F2012%2F0038s1%2F164%2F0388-0389%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J05371&link_issn=&doc_id=20121129160145&doc_link_id=%2Fdr4beabs%2F2012%2F0038s1%2F134%2F0328-0329%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdr4beabs%2F2012%2F0038s1%2F134%2F0328-0329%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Authorship：Lead author   Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J05371&link_issn=&doc_id=20121129160143&doc_link_id=%2Fdr4beabs%2F2012%2F0038s1%2F132%2F0324-0325%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdr4beabs%2F2012%2F0038s1%2F132%2F0324-0325%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J05371&link_issn=&doc_id=20121129160142&doc_link_id=%2Fdr4beabs%2F2012%2F0038s1%2F131%2F0322-0323%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdr4beabs%2F2012%2F0038s1%2F131%2F0322-0323%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J05371&link_issn=&doc_id=20120117240061&doc_link_id=%2Fdr4beabs%2F2011%2F0037s1%2F054%2F0188-0189%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdr4beabs%2F2011%2F0037s1%2F054%2F0188-0189%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J05371&link_issn=&doc_id=20120117240109&doc_link_id=%2Fdr4beabs%2F2011%2F0037s1%2F102%2F0286-0287%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdr4beabs%2F2011%2F0037s1%2F102%2F0286-0287%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J05371&link_issn=&doc_id=20120117240060&doc_link_id=%2Fdr4beabs%2F2011%2F0037s1%2F053%2F0186-0187%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdr4beabs%2F2011%2F0037s1%2F053%2F0186-0187%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Authorship：Lead author   Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J05371&link_issn=&doc_id=20120117240206&doc_link_id=%2Fdr4beabs%2F2011%2F0037s1%2F198%2F0480-0481%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdr4beabs%2F2011%2F0037s1%2F198%2F0480-0481%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Event date： 2023.12

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2023.10

Language：Japanese   Presentation type：Symposium, workshop panel (public)  

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Event date： 2022.11

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2022.9 - 2022.10

Language：Japanese   Presentation type：Symposium, workshop panel (public)  

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Event date： 2022.3

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Event date： 2021.7

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2021.6

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2020.9

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2020.9

Language：Japanese   Presentation type：Symposium, workshop panel (public)  

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Event date： 2018.10

Language：Japanese  

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Event date： 2018.8

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Event date： 2018.8

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Audience： Teachers,　Governmental agency

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Audience： High school students

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Audience： Researchesrs,　General

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