Updated on 2026/05/26
修士（生命科学） ( 2014.3 東京大学 )
学士（生物学） ( 2012.3 広島大学 )
Niigata University Graduate School of Medical and Dental Sciences Assistant professor
2026.4
Niigata University Graduate School of Medical and Dental Sciences Research assistant
2025.8 - 2026.3
Country：Japan
RIKEN Center for Brain Science Research Associate
2019.9 - 2022.3
Gunma University Institute for Molecular and Cellular Regulation Researcher
2018.4 - 2019.8
Japan Society for the Promotion of Science Research Fellowship for Young Scientists
2016.4 - 2018.3
Niigata University Graduate School of Medical and Dental Sciences Specially Appointed Assistant Professor
2026.4
The University of Tokyo Graduate School of Medicine Functional Biology
2014.4 - 2020.3
Country： Japan
The University of Tokyo Graduate School of Frontier Sciences Department of Medical Genome Sciences
2012.4 - 2014.3
Country： Japan
Hiroshima University Faculty of Science Faculty of Biology
2008.4 - 2012.3
Country： Japan
Molecular Biology Society of Japan
2025.12
生化学若い研究者の会 生命科学夏の学校 運営委員（第52回〜第54回）
2012.4 - 2014.3
Optogenetics: Applications in psychiatric research Reviewed
Fukutoshi Shirai, Akiko Hayashi‐Takagi
Psychiatry and Clinical Neurosciences 71 ( 6 ) 363 - 372 2017.3
Abnormal intrinsic dynamics of dendritic spines in a fragile X syndrome mouse model in vivo Reviewed
Akira Nagaoka, Hiroaki Takehara, Akiko Hayashi-Takagi, Jun Noguchi, Kazuhiko Ishii, Fukutoshi Shirai, Sho Yagishita, Takanori Akagi, Takanori Ichiki, Haruo Kasai
Scientific Reports 6 ( 1 ) 2016.5
Labelling and optical erasure of synaptic memory traces in the motor cortex Reviewed
Akiko Hayashi-Takagi, Sho Yagishita, Mayumi Nakamura, Fukutoshi Shirai, Yi I. Wu, Amanda L. Loshbaugh, Brian Kuhlman, Klaus M. Hahn, Haruo Kasai
Nature 525 ( 7569 ) 333 - 338 2015.9
実験医学opinion：「伝える」から「伝わる」科学報道へ
白井福寿, 山元孝佳, 馬谷千恵, 村山知, 有馬陽介（ Role： Joint author , 実験医学opinion 第52回）
羊土社 2014.10 （ ISBN:9784758101325 ）
実験医学opinion：第49回指導教員が移動! さぁどうする?
白井福寿, 豊田優（ Role： Joint author , 実験医学opinion 第49回）
羊土社 2014.7 （ ISBN:9784758101295 ）
Establishment of a new technology for visualizing and optically manipulating spines associated with memory
Fukutoshi Shirai, Akiko Hayashi, Takagi
The Japanese Society for Neurochemistry, Neurochemistry Topics 2016.5
Investigation of effect on the extra-large dendritic spine to neuronal firing
Grant number：20K15908
2020.4 - 2022.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Early-Career Scientists
Awarding organization：Japan Society for the Promotion of Science
Shirai Fukutoshi
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
Neurons receive inputs from a lot of other neurons via dendritic spines. And dendritic computation and neuronal firing occur. However, how spine size affects the dendritic and somatic events is unknown. To investigate their relationships, we combined glutamate uncaging, imaging, and electrophysiological technics. And we found small and large spines have different effects on dendritic computation and neuronal firing even if we stimulated the same numbers of spines. Futhermore, the stimulation to only a few extra-large spines could induce firing. It suggests that extra-large spines could interfere with functioning as a coincidence detector.
The longitudinal and quantitative study of neurons in dying brain for postmortem study
Grant number：19K23937
2019.8 - 2021.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Research Activity Start-up
Awarding organization：Japan Society for the Promotion of Science
Fukutoshi shirai
Grant amount：\2860000 （ Direct Cost: \2200000 、 Indirect Cost：\660000 ）
The postmortem brain study is important to investigate the micro-scale pathophysiology in the human brain of patients with mental disorders. However, it is unclear whether the knowledge from the postmortem brain study reflects the pathophysiology while alive or the secondary effect after death. In this study, we investigated the morphological changes of dendrites and dendritic spines in living mouse brains by two-photon in vivo imaging and continued this imaging after euthanasia. The results suggest that dendrite and dendritic spine morphology don’t change uniformly after death. And relatively large dendritic spines tend to keep their shapes compared to dendrites.
マウス胎児への子宮内エレクトロポレーション法 講習（群馬大学内における研究技術普及活動、講師）
Graduate Program for Leaders in Life Innovation（GPLLI）
無料学習会 運営補助員
Role(s)： Lecturer, Organizing member
NPO法人ひこばえ 2018 - 2019
てんとう虫の会 運営支援員
Role(s)： Organizing member
公益財団法人日本ダウン症協会 2012 - 2013
科学実験講座（小学校)）運営支援員
Role(s)： Organizing member, Demonstrator
広島大学教育学部 2011
