Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (international conference proceedings)  

DOI： 10.1007/s00520-023-07786-4

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PURPOSE: Oral mucositis is a severe adverse event in patients with head and neck cancer (HNC) receiving chemotherapy and radiotherapy that may cause the termination of cancer treatment. In this study, we aimed to reveal the benefits of pharmacist interventions in oral health care for patients with HNC receiving concurrent chemoradiotherapy (CCRT). METHODS: We conducted a multicenter, prospective cohort study on 173 patients from September 2019 to August 2022. We evaluated the association between the occurrence of oral mucositis during CCRT and various factors in the absence or presence of direct medication instructions from hospital pharmacists. RESULTS: Sixty-eight patients received medication instructions from pharmacists (the pharmacist intervention group), whereas 105 patients did not receive instructions (the control group). Logistic regression analysis showed that grade 2 (Gr 2) oral mucositis was significantly lower in patients receiving pharmacist interventions than in patients in the control group (adjusted odds ratio [aOR], 0.42; 95% confidence interval [CI], 0.18-0.96; P = 0.04). The time to onset of Gr 2 oral mucositis was significantly longer in the pharmacist intervention group than in the control group (hazard ratio, 0.53; 95% CI, 0.29-0.97; P = 0.04). CONCLUSION: Direct intervention, especially when provided by hospital pharmacists, can have a real effect in supporting patients with HNC experiencing severe side effects of treatments. Moreover, the integration of pharmacists into the oral healthcare team is becoming even more essential to reduce the severity of side effects.

DOI： 10.1007/s00520-023-07784-6

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Language：Japanese   Publisher：新潟医学会  

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

(1) Background: The impacts of metal artifacts (MAs) on the contouring workload for head and neck radiotherapy have not yet been clarified. Therefore, this study evaluated the relationship between the contouring time of the MAs area and MAs on head and neck radiotherapy treatment planning. (2) Methods: We used treatment planning computed tomography (CT) images for head and neck radiotherapy. MAs were classified into three severities by the percentage of CT images containing MAs: mild (<25%), moderate (25–75%), and severe (>75%). We randomly selected nine patients to evaluate the relationship between MAs and the contouring time of the MAs area. (3) Results: The contouring time of MAs showed moderate positive correlations with the MAs volume and the number of CT images containing MAs. Interobserver reliability of the extracted MAs volume and contouring time were excellent and poor, respectively. (4) Conclusions: Our study suggests that the contouring time of MAs areas is related to individual commitment rather than clinical experience. Therefore, the development of software combining metal artifact reduction methods with automatic contouring methods is necessary to reducing interobserver variability and contouring workload.

File： tomography-09-00009 (1).pdf

DOI： 10.3390/tomography9010009

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: Side-effects of medications cause xerostomia. There have been cases where a medication has been discontinued owing to its severe side-effects. Therefore, the xerostomia must be treated to ensure that the primary disease is managed effectively. This study analyzed the actual status of patients with medication-induced xerostomia and investigates factors associated with its improvement. METHODS: This study assessed 490 patients diagnosed with medication-induced xerostomia who had an unstimulated salivary flow of ≤0.1 mL/min and received treatment for xerostomia at a xerostomia clinic. Patient age, sex, medical history, medications used, disease duration of xerostomia, and psychological disorders were recorded. The anticholinergic burden was assessed using the Anticholinergic Cognitive Burden scale. The unstimulated salivary flow was measured by the spitting method. According to their symptoms and diagnoses, the patients were introduced to oral lubricants, instructed on how to perform massage, and prescribed Japanese herbal medicines, and sialogogues. Factors associated with the subjective improvement of xerostomia and objective changes in the salivary flow rate were recorded at six months. RESULTS: Xerostomia improved in 338 patients (75.3%). The improvement rate was significantly lower in patients with psychiatric disorders (63.6%) (P = 0.009). The improvement rate decreased as more anticholinergics were used (P = 0.018). However, xerostomia improved in approximately 60% of patients receiving three or more anticholinergics. The unstimulated salivary flow increased significantly more in patients who reported an improvement of xerostomia (0.033±0.053 mL/min) than in those who reported no improvement (0.013±0.02 mL/min) (P = 0.025). CONCLUSION: Xerostomia treatment improved oral dryness in 75.3% of patients receiving xerogenic medications in this study. If xerostomia due to side-effects of medications can be improved by treatment, it will greatly contribute to the quality of life of patients with xerogenic medications and may reduce the number of patients who discontinue medications.

DOI： 10.1371/journal.pone.0280224

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Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.11242/dentalradiology.61.41

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Oral and Maxillofacial Radiology  

DOI： 10.11242/dentalradiology.61.53

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/osi2.1129

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/osi2.1129

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: This study aimed to clarify the accuracy of intraoral ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) in preoperative image depth of invasion (DOI) measurement of T1/T2 tongue cancer through comparison with histopathological measurements. METHODS: Imaging of the primary lesions was performed at our hospital; the lesions were classified into T1 and T2 based on the 8th edition of the AJCC/UICC, and surgery performed. There was histopathological confirmation of lesions as squamous cell carcinoma in 48 patients with tongue cancer. T3 and T4 cases, cases in which preoperative chemotherapy and radiation therapy were performed, and cases where biopsy was performed before imaging were excluded. The radiological DOI in US, CT, and MRI and the histopathological DOI as base were comparatively investigated and statistical analyses were performed by Bland-Altman analysis and Spearman's rank correlation coefficient. RESULTS: Bland-Altman analysis showed that the US radiological DOI was overestimated by an average of 0.2 mm compared to the histopathological DOI, while CT and MRI radiological DOI were overestimated by an average of 2-3 mm. The comparison of CT and MRI revealed that the difference between the MRI and histopathological DOI, as well as the 95% limit of agreement, were smaller than those of the CT radiological DOI. CONCLUSIONS: US is the most accurate preoperative diagnostic tool for T1 and T2 squamous cell carcinoma; CT and MRI tend to have an overestimation of about 2-3 mm and so caution is required.

DOI： 10.1007/s11282-021-00533-7

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

PURPOSE: Bloodstream infection (BSI) is a major complication of allogeneic hematopoietic stem-cell transplantation (allo-SCT). There are several causes of BSI; in particular, severe oral mucositis (OM) can induce BSI due to coagulase-negative staphylococci (CoNS). The OM severity may be reduced with intensive oral care. Thus, we evaluated whether the type of oral care affects the BSI incidence eventually. METHOD: We performed retrospective analysis on 206 recipients who underwent allo-SCT from 2006 to 2017 at our institute. Intensive oral care by a dental specialist was performed for 111 recipients (intensive-care group) and self-oral care was performed by 95 recipients (self-care group). Incidence of BSI was assessed by type of the oral care, before neutrophil engraftment (pre-E-BSI) and after neutrophil engraftment (post-E-BSI) period until 180 days after allo-SCT. RESULT: A total of 112 BSI occurred in 90 of the 206 recipients and 120 bacteria were identified, with CoNS being the most prevalent. There was no significant difference in the incidence of pre-E-BSI between the self-care and intensive-care groups (30.8% and 30.6%, respectively; P = 0.508). Meanwhile, the incidence of post-E-BSI was significantly lower in the intensive-care group than in the self-care group (14.3% and 28.6%; P = 0.008). In addition, the intensive-care group had significantly lower incidence of post-E-BSI with CoNS than the self-care group (8.5% and 21.5%, respectively; P = 0.009). CONCLUSION: Intensive oral care through the period of allo-HCT can significantly reduce the post-E-BSI occurrence, especially due to CoNS.

DOI： 10.1007/s00520-021-06447-8

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Other Link： https://link.springer.com/article/10.1007/s00520-021-06447-8/fulltext.html

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Public Library of Science (PLoS)  

<sec id="sec001">
<title>Objectives</title>
This retrospective study examined how a pharmacist-involved education program in a multidisciplinary team (PEMT) for oral mucositis (OM) affected head-and-neck cancer (HNC) patients receiving concurrent chemoradiotherapy (CCRT).


</sec>
<sec id="sec002">
<title>Materials and methods</title>
Total samples data of 53 patients during the stipulated timeframe were retrospectively collected from electronic medical records from February 2017 to January 2019. We compared the presence/absence of OM (OM: yes/no) between patients with and without PEMT (PEMT: yes/no) as the primary endpoint and OM severity as the secondary endpoint. The following information was surveyed: age, gender, weight loss, steroid or immunosuppressant use, hematological values (albumin, white blood cell count, blood platelets, and neutrophils), cancer grade, primary cancer site, type and use of mouthwash and moisturizer, opioid use (yes/no, days until the start of opioid use, and dose, switch to tape), and length of hospital day (LOD). The two groups were compared using Fisher’s exact test for qualitative data and the Mann-Whitney U test for quantitative data, and a significance level of <italic>p&lt;0</italic>.<italic>05</italic> was set.


</sec>
<sec id="sec003">
<title>Results</title>
The group managed by PEMT had significantly lower weight loss and a significantly lower incidence of local anesthetic and opioid use and switch to tape compared with the group not managed by PEMT (<italic>p&lt;0</italic>.<italic>05</italic>). The two groups showed no significant difference in OM (yes/no) or OM severity. The PEMT group had significantly shorter LOD at 57 (53–64) days compared with the non-PEMT group at 63.5 (57–68) days (<italic>p&lt;0</italic>.<italic>05</italic>).


</sec>
<sec id="sec004">
<title>Conclusions</title>
Our results showed that PEMT did not improve OM (yes/no) or OM severity in HNC patients undergoing CCRT. However, the PEMT group had a lower incidence of grades 3 and 4 OM than the non-PEMT group, although not significantly. In addition, PEMT contributed to oral pain relief and the lowering of the risk for OM by reduction in weight loss.


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File： journal.pone.0260026.pdf

DOI： 10.1371/journal.pone.0260026

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

The clinical features of xerostomia induced by immune checkpoint inhibitors (ICI) are similar to those of Sjögren's syndrome (SS), whereas the immunohistological and serological features are known to differ from those of SS. However, the radiologic imaging features of salivary glands are not yet well known. We report a case of a 56-year-old male patient diagnosed with ICI-induced xerostomia. The patient underwent various imaging examinations to investigate the condition of the salivary glands, which indicated the following: (1) less specific findings on contrast-enhanced computed tomography, (2) mixed with intermediate and low signal intensity on both T1-weighted and fat-suppressed T2-weighted magnetic resonance imaging and poor "salt and pepper" appearance on magnetic resonance sialography, and (3) multiple ovoid hypoechoic areas with hyperechoic bands without acute sialadenitis on ultrasound. These radiologic imaging findings suggested remarkable lymphocyte infiltration, which could be a characteristic of ICI-induced xerostomia.

File： s11282-020-00480-9 (3).pdf

DOI： 10.1007/s11282-020-00480-9

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s00520-021-06285-8

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Other Link： https://link.springer.com/article/10.1007/s00520-021-06285-8/fulltext.html

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

R2TP is a well-conserved molecular chaperone complex, composed of Pontin, Reptin, RPAP3, and PIH1D, in eukaryotes. Recent studies have suggested an involvement of R2TP in cancer development. However, it remains unclear if it is related to the development of oral squamous cell carcinoma (OSCC), which is the most common type of oral cancer. Here, we identify and investigate the function of R2TP in OSCC development. Immunohistochemical analysis reveals that all of the R2TP components are strongly expressed in normal oral epithelia and OSCC tissues, where actively proliferating cells are abundant. Co-immunoprecipitation assay identifies that R2TP components form a protein complex in OSCC-derived HSC4-cells. Knockdown experiments show that all R2TP components, except for RPAP3, are required for the cell proliferation and migration of HSC-4 cells. Furthermore, we reveal that Pontin contributes to a gain-of-function (GOF) activity of mutp53-R248Q in HSC-4 cells by regulating phosphorylation levels of mutp53 at Ser15 and Ser46. To our knowledge, this study is the first to report the functional involvement of R2TP and its components in the malignant characteristics of OSCC cells.

DOI： 10.1016/j.bbrc.2021.02.074

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/osi2.1110

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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ABSTRACT: The purpose of the present study was to investigate the efficacy of perioperative oral managements (POMs) on perioperative nutritional conditions in patients undergoing surgery with general anesthesia. Medical records were retrospectively reviewed and the effects of POMs were investigated based on a large number of cases using a multicenter analysis. The profile of serum albumin levels was assessed and compared between patients with and without POMs using the multivariate analysis. Seventeen Eleven thousand and one hundred sixty patients (4,873 males and 6,287 females) were reviewed. Of these, 2710 patients (24.3%) had undergone POMs. The results of a multivariate analysis revealed the significant positive effect of POMs on perioperative serum albumin level (change between at admission and discharge, (Estimate: 0.022, standard error: 0.012, P < .0001). Patient gender, age, surgical site, performance status, the American Society of Anesthesiologists (ASA) physical status classification, operation time, amount of blood loss, and serum albumin level at admission were also significant predictors. Adjusted multivariate analysis of the effects of POMs on perioperative change of serum albumin level in all subjects reveled the significance of POMs intervention (estimate: 0.022, standard error: 0.012, P < .0001). These results suggest that POMs exerts significant positive effects on perioperative serum albumin levels in patients underwent surgery under general anesthesia.

File： the_effects_of_perioperative_oral_management_on.103 (1).pdf

DOI： 10.1097/MD.0000000000025119

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

The aim of this study was to compare the estimated public medical care cost of measures to address metallic dental restorations (MDRs) for head and neck radiotherapy using high-energy mega-voltage X-rays. This was considered a first step to clarify which MDR measure was more cost-effective. We estimated the medical care cost of radiotherapy for two representative MDR measures: (i) with MDR removal or (ii) without MDR removal (non-MDR removal) using magnetic resonance imaging and a spacer. A total of 5520 patients received head and neck radiation therapy in 2018. The mean number of MDRs per person was 4.1 dental crowns and 1.3 dental bridges. The mean cost per person was estimated to be 121 720 yen for MDR removal and 54 940 yen for non-MDR removal. Therefore, the difference in total public medical care cost between MDR removal and non-MDR removal was estimated to be 303 268 800 yen. Our results suggested that non-MDR removal would be more cost-effective than MDR removal for head and neck radiotherapy. In the future, a national survey and cost-effectiveness analysis via a multicenter study are necessary; these investigations should include various outcomes such as the rate of local control, status of oral mucositis, frequency of hospital visits and efforts of the medical professionals.

File： rrab003.pdf

DOI： 10.1093/jrr/rrab003

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

新潟大学医歯学総合病院医療連携口腔管理チームは、2020年4月から医療連携口腔管理治療部として活動を行っている。今回、活動実態の把握と今後の課題を明らかにすることを目的に実態調査を行ったのでその結果を報告する。対象は2013年1月〜2020年6月の期間に当チームおよび当治療部を受診した患者とした。診療録および診療台帳を基に患者数、依頼目的、原疾患の診療科などを後方視的に調査・検討した。調査期間における新患数は4,077人で、その数は経年的に増加していた。依頼目的は感染予防が最も多く、年々増加していた。粘膜炎対応、顎骨壊死予防・対応は増加ののち、一定数で推移していた。原疾患の診療科は耳鼻咽喉・頭頸部外科が最も多く、ついで、腎・膠原病内科、呼吸器感染症内科、腫瘍内科、血液内科であった。新患数は年々増加していたが、周術期等口腔機能管理での介入が求められる全症例への介入には至っていなかった。今後は、介入対象の拡大に向け、より効率的な診療体制と病院内での協力体制の構築、地域医療機関との連携が必要であると考える。(著者抄録)

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

Background and purpose: Concurrent chemoradiotherapy (CCRT) for head and neck cancer (HNC) is a risk factor for oral candidiasis (OC). As Candida spp. are highly virulent, we conducted a retrospective study to determine whether OC increases the severity of dysphagia related to mucositis in HNC patients. Patients and methods: We retrospectively analyzed the cases of consecutive patients with carcinomas of the oral cavity, pharynx, and larynx who underwent CCRT containing cisplatin (CDDP) at our hospital. The diagnosis of OC was based on gross mucosal appearance. We performed a multivariate analysis to determine whether OC was associated with the development of grade 3 dysphagia in the Radiation Therapy Oncology Group (RTOG) Acute Toxicity Criteria. The maximum of the daily opioid doses was compared between the patients with and without OC. Results: We identified 138 HNC patients. OC was observed in 51 patients (37%). By the time of their OC diagnosis, 19 (37%) had already developed grade 3 dysphagia. Among the 30 patients receiving antifungal therapy, 12 (40%) showed clinical deterioration. In the multivariate analysis, OC was independently associated with grade 3 dysphagia (OR 2.75; 95%CI 1.22-6.23; p = 0.015). The patients with OC required significantly higher morphine-equivalent doses of opioids (45 vs. 30 mg/day; p = 0.029). Conclusion: Candida infection causes refractory dysphagia. It is worth investigating whether antifungal prophylaxis reduces severe dysphagia related to candidiasis.

File： s11282-020-00480-9 (3).pdf

DOI： 10.1016/j.ctro.2019.10.006

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OBJECTIVE: Recent data indicated that concurrent chemoradiotherapy (CCRT) using high dose cisplatin (CDDP) is the most useful treatment for advanced head and neck squamous cell carcinoma (SCC). Regarding the dose of CDDP, 100mg/m2 is most recommended in Western countries. However, in terms of a balance of efficacy and adverse events, appropriate dose of cytotoxic drugs such as CDDP may be different among the different ethnic groups. In this multicenter phase I/II study, we aimed to identify the optimal dose of CDDP in CCRT for patients with advanced head and neck SCC in the Japanese. METHODS: Patients were eligible for inclusion if they had head and neck SCC that was treated with radical CCRT comprising whole-neck irradiation of the primary lesion and level II-IV lymph nodes on both sides. For the phase I study, a CDDP dose was 70mg/m2 for level 0, 80mg/m2 for level 1, and 100mg/m2 for level 2. Maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) were examined by phase I trial, by which CDDP dose for phase II was determined. The primary endpoint for the phase II was CCRT completion rate, and the secondary endpoint was full-dose-CCRT completion rate, the percentage of patients receiving a total CDDP dose of ≥200mg/m2, response rate, and incidences of adverse events. RESULTS: A CDDP dose of 100mg/m2 was the MTD for phase I, and the recommended dose for phase II was 80 mg/m2. Forty-seven patients were evaluated in the phase II trial. CCRT completion rate, full-dose-CCRT rate, and the percentage of patients receiving a total CDDP dose of ≥200mg/m2, were 93.6%, 78.7%, and 93.6%, respectively. One patient (2.1%) developed grade 2 renal dysfunction, and no patient developed febrile neutropenia or a grade 4 adverse event. CONCLUSION: The present phase I study indicated that a CDDP dose of 80mg/m2 is the optimal dose in terms of safety. The phase II study revealed that CCRT completion rate, response rate, and rates of adverse events were not inferior for a CDDP dose of 80mg/m2 as compared with a dose of 100mg/m2, and a dose of 80mg/m2 is therefore recommended in CCRT for the Japanese. This study was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR; identification No. UMIN000010369).

File： 1-s2.0-S0385814617309331-main.pdf

DOI： 10.1016/j.anl.2018.02.008

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(一社)日本摂食嚥下リハビリテーション学会  

口腔乾燥症の原因は、シェーグレン症候群(SS)、ストレス、薬剤の副作用など多岐にわたるうえ、原因は1つではない可能性がある。しかし、口腔乾燥症の診断基準は統一されておらず、医療機関あるいは歯科医師によって異なるのが現状である。また、従来のフローチャート形式の診断チャートでは、複数診断を行うことが困難である。著者らは、口腔乾燥症の診断を統一基準のもとで簡便に行うことを目的として、口腔乾燥症の診断基準を作成した。また、その診断基準をもとに、A4用紙1枚の診断チャートを作成した。その後、2014年1月から2016年12月に当科を受診した初診患者220名を対象として、診断チャートを用いた臨床統計を行った。診断の結果、自律神経性口腔乾燥症(135名、61.4%)が最も多く、次いで薬剤性(126名、57.3%)、蒸発性(81名、36.8%)、シェーグレン症候群(35名、15.9%)、心因性(歯科心身症)(32名、14.5%)であった。複数の歯科医師による診断の一致度は、カッパ係数が0.99で非常に高かった(p<0.001)。診断名が2つ以上ついている者は74.5%であった。今回、口腔乾燥症には、複数の要因が関連している可能性が高いことが明らかになった。今後、口腔乾燥症の診断にあたっては、複数診断が可能な口腔乾燥症診断チャートを使用することが有用であると考えられる。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J03152&link_issn=&doc_id=20190416130007&doc_link_id=%2Fcb5dvsph%2F2018%2F002202%2F007%2F0153-0160%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcb5dvsph%2F2018%2F002202%2F007%2F0153-0160%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：OXFORD UNIV PRESS  

DOI： 10.1093/annonc/mdx583

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

The aim of this study was to estimate the clinical significance of using intraoral strain elastography to establish an early diagnosis of tongue carcinoma.A total of 17 patients (11 men, 6 women; median age 67 years; age range 38-85 years) with a tumorous lesion of the tongue suggesting that early stage tongue carcinoma were enrolled in the study. Intraoral strain elastography was performed with a small hockey stick-shaped intraoperative probe and acoustic coupling polymer gel. The elasticity of the lesions was classified into four grades, with a score of 1 indicating a very soft tissue and a score of 4 indicating a very hard tissue. The patients were divided into two groups based on the histopathologically verified malignancy: carcinoma group (n = 15) and non-malignancy group (n = 2).All patients underwent surgical resection and histopathological examination of the surgical specimen. The pathology in the carcinoma group included 12 cases of squamous cell carcinoma and three cases of carcinoma in situ. The pathology in the non-malignancy group included one case of viral stomatitis and one case of pyogenic granuloma. The elasticity score was limited to 3 or 4 in the carcinoma group and 1 or 2 in the non-malignancy group. There was no significant difference in the elasticity scores between squamous cell carcinoma and carcinoma in situ.Although limited by the small number of subjects, the present results suggest that intraoral strain elastography could be an alternative noninvasive method for diagnosing tongue carcinoma.

File： s11282-016-0269-1.pdf

DOI： 10.1007/s11282-016-0269-1

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY  

AIM: We hypothesized that feeling mucosal dryness in one body region and the skin may be associated with dryness in other regions and that there are common background factors for dryness. In an earlier web-based survey, we reported prevalence figures of dry eyes, nose, mouth, skin, and vagina. In the present study, additional analyses were made to investigate the factors associated with dryness in each region, and simultaneous dryness in multiple regions. METHODS: A web-based questionnaire was completed by 310 Japanese women. The questions included dryness of the eyes, nose, mouth, vagina, and skin. Menopausal and other symptoms were also addressed. Multiple logistic regression modeling was performed to identify factors associated with dryness in each region and in multiple dry regions. RESULTS: Dry eyes were associated with dryness in the nose and with headache; dry nose was associated with dryness in the vagina and eyes; dry mouth was associated with sticky mouth symptom and dryness of the nose; dry skin was associated with use of xerogenic medications and vaginal discharge; and dryness of the vagina was associated with vaginal itchiness and dry nose. Vaginal discharge (odds ratio, 9.64; 95% confidence interval, 3.15-29.51) and sticky mouth (odds ratio, 6.35; 95% confidence interval, 1.29-31.29) were further associated with dryness in multiple regions. CONCLUSION: The present results confirmed our study hypothesis by showing that dryness in one region was clearly associated with that in another or in multiple regions. The result implies the need for holistic diagnosis and counseling for patients with dryness complaints.

DOI： 10.1111/jog.13290

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：OXFORD UNIV PRESS  

The changes in dose distribution caused by backscatter radiation from a common commercial dental alloy (Au-Ag-Pd dental alloy; DA) were investigated to identify the optimal material and thicknesses of a dental device (DD) for effective prevention of mucositis. To this end, 1 cm3 of DA was irradiated with a 6-MV X-ray beam (100 MU) in a field size of 10 × 10 cm2 using a Novalis TX linear accelerator. Ethylene vinyl acetate copolymer, polyolefin elastomer, and polyethylene terephthalate (PET) were selected as DD materials. The depth dose along the central axis was determined with respect to the presence/absence of DA and DDs at thicknesses of 1-10 mm using a parallel-plate ionization chamber. The dose in the absence of DDs showed the lowest value at a distance of 5 mm from the DA surface and gradually increased with distance between the measurement point and the DA surface for distances of ≥5 mm. Except for PET, no significant difference between the DA dose curves for the presence and absence of DDs was observed. In the dose curve, PET showed a slightly higher dose for DA with DD than for DA without DD for thicknesses of ≥4 mm. The findings herein suggest that the optimal DD material for preventing local dose enhancement of the mucosa caused by DA backscatter radiation should have a relatively low atomic number and physical density and that optimal DD thickness should be chosen considering backscatter radiation and percentage depth dose.

File： rrw092.pdf

DOI： 10.1093/jrr/rrw092

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(一社)日本口腔ケア学会  

当院では2012年4月からSystematic Oral Management(以下OM)介入を開始した。今回、2010年3月〜2013年8月に高度無菌治療部で同種造血幹細胞移植を受けた患者26例を対象とし、OM介入開始前の群(非介入群13例)とOM介入群(13例)に分け、口腔粘膜炎(以下;粘膜炎)の発生率・重篤度・病悩期間を群間比較した。粘膜炎の評価には有害事象共通用語規準v4.0日本語訳JCOG版を改変したものを用いた。粘膜炎の発生率に群間差は認められず両群とも100%であったが、Grade 3〜4粘膜炎の発生率をみるとOM非介入群85%、介入群54%で介入群が有意に低かった。病悩期間の中央値は非介入群19.6日、介入群13.1日で介入群が有意に短かった。OMの具体的な内容を紹介した。

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

Objectives This study evaluated the effects of combined topical sodium fluoride and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste application on root surface conditions in cancer patients undergoing head and neck radiotherapy.Patients and methods Nineteen patients undergoing conventional external radiotherapy in head and neck cancer were enrolled and divided into CPP-ACP (topical sodium fluoride/daily CPP-ACP paste application) and Non-CPP-ACP (topical fluoride application alone) groups. Chronological root surface texture changes were prospectively investigated for 1 year.Results The mean radiation dose of the parotid gland did not differ significantly between the CPP-ACP and Non-CPP-ACP groups. From baseline to 6 and 6-12 months, the CPP-ACP group had significantly better root surface textures than those in the Non-CPP-ACP group (p = 0.001 and p < 0.001, respectively). The hard surface numbers in the CPP-ACP group increased from 347 to 350 in 12 months. The respective soft lesion incidence rates from baseline to 6, 6-12, and baseline to 12 months were significantly lower in the CPP-ACP group than those in the Non-CPP-ACP group (per patient: p = 0.038, p = 0.038, and p = 0.029; per root surface: p = 0.026, p < 0.001, and p < 0.001).Conclusions The present results suggest that dental management with a combination of topical sodium fluoride and CPP-ACP paste application can control root surface caries more effectively than topical sodium fluoride alone in patients undergoing head and neck radiotherapy.

File： s11282-015-0218-4.pdf

DOI： 10.1007/s11282-015-0218-4

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：HINDAWI LTD  

Most cases of hypophosphatasia (HPP) exhibit early loss of primary teeth. Results of microcomputed tomography (micro-CT) analysis of teeth with HPP have rarely been reported. The purpose of the present study was to describe the mineral density distribution and mapping of exfoliated teeth from an HPP patient using micro-CT. Four exfoliated teeth were obtained from a patient with HPP. Enamel and dentin mineral densities of exfoliated teeth were measured on micro-CT. The mean values of enamel and dentin mineral densities in mandibular primary central incisors with HPP were 1.61 and 0.98 g/cm3, respectively. The corresponding values in the mandibular primary lateral incisors were 1.60 and 0.98 g/cm3, respectively. Enamel hypoplasia was seen in the remaining teeth, both maxillary and mandibular primary canines and first and second molars. Micro-CT enables nondestructive, noninvasive evaluation and is useful for studying human hard tissues obtained from patients.

DOI： 10.1155/2016/4898456

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publisher：(一社)日本口腔ケア学会  

同種造血幹細胞移植治療において患者を最も苦しめる口腔有害事象は口腔粘膜炎で、治療関連死の一因である全身感染症を引起すことがある。口腔ケアを行うことにより、口腔粘膜炎の発生率の低減、重篤度の軽減、病悩期間の短縮が可能である。同種造血幹細胞移植治療の前処置から血球回復期の口腔粘膜炎対策を適切かつ効果的に行うための器質的口腔ケアの基礎知識について概説した。

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Society of Oral Diagnosis / Oral Medicine  

We investigated the relationship between oral care and candida species in 16 patients (14 men and 2 women) undergoing radiotherapy for head and neck cancer. They also received oral care by specialized dental staff. Candida species were detected in 12 patients (75% of all patients): <i>C. albicance</i> was detected in 8 cases (50%) and non-<i>C. albicance</i> was detected in 4 cases (25%). Advanced oral mucositis of more than grade 3 was seen in 13 patients, and candida species were detected in 11 cases.<br>Oral care in consideration of candida species is important because <i>C. albicance</i> and non-<i>C. albicance</i> were frequently detected in patients undergoing radiotherapy for head and neck cancer even though their oral condition was well maintained.

File： 27_1.pdf

DOI： 10.15214/jsodom.27.1

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Other Link： http://search.jamas.or.jp/link/ui/2014220823

Language：Japanese   Publisher：(一社)日本口腔衛生学会  

口腔乾燥症の診療では唾液分泌量を測定するが、その結果を記録するツールはほとんど見当たらない。また、他疾患の治療のための薬剤追加やストレスの原因となるイベント事象などは、唾液分泌量や乾燥感に大きな影響を与えるが、それらを記録するツールもない。したがって、症状の記録、患者-医療従事者間の情報共有、診療科間の情報共有、患者への情報提供、の4つを目的とした「ドライマウス手帳」を作成し、2012年4月に発行した。その後、医療従事者に対して、手帳のデザインや内容に関する無記名の質問紙調査を行った。質問紙調査の結果、手帳の大きさ、厚さ、文字の大きさ、唾液分泌量や症状の記入欄の大きさ、豆知識の情報量について「ちょうどよい」と回答した者はいずれも過半数を占めていた。改善点として挙げられたのは、常用薬剤の記入欄、症状のある部分を記入できる口腔内の図の掲載や、舌痛症や灼熱感などに関する情報提供などであったため、今後、手帳を改訂する際に検討したい。将来的には、口腔乾燥症と診断された患者すべてにドライマウス手帳を配布することで、患者-医療従事者間、医療従事者-医療従事者間の情報共有、患者自身の症状把握が進み、口腔乾燥症の診療の一助となればと考えている。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J00440&link_issn=&doc_id=20130808300003&doc_link_id=%2Fdk1dehea%2F2013%2F006304%2F003%2F0337-0343%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2013%2F006304%2F003%2F0337-0343%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

To investigate the possibility of predicting salivation ability using pulsed Doppler ultrasonography.Thirty healthy volunteers were enrolled in this study. The blood flow velocity in the submandibular gland before and during acid stimulation was recorded by pulsed Doppler ultrasonography. The changes in the maximum blood flow velocity (V (max)) and minimum blood flow velocity (V (min)) were analyzed and compared with the salivation abilities.Strong linear correlations between before and during acid stimulation were observed in the amount of salivation (R = 0.879, p < 0.05) and the V (max) (R = 0.938, p < 0.05). The mean change rate in the stimulated V (max) was 1.58 (range 1.10-4.58), and the mean (range) change rates in the V (max) after 1, 3, and 5 min of acid stimulation were 0.96 (0.47-1.47), 0.97 (0.79-1.40), and 0.98 (0.70-1.23), respectively. No strong linear correlation was observed between the amount of salivation and the blood flow velocity.Although it is known that an increase in the amount of salivation is closely related to an increase in the blood flow velocity in the salivary glands, our findings did not show a linear correlation between the amount of salivation and the blood flow velocity.

File： s11282-012-0102-4.pdf

DOI： 10.1007/s11282-012-0102-4

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Language：English   Publisher：Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo  

<b>Aim</b>: In dental treatment, to remove an instrument, such as dental mirror or to remove a dental cotton roll inserted in the gingivobuccal fold, often brings the patient discomfort or pain. To prevent these uncomfortable conditions, dental instruments or dental cotton rolls are moistened based on an empirical basis. However, there has been no research done evaluating whether discomfort is reduced by these techniques. The purpose of this study was to evaluate the effects of moistened techniques on the patientsʼ discomfort and the operatorsʼ ease. <b>Materials and Methods</b>: Thirty eight subjects without hyposalivation were studied. Two procedures were implemented. One was that a dry or moistened dental mirror was removed after exclusion of the buccal mucosa. The other was removal of a dental cotton roll from the gingivobuccal fold after either moistening it or leaving it dry. The subjectsʼcomfort and the operatorsʼ treatment ease were evaluated on five point scales. <b>Results</b>: During these procedures, the subjectsʼ comfort was significantly increased by moistening of both the dental mirror and the cotton roll. The ease of performing both procedures was also significantly increased for operators in the moistened condition. In addition, there was a significant positive correlation between the subjectsʼ comfort and the operatorsʼ ease. <b>Conclusion</b>: When using dental instruments and removing cotton rolls, moistening increases both the subjectsʼ comfort and operatorsʼ treatment ease.

DOI： 10.5466/ijoms.11.85

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Other Link： http://search.jamas.or.jp/link/ui/2014000129

Language：English   Publisher：Japanese Association for Oral Biology  

As societies age, the number of people complaining of dry mouth is increasing ', an estimated 30,000,000 people suffer from dry mouth in Japan. The mouth fulfills many basic human appetites, such as eating, drinking, tasting, and talking, and a core component of these functions is saliva. In this paper we will
(1) Explain what dry mouth is
(2) Introduce Niigata University Medical and Dental Hospital's dry mouth outpatient clinic '
(3) Describe a new diagnostic method using ultrasonic waves
and (4) Describe salivary protein analysis in patients suffering from Sjogren's syndrome (SS).

DOI： 10.2330/joralbiosci.53.31

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：BRITISH INST RADIOLOGY  

In this article we report a case of desmoplastic ameloblastoma in which chronological changes in the early development can be observed on dental radiographs. The tumour grew very slowly and did not appear to have a strong potential for local extension like typical ameloblastomas. Radiological findings of our case suggest the tumour arose from the periodontal membrane. However, it was not possible to obtain conclusive histopathological evidence. Dentomaxillofacial Radiology (2011) 40, 126-129. doi: 10.1259/dmfr/55423624

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DOI： 10.1259/dmfr/55423624

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

DOI： 10.1016/j.cca.2009.03.018

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

Purpose: To evaluate the significance of our dental management protocol by observing the chronological change of dental health of head and neck radiotherapy patients. Patients and Methods: Fifty-two head and neck radiotherapy patients who had received dental management to prevent and/or alleviate their oral complications were enrolled in this study. They were followed for three or more years after radiotherapy. We divided them into three groups according to the timing of the start of dental management
Pre, Mid and Post. The chronological changes of dental status (DMFT and the number of tooth extractions) and osteoradionecrosis were investigated for three to five years. Results: The increase in the DMFT index of the Pre and Mid groups was reduced to less than 2 by introducing our dental management protocol. On the contrary, the number of unavoidable tooth extractions following radiotherapy was the least in the Pre group. The incidence rates of osteoradionecrosis of the mandible in the Pre, Mid and Post groups were 6.5%, 18.0% and 20.0% respectively. Conclusion: Our dental management protocol was proved to be effective in maintaining dental health and helpful in controlling osteoradionecrosis following head and neck radiotherapy. For a more effective outcome, we advocate that dental management should commence before the start of head and neck radiotherapy. © 2009, Japan Society for Head and Neck Cancer. All rights reserved.

File： 35_266.pdf

DOI： 10.5981/jjhnc.35.266

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：MOSBY-ELSEVIER  

OBJECTIVE: Oral health status is a risk factor for postradiation bone complications (also known as osteoradionecrosis [ORN]), and oral health care is an important element in the prevention of this condition. Some authors recommend extracting teeth with a questionable prognosis and either gross mobility or periodontal disease. However, the criteria for making such decisions remain to be elucidated. In addition, the specific details of the association between oral health status and ORN have not yet been clearly demonstrated. The purpose of this study was to clarify the relationship between oral health status and the development of ORN. STUDY DESIGN: Thirty-nine head and neck cancer patients whose radiation fields included both the teeth and the mandible were followed for > or = 3 years after radiotherapy. Among these patients, 6 suffered from ORN (ORN group), and the other 33 did not experience the condition (non-ORN group). We analyzed the patient factors, radiation factors, and oral health factors related to the complication. RESULTS: The onset of ORN occurred from 18 months to 51 months after radiotherapy. The radiation dose in the oral cavity and the oral health status before radiotherapy were not significant risk factors for ORN. However, the oral health status at 1 year or 2 years after radiotherapy was significantly associated with the development of ORN. The oral health conditions that increased the risk of ORN were > 5 mm periodontal pocket depth, > 40% dental plaque score, > 60% alveolar bone loss level, and a grade 3 radiographic periodontal status. CONCLUSION: This is the first report to show the changes in the oral health status before and after radiotherapy regarding the development of ORN. The results support the periodontal status that almost all clinicians agree on as indications for preradiation teeth extraction (namely, periodontal pockets of > 5 mm) to prevent ORN. Good oral health status, especially after radiotherapy, is very important in the prevention of ORN, and we recommend periodical dental management and care by well trained dentists and dental hygienists to avoid the condition.

File： 1-s2.0-S1079210407008311-main.pdf

DOI： 10.1016/j.tripleo.2007.10.011

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：BMC  

BACKGROUND: Matrix metalloproteinase (MMP) is known to be involved in the initial and progressive stages of cancer development, and in the aggressive phenotypes of cancer. This study examines the association of single nucleotide polymorphisms in promoter regions of MMP-1 and MMP-3 with susceptibility to oral squamous cell carcinoma (OSCC). METHODS: We compared 170 Japanese OSCC cases and 164 healthy controls for genotypes of MMP-1 and MMP-3. RESULTS: The frequency of the MMP-1 2G allele was higher and that of the 1G homozygote was lower in the OSCC cases (p = 0.034). A multivariate logistic regression analysis revealed that subjects who were 45 years old or older had a significantly increased (2.47-fold) risk of OSCC (95%CI 1.47-4.14, p = 0.0006), and those carrying the MMP-1 2G allele had a 2.30-fold risk (95%CI 1.15-4.58, p = 0.018), indicating independent involvement of these factors in OSCC. One of the key discoveries of this research is the apparent reduction of the MMP-1 1G/1G and 1G/2G genotype distributions among the early onset OSCC cases under the ages of 45 years. It should be noted that the tongue was the primary site in 86.2% of these early onset cases. This could suggest the specific carcinogenic mechanisms, i.e. specific carcinogenic stimulations and/or genetic factors in the tongue. CONCLUSION: Since the 2G allele is a majority of the MMP-1 genotype in the general population, it seems to act as a genetic pre-condition in OSCC development. However this report suggests a crucial impact of the MMP-1 2G allele in the early onset OSCC.

DOI： 10.1186/1471-2407-7-187

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：BRITISH INST RADIOLOGY  

Objectives: Head and neck radiologists should be familiar with typical post-therapeutic changes on enhanced CT after neck dissection because CT is widely used for the follow-up study in order to detect recurrent turnours at an early stage. The purpose of this study was to reveal post-therapeutic anatomical alterations and non-neoplastic processes demonstrated on enhanced CT.
Methods: Radical neck dissections were performed in 39 necks and modified radical neck dissections were performed in 8 necks. Post-operative radiotherapy was performed on 21 patients. Follow-up CT, studies were made within a period of 24 months.
Results: On enhanced CT, the densities of soft tissues replacing the resected structures were homogeneous in 44 necks and showed no contrast enhancement in 39 necks. During the 24 months after treatment, most of the soft tissues did not increase in size and the attenuation of the soft tissue remained unchanged. In 44 of 47 necks, lymphoedema (LE) was observed around the carotid artery at an early stage, and it converged into the space between internal carotid artery and external carotid artery gradually. In patients without post-operative radiotherapy, LE was observed around the carotid artery in 17 of 23 necks at 3 months after neck dissection and disappeared rapidly thereafter. In patients with post-operative radiotherapy, LE increased until 3 months after radiotherapy and decreased slowly thereafter.
Conclusions: This is the first report of enhanced CT evaluation of LE around the carotid artery after neck dissection probably exacerbated by irradiation. Clinicians should be aware of LE around the carotid artery in patients with post-operative radiotherapy because of the possible risk of neck cellulitis at least 1 year after treatment.

File： dmfr_31581800.pdf

DOI： 10.1259/dmfr/31581800

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Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.5981/jjhnc.30.630

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Authorship：Lead author   Language：English   Publishing type：Research paper (international conference proceedings)  

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Language：English   Publishing type：Research paper (scientific journal)  

We present the non-contrast-enhanced CT finding of high attenuation within metastatic regional lymph nodes in two patients with stage I or II tongue carcinoma during a follow-up period. The attenuation values of these lesions were approximately 70 HU or more. One patient had a level I node, and the other had a level II node. Contrast-enhanced CT failed to reveal these hyperattenuated areas within the nodes. Histopathologic examination revealed that these hyperattenuated areas were strongly correlated with the area of marked keratinization of metastatic foci. If contrast-enhanced CT had been the only imaging technique used, these lesions might have been overlooked. The clinician should be aware of the characteristic findings of non-contrast-enhanced, as well as contrast-enhanced, CT when investigating lymph node metastases at an early stage in patients with stage I or II tongue carcinoma during the follow-up period.

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: We sought to assess the reliability of repeated sonography in the detection of cervical lymph node metastases at the earliest stage during a follow-up period in patients with stage I or stage II carcinoma of the tongue. STUDY DESIGN: Eighteen consecutive patients with stage I or II squamous cell carcinoma of the tongue were included. When possible, every patient was examined with sonography approximately every 2 weeks during the follow-up period. RESULTS: With repeated sonography on 18 patients, 7 metastatic nodes of 7 patients (39%) meeting our criteria were found. With the use of computed tomography, we diagnosed 10 nodes (including the 7 nodes observed with sonography) in these 7 patients as metastatic. A histopathologic examination revealed that 12 nodes in the same 7 patients had metastatic foci. For sonography, the sensitivity per node was 58%, whereas that of computed tomography was 83%. CONCLUSIONS: Follow-up sonography enabled the detection of all patients who had subsequent subclinical lymph node metastases. However, the sensitivity of sonography in the detection of smaller metastatic nodes was lower than that of computed tomography.

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DOI： 10.1038/sj.dmfr.4600679

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Soc. for Oral and Maxillofacial Radiology  

In order to assess the usefulness of repeated sonography in detecting cervical lymph node metastases at the earliest stage during a follow-up period in patients with stage I/II carcinoma, 20 consecutive patients with stage I/II squamous cell carcinoma of the tongue were studied. Each patient was examined repeatedly with sonography during the follow-up period. Nine metastatic nodes in 9 of the 20 patients (45%) met our criteria, and were detected by repeated sonography. Histopathological examination revealed that 14 nodes had metastatic foci. Although the sensitivity, per node, of sonography was originally only 64%, follow-up sonography detected all of the subclinical subsequent lymph node metastases among the patients in this study. In conclusion, repeated sonography was useful in the detection of lymph node metastases during follow-up care of patients with stage I/II tongue carcinoma, provided that the follow-up examination was performed at maximum interval of one month, if possible, sonography should be performed in such cases at two-week intervals for at least one and a half year.

DOI： 10.1007/BF02493266

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(NPO)日本歯科放射線学会  

1996〜2001年に治療したN0舌扁平上皮癌10例を対象とし,USにて検出した後発転移リンパ節を,CTデータによるvolume rendering法で作成した三次元表示画像で明示した.CT・USとも偽陰性のリンパ節は3個であった.USで転移が検出された10個のリンパ節は全てvolume rendering画像上で明示できた.又,周囲との解剖学的構造との位置関係を立体的に認識することが容易であった.オパシテイカーブについては,リンパ節の局在部位を検出するにはslope状のカーブが適し,リンパ節の辺縁を明確化するにはwedge状のカーブが適していた.wedge状のカーブでは,周囲の解剖構造の透過性を調整することにより,よりリンパ節の輪郭が明瞭になる傾向が認められた.一方リンパ節内部の中心壊死を明確に描出することは困難であった.転移リンパ節の診断精度を向上させることは無かった

DOI： 10.11242/dentalradiology1960.41.240

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2001&ichushi_jid=J00567&link_issn=&doc_id=20020130140003&doc_link_id=%2Fcg7dentr%2F2001%2F004104%2F003%2F0240-0244%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcg7dentr%2F2001%2F004104%2F003%2F0240-0244%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/BF02493266

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

81歳男.左側上顎第二小臼歯・第一大臼歯の齲蝕を歯科医院で抜去されたあと接触痛が持続し,歯肉に腫脹が出現した為自施設へ紹介された.初診時,同小臼歯・大臼歯の歯槽歯肉に25×15mmの腫瘍性潰瘍を認め,両側顎下・頸部に大豆大のリンパ節を触知した.歯肉病変は生検で扁平上皮癌と診断され,又,頸部転移を指摘された為上顎骨部分切除術+左側顎下・上内深頸リンパ節摘出術を行い,術後50Gy照射を追加した.手術から1年5ヵ月後,右上頸部に有痛性腫脹が出現し,手術制御不能と考え温熱療法+放射線療法+化学療法を行った.その7ヵ月後,胃生検で癌と診断され,転移性癌の可能性が高いと考えられたが原発巣は特定できず,初診から3年4ヵ月後呼吸不全の為死亡した.この患者は治療により口腔癌は制御できていたものの,高齢と口腔癌の既往の為に重複癌としての胃癌の内科的診断が遅れたことが反省させられる症例であった

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2001&ichushi_jid=J00999&link_issn=&doc_id=20010914360005&doc_link_id=http%3A%2F%2Fhdl.handle.net%2F10191%2F23179&url=http%3A%2F%2Fhdl.handle.net%2F10191%2F23179&type=%90V%8A%83%91%E5%8Aw%81F%90V%8A%83%91%E5%8Aw%8Aw%8Fp%83%8A%83%7C%83W%83g%83%8A_Nuar&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80230_3.gif

Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Oral and Maxillofacial Radiology  

<b>Purpose</b> To discuss the relationship between radiation bone injuries and a splitting of the cortical bone in the radiation field.<br><b>Patients and methods</b> Between January 1993 and September 1998, 53 patients with head and neck cancer received radiotherapy. The study cohort consisted of 23 patients who were followed with computed tomographic scans more than one year after radiotherapy. We evaluated clinical and computed tomographic features. Computed tomographic scanning was performed with a section thickness of 3 or 4mm. Bone images were obtained with identical window width (4000 Haunsfield units) and window level (1000 Haunsfield units). Splitting of the cortical bone was defined as disappearance of bone density in the cortical bone, showing a linear shape running parallel to the surface of the cortex.<br><b>Results</b> Splitting appeared in 9 sites in 8 patients. All patients fulfilled UICC criteria for classifying oral cancer. Most of the patients received external irradiation with a total radiation dose of 50 or 60Gy. In all cases, splitting was found in the mandibular cortex at the site of muscle attachment, that was included in the radiation field. Appearance of bone changes in chronological order were periosteal reaction, splitting and bone necrosis.<br><b>Conclusion</b> We speculate that splitting results from injuries to bone structure cells caused by blood flow disturbance after surgery and radiotherapy. It is suggested that such splitting can be a predictor of osteoradionecrosis.

File： 41_101.pdf

DOI： 10.11242/dentalradiology1960.41.101

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Language：English   Publishing type：Research paper (scientific journal)  

Objectives: To study whether primary tumor thickness of stage I/II tongue carcinoma provides information about subsequent lymph node metastasis. Methods: Twenty consecutive patients with T1N0M0 or T2N0M0 tongue carcinoma were studied. Primary tumor thickness was measured with post-contrast helical computed tomography or intra-oral sonography. Cervical lymph nodes were evaluated periodically with sonography at intervals of 2-4 weeks. Sensitivity, specificity and accuracy for subsequent metastasis was calculated. Results: Positive sonographic findings appeared in nine nodes of nine patients during this follow-up period. Eleven patients underwent neck dissections, and nine had histopathologically positive nodes. Nine patients had no sonographic findings of metastasis during a minimum follow-up period of 20 months. Primary tumor thickness varied from 3-16 mm. Using 5 mm as a cut-off thickness, the sensitivity, specificity and accuracy for subsequent lymph node metastasis were 64, 100 and 75% respectively. Conclusions: Patients with stage I/II tongue carcinoma which is more than 5 mm thick are more likely to develop lymph node metastasis.

DOI： 10.1038/sj.dmfr.4600615

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PubMed

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(NPO)日本歯科放射線学会  

specificity 70%以上を満たすという条件において,頸静脈二腹筋リンパ節の超音波による転移診断で一般に採用されている,短径8mmないし9mmの診断基準の妥当性が再確認された.加えて,患者が30歳代の場合には,50歳代以上の場合と比較して診断基準を1mm程度大きくすることが,specificityを維持する上で有意義と思われた

DOI： 10.11242/dentalradiology1960.40.33

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

Purpose: To evaluate the effect of oral hygiene care of patients with oral cancer on alleviating acute radiation mucositis. Materials and methods: Eighteen patients receiving postoperative radiotherapy for tongue and oral floor cancer were evaluated. Radiotherapy was given in 2 Gy per fraction, 5 times a week for a total dose of 50 Gy in most patients. Radiation fields included the tongue and oral floor. During radiotherapy, 8 patients were treated by dento-maxillofacial radiologists with special concern on oral hygiene (oral hygiene group) and the remaining 10 patients were treated with routine dental care (standard medication group). Mucositis were evaluated using JCOG grade and EORTC/RTOG score by radiotherapists or dento-maxillofacial radiologists at 10 Gy intervals. Oral hygiene plans comprised motivation to maintain oral hygiene and establishing the habits of oral self care 4 times per day. Once a week, oral hygiene and oral cleaning of patients were checked by dento-maxillofacial radiologists. Oral self care included mechanical tooth brushing and a chemical mouthwash. Results: No patients with grade 3 and score 4 mucositis were noted in the oral hygiene group. Severe mucositis occurred less frequently in the oral hygiene group than in the standard medication group. Interruption of radiotherapy due to severe mucositis did not occur in the oral hygiene group. On the other hand, interruption of radiotherapy occurred in four patients in the standard medication group, and in three it was due to severe oral pain. Conclusions: Our results suggested that our method of oral hygiene was more effective for alleviating acute radiation mucositis than other methods so far reported. In addition, our method is considered to be useful in preventing rampant dental caries and severe periodontitis due to the xerostomia induced by radiotherapy. © 2000, Japanese Society for Therapeutic Radiology and Oncology. All rights reserved.

File： 12_229 (14).pdf

DOI： 10.11182/jastro1989.12.229

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

File： NS_29(1)_17-22.pdf

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Total pages：508   Responsible for pages：51-59   Language：Japanese Book type：Scholarly book

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Total pages：344   Responsible for pages：89-98   Language：Japanese Book type：Scholarly book

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Total pages：344   Responsible for pages：35-42   Language：Japanese Book type：Scholarly book

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Total pages：344   Responsible for pages：117-122   Language：Japanese Book type：Scholarly book

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Total pages：vii, 166p   Responsible for pages：138-150   Language：Japanese Book type：General book, introductory book for general audience

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Total pages：213   Responsible for pages：336-342   Language：Japanese Book type：General book, introductory book for general audience

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Total pages：258   Language：Japanese Book type：Scholarly book

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ASIN

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Language：Japanese Book type：Scholarly book

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Language：English Book type：Scholarly book

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Authorship：Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

File： image7.pdf

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Other Link： https://jaoscc.org/publication.html

Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Language：Japanese   Publisher：(株)照林社  

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Language：Japanese   Publisher：新潟医学会  

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J-GLOBAL

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(公社)日本歯科医師会  

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J-GLOBAL

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(株)照林社  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：アステラス製薬(株)  

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J-GLOBAL

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Language：Japanese   Publisher：医歯薬出版(株)  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(一社)日本口腔衛生学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher：南江堂  

DOI： 10.15106/J03022.2016236101

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(一社)日本口腔ケア学会  

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Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher：(株)第一歯科出版  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(一社)日本口腔ケア学会  

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J-GLOBAL

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(株)デンタルダイヤモンド社  

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Authorship：Lead author,　Corresponding author   Language：Japanese  

J-GLOBAL

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Language：Japanese   Publisher：新潟歯学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(一社)日本口腔ケア学会  

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Language：Japanese   Publisher：新潟歯学会  

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Language：Japanese   Publisher：新潟歯学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：新潟医学会  

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Authorship：Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：・・・・  

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Language：Japanese   Publisher：(一社)日本口腔腫瘍学会  

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Language：Japanese  

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Other Link： http://search.jamas.or.jp/link/ui/2008156700

Language：Japanese   Publisher：新潟大学  

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Other Link： http://search.jamas.or.jp/link/ui/2007122221

Language：Japanese   Publisher：新潟歯学会  

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Language：Japanese   Publisher：Niigata University  

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Other Link： http://search.jamas.or.jp/link/ui/2004149954

Language：Japanese   Publisher：新潟大学  

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Other Link： http://search.jamas.or.jp/link/ui/2003102882

Authorship：Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

File： t312_katsura.pdf

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Other Link： http://search.jamas.or.jp/link/ui/2002209827

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Language：Japanese  

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Language：Japanese  

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Language：Japanese   Publisher：新潟大学  

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Other Link： http://search.jamas.or.jp/link/ui/2000151860

Language：Japanese   Publisher：新潟大学  

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Other Link： http://search.jamas.or.jp/link/ui/2000148523

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Language：Japanese  

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Language：Japanese   Publisher：新潟医学会  

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Other Link： http://search.jamas.or.jp/link/ui/2000017729

Language：Japanese   Publisher：新潟医学会  

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Other Link： http://search.jamas.or.jp/link/ui/1998193348

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CiNii Article

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Event date： 2022.2

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Event date： 2021.5

Presentation type：Oral presentation (invited, special)  

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Event date： 2021.5

Presentation type：Symposium, workshop panel (nominated)  

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Language：Japanese  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：ランドマークホール 横浜  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：金沢市  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：横須賀市  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：札幌  

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Venue：博多  

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Venue：愛知県がんセンター中央病院 国際交流センター メインホール  

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Venue：アートホテル新潟駅前  

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Venue：品川フロントビル  

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Venue：ホテルオークラ新潟 新潟市  

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Venue：佐渡総合病院 講堂  

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Venue：アートホテル新潟駅前 新潟市  

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Venue：電気ビル共創館 福岡市  

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Venue：沼津  

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Venue：福岡市  

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Venue：静岡がんセンター  

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Venue：済生会新潟第二病院  

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Venue：重粒子医科学センター病院  

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Venue：新潟大学医歯学総合病院  

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Venue：国立がん研究センター  

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Venue：下関市  

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Venue：仙台市  

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Venue：新潟  

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Venue：福岡市  

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Venue：渋川市  

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Venue：新潟市  

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Venue：上越市  

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Venue：旭川市  

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Venue：新潟市  

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Venue：新潟市  

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Venue：岡山市  

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Venue：新潟市  

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Venue：上越市  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：東京.  

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Award type：Honored in official journal of a scientific society, scientific journal  Country：Japan

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