Language：English   Publishing type：Research paper (international conference proceedings)  

DOI： 10.1007/s00520-024-08541-z

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：XMLink  

File： 2080ISD_isd-54-e14.pdf

DOI： 10.5624/isd.20230230

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Language：Japanese   Publisher：(株)照林社  

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Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

(1) Background: In oral cancer staging, ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) with positron emission tomography/computed tomography (PET/CT) are routinely used in clinical practice. The present study is a retrospective examination of the diagnostic accuracy of cervical lymph node metastasis using US, CT, MRI, and PET/CT, with histopathological diagnosis as a reference, to compare the different diagnostic imaging modalities. (2) Methods: The participants included 16 patients with oral squamous cell carcinoma who underwent US-, CT-, MRI-, and PET/CT-based preoperative diagnostic imaging and simultaneous primary lesion resection and neck dissection, including 82 level regions and 424 lymph nodes. We compared the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of each imaging modality based on the imaging results and the pathology results of metastasis. (3) Results: Of the four diagnostic imaging modalities, PET/CT exhibited the highest sensitivity but the lowest specificity and accuracy. US, CT, and MRI had high specificities. Comparing each level region and lymph node showed that differences were observed in PET/CT. (4) Conclusions: PET/CT to diagnose lymph node metastasis requires a comprehensive evaluation because it produces more false positives than other diagnostic imaging modalities. Using US, CT, and MRI, which have excellent spatial resolution, improves diagnostic accuracy at the lymph node level.

DOI： 10.3390/biomedicines11123119

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (international conference proceedings)  

DOI： 10.1007/s00520-023-07786-4

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Language：English   Publishing type：Research paper (scientific journal)  

PURPOSE: Oral mucositis is a severe adverse event in patients with head and neck cancer (HNC) receiving chemotherapy and radiotherapy that may cause the termination of cancer treatment. In this study, we aimed to reveal the benefits of pharmacist interventions in oral health care for patients with HNC receiving concurrent chemoradiotherapy (CCRT). METHODS: We conducted a multicenter, prospective cohort study on 173 patients from September 2019 to August 2022. We evaluated the association between the occurrence of oral mucositis during CCRT and various factors in the absence or presence of direct medication instructions from hospital pharmacists. RESULTS: Sixty-eight patients received medication instructions from pharmacists (the pharmacist intervention group), whereas 105 patients did not receive instructions (the control group). Logistic regression analysis showed that grade 2 (Gr 2) oral mucositis was significantly lower in patients receiving pharmacist interventions than in patients in the control group (adjusted odds ratio [aOR], 0.42; 95% confidence interval [CI], 0.18-0.96; P = 0.04). The time to onset of Gr 2 oral mucositis was significantly longer in the pharmacist intervention group than in the control group (hazard ratio, 0.53; 95% CI, 0.29-0.97; P = 0.04). CONCLUSION: Direct intervention, especially when provided by hospital pharmacists, can have a real effect in supporting patients with HNC experiencing severe side effects of treatments. Moreover, the integration of pharmacists into the oral healthcare team is becoming even more essential to reduce the severity of side effects.

DOI： 10.1007/s00520-023-07784-6

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Language：Japanese   Publisher：新潟医学会  

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

(1) Background: The impacts of metal artifacts (MAs) on the contouring workload for head and neck radiotherapy have not yet been clarified. Therefore, this study evaluated the relationship between the contouring time of the MAs area and MAs on head and neck radiotherapy treatment planning. (2) Methods: We used treatment planning computed tomography (CT) images for head and neck radiotherapy. MAs were classified into three severities by the percentage of CT images containing MAs: mild (<25%), moderate (25–75%), and severe (>75%). We randomly selected nine patients to evaluate the relationship between MAs and the contouring time of the MAs area. (3) Results: The contouring time of MAs showed moderate positive correlations with the MAs volume and the number of CT images containing MAs. Interobserver reliability of the extracted MAs volume and contouring time were excellent and poor, respectively. (4) Conclusions: Our study suggests that the contouring time of MAs areas is related to individual commitment rather than clinical experience. Therefore, the development of software combining metal artifact reduction methods with automatic contouring methods is necessary to reducing interobserver variability and contouring workload.

File： tomography-09-00009 (1).pdf

DOI： 10.3390/tomography9010009

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OBJECTIVE: Side-effects of medications cause xerostomia. There have been cases where a medication has been discontinued owing to its severe side-effects. Therefore, the xerostomia must be treated to ensure that the primary disease is managed effectively. This study analyzed the actual status of patients with medication-induced xerostomia and investigates factors associated with its improvement. METHODS: This study assessed 490 patients diagnosed with medication-induced xerostomia who had an unstimulated salivary flow of ≤0.1 mL/min and received treatment for xerostomia at a xerostomia clinic. Patient age, sex, medical history, medications used, disease duration of xerostomia, and psychological disorders were recorded. The anticholinergic burden was assessed using the Anticholinergic Cognitive Burden scale. The unstimulated salivary flow was measured by the spitting method. According to their symptoms and diagnoses, the patients were introduced to oral lubricants, instructed on how to perform massage, and prescribed Japanese herbal medicines, and sialogogues. Factors associated with the subjective improvement of xerostomia and objective changes in the salivary flow rate were recorded at six months. RESULTS: Xerostomia improved in 338 patients (75.3%). The improvement rate was significantly lower in patients with psychiatric disorders (63.6%) (P = 0.009). The improvement rate decreased as more anticholinergics were used (P = 0.018). However, xerostomia improved in approximately 60% of patients receiving three or more anticholinergics. The unstimulated salivary flow increased significantly more in patients who reported an improvement of xerostomia (0.033±0.053 mL/min) than in those who reported no improvement (0.013±0.02 mL/min) (P = 0.025). CONCLUSION: Xerostomia treatment improved oral dryness in 75.3% of patients receiving xerogenic medications in this study. If xerostomia due to side-effects of medications can be improved by treatment, it will greatly contribute to the quality of life of patients with xerogenic medications and may reduce the number of patients who discontinue medications.

DOI： 10.1371/journal.pone.0280224

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Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.11242/dentalradiology.61.41

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Oral and Maxillofacial Radiology  

DOI： 10.11242/dentalradiology.61.53

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/osi2.1129

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/osi2.1129

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: This study aimed to clarify the accuracy of intraoral ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) in preoperative image depth of invasion (DOI) measurement of T1/T2 tongue cancer through comparison with histopathological measurements. METHODS: Imaging of the primary lesions was performed at our hospital; the lesions were classified into T1 and T2 based on the 8th edition of the AJCC/UICC, and surgery performed. There was histopathological confirmation of lesions as squamous cell carcinoma in 48 patients with tongue cancer. T3 and T4 cases, cases in which preoperative chemotherapy and radiation therapy were performed, and cases where biopsy was performed before imaging were excluded. The radiological DOI in US, CT, and MRI and the histopathological DOI as base were comparatively investigated and statistical analyses were performed by Bland-Altman analysis and Spearman's rank correlation coefficient. RESULTS: Bland-Altman analysis showed that the US radiological DOI was overestimated by an average of 0.2 mm compared to the histopathological DOI, while CT and MRI radiological DOI were overestimated by an average of 2-3 mm. The comparison of CT and MRI revealed that the difference between the MRI and histopathological DOI, as well as the 95% limit of agreement, were smaller than those of the CT radiological DOI. CONCLUSIONS: US is the most accurate preoperative diagnostic tool for T1 and T2 squamous cell carcinoma; CT and MRI tend to have an overestimation of about 2-3 mm and so caution is required.

DOI： 10.1007/s11282-021-00533-7

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

PURPOSE: Bloodstream infection (BSI) is a major complication of allogeneic hematopoietic stem-cell transplantation (allo-SCT). There are several causes of BSI; in particular, severe oral mucositis (OM) can induce BSI due to coagulase-negative staphylococci (CoNS). The OM severity may be reduced with intensive oral care. Thus, we evaluated whether the type of oral care affects the BSI incidence eventually. METHOD: We performed retrospective analysis on 206 recipients who underwent allo-SCT from 2006 to 2017 at our institute. Intensive oral care by a dental specialist was performed for 111 recipients (intensive-care group) and self-oral care was performed by 95 recipients (self-care group). Incidence of BSI was assessed by type of the oral care, before neutrophil engraftment (pre-E-BSI) and after neutrophil engraftment (post-E-BSI) period until 180 days after allo-SCT. RESULT: A total of 112 BSI occurred in 90 of the 206 recipients and 120 bacteria were identified, with CoNS being the most prevalent. There was no significant difference in the incidence of pre-E-BSI between the self-care and intensive-care groups (30.8% and 30.6%, respectively; P = 0.508). Meanwhile, the incidence of post-E-BSI was significantly lower in the intensive-care group than in the self-care group (14.3% and 28.6%; P = 0.008). In addition, the intensive-care group had significantly lower incidence of post-E-BSI with CoNS than the self-care group (8.5% and 21.5%, respectively; P = 0.009). CONCLUSION: Intensive oral care through the period of allo-HCT can significantly reduce the post-E-BSI occurrence, especially due to CoNS.

DOI： 10.1007/s00520-021-06447-8

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Other Link： https://link.springer.com/article/10.1007/s00520-021-06447-8/fulltext.html

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Public Library of Science (PLoS)  

<sec id="sec001">
<title>Objectives</title>
This retrospective study examined how a pharmacist-involved education program in a multidisciplinary team (PEMT) for oral mucositis (OM) affected head-and-neck cancer (HNC) patients receiving concurrent chemoradiotherapy (CCRT).


</sec>
<sec id="sec002">
<title>Materials and methods</title>
Total samples data of 53 patients during the stipulated timeframe were retrospectively collected from electronic medical records from February 2017 to January 2019. We compared the presence/absence of OM (OM: yes/no) between patients with and without PEMT (PEMT: yes/no) as the primary endpoint and OM severity as the secondary endpoint. The following information was surveyed: age, gender, weight loss, steroid or immunosuppressant use, hematological values (albumin, white blood cell count, blood platelets, and neutrophils), cancer grade, primary cancer site, type and use of mouthwash and moisturizer, opioid use (yes/no, days until the start of opioid use, and dose, switch to tape), and length of hospital day (LOD). The two groups were compared using Fisher’s exact test for qualitative data and the Mann-Whitney U test for quantitative data, and a significance level of <italic>p&lt;0</italic>.<italic>05</italic> was set.


</sec>
<sec id="sec003">
<title>Results</title>
The group managed by PEMT had significantly lower weight loss and a significantly lower incidence of local anesthetic and opioid use and switch to tape compared with the group not managed by PEMT (<italic>p&lt;0</italic>.<italic>05</italic>). The two groups showed no significant difference in OM (yes/no) or OM severity. The PEMT group had significantly shorter LOD at 57 (53–64) days compared with the non-PEMT group at 63.5 (57–68) days (<italic>p&lt;0</italic>.<italic>05</italic>).


</sec>
<sec id="sec004">
<title>Conclusions</title>
Our results showed that PEMT did not improve OM (yes/no) or OM severity in HNC patients undergoing CCRT. However, the PEMT group had a lower incidence of grades 3 and 4 OM than the non-PEMT group, although not significantly. In addition, PEMT contributed to oral pain relief and the lowering of the risk for OM by reduction in weight loss.


</sec>

File： journal.pone.0260026.pdf

DOI： 10.1371/journal.pone.0260026

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The clinical features of xerostomia induced by immune checkpoint inhibitors (ICI) are similar to those of Sjögren's syndrome (SS), whereas the immunohistological and serological features are known to differ from those of SS. However, the radiologic imaging features of salivary glands are not yet well known. We report a case of a 56-year-old male patient diagnosed with ICI-induced xerostomia. The patient underwent various imaging examinations to investigate the condition of the salivary glands, which indicated the following: (1) less specific findings on contrast-enhanced computed tomography, (2) mixed with intermediate and low signal intensity on both T1-weighted and fat-suppressed T2-weighted magnetic resonance imaging and poor "salt and pepper" appearance on magnetic resonance sialography, and (3) multiple ovoid hypoechoic areas with hyperechoic bands without acute sialadenitis on ultrasound. These radiologic imaging findings suggested remarkable lymphocyte infiltration, which could be a characteristic of ICI-induced xerostomia.

File： s11282-020-00480-9 (3).pdf

DOI： 10.1007/s11282-020-00480-9

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

R2TP is a well-conserved molecular chaperone complex, composed of Pontin, Reptin, RPAP3, and PIH1D, in eukaryotes. Recent studies have suggested an involvement of R2TP in cancer development. However, it remains unclear if it is related to the development of oral squamous cell carcinoma (OSCC), which is the most common type of oral cancer. Here, we identify and investigate the function of R2TP in OSCC development. Immunohistochemical analysis reveals that all of the R2TP components are strongly expressed in normal oral epithelia and OSCC tissues, where actively proliferating cells are abundant. Co-immunoprecipitation assay identifies that R2TP components form a protein complex in OSCC-derived HSC4-cells. Knockdown experiments show that all R2TP components, except for RPAP3, are required for the cell proliferation and migration of HSC-4 cells. Furthermore, we reveal that Pontin contributes to a gain-of-function (GOF) activity of mutp53-R248Q in HSC-4 cells by regulating phosphorylation levels of mutp53 at Ser15 and Ser46. To our knowledge, this study is the first to report the functional involvement of R2TP and its components in the malignant characteristics of OSCC cells.

DOI： 10.1016/j.bbrc.2021.02.074

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/osi2.1110

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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ABSTRACT: The purpose of the present study was to investigate the efficacy of perioperative oral managements (POMs) on perioperative nutritional conditions in patients undergoing surgery with general anesthesia. Medical records were retrospectively reviewed and the effects of POMs were investigated based on a large number of cases using a multicenter analysis. The profile of serum albumin levels was assessed and compared between patients with and without POMs using the multivariate analysis. Seventeen Eleven thousand and one hundred sixty patients (4,873 males and 6,287 females) were reviewed. Of these, 2710 patients (24.3%) had undergone POMs. The results of a multivariate analysis revealed the significant positive effect of POMs on perioperative serum albumin level (change between at admission and discharge, (Estimate: 0.022, standard error: 0.012, P < .0001). Patient gender, age, surgical site, performance status, the American Society of Anesthesiologists (ASA) physical status classification, operation time, amount of blood loss, and serum albumin level at admission were also significant predictors. Adjusted multivariate analysis of the effects of POMs on perioperative change of serum albumin level in all subjects reveled the significance of POMs intervention (estimate: 0.022, standard error: 0.012, P < .0001). These results suggest that POMs exerts significant positive effects on perioperative serum albumin levels in patients underwent surgery under general anesthesia.

File： the_effects_of_perioperative_oral_management_on.103 (1).pdf

DOI： 10.1097/MD.0000000000025119

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

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File： 1-s2.0-S2405630819301065-main.pdf

DOI： 10.1016/j.ctro.2019.10.006

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File： 1-s2.0-S0385814617309331-main.pdf

DOI： 10.1016/j.anl.2018.02.008

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(一社)日本摂食嚥下リハビリテーション学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J03152&link_issn=&doc_id=20190416130007&doc_link_id=%2Fcb5dvsph%2F2018%2F002202%2F007%2F0153-0160%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcb5dvsph%2F2018%2F002202%2F007%2F0153-0160%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：English   Publishing type：Research paper (scientific journal)  

File： s11282-016-0269-1.pdf

DOI： 10.1007/s11282-016-0269-1

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DOI： 10.1111/jog.13290

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(一社)日本口腔ケア学会  

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File： s11282-015-0218-4.pdf

DOI： 10.1007/s11282-015-0218-4

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1155/2016/4898456

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publisher：(一社)日本口腔ケア学会  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Society of Oral Diagnosis / Oral Medicine  

We investigated the relationship between oral care and candida species in 16 patients (14 men and 2 women) undergoing radiotherapy for head and neck cancer. They also received oral care by specialized dental staff. Candida species were detected in 12 patients (75% of all patients): <i>C. albicance</i> was detected in 8 cases (50%) and non-<i>C. albicance</i> was detected in 4 cases (25%). Advanced oral mucositis of more than grade 3 was seen in 13 patients, and candida species were detected in 11 cases.<br>Oral care in consideration of candida species is important because <i>C. albicance</i> and non-<i>C. albicance</i> were frequently detected in patients undergoing radiotherapy for head and neck cancer even though their oral condition was well maintained.

File： 27_1.pdf

DOI： 10.15214/jsodom.27.1

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Other Link： http://search.jamas.or.jp/link/ui/2014220823

Language：Japanese   Publisher：(一社)日本口腔衛生学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J00440&link_issn=&doc_id=20130808300003&doc_link_id=%2Fdk1dehea%2F2013%2F006304%2F003%2F0337-0343%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2013%2F006304%2F003%2F0337-0343%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

File： s11282-012-0102-4.pdf

DOI： 10.1007/s11282-012-0102-4

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Language：English   Publisher：Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo  

<b>Aim</b>: In dental treatment, to remove an instrument, such as dental mirror or to remove a dental cotton roll inserted in the gingivobuccal fold, often brings the patient discomfort or pain. To prevent these uncomfortable conditions, dental instruments or dental cotton rolls are moistened based on an empirical basis. However, there has been no research done evaluating whether discomfort is reduced by these techniques. The purpose of this study was to evaluate the effects of moistened techniques on the patientsʼ discomfort and the operatorsʼ ease. <b>Materials and Methods</b>: Thirty eight subjects without hyposalivation were studied. Two procedures were implemented. One was that a dry or moistened dental mirror was removed after exclusion of the buccal mucosa. The other was removal of a dental cotton roll from the gingivobuccal fold after either moistening it or leaving it dry. The subjectsʼcomfort and the operatorsʼ treatment ease were evaluated on five point scales. <b>Results</b>: During these procedures, the subjectsʼ comfort was significantly increased by moistening of both the dental mirror and the cotton roll. The ease of performing both procedures was also significantly increased for operators in the moistened condition. In addition, there was a significant positive correlation between the subjectsʼ comfort and the operatorsʼ ease. <b>Conclusion</b>: When using dental instruments and removing cotton rolls, moistening increases both the subjectsʼ comfort and operatorsʼ treatment ease.

DOI： 10.5466/ijoms.11.85

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Other Link： http://search.jamas.or.jp/link/ui/2014000129

Language：English   Publisher：Japanese Association for Oral Biology  

DOI： 10.2330/joralbiosci.53.31

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File： dmfr_55423624.pdf

DOI： 10.1259/dmfr/55423624

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

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DOI： 10.1016/j.cca.2009.03.018

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File： 35_266.pdf

DOI： 10.5981/jjhnc.35.266

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File： 1-s2.0-S1079210407008311-main.pdf

DOI： 10.1016/j.tripleo.2007.10.011

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1186/1471-2407-7-187

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

File： dmfr_31581800.pdf

DOI： 10.1259/dmfr/31581800

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Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.5981/jjhnc.30.630

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Authorship：Lead author   Language：English   Publishing type：Research paper (international conference proceedings)  

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We present the non-contrast-enhanced CT finding of high attenuation within metastatic regional lymph nodes in two patients with stage I or II tongue carcinoma during a follow-up period. The attenuation values of these lesions were approximately 70 HU or more. One patient had a level I node, and the other had a level II node. Contrast-enhanced CT failed to reveal these hyperattenuated areas within the nodes. Histopathologic examination revealed that these hyperattenuated areas were strongly correlated with the area of marked keratinization of metastatic foci. If contrast-enhanced CT had been the only imaging technique used, these lesions might have been overlooked. The clinician should be aware of the characteristic findings of non-contrast-enhanced, as well as contrast-enhanced, CT when investigating lymph node metastases at an early stage in patients with stage I or II tongue carcinoma during the follow-up period.

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OBJECTIVE: We sought to assess the reliability of repeated sonography in the detection of cervical lymph node metastases at the earliest stage during a follow-up period in patients with stage I or stage II carcinoma of the tongue. STUDY DESIGN: Eighteen consecutive patients with stage I or II squamous cell carcinoma of the tongue were included. When possible, every patient was examined with sonography approximately every 2 weeks during the follow-up period. RESULTS: With repeated sonography on 18 patients, 7 metastatic nodes of 7 patients (39%) meeting our criteria were found. With the use of computed tomography, we diagnosed 10 nodes (including the 7 nodes observed with sonography) in these 7 patients as metastatic. A histopathologic examination revealed that 12 nodes in the same 7 patients had metastatic foci. For sonography, the sensitivity per node was 58%, whereas that of computed tomography was 83%. CONCLUSIONS: Follow-up sonography enabled the detection of all patients who had subsequent subclinical lymph node metastases. However, the sensitivity of sonography in the detection of smaller metastatic nodes was lower than that of computed tomography.

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1038/sj.dmfr.4600679

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Soc. for Oral and Maxillofacial Radiology  

DOI： 10.1007/BF02493266

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(NPO)日本歯科放射線学会  

DOI： 10.11242/dentalradiology1960.41.240

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2001&ichushi_jid=J00567&link_issn=&doc_id=20020130140003&doc_link_id=%2Fcg7dentr%2F2001%2F004104%2F003%2F0240-0244%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcg7dentr%2F2001%2F004104%2F003%2F0240-0244%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

File： t312_katsura.pdf

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/BF02493266

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2001&ichushi_jid=J00999&link_issn=&doc_id=20010914360005&doc_link_id=http%3A%2F%2Fhdl.handle.net%2F10191%2F23179&url=http%3A%2F%2Fhdl.handle.net%2F10191%2F23179&type=%90V%8A%83%91%E5%8Aw%81F%90V%8A%83%91%E5%8Aw%8Aw%8Fp%83%8A%83%7C%83W%83g%83%8A_Nuar&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80230_3.gif

Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Oral and Maxillofacial Radiology  

<b>Purpose</b> To discuss the relationship between radiation bone injuries and a splitting of the cortical bone in the radiation field.<br><b>Patients and methods</b> Between January 1993 and September 1998, 53 patients with head and neck cancer received radiotherapy. The study cohort consisted of 23 patients who were followed with computed tomographic scans more than one year after radiotherapy. We evaluated clinical and computed tomographic features. Computed tomographic scanning was performed with a section thickness of 3 or 4mm. Bone images were obtained with identical window width (4000 Haunsfield units) and window level (1000 Haunsfield units). Splitting of the cortical bone was defined as disappearance of bone density in the cortical bone, showing a linear shape running parallel to the surface of the cortex.<br><b>Results</b> Splitting appeared in 9 sites in 8 patients. All patients fulfilled UICC criteria for classifying oral cancer. Most of the patients received external irradiation with a total radiation dose of 50 or 60Gy. In all cases, splitting was found in the mandibular cortex at the site of muscle attachment, that was included in the radiation field. Appearance of bone changes in chronological order were periosteal reaction, splitting and bone necrosis.<br><b>Conclusion</b> We speculate that splitting results from injuries to bone structure cells caused by blood flow disturbance after surgery and radiotherapy. It is suggested that such splitting can be a predictor of osteoradionecrosis.

File： 41_101.pdf

DOI： 10.11242/dentalradiology1960.41.101

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1038/sj.dmfr.4600615

Scopus

PubMed

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(NPO)日本歯科放射線学会  

DOI： 10.11242/dentalradiology1960.40.33

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2000&ichushi_jid=J00567&link_issn=&doc_id=20000530030004&doc_link_id=%2Fcg7dentr%2F2000%2F004001%2F004%2F0033-0037%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcg7dentr%2F2000%2F004001%2F004%2F0033-0037%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

File： 12_229 (14).pdf

DOI： 10.11182/jastro1989.12.229

Scopus

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：新潟歯学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

File： NS_29(1)_17-22.pdf

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Total pages：508   Responsible for pages：51-59   Language：Japanese Book type：Scholarly book

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Total pages：344   Responsible for pages：89-98   Language：Japanese Book type：Scholarly book

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Total pages：344   Responsible for pages：35-42   Language：Japanese Book type：Scholarly book

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Total pages：344   Responsible for pages：117-122   Language：Japanese Book type：Scholarly book

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Total pages：vii, 166p   Responsible for pages：138-150   Language：Japanese Book type：General book, introductory book for general audience

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Total pages：213   Responsible for pages：336-342   Language：Japanese Book type：General book, introductory book for general audience

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Total pages：258   Language：Japanese Book type：Scholarly book

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ASIN

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Language：Japanese Book type：Scholarly book

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Language：English Book type：Scholarly book

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

File： image7.pdf

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Other Link： https://jaoscc.org/publication.html

Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Language：Japanese   Publisher：(株)照林社  

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Language：Japanese   Publisher：新潟医学会  

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J-GLOBAL

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J-GLOBAL

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(株)照林社  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：アステラス製薬(株)  

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J-GLOBAL

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Language：Japanese   Publisher：医歯薬出版(株)  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(一社)日本口腔衛生学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher：南江堂  

DOI： 10.15106/J03022.2016236101

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(一社)日本口腔ケア学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(一社)日本口腔ケア学会  

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J-GLOBAL

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(株)デンタルダイヤモンド社  

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Authorship：Lead author,　Corresponding author   Language：Japanese  

J-GLOBAL

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Language：Japanese   Publisher：新潟歯学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(一社)日本口腔ケア学会  

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Language：Japanese   Publisher：新潟歯学会  

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Language：Japanese   Publisher：新潟歯学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：新潟医学会  

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Authorship：Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：・・・・  

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Language：Japanese   Publisher：(一社)日本口腔腫瘍学会  

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Language：Japanese  

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Other Link： http://search.jamas.or.jp/link/ui/2008156700

Language：Japanese   Publisher：新潟大学  

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Other Link： http://search.jamas.or.jp/link/ui/2007122221

Language：Japanese   Publisher：新潟歯学会  

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Language：Japanese   Publisher：Niigata University  

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Other Link： http://search.jamas.or.jp/link/ui/2004149954

Language：Japanese   Publisher：新潟大学  

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Other Link： http://search.jamas.or.jp/link/ui/2003102882

Authorship：Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

File： t312_katsura.pdf

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Other Link： http://search.jamas.or.jp/link/ui/2002209827

Language：Japanese  

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CiNii Books

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Language：Japanese  

CiNii Article

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Language：Japanese  

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Language：Japanese  

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Language：Japanese   Publisher：新潟大学  

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Other Link： http://search.jamas.or.jp/link/ui/2000151860

Language：Japanese   Publisher：新潟大学  

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Other Link： http://search.jamas.or.jp/link/ui/2000148523

Language：Japanese  

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Language：Japanese  

CiNii Article

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Language：Japanese  

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Language：Japanese   Publisher：新潟医学会  

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Other Link： http://search.jamas.or.jp/link/ui/2000017729

Language：Japanese   Publisher：新潟医学会  

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Other Link： http://search.jamas.or.jp/link/ui/1998193348

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CiNii Article

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Event date： 2024.1

Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Event date： 2023.11

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2022.2

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Event date： 2021.5

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Event date： 2021.5

Presentation type：Symposium, workshop panel (nominated)  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：ランドマークホール 横浜  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：金沢市  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：横須賀市  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：札幌  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：博多  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：愛知県がんセンター中央病院 国際交流センター メインホール  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：アートホテル新潟駅前  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：品川フロントビル  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：ホテルオークラ新潟 新潟市  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：佐渡総合病院 講堂  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：アートホテル新潟駅前 新潟市  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：電気ビル共創館 福岡市  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：沼津  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：福岡市  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：静岡がんセンター  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：済生会新潟第二病院  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：重粒子医科学センター病院  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：新潟大学医歯学総合病院  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：国立がん研究センター  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：下関市  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：仙台市  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：新潟  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：福岡市  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：新潟市  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：福岡市  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：渋川市  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：新潟市  

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Language：English   Presentation type：Oral presentation (invited, special)  

Venue：上越市  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：旭川市  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：新潟市  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：新潟市  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：岡山市  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：札幌市  

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Language：English   Presentation type：Oral presentation (invited, special)  

Venue：上越市  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：新潟市  

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Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：上越市  

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Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：東京.  

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Award type：Honored in official journal of a scientific society, scientific journal  Country：Japan

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File： chemotherapyforpatients.pdf

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