研究者詳細 - 小原　健司

論文 - 小原　健司

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Free tube graft法による尿道下裂修復術の成績

小原健司, 筒井寿基, 水澤隆樹, 星井達彦, 小松集一, 丸山亮, 新井啓, 原昇, 笠原隆, 石崎文雄, 高橋公太

日本泌尿器科学会雑誌 103 ( 2 ) 520 - 520 2012年3月

A case of true ureteral diverticulum on functional solitary kidney 査読

Tsutomu Anraku, Takaki Mizusawa, Kenji Obara, Hiromi Sato, Yoichi Ajioka, Kota Takahashi

Japanese Journal of Urology 103 ( 3 ) 569 - 572 2012年

The case of retroperitoneoscopic nephrectomy for hypoplastic kidney with ectopic ureter

Yuko Shirono, Takashi Kasahara, Kei Arai, Kenji Obara, Tsutomu Nishiyama, Kota Takahashi

Japanese Journal of Clinical Urology 65 ( 5 ) 323 - 326 2011年4月

Clinical feature of men who benefit from dose escalation of naftopidil for lower urinary tract symptoms: A prospective study 査読

Noboru Hara, Takaki Mizusawa, Kenji Obara, Etsuko Isahaya, Yuki Nakagawa, Kota Takahashi

Advances in Urology 2011年

Efficacy of clean intermittent catheterization（CIC）for urinary incontinence in children with neurogenic bladder dysfunction secondary to myelodysplasia 査読

小原健司

LUTS 2 ( 2 ) 100 - 105 2010年9月

小児の過活動膀胱患者に対するコハク酸ソリフェナシンの使用経験査読

小原健司

小児科臨床 63 ( 9 ) 20272032 2010年

Primitive neuroectodermal tumor of the adrenal gland 査読

Shuichi Komatsu, Ryusuke Watanabe, Masaaki Naito, Takaki Mizusawa, Kenji Obara, Tsutomu Nishiyama, Kota Takahashi

International Journal of Urology 13 ( 5 ) 606 - 607 2006年5月

Role of connective tissue growth factor in fibronectin synthesis in cultured human prostate stromal cells. 国際誌

Kazuya Suzuki, Kenji Obara, Kazuhiro Kobayashi, Kazutoshi Yamana, Vladimir Bilim, Toshiyuki Itoi, Kota Takahashi

Urology 67 ( 3 ) 647 - 53 2006年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: To clarify the correlation of connective tissue growth factor (CTGF) expression and fibronectin (FN) synthesis after transforming growth factor-beta-1 (TGF-beta1) stimulation in human prostate stromal cells. METHODS: Primary cultures of human prostate stromal cells were established from nine normal prostates by the explant method. The gene and protein expressions of CTGF and FN after TGF-beta1 treatment were examined. We also investigated the effect of CTGF blockade on TGF-beta1-induced FN synthesis by CTGF antisense oligodeoxynucleotide treatment. RESULTS: CTGF expression was detected in all nine prostate stromal cells by reverse transcriptase-polymerase chain reaction and immunoblotting. In prostatic tissues, CTGF expression was observed more strongly in epithelial cells than in the stromal area by immunohistochemistry. The upregulation of both CTGF and FN protein by TGF-beta1 treatment was demonstrated in a dose-dependent manner. CTGF antisense oligodeoxynucleotide inhibited TGF-beta1-stimulated FN synthesis. CONCLUSIONS: CTGF plays a crucial role in extracellular matrix production as a TGF-beta1 downstream mediator in human prostate stromal cells, suggesting that CTGF blockade is likely to be a therapeutic target against benign prostatic hyperplasia.

PubMed

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Obstruction of the ileal ureter by mesenteric vessels occurring 5 years after total ureteral substitution for bilateral ureteral stenosis due to systemic lupus erythematosus 査読

Kazuhiro Kobayashi, Kenji Obara, Ryusuke Watanabe, Noboru Hara, Akiyoshi Katagiri, Kota Takahashi

International Journal of Urology 13 ( 1 ) 80 - 83 2006年1月

Transforming growth factor-β1 regulates cell growth and causes downregulation of SMemb/non-muscle myosin heavy chain B mRNA in human prostate stromal cells 査読

Kenji Obara, Vladimir Bilim, Kazuya Suzuki, Kazuhiro Kobayashi, Noboru Hara, Takashi Kasahara, Tsutomu Nishiyama, Kota Takahashi

Scandinavian Journal of Urology and Nephrology 39 ( 5 ) 366 - 371 2005年

腹腔鏡下骨盤内手術時の術中陰茎海綿体神経モニタリング

小林和博, 西山勉, 車田茂徳, 渡辺竜助, 郷秀人, 黒川公平, 星井達彦, 小原健司, 若月俊二, 谷川俊貴, 高橋公太

日本泌尿器科学会雑誌 95 ( 2 ) 402 - 402 2004年3月

Inducible Nitric Oxide Synthase in Renal Cell Carcinoma: Expression in Tumor Thrombi and Induction under Hypoxic Conditions 査読

Noboru Hara, Vladimir Bilim, Takashi Kasahara, Kenji Obara, Kazuhide Saito, Kota Takahashi, Yoshihiko Tomita

Anticancer Research 23 ( 6 C ) 4641 - 4649 2003年11月

von Hippel-Lindau病に合併した両側褐色細胞腫,異時性両側腎細胞癌の1例

鈴木一也, 小瀬川悦子, 星井達彦, 宮島憲生, 高橋英祐, 渡辺竜助, 小原健司, 冨田善彦, 高橋公太, 吉田実, 矢尾正祐

日本泌尿器科学会雑誌 93 ( 6 ) 710 - 714 2002年9月

記述言語：日本語出版者・発行元：(一社)日本泌尿器科学会

症例は38歳男で,2年9ヶ月前,両側副腎褐色細胞腫に対して副腎切除術を行った.2年4ヶ月前に左腎腫瘍を認め,左腎部分切除術を施行した.病理所見は腎細胞癌で,遺伝子解析ではcodon167番のmissense変異が同定された.8ヶ月前,右腎腫瘍を認めたが,拡張型心筋症に伴う心機能低下のため手術は困難と考え,現在経過観察中である

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2002&ichushi_jid=J01175&link_issn=&doc_id=20021002090008&doc_link_id=110003060635&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F110003060635&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

[Bilateral pheochromocytomas and asynchronous bilateral renal cell carcinomas associated with von Hippel-Lindau disease: a case report].

Kazuya Suzuki, Etsuko Kosegawa, Tatsuhiko Hoshii, Norio Miyajima, Eisuke Takahashi, Ryusuke Watanabe, Kenji Obara, Yoshihiko Tomita, Kohta Takahashi, Minoru Yoshida, Masahiro Yao

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 93 ( 6 ) 710 - 4 2002年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）

A 38-year-old man who had been followed with diagnosis of dilated cardiomyopathy and retinal angioma was referred to our hospital because of incidentally detected bilateral adrenal masses. Although he was normotensive, levels of catecholamine in urine were elevated and I131-MIBG scintigraphy showed accumulation in bilateral adrenal glands. Screening of central nervous system by MRI revealed cerebellar hemangioblastoma. Right adrenalectomy and left partial adrenalectomy were performed, both of which tumors pathologically diagnosed as pheochromocytoma, followed by resection of the cerebellar hemangioblastoma. Five months later, abdominal CT revealed a left renal tumor and underwent left partial nephrectomy, being diagnosed as renal cell carcinoma. A right renal tumor was detected on follow up CT at 1 year after the partial nephrectomy. Since cardiac function was deteriorated, we have followed with careful observation. This is the second documented case of bilateral renal cell carcinomas and bilateral pheochromocytomas with VHL in Japan.

PubMed

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Reverse transcription-polymerase chain reaction detection of prostate-specific antigen, prostate-specific membrane antigen, and prostate stem cell antigen in one milliliter of peripheral blood: Value for the staging of prostate cancer 査読

Noboru Hara, Takashi Kasahara, Takashi Kawasaki, Vladimir Bilim, Kenji Obara, Kota Takahashi, Yoshihiko Tomita

Clinical Cancer Research 8 ( 6 ) 1794 - 1799 2002年

Sequential detection of alphafetoprotein-bearing cells in blood stem cell fraction of germ cell tumour patients

T. Kasahara, N. Hara, V. Bilim, Y. Tomita, K. Saito, K. Obara, K. Takahashi

British Journal of Cancer 85 ( 8 ) 1119 - 1123 2001年10月

Frequency of PSA-mRNA-bearing cells in the peripheral blood of patients after prostate biopsy

N. Hara, T. Kasahara, T. Kawasaki, V. Bilim, Y. Tomita, K. Obara, K. Takahashi

British Journal of Cancer 85 ( 4 ) 557 - 562 2001年8月

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