Updated on 2024/03/28

写真a

 
ISHIKAWA Hiroyuki
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Professor
Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Professor
Title
Professor
External link

Degree

  • 医学博士 ( 2004.3   新潟大学 )

Research Areas

  • Life Science / Radiological sciences

Research History

  • Niigata University   Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine Molecular Genetics   Professor

    2020.9

  • Niigata University   Graduate School of Medical and Dental Sciences Biomedical Sciences   Lecturer

    2012.11

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control   Lecturer

    2012.11

  • Niigata University   University Medical and Dental Hospital Diagnostic Radiology   Lecturer

    2012.11 - 2020.8

  • Niigata University   University Medical and Dental Hospital Radiology   Lecturer

    2012.4 - 2012.11

  • Niigata University   University Medical and Dental Hospital   Assistant Professor

    2004.4 - 2012.3

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Professional Memberships

 

Papers

  • Prediction of patient‐specific quality assurance for volumetric modulated arc therapy using radiomics‐based machine learning with dose distribution Reviewed

    Natsuki Ishizaka, Tomotaka Kinoshita, Madoka Sakai, Shunpei Tanabe, Hisashi Nakano, Satoshi Tanabe, Sae Nakamura, Kazuki Mayumi, Shinya Akamatsu, Takayuki Nishikata, Takeshi Takizawa, Takumi Yamada, Hironori Sakai, Motoki Kaidu, Ryuta Sasamoto, Hiroyuki Ishikawa, Satoru Utsunomiya

    Journal of Applied Clinical Medical Physics   2023.11

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    DOI: 10.1002/acm2.14215

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  • Deep learning‐based detection and classification of multi‐leaf collimator modeling errors in volumetric modulated radiation therapy

    Sae Nakamura, Madoka Sakai, Natsuki Ishizaka, Kazuki Mayumi, Tomotaka Kinoshita, Shinya Akamatsu, Takayuki Nishikata, Shunpei Tanabe, Hisashi Nakano, Satoshi Tanabe, Takeshi Takizawa, Takumi Yamada, Hironori Sakai, Motoki Kaidu, Ryuta Sasamoto, Hiroyuki Ishikawa, Satoru Utsunomiya

    Journal of Applied Clinical Medical Physics   2023.8

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Purpose

    The purpose of this study was to create and evaluate deep learning‐based models to detect and classify errors of multi‐leaf collimator (MLC) modeling parameters in volumetric modulated radiation therapy (VMAT), namely the transmission factor (TF) and the dosimetric leaf gap (DLG).

    Methods

    A total of 33 clinical VMAT plans for prostate and head‐and‐neck cancer were used, assuming a cylindrical and homogeneous phantom, and error plans were created by altering the original value of the TF and the DLG by ± 10, 20, and 30% in the treatment planning system (TPS). The Gaussian filters of and 1.0 were applied to the planar dose maps of the error‐free plan to mimic the measurement dose map, and thus dose difference maps between the error‐free and error plans were obtained. We evaluated 3 deep learning‐based models, created to perform the following detections/classifications: (1) error‐free versus TF error, (2) error‐free versus DLG error, and (3) TF versus DLG error. Models to classify the sign of the errors were also created and evaluated. A gamma analysis was performed for comparison.

    Results

    The detection and classification of TF and DLG error were feasible for ; however, a considerable reduction of accuracy was observed for depending on the magnitude of error and treatment site. The sign of errors was detectable by the specifically trained models for and 1.0. The gamma analysis could not detect errors.

    Conclusions

    We demonstrated that the deep learning‐based models could feasibly detect and classify TF and DLG errors in VMAT dose distributions, depending on the magnitude of the error, treatment site, and the degree of mimicked measurement doses.

    DOI: 10.1002/acm2.14136

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  • Verification of Qfix Encompass™ couch modeling using the Acuros XB algorithm and HypeArc™ using a high-spatial-resolution two-dimensional diode array. International journal

    Takumi Yamada, Hisashi Nakano, Satoshi Tanabe, Tatsuya Sakai, Shunpei Tanabe, Tetsuya Oka, Hironori Sakai, Tomoya Oshikane, Toshimichi Nakano, Atsushi Ohta, Tsutomu Kanazawa, Motoki Kaidu, Hiroyuki Ishikawa

    Medical dosimetry : official journal of the American Association of Medical Dosimetrists   2023.7

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    We modeled the Qfix Encompass™ immobilization system and further verified the calculated dose distribution of the AcurosXB (AXB) dose calculation algorithm using SRS MapCHECKⓇ (SRSMC) in the HyperArc™ (HA) clinical plan. An Encompass system with a StereoPHAN™ QA phantom was scanned by SOMATOM go.Sim and imported to an Eclipse™ treatment planning system to create a treatment plan for Encompass modeling. The Encompass modeling was performed in the StereoPHAN with a pinpoint ion chamber for 6 MV and 6 MV flattening filter free (6 MV FFF), and 2 × 2 cm2, 4 × 4 cm2, and 6 × 6 cm2 irradiation field sizes. The dose calculation algorithm used was AXB ver. 15.5 with a 1.0 mm calculation grid size. The Hounsfield unit (HU) values of the Encompass modeling were set to 400, -100, -200, and -300 for Encompass, and -400, -600, -700, and -800 for the Encompass base. We evaluated the dose distribution after Encompass modeling by SRSMC using gamma analysis in 12 patients. We adopted HU values of -200 for Encompass, -800 for Encompass base for 6 MV, and -200 for Encompass and -700 for Encompass. Base for 6 MV FFF was adopted as the HU values for the Encompass modeling based on the measurement results. The proposed Encompass modeling resulted in a mean pass rate evaluation >98% for both 6 MV and 6 MV FFF when the 1%/1 mm criterion was used, demonstrating that the proposed HU value can be adopted to calculate more accurate dose distributions.

    DOI: 10.1016/j.meddos.2023.06.002

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  • Multicomponent mathematical model for tumor volume calculation with setup error using single-isocenter stereotactic radiotherapy for multiple brain metastases

    Hisashi Nakano, Takehiro Shiinoki, Satoshi Tanabe, Toshimichi Nakano, Takeshi Takizawa, Satoru Utsunomiya, Madoka Sakai, Shunpei Tanabe, Atsushi Ohta, Motoki Kaidu, Teiji Nishio, Hiroyuki Ishikawa

    Physical and Engineering Sciences in Medicine   2023.3

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s13246-023-01241-8

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    Other Link: https://link.springer.com/article/10.1007/s13246-023-01241-8/fulltext.html

  • Radiobiological evaluation considering the treatment time with stereotactic radiosurgery for brain metastases Reviewed

    Hisashi Nakano, Takeshi Takizawa, Daisuke Kawahara, Satoshi Tanabe, Satoru Utsunomiya, Motoki Kaidu, Katsuya Maruyama, Shigekazu Takeuchi, Kiyoshi Onda, Masahiko Koizumi, Teiji Nishio, Hiroyuki Ishikawa

    BJR|Open   2022.12

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    Publishing type:Research paper (scientific journal)   Publisher:British Institute of Radiology  

    Objective:

    We evaluated the radiobiological effect of the irradiation time with the interruption time of stereotactic radiosurgery (SRS) using CyberKnife<sup>®</sup> (CK) systemfor brain metastases.

    Methods:

    We used the DICOM data and irradiation log file of the 10 patients with brain metastases from non–small-cell lung cancer (NSCLC) who underwent brain SRS. We defined the treatment time as the sum of the dose–delivery time and the interruption time during irradiations, and we used a microdosimetric kinetic model (MKM) to evaluate the radiobiological effects of the treatment time. The biological parameters, i.e. α<sub>0</sub>, β<sub>0</sub>, and the DNA repair constant rate (a + c), were acquired from NCI-H460 cell for the MKM. We calculated the radiobiological dose for the gross tumor volume (GTV<sub>bio</sub>) to evaluate the treatment time’s effect compared with no treatment time as a reference. The D95 (%) and the Radiation Therapy Oncology Group conformity index (RCI) and Paddick conformity index (PCI) were calculated as dosimetric indices. We used several DNA repair constant rates (a + c) (0.46, 1.0, and 2.0) to assess the radiobiological effect by varying the DNA repair date (a + c) values.

    Results:

    The mean values of D95 (%), RCI, and PCI for GTV<sub>bio</sub> were 98.8%, 0.90, and 0.80, respectively, and decreased with increasing treatment time. The mean values of D95 (%), RCI, and PCI of GTV<sub>bio</sub> at 2.0 (a+c) value were 94.9%, 0.71, and 0.49, respectively.

    Conclusion:

    The radiobiological effect of the treatment time on tumors was accurately evaluated with brain SRS using CK.

    Advances in knowledge:

    There has been no published investigation of the radiobiological impact of the longer treatment time with multiple interruptions of SRS using a CK on the target dose distribution in a comparison with the use of a linac. Radiobiological dose assessment that takes into account treatment time in the physical dose in this study may allow more accurate dose assessment in SRS for metastatic brain tumors using CK.

    DOI: 10.1259/bjro.20220013

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  • The impact of target positioning error and tumor size on radiobiological parameters in robotic stereotactic radiosurgery for metastatic brain tumors.

    Takeshi Takizawa, Satoshi Tanabe, Hisashi Nakano, Satoru Utsunomiya, Madoka Sakai, Katsuya Maruyama, Shigekazu Takeuchi, Toshimichi Nakano, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa, Kiyoshi Onda

    Radiological physics and technology   2022.3

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    This study aimed to evaluate the effect of target positioning error (TPE) on radiobiological parameters, such as tumor control probability (TCP) and normal tissue complication probability (NTCP), in stereotactic radiosurgery (SRS) for metastatic brain tumors of different sizes using CyberKnife. The reference SRS plans were created using the circular cone of the CyberKnife for each spherical gross tumor volume (GTV) with diameters (φ) of 5, 7.5, 10, 15, and 20 mm, contoured on computed tomography images of the head phantom. Subsequently, plans involving TPE were created by shifting the beam center by 0.1-2.0 mm in three dimensions relative to the reference plans using the same beam arrangements. Conformity index (CI), generalized equivalent uniform dose (gEUD)-based TCP, and NTCP of estimated brain necrosis were evaluated for each plan. When the gEUD parameter "a" was set to - 10, the CI and TCP for the reference plan at the φ5-mm GTV were 0.90 and 80.8%, respectively. The corresponding values for plans involving TPE of 0.5-mm, 1.0-mm, and 2.0-mm were 0.62 and 77.4%, 0.40 and 62.9%, and 0.12 and 7.2%, respectively. In contrast, the NTCP for all GTVs were the same. The TCP for the plans involving a TPE of 2-mm was 7.2% and 68.8% at the φ5-mm and φ20-mm GTV, respectively. The TPEs corresponding to a TCP reduction rate of 3% at the φ5-mm and φ20-mm GTV were 0.41 and 0.99 mm, respectively. TPE had a significant effect on TCP in SRS for metastatic brain tumors using CyberKnife, particularly for small GTVs.

    DOI: 10.1007/s12194-022-00655-5

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  • 画像診断と病理 低異型度子宮内膜間質肉腫

    布澤 悠磨, 田崎 章子, 石川 浩志, 本山 悌一, 大橋 瑠子, 近藤 修平

    画像診断   42 ( 1 )   4 - 5   2021.12

  • Subsequent systemic therapy for non-small cell lung cancer patients with immune checkpoint inhibitor-related interstitial lung disease. International journal

    Yusuke Sato, Satoshi Watanabe, Takeshi Ota, Kohei Kushiro, Toshiya Fujisaki, Miho Takahashi, Aya Ohtsubo, Satoshi Shoji, Koichiro Nozaki, Kosuke Ichikawa, Satoshi Hokari, Rie Kondo, Masachika Hayashi, Hiroyuki Ishikawa, Takao Miyabayashi, Tetsuya Abe, Satoru Miura, Hiroshi Tanaka, Masaaki Okajima, Masaki Terada, Takashi Ishida, Akira Iwashima, Kazuhiro Sato, Hirohisa Yoshizawa, Nobumasa Aoki, Yasuyoshi Ohshima, Toshiyuki Koya, Toshiaki Kikuchi

    Translational lung cancer research   10 ( 7 )   3132 - 3143   2021.7

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    Background: Although immune checkpoint inhibitors (ICIs) are effective for advanced non-small cell lung cancer (NSCLC), ICIs may cause interstitial lung disease (ILD), which results in treatment discontinuation and is sometimes fatal. Despite the high incidence of ICI-related ILD, there are few cancer treatment options for patients. This study aimed to evaluate the safety and efficacy of subsequent systemic cancer therapy in NSCLC patients with ICI-related ILD. Methods: We retrospectively assessed NSCLC patients who received programmed cell death-1 (PD-1) inhibitors as first- to third-line therapy at participating institutions of the Niigata Lung Cancer Treatment Group from January 2016 to October 2017. Results: This analysis included 231 patients, 32 (14%) of whom developed ICI-related ILD. Of these patients, 16 (7%) received subsequent systemic cancer treatments. The median overall survival (OS) tended to be longer in the systemic cancer therapy group than in the no systemic cancer therapy group [22.2 months (95% CI: 1-NE) vs. 4.5 months (95% CI: 1-NE); P=0.067]. ICI-related ILD recurred in half of the patients who received systemic cancer therapy, and the median OS tended to be shorter in patients with recurrent ICI-related ILD [22.0 months (95% CI: 1-NE) vs. 7.0 months (95% CI: 1-NE); P=0.3154]. Conclusions: According to the current study, systemic cancer treatment is effective in patients with ICI-related ILD; however, its safety is uncertain because of the high risk of ICI-related ILD recurrence and poor survival outcome following ILD recurrence.

    DOI: 10.21037/tlcr-21-198

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  • Radiobiological evaluation considering setup error on single‐isocenter irradiation in stereotactic radiosurgery

    Hisashi Nakano, Satoshi Tanabe, Ryuta Sasamoto, Takeshi Takizawa, Satoru Utsunomiya, Madoka Sakai, Toshimichi Nakano, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    Journal of Applied Clinical Medical Physics   22 ( 7 )   266 - 275   2021.6

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    DOI: 10.1002/acm2.13322

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/acm2.13322

  • A comparative study of high-dose-rate brachytherapy boost combined with external beam radiation therapy versus external beam radiation therapy alone for high-risk prostate cancer Reviewed International journal

    Tomoya Oshikane, Motoki Kaidu, Eisuke Abe, Atsushi Ohta, Hirotake Saito, Toshimichi Nakano, Moe Honda, Satoshi Tanabe, Satoru Utsunomiya, Ryuta Sasamoto, Fumio Ishizaki, Takashi Kasahara, Tsutomu Nishiyama, Yoshihiko Tomita, Hidefumi Aoyama, Hiroyuki Ishikawa

    Journal of Radiation Research   62 ( 3 )   525 - 532   2021.5

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    <title>Abstract</title>
    We aimed to compare the outcomes of high-dose-rate brachytherapy (HDR-BT) boost and external beam radiation therapy (EBRT) alone for high-risk prostate cancer. This was a single-center, retrospective and observational study. Consecutive patients who underwent initial radical treatment by HDR-BT boost or EBRT alone from June 2009 to May 2016 at the Niigata University Medical and Dental Hospital, Japan were included. A total of 96 patients underwent HDR-BT boost, and 61 underwent EBRT alone. The prescription dose of HDR-BT boost was set to 18 Gy twice a day with EBRT 39 Gy/13 fractions. The dose for EBRT alone was mostly 70 Gy/28 fractions. The high-risk group received &amp;gt;6 months of prior androgen deprivation therapy. Overall survival, biochemical-free survival, local control and distant metastasis-free survival rates at 5 years were analyzed. The incidence of urological and gastrointestinal late adverse events of Grade 2 and above was also summarized. In the National Comprehensive Cancer Network (NCCN) high-risk calssification, HDR-BT boost had a significantly higher biochemical-free survival rate at 5 years (98.9% versus 90.7%, P = 0.04). Urethral strictures were more common in the HDR-BT boost group. We will continuously observe the progress of the study patients and determine the longer term results.

    DOI: 10.1093/jrr/rrab006

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  • Preoperative CT Findings for Predicting Acute Exacerbation of Interstitial Pneumonia After Lung Cancer Surgery: A Multicenter Case-Control Study Reviewed International journal

    Yoshiyuki Ozawa, Yuta Shibamoto, Marehiko Hiroshima, Motoo Nakagawa, Asami Ono, Ryota Hanaoka, Asako Yamamoto, Junya Tominaga, Hiroshi Kawada, Mitsuhiro Koyama, Koji Takumi, Maho Tsubakimoto, Ryoko Egashira, Fumiyasu Tsushima, Yasuka Kikuchi, Yuichiro Izumi, Takasuke Ushio, Masatoshi Kimura, Shintaro Ichikawa, Noriko Kitamura, Shoichiro Matsushita, Kenzo Okauchi, Toshihiro O'uchi, Hiroyuki Ishikawa, Masanori Kitase

    American Journal of Roentgenology   217 ( 4 )   859 - 869   2021.4

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    BACKGROUND. Acute exacerbation (AE) is a life-threatening complication of inter-stitial pneumonia (IP). Thoracic surgery may trigger AE. OBJECTIVE. The purpose of this study is to explore the role of preoperative CT findings in predicting postoperative AE in patients with IP and lung cancer. METHODS. This retrospective case-control study included patients from 22 institutions who had IP and underwent thoracic surgery for lung cancer. AE was diagnosed on the basis of symptoms and imaging findings noted within 30 days after surgery and the absence of alternate causes. For each patient with AE, two control patients without AE were identified. After exclusions, the study included 92 patients (78 men and 14 women; 31 with AE [the AE group] and 61 without AE [the no-AE group]; mean age, 72 years). Two radiologists independently reviewed preoperative thin-slice CT examinations for pulmonary findings and resolved differences by consensus. The AE and no-AE groups were compared using the Fisher exact and Mann-Whitney U tests. Multivariable logistic regression was performed. Interreader agreement was assessed by kappa coefficients. RESULTS. A total of 94% of patients in the AE group underwent segmentectomy or other surgery that was more extensive than wedge resection versus 75% in the no-AE group (p = .046). The usual IP pattern was present in 58% of the AE group versus 74% of the no-AE group (p = .16). According to subjective visual scoring, the mean (± SD) ground-glass opacity (GGO) extent was 6.3 ± 5.4 in the AE group versus 3.9 ± 3.8 in the no-AE group (p = .03), and the mean consolidation extent was 0.5 ± 1.2 in the AE group versus 0.1 ± 0.3 in the no-AE group (p = .009). Mean pulmonary trunk diameter was 28 ± 4 mm in the AE group versus 26 ± 3 mm in the no-AE group (p = .02). In a model of CT features only, independent predictors of AE (p < .05) were GGO extent (odds ratio [OR], 2.8), consolidation extent (OR, 9.4), and pulmonary trunk diameter (OR, 4.2); this model achieved an AUC of 0.75, a PPV of 71%, and an NPV of 77% for AE. When CT and clinical variables were combined, undergoing segmentectomy or more extensive surgery also independently predicted AE (OR, 8.2; p = .02). CONCLUSION. The presence of GGO, consolidation, and pulmonary trunk enlargement on preoperative CT predicts AE in patients with IP who are undergoing lung cancer surgery. CLINICAL IMPACT. Patients with IP and lung cancer should be carefully managed when predictive CT features are present. Wedge resection, if possible, may help reduce the risk of AE in these patients. TRIAL REGISTRATION. University Hospital Medical Information Clinical Trial Registry UMIN000029661.

    DOI: 10.2214/ajr.21.25499

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  • Low Tube Voltage Computed Tomography Venography for Patients With Deep Vein Thrombosis of the Lower Extremities ― A Comparison With Venous Ultrasonography ― Reviewed

    Tatsuhiko Sato, Norihiko Yoshimura, Yosuke Horii, Motohiko Yamazaki, Ken Sato, Kazuki Kumagai, Hiroyuki Ishikawa

    Circulation Journal   85 ( 4 )   369 - 376   2021.3

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Circulation Society  

    BACKGROUND: Low tube voltage computed tomography venography (CTV) can be expected to increase imaging contrast and decrease radiation exposure by using iterative reconstruction (IR). This study evaluated the diagnostic ability of low tube voltage CTV with IR for deep vein thrombosis (DVT), compared to ultrasonography (US).Methods and Results:Two experienced radiologists retrospectively reevaluated the CTV data of 55 of 318 consecutive patients suspected of having DVT or pulmonary embolism between December 2015 and April 2017. The 55 patients had undergone both low tube voltage CTV and US (within 1 day before or after CTV). The lower extremity veins were divided into 10 segments. The DVT forms were categorized into 3 types: complete, concentric, and eccentric. We analyzed the 534 overall segments (16 segments excluded in US) measured using both CTV and US. The sensitivity-specificity was overall 73.3-90.0%, for femoropopliteal, it was 90.0-93.2%, and for the calf, it was 71.1-87.2%. The diagnostic accuracy between the 'eccentric only' and 'others' groups focusing on DVT forms was compared, and significant differences were revealed, especially in the muscular vein. CONCLUSIONS: The DVT diagnostic ability above the knee was comparable between low tube voltage CTV with IR and conventional CTV, and the radiation dose was reduced. It was suggested that eccentric DVT measured by CTV tend to be a false-positive, especially in the calf muscular vein.

    DOI: 10.1253/circj.cj-20-0416

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  • Detecting MLC modeling errors using radiomics‐based machine learning in patient‐specific QA with an EPID for intensity‐modulated radiation therapy Reviewed International journal

    Madoka Sakai, Hisashi Nakano, Daisuke Kawahara, Satoshi Tanabe, Takeshi Takizawa, Akihiro Narita, Takumi Yamada, Hironori Sakai, Masataka Ueda, Ryuta Sasamoto, Motoki Kaidu, Hidefumi Aoyama, Hiroyuki Ishikawa, Satoru Utsunomiya

    Medical Physics   48 ( 3 )   991 - 1002   2021.3

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    PURPOSE: We sought to develop machine learning models to detect multileaf collimator (MLC) modeling errors with the use of radiomic features of fluence maps measured in patient-specific quality assurance (QA) for intensity-modulated radiation therapy (IMRT) with an electric portal imaging device (EPID). METHODS: Fluence maps measured with EPID for 38 beams from 19 clinical IMRT plans were assessed. Plans with various degrees of error in MLC modeling parameters [i.e., MLC transmission factor (TF) and dosimetric leaf gap (DLG)] and plans with an MLC positional error for comparison were created. For a total of 152 error plans for each type of error, we calculated fluence difference maps for each beam by subtracting the calculated maps from the measured maps. A total of 837 radiomic features were extracted from each fluence difference map, and we determined the number of features used for the training dataset in the machine learning models by using random forest regression. Machine learning models using the five typical algorithms [decision tree, k-nearest neighbor (kNN), support vector machine (SVM), logistic regression, and random forest] for binary classification between the error-free plan and the plan with the corresponding error for each type of error were developed. We used part of the total dataset to perform fourfold cross-validation to tune the models, and we used the remaining test dataset to evaluate the performance of the developed models. A gamma analysis was also performed between the measured and calculated fluence maps with the criteria of 3%/2 and 2%/2 mm for all of the types of error. RESULTS: The radiomic features and its optimal number were similar for the models for the TF and the DLG error detection, which was different from the MLC positional error. The highest sensitivity was obtained as 0.913 for the TF error with SVM and logistic regression, 0.978 for the DLG error with kNN and SVM, and 1.000 for the MLC positional error with kNN, SVM, and random forest. The highest specificity was obtained as 1.000 for the TF error with a decision tree, SVM, and logistic regression, 1.000 for the DLG error with a decision tree, logistic regression, and random forest, and 0.909 for the MLC positional error with a decision tree and logistic regression. The gamma analysis showed the poorest performance in which sensitivities were 0.737 for the TF error and the DLG error and 0.882 for the MLC positional error for 3%/2 mm. The addition of another type of error to fluence maps significantly reduced the sensitivity for the TF and the DLG error, whereas no effect was observed for the MLC positional error detection. CONCLUSIONS: Compared to the conventional gamma analysis, the radiomics-based machine learning models showed higher sensitivity and specificity in detecting a single type of the MLC modeling error and the MLC positional error. Although the developed models need further improvement for detecting multiple types of error, radiomics-based IMRT QA was shown to be a promising approach for detecting the MLC modeling error.

    DOI: 10.1002/mp.14699

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mp.14699

  • Maximum distance in single-isocenter technique of stereotactic radiosurgery with rotational error using margin-based analysis Reviewed

    Hisashi Nakano, Satoshi Tanabe, Takumi Yamada, Satoru Utsunomiya, Takeshi Takizawa, Madoka Sakai, Ryuta Sasamoto, Hironori Sakai, Toshimichi Nakano, Hirotake Saito, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    Radiological Physics and Technology   14 ( 1 )   57 - 63   2021.3

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s12194-020-00602-2

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  • Calculated relative biological effectiveness (RBE) for initial DNA double-strand breaks (DSB) from flattening filter and flattening filter-free 6 MV X-ray fields Reviewed

    Hisashi Nakano, Daisuke Kawahara, Satoshi Tanabe, Satoru Utsunomiya, Takeshi Takizawa, Madoka Sakai, Toshimichi Nakano, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    BJR|Open   3 ( 1 )   20200072 - 20200072   2021.1

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    <sec><title>Objectives:</title> We evaluated the radiobiological effectiveness based on the yields of DNA double-strand breaks (DSBs) of field induction with flattening filter (FF) and FF-free (FFF) photon beams.

    </sec><sec><title>Methods:</title> We used the particle and heavy ion transport system (PHITS) and a water equivalent phantom (30 × 30 × 30 cm<sup>3</sup>) to calculate the physical qualities of the dose-mean lineal energy (y<sub>D</sub>) with 6 MV FF and FFF. The relative biological effectiveness based on the yields of DNA-DSBs (RBE<sub>DSB</sub>) was calculated for standard radiation such as 220 kVp X-rays by using the estimating yields of SSBs and DSBs. The measurement points used to calculate the in-field y<sub>D</sub> and RBE<sub>DSB</sub> were located at a depth of 3, 5, and 10 cm in the water equivalent phantom on the central axis. Measurement points at 6, 8, and 10 cm in the lateral direction of each of the three depths from the central axis were set to calculate the out-of-field y<sub>D</sub> and RBE<sub>DSB</sub>.

    </sec><sec><title>Results:</title> The RBE<sub>DSB</sub> of FFF in-field was 1.7% higher than FF at each measurement depth. The RBE<sub>DSB</sub> of FFF out-of-field was 1.9 to 6.4% higher than FF at each depth measurement point. As the distance to out-of-field increased, the RBE<sub>DSB</sub> of FFF rose higher than those of FF. FFF has a larger RBE<sub>DSB</sub> than FF based on the yields of DNA-DSBs as the distance to out-of-field increased.

    </sec><sec><title>Conclusions:</title> The out-of-field radiobiological effect of FFF could thus be greater than that of FF since the spreading of the radiation dose out-of-field with FFF could be a concern compared to the FF.

    </sec><sec><title>Advances in knowledge:</title> The RBE<sub>DSB</sub> of FFF of out-of-field might be larger than FF.

    </sec>

    DOI: 10.1259/bjro.20200072

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  • Radiobiological effects of the interruption time with Monte Carlo Simulation on multiple fields in photon beams Reviewed International journal

    Hisashi Nakano, Daisuke Kawahara, Satoshi Tanabe, Satoru Utsunomiya, Takeshi Takizawa, Madoka Sakai, Hirotake Saito, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    Journal of Applied Clinical Medical Physics   21 ( 12 )   288 - 294   2020.12

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    PURPOSE: The interruption time is the irradiation interruption that occurs at sites and operations such as the gantry, collimator, couch rotation, and patient setup within the field in radiotherapy. However, the radiobiological effect of prolonging the treatment time by the interruption time for tumor cells is little evaluated. We investigated the effect of the interruption time on the radiobiological effectiveness with photon beams based on a modified microdosimetric kinetic (mMK) model. METHODS: The dose-mean lineal energy yD (keV/µm) of 6-MV photon beams was calculated by the particle and heavy ion transport system (PHITS). We set the absorbed dose to 2 or 8 Gy, and the interruption time (τ) was set to 1, 3, 5, 10, 30, and 60 min. The biological parameters such as α0, β0, and DNA repair constant rate (a + c) values were acquired from a human non-small-cell lung cancer cell line (NCI-H460) for the mMK model. We used two-field and four-field irradiation with a constant dose rate (3 Gy/min); the photon beams were paused for interruption time τ. We calculated the relative biological effectiveness (RBE) to evaluate the interruption time's effect compared with no interrupted as a reference. RESULTS: The yD of 6-MV photon beams was 2.32 (keV/µm), and there was little effect by changing the water depth (standard deviation was 0.01). The RBE with four-field irradiation for 8 Gy was decreased to 0.997, 0.975, 0.900, and 0.836 τ = 1, 10, 30, 60 min, respectively. In addition, the RBE was affected by the repair constant rate (a + c) value, the greater the decrease in RBE with the longer the interruption time when the (a + c) value was large. CONCLUSION: The ~10-min interruption of 6-MV photon beams did not significantly impact the radiobiological effectiveness, since the RBE decrease was <3%. Nevertheless, the RBE's effect on tumor cells was decreased about 30% by increasing the 60 min interruption time at 8 Gy with four-field irradiation. It is thus necessary to make the interruption time as short as possible.

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  • Prognostic significance of the radiologic features of pneumonitis induced by anti‐PD‐1 therapy Reviewed International journal

    Satoshi Watanabe, Takeshi Ota, Masachika Hayashi, Hiroyuki Ishikawa, Aya Otsubo, Satoshi Shoji, Koichiro Nozaki, Kosuke Ichikawa, Rie Kondo, Takao Miyabayashi, Satoru Miura, Hiroshi Tanaka, Tetsuya Abe, Masaaki Okajima, Masaki Terada, Takashi Ishida, Akira Iwashima, Kazuhiro Sato, Hirohisa Yoshizawa, Toshiaki Kikuchi

    Cancer Medicine   9 ( 9 )   3070 - 3077   2020.5

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    BACKGROUND: Interstitial lung disease (ILD) induced by anti-programmed-cell death-1 (PD-1) and anti-PD-ligand 1 (PD-L1) is potentially life-threatening and is a common reason of the discontinuation of therapy. In contrast, an enhancement in antitumor effects was reported in patients who developed immune-related adverse events, including ILD. Although recent evidence suggests that radiologic patterns of ILD may reflect the severity of ILD and the antitumor immune responses to anti-PD-1/PD-L1 therapies, the association between radiologic features and clinical outcomes remains unclear. METHODS: Patients with advanced non-small-cell lung cancer who were treated with 1st to 3rd line anti-PD-1 therapy from January 2016 through October 2017 were identified at multiple institutions belonging to the Niigata Lung Cancer Treatment Group. ILD was diagnosed by the treating physicians, and chest computed tomography scans were independently reviewed to assess the radiologic features of ILD. RESULTS: A total of 231 patients who received anti-PD-1 therapy were enrolled. Thirty-one patients (14%) developed ILD. Sixteen patients were classified as having ground glass opacities (GGO), 16 were classified as having cryptogenic organizing pneumonia (COP), and one was classified as having pneumonitis not otherwise specified. Patients with GGO had significantly worse overall survival time compared to patients with COP (7.8 months (95% CI: 2.2-NE) versus not reached (95% CI: 13.2-NE); P = 0.0175). Multivariate analysis of all 231 patients also revealed that PS = 1 and ≥2 and GGO were significant predictors of a worse overall survival. CONCLUSIONS: This study demonstrated that patients who developed GGO exhibited worse outcomes among non-small-cell lung cancer patients receiving anti-PD-1 therapies.

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  • Quantitative 3D Shape Analysis of CT Images of Thymoma: A Comparison With Histological Types Reviewed International journal

    Motohiko Yamazaki, Kanako Oyanagi, Hajime Umezu, Takuya Yagi, Hiroyuki Ishikawa, Norihiko Yoshimura, Hidefumi Aoyama

    American Journal of Roentgenology   214 ( 2 )   341 - 347   2020.2

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    OBJECTIVE. The purpose of this study is to differentiate between low- and high-risk types of thymoma using quantitative 3D shape analysis of CT images. MATERIALS AND METHODS. This retrospective study included 44 patients with a pathologic diagnosis of thymoma. Two radiologists semiautomatically contoured CT images of the tumors and evaluated 3D shape parameters-namely, quantitative indicators of surface smoothness, including sphericity, ellipsoidality, and discrete compactness. The visual CT findings that were analyzed included longest diameter, shape (round-oval, lobulated, or irregular), calcification, cystic or necrotic changes, and enhancement pattern (homogeneous or heterogeneous). The difference and discriminating performance between low-risk (types A, AB, and B1) and high-risk (types B2 and B3) thymomas were statistically assessed. Interobserver agreement was determined using the concordance correlation coefficient. RESULTS. Twenty-three low-risk and 21 high-risk thymomas were identified on the basis of pathologic findings. The median values of sphericity and ellipsoidality were significantly higher for low-risk thymomas than for high-risk thymomas (for sphericity, 0.566 vs 0.517; for ellipsoidality, 0.941 vs 0.875; p < 0.05 for both). The AUC values of sphericity and ellipsoidality were 0.704 and 0.712, respectively. The best cutoff values were 0.528 and 0.919 for sphericity and ellipsoidality, respectively. Risk assessment combining these cutoff values and the mode of tumor detection (incidental detection or detection based on the presence of symptoms) improved the AUC value to 0.856 (sensitivity, 81.0% [17 of 21 patients]; specificity, 82.6% [19 of 23 patients]). All 3D shape parameters showed almost perfect interobserver agreement (concordance correlation coefficient, > 0.90). The visual CT findings were not significantly different between low- and high-risk thymomas (p > 0.05 for all). CONCLUSION. Quantitative 3D shape analysis has excellent reproducibility, and combining this technique with information on the detection mode helps differentiate low- from high-risk thymomas.

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  • 小型肺腺癌とすりガラス影

    石川浩志

    新潟県医師会報   ( 849 )   2 - 7   2020

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  • The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study Reviewed International journal

    Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Hiroyuki Ishikawa, Masanori Tsuchida

    BMC Pulmonary Medicine   19 ( 1 )   73 - 73   2019.12

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    BACKGROUND: The presence of emphysema on computed tomography (CT) is associated with an increased frequency of lung cancer, but the postoperative outcomes of patients with pulmonary emphysema are not well known. The objective of this study was to investigate the association between the extent of emphysema and long-term outcomes, as well as mortality and postoperative complications, in early-stage lung cancer patients after pulmonary resection. METHODS: The clinical records of 566 consecutive lung cancer patients who underwent pulmonary resection in our department were retrospectively reviewed. Among these, the data sets of 364 pathological stage I patients were available. The associations between the extent of lung emphysema and long-term outcomes and postoperative complications were investigated. Emphysema was assessed on the basis of semiquantitative CT. Surgery-related complications of Grade ≥ II according to the Clavien-Dindo classification were included in this study. RESULTS: Emphysema was present in 63 patients. The overall survival and relapse-free survival of the non-emphysema and emphysema groups at 5 years were 89.0 and 61.3% (P < 0.001), respectively, and 81.0 and 51.7%, respectively (P < 0.001). On multivariate analysis, significant prognostic factors were emphysema, higher smoking index, and higher histologic grade (p < 0.05). Significant risk factors for poor recurrence-free survival were emphysema, higher smoking index, higher histologic grade, and presence of pleural invasion (P < 0.05). Regarding Grade ≥ II postoperative complications, pneumonia and supraventricular tachycardia were more frequent in the emphysema group than in the non-emphysema group (P = 0.003 and P = 0.021, respectively). CONCLUSION: The presence of emphysema affects the long-term outcomes and the development of postoperative complications in early-stage lung cancer patients.

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  • Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study Reviewed International journal

    Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe, Masanori Tsuchida

    BMC Pulmonary Medicine   18 ( 1 )   134 - 134   2018.12

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    BACKGROUND: Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this study was to evaluate the surgical outcomes of repeated lung cancer surgery in patients with IPF. METHODS: From January 2001 to December 2015, 108 lung cancer patients with IPF underwent pulmonary resection at two institutions; 13 of these patients underwent repeated surgery for lung cancer, and their data were reviewed. RESULTS: The initial procedures of the 13 patients were lobectomy in 8, segmentectomy in 2, and wedge resection in 3. The subsequent procedures were wedge resection in 10 and segmentectomy in 3. The clinical stage of the second tumor was stage IA in 12 and stage IB in 1. Postoperatively, 3 patients (23.1%) developed acute exacerbation (AE) of IPF and died. The rate of decrease in percent vital capacity was significantly higher in patients with AE than in those without AE (p = 0.011). The 3-year overall survival rate was 34.6%. The causes of death were cancer-related in 7, AE of IPF in 3, and metachronous lung cancer in 1. CONCLUSIONS: Despite limited resection, a high incidence of AE was identified. The early and long-term outcomes of repeated surgery in lung cancer patients with IPF were poor because of the high risk of AE of IPF and lung cancer recurrence. Long-term intensive surveillance will be required to determine whether surgical intervention is justified in patients with multiple primary lung cancers and IPF.

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  • すりガラス結節とFDG陰性の充実性結節を呈した腺様嚢胞癌肺転移の一例

    本田 母映, 山崎 元彦, 八木 琢也, 石川 浩志, 吉村 宣彦, 青山 英史, 佐藤 征二郎, 小池 輝元, 土田 正則, 梅津 哉

    核医学   55 ( Suppl. )   S201 - S201   2018.11

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  • HRCT texture analysis for pure or part-solid ground-glass nodules: distinguishability of adenocarcinoma in situ or minimally invasive adenocarcinoma from invasive adenocarcinoma Reviewed

    Takuya Yagi, Motohiko Yamazaki, Riuko Ohashi, Rei Ogawa, Hiroyuki Ishikawa, Norihiko Yoshimura, Masanori Tsuchida, Yoichi Ajioka, Hidefumi Aoyama

    Japanese Journal of Radiology   36 ( 2 )   113 - 121   2018.2

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    PURPOSE: To distinguish between adenocarcinoma in situ (AIS)-minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) showing pure or part-solid ground-glass nodules (GGNs) by high-resolution computed tomography (HRCT) texture analysis. MATERIALS AND METHODS: This retrospective study included 101 consecutive patients with 115 pure or part-solid GGNs ≤ 3 cm diameter, which were surgically resected and pathologically diagnosed with AIS, MIA, or IAC (48 AIS-MIA and 67 IAC) between April 2011 and March 2015. Each tumor was manually segmented on axial CT images, and the following texture features were calculated: volume, mass, mean CT value, variance, skewness, kurtosis, entropy, uniformity, and percentile CT numbers (10th, 25th, 50th, 75th, 90th, 95th percentiles). The differences between AIS-MIA and IAC were statistically evaluated using univariate, multivariate, and receiver operating characteristic analysis. RESULTS: Compared with IAC, AIS-MIA had significantly greater skewness, kurtosis, and uniformity, whereas in the other parameters, AIS-MIA demonstrated significantly lower values than those of IAC. Multivariate analysis revealed that independent differentiators were the 90th percentile CT numbers (P < 0.001) and entropy (P = 0.005) with an excellent accuracy (area under the curve, 0.90). CONCLUSIONS: The 90th percentile CT numbers and entropy can accurately distinguish AIS-MIA from IAC.

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  • 肺動脈塞栓として初期治療を受け、18F FDG-PET/CTで鑑別できた肺動脈肉腫の1例

    山田 美佳, 佐藤 卓, 石川 浩志, 堀井 陽祐, 八木 琢也, 山崎 元彦, 塩谷 基, 吉村 宣彦, 青山 英史, 佐藤 征二郎, 小池 輝元, 土田 正則, 名村 理, 大橋 瑠子, 梅津 哉

    Japanese Journal of Radiology   36 ( Suppl. )   7 - 7   2018.2

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  • 多発肺結節を呈したメトトレキセート関連リンパ増殖性疾患の1例

    山名 加菜子, 山崎 元彦, 石川 浩志, 八木 琢也, 吉村 宣彦, 青山 英史, 坂上 拓郎, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則, 大橋 瑠子, 梅津 哉

    Japanese Journal of Radiology   35 ( Suppl. )   8 - 8   2017.2

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  • 若年者に発症し副結節をともなった硬化性血管腫の1例

    押金 智哉, 山崎 元彦, 石川 浩志, 八木 琢也, 吉村 宣彦, 青山 英史, 北原 哲彦, 佐藤 征二郎, 小池 輝元, 土田 正則, 大橋 瑠子, 梅津 哉

    Japanese Journal of Radiology   35 ( Suppl. )   8 - 8   2017.2

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  • Surgical Outcomes of Lung Cancer Patients with Combined Pulmonary Fibrosis and Emphysema and Those with Idiopathic Pulmonary Fibrosis without Emphysema Reviewed

    Seijiro Sato, Terumoto Koike, Takehisa Hashimoto, Hiroyuki Ishikawa, Akira Okada, Takehiro Watanabe, Masanori Tsuchida

    Annals of Thoracic and Cardiovascular Surgery   22 ( 4 )   216 - 223   2016

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    OBJECTIVES: Combined pulmonary fibrosis and emphysema (CPFE) is a unique disorder. The aim of this study was to compare the surgical outcomes of lung cancer patients with CPFE and those with idiopathic pulmonary fibrosis (IPF) without emphysema. METHODS: A total of 1548 patients who underwent surgery for primary lung cancer between January 2001 and December 2012 were retrospectively reviewed. RESULTS: Of the 1548 patients, 55 (3.6%) had CPFE on computed tomography (CT), and 45 (2.9%) had IPF without emphysema. The overall and disease-free 5-year survival rates for patients with CPFE were not significantly worse than those for patients with IPF without emphysema (24.9% vs. 36.8%, p = 0.814; 39.8% vs. 39.3%, p = 0.653, respectively). Overall, 21 (38.1%) patients with CPFE and nine patients (20.0%) with IPF without emphysema developed postoperative cardiopulmonary complications. Patients with CPFE had significantly more postoperative cardiopulmonary complications involving pulmonary air leakage for >6 days, hypoxemia, and arrhythmia than patients with IPF without emphysema (p = 0.048). CONCLUSIONS: There was no significant difference in survival after surgical treatment between CPFE patients and IPF patients without emphysema, but CPFE patients had significantly higher morbidity than IPF patients without emphysema.

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  • 画像診断の進歩 胸部画像診断:最近の話題

    石川浩志

    新潟医学会雑誌   129 ( 12 )   705 - 709   2015.12

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  • Ultra-High-Resolution Computed Tomography of the Lung: Image Quality of a Prototype Scanner Reviewed

    Ryutaro Kakinuma, Noriyuki Moriyama, Yukio Muramatsu, Shiho Gomi, Masahiro Suzuki, Hirobumi Nagasawa, Masahiko Kusumoto, Tomohiko Aso, Yoshihisa Muramatsu, Takaaki Tsuchida, Koji Tsuta, Akiko Miyagi Maeshima, Naobumi Tochigi, Shun-ichi Watanabe, Naoki Sugihara, Shinsuke Tsukagoshi, Yasuo Saito, Masahiro Kazama, Kazuto Ashizawa, Kazuo Awai, Osamu Honda, Hiroyuki Ishikawa, Naoya Koizumi, Daisuke Komoto, Hiroshi Moriya, Seitaro Oda, Yasuji Oshiro, Masahiro Yanagawa, Noriyuki Tomiyama, Hisao Asamura

    PLOS ONE   10 ( 9 )   e0137165 - e0137165   2015.9

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  • A combination of preoperative CT findings and postoperative serum CEA levels improves recurrence prediction for stage I lung adenocarcinoma Reviewed International journal

    Motohiko Yamazaki, Hiroyuki Ishikawa, Ryosuke kunii, Akiko Tasaki, Suguru Sato, Yohei Ikeda, Norihiko Yoshimura, Takehisa Hashimoto, Masanori Tsuchida, Hidefumi Aoyama

    European Journal of Radiology   84 ( 1 )   178 - 184   2015.1

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    OBJECTIVES: To assess the prognostic value of combined evaluation of preoperative CT findings and pre/postoperative serum carcinoembryonic antigen (CEA) levels for pathological stage I lung adenocarcinoma. METHODS: This retrospective study included 250 consecutive patients who underwent complete resection for ≤ 3-cm pathological stage I (T1-2aN0M0) adenocarcinomas (132 men, 118 women; mean age, 67.8 years). Radiologists evaluated following CT findings: maximum tumor diameter, percentage of solid component (%solid), air bronchogram, spiculation, adjacency of bullae or interstitial pneumonia (IP) around the tumor, notch, and pleural indent. These CT findings, pre/postoperative CEA levels, age, gender, and Brinkman index were assessed by Cox proportional hazards model to determine the best prognostic model. Prognostic accuracy was examined using the area under the receiver operating characteristic curve (AUC). RESULTS: Median follow-up period was 73.2 months. In multivariate analysis, high %solid, adjacency of bullae or IP around the tumor, and high postoperative CEA levels comprised the best combination for predicting recurrence (P<0.05). A combination of these three findings had a greater accuracy in predicting 5-year disease-free survival than did %solid alone (AUC=0.853 versus 0.792; P=0.023), with a sensitivity of 85.7% and a specificity of 74.3% at the optimal threshold. The best cut-off values of %solid and postoperative CEA levels for predicting high-risk patients were ≥ 48% and ≥ 3.7 ng/mL, respectively. CONCLUSION: Compared to %solid alone, combined evaluation of %solid, adjacency of bullae or IP change around the tumor, and postoperative CEA levels improves recurrence prediction for stage I lung adenocarcinoma.

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  • Analysis of decrease in lung perfusion blood volume with occlusive and non-occlusive pulmonary embolisms Reviewed

    Yohei Ikeda, Norihiko Yoshimura, Yoshiro Hori, Yosuke Horii, Hiroyuki Ishikawa, Motohiko Yamazaki, Yoshiyuki Noto, Hidefumi Aoyama

    European Journal of Radiology   83 ( 12 )   2260 - 2267   2014.12

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  • Relationship between CT features and high preoperative serum carcinoembryonic antigen levels in early-stage lung adenocarcinoma Reviewed International journal

    M. Yamazaki, H. Ishikawa, R. Kunii, A. Tasaki, S. Sato, Y. Ikeda, N. Yoshimura, H. Aoyama

    Clinical Radiology   69 ( 6 )   559 - 566   2014.6

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    AIM: To assess the relationship between thin-section computed tomography (CT) features of primary tumour and high preoperative serum carcinoembryonic antigen (CEA) levels that reportedly suggest poor prognoses in early-stage lung adenocarcinoma. MATERIALS AND METHODS: Two hundred and seventy-five consecutive patients who underwent resection of pathological stage I (T1-2aN0M0) adenocarcinomas with a maximum diameter of ≤ 3 cm (144 men, 131 women; mean age 67.8 years) were enrolled. CT features of the primary tumours and clinical characteristics of these patients were statistically evaluated to identify the factors associated with high serum CEA levels (>5 ng/ml). RESULTS: Eighty-one patients (29.5%) had high serum CEA levels. In univariate analysis, lower ground-glass opacity ratio (p < 0.001), lower tumour shadow disappearance rate (TDR: the ratio of tumour area in mediastinal window to that of lung window, p < 0.001), presence of notch (p = 0.015), and coexistence with bullae or honeycomb cysts (p < 0.001) were observed more frequently in the group with high serum CEA levels than that of the group with normal levels. TDR [odds ratio (OR) 0.984; 95% confidence interval (CI): 0.976-0.993; p < 0.001] and coexistence with bullae or honeycomb cysts (OR = 3.08; 95% CI: 1.55-6.12; p = 0.001) remained significant, even after adjusting patients' age, gender, and smoking status. CONCLUSIONS: Adenocarcinomas with lower TDR and coexisting with bullae or honeycomb cysts are associated with high preoperative serum CEA levels. Although some CEA elevations may be due to benign pulmonary diseases, such tumours are suspected to have poor prognoses, even for early-stage diseases.

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  • 肺塞栓症におけるLung PBVの血流低下域についての検討

    池田 洋平, 佐藤 卓, 山崎 元彦, 堀 祐郎, 石川 浩志, 吉村 宣彦, 青山 英史

    Japanese Journal of Radiology   32 ( Suppl. )   1 - 1   2014.2

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  • Where is the most common site of DVT? Evaluation by CT venography Reviewed

    Norihiko Yoshimura, Yoshiro Hori, Yosuke Horii, Toru Takano, Hiroyuki Ishikawa, Hidefumi Aoyama

    Japanese Journal of Radiology   30 ( 5 )   393 - 397   2012.6

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    DOI: 10.1007/s11604-012-0059-6

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  • Measurement of Focal Ground-glass Opacity Diameters on CT Images Reviewed

    Ryutaro Kakinuma, Kazuto Ashizawa, Keiko Kuriyama, Aya Fukushima, Hiroyuki Ishikawa, Hisashi Kamiya, Naoya Koizumi, Yuichiro Maruyama, Kazunori Minami, Norihisa Nitta, Seitaro Oda, Yasuji Oshiro, Masahiko Kusumoto, Sadayuki Murayama, Kiyoshi Murata, Yukio Muramatsu, Noriyuki Moriyama

    Academic Radiology   19 ( 4 )   389 - 394   2012.4

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  • 灌流CTによる肺癌の放射線治療に対する効果判定、および治療反応性の予測に関する研究

    國井亮祐, 川口 弦, 山崎元彦, 能登義幸, 石川浩志, 青山英史

    新潟県医師会報   ( 753 )   8 - 10   2012

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  • Ⅷ 腫瘍性疾患 E.その他腫瘍性病変 肺内リンパ節

    石川浩志

    別冊日本臨床 新領域別症候群シリーズ No.10   291 - 293   2009

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  • GGOと肺内リンパ節らしさと経時変化に着目した小病変(5-6mm以下)の鑑別法

    石川浩志

    CT検診   15 ( 3 )   138 - 142   2008

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  • Ultrasmall Intrapulmonary Lymph Node: Usual High-Resolution Computed Tomographic Findings With Histopathologic Correlation Reviewed

    Hiroyuki Ishikawa, Naoya Koizumi, Tetsuro Morita, Masanori Tsuchida, Hajime Umezu, Keisuke Sasai

    Journal of Computer Assisted Tomography   31 ( 3 )   409 - 413   2007.5

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    DOI: 10.1097/01.rct.0000243451.25986.10

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  • 胸部間接撮影による肺癌検診成績 高度に精度管理された地域での検討 Reviewed

    小田純一, 秋田眞一, 古泉直也, 塚田博, 谷由子, 木原好則, 森田哲郎, 石川浩志, 奥泉美奈, 栗田雄三

    肺癌   47 ( 6 )   707 - 715   2007

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  • Ultrasmall Pulmonary Opacities on Multidetector-Row High-Resolution Computed Tomography Reviewed

    Hiroyuki Ishikawa, Naoya Koizumi, Tetsuro Morita, Yoshiko Tani, Masanori Tsuchida, Hajime Umezu, Makoto Naito, Keisuke Sasai

    Journal of Computer Assisted Tomography   29 ( 5 )   621 - 625   2005.9

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    DOI: 10.1097/01.rct.0000172672.09564.8c

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  • 肺腺癌におけるNoguchiらの分類間の移行の数理生物学的検討 近似関数の推計 Reviewed

    古泉直也, 石川浩志, 笹井啓資, 歸山智治, 福本一朗, 菅野敬祐

    胸部CT検診   12 ( 2 )   231 - 237   2005

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  • Multidetector-row CTによる微小肺病変の高分解能CTと病理組織の対比

    石川浩志

    胸部CT検診   11 ( 2 )   83 - 86   2004

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  • 胸部画像診断 これだけ押さえれば大丈夫 胸部CTの基礎 腫瘤性病変のABC 肺癌

    奥泉美奈, 古泉直也, 石川浩志, 森田哲郎, 笹井啓資, 木原好則

    臨床画像   20 ( 4 )   S82 - S91   2004

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  • [High-resolution CT findings of pulmonary atypical adenomatous hyperplasia of 5 mm or less in diameter].

    Hiroyuki Ishikawa, Naoya Koizumi, Makoto Naito, Hajime Umezu, Tetsurou Morita, Takeo Nemoto, Tomoo Saito, Mina Okuizumi, Keisuke Sasai

    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica   63 ( 6 )   311 - 5   2003.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: To clarify the high-resolution CT(HRCT) findings of pulmonary atypical adenomatous hyperplasia (AAH) of 5 mm or less in diameter. MATERIALS AND METHODS: We evaluated the HRCT findings of 43 histopathologically confirmed AAH of 5 mm or less in diameter in 7 patients who underwent lobectomy for pulmonary adenocarcinoma. For comparison, we also examined the HRCT findings of 13 bronchioloalveolar carcinomas (BAC) of the same size from these patients. RESULTS: We identified 36 of 43 AAH and all 13 BAC on HRCT performed with multidetector-row CT. Thirty-five AAH and 11 BAC showed ground-glass opacity without any high-attenuation component. Margins of 20 AAH were well defined, and 16 were ill defined. In BAC, 11 lesions demonstrated well-defined margins, with only 2 showing ill-defined margins. CONCLUSION: Most AAH lesions of 5 mm or less in diameter are identified as ground-glass opacity on HRCT. Detection of minute ground-glass opacity is important in locating AAH on HRCT.

    PubMed

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  • High-resolution CT Findings of Pulmonary Atypical Adenomatous Hyperplasia of 5mm or Less in Diameter Reviewed

    Sasai Keisuke, Okuizumi Mina, Saito Tomoo, Nemoto Takeo, Morita Tetsurou, Umezu Hajime, Naito Makoto, Koizumi Naoya, Ishikawa Hiroyuki

    63 ( 6 )   311 - 315   2003

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    Authorship:Lead author   Language:Japanese  

    CiNii Article

    CiNii Books

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  • Microcystic variant of localized malignant mesothelioma accompanying an adenomatoid tumor-like lesion Reviewed

    Hajime Umezu, Kazuhisa Kuwata, Yusuke Ebe, Takashi Yamamoto, Makoto Naito, Yasushi Yamato, Takaaki Ishiyama, Masanori Tsuchida, Mina Okuizumi, Hiroshi Ishikawa, Naoya Koizumi

    Pathology International   52 ( 5-6 )   416 - 422   2002.5

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1046/j.1440-1827.2002.01357.x

    CiNii Article

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  • 限局性肺疾患 肺腫瘍 肺腺がん

    古泉直也, 森田哲郎, 石川浩志, 根本健夫

    日本胸部臨床   61 ( 11 )   S66 - S73   2002

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  • Pathologic/High-resolution CT Correlation of Focal Lung Lesions 5mm or Less in Diameter: Detection and identification by multidetector-row CT Reviewed

    ISHIKAWA Hiroyuki

    Nippon Acta Radiologica   62 ( 8 )   415 - 422   2002

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    Authorship:Lead author   Language:Japanese  

    CiNii Article

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    Other Link: http://search.jamas.or.jp/link/ui/2003026955

  • 小さい肺腺癌の画像と病理

    古泉直也, 森田哲郎, 酒井邦夫, 奥泉美奈, 木原好則, 石川浩志

    画像診断   21 ( 7 )   359 - 365   2001

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  • DPBの周辺疾患 マクロライド治療が無効でDPBとの鑑別を要した濾胞性細気管支炎の1例

    中嶋治彦, 石川浩志, 成田淳一, 寺田正樹, 横田樹也, 原口通比古, 斎藤泰晴, 丸山倫夫

    Therapeutic Research   21 ( 8 )   1882 - 1884   2000

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  • CT画像(GGO・FGGA)と病理診断

    古泉直也, 奥泉美奈, 酒井邦夫, 木原好則, 森田哲郎, 石川浩志

    肺癌の臨床   3 ( 4 )   359 - 365   2000

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  • 肺野末梢小型陰影の鑑別のポイントと診断のコツ-CT所見とCTガイド経皮肺生検-

    古泉直也, 森田哲郎, 酒井邦夫, 斎藤友雄, 木原好則, 奥泉美奈, 楚山真樹, 石川浩志, 江村巌

    Medical Practice   16 ( 4 )   597 - 600   1999

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  • 80歳以上の高齢者食道癌に対する放射線治療 Reviewed

    石川浩志, 斎藤眞理, 植松孝悦, 清水克英, 小林晋一

    臨床放射線   44 ( 7 )   823 - 828   1999

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  • 再発食道癌に対する腔内照射腔内加温同時併用治療

    斎藤眞理, 笹本龍太, 植松孝悦, 石川浩志

    臨床放射線   43 ( 8 )   953 - 957   1998

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  • Torsades de pointes及び交互性QT延長に対してメキシレチンが有効であったQT延長症候群の1例 Reviewed

    石川浩志, 広瀬保夫, 小田弘隆, 庭野慎一, 池主雅臣, 相澤義房, 樋熊紀雄

    心臓   30 ( 5 )   302 - 308   1998

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  • 早期肺癌のHRCT所見

    古泉直也, 斎藤友雄, 酒井邦夫, 森田哲郎, 奥泉美奈, 石川浩志, 海津元樹, 石川和宏

    臨床画像   14 ( 3 )   296 - 306   1998

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MISC

Presentations

  • 肺癌のCT診断 基本とピットフォール Invited

    石川浩志

    第34回胸部放射線研究会(河野通雄 記念講演2) 

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    Event date: 2020.10 - 2020.11

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  • Progression of Non-resected Pure Ground-Glass Nodules in the Cases of Resected Multiple Lung Adenocarcinomas

    Ishikawa H, Yamazaki M, Kunii R, Yoshimura N, Aoyama H

    98th RSNA 

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    Event date: 2012.11

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  • Small intrapulmonary lymph node: HRCT-pathologic correlation

    Ishikawa H, Koizumi N, Morita T, Tani Y, Umezu H, Sasai K

    90th RSNA 

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    Event date: 2004.11 - 2004.12

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  • Multidetector-row CTによる微小肺病変の高分解能CTと病理組織の対比 Invited

    石川浩志

    第11回胸部CT検診研究会 

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    Event date: 2004.2

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  • A prospective radiologic-pathologic study of minute lung opacities (5mm or less in diameter) on multidetector-row high-resolution CT of whole lung lobe

    Ishikawa H, Koizumi N, Morita T, Tani Y, Naito M, Sasai K

    89th RSNA 

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    Event date: 2003.11 - 2003.12

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  • 肺癌の画像診断 ~25年を振り返る~ Invited

    石川浩志

    新潟県診療放射線技師会 創立75周年記念行事  2021.5 

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  • CTの進歩と肺癌画像診断 Invited

    石川浩志

    第755回 新潟医学会例会  2021.5 

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  • 胸部画像診断の実際 Invited

    石川浩志

    新潟大学皮膚科特別セミナー  2021.1 

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  • すりガラス影に注目する!腫瘍性疾患 Invited

    石川浩志

    第34回JCRミッドウィンターセミナー  2021.1 

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  • 症例でみる胸部X線のピットフォールと偽病変-画像処理と読影環境の進歩を交えて- Invited

    石川浩志

    第131回県央呼吸器研究会  2019.5 

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  • 病変と紛らわしい胸部X線所見について Invited

    石川浩志

    平成30年度胸部X線フィルム読影医師勉強会・新潟市医師会肺がん診断研修会  2018.11 

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  • 低線量肺がんCT検診での読影と経過観察 Invited

    石川浩志

    第15回肺がんCT検診認定医師更新講習会 兼 認定医師新規認定講習会  2018.8 

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  • CT発見肺結節の取り扱いに関する最近の動向 Invited

    石川浩志

    第51回新潟チェストカンファランス総会  2018.7 

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  • 口腔腫瘍に関連する呼吸器系の画像診断 Invited

    石川浩志

    日本口腔腫瘍学会 第7回教育研修会  2018.1 

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  • 肺癌の画像診断 -単純写真を中心に- Invited

    石川浩志

    平成27年度新潟市医師会肺がん診断研修会  2015.11 

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  • 肺癌の画像診断-最近の話題から- Invited

    石川浩志

    第37回 旧三市中蒲呼吸器研究会 第9回特別講演会  2015.7 

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  • 胸部画像診断の実際-肺癌を中心に- Invited

    石川浩志

    新潟県診療放射線技師会平成25年度下越地区会  2014.2 

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  • 末梢型肺がんの画像所見-CTからCRへ- Invited

    石川浩志

    新潟市医師会肺がん診断研修会講習会  2013.10 

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  • 微小肺病変のCT診断 ~病理との対比、経時変化を中心に Invited

    石川浩志

    第14回順天堂大学肺癌カンファレンス  2011.10 

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  • 診てみよう胸部画像 Invited

    石川浩志

    第7回 Niigata Youth Assembly for Nephrology  2011.9 

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  • 胸部画像診断のコツ Invited

    石川浩志

    日本呼吸器学会主催第1回新潟呼吸器道場  2011.5 

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  • 小型肺結節のHRCT診断 Invited

    石川浩志

    第28回新潟県放射線科医会総会  2010.10 

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  • GGOと肺内リンパ節らしさと経時変化に着目した小病変 (5-6mm以下)の鑑別法 Invited

    石川浩志

    日本CT検診学会主催第12回読影セミナー  2008.7 

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  • MDCTによる肺微小病変 Invited

    石川浩志

    第10回東北胸部放射線研究会  2003.7 

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Research Projects

  • 放射線・病理画像テクスチャ解析を用いた肺癌の腫瘍遺伝子変異量予測モデルの開発

    Grant number:23K07103

    2023.4 - 2026.3

    System name:科学研究費助成事業

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    山崎 元彦, 石川 浩志, 大橋 瑠子, 若井 俊文, 奥田 修二郎, 島田 能史, 後藤 達哉, 土田 正則, 竹中 朋祐, 河野 幹寛

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

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  • 大腸癌の変異シグネチャーを予測するRadiogenomics解析法の確立

    Grant number:22K08794

    2022.4 - 2025.3

    System name:科学研究費助成事業

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    松本 瑛生, 宗岡 悠介, 島田 能史, 山崎 元彦, 若井 俊文, 凌 一葦, 石川 浩志, 長櫓 宏規, 田島 陽介, 須貝 美佳, 山井 大介

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    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

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  • すりガラス結節の長期経過の解明とその早期予測の可能性

    Grant number:21K07640

    2021.4 - 2024.3

    System name:科学研究費助成事業 基盤研究(C)

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    石川 浩志

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    Grant amount:\2730000 ( Direct Cost: \2100000 、 Indirect Cost:\630000 )

    すりガラス型結節は病理学的に肺腺癌の前浸潤性病変である異型腺腫様過形成や上皮内腺癌の可能性が高く、微少浸潤性腺癌、浸潤性病変へと緩徐に進行していくことが知られている。また、この病理学的な進行に対応する形で、CTでは結節の性状がすりガラス型結節から部分充実型結節、さらには充実型結節へと変化していくことが知られている。また、これらの経過を経ずに最初から進行した形での浸潤性腺癌として発症する症例も経験される。これらの肺腺癌の進行過程を踏まえ、研究代表者は研究分担者らとともに肺腺癌のCT所見に関する解説論文を発表した。本研究の主目的である10年~20年に及ぶすりガラス型結節の経過を予測するうえでCT所見と病理所見の対比は非常に重要である。その一方で、CT所見の視覚的評価には限界があることを踏まえ、本研究では、すりガラス型結節に重点を置いた定量的解析、radiomicsによる検討を今後行っていく予定である。Radiomicsは肺癌を含め、様々な画像評価において、現在も発展し続けている解析法であり、令和3年度には研究代表者は研究分担者らとともに肺腺癌のCT所見にradiomicsを応用して患者の予後や腫瘍の遺伝子変異との関連を検討し、その結果の一部を学会で報告した。これらの結果は肺腺癌のより早い段階にあることが推定されるすりガラス型結節の画像評価を行う上でも重要な示唆を与えてくれる。今後はすりガラス型結節に関してradiomicsで得られる特徴量および特徴量の変化と病理所見の関連性や、進行の可能性や進行速度に関する早期解明の可能性について明らかにしていく予定である。また、対象には腺癌以外のすりガラス型結節も加え、それらの鑑別診断の可能性について併せて検討することを予定している。

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  • 児童虐待に対応するための小児死後CTの至適条件、死後変化、診断の標準化の検討

    Grant number:20H01654

    2020.4 - 2025.3

    System name:科学研究費助成事業 基盤研究(B)

    Research category:基盤研究(B)

    Awarding organization:日本学術振興会

    高橋 直也, 高塚 尚和, 舟山 一寿, 成田 啓廣, 石川 浩志, 堀井 陽祐, 的場 光太郎

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    Grant amount:\9360000 ( Direct Cost: \7200000 、 Indirect Cost:\2160000 )

    1)小児死後CTの至適条件の検討について。新生児の体格とX線吸収値を模した新生児ファントムを新潟大学医学部法医学教室の16列DualエネルギーMDCTで撮像して得られたCT画像の画質を検討した。CTでは管電流をあげると良好な画像が得られる。被曝の影響を考慮する必要がない遺体の場合、臨床で用いられない高い管電流を使用することが可能であるが、必要以上の管電流を使用すると、機器の負担が増える。複数の管電流を用いて得られた頭部CT画像に、計算ソフトウェアを用いて作成した仮想模擬病変を挿入し、病変の検出能を検討した。経験豊富な2名の放射線科医が、仮想模擬病変が挿入されたCT画像を観察し、この病変が検出できるかどうかを判断し、微細病変の検出に必要な最低限の撮像条件を明らかにした。今後は、小児ファントムを用いて、同様の撮像実験、病変検出能の検討を行い、体格の異なる小児におけるCTの至適条件を検討する予定である。
    2)小児死後CTの画像収集について。2-1)2021年度に新潟大学法医学教室で死後CT検査が行われた小児は4例であった。このうち2例で解剖が行われ、体内の状態と死因についての結果が得られた。解剖が行われた症例については死後CTの画像所見と解剖における実際の所見を比較検討が可能であった。今後は、症例を蓄積し、死後画像所見における死因究明、死後変化について、さらなる検討を行う。2-2)新潟大学放射線医学教室の協力のもと、関連病院において小児死後CT画像の症例の提供を依頼した。各病院の倫理審査委員会で審議を行っていただき、症例提供の手続きを行った。関連病院から、2020年4月から2025年3月までの症例を提供していただき、死後CT所見における死後変化や死因究明の検討を行う。

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  • Establishment of CT diagnosis of small adenocarcinoma of the lung based on quantitative image analysis

    Grant number:17K10352

    2017.4 - 2020.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Ishikawa Hiroyuki

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    Grant amount:\2600000 ( Direct Cost: \2000000 、 Indirect Cost:\600000 )

    Adenocarcinoma in situ and minimally invasive adenocarcinoma were accurately differentiated from invasive adenocarcinoma of the lung using quantitative CT image analysis, which appeared as ground-glass opacity at high-resolution CT.
    Reproducibility of quantitative analysis was maintained regardless of experience of CT image interpretation. Quantitative image analysis and automatic feature extraction using artificial intelligence can stratify the postoperative prognosis and may have equal or greater prognostic accuracy than conventional features evaluated by experienced thoracic radiologists.

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  • Study of method to estimate histopathologic diagnosis of ultra-small pulmonary nodule by multi-slice CT

    Grant number:19790859

    2007 - 2008

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Research category:Grant-in-Aid for Young Scientists (B)

    Awarding organization:Japan Society for the Promotion of Science

    ISHIKAWA Hiroyuki

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    Grant amount:\2210000 ( Direct Cost: \2000000 、 Indirect Cost:\210000 )

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Teaching Experience (researchmap)

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Teaching Experience

  • 医学序説 I

    2022
    Institution name:新潟大学

  • 医学物理学入門

    2022
    Institution name:新潟大学

  • 臨床医学講義(集中)

    2021
    Institution name:新潟大学

  • 臓器別講義・演習III

    2021
    Institution name:新潟大学

  • 医学序説 II

    2021
    Institution name:新潟大学