Updated on 2022/12/05


Brain Research Institute Center for Integrated Human Brain Science Assistant Professor
Assistant Professor
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  • 博士(工学) ( 2002.3   新潟大学 )

Research Interests

  • MRI

  • PET

  • 生体信号処理

Research Areas

  • Life Science / Neuroscience-general

  • Life Science / Biomedical engineering

  • Life Science / Function of nervous system

Research History

  • Niigata University   Center for Integrated Human Brain Science, Brain Research Institute   Assistant Professor


  • Niigata University   Brain Research Institute Center for Integrated Human Brain Science   Specially Appointed Assistant Professor

    2018.10 - 2021.3

  • Niigata University   Institute for Research Promotion Center for Transdisciplinary Research   Assistant Professor

    2011.4 - 2018.9

  • Niigata University   Center for Transdisciplinary Research   Assistant Professor

    2004.4 - 2011.3

  • Niigata University   Brain Research Institute Center for Integrated Human Brain Science   Researcher

    2002.4 - 2004.3



  • Skull diploë is rich in aquaporin-4 Reviewed

    Suzuki Y, Kitaura H, Nakamura Y, Kakita A, Huber VJ, Capozzoli N, Kwee IL, Nakada T

    Heliyon   6 ( 1 )   e03259 - e03259   2020.1

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.heliyon.2020.e03259



  • Aquaporin Positron Emission Tomography Differentiates Between Grade III and IV Human Astrocytoma Reviewed

    Suzuki Y, Nakamura Y, Yamada K, Kurabe S, Okamoto K, Aoki H, Kitaura H, Kakita A, Fujii Y, Huber VJ, Igarashi H, Kwee IL, Nakada T

    Neurosurgery   82 ( 6 )   842 - 846   2018.6

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    Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed in malignant astrocytomas, and a positive correlation is observed between their expression levels and histological tumor grade.

    To examine the utility of aquaporin positron emission tomography (PET) for differentiating between astrocytoma grade III and grade IV using the AQP radioligand [11C]TGN-020.

    Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10 healthy volunteers underwent [11C]TGN-020 aquaporin PET imaging. Surgical tissues of astrocytoma patients were examined for histopathological grading using the WHO classification standard and expression of AQP1 and AQP4 immunohistochemically.

    Mean standardized uptake values of astrocytoma grade III and IV (0.51 ± 0.11 vs 1.50 ± 0.44, respectively) were higher than normal white matter (0.17 ± 0.02, P &amp;lt; .001) for both tumor grades. Importantly, mean standardized uptake values of astrocytoma grade IV were significantly higher than grade III (P &amp;lt; .01).

    Our study demonstrated that [11C]TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as a noninvasive diagnostic tool would lead to advancements in the management of these malignant brain tumors.


    DOI: 10.1093/neuros/nyx314



  • Reduced CSF Water Influx in Alzheimer’s Disease Supporting the β-Amyloid Clearance Hypothesis Reviewed

    Suzuki Y, Nakamura Y, Yamada K, Igarashi H, Kasuga K, Yokoyama Y, Ikeuchi T, Nishizawa M, Kwee IL, Nakada T

    PLOS ONE   10 ( 5 )   e0123708 - e0123708   2015.5

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    Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science (PLoS)  

    DOI: 10.1371/journal.pone.0123708



  • Aquaporin-4 positron emission tomography imaging of the human brain: first report. Reviewed International journal

    Suzuki Y, Nakamura Y, Yamada K, Huber VJ, Tsujita M, Nakada T

    Journal of neuroimaging : official journal of the American Society of Neuroimaging   23 ( 2 )   219 - 23   2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND AND PURPOSE: Aquaporin 4 (AQP-4) is the most abundant aquaporin isoform in the brain. Alterations in its expression and distribution have been correlated with the progression of several clinical disorders; however, the specific roles of AQP-4 in those disorders are not well understood. Visualizing AQP-4 in vivo is expected to provide fresh insights into its roles in disease pathology, as well as aiding the clinical assessment of those disorders. METHODS: We developed a 11C-labeled analogue of the AQP-4 ligand TGN-020 (2-nicotinamido-1,3,4-thiadiazole) suitable for in vivo positron emission tomography (PET) imaging. RESULTS: In the present study, we report the first PET images of AQP-4 in the human brain. The results unequivocally demonstrated a specific distribution pattern for AQP-4 within the brain, namely, the subpial and perivascular endfeet of astrocytes. The choroid plexus, where both AQP-4 and AQP-1 are expressed, also showed substantial uptake of the ligand. CONCLUSIONS: Based on these initial results, we believe [11C]TGN-020 PET will be valuable in determining the role of AQP-4 in disease progression, and for the clinical assessment of water homeostasis under various settings.

    DOI: 10.1111/j.1552-6569.2012.00704.x



  • Development of a Novel Ligand, [11C]TGN-020, for Aquaporin 4 Positron Emission Tomography Imaging Reviewed

    Nakamura Y, Suzuki Y, Tsujita M, Huber VJ, Yamada K, Nakada T

    ACS Chemical Neuroscience   2 ( 10 )   568 - 571   2011.10

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/cn2000525



  • The effect of 1/f fluctuation in inter-stimulus intervals on auditory evoked mismatch field Reviewed

    Harada N, Masuda T, Endo H, Nakamura Y, Takeda T, Tonoike M

    NEUROSCIENCE LETTERS   379 ( 3 )   223 - 228   2005.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER IRELAND LTD  

    This study focused on the effect of regularity of environmental stimuli on the informational order extracting function of human brain. The regularity of environmental stimuli can be described with the exponent n of the fluctuation 1/f".
    We studied the effect of the exponent of the fluctuation in the inter-stimulus interval (ISI) on the elicitation of auditory evoked mismatch fields (MMF) with two sounds with alternating frequency. ISI times were given by three types of fluctuation, 1/f(0), 1/f(1), 1/f(2), and with a fixed interval (1/f(&INFIN;)). The root mean square (RMS) value of the MMF increased significantly (F(3/9) = 4.95, p = 0.027) with increases in the exponent of the fluctuation. Increments in the regularity of the fluctuation provoked enhancement of the MMF, which reflected the production of a memory trace, based on the anticipation of the stimulus timing. The gradient of the curve, indicating the ratio of increments between the MMF and the exponent of fluctuation, can express a subject's capability to extract regularity from fluctuating stimuli. &COPY; 2005 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.neulet.2005.01.012

    Web of Science



  • Influence of motor unit firing patterns on evaluation of muscle activities by Karhunen-Loève expansion Reviewed

    Nakamura Y, Kaneko H, Kiryu T, Suzuki SS, Saitoh Y

    Systems and Computers in Japan   34 ( 12 )   45 - 55   2003.11

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/scj.10326


  • Multivariate analysis of multichannel surface myoelectric signals to determine muscular fatigue. Reviewed International journal

    Nakamura Y, Kiryu T, Saitoh Y

    Methods of information in medicine   36 ( 4-5 )   302 - 5   1997.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    Multivariate analysis would be effective in finding the functional change from several variables obtained from multivariate biological signals. We applied this idea to the discrimination of sustained fatiguing contraction from negative ramp contraction. The time-series of eigenvalues were obtained from multidimensional biological variables by the Karhunen-Loève expansion. The results showed that, the first and second eigenvalues came close to each other during fatiguing contraction, whereas only the first eigenvalue was dominant during negative ramp contraction. Moreover, the factor loadings showed considerable difference between fatiguing contraction and negative ramp contraction. As a result, the muscular-fatigue-related functional change could be represented clearly by the time-series of proportions and factor loadings.



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