研究者詳細 - 中村　ゆきみ

写真a

ナカムラ　ユキミ

中村　ゆきみ

NAKAMURA Yukimi

所属

脳研究所統合脳機能研究センター助教

外部リンク

学位

博士(工学) （ 2002年3月新潟大学）

研究キーワード

MRI
PET
生体信号処理

研究分野

ライフサイエンス / 神経科学一般
ライフサイエンス / 生体医工学
ライフサイエンス / 神経機能学

経歴

新潟大学脳研究所統合脳機能研究センター助教

2021年4月 - 現在
新潟大学脳研究所　統合脳機能研究センター特任助教

2018年10月 - 2021年3月
新潟大学研究推進機構　超域学術院助教

2011年4月 - 2018年9月
新潟大学超域研究機構助教

2004年4月 - 2011年3月
新潟大学脳研究所　統合脳機能研究センター研究員

2002年4月 - 2004年3月

論文

Skull diploë is rich in aquaporin-4 査読

Suzuki Y, Kitaura H, Nakamura Y, Kakita A, Huber VJ, Capozzoli N, Kwee IL, Nakada T

Heliyon 6 ( 1 ) e03259 - e03259 2020年1月

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掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

DOI： 10.1016/j.heliyon.2020.e03259

PubMed

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Aquaporin Positron Emission Tomography Differentiates Between Grade III and IV Human Astrocytoma 査読

Suzuki Y, Nakamura Y, Yamada K, Kurabe S, Okamoto K, Aoki H, Kitaura H, Kakita A, Fujii Y, Huber VJ, Igarashi H, Kwee IL, Nakada T

Neurosurgery 82 ( 6 ) 842 - 846 2018年6月

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掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

<title>Abstract</title>
<sec>
<title>BACKGROUND</title>
Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed in malignant astrocytomas, and a positive correlation is observed between their expression levels and histological tumor grade.

</sec>
<sec>
<title>OBJECTIVE</title>
To examine the utility of aquaporin positron emission tomography (PET) for differentiating between astrocytoma grade III and grade IV using the AQP radioligand [11C]TGN-020.

</sec>
<sec>
<title>METHODS</title>
Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10 healthy volunteers underwent [11C]TGN-020 aquaporin PET imaging. Surgical tissues of astrocytoma patients were examined for histopathological grading using the WHO classification standard and expression of AQP1 and AQP4 immunohistochemically.

</sec>
<sec>
<title>RESULTS</title>
Mean standardized uptake values of astrocytoma grade III and IV (0.51 ± 0.11 vs 1.50 ± 0.44, respectively) were higher than normal white matter (0.17 ± 0.02, P &lt; .001) for both tumor grades. Importantly, mean standardized uptake values of astrocytoma grade IV were significantly higher than grade III (P &lt; .01).

</sec>
<sec>
<title>CONCLUSION</title>
Our study demonstrated that [11C]TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as a noninvasive diagnostic tool would lead to advancements in the management of these malignant brain tumors.

</sec>

DOI： 10.1093/neuros/nyx314

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Reduced CSF Water Influx in Alzheimer’s Disease Supporting the β-Amyloid Clearance Hypothesis 査読

Suzuki Y, Nakamura Y, Yamada K, Igarashi H, Kasuga K, Yokoyama Y, Ikeuchi T, Nishizawa M, Kwee IL, Nakada T

PLOS ONE 10 ( 5 ) e0123708 - e0123708 2015年5月

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掲載種別：研究論文（学術雑誌）出版者・発行元：Public Library of Science (PLoS)

DOI： 10.1371/journal.pone.0123708

PubMed

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Aquaporin-4 positron emission tomography imaging of the human brain: first report. 査読国際誌

Suzuki Y, Nakamura Y, Yamada K, Huber VJ, Tsujita M, Nakada T

Journal of neuroimaging : official journal of the American Society of Neuroimaging 23 ( 2 ) 219 - 23 2013年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND AND PURPOSE: Aquaporin 4 (AQP-4) is the most abundant aquaporin isoform in the brain. Alterations in its expression and distribution have been correlated with the progression of several clinical disorders; however, the specific roles of AQP-4 in those disorders are not well understood. Visualizing AQP-4 in vivo is expected to provide fresh insights into its roles in disease pathology, as well as aiding the clinical assessment of those disorders. METHODS: We developed a 11C-labeled analogue of the AQP-4 ligand TGN-020 (2-nicotinamido-1,3,4-thiadiazole) suitable for in vivo positron emission tomography (PET) imaging. RESULTS: In the present study, we report the first PET images of AQP-4 in the human brain. The results unequivocally demonstrated a specific distribution pattern for AQP-4 within the brain, namely, the subpial and perivascular endfeet of astrocytes. The choroid plexus, where both AQP-4 and AQP-1 are expressed, also showed substantial uptake of the ligand. CONCLUSIONS: Based on these initial results, we believe [11C]TGN-020 PET will be valuable in determining the role of AQP-4 in disease progression, and for the clinical assessment of water homeostasis under various settings.

DOI： 10.1111/j.1552-6569.2012.00704.x

PubMed

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Development of a Novel Ligand, [11C]TGN-020, for Aquaporin 4 Positron Emission Tomography Imaging 査読

Nakamura Y, Suzuki Y, Tsujita M, Huber VJ, Yamada K, Nakada T

ACS Chemical Neuroscience 2 ( 10 ) 568 - 571 2011年10月

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掲載種別：研究論文（学術雑誌）出版者・発行元：American Chemical Society (ACS)

DOI： 10.1021/cn2000525

PubMed

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The effect of 1/f fluctuation in inter-stimulus intervals on auditory evoked mismatch field 査読

Harada N, Masuda T, Endo H, Nakamura Y, Takeda T, Tonoike M

NEUROSCIENCE LETTERS 379 ( 3 ) 223 - 228 2005年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER IRELAND LTD

This study focused on the effect of regularity of environmental stimuli on the informational order extracting function of human brain. The regularity of environmental stimuli can be described with the exponent n of the fluctuation 1/f".
We studied the effect of the exponent of the fluctuation in the inter-stimulus interval (ISI) on the elicitation of auditory evoked mismatch fields (MMF) with two sounds with alternating frequency. ISI times were given by three types of fluctuation, 1/f(0), 1/f(1), 1/f(2), and with a fixed interval (1/f(&INFIN;)). The root mean square (RMS) value of the MMF increased significantly (F(3/9) = 4.95, p = 0.027) with increases in the exponent of the fluctuation. Increments in the regularity of the fluctuation provoked enhancement of the MMF, which reflected the production of a memory trace, based on the anticipation of the stimulus timing. The gradient of the curve, indicating the ratio of increments between the MMF and the exponent of fluctuation, can express a subject's capability to extract regularity from fluctuating stimuli. &COPY; 2005 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.neulet.2005.01.012

Web of Science

PubMed

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Influence of motor unit firing patterns on evaluation of muscle activities by Karhunen-Loève expansion 査読

Nakamura Y, Kaneko H, Kiryu T, Suzuki SS, Saitoh Y

Systems and Computers in Japan 34 ( 12 ) 45 - 55 2003年11月

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掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

DOI： 10.1002/scj.10326

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Multivariate analysis of multichannel surface myoelectric signals to determine muscular fatigue. 査読国際誌

Nakamura Y, Kiryu T, Saitoh Y

Methods of information in medicine 36 ( 4-5 ) 302 - 5 1997年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Multivariate analysis would be effective in finding the functional change from several variables obtained from multivariate biological signals. We applied this idea to the discrimination of sustained fatiguing contraction from negative ramp contraction. The time-series of eigenvalues were obtained from multidimensional biological variables by the Karhunen-Loève expansion. The results showed that, the first and second eigenvalues came close to each other during fatiguing contraction, whereas only the first eigenvalue was dominant during negative ramp contraction. Moreover, the factor loadings showed considerable difference between fatiguing contraction and negative ramp contraction. As a result, the muscular-fatigue-related functional change could be represented clearly by the time-series of proportions and factor loadings.

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