担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1039/D1RA08706A

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Royal Society of Chemistry (RSC)  

<p>Synthesis of optically active 2-substituted azetidine-2-carbonitriles by LDA-promoted diastereoselective α-alkylation of borane <italic>N</italic>-((<italic>S</italic>)-1-arylethyl)azetidine-2-carbonitrile complexes was demonstrated.</p>

DOI： 10.1039/d1ra04585g

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担当区分：筆頭著者,　責任著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：American Chemical Society (ACS)  

DOI： 10.1021/acs.joc.0c01047

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

DOI： 10.1016/j.tet.2020.131064

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/ejoc.201801448

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.tet.2018.12.058

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Royal Society of Chemistry ({RSC})  

DOI： 10.1039/c8ob01395k

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Royal Society of Chemistry ({RSC})  

DOI： 10.1039/c8ob01091a

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1039/c7ob01391d

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その他リンク： http://orcid.org/0000-0002-0309-9507

担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley-Blackwell  

DOI： 10.1002/ejoc.201600611

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担当区分：筆頭著者,　責任著者   記述言語：英語   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

An overview of the utility of base-induced Stevens, Sommelet-Hauser, and related sigmatropic rearrangements of N-heterocyclic ammonium salts into various types of N-heterocycles reported after 1970 will be described. The synthetic transformations are classified as N-heterocyclic ring-substitution, ring-enlargement, and ring-contraction.

DOI： 10.3987/REV-16-837

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：AMER CHEMICAL SOC  

Oxidative ring-opening reactions of benzene-fused bicyclic cydopropyl silyl ethers, promoted by copper(II) tetrafluoroborate, were investigated. The regioselectivity of cyclopropane ring-opening as well as product distributions were found to be highly dependent on the nature of the solvent. In alcohols, dimeric substances arising from external bond cleavage are major products. Radical rearrangement products are also formed in solvents such as ether and ethyl acetate. On the contrary, nucleophile addition to carbocation intermediates, generated by internal bond cleavage, occurs mainly in reactions taking place in acetonitrile. It is proposed that the observed solvent effects that govern the reaction pathways followed are a consequence of varying solvation of copper intermediates, which governs their reactivity and redox properties. In addition, the influence of counteranions of the copper salts, organonitriles, cyclic dienes, and substrate structures on the pathways followed in these reactions was also examined.

DOI： 10.1021/acs.joc.5b02827

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その他リンク： http://orcid.org/0000-0002-0309-9507

担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

The regioselective synthesis of secondary 1,3-dienamides 3 (1-N-acylamino-1,3-dienes) is successfully demonstrated by regiospecific base -promoted 1,4 -elimination of (Z)- or (E)-N,N-di-Boc-4-methoxy-2-buten-1 -ylamine 1 followed by mono-Boc elimination in situ. (C) 2015 Elsevier Ltd. All rights reserved,

DOI： 10.1016/j.tet.2015.11.065

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ROYAL SOC CHEMISTRY  

[5]Catenanes were synthesized by olefin metathesis dimerization. The reaction of pseudorotaxanes, which were derived from a [2]catenane and one equivalent of an ammonium salt bearing two terminal olefins in dichloromethane, with a catalytic amount of Grubbs catalyst afforded linear [5]catenanes in 12% yield. Intermolecular and intramolecular olefin metathesis reactions were controlled by the length of the alkyl chain of the ammonium salts.

DOI： 10.1039/c5cc07562a

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その他リンク： http://orcid.org/0000-0002-0309-9507

担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1039/c6cc04626f

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その他リンク： http://orcid.org/0000-0002-0309-9507

担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：GEORG THIEME VERLAG KG  

The copper-catalyzed regiospecific and 1,2-regioselective cyclopropanation of (1Z)-1-amino- and (1Z)-1-oxy-1,3-butadienyl derivatives, which could be prepared by Z-stereoselective 1,4-elimination with a-aryl diazoesters was successfully demonstrated. This successful regiospecific protocol enabled the preparation of the corresponding 1-amino- and 1-oxy-2-vinylcyclopropane derivatives as almost single stereoisomers.

DOI： 10.1055/s-0034-1380426

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/tcr.201500009

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その他リンク： http://orcid.org/0000-0002-0309-9507

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

Photoinduced electron transfer (PET) reactions promoted by 2-aryl substituted 1,3-dimethylbenzimidazolines (Ar-DMBIH) were investigated. Excited states of Ar-DMBIH, formed by irradiation using light above 360 initiate PET reductions of various organic substrates, including transformations of epoxy ketones to aldols, free radical rearrangements such as the Dowd-Beckwith ring-expansion and 5-exo hexenyl cyclization, deprotection of N-sulfonyl-indols, and allylation of acyl formates. In these processes, Ar-DMBIH possessing 1-naphthyl, 2-naphthyl, 1-pyrenyl and 9-anthryl substituents formally act as two electron and one proton donors while the hydroxynaphthyl substituted derivative serves as a two electron and two proton donor. On the basis of the results of absorption spectroscopy studies, cyclic voltammetry and DFT calculation, a mechanistic sequence for these reduction reactions is proposed that involves initial photoexcitation of the aryl chromophore of the Ar-DMBIH followed by single electron transfer (SET) to the organic substrate to generate the radical cation of benzimidazoline and the radical anion of the substrate. (C) 2015 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tet.2015.06.071

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1021/jo5025249

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その他リンク： http://orcid.org/0000-0002-0309-9507

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

The base-promoted 1,4-elimination reaction of N-Boc-1-amino-4-methoxy-2-alkene 1 is shown to proceed with perfect stereoselectivity to afford the corresponding N-Boc-1-amino-1,3-diene 2 in good yields. The reaction is highly stereospecific. The substrate E-1 gave 1Z-2 by the 'Syn-Effect' and Z-1 gave 1E-2 via formation of a chelated intermediate. Our method is widely applicable to the preparation of various types of N-Boc-1-amino-1,3-dienes 2. (C) 2014 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tet.2014.12.039

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/j.tetlet.2014.03.115

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/j.tet.2014.02.078

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担当区分：筆頭著者,　責任著者   記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.5059/yukigoseikyokaishi.72.418

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ROYAL SOC CHEMISTRY  

The base-induced asymmetric [2,3] Stevens rearrangement of N-cinnamyl tetraalkylammonium ylides derived from L-alanine amides proceeds via a double axially chiral intermediate to afford the corresponding alpha-substituted alanine derivatives with high enantio-and diastereoselectivities.

DOI： 10.1039/c4cc02536a

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/j.tetlet.2013.10.028

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BEILSTEIN-INSTITUT  

Copper(II)-salt-promoted oxidative ring-opening reactions of bicyclic cyclopropanol derivatives were investigated. The regioselectivities of these processes were found to be influenced by the structure of cyclopropanols as well as the counter anion of the copper(II) salts. A mechanism involving rearrangement reactions of radical intermediates and their competitive trapping by copper ions is proposed.

DOI： 10.3762/bjoc.9.156

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その他リンク： http://orcid.org/0000-0002-0309-9507

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：AMER CHEMICAL SOC  

The syntheses of [2]- and [3]catenanes by olefin metathesis and oxidative acetylide coupling have been studied in detail. Pseudorotaxanes that were obtained by mixing crown ether and ammonium salts containing two terminal reactive end-groups were converted to [2]- and [3]catenane. Their yields were influenced not only by the chain length of the ammonium salts but also by the concentration of the crown ether and the ammonium salts. The strain energies of [2]catenane were responsible for the formation of [2]catenane.

DOI： 10.1021/jo400239h

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その他リンク： http://orcid.org/0000-0002-0309-9507

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/j.tet.2013.01.088

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Institute of Heterocyclic Chemistry  

DOI： 10.3987/COM-12-12619

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Institute of Heterocyclic Chemistry  

DOI： 10.3987/COM-12-S(N)78

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/j.tetlet.2012.07.070

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/j.tet.2012.04.015

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

A new protecting group, 1,2-dimethoxy-4,5-dimethylene, for acyclic amino acid derivatives could be introduced by N,N-dialkylation with 1,2-bis(bromomethyl)-4,5-dimethoxybenzene (1) and removed via amine de-alkylation with acyl chlorides. The method can be used with base-induced [2,3] and [1,2] Stevens rearrangement products. (C) 2012 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2012.01.013

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Royal Society of Chemistry ({RSC})  

DOI： 10.1039/c1ob06074k

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/j.tetlet.2011.02.040

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

The intermolecular aromatic substitution of N,N-disubstituted anilines with diazo esters is achieved under mild conditions in the presence of a catalytic amount of copper(II) triflate (up to 89% yield). The scope and limitations regarding substrates, diazo esters, and ligands in this reaction are described.

DOI： 10.1002/ejoc.201001083

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

Aza-Prins cyclization reaction of N-tosyl-3-butenylamine with aliphatic and aromatic aldehydes was performed using a combination of FeCl3 and 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF(6)) or 1-butyl-3-methylimidazolium tetrachloroferrate (BmimFeCl(4)) in benzotrifluoride (BTF). The desired N-tosyl-4-chloro-2-substituted piperidines were obtained from aliphatic aldehydes in comparable yields to those for the previously reported reactions in which FeCl3 was used in CH2Cl2. On the other hand, significant progress for the piperidine synthesis from aromatic aldehydes has been achieved, particularly when BmimFeCl(4) was used with FeCl3 in BTF. (C) 2010 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2010.10.018

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/j.tet.2010.09.125

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

The resolution of N-chiral, amino acid-derived quaternary ammonium salts is demonstrated by using chiral BINOL as a complexing agent. Determination of the enantiopurities and absolute configurations of the resolved N-chiral tetraalkylammonium salts are described. The [1,2] Stevens rearrangement of N-chiral ammonium salts is shown to proceed with N-to-C chirality transmission to afford optically active 3-substituted morpholin-2-one derivatives. (C) 2009 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetasy.2009.10.025

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Royal Society of Chemistry ({RSC})  

DOI： 10.1039/b811162f

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1039/b806492j

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その他リンク： http://orcid.org/0000-0002-0309-9507

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/j.tetlet.2007.09.049

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

The 1,4-elimination reaction of 1-amino-4-methoxy-(2Z) -alkenes is shown to proceed with high (1E,3E)-stereoselectivities to afford the corresponding 4-substituted-1-amino-1,3-dienes in good yield. The scope and stereochemical features of the synthetic method are described. (c) 2007 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2007.06.140

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/j.tetlet.2007.04.078

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley-Blackwell  

DOI： 10.1002/anie.200703832

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：AMER CHEMICAL SOC  

The Ferrier reaction of O-1,3-dienyl acetals promoted by organoaluminum complexes such as methylaluminum bis(2,6-di-tert-butyl-4-methylphenoxide) (MAD) is shown to proceed with a high degree of regio- and stereoselectivity to afford the corresponding alpha-alkenyl-substituted beta-alkoxy aldehydes in good yields. The mechanistic origin of the high regiocontrolling ability of MAD is elucidated. This method, coupled with the easy availability of the requisite substrates, expands the synthetic scope of the Ferrier reaction.

DOI： 10.1021/ol062042j

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

The 1,4-elimination reaction of 1-allyloxy-4-methoxy-(2Z)-alkenes with n-butyllithium is shown to proceed in a marked preference to the [2,3] Wittig rearrangement to afford the allylic (1Z,M)-dienyl ethers in high stereoselectivities. The synthetic utility of this method is demonstrated by the Claisen rearrangement of the dienyl ethers thus obtained. (c) 2006 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2006.08.100

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHEMICAL SOC JAPAN  

The Stevens rearrangement of (S)-N-benzylic proline-derived ammonium salt with cesium hydroxide in 1,2-dichloroethane is shown to proceed with a high degree of the N-to-C chirality transmission to afford the alpha-substituted proline derivatives in high enantio-purities.

DOI： 10.1246/cl.2006.478

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：GEORG THIEME VERLAG KG  

Treatment of l-alkoxy-4-methoxy-(2Z)-alkenes or l-siloxy-4-methoxy-(2Z)-alkenes with n-butyllithium in diethyl ether is shown to afford the corresponding (1Z,3E)-dienyl, alkyl or silyl ethers, respectively, in high stereoselectivity via a facile 1,4-elimination. The scope and the regio- and stereochemical features of the synthetic method are described.

DOI： 10.1055/s-2006-939053

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Institute of Heterocyclic Chemistry  

DOI： 10.3987/COM-05-S(K)39

DOI： 10.3987/com-05-s(k)39

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1021/ja0459328

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その他リンク： http://orcid.org/0000-0002-0309-9507

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：AMER CHEMICAL SOC  

DOI： 10.1021/ja043898r

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その他リンク： http://orcid.org/0000-0002-0309-9507

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

Lewis acid catalyzed direct vinylogous Mannich-type reaction with a weak nucleophile dienol, generated in situ by ringopening and rearrangement of vinyloxiranes, could be demonstrated in excellent yields under mild conditions using benzylidene(4-methoxy-2-trifluoromethvl)aniline (MTMA) as an electrophile. The o-trifluoromethyl substituent can stabilize imines by a steric effect and activate by an electron-withdrawing effect. It proved to be an easily deprotectable protecting group for direct Mannich-type reactions. (C) 2004 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2004.04.165

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：NATL ACAD SCIENCES  

The asymmetric phase-transfer catalytic alkylation of peptides has been achieved by the use of designed C-2-symmetric chiral quaternary ammonium bromide 1 as catalyst. Excellent stereoselectivities were uniformly observed in the alkylation with a variety of alkyl halides and the efficiency of the transmission of stereochemical information was not affected by the side-chain structure of the preexisting amino acid residues. This method also enables an asymmetric construction of noncoded alpha,alpha-dialkyl-alpha-amino acid residues at the peptide terminal. Since this chirality can be efficiently transferred to the adjacent amino acid moiety, our approach provides a general procedure not only for the highly stereoselective terminal functionalization of peptides but also for the sequential asymmetric construction of unnatural oligopeptides, which should play a vital role in the peptide-based drug discovery process.

DOI： 10.1073/pnas.0307725101

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その他リンク： http://orcid.org/0000-0002-0309-9507

記述言語：英語   出版者・発行元：AMER CHEMICAL SOC  

A series of (2,7-disubstituted-1,8-biphenylenedioxy)bis(dimethylaluminum) (2) has been readily prepared in situ by treatment of the requisite 2,7-disubstituted-1,8-biphenylenediol (1) with Me3Al (2 equiv) in CH2Cl2 at room temperature; this primarily relies on the successful establishment of a new synthetic procedure of 1 starting from inexpensive m-anisidine. Evaluation of 2 as a bidentate organoaluminum Lewis acid has been performed by the reduction of ketonic substrates using Bu3SnH as a hydride source in comparison to the conventional monodentate Lewis acid dimethylaluminum 2,6-xylenoxide (11), uncovering the significantly high activation ability of 2 toward carbonyl. Particularly, (2,7-dimethyl-1,8-biphenylenedioxy)bis(dimethylaluminum) (2a) exerted the highest reactivity, which has also been emphasized in the Mukaiyama aldol reaction. The structure of the bidentate Lewis acid 2 was unambiguously determined by single-crystal X-ray diffraction analysis of 2g possessing a bulky 3,5-di-tert-butylphenyl substituent, revealing the rigid dimeric assembly in the solid state. The double electrophilic activation of carbonyl substrate by 2a has been supported by low-temperature C-13 NMR analysis as well as theoretical study using the Gaussian 98 program. Moreover, unique stereoselectivity has been observed in the 2a-promoted Mukaiyama Michael addition, and highly chemoselective functionalization of carbonyl compounds in the presence of their acetal counterparts has been realized using 2a. Finally, the effectiveness of 2a for the activation of ether functionality has been demonstrated in the Claisen rearrangement of allyl vinyl ethers.

DOI： 10.1021/ja030552s

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その他リンク： http://orcid.org/0000-0002-0309-9507

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：AMER CHEMICAL SOC  

The first synthetic application of 2-methyl-2-vinyloxirane as a masked dienolate has been successfully demonstrated in the direct vinylogous Mannich-type reaction with an alpha-imino ester as an electrophile. The Mannich adduct was a useful intermediate en route to cis-5-substituted pipecolinic acid ethyl ester under simple hydrogenation conditions.

DOI： 10.1021/ol036153j

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-V C H VERLAG GMBH  

DOI： 10.1002/anie.200352658

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その他リンク： http://orcid.org/0000-0002-0309-9507

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-V C H VERLAG GMBH  

DOI： 10.1002/anie.200390167

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

Chiral bis(organoaluminum) Lewis acids have been newly designed and synthetic utility of their eminent activation ability of an ether functionality has been successfully demonstrated by the application to asymmetric Claisen rearrangement of allyl vinyl ethers. (C) 2002 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S0040-4020(02)00981-X

DOI： 10.1016/s0040-4020(02)00981-x

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

A remarkable template effect in the intramolecular radical cyclization process has been observed by the successful utilization of Lewis acid receptor, aluminum tris(2,6-diphenylphenoxide) (ATPH). The origin of this efficient template effect by ATPH would be ascribable to the well-defined reaction environment created in front of the aluminum coordination center; this enables appropriate proximity of initially generated carbon radical to unsaturated carbon-carbon bond in the transition state for smooth cyclization and hence completely suppresses the undesired intermolecular reduction pathway. Moreover, such conformational restriction provided by the unique cavity of ATPH alters the stereoselectivity of the cyclization. (C) 2000 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S0040-4020(00)01007-3

DOI： 10.1016/s0040-4020(00)01007-3

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：GEORG THIEME VERLAG  

Significant rate enhancement was observed in the liquid-liquid phase-transfer catalytic epoxidations and alkylations under ultrasonic irradiation. Its advantage was also demonstrated in the asymmetric alkylation of tert-butyl glycinate-benzophenone Schiff base using C-2-symmetric chiral phase-transfer catalyst.

DOI： 10.1055/s-2000-7652

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

New type of fluoride ion catalyzed allylation agent (1a, 1b), allenylation agent (9, 10), and alkynylation agent (17) can be successfully utilized for various carbonyl substrates. The rate acceleration is ascribable to the shift of equilibrium to the chelate complexes with Bu4NF by the favorable chelation of bis(silyl) compounds toward the fluoride ion. The F-19 NMR spectrum (ethyl trifluoroacetate as external standard) of a mixture of 1a and Bu4NF in CDCl3 showed two peaks at delta -81.75 and -77.67 (integration ratio similar to 9:1). The large signal corresponds to the original peak of Bu4NF and the small one might be ascribed to the chelate complex [B] between la and Bu4NF. The fluoride ion mediated reaction of bis(crotyldimethylsilyl)methane (7) with benzaldehyde was examined and the only gamma-adduct 8 was obtained regioselectively. (C) 2000 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S0040-4020(00)00458-0

DOI： 10.1016/s0040-4020(00)00458-0

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：GEORG THIEME VERLAG  

Convenient, efficient preparation of aromatic sec-amides from esters has been accomplished using dilithium amides which are easily prepared by treatment of aromatic amines with 2 equiv of BuLi in THF. This new method allows a facile formation of amide bond even with sterically hindered esters.

DOI： 10.1055/s-1999-2731

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

Chemoselective functionalization of carbonyl compounds over acetals has been achieved by bidentate organoaluminum Lewis acid based on the selective double electrophilic activation of carbonyls. (C) 1997 Elsevier Science Ltd.

DOI： 10.1016/S0040-4039(97)01735-8

DOI： 10.1016/s0040-4039(97)01735-8

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