Graduate School of Science and Technology Advanced Materials Science and Technology Professor
Faculty of Engineering Department of Engineering Professor
Updated on 2024/12/12
博士(農学) ( 1996.3 京都大学 )
工学修士 ( 1989.3 京都大学 )
porous materials
分離材料
(bio)mechanical evaluation
bioengineering
membrane
Biofunction Bioprocess
Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Transport phenomena and unit operations
Nanotechnology/Materials / Structural materials and functional materials
Life Science / Applied microbiology
Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering
Life Science / Applied biochemistry
Niigata University Faculty of Engineering Department of Engineering Professor
2017.4
Niigata University Graduate School of Science and Technology Advanced Materials Science and Technology Professor
2013.4
Niigata University Graduate School of Science and Technology Advanced Materials Science and Technology Professor
2013.4
Niigata University Faculty of Engineering Department of Material Science and Technology Professor
2013.4 - 2017.3
Niigata University Faculty of Engineering Department of Material Science and Technology Associate Professor
2004.4 - 2013.3
Niigata University Faculty of Engineering Department of Material Science and Technology Associate Professor (as old post name)
1999.1 - 2004.3
Niigata University Faculty of Engineering Department of Material Science and Technology Lecturer
1996.5 - 1998.12
The Society of Chemical Engineers, Japan
The Membrane Society of Japan
The Society for Biotechnology, Japan
日本食品工学会
日本農芸化学会
Preparation of composite monoliths of quaternized chitosan and diatom earth for protein separation Reviewed
Takaaki Tanaka, Yuna Tomita, Koki Honda, Marino Fujisawa, Akihito Ochiai
Journal of Separation Science 46 ( 2 ) 2200638 - 2200638 2023.1
Preparation of polyhydroxyalkanoate microfiltration membranes via nonsolvent–induced phase separation methods Reviewed
Kazuyoshi Tabata, Toshiki Shibuya, Kousuke Karakida, Akihito Ochiai, Masayuki Taniguchi, Takaaki Tanaka
MEMBRANE 45 ( 6 ) 315 - 323 2020.11
Platelet adhesion on commercially pure titanium plates in vitro III: effects of calcium phosphate-blasting on titanium plate biocompatibility Reviewed
Nakamura, Masayuki, Aizawa, Hachidai, Kawabata, Hideo, Sato, Atsushi, Watanabe, Taisuke, Isobe, Kazushige, Kitamura, Yutaka, Tanaka, Takaaki, Kawase, Tomoyuki
International Journal of Implant Dentistry 6 74-1 - 74-14 2020.11
H. Minbu, H. Mizuno, Y. Shibuya, A. Ochiai, M. Taniguchi, T. Tanaka
Journal of Chemical Engineering of Japan 52 ( 1 ) 75 - 82 2019.1
Mechanical and degradation properties of advanced platelet-rich fibrin (A-PRF), concentrated growth factors (CGF), and platelet-poor plasma-derived fibrin (PPTF) Reviewed
Isobe Kazushige, Watanebe Taisuke, Kawabata Hideo, Kitamura Yutaka, Okudera Toshimitsu, Okudera Hajime, Uematsu Kohya, Okuda Kazuhiro, Nakata Koh, Tanaka Takaaki, Kawase Tomoyuki
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY 3 2017.5
Biomechanical evaluation by AFM of cultured human cell-multilayered periosteal sheets Reviewed
Makoto Horimizu, Tomoyuki Kawase, Takaaki Tanaka, Kazuhiro Okuda, Masaki Nagata, Douglas M. Burns, Hiromasa Yoshie
Micron 48 1 - 10 2013.5
Effects of SARS‑CoV‑2 mRNA vaccines on platelet polyphosphate levels and inflammation: A pilot study
Takashi Uematsu, Atsushi Sato, Hachidai Aizawa, Tetsuhiro Tsujino, Taisuke Watanabe, Kazushige Isobe, Hideo Kawabata, Yutaka Kitamura, Takaaki Tanaka, Tomoyuki Kawase
Biomedical Reports 16 ( 3 ) 2022.2
Crystal structure of rice defensin OsAFP1 and molecular insight into lipid-binding Reviewed
Akihito Ochiai, Kodai Ogawa, Minami Fukuda, Masami Suzuki, Kosuke Ito, Takaaki Tanaka, Yoshiyuki Sagehashi, Masayuki Taniguchi
Journal of Bioscience and Bioengineering 130 ( 1 ) 6 - 13 2020.7
Identification of cationic peptides derived from low protein rice by-products and evaluation of their multifunctional activities. Reviewed
Taniguchi M, Aida R, Saito K, Oya R, Ochiai A, Saitoh E, Tanaka T
Journal of Bioscience and Bioengineering 129 ( 3 ) 307 - 314 2020.3
Identification and characterization of multifunctional cationic peptides from enzymatic hydrolysates of soybean proteins. Reviewed
Masayuki Taniguchi, Ryousuke Aida, Kazuki Saito, Toyotaka Kikura, Akihito Ochiai, Eiichi Saitoh, Takaaki Tanaka
Journal of Bioscience and Bioengineering 129 ( 1 ) 59 - 66 2020.1
Wound healing activity and mechanism of action of antimicrobial and lipopolysaccharide-neutralizing peptides from enzymatic hydrolysates of rice bran proteins. Reviewed
Masayuki Taniguchi, Kazuki Saito, Ryousuke Aida, Akihito Ochiai, Eiichi Saitoh, Takaaki Tanaka
Journal of Bioscience and Bioengineering 128 ( 2 ) 142 - 148 2019.8
Evidence for contamination of silica microparticles in advanced platelet-rich fibrin matrices prepared using silica-coated plastic tubes Reviewed
T. Tsujino, A. Takahashi, S. Yamaguchi, T. Watanabe, K. Isobe, Y. Kitamura, T. Tanaka, K. Nakata, T. Kawase
Biomedicines 7 ( 2 ) 45-1 - 45-11 2019.6
Protein adsorption characteristics of nanoparticle-assembled hollow microspheres of hydroxyapatite and their composites with PLLA microporous membranes Reviewed
T. Tanaka, Y. Takai, A. Nagase, K. Teraguchi, H. Minbu, A. Ochiai, I. Kimura, M. Taniguchi
Heliyon 5 e01490-1 - e01490-22 2019.4
Identification and characterization of multifunctional cationic peptides from traditional Japanese fermented soybean Natto extracts. Reviewed
Masayuki Taniguchi, Ryousuke Aida, Kazuki Saito, Akihito Ochiai, Satoshi Takesono, Eiichi Saitoh, Takaaki Tanaka
Journal of Bioscience and bioengineering 127 ( 4 ) 472 - 478 2019.4
Cationic peptides from enzymatic hydrolysates of soybean proteins exhibit LPS-neutralizing and angiogenic activities. Reviewed
Masayuki Taniguchi, Yusuke Noda, Ryousuke Aida, Kazuki Saito, Akihito Ochiai, Eiichi Saitoh, Takaaki Tanaka
Journal of bioscience and bioengineering 127 ( 2 ) 176 - 182 2019.2
Spectrophotometric determination of platelet counts in platelet-rich plasma Reviewed
Y. Kitamura, M. Suzuki, T. Tsukioka, K. Isobe, T. Tsujino, T. Watanabe, T. Watanabe, H. Okudera, K. Nakata, T. Tanaka, T. Kawase
International Journal of Implant Dentistry 4 29-1 - 29-8 2018.10
Rice Defensin OsAFP1 is a New Drug Candidate against Human Pathogenic Fungi Reviewed
Ochiai Akihito, Ogawa Kodai, Fukuda Minami, Ohori Masahiro, Kanaoka Takumi, Tanaka Takaaki, Taniguchi Masayuki, Sagehashi Yoshiyuki
SCIENTIFIC REPORTS 8 2018.7
The antimicrobial and anti-endotoxic peptide AmyI-1-18 from rice α-amylase and its [N3L] analog promote angiogenesis and cell migration. Reviewed International journal
Masayuki Taniguchi, Akihito Ochiai, Toshiki Namae, Kazuki Saito, Tetsuo Kato, Eiichi Saitoh, Takaaki Tanaka
Peptides 104 78 - 84 2018.6
Platelet counts in insoluble platelet-rich fibrin clots: A direct method for accurate determination Reviewed
Yutaka Kitamura, Taisuke Watanabe, Masayuki Nakamura, Kazushige Isobe, Hideo Kawabata, Kohya Uematsu, Kazuhiro Okuda, Koh Nakata, Takaaki Tanaka, Tomoyuki Kawase
Frontiers in Bioengineering and Biotechnology 6 2018.2
An updated proposal for terminology and classification of platelet-rich fibrin Reviewed
Tomoyuki Kawase, Takaaki Tanaka
REGENERATIVE THERAPY 7 80 - 81 2017.12
Cationic peptides from peptic hydrolysates of rice endosperm protein exhibit antimicrobial, LPS-neutralizing, and angiogenic activities Reviewed
Masayuki Taniguchi, Junya Kawabe, Ryu Toyoda, Toshiki Namae, Akihito Ochiai, Eiichi Saitoh, Takaaki Tanaka
PEPTIDES 97 70 - 78 2017.11
Identification and characterization of multifunctional cationic peptides derived from peptic hydrolysates of rice bran protein Reviewed
Masayuki Taniguchi, Mitsuhiro Kameda, Toshiki Namae, Akihito Ochiai, Eiichi Saitoh, Takaaki Tanaka
JOURNAL OF FUNCTIONAL FOODS 34 287 - 296 2017.7
Identification and characterization of multifunctional cationic and amphipathic peptides from soybean proteins Reviewed
Masayuki Taniguchi, Kengo Saito, Takafumi Nomoto, Toshiki Namae, Akihito Ochiai, Eiichi Saitoh, Takaaki Tanaka
BIOPOLYMERS 108 ( 4 ) 2017.7
Platelet-rich fibrin prepared from stored whole-blood samples Reviewed
Isobe Kazushige, Suzuki Masashi, Watanabe Taisuke, Kitamura Yutaka, Suzuki Taiji, Kawabata Hideo, Nakamura Masayuki, Okudera Toshimitsu, Okudera Hajime, Uematsu Kohya, Nakata Koh, Tanaka Takaaki, Kawase Tomoyuki
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY 3 2017.3
Effects of arginine and leucine substitutions on anti-endotoxic activities andmechanisms of action of cationic and amphipathic antimicrobial octadecapeptide from rice alpha-amylase Reviewed
Masayuki Taniguchi, Akihito Ochiai, Ryu Toyoda, Teppei Sato, Eiichi Saitoh, Tetsuo Kato, Takaaki Tanaka
JOURNAL OF PEPTIDE SCIENCE 23 ( 3 ) 252 - 260 2017.3
M. Taniguchi, A. Ochiai, K. Takahashi, S. Nakamichi, T. Nomoto, E. Saitoh, T. Kato, T. Tanaka
Journal of Bioscience and Bioengineering 122 ( 6 ) 652 - 659 2016.12
H. Minbu, T. Kawase, A. Ochiai, M. Taniguchi, T. Tanaka
MEMBRANE 41 ( 6 ) 304 - 310 2016.11
Rice Bran Protein as a Potent Source of Antimelanogenic Peptides with Tyrosinase Inhibitory Activity Reviewed
Akihito Ochiai, Seiya Tanaka, Takaaki Tanaka, Masayuki Taniguchi
JOURNAL OF NATURAL PRODUCTS 79 ( 10 ) 2545 - 2551 2016.10
AmyI-1-18, a cationic alpha-helical antimicrobial octadecapeptide derived from alpha-amylase in rice, inhibits the translation and folding processes in a protein synthesis system Reviewed
Masayuki Taniguchi, Akihito Ochiai, Shun Fukuda, Teppei Sato, Eiichi Saitoh, Tetsuo Kato, Takaaki Tanakal
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 122 ( 4 ) 385 - 392 2016.10
New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues Reviewed
Akihito Ochiai, Seiya Tanaka, Yuta Imai, Hisashi Yoshida, Takumi Kanaoka, Takaaki Tanaka, Masayuki Taniguchi
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 121 ( 6 ) 607 - 613 2016.6
Pyrrhocoricin, a proline-rich antimicrobial peptide derived from insect, inhibits the translation process in the cell-free Escherichia coli protein synthesis system Reviewed
Masayuki Taniguchi, Akihito Ochiai, Hiroshi Kondo, Shun Fukuda, Yohei Ishiyama, Eiichi Saitoh, Tetsuo Kato, Takaaki Tanaka
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 121 ( 5 ) 591 - 598 2016.5
Effect of alanine, leucine, and arginine substitution on antimicrobial activity against candida albicans and action mechanism of a cationic octadecapeptide derived from -amylase of rice Reviewed
Masayuki Taniguchi, Akihito Ochiai, Kiyoshi Takahashi, Shun-ichi Nakamichi, Takafumi Nomoto, Eiichi Saitoh, Tetsuo Kato, Takaaki Tanaka
BIOPOLYMERS 106 ( 2 ) 219 - 229 2016.3
Endotoxin-neutralizing activity and mechanism of action of a cationic alpha-helical antimicrobial octadecapeptide derived from alpha-amylase of rice Reviewed
Masayuki Taniguchi, Akihito Ochiai, Kenta Matsushima, Koji Tajima, Tetsuo Kato, Eiichi Saitoh, Takaaki Tanaka
PEPTIDES 75 101 - 108 2016.1
The heat-compression technique for the conversion of platelet-rich fibrin preparation to a barrier membrane with a reduced rate of biodegradation Reviewed
Tomoyuki Kawase, Mana Kamiya, Mito Kobayashi, Takaaki Tanaka, Kazuhiro Okuda, Larry F. Wolff, Hiromasa Yoshie
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 103 ( 4 ) 825 - 831 2015.5
Quantitative single-cell motility analysis of platelet-rich plasma-treated endothelial cells in vitro Reviewed
Tomoyuki Kawase, Takaaki Tanaka, Kazuhiro Okuda, Makoto Tsuchimochi, Masafumi Oda, Toshiaki Hara
CYTOSKELETON 72 ( 5 ) 246 - 255 2015.5
Preparation of poly(L-lactic acid) microfiltration membranes by a nonsolvent-induced phase separation method with the aid of surfactants Reviewed
Hiromi Minbu, Akihito Ochiai, Tomoyuki Kawase, Masayuki Taniguchi, Douglas R. Lloyd, Takaaki Tanaka
JOURNAL OF MEMBRANE SCIENCE 479 85 - 94 2015.4
Antimicrobial Activity and Mechanism of Action of a Novel Cationic alpha-Helical Octadecapeptide Derived From alpha-Amylase of Rice Reviewed
Masayuki Taniguchi, Akihito Ochiai, Kiyoshi Takahashi, Shun-ichi Nakamichi, Takafumi Nomoto, Eiichi Saitoh, Tetsuo Kato, Takaaki Tanaka
BIOPOLYMERS 104 ( 2 ) 73 - 83 2015.3
Contribution of Cationic Amino Acids toward the Inhibition of Arg-Specific Cysteine Proteinase (Arg-gingipain) by the Antimicrobial Dodecapeptide, CL(14-25), from Rice Protein Reviewed
Masayuki Taniguchi, Yoshiyasu Matsuhashi, Takako K. Abe, Yohei Ishiyama, Eiichi Saitoh, Tetsuo Kato, Akihito Ochiai, Takaaki Tanaka
BIOPOLYMERS 102 ( 5 ) 379 - 389 2014.9
An atmospheric-pressure plasma-treated titanium surface potentially supports initial cell adhesion, growth, and differentiation of cultured human prenatal-derived osteoblastic cells Reviewed
Tomoyuki Kawase, Takaaki Tanaka, Hiromi Minbu, Mana Kamiya, Masafumi Oda, Toshiaki Hara
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 102 ( 6 ) 1289 - 1296 2014.8
Crystal structure of alpha-amylase from Oryza sativa: molecular insights into enzyme activity and thermostability Reviewed
Akihito Ochiai, Hiroshi Sugai, Kazuki Harada, Seiya Tanaka, Yohei Ishiyama, Kosuke Ito, Takaaki Tanaka, Toshio Uchiumi, Masayuki Taniguchi, Toshiaki Mitsui
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 78 ( 6 ) 989 - 997 2014.6
alpha-Amylase is a potential growth inhibitor of Porphyromonas gingivalis, a periodontal pathogenic bacterium Reviewed
A. Ochiai, K. Harada, K. Hashimoto, K. Shibata, Y. Ishiyama, T. Mitsui, T. Tanaka, M. Taniguchi
JOURNAL OF PERIODONTAL RESEARCH 49 ( 1 ) 62 - 68 2014.2
Effect of Substituting Arginine and Lysine with Alanine on Antimicrobial Activity and the Mechanism of Action of a Cationic Dodecapeptide (CL(14-25)), a Partial Sequence of Cyanate Lyase from Rice Reviewed
Masayuki Taniguchi, Nobuteru Takahashi, Tomohiro Takayanagi, Atsuo Ikeda, Yohei Ishiyama, Eiichi Saitoh, Tetsuo Kato, Akihito Ochiai, Takaaki Tanaka
BIOPOLYMERS 102 ( 1 ) 58 - 68 2014.1
Antimicrobial activity and mechanism of action of a novel cationic alpha-helical dodecapeptide, a partial sequence of cyanate lyase from rice Reviewed
Norihiro Takei, Nobuteru Takahashi, Tomohiro Takayanagi, Atsuo Ikeda, Kenji Hashimoto, Masahiro Takagi, Tsutomu Hamada, Eiichi Saitoh, Akihito Ochiai, Takaaki Tanaka, Masayuki Taniguchi
PEPTIDES 42 55 - 62 2013.4
Microporous membranes of PLLA/PCL blends for periosteal tissue scaffold Reviewed
Tomoaki Kouya, Shin-ichiro Tada, Hiromi Minbu, Yu Nakajima, Makoto Horimizu, Tomoyuki Kawase, Douglas R. Lloyd, Takaaki Tanaka
MATERIALS LETTERS 95 103 - 106 2013.3
Evaluation of positive interaction for cell growth between Bifidobacterium adolescentis and Propionibacterium freudenreichii using a co-cultivation system with two microfiltration modules Reviewed
Tomoaki Kouya, Yohei Ishiyama, Takaaki Tanaka, Masayuki Taniguchi
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 115 ( 2 ) 189 - 192 2013.2
Antimicrobial activity and mechanism of action of a novel cationic β-helical octadecapeptide derived from heat shock protein 70 of rice Reviewed
Masayuki Taniguchi, Atsuo Ikeda, Shun-Ichi Nakamichi, Yohei Ishiyama, Eiichi Saitoh, Tetsuo Kato, Akihito Ochiai, Takaaki Tanaka
Peptides 48 147 - 155 2013
Evaluation of positive interactions for cell growth between bifidobacterial strains and propionibacterium freudenreichii by using a co-cultivation system Reviewed
Tomoaki Kouya, Yohei Ishiyama, Takaaki Tanaka, Masayuki Taniguchi
Journal of Chemical Engineering of Japan 46 ( 3 ) 226 - 229 2013
Formation of depth filter microfiltration membranes of poly(L-lactic acid) via phase separation Reviewed
Takaaki Tanaka, Takayuki Nishimoto, Kazuhiro Tsukamoto, Masaharu Yoshida, Tomoaki Kouya, Masayuki Taniguchi, Douglas R. Lloyd
JOURNAL OF MEMBRANE SCIENCE 396 101 - 109 2012.4
An osteogenic grafting complex combining human periosteal sheets with a porous poly(L-lactic acid) membrane scaffold: Biocompatibility, biodegradability, and cell fate in vivo Reviewed
Tomoyuki Kawase, Takaaki Tanaka, Takayuki Nishimoto, Kazuhiro Okuda, Masaki Nagata, Douglas M. Burns, Hiromasa Yoshie
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 27 ( 2 ) 107 - 121 2012.3
Depth Filtration of Cell Suspensions of Agglomerated Streptobacteria by Biodegradable Membranes Reviewed
Masaharu Yoshida, Masayuki Taniguchi, Takaaki Tanaka
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 45 ( 9 ) 778 - 784 2012
Improved adhesion of human cultured periosteal sheets to a porous poly(L-lactic acid) membrane scaffold without the aid of exogenous adhesion biomolecules Reviewed
Tomoyuki Kawase, Takaaki Tanaka, Takayuki Nishimoto, Kazuhiro Okuda, Masaki Nagata, Douglas M. Burns, Hiromasa Yoshie
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 98A ( 1 ) 100 - 113 2011.7
Poly(L-lactic acid) Microfiltration Membrane Formation via Thermally Induced Phase Separation with Drying Reviewed
Takaaki Tanaka, Masatou Ueno, Youhei Watanabe, Tomoaki Kouya, Masayuki Taniguchi, Douglas R. Lloyd
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 44 ( 7 ) 467 - 475 2011
Growth-inhibition of hiochi bacteria in namazake (raw sake) by bacteriocins from lactic acid bacteria Reviewed
Masayuki Taniguchi, Yohei Ishiyama, Takeomi Takata, Toshihiro Nakanishi, Mitsuoki Kaneoke, Ken-ichi Watanabe, Fujitoshi Yanagida, Yi-sheng Chen, Tomoaki Kouya, Takaaki Tanaka
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 109 ( 6 ) 570 - 575 2010.6
Mechanical properties of microporous foams of biodegradable plastic Reviewed
Takaaki Tanaka, Takashi Aoki, Tomoaki Kouya, Masayuki Taniguchi, Wataru Ogawa, Yuuji Tanabe, Douglas R. Lloyd
DESALINATION AND WATER TREATMENT 17 ( 1-3 ) 37 - 44 2010.5
Filtration characteristics of carbon nanotubes and preparation of buckypapers Reviewed
Takaaki Tanaka
DESALINATION AND WATER TREATMENT 17 ( 1-3 ) 193 - 198 2010.5
Formation of microporous membranes of poly(1,4-butylene succinate) via nonsolvent and thermally induced phase separation Reviewed
Takaaki Tanaka, Masaki Takahashi, Shigeko Kawaguchi, Takeru Hashimoto, Hiroshi Saitoh, Tomoaki Kouya, Masayuki Taniguchi, Douglas R. Lloyd
DESALINATION AND WATER TREATMENT 17 ( 1-3 ) 176 - 182 2010.5
Enzymatic oxidative polymerization of methoxyphenols Reviewed
Takaaki Tanaka, Masafumi Takahashi, Hiroyuki Hagino, Shin-Ichi Nudejima, Hisaki Usui, Tomoyuki Fujii, Masayuki Taniguchi
CHEMICAL ENGINEERING SCIENCE 65 ( 1 ) 569 - 573 2010.1
M. Taniguchi, D. Takahashi, D. Watanabe, K. Sakai, K. Hoshino, T. Kouya, T. Tanaka
J. Biosci. Bioeng. 110 ( 4 ) 449 - 452 2010
Microfiltration of Bacterial Cell Suspensions with an Asymmetric Depth Filter Reviewed
Masaharu Yoshida, Masayuki Taniguchi, Takaaki Tanaka
KAGAKU KOGAKU RONBUNSHU 36 ( 5 ) 494 - 500 2010
Evaluation of Fungal Pretreatments for Enzymatic Saccharification of Rice Straw Reviewed
Masayuki Taniguchi, Daisuke Takahashi, Daisuke Watanabe, Kenji Sakai, Kazuhiro Hoshino, Tomoaki Kouya, Takaaki Tanaka
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 43 ( 4 ) 401 - 405 2010
上野 正統, 渡辺 洋平, 高屋 朋彰, 谷口 正之, 田中 孝明
化学工学会 研究発表講演要旨集 2010 1072 - 1072 2010
西本 崇之, 吉田 政晴, 高屋 朋彰, 谷口 正之, 田中 孝明
化学工学会 研究発表講演要旨集 2010 716 - 716 2010
吉田 政晴, 谷口 正之, 田中 孝明
化学工学会 研究発表講演要旨集 2010 715 - 715 2010
多田 晋一郎, 高屋 朋彰, 谷口 正之, 田中 孝明
化学工学会 研究発表講演要旨集 2010 971 - 971 2010
豊島 永祥, 高屋 朋彰, 谷口 正之, 田中 孝明
化学工学会 研究発表講演要旨集 2010 998 - 998 2010
Depth filter membranes of biodegradable biomass plastics
Takaaki Tanaka, Takayuki Nishimoto, Tomoaki Kouya, Masayuki Taniguchi, Douglas R. Lloyd
AIChE Annual Meeting, Conference Proceedings 2010
Growth-inhibitory activity of antimicrobial peptides from rice against oral pathogenic bacteria and clarification of their action mechanism Reviewed
Tomoaki Kouya, Yusuke Koiso, Mayumi Taiyouji, Sadami Ohtsubo, Takaaki Tanaka, Masayuki Taniguchi
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 108 S141 - S141 2009.11
Growth-inhibition of Lactobacillus hilgardii, a bacterium related to hiochi, in the mizu-koji process by bacteriocins from lactic acid bacteria. Reviewed
Y. Ishiyama, T. Takata, T. Nakanishi, M. Kaneoke, K. Watanabe, F. Yanagida, Y. Chen, T. Kouya, T. Tanaka, M. Taniguchi
Jpn. J. Food Eng. 10 ( 1 ) 45 - 53 2009
Microfiltration of Incompressible Particle Suspension with an Asymmetric Depth Filter Reviewed
Takaaki Tanaka, Tomoya Mimura, Mitsuo Koga, Masaharu Yoshida, Masayuki Taniguchi, Kazuhiro Nakanishi
KAGAKU KOGAKU RONBUNSHU 35 ( 1 ) 81 - 86 2009
Enzymatic treatment of estrogens and estrogen glucuronide Reviewed
Takaaki Tanaka, Toshiyuki Tamura, Yuuichi Ishizaki, Akito Kawasaki, Tomokazu Kawase, Masahiro Teraguchi, Masayuki Taniguchi
JOURNAL OF ENVIRONMENTAL SCIENCES 21 ( 6 ) 731 - 735 2009
Microporous foams of polymer blends of poly(L-lactic acid) and poly(epsilon-caprolactone) Reviewed
Takaaki Tanaka, Satoko Eguchi, Hiroshi Saitoh, Masayuki Taniguchi, Douglas R. Lloyd
DESALINATION 234 ( 1-3 ) 175 - 183 2008.12
Yohei Ishiyama, Takeomi Takata, Toshihiro Nakanishi, Naomi Watanabe, Mistuoki Kaneoke, Ken-Ichi Watanabe, Takaaki Tanaka, Masayuki Taniguchi
Food Science and Technology Research 14 ( 3 ) 239 - 248 2008.5
Production of bacteriocin by Staphylococcus sp NPSI 38 in koji extract medium with rice protein hydrolyzate and its growth-inhibitory activity against hiochi-bacteria Reviewed
Yohei Ishiyama, Takeomi Takata, Toshihiro Nakanishi, Naomi Watanabe, Mistuoki Kaneoke, Ken-ichi Watanabe, Takaaki Tanaka, Masayuki Taniguchi
FOOD SCIENCE AND TECHNOLOGY RESEARCH 14 ( 3 ) 239 - 248 2008.5
Production of extracellular bifidogenic growth stimulator (BGS) from Propionibacterium shermanii using a bioreactor system with a microfiltration module and an on-line controller for lactic acid concentration Reviewed
Tomoaki Kouya, Kazuhiro Tobita, Masahito Horiuchi, Eri Nakayama, Hiroyoshi Deguchi, Takaaki Tanaka, Masayuki Taniguchi
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 105 ( 3 ) 184 - 191 2008.3
Production of Bifidogenic Growth Stimulator by Co-cultivation of Propionibacterium shermanii and Lactobacillus Strain Using Lactose as a Carbon Source Reviewed
Tomoaki Kouya, Masahiro Horiuchi, Kazuhiro Tobita, Katsuhiro Misawa, Eri Nakayama, Hiroyoshi Deguchi, Takaaki Tanaka, Masayuki Taniguchi
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 41 ( 6 ) 492 - 496 2008
Production of extracellular bifidogenic growth stimulator by anaerobic and, aerobic cultivations of several propionibacterial strains Reviewed
Tomoaki Kouya, Katsuhiro Misawa, Masahito Horiuchi, Eri Nakayama, Hiroyoshi Deguchi, Takaaki Tanaka, Masayuki Taniguchi
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 103 ( 5 ) 464 - 471 2007.5
Production of laccase by membrane-surface liquid culture of Trametes versicolor using a poly(L-lactic acid) membrane Reviewed
Takaaki Tanaka, Satoko Eguchi, Takashi Aoki, Toshiyuki Tamura, Hiroshi Saitoh, Masayuki Taniguchi, Hitomi Ohara, Kazuhiro Nakanishi, Douglas R. Lloyd
BIOCHEMICAL ENGINEERING JOURNAL 33 ( 2 ) 188 - 191 2007.2
プロピオン酸菌の嫌気培養と好気培養によるビフィズス菌増殖因子生産の比較解析
高屋 朋彰, 出口 央視, 田中 孝明, 谷口 正之
化学工学会 研究発表講演要旨集 2007 811 - 811 2007
乳酸菌バクテリオシンによる清酒製造工程における火落菌の殺菌法の開発
石山 洋平, 高田 剛臣, 小磯 裕介, 金桶 光起, 渡邊 健一, 田中 孝明, 谷口 正之
化学工学会 研究発表講演要旨集 2007 812 - 813 2007
高橋 真記, 川口 滋子, 齋藤 浩, 谷口 正之, Lloyd D. R., 田中 孝明
化学工学会 研究発表講演要旨集 2007 535 - 535 2007
Microfiltration membrane of polymer blend of poly(L-lactic acid) and poly(epsilon-caprolactone) Reviewed
T Tanaka, T Tsuchiya, H Takahashi, T Masayuki, DR Lloyd
DESALINATION 193 ( 1-3 ) 367 - 374 2006.5
Formation of biodegradable polyesters membranes via thermally induced phase separation Reviewed
T Tanaka, T Tsuchiya, H Takahashi, M Taniguchi, H Ohara, DR Lloyd
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 39 ( 2 ) 144 - 153 2006.2
Production of D-lactic acid from defatted rice bran by simultaneous saccharification and fermentation Reviewed
T Tanaka, M Hoshina, S Tanabe, K Sakai, S Ohtsubo, M Taniguchi
BIORESOURCE TECHNOLOGY 97 ( 2 ) 211 - 217 2006.1
麹汁培地を用いて生産した乳酸菌バクテリオシンによる清酒の火落ち防止 Reviewed
石山 洋平, 中西 利公, 高田 剛臣, 金桶 光起, 渡邊 健一, 成田 護, 田中 孝明, 谷口 正之
化学工学会 研究発表講演要旨集 2006 ( 0 ) 402 - 402 2006
精米残渣の高速酵素糖化とその発酵原料としての有効利用 Reviewed
樋口 裕樹, 加藤 壮司, 尾崎 雄一, 金本 繁晴, 田中 孝明, 谷口 正之
化学工学会 研究発表講演要旨集 2006 ( 0 ) 403 - 403 2006
チーズ製造用プロピオン酸菌の好気培養によるBGS生産とその代謝変動の解析
高屋 朋彰, 中山 惠理, 出口 央視, 田中 孝明, 谷口 正之
化学工学会 研究発表講演要旨集 2006 401 - 401 2006
表面凹凸構造により実効濾過面積を拡大した生分解性プラスチック濾過板の開発
田中 孝明, 指方 太陽, 青木 卓史, 齋藤 浩, 谷口 正之, Lloyd D. R.
化学工学会 研究発表講演要旨集 2006 258 - 258 2006
加水分解酵素-酸化酵素-複合酵素系を用いた女性ホルモン及びその抱合体の酵素処理
田中 孝明, 石崎 雄一, 田村 俊幸, 川瀬 智一, 谷口 正之
化学工学会 研究発表講演要旨集 2006 944 - 944 2006
Production of L-lactic acid by simultaneous saccharification and fermentation using unsterilized defatted rice bran as a carbon source and nutrient components Reviewed
M Taniguchi, M Hoshina, S Tanabe, Y Higuchi, K Sakai, S Ohtsubo, K Hoshino, T Tanaka
FOOD SCIENCE AND TECHNOLOGY RESEARCH 11 ( 4 ) 400 - 406 2005.12
Evaluation of pretreatment with Pleurotus ostreatus for enzymatic hydrolysis of rice straw Reviewed
M Taniguchi, H Suzuki, D Watanabe, K Sakai, K Hoshino, T Tanaka
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 100 ( 6 ) 637 - 643 2005.12
デプスフィルターによる菌体の濾過 Reviewed
田中 孝明, 三村 朋也, 古賀 光雄, 吉田 政晴, 谷口 正之, 中西 一弘
化学工学会 研究発表講演要旨集 2005 ( 0 ) 408 - 408 2005
未殺菌米ぬかを原料とした乳酸発酵の低コスト化 Reviewed
樋口 裕樹, 渡邊 大助, 保科 昌宏, 田中 孝明, 谷口 正之
化学工学会 研究発表講演要旨集 2005 ( 0 ) 721 - 721 2005
担子菌によって脱リグニン処理した稲わらの乳酸とエタノールへの微生物変換 Reviewed
渡邊 大助, 鈴木 弘之, 樋口 裕樹, 田中 孝明, 谷口 正之
化学工学会 研究発表講演要旨集 2005 ( 0 ) 720 - 720 2005
Production of L-lactic acid from a mixture of xylose and glucose by co-cultivation of lactic acid bacteria Reviewed
M Taniguchi, T Tokunaga, K Horiuchi, K Hoshino, K Sakai, T Tanaka
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 66 ( 2 ) 160 - 165 2004.12
Formation of poly(L-lactic acid) microfiltration membranes via thermally induced phase separation Reviewed
T Tanaka, DR Lloyd
JOURNAL OF MEMBRANE SCIENCE 238 ( 1-2 ) 65 - 73 2004.7
Clarification of interactions among microorganisms and development of co-culture system for production of useful substances Reviewed
M Taniguchi, T Tanaka
RECENT PROGRESS OF BIOCHEMICAL AND BIOMEDICAL ENGINEERING IN JAPAN I 90 35 - 62 2004
Treatment of nonylphenol with laccase in a rotating reactor Reviewed
T Tanaka, M Nose, A Endo, T Fujii, M Taniguchi
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 96 ( 6 ) 541 - 546 2003.12
Enzymatic oxidative polymerization of 4-chloroguaiacol by laccase Reviewed
T Tanaka, M Yamamoto, M Takahashi, T Fujii, M Taniguchi
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 36 ( 9 ) 1101 - 1106 2003.9
Relationship between cake structure and membrane pore size in crossflow filtration of microbial cell suspension containing fine particles Reviewed
T Tanaka, Y Yamagiwa, T Nagano, M Taniguchi, K Nakanishi
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 34 ( 12 ) 1524 - 1531 2001.12
T. Tanaka, T. Tonosaki, M. Nose, N. Tomidokoro, N. Kadomura, T. Fujii, M. Taniguchi
Journal of Bioscience and Bioengineering 92 ( 4 ) 312 - 316 2001
Kefiran Production by Lactobacillus kefiranofaciens under the Culture Conditions Established by Mimicking the Existence and Activities of Yeast in Kefir Grains Reviewed
Masayuki Taniguchi, Masashi Nomura, Takahiro Itaya, Takaaki Tanaka
Food Science and Technology Research 7 ( 4 ) 333 - 337 2001
Enzymatic degradation of alkylphenols, bisphenol A, synthetic estrogen and phthalic ester Reviewed
T Tanaka, K Yamada, T Tonosaki, T Konishi, H Goto, M Taniguchi
WATER SCIENCE AND TECHNOLOGY 42 ( 7-8 ) 89 - 95 2000
Production of a mixture of antimicrobial organic acids from lactose by co-culture of Bifidobacterium longum and Propionibacterium freudenreichii Reviewed
M Taniguchi, H Nakazawa, O Takeda, T Kaneko, K Hoshino, T Tanaka
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 62 ( 8 ) 1522 - 1527 1998.8
Formation of the gel layer of polymers and its effect on the permeation flux in crossflow filtration of Corynebacterium glutamicum broth Reviewed
T Tanaka, K Usui, K Nakanishi
SEPARATION SCIENCE AND TECHNOLOGY 33 ( 5 ) 707 - 722 1998
Characteristics in crossflow filtration using different yeast suspensions Reviewed
T Tanaka, S Tsuneyoshi, W Kitazawa, K Nakanishi
SEPARATION SCIENCE AND TECHNOLOGY 32 ( 11 ) 1885 - 1898 1997
Filtration behaviors of rod-shaped bacterial broths in unsteady-state phase of cross-flow filtration Reviewed
T Tanaka, K Usui, K Kouda, K Nakanishi
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 29 ( 6 ) 973 - 981 1996.12
CROSS-FLOW FILTRATION OF BAKERS-YEAST WITH PERIODICAL STOPPING OF PERMEATION FLOW AND BUBBLING Reviewed
T TANAKA, H ITOH, K ITOH, K NAKANISHI, T KUME, R MATSUNO
BIOTECHNOLOGY AND BIOENGINEERING 47 ( 3 ) 401 - 404 1995.8
SYNTHESIS OF ASPARTAME PRECURSOR WITH AN IMMOBILIZED THERMOLYSIN IN MIXED ORGANIC-SOLVENTS Reviewed
M MIYANAGA, T TANAKA, T SAKIYAMA, K NAKANISHI
BIOTECHNOLOGY AND BIOENGINEERING 46 ( 6 ) 631 - 635 1995.6
PRODUCTION OF KOJIC ACID FROM ASPERGILLUS-ORYZAE VAR ORYZAE BY MEMBRANE-SURFACE LIQUID CULTURE Reviewed
A OGAWA, Y MORITA, T TANAKA, T SAKIYAMA, K NAKANISHI
BIOTECHNOLOGY TECHNIQUES 9 ( 2 ) 153 - 156 1995.2
PRODUCTION OF KOJIC ACID BY MEMBRANE-SURFACE LIQUID CULTURE OF ASPERGILLUS-ORYZAE NRRL484 Reviewed
A OGAWA, Y WAKISAKA, T TANAKA, T SAKIYAMA, K NAKANISHI
JOURNAL OF FERMENTATION AND BIOENGINEERING 80 ( 1 ) 41 - 45 1995
PRODUCTION OF NEUTRAL PROTEASE BY MEMBRANE-SURFACE LIQUID CULTURE OF ASPERGILLUS-ORYZAE IAM2704 Reviewed
A OGAWA, A YASUHARA, T TANAKA, T SAKIYAMA, K NAKANISHI
JOURNAL OF FERMENTATION AND BIOENGINEERING 80 ( 1 ) 35 - 40 1995
SYNTHESIS OF ASPARTAME PRECURSOR WITH AN IMMOBILIZED THERMOLYSIN IN TERT-AMYL ALCOHOL Reviewed
T NAGAYASU, M MIYANAGA, T TANAKA, T SAKIYAMA, K NAKANISHI
BIOTECHNOLOGY AND BIOENGINEERING 43 ( 11 ) 1118 - 1123 1994.5
CROSS-FLOW FILTRATION OF YEAST BROTH CULTIVATED IN MOLASSES Reviewed
T TANAKA, R KAMIMURA, R FUJIWARA, K NAKANISHI
BIOTECHNOLOGY AND BIOENGINEERING 43 ( 11 ) 1094 - 1101 1994.5
SYNTHESIS OF DIPEPTIDE PRECURSORS WITH AN IMMOBILIZED THERMOLYSIN IN ETHYL-ACETATE Reviewed
T NAGAYASU, M MIYANAGA, T TANAKA, T SAKIYAMA, K NAKANISHI
BIOTECHNOLOGY AND BIOENGINEERING 43 ( 11 ) 1108 - 1117 1994.5
PRODUCTION OF NEUTRAL PROTEASE FROM ASPERGILLUS-ORYZAE BY A NOVEL CULTIVATION METHOD ON A MICROPOROUS MEMBRANE
A YASUHARA, A OGAWA, T TANAKA, T SAKIYAMA, K NAKANISHI
BIOTECHNOLOGY TECHNIQUES 8 ( 4 ) 249 - 254 1994.4
SHEAR-INDUCED ARRANGEMENT OF CELLS IN CAKE DURING CROSS-FLOW FILTRATION OF ESCHERICHIA-COLI-CELLS Reviewed
T TANAKA, K ABE, K NAKANISHI
BIOTECHNOLOGY TECHNIQUES 8 ( 1 ) 57 - 60 1994.1
FILTRATION CHARACTERISTICS AND STRUCTURE OF CAKE IN CROSS-FLOW FILTRATION OF BACTERIAL SUSPENSION
T TANAKA, K ABE, H ASAKAWA, H YOSHIDA, K NAKANISHI
JOURNAL OF FERMENTATION AND BIOENGINEERING 78 ( 6 ) 455 - 461 1994
Factors affecting the performance of crossflow filtration of yeast cell suspension Reviewed
T Tanaka, K Nakanishi
DEVELOPMENTS IN FOOD ENGINEERING, PTS 1 AND 2 653 - 655 1994
IMPROVEMENT OF PERFORMANCE FOR CROSS-FLOW MEMBRANE FILTRATION OF PULLULAN BROTH Reviewed
H YAMASAKI, MS LEE, T TANAKA, K NAKANISHI
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 39 ( 1 ) 21 - 25 1993.4
CHARACTERISTICS OF CROSS-FLOW FILTRATION OF PULLULAN BROTH Reviewed
H YAMASAKI, MS LEE, T TANAKA, K NAKANISHI
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 39 ( 1 ) 26 - 30 1993.4
FACTORS AFFECTING THE PERFORMANCE OF CROSS-FLOW FILTRATION OF YEAST-CELL SUSPENSION Reviewed
T TANAKA, R KAMIMURA, K ITOH, K NAKANISHI, R MATSUNO
BIOTECHNOLOGY AND BIOENGINEERING 41 ( 6 ) 617 - 624 1993.3
SOME FACTORS AFFECTING THE FORMATION OF GAMMA-CYCLODEXTRIN USING CYCLODEXTRIN GLYCOSYLTRANSFERASE FROM BACILLUS SP AL-6 Reviewed
K TOMITA, T TANAKA, Y FUJITA, K NAKANISHI
JOURNAL OF FERMENTATION AND BIOENGINEERING 70 ( 3 ) 190 - 192 1990
Enzymatic synthesis of L-glutamic acid dimer precursor with immobilized papain in an organic solvent Reviewed
Takaaki Tanaka, Kenji Tomita, Kazuhiro Nakanishi
Chemistry Express 5 ( 7 ) 525 - 528 1990
CONTINUOUS PRODUCTION OF L-SERINE BY IMMOBILIZED GROWING CORYNEBACTERIUM-GLYCINOPHILUM CELLS Reviewed
T TANAKA, K YAMAMOTO, S TOWPRAYOON, H NAKAJIMA, K SONOMOTO, K YOKOZEKI, K KUBOTA, A TANAKA
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 30 ( 6 ) 564 - 568 1989.6
Production, Forming/Molding, and High-Performance Technologies of Poly(lactic acid)
Hiroshi Uyama, Yu-I Hsu, Takaaki Tanaka, And Others( Role: Joint author)
CMC Publishing Co.,Ltd. 2024.1 ( ISBN:9784781317649 )
食品製造に役立つ食品工学事典
日本食品工学会編, 田中孝明他( Role: Joint author)
2020.12
カーボンナノチューブの表面処理・分散技術と複合化事例
技術情報協会編, 田中孝明( Role: Joint author)
技術情報協会 2019.12 ( ISBN:9784861047725 )
生分解性プラスチックの素材・技術開発
望月政嗣, 監修, 田中孝明, 他, 著( Role: Joint author)
エヌ・ティー・エス 2019.12 ( ISBN:9784860436230 )
多孔質フィルム/膜の製造技術
田中孝明, 佐光貞樹, 富康博, 川島敏行, 石塚紀生, 瀧健太郎, 串﨑義幸, 平井悠司, 下村政嗣, 横山英明, 早川晃鏡, 武野明義, 高橋紳矢, 松田裕行, 小野寺恒信, 笠井均, 及川英俊, 山田一博, 河野公一, 西川聡( Role: Joint author)
S&T出版 2016.6 ( ISBN:4907002564 )
濾過スケールアップの正しい進め方と成功事例集
技術情報協会編, 田中孝明
技術情報協会 2014.8 ( ISBN:9784861045370 )
化学便覧 応用化学編 第7版
日本化学会編, 田中孝明
丸善出版 2014.1 ( ISBN:9784621087596 )
濾過プロセスの最適選定と効率改善
情報機構編, 田中孝明
情報機構 2010.10 ( ISBN:9784904080610 )
カーボンナノチューブの精製・前処理と分散・可溶化技術
技術情報協会編, 田中孝明
技術情報協会 2009.4 ( ISBN:9784861042829 )
産業酵素の応用技術と最新動向
井上國世監修, 田中孝明
シーエムシー出版 2009.3 ( ISBN:9784781301082 )
バイオプロダクション
化学工学会バイオ部会編, 田中孝明
コロナ社 2006.5 ( ISBN:9784339067361 )
食品工学ハンドブック
日本食品工学会編, 田中孝明( Role: Joint author)
朝倉書店 2006.1 ( ISBN:9784254430912 )
化学工学の進歩39,粒子・流体系フロンティア分離技術
化学工学会編, 田中孝明
槇書店 2005.10 ( ISBN:9784837506881 )
生物工学ハンドブック
日本生物工学会編, 田中孝明
コロナ社 2005.6 ( ISBN:9784339067347 )
Clarification of Interactions among Microorganisms and Development of Co-culture System for Production of Useful Substances
Adv. Biochem. Engin./Biotechnol., Springer 2004
Treatment of phenolic endocrine-disrupting chemicals by lignin-degrading enzymes.
Wastewater Treatment Using Enzymes, Research Signpost, Kerala, India 2003
Permation behaviors in crossflow microfiltration of microbial suspensions containing fine particles and polymers.
Proceedings of The First Conference of Aseanian Membrane Society, Tokyo, Japan 2002
Crossflow filtration of lactic acid bacteria: effects of cell shapes and dextran on permeation flux.
Proceedings of The First Conference of Aseanian Membrane Society, Tokyo, Japan 2002
Formation and Structural Change of Cake during Crossflow Microfiltration of Microbial Cell Suspension Containing Fine Particles(jointly worked)
Bioseparation Engineering 2000
On the stability of immobilized thermolysin in an organic solvent(jointly worked)
Chemical Engineering Symposium Series 57, The Society of Chemical Engineers, Japan 1997
Development of membrane-surface liquid culture of molds(jointly worked)
1995
Optimization for synthesis of aspartame precursor using an immobilized thermolysin in an organic solvent(jointly worked)
Chemical Engineering Symposium Series 44, The Society of Chemical Engineers, Japan 1995
Crossflow filtration of microbial suspensions(jointly worked)
Continental Press Singapore, Better living through innovative biochemical engineering 1994
生物工学実験書
日本生物工学会編, 田中孝明
培風館 1992.10 ( ISBN:4563077178 )
Crossflow membrane filtration of highly viscous microbial broth(jointly worked)
S. Furusaki, I. Endo, R. Matsuno, Springer Verlag Tokyo, Biochemical Engineering for 2001 1992
ヒト唾液タンパク質由来ペプチドのACE阻害活性
丸山輝, 樋口真伍, 田邊聡美, 田中孝明, 田中孝明, 谷口正之, 斎藤英一, 落合秋人, 落合秋人
日本生化学会大会(Web) 95th 2022
Preparation of active recombinant human tyrosinase and elucidation of its enzymatic properties
柴田陽樹, 矢内あすか, 田中孝明, 田中孝明, 谷口正之, 落合秋人, 落合秋人
日本農芸化学会大会講演要旨集(Web) 2022 2022
Preparation and evaluation of poly(lactic acid) microfiltration membranes using γ-butyrolactone.
田中孝明, 柄木田航介, 渋谷俊輝, 落合秋人, 谷口正之
日本膜学会年会講演要旨集(CD-ROM) 43rd 2021
バイオマス由来溶媒Cyreneを用いたポリ乳酸膜の作製
長田朋晃, 落合秋人, 谷口正之, 田中孝明
膜シンポジウム(CD-ROM) ( 33 ) 2021
Structures of porous membranes and their capture of particles Invited Reviewed
MEMBRANE 45 ( 1 ) 15 - 21 2020.1
Analysis of apoptosis induction mechanism in antifungal defensin
落合秋人, 小川広大, 田中孝明, 提箸祥幸, 谷口正之
日本農芸化学会大会講演要旨集(Web) 2020 2020
Cyreneを溶媒として用いた相分離法によるポリ乳酸膜の作製
長田朋晃, 落合秋人, 谷口正之, 田中孝明
化学工学会秋季大会研究発表講演要旨集(CD-ROM) 51st 2020
ディップコーティング法による管状キトサン-アルギン酸-交互複合膜の作製
西村亮太, 落合秋人, 谷口正之, 田中孝明
日本膜学会年会講演要旨集 41st 2019
イネにおける新規な抗真菌タンパク質の探索
三井田篤志, 落合秋人, 田中孝明, 提箸祥幸, 谷口正之
日本生物工学会大会講演要旨集 71st 2019
界面活性剤を利用して作製したポリ乳酸製デプスフィルターの濾過特性
田中孝明, 民部裕洋, 水野陽樹, 渋谷裕紀, 落合秋人, 谷口正之
日本食品工学会年次大会講演要旨集 19th 2018
コメ糠タンパク質由来多機能型カチオン性ペプチドの創傷治癒作用とその機構の解明
斉藤寿槻, 生江俊樹, 落合秋人, 田中孝明, 谷口正之
日本生物工学会大会講演要旨集 70th 2018
食品タンパク質酵素加水分解物中に含まれるカチオン性抗菌ペプチドの創傷治癒活性とその作用機構
谷口正之, 斉藤寿槻, 生江俊樹, 落合秋人, 田中孝明
日本農芸化学会大会講演要旨集(Web) 2018 2018
培養細胞を用いたコメ糠タンパク質由来抗菌ペプチドの創傷治癒作用とその機構の解明
斉藤寿槻, 生江俊樹, 落合秋人, 田中孝明, 谷口正之
日本生物工学会大会講演要旨集 69th 2017
Chronic Inhalation Of Recombinant Human Granulocyte/ macrophage Colony Stimulating Factor (gm-Csf) And Gm-Csf Antibody In Nonhuman Primates
R. Tazawa, K. Nakagaki, Y. Ito, M. Iizuka, A. Hashimoto, R. Nakano, T. Tanaka, K. Akasaka, S. Takeuchi, K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 195 2017
コメ糠タンパク質酵素加水分解物からのカチオン性ペプチドの精製と同定およびその生理活性の解明
谷口正之, 亀田光裕, 落合秋人, 田中孝明
日本生物工学会大会講演要旨集 68th 2016
納豆水抽出物中のカチオン性ペプチドの精製と同定およびその生理活性の解析
野本貴史, 幡本晃太, 落合秋人, 田中孝明, 谷口正之
日本生物工学会大会講演要旨集 68th 2016
コメ糠タンパク質酵素加水分解物からのカチオン性ペプチドの精製とその生理活性の解明
谷口正之, 亀田光裕, 落合秋人, 田中孝明
日本農芸化学会大会講演要旨集(Web) 2016 2016
ローヤルゼリー酵素加水分解物からの生理活性ペプチドの精製と同定およびその機能解析
平塚祐也, 川部純弥, 落合秋人, 田中孝明, 谷口正之
日本生物工学会大会講演要旨集 68th 2016
大豆タンパク質酵素加水分解物からの生理活性ペプチドの精製と同定およびその機能解析
野田悠輔, 川部純弥, 落合秋人, 田中孝明, 谷口正之
日本生物工学会大会講演要旨集 68th 2016
大豆タンパク質由来カチオン性ペプチドの抗菌・抗炎症・創傷治癒活性の解析
齊藤健吾, 野本貴史, 落合秋人, 田中孝明, 谷口正之
日本生物工学会大会講演要旨集 68th 2016
Light Chain Genotype Analysis Of Gm-Csf Autoantibody In Autoimmune Pulmonary Alveolar ProteINOSis By Next Generation Sequencing
A. Hashimoto, T. Tanaka, A. Hayakawa, Y. Itoh, T. Nei, K. Shiiya, M. Higuchi, K. Nakagaki, T. Takada, K. Akasaka, R. Tazawa, K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 193 2016
Early And Late Onset Adverse Events In Lam Patients Treated With Sirolimus For Two Years
K. Nakata, Y. Inoue, K. Seyama, R. Tazawa, T. Tamada, A. Mikami, H. Nakayama, M. Suzuki, M. Ebina, M. Hanaoka, N. Hattori, T. Hirai, T. Arai, C. Sugimoto, N. Kitamura, T. Tanaka, K. Akazawa, M. Mishima
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 193 2016
Early Intervention With Sirolimus Benefits Mild Lymphangioleiomyomatosis-Related Lung Disease
T. Takada, K. Seyama, Y. Inoue, K. Nagai, M. Suzuki, H. Moriyama, K. Akasaka, R. Tazawa, T. Hirai, M. Mishima, M. Hayashida, M. Hirose, C. Sugimoto, T. Arai, N. Hattori, K. Watanabe, A. Mikami, T. Tamada, H. Yoshizawa, K. Akazawa, T. Tanaka, N. Kitamura, K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 193 2016
Cultured Cell Sheets Supported by Microporous Membranes of Biodegradable Polyesters
民部裕洋, 田中孝明
膜 40 ( 3 ) 124 - 129 2015.5
Kawabe Jun-ya, Kameda Mitsuhiro, Hiratsuka Yuya, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
67 157 - 157 2015
Nomoto Takafumi, Saito Kengo, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
67 156 - 156 2015
Sato Teppei, Fukuda Shun, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
67 156 - 156 2015
Taniguchi Masayuki, Kaneko Akinori, Tajima Koji, Ochiai Akihito, Tanaka Takaaki
67 156 - 156 2015
1P-274 Preparation of recombinant defensin from Oryza sativa and analysis of its functions
Ohori Masahiro, Kanaoka Takumi, Ochiai Akihito, Sagehashi Yoshiyuki, Tanaka Takaaki, Taniguchi Masayuki
67 157 - 157 2015
納豆抽出物からのカチオン性抗菌ペプチド成分の調製とその特性解析
幡本晃太, 亀田光裕, 松嶋健太, 落合秋人, 田中孝明, 谷口正之
日本農芸化学会大会講演要旨集(Web) 2015 2015
A Novel Method For Measuring Low Concentration Of Gm-Csf Autoantibody In The Sera Of Healthy Subjects
K. Shiiya, A. Hashimoto, T. Tanaka, K. Akasaka, Y. Itoh, R. Tazawa, K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 191 2015
Outcome Of Corticosteroids Therapy In Autoimmune Pulmonary Alveolar ProteINOSis
K. Akasaka, T. Tanaka, K. Shiiya, A. Hashimoto, H. Ishii, S. Ohkouchi, R. Tazawa, N. Kitamura, T. Takada, K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 191 2015
Gm-Csf Autoantibody Does Not Completely Interfere The Binding Of Gm-Csf To Its Receptor But Blocks Gm-Csf Signaling Strongly
A. Hashimoto, T. Tanaka, M. Higuchi, Y. Itoh, K. Shiiya, K. Akasaka, R. Tazawa, K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 191 2015
A Mathematical Model That Estimates The Amount Of Eliminated Gm-Csf Autoantibody By Whole-Lung Lavage In Autoimmune Pulmonary Alveolar ProteINOSis
T. Tanaka, K. Akasaka, T. Maruyama, N. Kitamura, A. Hashimoto, K. Shiiya, Y. Itoh, S. Ohkouchi, R. Tazawa, E. Yamaguchi, T. Ichiwata, M. Hirose, T. Arai, Y. Inoue, H. Kobayashi, K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 191 2015
Inhalation Of Recombinant Human Granulocyte/macrophage-Colony Stimulating Factor And Induction Of The Gm-Csf Antibody In Pulmonary Alveolar ProteINOSis
R. Tazawa, K. Nakagaki, Y. Ito, A. Hashimoto, T. Tanaka, K. Akasaka, K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 191 2015
Depth Filtration of Solid–Liquid Suspensions by Using Membranes
Tanaka Takaaki
MEMBRANE 39 ( 1 ) 21 - 27 2014
2P-043 Functional analysis of endotoxin-neutralizing effect of α-amylase from Oryza sativa
Watanabe Kazuhito, Ochiai Akihito, Sugai Hiroshi, Tanaka Takaaki, Taniguchi Masayuki
66 117 - 117 2014
2P-044 Analysis of interaction between endotoxin and α-amylase from oryza sativa
Sugai Hiroshi, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
66 117 - 117 2014
Takahashi Kiyoshi, Nakamichi Shun-ichi, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
66 167 - 167 2014
1P-102 Production of recombinant human tyrosinase using Escherichia coli expression system.
Kanaoka Takumi, Tanaka Seiya, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
66 42 - 42 2014
Kaneko Akinori, Tajima Koji, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
66 167 - 167 2014
Kameda Mitsuhiro, Matsushima Kenta, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
66 168 - 168 2014
1P-101 Analysis of the action mechanism of tyrosinase inhibitory peptides
Imai Yuta, Tanaka Seiya, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
66 42 - 42 2014
2P-042 Crystal Structure of α-Amylase AmyI-1 from Oryza sativa
Ochiai Akihito, Sugai Hiroshi, Harada Kazuki, Itoh Kousuke, Uchiumi Toshio, Tanaka Takaaki, Taniguchi Masayuki, Mitsui Toshiaki
66 117 - 117 2014
Fukuda Shun, Ishiyama Yohei, Kondo Hiroshi, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
66 167 - 167 2014
A Differential Equation For Permeation Of Antibody From Blood To The Lung
K. Nakata, K. Akasaka, T. Tanaka, T. Maruyama, R. Tazawa, E. Yamaguchi, T. Ichiwata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 189 2014
Adult-Onset Hereditary Pulmonary Alveolar ProteINOSis Caused By Csf2ra Deletion
R. Tazawa, K. Ito, T. Ogi, H. Ishii, T. Sakagami, Y. Ito, A. Hashimoto, T. Tanaka, K. -I. Akasaka, J. Tohyama, K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 189 2014
骨再生医療のための骨膜培養
田中 孝明
生物工学会誌 : seibutsu-kogaku kaishi 91 ( 3 ) 2013.3
P-220 Structure-function analysis of heat shock protein Hsp 70 from Oryza sativa
Sugai Hiroshi, Ochiai Akihito, Harada Kazuki, Tanaka Takaaki, Taniguchi Masayuki
65 243 - 243 2013
Tajima Koji, Hashimoto Kenji, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
65 164 - 164 2013
Shibata kazuma, Nakamichi Shun-ichi, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
65 164 - 164 2013
Nakamichi Shunichi, Ikeda Atsuo, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
65 163 - 163 2013
Ishiyama Yohei, Shibata Kazuma, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
65 206 - 206 2013
Matsushima Kenta, Matsuhashi Yoshiyasu, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
65 164 - 164 2013
Kondo Hiroshi, Ishiyama Yohei, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
65 164 - 164 2013
チロシナーゼ阻害作用を示す米糠タンパク質由来新規ペプチドの同定と機能解析
落合秋人, 田中聖也, 吉田久志, 田中孝明, 谷口正之
日本農芸化学会大会講演要旨集(Web) 2013 2013
田中孝明, 川瀬知之, 西本崇之, 奥田一博, 永田昌毅, BURNS Douglas M, 吉江弘正
日本膜学会年会講演要旨集 34th 76 2012.4
生分解性プラスチック製多孔質材料の開発 : 多孔質構造の制御と孔を利用した材料の複合化
田中 孝明
プラスチックス : 日本プラスチック工業連盟誌 63 ( 4 ) 58 - 62 2012.4
Ikeda Atsuo, Ishiyama Yohei, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
64 87 - 87 2012
TANAKA Seiya, YOSHIDA Hisashi, OCHIAI Akihito, TANAKA Takaaki, TANIGUCHI Masayuki
64 168 - 168 2012
KONDO Hiroshi, ISHIYAMA yohei, OCHIAI Akihito, TANAKA Takaaki, TANIGUCHI Masayuki
64 168 - 168 2012
Hashimoto Kenji, Takayama Saori, Saito Atsushi, Kato Tetsuo, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
64 88 - 88 2012
Shibata Kazuma, Ishiyama Yohei, Harada Kazuki, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
64 87 - 87 2012
生分解性プラスチック製多孔質膜の開発と応用 (特集 未来材料の創成と実用化)
田中 孝明
ケミカルエンジニヤリング 56 ( 11 ) 817 - 823 2011.11
Development and application of porous membranes of biodegradable plastics
田中 孝明
Fine chemicals 40 ( 8 ) 30 - 36 2011.8
Bioseparation and Bionanotechnology in Japan
田中 孝明
化学工学 = Chemical engineering 75 ( 4 ) 252 - 252 2011.4
Ishiyama Y, Takata T., Nakanishi T., Watanabe N., Kaneko M., Watanabe K., Yanagida F.
60 7 - 8 2011.3
YOSHIDA Hisashi, TOMIYA Tomoyuki, OCHIAI Akihito, TANAKA Takaaki, TANIGUCHI Masayuki
63 148 - 148 2011
HASHIMOTO Kenji, HIGUCHI Yuji, OCHIAI Akihito, TANAKA Takaaki, TANIGUCHI Masayuki
63 184 - 184 2011
Matsuhashi Yoshiyasu, Takayanagi Tomohiro, Takei Norihiro, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
63 148 - 148 2011
Ikeda Atsuo, Takahashi Nobuteru, Takei Norihiro, Hamada Tsutomu, Takagi Masahiro, Ochiai Akihito, Tanaka Takaaki, Taniguchi Masayuki
63 148 - 148 2011
HARADA Kazuki, OCHIAI Akihito, TANAKA Takaaki, TANIGUCHI Masayuki
63 184 - 184 2011
ヒト病原菌に対する米由来抗菌タンパク質の精製とその性質
落合秋人, 原田計, 田中孝明, 谷口正之
生化学 2011
Production of extracellular bifidogenic growth stimulator (BGS) from Propionibacterium shermanii using a bioreactor system with a microfiltration module and an on-line controller for lactic acid concentration
高屋 朋彰, 飛田 和宏, 堀内 將史, 中山 惠理, 出口 央視, 田中 孝明, 谷口 正之
生物工学会誌 : seibutsu-kogaku kaishi 88 ( 2 ) 64 - 64 2010.2
バイオマスプラスチック製濾過膜の開発と応用 (特集 新しいバイオマス利活用技術)
田中 孝明, 高屋 朋彰, 谷口 正之
ケミカルエンジニヤリング 55 ( 2 ) 101 - 107 2010.2
Kouya Tomoaki, Tobita Kazuhiro, Horiuchi Masahiro, Nakayama Eri, Deguchi Hiroyoshi, Tanaka Takaaki, Taniguchi Masayuki
59 7 - 8 2010.2
Membrane preparation and modification
田中 孝明
Membrane 35 ( 1 ) 25 - 28 2010.1
IKEDA Takeichiro, HARADA Kazuki, KUCHIDE Natsuki, KOUYA Tomoaki, OCHIAI Akihito, TANAKA Takaaki, TANIGUCHI Masayuki
22 99 - 99 2010
TANIGUCHI Masayuki, TAKAHASHI Nobuteru, TAKAYANAGI Tomohiro, TAKEI Norihiro, OCHIAI Akihito, TANAKA Takaaki
22 99 - 99 2010
食品微生物を用いた有用生理活性物質の生産
高屋 朋彰, 田中 孝明, 谷口 正之
ニューフードインダストリー 51 ( 11 ) 23 - 33 2009.11
石山洋平, 田中孝明, 谷口正之
ニューフードインダストリー 51 ( 7 ) 8 - 15 2009.7
ISHIYAMA Yohei, KOUYA Tomoaki, KANEOKE Mitsuoki, WATANABE ken-ichi, TANAKA Takaaki, TANIGUCHI Masayuki
21 185 - 185 2009
TAKAHASHI Nobuteru, TAKEI Norihiro, KOISO Yusuke, KOUYA Tomoaki, TAIYOJI Mayumi, OHTSUBO Sadami, TANAKA Takaaki, TANIGUCHI Masayuki
21 185 - 185 2009
ポリ乳酸の多孔質化・複合化による機能性材料の開発
田中 孝明, 谷口 正之
生物工学会誌 : seibutsu-kogaku kaishi 86 ( 7 ) 346 - 348 2008.7
Development of Microfiltration Membranes of Biodegradable Plastics
TANAKA Takaaki
MEMBRANE 33 ( 4 ) 165 - 172 2008.7
モノクローナル抗体の分離精製における分離膜の活用
田中 孝明
化学工学 = CHEMICAL ENGINEERING OF JAPAN 72 ( 5 ) 2008.5
Studies on Membrane Filtration of Food Microbial Cell Suspensions
Tanaka Takaaki
57 7 - 8 2008.3
ISHIYAMA Yohei, TANIGUCHI Masayuki, TAKATA Takeomi, NAKANISHI Toshihiro, KANEOKE Mitsuoki, WATANABE Ken-ichi, YANAGIDA Fujitoshi, CHEN Yi-sheng, KOUYA Tomoaki, TANAKA Takaaki
Japan Journal of Food Engineering 9 ( 4 ) 277 - 286 2008
YOSHIDA Shintaro, KATO Takeshi, SATO Ryota, TANAKA Takaaki, TANIGUCHI Masayuki
20 174 - 174 2008
1Gp07 Ethanol production using rice straw delignified by Pleurotus ostreatus
TAKAHASHI Daisuke, SATO Ryota, TANAKA Takaaki, TANIGUCHI Masayuki
20 174 - 174 2008
KOUYA Tomoaki, KOISO Yusuke, TAIYOJI Mayumi, OHTSUBO Sadami, TANAKA Takaaki, TANIGUCHI Masayuki
20 214 - 214 2008
SAIKAWA Yoko, YAMAZAKI Rika, SHITOMI Yasuyuki, KAWASE Tomokazu, TANAKA Takaaki, TANIGUCHI Masayuki
20 216 - 216 2008
KOISO Yusuke, HIROSE Tomokazu, SHITOMI Yasuyuki, TAIYOJI Mayumi, TANAKA Takaaki, TANIGUCHI Masayuki
20 215 - 215 2008
ISHIYAMA Yohei, TAKATA Takeomi, KOISO Yusuke, KANEOKE Mistuoki, WATANABE Ken-ichi, TANAKA Takaaki, TANIGUCHI Masayuki
20 214 - 214 2008
シリコン薄膜製濾過膜
田中 孝明
化学工学 = CHEMICAL ENGINEERING OF JAPAN 71 ( 11 ) 2007.11
Studies on Membrane Filtration of Food Microbial Cell Suspensions
TANAKA Takaaki
NIHON SHOKUHIN KOUGAKUKAISHI (Japan Journal of Food Engineering) 8 ( 4 ) 221 - 229 2007
Studies on Membrane Filtration of Food Microbial Cell Suspensions
Takaaki Tanaka
NIHON SHOKUHIN KOUGAKUKAISHI (Japan Journal of Food Engineering) 8 ( 4 ) 221 - 229 2007
3S1AM5 50 Development of porous and composite materials of poly(lactic acid)
TANAKA Takaaki, TANIGUCHI Masayuki
19 14 - 14 2007
TAKAHASHI Daisuke, HIGUCHI Yuhki, KATO Takeshi, TANAKA Takaaki, TANIGUCHI Masayuki
19 141 - 141 2007
YOSHIDA Shintaro, KATO Takeshi, HIGUCHI Yuhki, TANAKA Takaaki, TANIGUCHI Masayuki
19 141 - 141 2007
1H11-3 Screening and properties of antimicrobial proteins from rice against Porphyromonas gingivalis
NIWA Yuki, IGARASHI Akira, SHITOMI Yasuyuki, KAWASE Tomokazu, TANAKA Takaaki, TANIGUCHI Masayuki
19 173 - 173 2007
1H10-2 Utilization of rice protein with protease inhibitors as a functional food material
SAIKAWA Yoko, YAMAZAKI Rika, SHITOMI Yasuyuki, KAWASE Tomokazu, TANAKA Takaaki, TANIGUCHI Masayuki
19 172 - 172 2007
KOISO Yusuke, NAKANISHI Toshihiro, TANAKA Takaaki, TANIGUCHI Masayuki
19 171 - 171 2007
1L17-3 Utilization of rice straw delignified by white-rot fungi as substrates for fermentation
HIGUCHI Yuki, KATO Takeshi, WATANABE Daisuke, TANAKA Takaaki, TANIGUCHI Masayuki
18 219 - 219 2006
1J10-1 Production of BGS by aerobic culture of Propionibacterium and analysis of the metabolic shift
DEGUCHI Hiroyoshi, KOYA Tomoaki, NAKAYAMA Eri, TANAKA Takaaki, TANIGUCHI Masayuki
18 171 - 171 2006
3I10-2 Oxydation of natural and synthetic estrogens with laccase
TAMURA Toshiyuki, ISHIZAKI Yuuichi, TANIGUCHI Masayuki, TANAKA Takaaki
18 165 - 165 2006
TAKATA Takeomi, ISHIYAMA Yohei, NAKANISHI Toshihiro, KANEOKE Mitsuoki, WATANABE Ken-iichi, TANAKA Takaaki, TANIGUCHI Masayuki
18 172 - 172 2006
2K10-4 Mechanical properties of porous materials of biodegradable polyesters
AOKI Takashi, EGUCHI Satoko, OGAWA Wataru, TANABE Yuuji, TANIGUCHI Masayuki, LLOYD Douglas R., TANAKA Takaaki
18 200 - 200 2006
イネ由来のプロティナーゼ阻害成分の性質とその食品素材としての利用
五十嵐暁, 川瀬智一, 山崎里佳, 保科昌宏, 大坪貞視, 太養寺真弓, 小林仁, 斎藤英一, 田中孝明, 谷口正之
化学工学会秋季大会研究発表講演要旨集(CD-ROM) 37th F302 2005.9
M Taniguchi, K Kato, O Matsui, Ping, X, H Nakayama, Y Usuki, A Ichimura, K Fujita, T Tanaka, Y Tarui, E Hirasawa
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 100 ( 2 ) 207 - 211 2005.8
新規プロテアーゼ阻害剤オリザシスタチンIIIのクローニングとその組換えタンパク質の性質
五十嵐暁, 保科昌宏, 山崎里佳, 川瀬智一, 田中孝明, 大坪貞視, 小林仁, 野呂渉, 斎藤英一, 谷口正之
日本農芸化学会大会講演要旨集 2005 313 2005.3
田中孝明, 齋藤 浩, 谷口正之
ケミカルエンジニヤリング 50 ( 12 ) 929 - 936 2005
カーボンナノチューブ濾過膜
田中孝明
化学工学 69 ( 1 ) 55 2005
1F16-2 Production and properties of bacteriocins with activity for Hiochi bacteria
NAKANISHI Toshihiro, ISHIYAMA Yohei, KANEOKE Mitsuoki, WATANABE Ken-ichi, TANAKA Takaaki, TANIGUCHI Masayuki
17 172 - 172 2005
NAKAYAMA Eri, KOYA Tomoaki, TANAKA Takaaki, TANIGUCHI Masayuki
17 159 - 159 2005
3E12-2 Production at a low cost of L-lactic acid using defatted rice bran as a raw material
HIGUCHI Yuki, WATANABE Daisuke, TANAKA Takaaki, TANIGUCHI Masayuki
17 162 - 162 2005
バイオテクノロジーを支える濾過技術
田中 孝明
生物工学会誌 : seibutsu-kogaku kaishi 82 ( 9 ) 457 - 457 2004.9
Production of poly(lactic acid) from underutilized biomass
Takaaki Tanaka, Masayuki Taniguchi
31 ( 5 ) 186 - 189 2004.5
Enzymatic oxidative polymerization of 4-chloroguaiacol by laccase (vol 36, pg 1101, 2003)
T Tanaka, M Yamamoto, M Takahashi, T Fujii, M Taniguchi
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 37 ( 3 ) 2004.3
2D13-5 Analysis of action of bifidogenic growth stimulator using co-culture system with membrane
KOYA Tomoaki, NAKAYAMA Eri, TANAKA Takaaki, TANIGUCHI Masayuki
16 155 - 155 2004
2D16-2 Utilization of rice straw delignified by basidiomycetes as a carbon source for fermentation
SUZUKI Hiroyuki, WATANABE Daisuke, TANABE Toshiaki, KUWAHARA Masaaki, TANAKA Takaaki, TANIGUCHI Masayuki
16 158 - 158 2004
WATANABE Daisuke, HOSHINA Masahiro, HIGUCHI yuki, TANAKA Takaaki, TANIGUCHI Masayuki
16 157 - 157 2004
3D11-4 Antimicrobial action of bacteriocin produced by lactic acid bacteria against hiochi-bacteria
ISHIYAMA Yohei, NAKANISHI Toshihiro, KANEOKE Mitsuoki, WATANABE Ken-ichi, TANAKA Takaaki, TANIGUCHI Masayuki
16 162 - 162 2004
Reduction in risk of soil and sediment contamination by endocrine disrupting chemicals using a bioreactor.
Takaaki Tanaka, Masataka Nose, Ayuko Endo, Tomoyuki Fujii, Masayuki Taniguchi
Enviromental Sciences 9 ( 2-3 ) 245 - 245 2002
Tanabe Suguru, Hoshina Masahiro, Sato Kazuhito, Ohtsubo Sadami, Sakai Kenji, Tanaka Takaaki, Taniguchi Masayuki
14 42 - 42 2002
806 Degradation of chlorophenols with laccase and clarification of their degrading pathways
Kando Takamitsu, Wada Naoyuki, Suzuki Hiroyuki, Hoshino Kazuhiro, Tanaka Takaaki, Taniguchi Masayuki
14 144 - 144 2002
Enzymatic remediation of model sediment polluted with endocrine disrupting chemicals using a rotating reactor
Takaaki Tanaka, Takuto Konishi, Takashi Tonosaki, Masataka Nose, Noriko Tomidokoro, Tomoyuki Fujii, Masayuki Taniguchi
Environmental Sciences 8 ( 2-3 ) 299 - 300 2001
Production of lactic acid by simultaneous saccharification and fermentation of rice bran.
Tanabe Takaaki, Ishii Tatsuyuki, Sato Kazuhito, Ohtsubo Sadami, Tanaka Takaaki, Taniguchi Masayuki
13 326 - 326 2001
Wada Naoyuki, Kando takamitsu, Sakurai Hiroyuki, Tanaka Takaaki, Taniguchi Masayuki
13 327 - 327 2001
Ishii Katsuyuki, Ishida Jyunya, Tanabe Suguru, Sakai Kenji, Tanaka Takaaki, Taniguchi Masayuki
13 327 - 327 2001
Production of BGS by propionic acid bacteria under anaerobic and aerobic conditions.
Ishida Jyunya, Sato Nobuyuki, Tsuchiya Tomohiro, Tanaka Takaaki, Taniguchi Masayuki
13 326 - 326 2001
Formation and structural change of cake during crossflow microfiltration of microbial cell suspension containing fine particles
T Tanaka, N Yamagiwa, T Nagano, M Taniguchi, K Nakanishi
BIOSEPARATION ENGINEERING 16 29 - 34 2000
米糠を炭素源とした生分解性ポリマー原料の生産--穀類廃棄物の資源化プロセスの開発
谷口 正之, 田中 孝明, 星野 一宏
年報 2000 279 - 283 2000
米糠を炭素源とした生分解性ポリマー原料の生産--穀類廃棄物の資源化プロセスの開発
谷口 正之, 田中 孝明, 星野 一宏
年報 1999 294 - 299 1999
Taniguchi Masayuki, Yamada Hideto, Tobita Kazuhiro, Kaneko Tsutomu, Tanaka Takaaki
11 369 - 369 1999
Degradation of estrogen related compounds by oxidascs from basidiomycetes.
Tonosaki T., Kadomura N., Yamada K., Goto H., Taniguchi M., Tanaka T.
11 304 - 304 1999
Degradation of dialkyl phthalates by lipase
Konishi Takuto, Takahashi Masafumi, Tanaka Takaaki
11 312 - 312 1999
Degradation bebavior of PCP by basidiomycetes in solid state fermentation system.
Matsushita Kazunori, Sakurai Hiroyuki, Goto Hideyuki, Tanaka Takaaki, Taniguchi Masayuki
11 305 - 305 1999
Enzymatic polymerization of aromatic compounds in media containing organic solvents.
Usui Hisaki, Mogi Hiroyuki, Nudejima Shin-ichi, Taniguchi Masayuki, Tanaka Takaaki
11 176 - 176 1999
Production of lactic acid from a mixed sugar solution by co-culture of lactic acid bacteria.
Tokunaga Takashi, Horiuchi Ken-ichiro, Tanaka Takaaki, Taniguchi Masayuki
11 226 - 226 1999
細胞固定化用アルギン酸ゲルの改良
田中 孝明
生物工学会誌 76 ( 9 ) 400 - 400 1998.9
Biodegradation of alkylphenols (endocrine disruptors) by lignin degrading enzymes of basidiomycetes.
Yamada Kiyoshi, Tonosaki Takashi, Konishi Takuto, Taniguchi Masayuki, Tanaka Takaaki
10 58 - 58 1998
Production of BGS with P.freudenreichii subsp. shermanii.
Shiraishi Norio, Tobita Kazuhiro, Satoh Nobuyuki, Kaneko Tsutomu, Umezawa Akira, Tanaka Takaaki, Taniguchi Masayuki
10 216 - 216 1998
Production of bifidus by using a co- culture system with membranes.
Yamada Hideto, Tobita Kazuhiro, Hashimoto Katsuo, Kaneko Tsutomu, Tanaka Takaaki, Taniguchi Masayuki
10 216 - 216 1998
担子菌によるリグニン分解酵素の生産
田中 孝明
生物工学会誌 75 ( 6 ) 447 - 447 1997.11
Tobita Kazuhiro, Horiuchi Masahito, Shiraishi Norio, Kaneko Tsutomu, Umezawa Akira, Tanaka Takaaki, Taniguchi Masayuki
9 93 - 93 1997
Saitoh Ryuji, Ogawa Akihiro, Matsushima Chieko, Tanaka Takaaki, Taniguchi Masayuki
9 239 - 239 1997
Fouling of Membranes used in Food Industry and Its Cleaning
NAKANISHI Kazuhiro, TANAKA Takaaki, SAKIYAMA Takaharu
MEMBRANE 21 ( 2 ) 86 - 94 1996.3
Degradation of persistent dyes with basidiomycetes.
Ogawa Akihiro, Saito Ryuji, Tanaka Takaaki, Taniguchi Masayuki
8 237 - 237 1996
Production of kojic acid by Membrane-surface liquid culture with medium recycle.
Wakisaka Yasusi, Ogawa Akinori, Asai Hironobu, Tanaka Takaaki, Sakiyama Takaharu, Nakanisi Kazuhiro
7 173 - 173 1995
Enzymatic synthesis of aspartame precursor in organic solvents.
Miyanaga Masamitsu, Ohmori Michihiro, Tanaka Takaaki, Sakiyama Takaharu, Nakanishi Kazuhiro
7 135 - 135 1995
クロスフロ-濾過法による菌体分離操作
中西 一弘, 田中 孝明
日本食品工業学会誌 41 ( 8 ) p578 - 584 1994.8
CROSS-FLOW FILTRATION OF MICROBIAL SUSPENSION
K NAKANISHI, T TANAKA
JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI 41 ( 8 ) 578 - 584 1994
Purification and properties of monoglyceride lipase from Pseudomonas LP7315
Miyake Akira, Taguchi Rieko, Tanaka Takaaki, Sakiyama Takaharu, Nakanishi Kazuhiro, Ozaki Akira, Tanaka Atsushi
6 75 - 75 1994
Production of kojic acid by the Membrane-Surface Liquid Culture of Mold.
Wakisaka Yasusi, Ogawa Akinori, Tanaka Takaaki, Sakiyama Takaharu, Nakanisi Kazuhiro
6 255 - 255 1994
Crossflow filtration of rod-shaped cells
Tanaka Takaaki, Abe Takaaki, Kouda Kenji, Nakanisi Kazuhiro
6 256 - 256 1994
Factors affecting the synthetic reaction of dextran using dextransucrase
Sunahara Shinji, Takata Hajime, Matsumoto Shinji, Tanaka Takaaki, Sakiyama Takaharu, Nakanishi Kazuhiro
6 89 - 89 1994
微生物菌体培養液のクロスフロ-濾過 (最近の膜分離技術の応用と進展<特集>)
中西 一弘, 田中 孝明
ケミカルエンジニヤリング 38 ( 11 ) p905 - 910 1993.11
Enzymatic syntehesis of Asparateme precursor in organic solvents.
Miyanaga masamitsu, Susuki keiji, Nagayas takeshi, Tanaka takaaki, Nakanishi kazuhiro
5 118 - 118 1993
Enzymatic synthesis of oligopeptides in organic solvents.
Nagayasu Takeshi, Shinnai Toshihiko, Tanaka Takaaki, Nakanishi Kazuhiro
4 120 - 120 1992
Crossflow filtration of dextran broth
Tanaka Takaaki, Okabe Hiroyuki, Nakanishi Kazuhiro
4 149 - 149 1992
有機溶媒中での呈味性オリゴペプチドの酵素合成 (化工手法による合成技術<特集>)
田中 孝明, 富田 憲史, 中西 一弘
ケミカルエンジニヤリング 36 ( 10 ) p898 - 903 1991.10
バイオプロセスにおける膜分離法の諸問題 (生物機能の応用とバイオセパレ-ション<特集>)
中西 一弘, 田中 孝明
ケミカルエンジニヤリング 36 ( 6 ) p462 - 467 1991.6
食品工業における洗浄の工学的諸問題 (食品化学工学の新展開<特集>)
中西 一弘, 田中 孝明
ケミカルエンジニヤリング 36 ( 4 ) p290 - 294 1991.4
Continuous Peptide Syntheses with Immobilized Enzymes in Organic Solvent
Nakanishi Kazuhiro, Tanaka Takaaki, Kimura Yukitaka, Matsuno Ryuichi
2 39 - 39 1990
Studies on Leu-Lys-specific Peptidases Produced by Get-entrapped Yeast Cells.
Tanaka Takaaki, Okada Tsutomu, Sonomoto Kenji, Tanaka Atsuo
63 48 - 48 1988
Production of L-Serine from Glycine by Immobilized Growing Corynebacterium glycinophilum Cells
Tanaka Takaaki, Yamamoto Keiichi, Nakajima Hiroki, Sonomoto Kenji, Tanaka Atsuo, Yokozeki Kenzo, Kubota Koji
62 33 - 33 1987
再生治療用低分解性フィブリンゲル膜の製造方法及びその製造装置
山内 慶次郎, 阿部 和幸, 川瀬 知之, 田中 孝明
再生治療用低分解性フィブリンゲル膜の製造方法及びその製造装置
山内 慶次郎, 阿部 和幸, 川瀬 知之, 田中 孝明
山内 慶次郎, 阿部 和幸, 川瀬 知之, 田中 孝明
山内 慶次郎, 阿部 和幸, 川瀬 知之, 田中 孝明
田中 孝明
田中 孝明
田中 孝明
田中 孝明
田中 孝明
田中 孝明
田中 孝明
田中 孝明
田中 孝明
Outstanding Paper Award, Membrane
2021.6 Preparation of polyhydroxyalkanoate microfiltration membranes via nonsolvent–induced phase separation methods
Kazuyoshi Tabata, Toshiki Shibuya, Kousuke Karakida, Akihito Ochiai, Masayuki Taniguchi, Takaaki Tanaka
The 25th Paper Award of The Society for Biotechnology, Japan
2017.9 The Society for Biotechnology, Japan AmyI-1–18, a cationic α-helical antimicrobial octadecapeptide derived from α-amylase in rice, inhibits the translation and folding processes in a protein synthesis system
TANAKA Takaaki
Outstanding Paper Award of MEMBRANE
2017.5 The Membrane Society of Japan Preparation of a poly(L-lactic acid) membrane scaffold with open finger-like pores prepared by a nonsolvent-induced phase separation method with the aid of a surfactant
H. Minbu, T. Kawase, A. Ochiai, M. Taniguchi, T. Tanaka
Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemisry in 2014
2015.3 The Japan Society for Bioscience, Biotechnology, and Agrochemistry Crystal structure of α-amylase from Oryza sativa: molecular insights into enzyme activity and thermostability
Akihito Ochiai, Hiroshi Sugai, Kazuki Harada, Seiya Tanaka, Yohei Ishiyama, Kosuke Ito, Takaaki Tanaka, Toshio Uchiumi, Masayuki Taniguchi, Toshiaki Mitsui
Paper Award
2010.8 Japan Society for Food Engineering Growth-inhibition of Lactobacillus hilgardii, a bacterium related to hiochi, in the mizu-koji process by bacteriocins from lactic acid bacteria
Y. Ishiyama, T. Takata, T. Nakanishi, M. Kaneoke, K. Watanabe, F. Yanagida, Y. Chen, T. Kouya, T. Tanaka, M. Taniguchi
The 17th Paper Award of The Society for Biotechnology, Japan
2009.9 The Society for Biotechnology, Japan Production of extracellular bifidogenic growth stimulator (BGS) from Propionibacterium shermanii using a bioreactor system with a microfiltration module and an on-line controller for lactic acid concentration
T. Kouya, K. Tobita, M. Horiuchi, E. Nakayama, H. Deguchi, T. Tanaka, M. Taniguchi
Encouragement Award of Japan Society for Food Engineering
2007.8 Japan Society for Food Engineering Studies on Membrane Filtration of Food Microbial Cell Suspensions
Takaaki Tanaka
アスリートの選手生命を救うPRP治療の確立に向けた基盤的研究
Grant number:22K11496
2022.4 - 2025.3
System name:科学研究費助成事業
Research category:基盤研究(C)
Awarding organization:日本学術振興会
牛木 隆志, 望月 友晴, 川瀬 知之, 田中 孝明
Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )
Development of mixed-mode monolith-type adsorption materials and their application to purification process of proteins and peptides
Grant number:17K06921
2017.4 - 2020.3
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
Tanaka Takaaki
Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )
In this study mixed-mode monolith-type adsorption materials were developed to be used in separation and purification of proteins and peptides in biopharmaceuticals production. Porous monoliths were prepared from polymers (poly(methyl methacrylate) and poly(lactic acid)) via phase separation methods. Hydroxyapatite particles that have mixed-mode (multimodal) type adsorption property were mainly composited with the monoliths. The prepared monoliths have adsorption abilities toward model proteins. For example, bovine serum albumin and bovine gamma-globulin were separated by one of the developed monoliths.
Developments of scaffolds and processing technology to maximize the osteogenic potential of cultured periosteal sheets
Grant number:24390443
2012.4 - 2016.3
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (B)
Awarding organization:Japan Society for the Promotion of Science
Kawase Tomoyuki, OKUDA KAZUHIRO, NAGATA MASAKI, TANAKA TAKAAKI
Grant amount:\18460000 ( Direct Cost: \14200000 、 Indirect Cost:\4260000 )
The purpose of this project is to demonstrate ideal structure and stiffness of scaffolds for osteogenic cells and to develop ideal scaffolds with biodegradable polymer materials. Under regular culture conditions, human periosteal cells (PC) expressed integrin α1β1 and CD44 as major adhesion molecules. Atomospheric plasma treatment modified the titanium surface and facilitated their osteoblastic differentiation. We also found that human platelet-rich fibrin (PRF) extract can be substituted for FBS. As for scaffolding materials, we developed a combinational porous membrane made of polycaprolactone and hydroxyapatite and found its stiffness and microstructure appropriate for PCs.
Control of the internal and surface structures of biodegradable porous membranes with the aid of surfactants and their application to bioprocess
Grant number:24560957
2012.4 - 2016.3
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
TANAKA Takaaki, KAWASE Tomoyuki
Grant amount:\5330000 ( Direct Cost: \4100000 、 Indirect Cost:\1230000 )
Biodegradable separation membrane and scaffold materials have been developed by controlling their internal and surface structures with the aid of surfactants. Asymmetric microporous separation membranes of poly(L-lactic acid) with pores in the order of 0.1 μm were prepared from the polymer solutions containing surfactants with the hydrophilic-lipophilic balance (HLB) values from 15.3 to 16.7. Osteoblast-like cells grew in the 500 μm-thick biodegradable microporous membranes when the cells were seeded on the rough side of the membranes.
Control of composition and morphology of hollow hydroxyapatite microspheres and their application to dental implant materials releasing an antimicrobial agent
Grant number:21560712
2009 - 2011
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
KIMURA Isao, KANATANI Mitsugu, TANAKA Takaaki, AKAZAWA Toshiyuki
Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )
Hollow microspheres of calcium phosphate compounds(such as hydroxyapatite, calcium hydrogen phosphate, etc.) were prepared by using multiple emulsions. The composition, morphology, and crystallinity were controlled by the addition of one of a magnesium salt, a carbonate, and low molecular weight organic compounds. For obtaining fundamental knowledge to apply the microspheres to dental implants which release an antimicrobial agent, the conditions for making them adhere onto titanium were investigated. A model implant was fabricated through the following procedures : the formation of microsphere layers on the surface of a titanium screw, the impregnation of a dye solution as the model material of an antimicrobial agent into the microsphere layer, and the coating with biodegradable polymer, poly(lactic acid). With the aim of applying the microspheres to a root canal treatment, composite microcapsules of the microspheres with biodegradable polymer were prepared.
Development of environmental-benign bioseparation membranes by hybridizing biodegradable porous materials and nano inorganic microcapsules
Grant number:21560807
2009 - 2011
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
TANAKA Takaaki, KIMURA Isao
Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )
Environmentally benign separation membranes have developed by hybridizing microporous membranes of biodegradable plastics and hydroxyapatite nanoparticles. The depth filter microfiltration membranes of poly(L-lactic acid) developed by Dr. Tanaka, the head of the research project, retained the microcapsules comprised of hydroxyapatite nanoparticles developed by Dr. Kimura, the co-researcher. The hybrid membrane of the biodegradable membrane and hydroxyapatite microcapsules adsorbed bovine serum albumin, a model protein, at a low ionic strength and eluted at an elevated ionic strength.
Control of internal structure of porous membranes of biodegradable polymer blends and its application to bioprocesses
Grant number:18560748
2006 - 2008
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
TANAKA Takaaki, TANIGUCHI Masayuki
Grant amount:\3740000 ( Direct Cost: \3200000 、 Indirect Cost:\540000 )
Acceleration of bone formation on mandibular distraction osteogenesis
Grant number:18592169
2006 - 2008
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
KOBAYASHI Tadaharu, TANAKA Takaaki, IZUMI Naoya, EJIRI Sadakazu
Grant amount:\4160000 ( Direct Cost: \3500000 、 Indirect Cost:\660000 )
Development of porous membranes of poly (lactic acid) via thermally induced phase separation and its application to bioprocesses
Grant number:15560673
2003 - 2005
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
TANAKA Takaaki, TANIGUCHI Masayuki, AOKI Toshiki, MATSUYMA Hideto
Grant amount:\3600000 ( Direct Cost: \3600000 )
Biodegradable polyesters, e.g., poly(_L-lactic acid), which are degraded by microorganisms in natural environment and degradable in human bodies, have recently received increased attention in bioengineering. In this study we have developed microporous membranes of biodegradable polyesters via thermally induced phase separation. At first effect of characteristics of polymers and conditions of phase separation (diluent, polymer concentration, and thermal history) on the growth of the droplet in phase separation and the structures and pore sizes of the formed porous materials. Then, we made microporous membranes of poly(_L-lactic acid), poly(ε-caprolactone), and their blends. The poly(_L-lactic acid) membrane showed the characteristics of a screen filter in the filtration of yeast cell suspensions. The membrane of a polymer blend of poly(_L-lactic acid) and poly(ε-caprolactone) showed that of a depth filter. The filtration flux with the latter membrane was much higher than that with the former. We also applied poly(_L-lactic acid) membrane to the production of an oxidase, laccase, by membrane-surface liquid culture of white rot fungus, Trametes versicolor. The membrane was stable at 28℃ and the fungus grown on the membrane secreted much more enzyme in the repeated use of membrane-surface liquid culture than in liquid surface culture. The porous biodegradable membranes would contribute to the development of sustainable bioindustry and biomedical engineering.
生分解性高分子の応用
2002
Grant type:Competitive
Formation and application of microporous biodegradable polyester membranes
2002
Grant type:Competitive
Mechanism and Optimization of Diffusion controlled enantioselective permeable membrane
Grant number:13555213
2001 - 2003
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (B)
Awarding organization:Japan Society for the Promotion of Science
AOKI Toshiki, TACHIBANA Kozo, KANEKO Takashi, TANAKA Takaaki
Grant amount:\7200000 ( Direct Cost: \7200000 )
We have synthesized new well-defined polymers and developed optical resolution membranes which have high enantioselevtivity from these polymers. We proposed the separations occurred in diffusion process. However, the reason and detail were not clear and their permeation rates were low. In this study, several optimizations were carried out in these membrane process. For example, molecular structures, conditions in membrane preparation and permeation were examined.
First, several new optically active polymers were synthesized. Especially, we have discovered new polymerization method to obtain chiral helical polymers. In addition, new chiral helical polymers were prepared by condensation polymerization.
Secondly, we confirmed the separation of these membrane process occurred in diffusion process. In addition, chiral helicity was found to be effective for enantioselective permeation. In particular, we found that polymeric membranes whose chiral groups had been removed by reaction in membrane state showed enantioselective permeability.
Lastly, thin membranes such as composite membranes and asymmetric membranes were prepared. High permeation was realized by using these thin membranes. Pervaporation was also tried to make the rate higher.
In conclusion, we attained higher permeability and obtained many findings for practical use.
Conversion of Agricultural Wastes to Lactic Acid by a Combination of Pentose-fermentative Lactic Acid Bacteria and Reversibly Soluble-insoluble Enzymes
Grant number:13836003
2001 - 2002
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
TANIGUCHI Masayuki, TANAKA Takaaki
Grant amount:\3600000 ( Direct Cost: \3600000 )
1) Glucose and xylose were mainly obtained from delignified rice straw by hydrolysis using cellulase preparation. Glucose and arabinose were mainly obtained from defatted rice bran by hydrolysis using amylase and cellulase preparations.
2) Lactobacillus vaccinostericus, Lactobacillus pentosus, Pediococcus pentosaceus, and Enterococcus casseliflavus were selected as a xylose-fermented lactic acid bacterium. More lactic acid was produced from MRS medium containing xylose by E. casseliflavus as compared with other lactic acid bacteria.
3) The amount of lactic acid produced did not increase in a fermentation using MRS medium containing xylose and glucose as a carbon source and E. casseliflavus.
4) The maintenance of pH at a low value in a simultaneous saccharification and fermentation of non-sterilized rice bran allowed the selective growth of Lactobacillus rhamnosus, a lactic acid bacterium added. About 30 g/L of L-lactic acid was produced from defatted rice bran in a simultaneous saccharification and fermentation in which the pH was kept at 4.5.
Development of Nanobiore actor for Remediation of Foods and Environments
Grant number:13558072
2001 - 2002
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (B)
Awarding organization:Japan Society for the Promotion of Science
FUJII Tomoyuki, MIYAWAKI Osato, MIYAKE Noriko, HATTORI Yoshio, TANAKA Takaaki
Grant amount:\6900000 ( Direct Cost: \6900000 )
A thin nanoporous silica membrane was prepared by the two-step sol-gel method for the purpose that the generation of an aggregate having the higher fractal dimension was suppressed in the intermediate process. It succeeded in the preparation of the thin silica film with nanospace of about 3.3nm. The model reaction in which sea sand was made to adsorb the alkylphenol was carried out, and it was found that adsorbing nonylphenol and octylphenol and bisphenol A are quickly decomposed by laccase. The decomposition of an artificial estrogen also confirmed being possible. Log P, which was an useful parameter when we evaluate the solvent property of supercritical carbon dioxide, was estimated. As the pressure of carbon dioxide was increase on the pressure of 3.0 11.8 MPa, log P tended to increase from 0.9 to 2.0. It was shown that the polarity had appeared in carbon dioxide under the supercritical state by the pressure, and that the polarity became small with the increase in the pressure. On the esterification reaction between stearic acid and ethanol using lipase, the reaction rate rose with the increase in the pressure, and it agreed with the increase tendency of log P approximately. It was shown from these results that the solvent property as a bulk had to be considered in addition to the interaction between solute and carbon dioxide, enzyme surface, wall surface, respectively, when it examined the enzyme reaction in nanospace by using supercritical carbon dioxide as a solvent.
生体触媒を用いた内分泌攪乱化学物質分解システムの開発
Grant number:12750698
2000 - 2001
System name:科学研究費助成事業
Research category:奨励研究(A)
Awarding organization:日本学術振興会
田中 孝明
Grant amount:\1800000 ( Direct Cost: \1800000 )
平成12年度に引き続き,生体触媒による内分泌撹乱化学物質の分解処理システム(バイオレメディエーション・システム)の研究を進めた。平成12年度に開発した回転型バイオリアクターを用いて,砂質に付着したノニルフェノールの分解を行い,反応条件の検討とリスク削減の検証を行った。生体触媒としては白色腐朽菌Trametes sp.由来のラッカーゼを用い,モデル汚染底質としてノニルフェノールを付着させた海砂を用いた。反応装置としては5x5x6cmの正方柱型の反応容器内でモデル汚染底質を回転させる,回転型リアクターを用いた。リアクター中にて,主としてpH5, 30℃にて,15gのモデル汚染底質を酵素溶液45mlを用いて処理した。まず,リアクターの回転軸の角度が反応速度に与える影響について検討した。40-90度の範囲では角度を小さくすると処理速度が高くなったため,40度が最適であった。回転速度については0-45rpmの範囲では10rpmが最適であり,10rpm以上では,回転に要する動力は高くなるが,処理速度は高くならなかった。この傾向は酵素液量を変化させたときも同じであった。次に酵素濃度を変化させて処理反応を行ったところ,反応速度は酵素濃度の約1/2乗に比例してしか増加しなかった。砂粒子の表面上のノニルフェノールに対しては,酵素濃度を高めても酵素濃度当りの作用効率が低下すると考えられた。反応温度を高めると40℃までは反応速度が高められた。ただし,10℃においても反応時間を長くすると90%以上の処理が可能なことが示された。最後に,オスメダカを用いた暴露実験にて,処理後の砂質からの抽出物の毒性評価を,血中ビテロゲニン濃度を指標として行った。その結果,ラッカーゼ処理によりノニルフェノールの内分泌撹乱作用が大きく低下することが示された。
白色腐朽菌のリグニン分解酵素を用いた酸化重合反応による新規性分解性ポリマーの合成
Grant number:11875175
1999
System name:科学研究費助成事業
Research category:萌芽的研究
Awarding organization:日本学術振興会
谷口 正之, 田中 孝明
Grant amount:\2100000 ( Direct Cost: \2100000 )
本研究では,ラッカーゼを用いてフェノール類から生分解性ポリマーを合成することについて検討した。この研究において、以下の結果を得た。
1)バイオリアクターを用いてCoriolus versicolorによるラッカーゼの効率的生産について検討した結果、固体培地の初期水分含量を70%とした培養14日目に最大酵素活性が得られた。
2)固体培地から回収したラッカーゼを,硫安沈殿で濃縮した後、イオン交換クロマトグラフィーと疎水性クロマトグラフィーによって精製した結果、比活性が45倍となった高純度の酵素を得ることができた。
3)精製したラッカーゼを用いて、フェノールおよびフェニルフェノールを基質モノマーとして重合反応を行った結果、いずれもpHが4.5のときにポリマーの収率が最大となった。
4)フェニルフェノールを基質モノマーとして用いた場合には、反応溶媒にアセトンを添加することによってポリマー収率が向上した。アセトンを30%添加したときのポリマー収率は98%であった。
5)フェノールを基質モノマーとして重合反応を行った場合に生成したポリマーは、ジメチルホルムアミドに溶解しない高分子量であった。一方、フェニルフェノールを重合した場合に生成したポリマーは、ジメチルホルムアミドに溶解し、その分子量は6,000-10,000であった。
6)フェノールおよびフェニルフェノールの酵素酸化重合物の熱重量分析を行った結果、これらの重合物は340℃まで安定であった。
Production of Bifidogenic Growth Stimulator and Its Application to Development of Probiotics
Grant number:10555286
1998 - 2000
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (B).
Awarding organization:Japan Society for the Promotion of Science
TANIGUCHI Masayuki, TANAKA Takaaki, IIDA Takamitsu, HOSHINO Kazuhiro, HOJO Kenichi, KANEKO Tsutomu
Grant amount:\12700000 ( Direct Cost: \12700000 )
1. The concentration and the productivity per time of bifidogenic growth stimulator were increased by using a co-culture system for a homolactic acid bacterium and a propionic acid bacterium, a culture system with microfiltration, a fed-batch culture system with feed back control of carbon source concentration, and a culture system with microfiltration and feed back control of carbon source concentration.
2. A novel bioreactor system with two fermentors and microfiltration modules was developed for efficient production bifidobacterial cells by a co-culture of Propionibacterium freudenreichii and Bifidobacterium adolescentis as well as clarification of interactions between the two bacteria.
3. The proposed co-culture system allowed the successful exchange of culture medium between two fermentors. When P.freudenreichii and B.adolescentis, B.longum, or B.breve were cultivated individually in the new co-culture system, the amount of bifidobacterial cells produced was 1.2-1.6 fold as high as that with batch culture.
残留農薬迅速分解のための固定化リグニン分解酵素バイオリアクターシステムの開発
Grant number:09750869
1997 - 1998
System name:科学研究費助成事業
Research category:奨励研究(A)
Awarding organization:日本学術振興会
田中 孝明
Grant amount:\2100000 ( Direct Cost: \2100000 )
リグニン分解酵素を用いた残留農薬の迅速分解を行うためのバイオリアクターシステムの開発を目的として、その基礎となる研究を行った。まず、酵素の生産条件を検討した。リグニン分解酵素生産菌としては4種類の担子菌(Corilus versicolor ,Pleurotus osteatus,Phanerochaete chrysosporium,Bjerkandera adusta)を用いた。固体培養と液体培養とでリグニン分解酵素(リグニンペルオキシダーゼ、マンガンペルオキシダーゼ、ラッカーゼ)の培養体積当たりの生産量を比較したところ、固体培養の酵素生産量が液体培養の場合と比較して10から100倍程度高かった。次に、固体培養の菌体外酵素液を用いて農薬の一種ペンタクロロフェノールの分解実験を行った。酵素としては主としてC.versicolorの菌体外酵素を用いた。0.1-1.0mMのペンタクロロフェノール溶液(10%メタノール含有)に酵素液を添加したところ、7日間で80%分解された。各種農薬の水への溶解度を検討したところ、極めて低かった。そこで河川底質に残留する農薬の酵素分解を検討した。汚染底質のモデル系として海砂にアルキルフェノールを吸着させたものを用いた。アルキルフェノールは多くの農薬と同じく疎水性であり、近年、一部の農薬と同様に内分泌撹乱化学物質として環境中での毒性が懸念されている。C.versicolorの菌体外酵素液でアルキルフェノールは分解された。また、酵素分解の至適pHは5であった。また、C.versicolorの菌体外酵素液から精製したラッカーゼでも海砂に吸着したアルキルフェノールが分解できた。ラッカーゼは反応に酸素を要求することから、汚染底質を撹拌しながら分解反応を行うバイオリアクターについて考察した。
リグニン分解酵素の応用
1996
Grant type:Competitive
Application of lignin degrading enzymes
1996
Grant type:Competitive
DEVELOPMENT OF BIOREACTOR SYSTEM FOR OLIGOPEPTIDE SYNTHESIS COMBINED WITH A SIMULATED MOVING BED ADSORBER
Grant number:07555563
1995 - 1996
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (A)
Awarding organization:Japan Society for the Promotion of Science
NAKANISHI Kazuhiro, SHIOTA Katashi, UTAGAWA Takashi, SIRAI Yoshihito, TANAKA Takaaki, SAKIYAMA Takaharu
Grant amount:\1700000 ( Direct Cost: \1700000 )
In this study, we aimed to construct an effective bioreactor for synthesis of aspartame precursor, as a model oligopeptide in an organic solvent, using thermolysin immobilized onto Amberlite XAD-7. First, we investigated the factors affecting the synthesis of the asparatme precursor using an immobilized enzyme. We studied a synthetic rate, particularly in a mixed organic solvent with ethyl acetate and tert-amyl alcohol. Using a mixed solvent of 33% tert-amyl alcohol and 67% ethyl acetate, the activity and stability of the immobilized thermolysin were high enough to conduct a continuous reaction. With increasing the content of tert-amyl alcohol, the stability of the immobilized enzyme was enhanced. The reason for the high activity and stability of the immobilized thermolysin in the presence of tert-amyl alcohol was studied from the viepoint of stability of calcium bound on the enzyme molecule, a stabilizing factor for thermolysin. An optimum water content for the synthesis of asparatame precursor was found to be 4-6 % in the mixed organic solvent. The concentration of L-phenyllalanine methyl ester (PheOMe) and N- (benzy loxy carbonyl) -L-as partic acid (Z-Asp) was optimized. The concentration of PheOMe was set to 200 mM and that of Z-Asp was 40 mM.We could also conduct a continuous reaction in a column reactor at 40゚C.The conversion at the outlet of the reactor with respect of Z-Asp was around 99% with a space velocity of 4.9 (1/h). Based on this result, we aimed to develop a bioreactor system combined with a simulated moving bed absorber. Namely, at the outlet of the bioreactor, the Z-Asp concentration was negligible low with asparatame precursor Z-Asp PheOMe of around 40 mM and PheOMe of 160 mM.Thus, we could recycle PheOMe to the bioreactor with continuous separation of PheOMe and Z-AspPheOMe using a simulated mooving bed adsorber. We found Dowex MWA-1 as a suitable adsorbent and analyzed adsorption/desorption behaviors of PheOMe and Z-AspPheOMe. We also calculated a separation performance for a simulated moving bed adosorber. We also showed a possible bioreactor system which could be used for an industrial production. Finally, we briefly compared an enzymatic synthesis and chemical synthesis.
食品加工プロセスにおける汚れの洗浄過程の解析とその効率化
Grant number:06650859
1994
System name:科学研究費助成事業
Research category:一般研究(C)
Awarding organization:日本学術振興会
中西 一弘, 田中 孝明, 崎山 高明
Grant amount:\2000000 ( Direct Cost: \2000000 )
食品製造工程やバイオプロセスにおいては、必ず装置表面に付着残存する汚れ成分を除去するための洗浄操作が実施されている。本研究では、洗浄操作の最適化を最終目的として、その基礎となる溶質のステンレス表面への付着・脱離現象の解明を行った。モデル汚れ成分として、β-ラクトグロブリンを取り上げた。溶質の付着特性と洗浄特性を精度よく調べるために、比表面積の大きなステンレス微粒子を用いた。タンパク質の付着量に及ぼす、付着時間、pH、温度、蛋白濃度の影響を調べた。温度が50℃以下では、その最大付着量は単分子層が形成される量にほぼ一致したが、β-ラクトグロブリンの変性温度である65℃前後から急激に増加し、単分子層の数倍程度となった。付着量はpHに強く依存した。β-ラクトグロブリンの等電点である5.1以下では付着量は急激に増加したが、これは負に帯電しているステンレス表面と正に帯電しているタンパク質との間の静電的相互作用によるものであることが判明した。また、未変性タンパク、予め変性したタンパク、及びSH基を修飾したタンパク質を用いて吸着実験を行った結果、β-ラクトグロブリンは、静電気的相互作用、及び疎水結合によりステンレス表面に付着し、その後タンパク質間でS-S結合の形成や交換反応により付着が進行することが明らかになった。
洗浄特性に関しては、申請者らが開発した汚れの付着したステンレス粒子充填カラムを用いるステップ応答法を用いた。アルカリ洗浄と、プロテアーゼを用いる酵素洗浄に着目して比較検討した。酵素法では、アルカリ洗浄に比較してより低いpHで、洗浄が可能であり、しかも残存付着量も少ないことが判明した。また、アルカリ洗浄ではタンパク分子、あるいはその凝集体の形で、一方、酵素洗浄では分解ペプチドの形で、表面から脱離することが示唆された。
培地由来の微粒子を含む培養液のクロスフロー膜濾過に関する基礎的研究
Grant number:05750719
1993
System name:科学研究費助成事業
Research category:奨励研究(A)
Awarding organization:日本学術振興会
田中 孝明
Grant amount:\800000 ( Direct Cost: \800000 )
本研究は微粒子を含む培地で培養した菌体培養液のクロスフロー濾過特性を明らかにすることを目的として行った。平成5年度に得られた研究成果を以下に示す。
(1)微粒子が混入した糖蜜を培地成分としてパン酵素を培養した培養液をクロスフロー濾過したときの濾過速度の変化を濾過期間を菌体層形成過程と微粒子層形成過程に分けることにより予測できることを示した。走査電子顕微鏡観察により微粒子の堆積を実証できた。クロスフロー速度、圧力などを変化させたときに濾過特性がどのように変化するかについてもまとめることができた。特にクロスフロー速度を高めた場合、通常の粒子懸濁液のクロスフロー濾過においては濾過速度が高くなるのに対して、微粒子混入系においては濾過速度が低下することを発見し、上述の2段階付着層形成過程モデルによりも導けることを示した。さらに逆洗を組み合わせたときの操作条件の最適化についてもまとめた。これらの結果は、国際食品工学会議(平成5年6月、千葉)、化学工学会秋季大会(平成5年10月、京都)にて発表した。
(2)微粒子を含む培養液のモデル系として粒径の異なる高分子ラテックスを合成し、その濾過特性を調べた。デッドエンド型濾過特性およびクロスフロー濾過特性を調べた。これと菌体の濾過特性を組み合わせてクロスフロー濾過における濾過速度の粒径依存性についてまとめた。さらに菌体とラテックスの混合懸濁液を調製しクロスフロー濾過特性を検討した。
微生物菌体分離のためのクロスフロー瀘過法の高効率化
Grant number:04203223
1992
System name:科学研究費助成事業
Research category:重点領域研究
Awarding organization:日本学術振興会
中西 一弘, 田中 孝明, 富田 憲史
Grant amount:\2500000 ( Direct Cost: \2500000 )
バイオプロセスにおける除菌・集菌工程の効率化を目的として、クロスフロー膜瀘(Cross Flow Filtration;CFF)に着目して、その膜瀘過流束に及ぼす諸因子の解明を行うと共に、膜透過流束を高くするための方策を検討した。具体例として、(1)パン酵母培養液と、(2)プルラン培養液のCFFを取り上げた。
YPD培地で純粋培養したパン酵母培養液のCFFにおいては、定常流束だけではなく、定常状態に達するまでの流束変化も瀘過理論から推測される結果と一致した。すなわち、クロスフロー膜瀘過時におけるケーク層の充填状態はデッドエンド型瀘過の場合と同様であることが判明した。膜透過流束に及ぼす膜間圧力差、循環流速、菌体濃度、膜の種類などの影響を調べた。循環流速と菌体濃度に関しては、モジュール内部が菌体により閉塞を起こす限界の値が存在することが判明した。
天然培地であるモラッセスを用いて培養を行った場合の膜透過流束は、YPD培地で培養したパン酵母懸濁液の結果と比較して著しく低下した。この理由として、モラッセス中に存在する微粒子が菌体ケーク層表面上に薄い層をなして積もり、しかもこの薄層の比抵抗が菌体ケーク層よりも著しく高いことが明らかにされた。膜透過流束を高めるための方策を検討したところ、逆洗が最も効果的であった。逆洗による膜透過流束の回復は膜孔径に依存し、膜孔径が0.8μm以下の膜では殆どみられず、孔径が3μmあるいは5μmの膜では膜透過流束の回復は100%であった。逆洗を行うことにより、膜透過流束は5倍以上増加した。
プルラン培養液のクロスフロー瀘過においては、菌体の形状が膜透過流束に大きく影響することが判明した。培養条件を工夫することにより膜透過流束は数十倍に増加した。
Membrane filtration of microbial suspension
1990
Grant type:Competitive
菌体懸濁液のクロスフロー濾過
1990
Grant type:Competitive
微生物菌体分離のためのクロスフロ-濾過法の高効率化
Grant number:02203238
1990
System name:科学研究費助成事業
Research category:重点領域研究
Awarding organization:日本学術振興会
中西 一弘, 田中 孝明, 富田 憲史
Grant amount:\3000000 ( Direct Cost: \3000000 )
本年度は以下の三点の項目に関して検討を行った。
(1)パン酵母懸濁液のクロスフロ-濾過機構の解明
薄層流路型クロスフロ-濾過装置を用いて、パン酵母懸濁液のクロスフロ-濾過を行い、その膜透過流束に及ぼす諸因子を調べた。これらの実験結果から、膜透過機構に関して検討を行ったところ以下の知見が得られた。濾過開始直後においては、きわめて短期間であるが、菌体はDeadーend型の濾過の場合と同様な充填構造を取りながらも膜面上に堆積する。その後、菌体付着層表面近傍において、内部よりも密な構造の付着層が形成されることが明らかにされた。この理由として循環中に一部の菌体が変形しやすい構造に変質するためであることが示唆された。
(2)膜透過流束を高くするための新規な操作方法の開発
高い膜透過流束を得る目的で、種々の操作方法を検討した結果、濾口を周期的に開閉し、しかも濾口を閉じた時に気泡を供給すると、膜透過流束が数倍から10倍増加することが判明した。最適な条件では、2%のパン酵母懸濁液を10%に濃縮した場合の平均膜透過流束は3501/h・m^2に達した。
(3)高粘性培養液のクロスフロ-濾過
微生物菌体の中には、多糖など高分子物質を分泌するものが少なくない。これらの高分子物質は食品添加剤や生理活性物質としての理用が注目されている。本研究では、ケ-ススタディ-として、<Aureobasidium>___ー <pullulanns>___ーによる多糖プルランの発酵生産を行い、その高粘性培養液からの菌体の回収をクロスフロ-濾過法により行った。膜透過流束は低に値であったが、濾液は完全に清澄であり、プルランの膜透過率も90%と高く、クロスフロ-濾過法の有用性が示された。
Syntheses of Umami Peptides with Immobilized Papain in Water-Immiscible Organic Solvent Systems
Grant number:01560151
1989 - 1990
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for General Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
NAKANISHI Kazuhiro, TANAKA Takaaki
Grant amount:\2200000 ( Direct Cost: \2200000 )
Dipeptides such as L-glutamic acid dimer and L-glutamic acid dimer are known as a substance posessing umami (brothy) taste and a bitter taste masking effect. In this study, we attempted to synthesize precursors of four peptides, i. e., GluGlu, GluAsp, AspGlu, and AspAsp with an immobilized papain in organic solvent systems. As an acid component of a substrate, N-(benzyloxycarbonyl)-L-glutamic acid and N-(benzyloxycarbonyl)-L-aspartic acid, and as an amine component L-glutanic acid diethyl ester and L-aspartic acid diethyl ester were used. In most cases, we focussed on the synthesis of N-(benzyloxycarbonyl)-L-glutamyl-L-glutamic acid diethyl ester (Z-GluGlu(OEt)_2) at 30 ^゚C.
The results obtained are Summarized as follows :
1) The synthetic reaction did not take place in buffer solution.
2) In the aqueous-organic biphasic reaction systems with ethyl acetate as an organic solvent, the maximum yield of Z-GluGlu (OEt) _2 reached about 70%.
3) The enzyme was immobilized onto various porous supports. The enzyme was first adsorbed onto the support and then cross-linked with glutaraldehyde. The highest activity was obtained when the enzyme was adsorbed onto porous ceramic support (SM10-C1, Nippon Gaishi K. K.).
4) The activity of immobilized enzyme depended strongly on the water content in an outer organic solvent. The highest activity was obtained at a water content of 2.5% with the enzyme immobilized onto SM10-C1.
5) L-Glutamic acid diethyl ester, an amine component of the substrate was non-enzymatically coverted to L-pyroglutamic acid diethyl ester. To reduce the effect of non-enzymatic reaction, the increase of the concentration of the immobilized enzyme was found most effective. With 100 mM Z-Glu and 200 mM Glu (OEt) _2, and immobilized enzyme concentration of 8%, the yield became higher than 90%.
6) The other three dipeptides precursors were also obtained with quite a high yield under the same reaction conditions as shown in (5).
7) The products were identified by analyzing with nuclear magnetic resonance, mass spectrum, and infrared adsorption spectrum.
生物分離工学
Grant type:Competitive
酵素利用技術
Grant type:Competitive
膜分離技術(特に精密濾過)
Grant type:Competitive
国際工学概論
統合化学入門
インターンシップ
機能材料工学実験II
リメディアル演習
生物機能材料科学
論文輪講II
技術英語I
技術英語II
論文輪講I
先端科学技術総論
材料科学実験II
総合工学概論
工学リテラシー入門(化学材料分野)
材料科学概論
基礎有機化学
生物機能材料科学
材料生産システム博士特定研究Ⅱ
中間発表
材料生産システム博士セミナーⅡ
情報機器操作入門
外国語論文解説・討論Ⅱ
機能材料化学概論
外国語論文解説・討論Ⅰ
機能材料科学コース演習
技術英語入門
技術者倫理
材料生産システム博士特定研究Ⅰ
材料生産システム博士セミナーⅠ
自然科学総論Ⅱ
機能材料科学文献詳読Ⅱ
機能材料科学セミナーⅡ
材料生産システム特定研究Ⅱ
機能材料科学演習
機能材料科学文献詳読Ⅰ
機能材料科学セミナーⅠ
材料生産システム特定研究Ⅰ
研究発表演習・発表
卒業研修
機能材料科学総論Ⅱ
工学リテラシー入門(機能材料工学科)
最先端技術を支える化学 II
機能材料工学実験IV
スタディスキルズ(機能材料工学)
卒業研究
生物材料工学
生物反応プロセス工学
論文輪講
技術英語
機能材料工学実験III
基礎物理化学
化学実験
生物素材工学特論
卒業基礎研究