Faculty Profiles - WATANABE Yuichiro

写真a

WATANABE Yuichiro

Organization

University Medical and Dental Hospital Uonuma Institute of Community Medicine Specially Appointed Professor
Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine Specially Appointed Professor

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Degree

医学博士 ( 2005.3 新潟大学 )

Research Areas

Life Science / Psychiatry

Research History (researchmap)

Niigata University Medical and Dental Hospital Uonuma Institute of Community Medicine Specially Appointed Professor

2023.4

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Niigata University Graduate School of Medical and Dental Sciences Associate Professor

2018.4 - 2023.3

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Niigata University Uonuma Institute of Community Medicine, Medical and Dental Hospital Specially Appointed Professor

2015.6 - 2018.3

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Niigata University Graduate School of Medical and Dental Sciences Associate Professor

2012.4 - 2015.5

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Niigata University Research Institute for Natural Hazards and Disaster Recovery Division of Environmental Safety Section of Disaster Medicine Associate Professor

2012.4 - 2015.3

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Niigata University Faculty of Medicine Lecturer

2011.11 - 2012.3

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Niigata University Research Institute for Natural Hazards and Disaster Recovery Lecturer

2011.4 - 2012.3

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Niigata University Headquarters for Health Administration Health Administration Center Lecturer

2009.4 - 2012.3

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Niigata University Research Center for Natural Hazards and Disaster Recovery Lecturer

2009.4 - 2011.3

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Niigata University Research Center for Natural Hazards and Disaster Recovery Assistant Professor

2008.5 - 2009.3

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Niigata University Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine Assistant Professor

2007.12 - 2009.3

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Niigata University University Medical and Dental Hospital Assistant Professor

2005.5 - 2007.11

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Niigata University Brain Research Institute

2005.4

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Research History

Niigata University Sensory and Integrative Medicine, Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences Specially Appointed Professor

2023.4
Niigata University UONUMA CHIIKI IRYO KYOIKU CENTER, University Medical and Dental Hospital Specially Appointed Professor

2023.4
Niigata University Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine Associate Professor

2018.4 - 2023.3
Niigata University University Medical and Dental Hospital UONUMA CHIIKI IRYO KYOIKU CENTER JUNBISHITU Specially Appointed Professor

2015.6 - 2018.3
Niigata University Faculty of Medicine School of Medicine Associate Professor

2012.4 - 2015.5
Niigata University Research Institute for Natural Hazards and Disaster Recovery Division of Environmental Safety Section of Disaster Medicine Associate Professor

2012.4 - 2015.5
Niigata University Graduate School of Medical and Dental Sciences Associate Professor

2012.4 - 2015.5
Niigata University Faculty of Medicine Lecturer

2011.11 - 2012.3
Niigata University Research Institute for Natural Hazards and Disaster Recovery Lecturer

2011.4 - 2012.3
Niigata University Health Administration Center Lecturer

2009.4 - 2012.3
Niigata University Research Center for Natural Hazards and Disaster Recovery Lecturer

2009.4 - 2011.3
Niigata University Research Center for Natural Hazards and Disaster Recovery Assistant Professor

2008.5 - 2009.3
Niigata University Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine Assistant Professor

2007.12 - 2009.3
Niigata University University Medical and Dental Hospital Assistant Professor

2005.5 - 2007.11
Niigata University Brain Research Institute

2005.4 - 2023.3

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Education

Niigata University Graduate School of Medical and Dental Sciences

- 2005.3

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Niigata University Faculty of Medicine

- 1998.3

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Qualification acquired

日本医師会認定産業医
日本精神神経学会指導医
日本精神神経学会専門医
精神保健指定医
Doctor

Papers

Rare nonsynonymous germline and mosaic de novo variants in Japanese patients with schizophrenia. International journal

Yuichiro Watanabe, Masaki Nishioka, Ryo Morikawa, Satoko Takano-Isozaki, Hirofumi Igeta, Kanako Mori, Tadafumi Kato, Toshiyuki Someya

Psychiatry and clinical neurosciences 2024.10

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AIM: Whole-exome sequencing (WES) studies have revealed that germline de novo variants (gDNVs) contribute to the genetic etiology of schizophrenia. However, the contribution of mosaic DNVs (mDNVs) to the risk of schizophrenia remains to be elucidated. In the present study, we systematically investigated the gDNVs and mDMVs that contribute to the genetic etiology of schizophrenia in a Japanese population. METHODS: We performed deep WES (depth: 460×) of 73 affected offspring and WES (depth: 116×) of 134 parents from 67 families with schizophrenia. Prioritized rare nonsynonymous gDNV and mDNV candidates were validated using Sanger sequencing and ultra-deep targeted amplicon sequencing (depth: 71,375×), respectively. Subsequently, we performed a Gene Ontology analysis of the gDNVs and mDNVs to obtain biological insights. Lastly, we selected DNVs in known risk genes for psychiatric and neurodevelopmental disorders. RESULTS: We identified 62 gDNVs and 98 mDNVs. The Gene Ontology analysis of mDNVs implicated actin filament and actin cytoskeleton as candidate biological pathways. There were eight DNVs in known risk genes: splice region gDNVs in AKAP11 and CUL1; a frameshift gDNV in SHANK1; a missense gDNV in SRCAP; missense mDNVs in CTNNB1, GRIN2A, and TSC2; and a nonsense mDNV in ZFHX4. CONCLUSION: Our results suggest the potential contributions of rare nonsynonymous gDNVs and mDNVs to the genetic etiology of schizophrenia. This is the first report of the mDNVs in schizophrenia trios, demonstrating their potential relevance to schizophrenia pathology.

DOI： 10.1111/pcn.13758

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Decreased oral function in Japanese inpatients with schizophrenia

Yuichiro Watanabe, Masataka Otake, Shin Ono, Masaya Ootake, Kazuhiro Murakami, Koichiro Kumagai, Koji Matsuzawa, Hiroyuki Kasahara, Kazuhiro Hori, Toshiyuki Someya

Neuropsychopharmacology Reports 2024.4

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Abstract

Aim

Oral function in patients with schizophrenia has not been well‐characterized. To address this, we performed a cross‐sectional study of oral function in Japanese inpatients with schizophrenia.

Methods

We measured oral function, including occlusal force, tongue–lip motor function, tongue pressure, and masticatory function in 130 Japanese inpatients with schizophrenia. We then compared the frequency of clinical signs of oral hypofunction among 63 non‐elderly and 67 elderly inpatients with schizophrenia, as well as data from 98 elderly control participants from a previous Japanese study.

Results

The frequency of reduced occlusal force was significantly higher in the elderly inpatients (76.2%) than in the non‐elderly inpatients (43.9%) and elderly controls (43.9%). The frequency of decreased tongue–lip motor function in non‐elderly inpatients (96.8%) and elderly inpatients (97.0%) was significantly higher than that in elderly controls (56.1%). The frequency of decreased tongue pressure in non‐elderly inpatients (66.1%) and elderly inpatients (80.7%) was significantly higher than that in elderly controls (43.9%). Finally, the frequency of decreased masticatory function was highest in elderly inpatients (76.5%), followed by non‐elderly inpatients (54.8%) and elderly controls (15.3%).

Conclusion

Oral function was decreased in both non‐elderly and elderly Japanese inpatients with schizophrenia compared with elderly controls.

DOI： 10.1002/npr2.12443

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Association between copy number variations in parkin (PRKN) and schizophrenia and autism spectrum disorder: A case-control study. International journal

Tzuyao Lo, Itaru Kushima, Hiroki Kimura, Branko Aleksic, Takashi Okada, Hidekazu Kato, Toshiya Inada, Yoshihiro Nawa, Youta Torii, Maeri Yamamoto, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Shusuke Numata, Kiyoto Kasai, Tsukasa Sasaki, Shigeru Yokoyama, Toshio Munesue, Ryota Hashimoto, Yuka Yasuda, Michiko Fujimoto, Masahide Usami, Masanari Itokawa, Makoto Arai, Kazutaka Ohi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Hidenori Yamasue, Nakao Iwata, Masashi Ikeda, Norio Ozaki

Neuropsychopharmacology reports 44 ( 1 ) 42 - 50 2024.3

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AIM: The present study aimed to examine the association between copy number variations (CNVs) in parkin (PRKN) and schizophrenia (SCZ) and autism spectrum disorder (ASD) in a large case-control sample. METHOD: Array comparative genomic hybridization was performed on 3111 cases with SCZ, 1236 cases with ASD, and 2713 controls. We systematically prioritized likely pathogenic CNVs (LP-CNVs) in PRKN and examined their association with SCZ and ASD. RESULTS: In total, 3014 SCZ cases (96.9%), 1205 ASD cases (97.5%), and 2671 controls (98.5%) passed quality control. We found that monoallelic carriers of LP-CNVs in PRKN were common (70/6890, 1.02%) and were not at higher risk of SCZ (p = 0.29) or ASD (p = 0.72). We observed that the distribution pattern of LP-CNVs in the Japanese population was consistent with those in other populations. We also identified a patient diagnosed with SCZ and early-onset Parkinson's disease carrying biallelic pathogenic CNVs in PRKN. The absence of Parkinson's symptoms in 10 other monoallelic carriers of the same pathogenic CNV further reflects the lack of effect of monoallelic pathogenic variants in PRKN in the absence of a second hit. CONCLUSION: The present findings suggest that monoallelic CNVs in PRKN do not confer a significant risk for SCZ or ASD. However, further studies to investigate the association between biallelic CNVs in PRKN and SCZ and ASD are warranted.

DOI： 10.1002/npr2.12370

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Usefulness of the autism spectrum quotient (AQ) in screening for autism spectrum disorder and social communication disorder. International journal

Kiyohiro Yoshinaga, Jun Egawa, Yuichiro Watanabe, Hiroyuki Kasahara, Atsunori Sugimoto, Toshiyuki Someya

BMC psychiatry 23 ( 1 ) 831 - 831 2023.11

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BACKGROUND: In the Diagnostic and Statistical Manual and Mental Disorders, Fifth Edition (DSM-5), autism spectrum disorder (ASD) and social (pragmatic) communication disorder (SCD) were described as a new category of psychiatry nosography. SCD involves impairments in social communication and social interaction but not restricted, repetitive patterns of behavior, interests, or activities. The autism spectrum quotient (AQ) was developed to screen for autism tendencies in adults with normal intelligence. However, AQ cutoff scores for screening ASD and SCD in the DSM-5 have not been established. This study examined whether the Japanese version of the AQ (AQ-J) total scores could discriminate between an ASD group, an SCD group, and a neurotypical (NT) group. METHODS: Participants were 127 ASD patients, 52 SCD patients, and 49 NT individuals. Receiver operating characteristic (ROC) analyses were used to examine AQ-J total score cutoff values to distinguish between ASD and NT groups, SCD and NT groups, and ASD and SCD groups. RESULTS: In the ROC analysis for the ASD and NT groups, the area under the curve (AUC) was 0.96, and the optimum cutoff value was 23 points (sensitivity 92.9%, specificity 85.7%). The AUC for the SCD and NT groups was 0.89, and the optimum cutoff value was 22 points (sensitivity 84.6%, specificity 85.7%). The AUC for the ASD and SCD groups was 0.75; the optimum cutoff value was 32 points (sensitivity 67.7%, specificity 71.2%). CONCLUSION: Our findings suggest the usefulness of the AQ-J in screening for ASD and SCD.

DOI： 10.1186/s12888-023-05362-y

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The three-factor structure of the Autism-Spectrum Quotient Japanese version in pregnant women

Ekachaeryanti Zain, Naoki Fukui, Yuichiro Watanabe, Koyo Hashijiri, Takaharu Motegi, Maki Ogawa, Jun Egawa, Koji Nishijima, Toshiyuki Someya

Frontiers in Psychiatry 14 2023.10

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Background

There is a rising interest in perinatal mental health studies, and proper psychometric tools to assess autistic traits among this population in Japan are vital.

Objective

This study aimed to clarify the optimal factor structure of the AQ as part of a perinatal mental health research project.

Methods

We used the Japanese version of the AQ (AQ-J) to measure autistic-like traits in pregnant women. Participants were 4,287 Japanese women who were pregnant or who had given birth within the last month. We performed exploratory factor analysis (EFA) using the first sample group (n = 2,154) to obtain factor structures for the final item selections. We performed confirmatory factor analysis (CFA) using the second sample group (n = 2,133) to obtain a model with good fit, then compared the model to all previously proposed models to determine the best-fitting model.

Results

The EFA analysis identified a model consisting of 25 items distributed across three factors. Cronbach’s alpha for the total 25-item AQ-J, 9-item “Social interaction” factor, 11-item “Non-verbal communication” factor, and 5-item “Restricted interest” factor was 0.829, 0.829, 0.755, and 0.576, respectively. McDonald’s omega and its 95% confidence interval were 0.826 (0.821–0.836), 0.835 (0.821–0.837), 0.755 (0.744–0.766), and 0.603 (0.556–0.596), respectively. CFA confirmed that the three-factor structure had an acceptable fit (goodness of fit index: 0.900, comparative fit index: 0.860, root mean square error of approximation: 0.066). These findings indicated that the three-factor model was better than the 13 existing models.

Conclusion

The findings are discussed in relation to the adequacy of the AQ-J for assessing autistic traits in perinatal women. We recommend the use of this 25-item, three-factor AQ-J model for this population owing to its superiority to all previous models.

DOI： 10.3389/fpsyt.2023.1275043

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Association between insulin resistance and serum insulin-like growth factor 1 levels in patients with non-remitting major depressive disorder. International journal

Hiroshi Arinami, Yutaro Suzuki, Yuichiro Watanabe, Misuzu Tajiri, Nobuto Tsuneyama, Toshiyuki Someya

Journal of affective disorders 2023.10

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BACKGROUND: Major depressive disorder (MDD) is linked to an increased risk of diabetes; however, the underlying pathomechanism remains unknown. Although insulin-like growth factor 1 (IGF-1) is involved in the pathogenesis of both insulin resistance (IR) and MDD, no studies have investigated the relationship between IGF-1 and IR in patients with MDD. METHODS: We recruited 120 patients with MDD (84 non-remitting patients and 36 remitting patients) and 99 control participants. Blood samples were collected after overnight fasting to investigate associations between serum and clinical factors, such as serum IGF-1 levels and homeostasis model assessment-insulin resistance (HOMA-IR). RESULTS: Serum IGF-1 levels were higher in patients with non-remitting MDD than in control participants and patients with remitting MDD (P = 0.001 and P = 0.007, respectively). There were no significant differences in HOMA-IR between the three groups. HOMA-IR was positively correlated with serum IGF-1 levels in patients with non-remitting MDD (R = 0.355; P= 0.001) but not in control participants or patients with remitting MDD. A stepwise multiple regression analysis with various clinical factors revealed a positive association of serum IGF-1 levels and body mass index with HOMA-IR in patients with non-remitting MDD. LIMITATIONS: This is a cross-sectional study and therefore we cannot draw firm conclusions about causal associations. CONCLUSIONS: Serum IGF-1 levels may play a role in IR in patients with MDD who fail to achieve remission. Further studies, including longitudinal studies, are needed to determine the relationship between high serum IGF-1 levels and subsequent IR and diabetes risk.

DOI： 10.1016/j.jad.2023.10.009

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High care and low overprotection from both paternal and maternal parents predict a secure attachment style with a partner among perinatal Japanese women

Ekachaeryanti Zain, Naoki Fukui, Yuichiro Watanabe, Koyo Hashijiri, Takaharu Motegi, Maki Ogawa, Jun Egawa, Toshiyuki Someya

Scientific Reports 13 ( 1 ) 2023.9

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Abstract

This study aimed to determine how paternal and maternal parenting before adolescence affects adult attachment to a partner during the perinatal period, using three different models of attachment. We used the Parental Bonding Instrument (PBI) and the Relationship Questionnaire (RQ) to examine perceived parenting practices and adult attachment styles, respectively. The participants included 4586 Japanese women who were pregnant or who had given birth, up until one month after childbirth. We performed structural equation modeling analysis between PBI and RQ scores with three different category models, including the four-category model (secure, fearful, preoccupied, and dismissive attachment) as Model 1, the two-category model (model of the self and others) as Model 2, and the single-category model (total attachment style) as Model 3. Models 1 and 2 showed a good fit. Both path models showed a significant association between adult attachment style and perceived paternal and maternal parenting before adolescence, where high care and low overprotection from both paternal and maternal parents predicted adult attachment. Our findings indicate that attachment styles are best described using the four-category and two-category models, and suggest that both paternal and maternal overprotection and care influence adult attachment with a partner during the perinatal period.

DOI： 10.1038/s41598-023-42674-1

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Other Link： https://www.nature.com/articles/s41598-023-42674-1
Relationships among autistic traits, depression, anxiety, and maternal–infant bonding in postpartum women

Naoki Fukui, Yuichiro Watanabe, Takaharu Motegi, Koyo Hashijiri, Maki Ogawa, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

BMC Psychiatry 23 ( 1 ) 2023.6

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Abstract

Background

Although several studies have found significant relationships between autistic traits and depression/anxiety, the relationships between autistic traits and postpartum depression/anxiety remain unclear. Moreover, few studies have examined the relationships between autistic traits and mother–infant bonding while considering depression or anxiety.

Methods

This study used a cross-sectional data analysis design. Participants were 2692 women who completed the Autism-Spectrum Quotient (AQ), Hospital Anxiety and Depression Scale (HADS), and Mother-to-Infant Bonding Scale (MIBS) at 1 month postpartum. We performed path analysis that included parity, the five AQ subscales (social skills, attention switching, attention to detail, communication, and imagination), both HADS subscales (anxiety and depression), and the two MIBS subscales (lack of affection and anger and rejection).

Results

Our path analysis revealed that higher scores for social skills, attention switching, communication, and imagination were associated with higher scores for depression. Higher scores for social skills, attention switching, attention to detail, and communication were associated with higher scores for anxiety. Moreover, difficulties in social skills and imagination were associated with failure of maternal–infant bonding. However, more attention to detail was associated with better maternal–infant bonding.

Conclusions

This study suggests that maternal autistic traits are related to anxiety and depression to a certain degree, but only slightly related to maternal–infant bonding at 1 month postpartum. To improve autistic women’s quality of life and that of their newborns, perinatal mental health issues such as anxiety, depression, and maternal–fetal bonding difficulties should be appropriately addressed.

DOI： 10.1186/s12888-023-04970-y

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Other Link： https://link.springer.com/article/10.1186/s12888-023-04970-y/fulltext.html
Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia. International journal

Hiroshi Arinami, Yuichiro Watanabe, Yutaro Suzuki, Misuzu Tajiri, Nobuto Tsuneyama, Toshiyuki Someya

Scientific reports 13 ( 1 ) 1148 - 1148 2023.1

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The pathophysiology underlying major depressive disorder (MDD) and schizophrenia is related to endocrine system functions and includes changes in the blood levels of cortisol and insulin-like growth factor 1 (IGF-1). However, these hormones have not been investigated simultaneously in patients with MDD and schizophrenia. We investigated the differences in serum cortisol and IGF-1 levels among patients with MDD and schizophrenia and controls. We included 129 patients with MDD, 71 patients with schizophrenia, and 71 healthy volunteers. Blood tests were performed between 6:00 am and 11:00 am after fasting. Serum cortisol levels were significantly higher in patients with schizophrenia than in patients with MDD and controls. Serum cortisol levels were significantly higher in patients with MDD than in controls. Serum IGF-1 levels were higher in both patient groups than in controls, whereas there was no significant difference between patients with MDD and schizophrenia. Both cortisol and IGF-1 levels were positively correlated with the Hamilton Rating Scale for Depression score in patients with MDD, whereas cortisol level was positively correlated and IGF-1 level was negatively correlated with the Brief Psychiatric Rating Scale score in patients with schizophrenia. The differences in the level of these hormones suggest pathophysiological differences between these disorders.

DOI： 10.1038/s41598-023-28449-8

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Factor structure of the parental bonding instrument for pregnant Japanese women. International journal

Naoki Fukui, Yuichiro Watanabe, Koyo Hashijiri, Takaharu Motegi, Maki Ogawa, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

Scientific reports 12 ( 1 ) 19071 - 19071 2022.11

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The parental bonding instrument (PBI) is often used to examine the perceptions of children and adolescents regarding parenting practices. Previous studies have investigated the factor structure of the PBI. However, although it is important to examine the relationships between the perceived parenting practices and perinatal mental health, few studies have included perinatal women. We aimed to accurately clarify which PBI factor structure was useful in assessing perinatal women (n = 4633). Furthermore, we evaluated the measurement invariance between primipara and multipara groups, and between the paternal and maternal PBI forms. Our exploratory and confirmatory factor analyses revealed that a three-factor PBI structure was most plausible for perinatal women. Moreover, we found complete invariance (residual invariance) of the PBI ratings across primipara and multipara women for the paternal and maternal forms. In contrast, we found weak invariance (metric invariance) of the PBI ratings across the paternal and maternal forms. Our participants tended to rate fathers as less caring and less overprotective than mothers. This three-factor structure shows measurement invariance in perinatal women and can be used to accurately determine how the perceived parenting style before adolescence influences women's mental health in the perinatal period.

DOI： 10.1038/s41598-022-22017-2

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Clinical manifestations of schizophrenia in four patients with variants in voltage-gated calcium channel-encoding genes: a case series. International journal

Tzuyao Lo, Itaru Kushima, Branko Aleksic, Akira Yoshimi, Toshiyuki Someya, Yuichiro Watanabe, Norio Ozaki

Psychiatry and clinical neurosciences 77 ( 1 ) 57 - 59 2022.10

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DOI： 10.1111/pcn.13494

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Associations between the number of antipsychotics prescribed and metabolic parameters in Japanese patients with schizophrenia

Yuichiro Watanabe, Shin Ono, Takuro Sugai, Yutaro Suzuki, Manabu Yamazaki, Norio Sugawara, Norio Yasui‐Furukori, Kazutaka Shimoda, Takao Mori, Yuji Ozeki, Hiroshi Matsuda, Kurefu Okamoto, Toyoaki Sagae, Toshiyuki Someya

Psychiatry and Clinical Neurosciences Reports 1 ( 3 ) 2022.7

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DOI： 10.1002/pcn5.28

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/pcn5.28
A case presenting with a major depressive episode with palilalia and difficulty opening eyes as prodromal symptoms of progressive supranuclear palsy

Koji Matsuzawa, Yuichi Yokoyama, Yuichiro Watanabe, Takahiro Wakasugi, Toshiyuki Someya

Psychiatry and Clinical Neurosciences Reports 1 ( 2 ) 2022.6

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DOI： 10.1002/pcn5.24

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Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder. International journal

Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-Ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki

Biological psychiatry 92 ( 5 ) 362 - 374 2022.4

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BACKGROUND: We aimed to determine the similarities and differences in the roles of genic and regulatory copy number variations (CNVs) in bipolar disorder (BD), schizophrenia (SCZ), and autism spectrum disorder (ASD). METHODS: Based on high-resolution CNV data from 8708 Japanese samples, we performed to our knowledge the largest cross-disorder analysis of genic and regulatory CNVs in BD, SCZ, and ASD. RESULTS: In genic CNVs, we found an increased burden of smaller (<100 kb) exonic deletions in BD, which contrasted with the highest burden of larger (>500 kb) exonic CNVs in SCZ/ASD. Pathogenic CNVs linked to neurodevelopmental disorders were significantly associated with the risk for each disorder, but BD and SCZ/ASD differed in terms of the effect size (smaller in BD) and subtype distribution of CNVs linked to neurodevelopmental disorders. We identified 3 synaptic genes (DLG2, PCDH15, and ASTN2) as risk factors for BD. Whereas gene set analysis showed that BD-associated pathways were restricted to chromatin biology, SCZ and ASD involved more extensive and similar pathways. Nevertheless, a correlation analysis of gene set results indicated weak but significant pathway similarities between BD and SCZ or ASD (r = 0.25-0.31). In SCZ and ASD, but not BD, CNVs were significantly enriched in enhancers and promoters in brain tissue. CONCLUSIONS: BD and SCZ/ASD differ in terms of CNV burden, characteristics of CNVs linked to neurodevelopmental disorders, and regulatory CNVs. On the other hand, they have shared molecular mechanisms, including chromatin biology. The BD risk genes identified here could provide insight into the pathogenesis of BD.

DOI： 10.1016/j.biopsych.2022.04.003

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Novel missense SETD1A variants in Japanese patients with schizophrenia: Resequencing and association analysis. International journal

Ryo Morikawa, Yuichiro Watanabe, Hirofumi Igeta, Reza K Arta, Masashi Ikeda, Satoshi Okazaki, Satoshi Hoya, Takeo Saito, Ikuo Otsuka, Jun Egawa, Takaki Tanifuji, Nakao Iwata, Toshiyuki Someya

Psychiatry research 310 114481 - 114481 2022.4

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SETD1A has been identified as a substantial risk gene for schizophrenia. To further investigate the role of SETD1A in the genetic etiology of schizophrenia in the Japanese population, we performed resequencing and association analyses. First, we resequenced the SETD1A coding regions of 974 patients with schizophrenia. Then, we genotyped variants, prioritized via resequencing, in 2,027 patients with schizophrenia and 2,664 controls. Next, we examined the association between SETD1A and schizophrenia in 3,001 patients with schizophrenia and 2,664 controls. Finally, we performed a retrospective chart review of patients with prioritized SETD1A variants. We identified two novel missense variants (p.Ser575Pro and p.Glu857Gln) via resequencing. We did not detect these variants in 4,691 individuals via genotyping. These variants were not significantly associated with schizophrenia in the association analysis. Additionally, we found that a schizophrenia patient with the p.Glu857Gln variant had developmental delays. In conclusion, novel SETD1A missense variants were exclusively identified in Japanese patients with schizophrenia. However, our study does not provide evidence for the contribution of these variants to the genetic etiology of schizophrenia in the Japanese population.

DOI： 10.1016/j.psychres.2022.114481

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Polymorphisms in the hypoxia inducible factor binding site of the macrophage migration inhibitory factor gene promoter in schizophrenia. International journal

Satoshi Okazaki, Shuken Boku, Yuichiro Watanabe, Ikuo Otsuka, Tadasu Horai, Ryo Morikawa, Atsushi Kimura, Naofumi Shimmyo, Takaki Tanifuji, Toshiyuki Someya, Akitoyo Hishimoto

PloS one 17 ( 3 ) e0265738 2022

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BACKGROUND: Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine that promotes neurogenesis and neuroprotection. MIF is predominantly expressed in astrocytes in the brain. The serum MIF level and microsatellites/single nucleotide polymorphisms (SNPs) in the MIF gene promoter region are known to be associated with schizophrenia (SCZ). Interestingly, previous studies reported that hypoxia, an environmental risk factor for SCZ, induced MIF expression through binding of the hypoxia inducible factor (HIF)-1 to the hypoxia response element (HRE) in the MIF promoter. METHODS: We investigated the involvement of MIF in SCZ while focusing on the HIF pathway. First, we conducted an association study of the SNP rs17004038 (C>A) in the HRE of the MIF promoter between 1758 patients with SCZ and 1507 controls. Next, we investigated the effect of hypoxia on MIF expression in primary cultured astrocytes derived from neonatal mice forebrain. RESULTS: SNP rs17004038 was significantly associated with SCZ (p = 0.0424, odds ratio = 1.445), indicating that this SNP in the HRE of the MIF promoter was a genetic risk factor for SCZ. Hypoxia induced MIF mRNA expression and MIF protein production and increased HIF-1 binding to the MIF promoter, while the activity of the MIF promoter was suppressed by mutations in the HRE and by deletion of the HRE in astrocytes. CONCLUSION: These results suggest that SNP rs17004038 in the HRE of the MIF promoter was significantly associated with SCZ and may be involved in the pathophysiology of SCZ via suppression of hypoxia and HIF pathway-induced MIF expression.

DOI： 10.1371/journal.pone.0265738

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Association Between the Number of Remaining Teeth and Body Mass Index in Japanese Inpatients with Schizophrenia. International journal

Masataka Otake, Shin Ono, Yuichiro Watanabe, Koichiro Kumagai, Koji Matsuzawa, Hiroyuki Kasahara, Masaya Ootake, Takuro Sugai, Toshiyuki Someya

Neuropsychiatric disease and treatment 18 2591 - 2597 2022

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PURPOSE: There is little evidence regarding the effects of dental status on body mass index (BMI) in inpatients with schizophrenia. Thus, we performed a cross-sectional study to explore the associations between the number of remaining teeth and BMI in Japanese inpatients with schizophrenia. PATIENTS AND METHODS: We performed multiple regression analysis to assess the effects of potential predictors (age, sex, number of remaining teeth, number of antipsychotics prescribed, chlorpromazine equivalent dose, and antipsychotic type) on BMI in 212 inpatients with schizophrenia. We then compared the number of remaining teeth between inpatients with schizophrenia and the Japanese general population (3283 individuals) from the Japan Dental Diseases Survey 2016, using an analysis of covariance with age and sex as covariates. RESULTS: Multiple regression analysis showed that the number of remaining teeth and the number of antipsychotics prescribed were significantly correlated with BMI (standardized regression coefficient = 0.201 and 0.235, respectively). In the analysis of covariance, inpatients with schizophrenia had significantly fewer remaining teeth compared with the Japanese general population (mean 14.8 [standard deviation: 10.9] vs mean 23.0 [standard deviation: 8.1]). CONCLUSION: These results suggested that tooth loss and antipsychotic polypharmacy affect BMI in inpatients with schizophrenia, and that inpatients with schizophrenia lose more teeth compared with the general population.

DOI： 10.2147/NDT.S387724

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Perceived parenting before adolescence and parity have direct and indirect effects via depression and anxiety on maternal-infant bonding in the perinatal period. International journal

Naoki Fukui, Takaharu Motegi, Yuichiro Watanabe, Koyo Hashijiri, Ryusuke Tsuboya, Maki Ogawa, Takuro Sugai, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

Psychiatry and clinical neurosciences 75 ( 10 ) 312 - 317 2021.10

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AIM: This study was aimed towards detecting how perceived parenting practices before adolescence affect maternal-infant bonding in the perinatal period, considering factors such as depression, anxiety, and parity. METHODS: We used the Parental Bonding Instrument (PBI) to examine perceived parenting practices. Participants included 1301 pregnant women who completed the Hospital Anxiety and Depression Scale (HADS) and Mother-to-Infant Bonding Scale (MIBS) at three time points: early pregnancy (approximately 12-15 weeks), late pregnancy (approximately 30-34 weeks) and postpartum (4 weeks after childbirth). We performed a path analysis with factors including parity, PBI subscales (paternal care, paternal overprotection, maternal care and maternal overprotection), HADS and MIBS. RESULTS: Perceived paternal or maternal low care parenting predicted higher HADS and MIBS scores in early pregnancy. Moreover, perceived maternal low care parenting predicted higher HADS scores at postpartum and higher MIBS scores in late pregnancy. Perceived paternal or maternal overprotective parenting predicted higher HADS scores in the pregnancy period. Furthermore, perceived maternal overprotective parenting predicted higher MIBS scores in late pregnancy. Being primipara predicted higher HADS scores at postpartum and higher MIBS scores in early pregnancy and at postpartum. Being multipara predicted higher MIBS scores in late pregnancy. CONCLUSION: This study suggests that perceived negative parenting before adolescence has indirect effects (via anxiety and depression) and direct effects on maternal-infant bonding in the perinatal period.

DOI： 10.1111/pcn.13289

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Exclusive Breastfeeding Is Not Associated with Maternal-Infant Bonding in Early Postpartum, Considering Depression, Anxiety, and Parity. International journal

Naoki Fukui, Takaharu Motegi, Yuichiro Watanabe, Koyo Hashijiri, Ryusuke Tsuboya, Maki Ogawa, Takuro Sugai, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

Nutrients 13 ( 4 ) 2021.4

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It is important to clarify how the breastfeeding method affects women's mental health, and how women's mental health affects the breastfeeding method in the early postpartum period when major depression and other psychiatric problems are most likely to occur. This study aimed to examine this bidirectional relationship in the early postpartum period. Participants were 2020 postpartum women who completed the Hospital Anxiety and Depression Scale (HADS) and Mother-to-Infant Bonding Scale (MIBS). We obtained data for participants' breastfeeding method for four weeks after childbirth. We performed a path analysis with factors including breastfeeding method (exclusive breastfeeding or non-exclusive breastfeeding), parity (primipara or multipara), the two HADS subscales (anxiety and depression), and the two MIBS subscales (lack of affection and anger and rejection). The path analysis showed that breastfeeding method did not significantly affect depression, anxiety, and maternal-infant bonding in the early postpartum period. Women with higher anxiety tended to use both formula-feeding and breastfeeding. Our study suggests that exclusive breastfeeding is not associated with maternal-fetal bonding in early postpartum, considering depression, anxiety, and parity.

DOI： 10.3390/nu13041184

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Resequencing and association analysis of GAP43 with autism spectrum disorder and schizophrenia in a Japanese population

Reza K. Arta, Yuichiro Watanabe, Emiko Inoue, Yoshihiro Nawa, Ryo Morikawa, Jun Egawa, Itaru Kushima, Hirofumi Igeta, Satoshi Hoya, Atsunori Sugimoto, Andi J. Tanra, Norio Ozaki, Toshiyuki Someya

RESEARCH IN AUTISM SPECTRUM DISORDERS 82 2021.4

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DOI： 10.1016/j.rasd.2021.101729

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【コロナ時代の自殺対策】COVID-19パンデミックと医療従事者のメンタルヘルス

渡部雄一郎, 染矢俊幸

公衆衛生 85 ( 3 ) 156 - 159 2021.3

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Factor Structure and Measurement Invariance of the Hospital Anxiety and Depression Scale Across the Peripartum Period Among Pregnant Japanese Women. International journal

Maki Ogawa, Yuichiro Watanabe, Takaharu Motegi, Naoki Fukui, Koyo Hashijiri, Ryusuke Tsuboya, Takuro Sugai, Jun Egawa, Rie Araki, Kazufumi Haino, Masayuki Yamaguchi, Koji Nishijima, Takayuki Enomoto, Toshiyuki Someya

Neuropsychiatric disease and treatment 17 221 - 227 2021

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Purpose: The Hospital Anxiety and Depression Scale (HADS) is a self-report questionnaire widely used to assess anxiety and depression. To the best of our knowledge, only four studies have examined the factor structure of the HADS for assessing pregnant women, with conflicting results. This study aimed to assess the factor structure and measurement invariance of the HADS for use with pregnant Japanese women. Participants and Methods: A total of 936 pregnant Japanese women completed the HADS questionnaire at three time points: the first and third trimester of pregnancy, and postpartum. We examined the factor structure of the HADS in Group 1 (n = 466) using exploratory factor analysis (EFA). We then compared the models identified in Group 1 with those from previous studies using confirmatory factor analysis (CFA) in Group 2 (n = 470). We performed multiple-group CFA for Group 2 to test the measurement invariance of the best-fit model across the three time points. Results: The EFA for the Group 1 data at the three time points revealed a two-factor model. In the CFA, the two-factor model from Group 1 showed the best fit with the data at the three time points. In the multiple-group CFA for Group 2, we confirmed the configural and metric invariance of the two-factor model across the three time points. Conclusion: Our findings provide evidence for a two-factor structure and weak measurement invariance of the HADS in pregnant Japanese women during the peripartum period.

DOI： 10.2147/NDT.S294918

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Identification of Bonding Difficulties in the Peripartum Period Using the Mother-to-Infant Bonding Scale-Japanese Version and Its Tentative Cutoff Points. International journal

Koyo Hashijiri, Yuichiro Watanabe, Naoki Fukui, Takaharu Motegi, Maki Ogawa, Jun Egawa, Takayuki Enomoto, Toshiyuki Someya

Neuropsychiatric disease and treatment 17 3407 - 3413 2021

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Purpose: Identification of pregnant women with bonding difficulties is important to provide early intervention. However, few studies have examined the utility of self-report questionnaires that assess mother-infant bonding as screening tools for bonding difficulties. This longitudinal study aimed to identify pregnant women with bonding difficulties using the Japanese version of the Mother-to-Infant Bonding Scale (MIBS-J) and to estimate its optimal cutoff points in the peripartum period. Patients and Methods: A total of 1301 pregnant women completed the MIBS-J and Hospital Anxiety and Depression Scale (HADS) at three time points: first trimester (T1; approximately 12-15 weeks gestation), third trimester (T2; approximately 30-34 weeks gestation), and postpartum (T3; approximately 4 weeks postpartum). A two-step cluster analysis was conducted to classify pregnant women based on their MIBS-J subscale scores at the three time points. Based on the cluster analysis results, receiver operating characteristic curve analysis was performed to estimate the optimal cutoff scores for the MIBS-J total score at each time point. Results: The two-step cluster analysis produced two clusters: Cluster 1 (n = 824) and Cluster 2 (n = 477). Both the MIBS-J and HADS scores were significantly higher in Cluster 2 than in Cluster 1 at all time points. The MIBS-J tentative cutoff points were 3/4, 3/4, and 2/3 at T1, T2, and T3, respectively. Conclusion: We identified two distinct groups across the perinatal period: pregnant women with bonding difficulties and pregnant women with normal bonding. Our findings suggest the usefulness of the MIBS-J as a screening tool to identify bonding difficulties during pregnancy.

DOI： 10.2147/NDT.S336819

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The relationship between schizophrenia patients' attitudes towards physical health and the prevalence of metabolic syndrome

Takuro Sugai, Yutaro Suzuki, Manabu Yamazaki, Norio Sugawara, Norio Yasui-Furukori, Kazutaka Shimoda, Takao Mori, Yuji Ozeki, Yuichiro Watanabe, Hiroshi Matsuda, Kurefu Okamoto, Toyoaki Sagae, Toshiyuki Someya

Clinical Neuropsychopharmacology and Therapeutics 11 ( 0 ) 23 - 34 2020.5

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Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Clinical Neuropsychopharmacology

DOI： 10.5234/cnpt.11.23

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Whole-exome sequencing in a family with a monozygotic twin pair concordant for schizophrenia and a follow-up case-control study of identified de-novo variants. Reviewed International journal

Satoshi Hoya, Yuichiro Watanabe, Ayako Nunokawa, Ikuo Otsuka, Masako Shibuya, Hirofumi Igeta, Akitoyo Hishimoto, Toshiyuki Someya

Psychiatric genetics 30 ( 2 ) 60 - 63 2020.4

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Whole-exome sequencing (WES) studies have shown that de-novo variants contribute to the genetic etiology of schizophrenia. WES studies of families with a monozygotic twin pair concordant or discordant for a disease may be fruitful for identifying de-novo pathogenic variants. Here, we performed WES in six individuals from one family (affected monozygotic twins, their unaffected parents, and two siblings) and identified three de-novo missense variants (CPT2 Ala283Thr, CPSF3 Val584Ile, and RNF148 Val210Ile) in the monozygotic twin pair concordant for schizophrenia. These three missense variants were not found in 1760 patients with schizophrenia or schizoaffective disorder or 1508 healthy controls. Our data do not support the role of the three missense variants in conferring risk for schizophrenia.

DOI： 10.1097/YPG.0000000000000250

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Depression, Anxiety and Primiparity are Negatively Associated with Mother-Infant Bonding in Japanese Mothers. International journal

Takaharu Motegi, Yuichiro Watanabe, Naoki Fukui, Maki Ogawa, Koyo Hashijiri, Ryusuke Tsuboya, Takuro Sugai, Jun Egawa, Rie Araki, Kazufumi Haino, Masayuki Yamaguchi, Koji Nishijima, Takayuki Enomoto, Toshiyuki Someya

Neuropsychiatric disease and treatment 16 3117 - 3122 2020

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Purpose: Postpartum depression is a well-known risk factor, and postpartum anxiety and parity are potential risk factors, for mother-infant bonding disorder. However, few studies have focused on the relationships among these factors and mother-infant bonding. This cross-sectional study explored the associations between depression, anxiety and parity, and mother-infant bonding. Materials and Methods: Japanese mothers, both primiparas and multiparas, completed the Mother-to-Infant Bonding Scale (MIBS) and the Hospital Anxiety and Depression Scale (HADS) one month after childbirth. We performed a stepwise multiple regression analysis with the forward selection method to assess the effects of HADS anxiety and depression scores and parity as independent variables on mother-infant bonding as the dependent variable. Results: A total of 2379 Japanese mothers (1116 primiparas and 1263 multiparas) took part in the study. MIBS score (2.89 ± 2.68 vs 1.60 ± 2.11; p < 0.0001) was significantly higher in primiparas than in multiparas. HADS anxiety (6.55 ± 4.06 vs 4.63 ± 3.41; p < 0.0001) and depression (6.56 ± 3.43 vs 5.98 ± 3.20; p < 0.0001) scores were also significantly higher in primiparas than in multiparas. A stepwise multiple regression analysis with the forward selection method revealed that HADS depression and anxiety scores and parity were significantly associated with MIBS score (p = 0.003, 0.015 and 0.023). Conclusion: Depression, anxiety and primiparity were negatively associated with mother-infant bonding one month after childbirth.

DOI： 10.2147/NDT.S287036

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Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect. Reviewed International journal

Masashi Ikeda, Atsushi Takahashi, Yoichiro Kamatani, Yukihide Momozawa, Takeo Saito, Kenji Kondo, Ayu Shimasaki, Kohei Kawase, Takaya Sakusabe, Yoshimi Iwayama, Tomoko Toyota, Tomoyasu Wakuda, Mitsuru Kikuchi, Nobuhisa Kanahara, Hidenaga Yamamori, Yuka Yasuda, Yuichiro Watanabe, Satoshi Hoya, Branko Aleksic, Itaru Kushima, Heii Arai, Manabu Takaki, Kotaro Hattori, Hiroshi Kunugi, Yuko Okahisa, Tohru Ohnuma, Norio Ozaki, Toshiyuki Someya, Ryota Hashimoto, Takeo Yoshikawa, Michiaki Kubo, Nakao Iwata

Schizophrenia bulletin 45 ( 4 ) 824 - 834 2019.6

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Genome-wide association studies (GWASs) have identified >100 susceptibility loci for schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by numerous genetic variants but with small effect size. We conducted a GWAS in the Japanese (JPN) population (a) to detect novel SCZ-susceptibility genes and (b) to examine the shared genetic risk of SCZ across (East Asian [EAS] and European [EUR]) populations and/or that of trans-diseases (SCZ, bipolar disorder [BD], and major depressive disorder [MDD]) within EAS and between EAS and EUR (trans-diseases/populations). Among the discovery GWAS subjects (JPN-SCZ GWAS: 1940 SCZ cases and 7408 controls) and replication dataset (4071 SCZ cases and 54479 controls), both comprising JPN populations, 3 novel susceptibility loci for SCZ were identified: SPHKAP (Pbest = 4.1 × 10-10), SLC38A3 (Pbest = 5.7 × 10-10), and CABP1-ACADS (Pbest = 9.8 × 10-9). Subsequent meta-analysis between our samples and those of the Psychiatric GWAS Consortium (PGC; EUR samples) and another study detected 12 additional susceptibility loci. Polygenic risk score (PRS) prediction revealed a shared genetic risk of SCZ across populations (Pbest = 4.0 × 10-11) and between SCZ and BD in the JPN population (P ~ 10-40); however, a lower variance-explained was noted between JPN-SCZ GWAS and PGC-BD or MDD within/across populations. Genetic correlation analysis supported the PRS results; the genetic correlation between JPN-SCZ and PGC-SCZ was ρ = 0.58, whereas a similar/lower correlation was observed between the trans-diseases (JPN-SCZ vs JPN-BD/EAS-MDD, rg = 0.56/0.29) or trans-diseases/populations (JPN-SCZ vs PGC-BD/MDD, ρ = 0.38/0.12). In conclusion, (a) Fifteen novel loci are possible susceptibility genes for SCZ and (b) SCZ "risk" effect is shared with other psychiatric disorders even across populations.

DOI： 10.1093/schbul/sby140

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Rare compound heterozygous missense <i>SPATA7</i> variations and risk of schizophrenia; whole-exome sequencing in a consanguineous family with affected siblings, follow-up sequencing and a case-control study. Reviewed International journal

Igeta H, Watanabe Y, Morikawa R, Ikeda M, Otsuka I, Hoya S, Koizumi M, Egawa J, Hishimoto A, Iwata N, Someya T

Neuropsychiatric disease and treatment 15 2353 - 2363 2019

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Purpose: Whole-exome sequencing (WES) of multiplex families is a promising strategy for identifying causative variations for common diseases. To identify rare recessive risk variations for schizophrenia, we performed a WES study in a consanguineous family with affected siblings. We then performed follow-up sequencing of SPATA7 in schizophrenia-affected families. In addition, we performed a case-control study to investigate association between SPATA7 variations and schizophrenia. Patients and methods: WES was performed on two affected siblings and their unaffected parents, who were second cousins, of a multiplex schizophrenia family. Subsequently, we sequenced the coding region of SPATA7, a potential risk gene identified by the WES analysis, in 142 affected offspring from 137 families for whom parental DNA samples were available. We further tested rare recessive SPATA7 variations, identified by WES and sequencing, for associations with schizophrenia in 2,756 patients and 2,646 controls. Results: Our WES analysis identified rare compound heterozygous missense SPATA7 variations, p.Asp134Gly and p.Ile332Thr, in both affected siblings. Sequencing SPATA7 coding regions from 137 families identified no rare recessive variations in affected offspring. In the case-control study, we did not detect the rare compound heterozygous SPATA7 missense variations in patients or controls. Conclusion: Our data does not support the role of the rare compound heterozygous SPATA7 missense variations p.Asp134Gly and p.Ile332Thr in conferring a substantial risk of schizophrenia.

DOI： 10.2147/NDT.S218773

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Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia. Reviewed International journal

Yukawa T, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa SI, Takeuchi R, Takahashi H, Kakita A, Someya T, Nawa H

Psychiatry research 270 940 - 946 2018.12

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Perineuronal nets comprise chondroitin sulfate moieties and their core proteins, and their neuropathological alterations have been implicated in schizophrenia. To explore the molecular mechanism of the perineuronal net impairments in schizophrenia, we measured the immunoreactivity of chondroitin sulfate moieties, major components of perineuronal nets, in three brain regions (postmortem dorsolateral prefrontal cortex, caudate nucleus, and hippocampus) of schizophrenia patients and control subjects. Immunoblotting for chondroitin 4-sulfate and chondroitin 6-sulfate moieties revealed a significant increase in intensity of a 180 kD band of chondroitin 4-sulfate immunoreactivity in the hippocampus of patients, although we detected no significant alteration in their immunoreactivities with any other molecular sizes or in other brain regions. The levels of immunoreactivity were not correlated with postmortem interval, age, or storage time. We failed to find such an increase in a similar molecular range of the chondroitin 4-sulfate immunoreactivity in the hippocampus of the rats chronically treated with haloperidol. These results suggest that the level alteration of the chondroitin 4-sulfate moiety might contribute to the perineuronal net abnormality found in patients with schizophrenia.

DOI： 10.1016/j.psychres.2018.10.062

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Updated meta-analysis of CMYA5 rs3828611 and rs4704591 with schizophrenia in Asian populations. Reviewed

Hoya S, Watanabe Y, Shibuya M, Someya T

Early intervention in psychiatry 12 ( 5 ) 938 - 941 2018.10

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DOI： 10.1111/eip.12472

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Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights. Reviewed International journal

Itaru Kushima, Branko Aleksic, Masahiro Nakatochi, Teppei Shimamura, Takashi Okada, Yota Uno, Mako Morikawa, Kanako Ishizuka, Tomoko Shiino, Hiroki Kimura, Yuko Arioka, Akira Yoshimi, Yuto Takasaki, Yanjie Yu, Yukako Nakamura, Maeri Yamamoto, Tetsuya Iidaka, Shuji Iritani, Toshiya Inada, Nanayo Ogawa, Emiko Shishido, Youta Torii, Naoko Kawano, Yutaka Omura, Toru Yoshikawa, Tokio Uchiyama, Toshimichi Yamamoto, Masashi Ikeda, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Ayako Nunokawa, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Akiko Kobori, Michio Suzuki, Tsutomu Takahashi, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Tsukasa Sasaki, Hitoshi Kuwabara, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Yosuke Eriguchi, Seico Benner, Masaki Kojima, Walid Yassin, Toshio Munesue, Shigeru Yokoyama, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Makoto Ishitobi, Tetsuro Ohmori, Shusuke Numata, Takeo Yoshikawa, Tomoko Toyota, Kazuhiro Yamakawa, Toshimitsu Suzuki, Yushi Inoue, Kentaro Nakaoka, Yu-Ichi Goto, Masumi Inagaki, Naoki Hashimoto, Ichiro Kusumi, Shuraku Son, Toshiya Murai, Tempei Ikegame, Naohiro Okada, Kiyoto Kasai, Shohko Kunimoto, Daisuke Mori, Nakao Iwata, Norio Ozaki

Cell reports 24 ( 11 ) 2838 - 2856 2018.9

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Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs) in autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 ASD cases, 2,458 SCZ cases, and 2,095 controls in a Japanese population and confirmed an increased burden of rare exonic CNVs in both disorders. Clinically significant (or pathogenic) CNVs, including those at 29 loci common to both disorders, were found in about 8% of ASD and SCZ cases, which was significantly higher than in controls. Phenotypic analysis revealed an association between clinically significant CNVs and intellectual disability. Gene set analysis showed significant overlap of biological pathways in both disorders including oxidative stress response, lipid metabolism/modification, and genomic integrity. Finally, based on bioinformatics analysis, we identified multiple disease-relevant genes in eight well-known ASD/SCZ-associated CNV loci (e.g., 22q11.2, 3q29). Our findings suggest an etiological overlap of ASD and SCZ and provide biological insights into these disorders.

DOI： 10.1016/j.celrep.2018.08.022

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Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population. Reviewed International journal

Yuan Zhang, Akitoyo Hishimoto, Ikuo Otsuka, Yuichiro Watanabe, Shusuke Numata, Hidenaga Yamamori, Shuken Boku, Tadasu Horai, Toshiyuki Someya, Tetsuro Ohmori, Ryota Hashimoto, Ichiro Sora

Journal of psychiatric research 103 161 - 166 2018.8

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Several previous studies have investigated an association between leukocyte telomere length (LTL) and schizophrenia (SCZ). However, results have been largely inconsistent, partially due to the relatively small sample sizes in each study and heterogeneity caused by various uncontrolled confounders (e.g., duration of illness or hospitalization, lifetime antipsychotic dose, and LTL assay methods). Here, we investigate the association of LTL with SCZ with the quantitative polymerase chain reaction method in independent cohorts consisting of 1241 patients with SCZ and 1042 controls (the largest independent sample in this field). Furthermore, we examined whether duration of hospitalization and lifetime antipsychotic dose had an effect on LTL in SCZ. In all samples, we observed significantly longer LTL in patients with SCZ relative to controls. In subgroup analyses, we observed that longer telomeres in SCZ were only visible in elderly patients and not in patients under 50 years old. Moreover, significantly longer LTL in elderly patients with SCZ was only specific to those with long-term hospitalization, but not outpatients or those with short-term hospitalization. This may be because the former received more appropriate lifestyle management. Meanwhile, lifetime antipsychotic dose had no effect on LTL. Our findings suggest that consideration of the effect of age and duration of hospitalization on LTL may improve our understanding of controversial results obtained in previous studies of telomeres in SCZ.

DOI： 10.1016/j.jpsychires.2018.05.014

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Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia. Reviewed International journal

Satoshi Okazaki, Akitoyo Hishimoto, Ikuo Otsuka, Yuichiro Watanabe, Shusuke Numata, Shuken Boku, Naofumi Shimmyo, Makoto Kinoshita, Emiko Inoue, Tetsuro Ohmori, Toshiyuki Someya, Ichiro Sora

Progress in neuro-psychopharmacology & biological psychiatry 83 33 - 41 2018.4

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BACKGROUND: Numerous studies have suggested that an immune system imbalance plays an important role in schizophrenia. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine. It plays multiple roles in various biological processes, including inflammation and neurogenesis. Furthermore, several exhaustive serum proteomic profiling studies have identified MIF as a potential biomarker of schizophrenia. Here, we investigate MIF protein levels in serum and postmortem prefrontal cortex in patients with schizophrenia and controls. Moreover, we investigate the association of two functional polymorphisms in the MIF gene promoter region (MIF-794CATT5-8 microsatellite and MIF-173G/C single-nucleotide polymorphism [SNP]) with schizophrenia. METHODS: We measured serum MIF levels with an enzyme-linked immunosorbent assay (ELISA) (51 patients vs. 86 controls) and postmortem brain MIF levels with a western blotting assay (18 patients vs. 22 controls). Subsequently, we genotyped the MIF-794CATT5-8 microsatellite with a fluorescence-based fragment assay and the MIF-173G/C SNP with a TaqMan SNP genotyping assay (1483 patients vs. 1454 controls). RESULTS: Serum MIF levels were significantly higher in patients with schizophrenia than in controls (p=0.00118), and were positively correlated with antipsychotic dose (Spearman's r=0.222, p=0.0402). In addition, an earlier age of onset was observed in patients with a high serum MIF level (≥40ng/mL) than those with a low serum MIF level (<40ng/mL) (p=0.0392). However, postmortem brain MIF levels did not differ between patients with schizophrenia and controls. The association study revealed that the CATT6-G haplotype was nominally significantly associated with schizophrenia (p=0.0338), and that the CATT6 allele and CATT6-G haplotype were significantly associated with female adolescent-onset schizophrenia (AsOS) (corrected p=0.0222 and p=0.0147, respectively). CONCLUSIONS: These results suggest that serum MIF level is a potential pharmacodynamic and/or monitoring marker of schizophrenia, and is related to a novel antipsychotic effect beyond dopamine antagonism. Furthermore, the MIF gene polymorphisms are associated with the risk for schizophrenia especially in adolescent females, and are potential stratification markers of schizophrenia. Further studies of MIF are warranted to elucidate the pathophysiology of schizophrenia and the effects of antipsychotics.

DOI： 10.1016/j.pnpbp.2018.01.001

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Rare PDCD11 variations are not associated with risk of schizophrenia in Japan Reviewed

Satoshi Hoya, Yuichiro Watanabe, Akitoyo Hishimoto, Ayako Nunokawa, Naoshi Kaneko, Tatsuyuki Muratake, Naofumi Shinmyo, Ikuo Otsuka, Shujiro Okuda, Emiko Inoue, Hirofumi Igeta, Masako Shibuya, Jun Egawa, Naoki Orime, Ichiro Sora, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 71 ( 11 ) 780 - 788 2017.11

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DOI： 10.1111/pcn.12564

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Rare FBXO18 variations and risk of schizophrenia: Whole-exome sequencing in two parent-affected offspring trios followed by resequencing and case-control studies Reviewed

Satoshi Hoya, Yuichiro Watanabe, Akitoyo Hishimoto, Ayako Nunokawa, Emiko Inoue, Hirofumi Igeta, Ikuo Otsuka, Masako Shibuya, Jun Egawa, Ichiro Sora, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 71 ( 8 ) 562 - 568 2017.8

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DOI： 10.1111/pcn.12526

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High-resolution copy number variation analysis of schizophrenia in Japan Reviewed

I. Kushima, B. Aleksic, M. Nakatochi, T. Shimamura, T. Shiino, A. Yoshimi, H. Kimura, Y. Takasaki, C. Wang, J. Xing, K. Ishizuka, T. Oya-Ito, Y. Nakamura, Y. Arioka, T. Maeda, M. Yamamoto, M. Yoshida, H. Noma, S. Hamada, M. Morikawa, Y. Uno, T. Okada, T. Iidaka, S. Iritani, T. Yamamoto, M. Miyashita, A. Kobori, M. Arai, M. Itokawa, M-C Cheng, Y-A Chuang, C-H Chen, M. Suzuki, T. Takahashi, R. Hashimoto, H. Yamamori, Y. Yasuda, Y. Watanabe, A. Nunokawa, T. Someya, M. Ikeda, T. Toyota, T. Yoshikawa, S. Numata, T. Ohmori, S. Kunimoto, D. Mori, N. Iwata, N. Ozaki

MOLECULAR PSYCHIATRY 22 ( 3 ) 430 - 440 2017.3

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自閉スペクトラム症多発罹患家系の全エクソームシークエンスおよびフォローアップ研究

井上絵美子, 渡部雄一郎, 江川純, 杉本篤言, 布川綾子, 澁谷雅子, 井桁裕文, 染矢俊幸

精神神経学雑誌 119 ( 1 ) 3 - 8 2017.1

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Rare UNC13B variations and risk of schizophrenia: Whole-exome sequencing in a multiplex family and follow-up resequencing and a case-control study Reviewed

Jun Egawa, Satoshi Hoya, Yuichiro Watanabe, Ayako Nunokawa, Masako Shibuya, Masashi Ikeda, Emiko Inoue, Shujiro Okuda, Kenji Kondo, Takeo Saito, Naoshi Kaneko, Tatsuyuki Muratake, Hirofumi Igeta, Nakao Iwata, Toshiyuki Someya

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 171 ( 6 ) 797 - 805 2016.9

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DOI： 10.1002/ajmg.b.32444

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Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up study in a Japanese population Reviewed

Yuichiro Watanabe, Ayako Nunokawa, Masako Shibuya, Masashi Ikeda, Akitoyo Hishimoto, Kenji Kondo, Jun Egawa, Naoshi Kaneko, Tatsuyuki Muratake, Takeo Saito, Satoshi Okazaki, Ayu Shimasaki, Hirofumi Igeta, Emiko Inoue, Satoshi Hoya, Takuro Sugai, Ichiro Sora, Nakao Iwata, Toshiyuki Someya

PSYCHIATRY RESEARCH 235 13 - 18 2016.1

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DOI： 10.1016/j.psychres.2015.12.011

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Resequencing and Association Analysis of CLN8 with Autism Spectrum Disorder in a Japanese Population Reviewed

Emiko Inoue, Yuichiro Watanabe, Jingrui Xing, Itaru Kushima, Jun Egawa, Shujiro Okuda, Satoshi Hoya, Takashi Okada, Yota Uno, Kanako Ishizuka, Atsunori Sugimoto, Hirofumi Igeta, Ayako Nunokawa, Toshiro Sugiyama, Norio Ozaki, Toshiyuki Someya

PLOS ONE 10 ( 12 ) e0144624 2015.12

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DOI： 10.1371/journal.pone.0144624

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Association analysis of the HLA-DRB1*01 and HLA-DRB1*04 with schizophrenia by tag SNP genotyping in the Japanese population Reviewed

Woraphat Ratta-Apha, Shuken Boku, Kentaro Mouri, Satoshi Okazaki, Ikuo Otsuka, Ichiro Sora, Akitoyo Hishimoto, Yuichiro Watanabe, Ayako Nunokawa, Toshiyuki Someya, Osamu Shirakawa

PSYCHIATRY RESEARCH 229 ( 1-2 ) 627 - 628 2015.9

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DOI： 10.1016/j.psychres.2015.07.016

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Whole-exome sequencing in a family with a monozygotic twin pair concordant for autism spectrum disorder and a follow-up study Reviewed

Jun Egawa, Yuichiro Watanabe, Atsunori Sugimoto, Ayako Nunokawa, Masako Shibuya, Hirofumi Igeta, Emiko Inoue, Satoshi Hoya, Naoki Orime, Taketsugu Hayashi, Toshiro Sugiyama, Toshiyuki Someya

PSYCHIATRY RESEARCH 229 ( 1-2 ) 599 - 601 2015.9

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DOI： 10.1016/j.psychres.2015.07.018

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Rare heterozygous truncating variations and risk of autism spectrum disorder: Whole-exome sequencing of a multiplex family and follow-up study in a Japanese population Reviewed

Emiko Inoue, Yuichiro Watanabe, Jun Egawa, Atsunori Sugimoto, Ayako Nunokawa, Masako Shibuya, Hirofumi Igeta, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 69 ( 8 ) 472 - 476 2015.8

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DOI： 10.1111/pcn.12274

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Assessment of copy number variations in the brain genome of schizophrenia patients Reviewed

Miwako Sakai, Yuichiro Watanabe, Toshiyuki Someya, Kazuaki Araki, Masako Shibuya, Kazuhiro Niizato, Kenichi Oshima, Yasuto Kunii, Hirooki Yabe, Junya Matsumoto, Akira Wada, Mizuki Hino, Takeshi Hashimoto, Akitoyo Hishimoto, Noboru Kitamura, Shuji Iritani, Osamu Shirakawa, Kiyoshi Maeda, Akinori Miyashita, Shin-ichi Niwa, Hitoshi Takahashi, Akiyoshi Kakita, Ryozo Kuwano, Hiroyuki Nawa

MOLECULAR CYTOGENETICS 8 46 2015.7

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DOI： 10.1186/s13039-015-0144-5

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高校生に対するシミュレータ実習を含む体験講座の効果

伊藤正洋, 鈴木利哉, 渡部雄一郎, 赤石隆夫, 井口清太郎, 土田正則, 佐藤昇, 竹林浩秀, 牛木辰男

日本シミュレーション医療教育学会雑誌 3 17 - 20 2015.6

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DRD2 Ser311Cys Polymorphism and Risk of Schizophrenia Reviewed

Yuichiro Watanabe, Masako Shibuya, Toshiyuki Someya

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 168 ( 3 ) 224 - 228 2015.4

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DOI： 10.1002/ajmg.b.32303

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Resequencing and association analysis of OXTR with autism spectrum disorder in a Japanese population Reviewed

Jun Egawa, Yuichiro Watanabe, Masako Shibuya, Taro Endo, Atsunori Sugimoto, Hirofumi Igeta, Ayako Nunokawa, Emiko Inoue, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 69 ( 3 ) 131 - 135 2015.3

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DOI： 10.1111/pcn.12205

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Novel Rare Missense Variations and Risk of Autism Spectrum Disorder: Whole-Exome Sequencing in Two Families with Affected Siblings and a Two-Stage Follow-Up Study in a Japanese Population Reviewed

Jun Egawa, Yuichiro Watanabe, Chenyao Wang, Emiko Inoue, Atsunori Sugimoto, Toshiro Sugiyama, Hirofumi Igeta, Ayako Nunokawa, Masako Shibuya, Itaru Kushima, Naoki Orime, Taketsugu Hayashi, Takashi Okada, Yota Uno, Norio Ozaki, Toshiyuki Someya

PLOS ONE 10 ( 3 ) e0119413 2015.3

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DOI： 10.1371/journal.pone.0119413

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Association analysis of the Cadherin13 gene with schizophrenia in the Japanese population. Reviewed International journal

Ikuo Otsuka, Yuichiro Watanabe, Akitoyo Hishimoto, Shuken Boku, Kentaro Mouri, Kyoichi Shiroiwa, Satoshi Okazaki, Ayako Nunokawa, Osamu Shirakawa, Toshiyuki Someya, Ichiro Sora

Neuropsychiatric disease and treatment 11 1381 - 93 2015

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BACKGROUND: Cadherin13 (CDH13) is a glycosylphosphatidylinositol-anchored cell adhesion molecule that plays a crucial role in morphogenesis and the maintenance of neuronal circuitry. CDH13 has been implicated in the susceptibility to a variety of psychiatric diseases. A recent genome-wide association study using Danish samples showed, for the first time, the involvement of a single nucleotide polymorphism (SNP) of CDH13 (intronic SNP rs8057927) in schizophrenia. Here, we investigated the association between other SNPs of CDH13 and schizophrenia and tried to replicate the association for the SNP of rs8057927, in the Japanese population. METHODS: Using TaqMan(®) SNP genotyping assays, five tag SNPs (rs12925602, rs7193788, rs736719, rs6565051, and rs7204454) in the promoter region of CDH13 were examined for their association with schizophrenia in two independent samples. The first sample comprised 665 patients and 760 controls, and the second sample comprised 677 patients and 667 controls. One tag SNP for rs8057927 was also examined for the association with schizophrenia in the first sample set. RESULTS: A GACAG haplotype of the five SNPs in the promoter region of CDH13 was significantly associated with schizophrenia in the first sample set (P=0.016 and corrected P=0.098). A combined analysis of the GACAG haplotype with the second sample set enhanced the significance (P=0.0026 and corrected P=0.021). We found no association between rs8057927 and schizophrenia in the first sample set. CONCLUSION: Our results suggest that CDH13 may contribute to the genetic risk of schizophrenia. Further replication on the association of CDH13 with schizophrenia and functional studies are required to confirm the current findings.

DOI： 10.2147/NDT.S84736

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統合失調症の分子病態解明を目指して

渡部雄一郎

新潟県医師会報 ( 776 ) 2 - 7 2014.11

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Association analysis of putative cis-acting polymorphisms of interleukin-19 gene with schizophrenia Reviewed

Satoshi Okazaki, Yuichiro Watanabe, Akitoyo Hishimoto, Toru Sasada, Kentaro Mouri, Kyoichi Shiroiwa, Noriomi Eguchi, Woraphat Ratta-Apha, Ikuo Otsuka, Ayako Nunokawa, Naoshi Kaneko, Masako Shibuya, Toshiyuki Someya, Osamu Shirakawa, Ichiro Sora

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 50 151 - 156 2014.4

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DOI： 10.1016/j.pnpbp.2013.12.006

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A rare MIR138-2 gene variation is associated with schizophrenia in a Japanese population Reviewed

Yuichiro Watanabe, Masako Shibuya, Ayako Nunokawa, Naoshi Kaneko, Hirofumi Igeta, Jun Egawa, Toshiyuki Someya, Akitoyo Hishimoto, Kentaro Mouri, Ichiro Sora

PSYCHIATRY RESEARCH 215 ( 3 ) 801 - 802 2014.3

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DOI： 10.1016/j.psychres.2013.12.029

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The cardiomyopathy-associated 5 (CMYA5) gene and risk of schizophrenia: Meta-analysis of rs3828611 and rs4704591 in East Asian populations Reviewed

Yuichiro Watanabe, Masako Shibuya, Toshiyuki Someya

Asian Journal of Psychiatry 7 ( 1 ) 95 - 96 2014.2

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DOI： 10.1016/j.ajp.2013.10.013

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Molecular Pathology of Schizophrenia

Watanabe Yuichiro

新潟医学会雑誌 128 ( 1 ) 7 - 12 2014.1

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統合失調症は複数の遺伝要因と環境要因が相互に影響し合って発症する複雑な脳疾患であると考えられている. 統合失調症の分子病態はいまだ明らかでないが, 筆者らはその一端を解明しつつある. 統合失調症のサイトカイン仮説に基づいて, 統合失調症患者の死後脳や末梢血におけるサイトカイン発現異常を明らかにするとともに, 高い妥当性を有する統合失調症の動物モデルとして新生仔期サイトカイン投与動物を作成した. また, ゲノム解析により疾患感受性座位を同定し, ごく一部ではあるが遺伝要因を明らかにした. さらに, 統合失調症の血液検査キットの開発を目指して, 末梢血トランスクリプトーム解析に基づく診断分類予測モデルを構築し, このモデルにより高い感度・特異度をもって患者群と対照群を判別できることを示した. 統合失調症の分子病態を完全に解明し, 妥当性の高い診断法や根治的な治療法の開発につなげるために, 今後も研究を進めていくことが必要である.

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Interleukin 1 beta gene and risk of schizophrenia: detailed case-control and family-based studies and an updated meta-analysis Reviewed

Masako Shibuya, Yuichiro Watanabe, Ayako Nunokawa, Jun Egawa, Naoshi Kaneko, Hirofumi Igeta, Toshiyuki Someya

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL 29 ( 1 ) 31 - 37 2014.1

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DOI： 10.1002/hup.2365

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Possible association between the oxytocin receptor gene and N-acetylaspartate of the right medial temporal lobe in autism spectrum disorders Reviewed

Jun Egawa, Yuichiro Watanabe, Taro Endo, Hideaki Kitamura, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 68 ( 1 ) 83 - 83 2014.1

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DOI： 10.1111/pcn.12081

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An Evaluation of Association between a Novel Hippocampal Biology Related SNP (rs7294919) and Schizophrenia Reviewed

Jiewei Liu, Shusuke Numata, Masashi Ikeda, Yuichiro Watanabe, Xue-bin Zheng, Xiongjian Luo, Makoto Kinoshita, Ayako Nunokawa, Toshiyuki Someya, Tetsuro Ohmori, Jin-xin Bei, Siow-Ann Chong, Jimmy Lee, Zhiqiang Li, Jianjun Liu, Nakao Iwata, Yongyong Shi, Ming Li, Bing Su

PLOS ONE 8 ( 11 ) e80696 2013.11

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DOI： 10.1371/journal.pone.0080696

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Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia. Reviewed International journal

Yuichiro Watanabe, Yoshimi Iijima, Jun Egawa, Ayako Nunokawa, Naoshi Kaneko, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Hiroshi Kunugi, Masanari Itokawa, Tsukasa Sasaki, Norio Ozaki, Ryota Hashimoto, Masako Shibuya, Hirofumi Igeta, Toshiyuki Someya

Schizophrenia research 150 ( 2-3 ) 596 - 7 2013.11

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DOI： 10.1016/j.schres.2013.08.028

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Association of rs2129575 in the tryptophan hydroxylase 2 gene with clinical phenotypes of autism spectrum disorders Reviewed

Jun Egawa, Yuichiro Watanabe, Taro Endo, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 67 ( 6 ) 457 - 458 2013.9

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DOI： 10.1111/pcn.12080

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An association analysis of the cardiomyopathy-associated 5 (CMYA5) gene with schizophrenia in a Japanese population Reviewed

Masaomi Furukawa, Mamoru Tochigi, Takeshi Otowa, Tadao Arinami, Toshiya Inada, Hiroshi Ujike, Yuichiro Watanabe, Nakao Iwata, Masanari Itokawa, Hiroshi Kunugi, Ryota Hashimoto, Norio Ozaki, Chihiro Kakiuchi, Kiyoto Kasai, Tsukasa Sasaki

PSYCHIATRIC GENETICS 23 ( 4 ) 179 - 180 2013.8

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DOI： 10.1097/YPG.0b013e328360c8be

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Stigma toward schizophrenia among parents of high school students. Reviewed International journal

Yoshii H, Watanabe Y, Mazumder AH, Kitamura H, Akazawa K

Global journal of health science 5 ( 6 ) 46 - 53 2013.8

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Stigma toward schizophrenia is an important area of research as it is frequently a barrier to early intervention. This study attempted to identify factors underlying stigma in Japan. Because even adolescents can develop schizophrenia, 357 Japanese parents of high school students were enrolled. All parents lived outside the areas affected by the Tohoku earthquake that occurred on March 11, 2011 (ie, parts of Iwate, Miyagi, and Fukushima prefectures). Factor analysis using the Link Devaluation-Discrimination Measure identified two factors: comparison with an able-bodied person and non-comparison with an able-bodied person. Regression analysis revealed that family structure had independent effects on factor 2 (p <0.05), and ANOVA showed that education had independent effects on factor 2 (p<0.05). These results suggest that education programs that seek to counteract stigma should target curricula in high schools and vocational schools.

DOI： 10.5539/gjhs.v5n6p46

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Association between OXTR and clinical phenotypes of autism spectrum disorders Reviewed

Jun Egawa, Yuichiro Watanabe, Taro Endo, Ryu Tamura, Toshiyuki Someya, Yuichiro Watanabe, Naio Masuzawa

PSYCHIATRY RESEARCH 208 ( 1 ) 99 - 100 2013.6

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DOI： 10.1016/j.psychres.2012.11.007

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Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population Reviewed

M. Ikeda, B. Aleksic, K. Yamada, Y. Iwayama-Shigeno, K. Matsuo, S. Numata, Y. Watanabe, T. Ohnuma, T. Kaneko, Y. Fukuo, T. Okochi, T. Toyota, E. Hattori, S. Shimodera, M. Itakura, A. Nunokawa, N. Shibata, H. Tanaka, H. Yoneda, H. Arai, T. Someya, T. Ohmori, T. Yoshikawa, N. Ozaki, N. Iwata

MOLECULAR PSYCHIATRY 18 ( 6 ) 636 - 638 2013.6

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DOI： 10.1038/mp.2012.74

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Genome-wide association study of schizophrenia using microsatellite markers in the Japanese population Reviewed

Hiroki Shibata, Ken Yamamoto, Zhu Sun, Akira Oka, Hidetoshi Inoko, Tadao Arinami, Toshiya Inada, Hiroshi Ujike, Masanari Itokawa, Mamoru Tochigi, Yuichiro Watanabe, Toshiyuki Someya, Hiroshi Kunugi, Tatsuyo Suzuki, Nakao Iwata, Norio Ozaki, Yasuyuki Fukumaki

PSYCHIATRIC GENETICS 23 ( 3 ) 117 - 123 2013.6

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DOI： 10.1097/YPG.0b013e32835fe4f1

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Resequencing and association analysis of MIR137 with schizophrenia in a Japanese population Reviewed

Jun Egawa, Ayako Nunokawa, Masako Shibuya, Yuichiro Watanabe, Naoshi Kaneko, Hirofumi Igeta, Toshiyuki Someya

Psychiatry and Clinical Neurosciences 67 ( 4 ) 277 - 279 2013.5

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DOI： 10.1111/pcn.12047

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Association of the BDNFC270T polymorphism with schizophrenia: Updated meta-analysis Reviewed

Yuichiro Watanabe, Ayako Nunokawa, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 67 ( 2 ) 123 - 125 2013.2

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DOI： 10.1111/pcn.12018

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A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients Reviewed

Irwan Supriyanto, Yuichiro Watanabe, Kentaro Mouri, Kyoichi Shiroiwa, Woraphat Ratta-Apha, Masakuni Yoshida, Genki Tamiya, Toru Sasada, Noriomi Eguchi, Kenji Okazaki, Osamu Shirakawa, Toshiyuki Someya, Akitoyo Hishimoto

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 40 347 - 352 2013.1

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DOI： 10.1016/j.pnpbp.2012.11.002

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Pharmacogenomics in Psychiatric Disorders Reviewed

Y.W. Francis Lam, Naoki Fukui, Takuro Sugai, Junzo Watanabe, Yuichiro Watanabe, Yutato Suzuki, Toshiyuki Someya

Pharmacogenomics 191 - 223 2013

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DOI： 10.1016/B978-0-12-391918-2.00006-8

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Oxytocin receptor (OXTR) gene and risk of schizophrenia: Case-control and family-based analyses and meta-analysis in a Japanese population Reviewed

Yuichiro Watanabe, Naoshi Kaneko, Ayako Nunokawa, Masako Shibuya, Jun Egawa, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 66 ( 7 ) 622 - 622 2012.12

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DOI： 10.1111/j.1440-1819.2012.02396.x

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Supportive evidence for the association between the Gln2Pro polymorphism in the SIGMAR1 gene and schizophrenia in the Japanese population: A case-control study and an updated meta-analysis Reviewed

Yuichiro Watanabe, Ayako Nunokawa, Naoshi Kaneko, Masako Shibuya, Jun Egawa, Toshiyuki Someya

SCHIZOPHRENIA RESEARCH 141 ( 2-3 ) 279 - 280 2012.11

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DOI： 10.1016/j.schres.2012.06.043

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薬物治療の根拠と理論薬物治療と生物学的・薬理学的理解とのクロストーク

渡部雄一郎, 染矢俊幸

臨床精神薬理 15 ( 8 ) 1267 - 1275 2012.8

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Social Distance toward schizophrenia among parents of adolescents Reviewed

Yoshii H, Watanabe Y, Kitamura H, Ling Y, Akazawa K

Health 4 ( 7 ) 386 - 391 2012.7

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DOI： 10.4236/health.2012.47061

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Factors associated with an absence of effect of an education program for improving knowledge of schizophrenia. Reviewed

Yoshii H, Watanabe Y, Kitamura H, Sakai Y, Akazawa K

Global journal of health science 4 ( 4 ) 42 - 47 2012.5

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DOI： 10.5539/gjhs.v4n4p42

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Exploration of a possible association between the tryptophan hydroxylase 2 (TPH2) gene and panic symptoms induced by carbon dioxide in healthy individuals Reviewed

Ryo Abe, Yuichiro Watanabe, Akira Tachibana, Ayako Nunokawa, Masanobu Shindo, Naoya Hasegawa, Toshiyuki Someya

PSYCHIATRY RESEARCH 197 ( 3 ) 358 - 359 2012.5

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DOI： 10.1016/j.psychres.2011.11.005

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A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population Reviewed

Yuichiro Watanabe, Jun Egawa, Yoshimi Iijima, Ayako Nunokawa, Naoshi Kaneko, Masako Shibuya, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Mamoru Tochigi, Hiroshi Kunugi, Masanari Itokawa, Norio Ozaki, Ryota Hashimoto, Toshiyuki Someya

SCHIZOPHRENIA RESEARCH 137 ( 1-3 ) 264 - 266 2012.5

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DOI： 10.1016/j.schres.2012.01.034

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A detailed association analysis between the tryptophan hydroxylase 2 (TPH2) gene and autism spectrum disorders in a Japanese population Reviewed

Jun Egawa, Yuichiro Watanabe, Ayako Nunokawa, Taro Endo, Naoshi Kaneko, Ryu Tamura, Toshiro Sugiyama, Toshiyuki Someya

PSYCHIATRY RESEARCH 196 ( 2-3 ) 320 - 322 2012.4

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DOI： 10.1016/j.psychres.2011.09.001

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Association of SNPs linked to increased expression of SLC1A1 with schizophrenia. Reviewed International journal

Yasue Horiuchi, Syuhei Iida, Minori Koga, Hiroki Ishiguro, Yoshimi Iijima, Toshiya Inada, Yuichiro Watanabe, Toshiyuki Someya, Hiroshi Ujike, Nakao Iwata, Norio Ozaki, Hiroshi Kunugi, Mamoru Tochigi, Masanari Itokawa, Makoto Arai, Kazuhiro Niizato, Shuji Iritani, Akiyoshi Kakita, Hitoshi Takahashi, Hiroyuki Nawa, Tadao Arinami

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 159B ( 1 ) 30 - 7 2012.1

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Glutamate is one of the key molecules involved in signal transduction in the brain, and dysfunction of glutamate signaling could be linked to schizophrenia. The SLC1A1 gene located at 9p24 encodes the glutamate transporter EAAT3/EAAC1. To investigate the association between the SLC1A1 gene and schizophrenia in the Japanese population, we genotyped 19 tagging single nucleotide polymorphisms (tagSNPs) in the SLC1A1 gene in 576 unrelated individuals with schizophrenia and 576 control subjects followed by replication in an independent case-control study of 1,344 individuals with schizophrenia and 1,344 control subjects. In addition, we determined the boundaries of the copy number variation (CNV) region in the first intron (Database of Genomic Variants, chr9:4516796-4520549) and directly genotyped the CNV because of significant deviation from the Hardy-Weinberg equilibrium. The CNV was not associated with schizophrenia. Four SNPs showed a possible association with schizophrenia in the screening subjects and the associations were replicated in the same direction (nominal allelic P < 0.05), and, among them, an association with rs7022369 was replicated even after Bonferroni correction (allelic nominal P = 5 × 10(-5) , allelic corrected P = 2.5 × 10(-4) , allelic odds ratio, 1.30; 95% CI: 1.14-1.47 in the combined subjects). Expression analysis quantified by the real-time quantitative polymerase chain reaction in the postmortem prefrontal cortex of 43 Japanese individuals with schizophrenia and 11 Japanese control subjects revealed increased SLC1A1 expression levels in individuals homozygous for the rs7022369 risk allele (P = 0.003). Our findings suggest the involvement of SLC1A1 in the pathogenesis of schizophrenia.

DOI： 10.1002/ajmg.b.31249

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Effect of an education program on improving help-seeking among parents of junior and senior high school students in Japan. Reviewed

Yoshii H, Watanabe Y, Kitamura H, Nan Z, Akazawa K

Global journal of health science 4 ( 1 ) 33 - 41 2011.12

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DOI： 10.5539/gjhs.v4n1p33

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Positive Association of Phencyclidine-Responsive Genes, PDE4A and PLAT, With Schizophrenia Reviewed

Xiangdong Deng, Hiromi Takaki, Lixiang Wang, Tosihide Kuroki, Tatsuo Nakahara, Kijiro Hashimoto, Hideaki Ninomiya, Tadao Arinami, Toshiya Inada, Hiroshi Ujike, Masanari Itokawa, Mamoru Tochigi, Yuichiro Watanabe, Toshiyuki Someya, Hiroshi Kunugi, Nakao Iwata, Norio Ozaki, Hiroki Shibata, Yasuyuki Fukumaki

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 156B ( 7 ) 850 - 858 2011.12

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DOI： 10.1002/ajmg.b.31233

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統合失調症とマイクロRNA (特集精神疾患とマイクロRNA)

渡部雄一郎, 武井延之, 那波宏之

分子精神医学 11 ( 3 ) 179 - 184 2011.7

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Functional Polymorphism in the GPR55 Gene is Associated With Anorexia Nervosa Reviewed

Hiroki Ishiguro, Emmanuel S. Onaivi, Yasue Horiuchi, Keiko Imai, Gen Komaki, Toshio Ishikawa, Mari Suzuki, Yuichiro Watanabe, Tetsuya Ando, Susumu Higuchi, Tadao Arinami

SYNAPSE 65 ( 2 ) 103 - 108 2011.2

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DOI： 10.1002/syn.20821

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Stigma toward schizophrenia among parents of junior and senior high school students in Japan Reviewed

Hatsumi Yoshii, Yuichiro Watanabe, Hideaki Kitamura, Zhang Nan, Kouhei Akazawa

BMC Research Notes 4 558 2011

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DOI： 10.1186/1756-0500-4-558

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Reduced thalamus volume in non-right-handed male patients with autism spectrum disorders Reviewed

Jun Egawa, Yuichiro Watanabe, Hideaki Kitamura, Taro Endo, Ryu Tamura, Naoya Hasegawa, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 65 ( 4 ) 395 - 395 2011

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DOI： 10.1111/j.1440-1819.2011.02210.x

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A case-control study and meta-analysis of association between a common copy number variation of the glutathione S-transferase mu I (GSTM1) gene and schizophrenia Reviewed

Yuichiro Watanabe, Ayako Nunokawa, Naoshi Kaneko, Toshiyuki Someya

SCHIZOPHRENIA RESEARCH 124 ( 1-3 ) 236 - 237 2010.12

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DOI： 10.1016/j.schres.2010.08.001

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An association study between the dymeclin gene and schizophrenia in the Japanese population Reviewed

Saori Yazaki, Minori Koga, Hiroki Ishiguro, Toshiya Inada, Hiroshi Ujike, Masanari Itokawa, Takeshi Otowa, Yuichiro Watanabe, Toshiyuki Someya, Nakao Iwata, Hiroshi Kunugi, Norio Ozaki, Tadao Arinami

JOURNAL OF HUMAN GENETICS 55 ( 9 ) 631 - 634 2010.9

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DOI： 10.1038/jhg.2010.72

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Psychiatric disorders

渡部雄一郎, 染矢俊幸

Japanese journal of clinical medicine 68 ( 0 ) 402 - 405 2010.8

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Supportive Evidence for Reduced Expression of GNB1L in Schizophrenia Reviewed

Hiroki Ishiguro, Minori Koga, Yasue Horiuchi, Emiko Noguchi, Miyuki Morikawa, Yoshimi Suzuki, Makoto Arai, Kazuhiro Niizato, Shyuji Iritani, Masanari Itokawa, Toshiya Inada, Nakao Iwata, Norio Ozaki, Hiroshi Ujike, Hiroshi Kunugi, Tsukasa Sasaki, Makoto Takahashi, Yuichiro Watanabe, Toshiyuki Someya, Akiyoshi Kakita, Hitoshi Takahashi, Hiroyuki Nawa, Tadao Arinami

SCHIZOPHRENIA BULLETIN 36 ( 4 ) 756 - 765 2010.7

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DOI： 10.1093/schbul/sbn160

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Measurement and comparison of serum neuregulin 1 immunoreactivity in control subjects and patients with schizophrenia: an influence of its genetic polymorphism Reviewed

M. Shibuya, E. Komi, R. Wang, T. Kato, Y. Watanabe, M. Sakai, M. Ozaki, T. Someya, H. Nawa

JOURNAL OF NEURAL TRANSMISSION 117 ( 7 ) 887 - 895 2010.7

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DOI： 10.1007/s00702-010-0418-3

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Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures Reviewed

Makoto Takahashi, Hiroshi Hayashi, Yuichiro Watanabe, Kazushi Sawamura, Naoki Fukui, Junzo Watanabe, Tsuyoshi Kitajima, Yoshio Yamanouchi, Nakao Iwata, Katsuyoshi Mizukami, Takafumi Hori, Kazutaka Shimoda, Hiroshi Ujike, Norio Ozaki, Kentarou Iijima, Kazuo Takemura, Hideyuki Aoshima, Toshiyuki Someya

SCHIZOPHRENIA RESEARCH 119 ( 1-3 ) 210 - 218 2010.6

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DOI： 10.1016/j.schres.2009.12.024

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Cytokine hypothesis of schizophrenia pathogenesis: evidence from human studies and animal models. Reviewed

Watanabe Yuichiro, Someya Toshiyuki, Nawa Hiroyuki

Psychiatry Clin Neurosci 64 ( 3 ) 217 - 230 2010.6

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DOI： 10.1111/j.1440-1819.2010.02094.x

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Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia Reviewed

Minori Koga, Hiroki Ishiguro, Yasue Horiuchi, Toshiya Inada, Hiroshi Ujike, Masanari Itokawa, Takeshi Otowa, Yuichiro Watanabe, Toshiyuki Someya, Tadao Arinami

PSYCHIATRIC GENETICS 20 ( 3 ) 123 - 125 2010.6

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DOI： 10.1097/YPG.0b013e32833a1f52

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Brain cannabinoid CB2 receptor in schizophrenia. Reviewed

Ishiguro Hiroki, Horiuchi Yasue, Ishikawa Maya, Koga Minori, Imai Keiko, Suzuki Yoshimi, Morikawa Miyuki, Inada Toshiya, Watanabe Yuichiro, Takahashi Makoto, Someya Toshiyuki, Ujike Hiroshi, Iwata Nakao, Ozaki Norio, Onaivi Emmanuel S, Kunugi Hiroshi, Sasaki Tsukasa, Itokawa Masanari, Arai Makoto, Niizato Kazuhiro, Iritani Shyuji, Naka Izumi, Ohashi Jun, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Arinami Tadao

Biol Psychiatry 67 ( 10 ) 974 - 982 2010.5

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DOI： 10.1016/j.biopsych.2009.09.024

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Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: A three-stage case-control association study Reviewed

Hideki Amagane, Yuichiro Watanabe, Naoshi Kaneko, Ayako Nunokawa, Tatsuyuki Muratake, Hiroki Ishiguro, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Hiroshi Kunugi, Tsukasa Sasaki, Ryota Hashimoto, Masanari Itokawa, Norio Ozaki, Toshiyuki Someya

SCHIZOPHRENIA RESEARCH 118 ( 1-3 ) 106 - 112 2010.5

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DOI： 10.1016/j.schres.2010.01.023

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A case-control association analysis of CABIN1 with schizophrenia in a Japanese population Reviewed

Yuichiro Watanabe, Ayako Nunokawa, Naoshi Kaneko, Toshiyuki Someya

JOURNAL OF HUMAN GENETICS 55 ( 3 ) 179 - 181 2010.3

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DOI： 10.1038/jhg.2009.136

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Donepezil服用後にパーキンソニズムが悪化したレビー小体型認知症の1例

常山暢人, 渡部雄一郎, 澤村一司, 染矢俊幸

臨床精神薬理 13 ( 2 ) 397 - 402 2010.2

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The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: Case-control studies and an updated meta-analysis Reviewed

Ayako Nunokawa, Yuichiro Watanabe, Naoshi Kaneko, Takuro Sugai, Saori Yazaki, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Hiroshi Kunugi, Tsukasa Sasaki, Masanari Itokawa, Norio Ozaki, Ryota Hashimoto, Toshiyuki Someya

SCHIZOPHRENIA RESEARCH 116 ( 1 ) 61 - 67 2010.1

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DOI： 10.1016/j.schres.2009.10.016

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Cytokine hypothesis of schizophrenia pathogenesis: Evidence from human studies and animal models Reviewed

Yuichiro Watanabe, Toshiyuki Someya, Hiroyuki Nawa

Psychiatry and Clinical Neurosciences 64 ( 3 ) 217 - 230 2010

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DOI： 10.1111/j.1440-1819.2010.02094.x

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Preliminary Genome-Wide Association Study of Bipolar Disorder in the Japanese Population Reviewed

Eiji Hattori, Tomoko Toyota, Yuichi Ishitsuka, Yoshimi Iwayama, Kazuo Yamada, Hiroshi Ujike, Yukitaka Morita, Masafumi Kodama, Kenji Nakata, Yoshio Minabe, Kazuhiko Nakamura, Yasuhide Iwata, Nori Takei, Norio Mori, Hiroshi Naitoh, Yoshio Yamanouchi, Nakao Iwata, Norio Ozaki, Tadafumi Kato, Toru Nishikawa, Atsushi Kashiwa, Mika Suzuki, Kunihiko Shioe, Manabu Shinohara, Masami Hirano, Shinichiro Nanko, Akihisa Akahane, Mikako Ueno, Naoshi Kaneko, Yuichiro Watanabe, Toshiyuki Someya, Kenji Hashimoto, Masaomi Iyo, Masanari Itokawa, Makoto Arai, Masahiro Nankai, Toshiya Inada, Sumiko Yoshida, Hiroshi Kunugi, Michiko Nakamura, Yoshimi Iijima, Yuji Okazaki, Teruhiko Higuchi, Takeo Yoshikawa

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 150B ( 8 ) 1110 - 1117 2009.12

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DOI： 10.1002/ajmg.b.30941

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モデル動物を用いた中枢神経系機能性疾患の病態解析モデル動物を用いた統合失調症病態解析

渡部雄一郎, 那波宏之, 染矢俊幸

脳と精神の医学 20 ( 3 ) 213 - 220 2009.9

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DOI： 10.11249/jsbp.20.213

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Schizophrenia and genomics

渡部雄一郎, 布川綾子, 金子尚史

Japanese journal of clinical psychiatry 38 ( 8 ) 1031 - 1037 2009.8

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A two-stage case-control association study of PADI2 with schizophrenia Reviewed

Yuichiro Watanabe, Ayako Nunokawa, Naoshi Kaneko, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Hiroshi Kunugi, Masanari Itokawa, Takeshi Otowa, Norio Ozaki, Toshiyuki Someya

JOURNAL OF HUMAN GENETICS 54 ( 7 ) 430 - 432 2009.7

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DOI： 10.1038/jhg.2009.52

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Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia Reviewed

Minori Koga, Hiroki Ishiguro, Saori Yazaki, Yasue Horiuchi, Makoto Arai, Kazuhiro Niizato, Shuji Iritani, Masanari Itokawa, Toshiya Inada, Nakao Iwata, Norio Ozaki, Hiroshi Ujike, Hiroshi Kunugi, Tsukasa Sasaki, Makoto Takahashi, Yuichiro Watanabe, Toshiyuki Someya, Akiyoshi Kakita, Hitoshi Takahashi, Hiroyuki Nawa, Christian Muchardt, Moshe Yaniv, Tadao Arinami

HUMAN MOLECULAR GENETICS 18 ( 13 ) 2483 - 2494 2009.7

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DOI： 10.1093/hmg/ddp166

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個別化医療臨床的観点から 6 精神疾患とゲノム多様性

布川綾子, 渡部雄一郎, 染矢俊幸

治療学 43 ( 3 ) 307 - 311 2009.3

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Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia Reviewed

Yuichiro Watanabe, Ayako Nunokawa, Naoshi Kaneko, Tatsuyuki Muratake, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Hiroshi Kunugi, Masanari Itokawa, Takeshi Otowa, Norio Ozaki, Toshiyuki Someya

JOURNAL OF HUMAN GENETICS 54 ( 1 ) 62 - 65 2009.1

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DOI： 10.1038/jhg.2008.4

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Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia Reviewed

Minori Koga, Hiroki Ishiguro, Saori Yazaki, Yasue Horiuchi, Makoto Arai, Kazuhiro Niizato, Shuji Iritani, Masanari Itokawa, Toshiya Inada, Nakao Iwata, Norio Ozaki, Hiroshi Ujike, Hiroshi Kunugi, Tsukasa Sasaki, Makoto Takahashi, Yuichiro Watanabe, Toshiyuki Someya, Akiyoshi Kakita, Hitoshi Takahashi, Hiroyuki Nawa, Christian Muchardt, Moshe Yaniv, Tadao Arinami

Human Molecular Genetics 18 ( 13 ) 2483 - 2494 2009

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DOI： 10.1093/hmg/ddp166

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Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia Reviewed

Hiroki Ishiguro, Keiko Imai, Minori Koga, Yasue Horiuchi, Toshiya Inada, Nakao Iwata, Norio Ozaki, Hiroshi Ujike, Masanari Itokawa, Hiroshi Kunugi, Tsukasa Sasaki, Yuichiro Watanabe, Toshiyuki Someya, Tadao Arinami

PSYCHIATRIC GENETICS 18 ( 5 ) 255 - 256 2008.10

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DOI： 10.1097/YPG.0b013e328306c7dc

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Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population Reviewed

Yuichiro Watanabe, Ayako Nunokawa, Masako Shibuya, Naoshi Kaneko, Hiroyuki Nawa, Toshiyuki Someya

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 258 ( 7 ) 422 - 427 2008.10

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DOI： 10.1007/s00406-008-0813-z

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Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population. Reviewed

Watanabe Yuichiro, Nunokawa Ayako, Shibuya Masako, Kaneko Naoshi, Nawa Hiroyuki, Someya Toshiyuki

Eur Arch Psychiatry Clin Neurosci 258 ( 7 ) 422 - 427 2008.10

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DOI： 10.1007/s00406-008-0813-z

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Paroxetineとnortriptylineの薬物相互作用により錐体外路症状がみられた1例

横山裕一, 渡部雄一郎, 須貝拓朗, 福井直樹, 高橋誠, 染矢俊幸

臨床精神薬理 11 ( 7 ) 1343 - 1347 2008.7

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【脳とサイトカイン基礎と臨床】統合失調症におけるサイトカインの機能と役割

那波宏之, 渡部雄一郎, 染矢俊幸

Brain Medical 20 ( 2 ) 167 - 172 2008.6

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Large-scale case-control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia Reviewed

Ayako Nunokawa, Yuichiro Watanabe, Hideaki Kitamura, Naoshi Kaneko, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Hiroshi Kunugi, Masanari Itokawa, Norio Ozaki, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 62 ( 2 ) 239 - 240 2008.4

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DOI： 10.1111/j.1440-1819.2008.01762.x

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Association of polymorphisms in the haplotype block spanning the alternatively spliced exons of the NTNG1 gene at 1p13.3 with schizophrenia in Japanese populations Reviewed

T. Ohtsuki, Y. Horiuchi, M. Koga, H. Ishiguro, T. Inada, N. Iwata, N. Ozaki, H. Ujike, Y. Watanabe, T. Someya, T. Arinami

NEUROSCIENCE LETTERS 435 ( 3 ) 194 - 197 2008.4

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DOI： 10.1016/j.neulet.2008.02.053

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Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample Reviewed

Masashi Ikeda, Nagahide Takahashi, Shinichi Saito, Branko Aleksic, Yuichiro Watanabe, Ayako Nunokawa, Yoshio Yamanouchi, Tsuyoshi Kitajima, Yoko Kinoshita, Taro Kishi, Kunihiro Kawashima, Ryota Hashimoto, Hiroshi Ujike, Toshiya Inada, Toshiyuki Someya, Masatoshi Takeda, Norio Ozaki, Nakao Iwata

SCHIZOPHRENIA RESEARCH 101 ( 1-3 ) 1 - 8 2008.4

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DOI： 10.1016/j.schres.2008.01.010

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A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia Reviewed

Tsuyuka Ohtsuki, Minori Koga, Hiroki Ishiguro, Yasue Horiuchi, Makoto Arai, Kazuhiro Niizato, Masanari Itokawa, Toshiya Inada, Nakao Iwata, Shyuji Iritani, Norio Ozaki, Hiroshi Kunugi, Hiroshi Ujike, Yuichiro Watanabe, Toshiuki Someya, Tadao Arinami

SCHIZOPHRENIA RESEARCH 101 ( 1-3 ) 9 - 16 2008.4

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DOI： 10.1016/j.schres.2008.01.027

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Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population Reviewed

Talal Albalushi, Yasue Horiuchi, Hiroki Ishiguro, Minori Koga, Toshiya Inada, Nakao Iwata, Norio Ozaki, Hiroshi Ujike, Yuichiro Watanabe, Toshiyuki Someya, Tadao Arinami

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 147B ( 3 ) 392 - 396 2008.4

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DOI： 10.1002/ajmg.b.30610

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The tryptophan hydroxylase 1 (TPH1) gene and risk of schizophrenia: A moderate-scale case-control study and meta-analysis Reviewed

Yuichiro Watanabe, Ayako Nunokawa, Naoshi Kaneko, Toshiyuki Someya

NEUROSCIENCE RESEARCH 59 ( 3 ) 322 - 326 2007.11

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DOI： 10.1016/j.neures.2007.08.002

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Olanzapineからaripiprazoleへの置換によりメタボリックシンドロームと高プロラクチン血症が改善した統合失調症の1例

湯川尊行, 渡部雄一郎, 小泉暢大栄, 染矢俊幸

臨床精神薬理 10 ( 9 ) 1757 - 1762 2007.9

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No association between the tumor necrosis factor-alpha gene promoter polymorphisms and schizophrenia in a Japanese population Reviewed

Yuichiro Watanabe, Tatsuyuki Muratake, Naoshi Kaneko, Naoki Fukui, Yasushi Nara, Toshiyuki Someya

PSYCHIATRY RESEARCH 153 ( 1 ) 1 - 6 2007.9

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DOI： 10.1016/j.psychres.2006.03.009

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Meta-analysis of case-control association studies between the C270T polymorphism of the brain-derived neurotrophic factor gene and schizophrenia Reviewed

Yuichiro Watanabe, Ayako Nunokawa, Naoshi Kaneko, Toshiyuki Someya

SCHIZOPHRENIA RESEARCH 95 ( 1-3 ) 250 - 252 2007.9

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DOI： 10.1016/j.schres.2007.05.032

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Lack of association between the interleukin-1 gene complex and schizophrenia in a Japanese population Reviewed

Yuichiro Watanabe, Ayako Nunokawa, Naoshi Kaneko, Tatsuyuki Muratake, Masataka Koizumi, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 61 ( 4 ) 364 - 369 2007.8

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DOI： 10.1111/j.1440-1819.2007.01671.x

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No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population Reviewed

Ayako Nunokawa, Yulchiro Watanabe, Tatsuyuki Muratake, Naoshi Kaneko, Masataka Koizumi, Toshiyuki Sorneya

NEUROSCIENCE RESEARCH 58 ( 3 ) 291 - 296 2007.7

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DOI： 10.1016/j.neures.2007.03.015

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No association between the ERBB3 gene and schizophrenia in a Japanese population Reviewed

Yuichiro Watanabe, Naoki Fukui, Ayako Nunokawa, Tatsuyuki Muratake, Naoshi Kaneko, Hideaki Kitamura, Toshiyuki Someya

NEUROSCIENCE RESEARCH 57 ( 4 ) 574 - 578 2007.4

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DOI： 10.1016/j.neures.2007.01.001

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第2章特定の物質の不足ないしは過剰に疾患が由来する病態 4) 非依存性医薬品 12. 抗うつ薬に由来する病態

渡部雄一郎, 染矢俊幸

精神科治療学 21 240 - 241 2006.10

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Association study of a functional promoter polymorphism of the X-box binding protein 1 gene in Japanese patients with schizophrenia Reviewed

Yuichiro Watanabe, Naoki Fukui, Tatsuyuki Muratake, Hideki Amagane, Naoshi Kaneko, Ayako Nunokawa, Toshiyuki Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 60 ( 5 ) 633 - 635 2006.10

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DOI： 10.1111/j.1440-1819.2006.01570.x

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そこが知りたい薬物療法Q&A SSRIはQTc延長を惹起するか?

熊田智, 渡部雄一郎, 染矢俊幸

臨床精神薬理 9 ( 8 ) 1579 - 1580 2006.8

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Risperidoneからolanzapineへの置換により勃起障害が改善した統合失調症の1例

横山裕一, 渡部雄一郎, 福井直樹, 高橋誠, 染矢俊幸

臨床精神薬理 9 ( 7 ) 1425 - 1429 2006.7

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No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population Reviewed

Y Watanabe, T Muratake, N Kaneko, A Nunokawa, T Someya

SCHIZOPHRENIA RESEARCH 84 ( 1 ) 29 - 35 2006.5

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DOI： 10.1016/j.schres.2006.03.011

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神経精神症状に対してミルナシプランの単剤投与が奏効した進行性核上性麻痺の1例

横山裕一, 渡部雄一郎, 小澤鉄太郎

精神医学 48 ( 4 ) 439 - 441 2006.4

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DOI： 10.11477/mf.1405100253

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そこが知りたい薬物療法Q&A 非定型抗精神病薬は強迫症状を惹起するか?

横山裕一, 渡部雄一郎, 染矢俊幸

臨床精神薬理 9 ( 2 ) 247 - 248 2006.2

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Mania after vascular dementia in a patient with bipolar II disorder Reviewed

Y Watanabe, T Shioiri, H Kuwabara, T Someya

PSYCHIATRY AND CLINICAL NEUROSCIENCES 60 ( 1 ) 117 - 118 2006.2

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DOI： 10.1111/j.1440-1819.2006.01470.x

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Mouse schizophrenia models established with cytokines

Tsuda Noriko, Tohmi Manavu, Watanabe Yuichiro, Someya Toshiyuki, Nawa Hiroyuki

脳と精神の医学 17 ( 1 ) 53 - 58 2006

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Sustained brain-derived neurotrophic factor upregulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine Reviewed

Makoto Takahashi, Yuichiro Watanabe, Makoto Mizuno, Kenji Sakimura, Toshitaka Nabeshima, Toshiyuki Someya, Hiroyuki Nawa

NEUROSCIENCE RESEARCH 55 S12 - S12 2006

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そこが知りたい薬物療法Q&A Risperidoneは低体温を起こすか?

坂井美和子, 渡部雄一郎, 染矢俊幸

臨床精神薬理 8 ( 12 ) 1965 - 1966 2005.12

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総合病院精神科におけるコンサルテーション・リエゾン活動外来患者と入院患者の比較

坂井美和子, 渡部雄一郎, 塩入俊樹, 諸橋優子, 田中弘, 川村剛, 福島昇, 染矢俊幸

精神科治療学 20 ( 9 ) 953 - 959 2005.9

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本邦からの報告第8回操作的診断(DSMおよびICD)のアウトカム研究に果たす役割

渡部雄一郎, 染矢俊幸

Schizophrenia Front 6 ( 3 ) 209 - 212 2005.8

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第7回統合失調症の仮説とそのモデル検証炎症性サイトカインと統合失調症;複雑な環境―遺伝子相互作用

那波宏之, 津田法子, 渡部雄一郎, 任海学, 水野誠

分子精神医学 5 ( 3 ) 301 - 307 2005.7

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【精神科領域の薬学的ケア】患者を知る・くすりを知る統合失調症の病態と行動

渡部雄一郎, 染矢俊幸

薬事 47 ( 8 ) 1315 - 1318 2005.7

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Perinatal perturbation of inflammatory cytokine activities results in distinct cognitive/behavioral impairments in rodents; Implication in psychiatric diseases of neurodevelopmental origin Reviewed

H Nawa, M Tohmi, N Tsuda, Y Watanabe, T Someya, M Mizuno

SCHIZOPHRENIA BULLETIN 31 ( 2 ) 306 - 306 2005.4

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上皮成長因子ファミリーによるドパミン神経発達調節活性と認知機能障害の関連解析

岩倉百合子, 朴英善, 外山英和, 渡部雄一郎, 金善和, 水野誠, 那波宏之

精神薬療研究年報 ( 37 ) 138 - 143 2005.3

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No association of EGF polymorphism with schizophrenia in a Japanese population Reviewed

Y Watanabe, N Fukui, T Muratake, N Kaneko, T Someya

NEUROREPORT 16 ( 4 ) 403 - 405 2005.3

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DOI： 10.1097/00001756-200503150-00019

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治療薬開発の現状と見通し (〔こころの科学〕創刊20周年記念増大号) -- (特別企画統合失調症)

渡部雄一郎, 染矢俊幸

こころの科学 ( 120 ) 36 - 42 2005.3

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Risperidone投与中に水中毒から悪性症候群と横紋筋融解症を呈した統合失調症の1例

渡部雄一郎, 小林慎一, 熊谷敬一, 山本佳子, 田中敏春, 藤島直人, 内藤明彦, 染矢俊幸

臨床精神薬理 8 ( 2 ) 235 - 239 2005.2

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Perinatal inflammatory cytokine challenge results in distinct neurobehavioral alterations in rats: implication in psychiatric disorders of developmental origin Reviewed

M Tohmi, N Tsuda, Y Watanabe, A Kakita, H Nawa

NEUROSCIENCE RESEARCH 50 ( 1 ) 67 - 75 2004.9

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DOI： 10.1016/j.neures.2004.05.010

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サイトカインを用いた認知障害モデル動物;統合失調症との関連

那波宏之, 任海学, 津田法子, 渡部雄一郎, 水野誠

応用薬理 66 ( 3 ) 231 - 235 2004.7

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Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats Reviewed

Y Watanabe, S Hashimoto, A Kakita, H Takahashi, J Ko, M Mizuno, T Someya, PH Patterson, H Nawa

NEUROSCIENCE RESEARCH 48 ( 3 ) 345 - 353 2004.3

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DOI： 10.1016/j.neures.2003.12.001

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A decrease in interleukin-1 receptor antagonist expression in the prefrontal cortex of schizophrenic patients Reviewed

K Toyooka, Y Watanabe, S Iritani, E Shimizu, M Iyo, R Nakamura, K Asama, T Makifuchi, A Kakita, H Takahashi, T Someya, H Nawa

NEUROSCIENCE RESEARCH 46 ( 3 ) 299 - 307 2003.7

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DOI： 10.1016/S0168-0102(03)00093-2

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Stress vulnerability of the rats receiving neonatal administration of interleukin-1 Reviewed

Y Watanabe, M Tohmi, T Someya, H Nawa

SCHIZOPHRENIA RESEARCH 60 ( 1 ) 118 - 118 2003.3

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DOI： 10.1016/S0920-9964(03)80878-2

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Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients Reviewed

K Toyooka, K Asama, Y Watanabe, T Muratake, M Takahashi, T Someya, H Nawa

PSYCHIATRY RESEARCH 110 ( 3 ) 249 - 257 2002.7

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DOI： 10.1016/S0165-1781(02)00127-0

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修正電気けいれん療法がパーキンソン症状と遷延したうつ状態に著効した一例

阿部亮, 塩入俊樹, 渡部雄一郎, 成瀬聡, 染矢俊幸

精神科治療学 17 ( 1 ) 67 - 73 2002.1

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薬物依存症の神経科学 5. 依存性薬物と脳内サイトカイン

那波宏之, 渡部雄一郎, 任海学, 二村隆史

医学のあゆみ 199 ( 6 ) 437 - 440 2001.11

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精神疾患の分子医学基礎と臨床基礎神経栄養因子・サイトカインと精神疾患

渡部雄一郎, 那波宏之

現代医療 33 ( 11 ) 2697 - 2702 2001.11

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Zung自己記入式抑うつ評価尺度および不安評価尺度の臨床的有用性について

渡部雄一郎, 坂井美和子, 塩入俊樹, 細木俊宏, 染矢俊幸

臨床精神医学 30 ( 8 ) 991 - 996 2001.8

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神経栄養因子・サイトカインと精神疾患 (特集精神疾患の分子医学--基礎と臨床) -- (基礎)

渡部雄一郎, 那波宏之

現代医療 33 ( 11 ) 2697 - 2702 2001

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研修医を応援する処方奏効・失敗例再発をくり返す双極I型障害の1症例 lithium維持療法の困難さについて

渡部雄一郎, 塩入俊樹, 染矢俊幸

臨床精神薬理 2 ( 12 ) 1411 - 1416 1999.12

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【稀な遺伝子変異やフェノタイプから精神疾患を考える】統合失調症の稀なリスク遺伝子変異の探索

森川亮, 渡部雄一郎, 染矢俊幸

日本生物学的精神医学会誌 34 ( 4 ) 145 - 150 2023.12

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クラスター分析を用いたMother-to-Infant Bonding Scaleカットオフ値の推定

橋尻洸陽, 渡部雄一郎, 福井直樹, 茂木崇治, 小川真貴, 江川純, 榎本隆之, 染矢俊幸

新潟周産母子研究会学術講演会 33回 8 - 8 2023.7

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【精神栄養学:精神疾患を食事や栄養から考える】食事・栄養と統合失調症

渡部雄一郎, 大竹将貴, 染矢俊幸

精神科 42 ( 4 ) 463 - 469 2023.4

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統合失調症の発症に大きな効果をもつde novo変異の同定

渡部雄一郎

先進医薬研究振興財団研究成果報告集 2022年度 10 - 11 2023.3

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Mother-to-Infant Bonding Scale日本語版を用いた周産期ボンディング障害の同定とそのカットオフ値

薄田芳裕, 橋尻洸陽, 渡部雄一郎, 福井直樹, 茂木崇治, 小川真貴, 江川純, 榎本隆之, 染矢俊幸

新潟医学会雑誌 136 ( 7 ) 232 - 232 2022.7

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せん妄の改善後に緊張病が明らかとなり修正型電気けいれん療法が著効した双極I型障害の1例

大竹雅也, 茂木崇治, 渡部雄一郎, 橋尻洸陽, 薄田芳裕, 折目直樹, 大竹将貴, 根井仁平, 染矢俊幸

新潟医学会雑誌 136 ( 7 ) 231 - 231 2022.7

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前頭側頭型認知症との鑑別を要したクッシング病によるパーソナリティ変化の一例

熊谷航一郎, 大竹雅也, 横山裕一, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 136 ( 6 ) 205 - 205 2022.6

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妊産婦936人におけるHospital Anxiety and Depression Scaleの因子構造と測定不変性

茂木崇治, 小川真貴, 渡部雄一郎, 福井直樹, 橋尻洸陽, 坪谷隆介, 須貝拓朗, 江川純, 荒木理恵, 生野寿史, 山口雅幸, 西島浩二, 榎本隆之, 染矢俊幸

新潟医学会雑誌 136 ( 5 ) 169 - 170 2022.5

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Clozapine導入後の退院支援の現状と課題 2症例の経験を通じて

根井仁平, 横山航平, 坂上仁, 大竹将貴, 渡部雄一郎, 澁谷雅子, 染矢俊幸

新潟医学会雑誌 136 ( 5 ) 169 - 169 2022.5

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レビー小体病が疑われるうつ病に対して修正型電気けいれん療法を施行した1例

横山航平, 大竹将貴, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 136 ( 5 ) 165 - 165 2022.5

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日本人統合失調症におけるSETD1A遺伝子シーケンスおよび関連解析

森川亮, 渡部雄一郎, Arta Reza Kurniawan, 染矢俊幸

新潟県医師会報 ( 864 ) 8 - 9 2022.3

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ハイリスク妊婦の包括的支援における総合病院精神科の役割について

深石翔, 横山裕一, 渡部雄一郎, 横尾ゆかり, 福井直樹, 染矢俊幸

新潟医学会雑誌 135 ( 10-12 ) 249 - 249 2021.12

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向精神薬の整理により行動・心理症状と運動症状が改善したハンチントン病による認知症の1例

宮下真子, 渡部雄一郎, 本郷祥子, 小池直人, 佐治越爾, 深石翔, 三上剛明, 小野寺理, 染矢俊幸

新潟医学会雑誌 135 ( 9 ) 209 - 209 2021.9

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修正型電気けいれん療法を施行したレビー小体病が疑われるうつ病の1例

横山航平, 橋尻洸陽, 大竹将貴, 横山裕一, 渡部雄一郎, 染矢俊幸

精神神経学雑誌 ( 2021特別号 ) S550 - S550 2021.9

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自閉スペクトラム症および統合失調症におけるGAP43遺伝子シーケンス

渡部雄一郎, Arta Reza, 井上絵美子, 森川亮, 江川純, 井桁裕文, 保谷智史, 杉本篤言, Tanra Andi, 染矢俊幸

精神神経学雑誌 ( 2021特別号 ) S561 - S561 2021.9

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日本人統合失調症患者におけるSETD1A遺伝子の稀な変異の検索

森川亮, Arta Reza, 井桁裕文, 渡部雄一郎, 保谷智史, 染矢俊幸

精神神経学雑誌 ( 2021特別号 ) S561 - S561 2021.9

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前頭側頭型認知症に類似したCushing病によるパーソナリティ変化の1例

熊谷航一郎, 横山裕一, 大竹雅也, 渡部雄一郎, 染矢俊幸

精神神経学雑誌 ( 2021特別号 ) S622 - S622 2021.9

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アルツハイマー型認知症との鑑別を要したDown症候群の急性退行の1例

松木晴香, 折目直樹, 渡部雄一郎, 森川亮, 須貝拓朗, 染矢俊幸

新潟医学会雑誌 135 ( 8 ) 178 - 178 2021.8

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統合失調症罹患同胞2人とはとこ婚両親の全エクソームシークエンス

森川亮, 井桁裕文, 渡部雄一郎, 保谷智史, 染矢俊幸

新潟医学会雑誌 135 ( 7 ) 138 - 139 2021.7

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【コロナ時代の自殺対策】COVID-19パンデミックと医療従事者のメンタルヘルス

渡部雄一郎, 染矢俊幸

公衆衛生 85 ( 3 ) 156 - 159 2021.3

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統合失調症罹患状態一致一卵性双生児家系の全エクソーム解析および症例・対照研究

渡部雄一郎, 保谷智史, 布川綾子, 澁谷雅子, 井桁裕文, 森川亮, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S306 - S306 2020.9

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ラモトリギンに関連した汎血球減少を伴う薬疹型偽リンパ腫を呈した双極II型障害の1例

深石翔, 横山裕一, 三上剛明, 渡部雄一郎, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S321 - S321 2020.9

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日本人における統合失調症患者・両親トリオ32家系の全エクソーム解析

森川亮, Reza Arta Kurniawan, 保谷智史, 渡部雄一郎, 井桁裕文, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S307 - S307 2020.9

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クエチアピン単剤化により精神症状と運動症状が改善したハンチントン病による認知症の1例

宮下真子, 渡部雄一郎, 本郷祥子, 小池直人, 佐治越爾, 深石翔, 三上剛明, 小野寺理, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S313 - S313 2020.9

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統合失調症罹患同胞対・両親の全エクソームシーケンスおよびSPATA7遺伝子リシーケンスと関連解析

井桁裕文, 渡部雄一郎, 森川亮, 池田匡志, 大塚郁夫, 保谷智史, 小泉暢大栄, 江川純, 菱本明豊, 岩田仲生, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S306 - S306 2020.9

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統合失調症多発罹患家系のエクソーム解析

保谷智史, 布川綾子, 渡部雄一郎, 金子尚史, 村竹辰之, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S307 - S307 2020.9

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ラモトリギンに関連した汎血球減少を伴う薬疹型偽リンパ腫を呈した双極II型障害の1例

深石翔, 横山裕一, 三上剛明, 渡部雄一郎, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S321 - S321 2020.9

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統合失調症多発罹患家系のエクソーム解析

保谷智史, 布川綾子, 渡部雄一郎, 金子尚史, 村竹辰之, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S307 - S307 2020.9

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統合失調症罹患同胞対・両親の全エクソームシーケンスおよびSPATA7遺伝子リシーケンスと関連解析

井桁裕文, 渡部雄一郎, 森川亮, 池田匡志, 大塚郁夫, 保谷智史, 小泉暢大栄, 江川純, 菱本明豊, 岩田仲生, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S306 - S306 2020.9

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クエチアピン単剤化により精神症状と運動症状が改善したハンチントン病による認知症の1例

宮下真子, 渡部雄一郎, 本郷祥子, 小池直人, 佐治越爾, 深石翔, 三上剛明, 小野寺理, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S313 - S313 2020.9

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日本人における統合失調症患者・両親トリオ32家系の全エクソーム解析

森川亮, Reza Arta Kurniawan, 保谷智史, 渡部雄一郎, 井桁裕文, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S307 - S307 2020.9

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統合失調症罹患状態一致一卵性双生児家系の全エクソーム解析および症例・対照研究

渡部雄一郎, 保谷智史, 布川綾子, 澁谷雅子, 井桁裕文, 森川亮, 染矢俊幸

精神神経学雑誌 ( 2020特別号 ) S306 - S306 2020.9

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SPATA7遺伝子と統合失調症罹患同胞対・はとこ婚両親エクソーム解析からの展開

渡部雄一郎

先進医薬研究振興財団研究成果報告集 2019年度 42 - 43 2020.3

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Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations/diseases genetic effect(和訳中)

池田匡志, 高橋篤, 鎌谷洋一郎, 桃沢幸秀, 齋藤竹生, 近藤健治, 島崎愛夕, 川瀬康平, 作佐部太也, 岩山佳美, 豊田倫子, 和久田智靖, 菊池充, 金原信久, 山森英長, 安田由華, 渡部雄一郎, 保谷智史, アレクシッチブランコ, 久島周, 新井平伊, 高木学, 服部功太郎, 功刀浩, 岡久祐子, 大沼徹, 尾崎紀夫, 染矢俊幸, 橋本亮太, 吉川武男, 久保充明, 岩田仲生

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集 29回・49回 124 - 124 2019.10

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統合失調症罹患同胞対・両親の全エクソームシーケンス

井桁裕文, 渡部雄一郎, 保谷智史, 森川亮, 小泉暢大栄, 染矢俊幸

精神神経学雑誌 ( 2019特別号 ) S441 - S441 2019.6

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統合失調症患者の脳内ゲノムにおけるコピー数変異の評価

坂井美和子, 渡部雄一郎, 染矢俊幸, 荒木一明, 澁谷雅子, 新里和弘, 大島健一, 國井泰人, 矢部博興, 松本純弥, 和田明, 日野瑞城, 橋本健志, 菱本明豊, 北村登, 入谷修司, 白川治, 前田潔, 宮下哲典, 丹羽真一, 高橋均, 柿田明美, 桑野良三, 那波宏之

精神神経学雑誌 ( 2019特別号 ) S603 - S603 2019.6

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統合失調症多発罹患家系において疾患と共分離する変異の検索

布川綾子, 渡部雄一郎, 金子尚史, 村竹辰之, 染矢俊幸

精神神経学雑誌 ( 2019特別号 ) S441 - S441 2019.6

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統合失調症におけるマクロファージ遊走阻止因子(MIF)の血清濃度増加と遺伝子多型関連解析

岡崎賢志, 大塚郁夫, 渡部雄一郎, 朴秀賢, 新名尚史, 平田尚士, 蓬莱政, 染矢俊幸, 曽良一郎, 菱本明豊

精神神経学雑誌 ( 2019特別号 ) S441 - S441 2019.6

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統合失調症患者・両親トリオ20家系の全エクソーム解析

保谷智史, 渡部雄一郎, 澁谷雅子, 井桁裕文, 森川亮, 染矢俊幸

精神神経学雑誌 ( 2019特別号 ) S758 - S758 2019.6

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カルバマゼピン中止後に一過性脳梁膨大部病変が出現した双極性障害の1例

高須庸平, 信田慶太, 菊地佑, 渡部雄一郎, 染矢俊幸

精神神経学雑誌 ( 2019特別号 ) S652 - S652 2019.6

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統合失調症罹患状態一致一卵性双生児家系のエクソーム解析

保谷智史, 渡部雄一郎, 布川綾子, 井桁裕文, 森川亮, 澁谷雅子, 染矢俊幸

精神神経学雑誌 ( 2019特別号 ) S758 - S758 2019.6

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著しい精神運動興奮により措置入院に至った抗NMDA受容体脳炎の1例

湯川尊行, 小澤鉄太郎, 寺島健史, 伊藤岳, 渡部雄一郎, 信田慶太, 菊地佑, 染矢俊幸

精神神経学雑誌 ( 2019特別号 ) S619 - S619 2019.6

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自閉スペクトラム症罹患同胞対3ペアのエクソーム解析

澁谷雅子, 渡部雄一郎, 保谷智史, 森川亮, 江川純, 杉本篤言, 井桁裕文, 林剛丞, 染矢俊幸

精神神経学雑誌 ( 2019特別号 ) S637 - S637 2019.6

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2型糖尿病を合併した治療抵抗性統合失調症にクロザピンを用いた1例

湯川尊行, 小原伸雅, 新藤雅延, 井上絵美子, 有波浩, 恩田啓伍, 渡部雄一郎, 染矢俊幸

精神神経学雑誌 ( 2019特別号 ) S599 - S599 2019.6

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統合失調症患者におけるSETD1A遺伝子のシーケンス

森川亮, 井桁裕文, 渡部雄一郎, 保谷智史, 澁谷雅子, 江川純, 染矢俊幸

精神神経学雑誌 ( 2019特別号 ) S615 - S615 2019.6

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統合失調症患者における脳内コンドロイチン硫酸鎖の変化

湯川尊行, 岩倉百合子, 武井延之, 斎藤摩美, 渡部雄一郎, 豊岡和彦, 五十嵐道弘, 新里和弘, 大島健一, 國井泰人, 矢部博興, 松本純弥, 和田明, 日野瑞城, 入谷修司, 丹羽真一, 竹内亮子, 高橋均, 柿田明美, 染矢俊幸, 那波宏之

精神神経学雑誌 ( 2019特別号 ) S410 - S410 2019.6

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ダウン症候群の急激退行とアルツハイマー型認知症の鑑別を要した一例

松木晴香, 折目直樹, 渡部雄一郎, 森川亮, 須貝拓朗, 染矢俊幸

精神神経学雑誌 ( 2019特別号 ) S413 - S413 2019.6

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FBXO18遺伝子の稀な変異と統合失調症のリスク

布川綾子, 保谷智史, 渡部雄一郎, 井上絵美子, 井桁裕文, 澁谷雅子, 江川純, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 39回・47回 179 - 179 2017.9

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はとこ婚の両親を持つ統合失調症罹患同胞家系のエクソーム解析

井桁裕文, 渡部雄一郎, 布川綾子, 井上絵美子, 保谷智史, 澁谷雅子, 江川純, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 39回・47回 189 - 189 2017.9

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SETD1A遺伝子の稀な変異と統合失調症の発症リスク

渡部雄一郎, 井桁裕文, 保谷智史, 布川綾子, 井上絵美子, 江川純, 澁谷雅子, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 39回・47回 189 - 189 2017.9

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PDCD11遺伝子の稀な変異と統合失調症の発症リスク罹患同胞対家系の全エクソーム解析、ターゲットリシーケンス、および症例・対照研究

保谷智史, 渡部雄一郎, 菱本明豊, 布川綾子, 金子尚史, 村竹辰之, 新名尚史, 大塚郁夫, 奥田修二郎, 井上絵美子, 井桁裕文, 澁谷雅子, 江川純, 折目直樹, 曽良一郎, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 39回・47回 177 - 177 2017.9

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精神運動興奮のため措置入院となった非ヘルペス性辺縁系脳炎の1例

湯川尊行, 小澤鉄太郎, 寺島健史, 伊藤岳, 菊地佑, 信田慶太, 渡部雄一郎

新潟医学会雑誌 131 ( 9 ) 561 - 561 2017.9

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4 カルバマゼピンの中止により一過性脳梁膨大部病変を呈した1例 (Ⅰ.一般演題, 第18回新潟総合病院精神医学研究会)

高須庸平, 信田慶太, 菊地佑, 渡部雄一郎

新潟医学会雑誌 131 ( 3 ) 189 - 189 2017.3

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統合失調症罹患同胞対のエクソーム解析に基づくリスク遺伝子の同定

保谷智史, 渡部雄一郎, 染矢俊幸

新潟県医師会報 ( 803 ) 9 - 10 2017.2

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医学生への精神面の支援の取り組み

澁谷雅子, 伊藤正洋, 渡部雄一郎, 遠藤直人, 佐藤昇, 土田正則, 牛木辰男, 鈴木利哉, 新潟大学医学科学務委員会

医学教育 47 ( Suppl. ) 233 - 233 2016.7

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自閉スペクトラム症多発罹患家系のエクソーム解析を起点としたリスク遺伝子の追究

井上絵美子, 江川純, 渡部雄一郎, 染矢俊幸

新潟県医師会報 ( 790 ) 10 - 11 2016.1

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自閉スペクトラム症多発罹患家系の全エクソームシーケンスおよびフォローアップ研究

井上絵美子, 渡部雄一郎, 江川純, 杉本篤言, 布川綾子, 澁谷雅子, 井桁裕文, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 37回・45回 209 - 209 2015.9

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統合失調症多発罹患家系のエクソーム解析

渡部雄一郎, 江川純, 澁谷雅子, 布川綾子, 金子尚史, 村竹辰之, 井桁裕文, 井上絵美子, 保谷智史, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 37回・45回 192 - 192 2015.9

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自閉スペクトラム症罹患同胞2家系のエクソーム解析および2段階フォローアップ解析

江川純, 渡部雄一郎, 王晨堯, 井上絵美子, 杉本篤言, 杉山登志郎, 井桁裕文, 布川綾子, 澁谷雅子, 久島周, 折目直樹, 林剛丞, 岡田俊, 宇野洋太, 尾崎紀夫, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 37回・45回 209 - 209 2015.9

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統合失調症のニコチン依存におけるCadherin 13の役割 Reviewed

大塚郁夫, Hishimoto Akitoyo, 渡部雄一郎, 朴秀賢, 笠原好之, Ichiro Sora

日本アルコール・薬物医学会雑誌 50 ( 4号 ) 207 - 207 2015.8

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シミュレータを用いた高校生に対する新潟大学医学科体験講座の効果

伊藤正洋, 渡部雄一郎, 赤石隆夫, 鈴木利哉

日本シミュレーション医療教育学会雑誌 3 69 - 69 2015.6

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長野県北部地震（新潟・長野県境地震）被災地における精神健康追跡調査

北村秀明, 渡部雄一郎, 染矢俊幸

新潟大学災害・復興科学研究所年報 3 130 - 131 2014.12

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共用試験の成績と医師国家試験の合否に関する検討

伊藤正洋, 鈴木利哉, 渡部雄一郎, 赤石隆夫, 遠藤直人, 佐藤昇, 牛木辰男

医学教育 45 ( Suppl. ) 140 - 140 2014.7

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新潟大学における聴診法に関するシミュレーション教育の問題点

伊藤正洋, 鈴木利哉, 渡部雄一郎, 赤石隆夫, 高橋姿

日本シミュレーション医療教育学会雑誌 2 73 - 74 2014.6

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ポストGWAS:SLC12A5と統合失調症との関連解析

石黒浩毅, 田畑光一, 田畑光一, 曽我部博文, 中山桜, 稲田俊也, 染谷俊幸, 渡部雄一郎, 氏家寛, 岩田仲生, 尾崎紀夫, 佐々木司, 有波忠雄, 本橋伸高

日本生物学的精神医学会誌 2014

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統合失調症におけるIL-19遺伝子の発現量的形質遺伝子座(eQTL)におけるハプロタイプ解析

岡崎賢志, 渡部雄一郎, 大塚郁夫, 吉田正邦, 白岩恭一, 毛利健太朗, ウォラパット・ラッタアーパー, イルワン・スプリヤント, 江口典臣, 笹田徹, 福武将映, 布川綾子, 染矢俊幸, 白川治, 菱本明豊, 曽良一郎

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集 23回・43回 230 - 230 2013.10

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災害とレジリエンス : 長野県北部地震（新潟・長野県境地震）被災地における精神健康調査から

北村秀明, 渡部雄一郎, 染矢俊幸

新潟大学災害・復興科学研究所年報 2 153 - 154 2013.9

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有用かつ低コストの骨髄穿刺シミュレータ

鈴木利哉, 伊藤正洋, 渡部雄一郎, 赤石隆夫, 増子正義, 古川達雄, 鳥羽健, 奈良信雄

日本シミュレーション医療教育学会雑誌 1 21 - 21 2013.7

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遺伝効果の強い統合失調症リスク変異の探索

渡部雄一郎

上原記念生命科学財団研究報告集 27 1 - 4 2013

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Rare missense variations of TPH2 and risk of autism: Exon resequensing and association analysis

J. Egawa, Y. Watanabe, A. Nunokawa, T. Endo, N. Kaneko, R. Tamura, T. Sugiyama, T. Someya

JOURNAL OF NEUROCHEMISTRY 123 69 - 69 2012.10

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Case-control study and meta-analysis did not confirm an association between DRD2 Ser311Cys and schizophrenia in the Japanese

Y. Watanabe, A. Nunokawa, N. Kaneko, M. Shibuya, J. Egawa, N. Fukui, H. Igeta, T. Someya

JOURNAL OF NEUROCHEMISTRY 123 75 - 75 2012.10

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A case-control study and meta-analysis of association between a common copy number variation of the glutathione S-transferase mu 1(GSTM1) gene and schizophrenia

A. Nunokawa, Y. Watanabe, N. Kaneko, M. Shibuya, H. Igeta, T. Someya

JOURNAL OF NEUROCHEMISTRY 123 75 - 76 2012.10

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長野県北部地震（新潟・長野県境地震）被災地における精神健康調査

北村秀明, 渡部雄一郎, 染矢俊幸

新潟大学災害・復興科学研究所年報 1 135 - 136 2012.10

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精神疾患に関する教育啓発プログラムの開発

渡部雄一郎, 吉井初美, 北村秀明, 赤澤宏平

新潟大学災害・復興科学研究所年報 1 137 - 138 2012.10

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骨髄穿刺シミュレータを用いたクリニカルクラークシップの有用性

鈴木利哉, 伊藤正洋, 渡部雄一郎, 赤石隆夫, 増子正義, 古川達雄, 鳥羽健, 奈良信雄

医学教育 43 ( Suppl. ) 64 - 64 2012.7

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Case-control study and meta-analysis of Ser311Cys polymorphism in the DRD2 gene demonstrate lack of association with risk for schizophrenia in the Japanese population

Y. Watanabe, A. Nunokawa, N. Kaneko, M. Shibuya, J. Egawa, N. Fukui, T. Someya

GENETICS AND MOLECULAR RESEARCH 11 ( 2 ) 1142 - 1145 2012

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DOI： 10.4238/2012.April.27.13

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SLC1A1遺伝子多型と統合失調症との関連解析

飯田周平, 堀内泰江, 飯嶋良味, 石黒浩毅, 稲田俊也, 渡部雄一郎, 染矢俊幸, 氏家寛, 岩田仲生, 尾崎紀夫, 功刀浩, 栃木衛, 糸川昌成, 糸川昌成, 新井誠, 新里和弘, 入谷修司, 柿田明美, 高橋均, 那波宏之, 有波忠雄

日本人類遺伝学会大会プログラム・抄録集 56th 173 2011

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退院後1年間における統合失調症患者の抗精神病薬に対するアドヒアランス

根本麻知子, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 124 ( 9 ) 522 - 522 2010.9

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ミオシン重鎖9遺伝子と統合失調症の関連大規模確認解析

渡部雄一郎, 布川綾子, 金子尚史, 染矢俊幸

新潟県医師会報 ( 715 ) 8 - 9 2009.10

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MYH9遺伝子と統合失調症との関連解析(A case-control association study of the MYH9 gene with schizophrenia)

渡部雄一郎, 布川綾子, 金子尚史, 染矢俊幸

神経化学 48 ( 2-3 ) 223 - 223 2009.6

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Japanese Adult Reading Testの限界漢字熟語音読の世代・文化的特徴について

根本麻知子, 渡部雄一郎, 布川綾子, 染矢俊幸

新潟医学会雑誌 123 ( 3 ) 149 - 150 2009.3

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統合失調症におけるドパミンD3受容体遺伝子の包括的遺伝解析

布川綾子, 渡部雄一郎, 金子尚史, 染矢俊幸

新潟県医師会報 ( 706 ) 7 - 8 2009.1

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二段階サンプルによる関節リウマチ感受性遺伝子と統合失調症との関連研究

金子尚史, 渡部雄一郎, 布川綾子, 村竹辰之, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 糸川昌成, 音羽健司, 尾崎紀夫, 染矢俊幸

日本生物学的精神医学会プログラム・講演抄録 31st 2009

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アルツハイマー型認知症との鑑別に123I-MIBG心筋シンチグラフィが有用であったレビー小体型認知症の1例

常山暢人, 渡部雄一郎, 澤村一司, 染矢俊幸

新潟医学会雑誌 122 ( 11 ) 648 - 649 2008.11

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双極II型障害として治療されていたクッシング症候群による気分障害の1例

杉本篤言, 澤村一司, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 122 ( 11 ) 651 - 651 2008.11

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高圧酸素療法により高次機能障害の改善がみられた一酸化炭素中毒間欠型の1例

清野うらら, 小泉暢大栄, 寺島健史, 三浦まゆみ, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 122 ( 11 ) 650 - 651 2008.11

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染色体22q領域におけるマイクロサテライトマーカーによる統合失調症脆弱性座位の探索

天金秀樹, 渡部雄一郎, 村竹辰之, 金子尚史, 布川綾子, 染矢俊幸

新潟医学会雑誌 122 ( 7 ) 397 - 398 2008.7

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新潟における簡易精神鑑定の現状

杉本篤言, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 122 ( 7 ) 398 - 399 2008.7

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Quetiapineからaripiprazoleへの切り替えにより錐体外路症状が悪化したパーキンソン病の1例

小泉暢大栄, 渡部雄一郎, 湯川尊行, 染矢俊幸

新潟医学会雑誌 122 ( 7 ) 396 - 397 2008.7

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大学病院精神科にコンサルトされた大うつ病性障害患者の特徴

井上絵美子, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 122 ( 6 ) 355 - 356 2008.6

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Olanzapineからaripiprazoleへの置換によりメタボリックシンドロームが改善した統合失調症の1例

湯川尊行, 渡部雄一郎, 小泉暢大栄, 福井直樹, 鈴木雄太郎, 染矢俊幸

新潟医学会雑誌 122 ( 6 ) 354 - 355 2008.6

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Paroxetineとnortriptylineとの薬物相互作用により錐体外路症状がみられた1例

横山裕一, 渡部雄一郎, 須貝拓朗, 福井直樹, 高橋誠, 染矢俊幸

新潟医学会雑誌 121 ( 10 ) 589 - 589 2007.10

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サイトカイン・神経栄養因子の遺伝子多型と統合失調症との関連研究

布川綾子, 渡部雄一郎, 村竹辰之, 福井直樹, 金子尚史, 小泉暢大栄, 染矢俊幸

新潟医学会雑誌 121 ( 10 ) 590 - 591 2007.10

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Wernicke脳症を疑われMRIが診断に有用であったMarchiafave-Bignami病の1例

小泉暢大栄, 渡部雄一郎, 石川和宏, 鈴木雄太郎, 佐藤正久, 染矢俊幸

新潟医学会雑誌 121 ( 10 ) 591 - 592 2007.10

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関節リウマチ感受性遺伝子と統合失調症との関連研究

布川綾子, 渡部雄一郎, 村竹辰之, 金子尚史, 福井直樹, 奈良康, 染矢俊幸

新潟医学会雑誌 121 ( 6 ) 361 - 361 2007.6

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NRG1と統合失調症の大規模サンプルを用いた遺伝子関連解析

池田匡志, 高橋長秀, 齋藤真一, BRANKO Aleksic, 渡部雄一郎, 布川綾子, 山之内芳雄, 北島剛司, 木下葉子, 岸太郎, 川島邦裕, 橋本亮太, 氏家寛, 稲田俊也, 染矢俊幸, 尾崎紀夫, 岩田仲生

日本生物学的精神医学会プログラム・講演抄録 29th 2007

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神経精神症状に対してミルナシプランの単剤投与が奏効した進行性核上性麻痺の1例

横山裕一, 渡部雄一郎, 小澤鉄太郎, 今村徹, 福井直樹, 高橋誠, 染矢俊幸

新潟医学会雑誌 120 ( 10 ) 599 - 600 2006.10

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無床総合病院精神科におけるコンサルテーション・リエゾン活動非常勤医としての経験から

渡部雄一郎, 染矢俊幸

新潟医学会雑誌 120 ( 10 ) 598 - 598 2006.10

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腫瘍壊死因子(TNF-α)遺伝子のプロモーター多型と統合失調症との関連研究

布川綾子, 渡部雄一郎, 村竹辰之, 金子尚史, 福井直樹, 奈良康, 染矢俊幸

神経化学 45 ( 2-3 ) 363 - 363 2006.8

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ErbB3遺伝子と統合失調症の関連研究

福井直樹, 渡部雄一郎, 村竹辰之, 金子尚史, 布川綾子, 北村秀明, 染矢俊幸

神経化学 45 ( 2-3 ) 370 - 370 2006.8

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新生仔期PCP投与による皮質辺縁系BDNFの増加とPPI異常

高橋誠, 渡部雄一郎, 水野誠, 鍋島俊隆, 染矢俊幸, 那波宏之

神経化学 45 ( 2-3 ) 466 - 466 2006.8

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Risperidone投与中に水中毒から悪性症候群と横紋筋融解症を呈した統合失調症の1例

渡部雄一郎, 小林慎一, 熊谷敬一, 山本佳子, 田中敏春, 藤島直人, 内藤明彦, 染矢俊幸

新潟医学会雑誌 120 ( 2 ) 122 - 123 2006.2

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サイトカイン・神経栄養因子の遺伝子多型と統合失調症との関連研究

渡部雄一郎, 福井直樹, 金子尚史, 村竹辰之, 染矢俊幸

新潟医学会雑誌 119 ( 11 ) 696 - 697 2005.11

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慢性期統合失調症患者に対する抗精神病薬減量化の試み

渡部雄一郎, 川室優, 染矢俊幸

新潟医学会雑誌 119 ( 10 ) 638 - 638 2005.10

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統合失調症の分子病態 EGFとIL-1はドーパミン性ニューロンに対し神経栄養活性を示すが後に認識異常を起こす(Neurotrophic activity of EGF and IL-1 on dopaminergic neurons and later cognitive abnormalities)

那波宏之, 岩倉百合子, 水野誠, 津田法子, 鄭英君, 渡部雄一郎, 染矢俊幸

神経化学 44 ( 2-3 ) 172 - 172 2005.8

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【統合失調症】治療薬開発の現状と見通し

渡部雄一郎, 染矢俊幸

こころの科学 ( 120 ) 36 - 41 2005.3

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白血病阻害因子の脳内投与によるドパミン・シグナルおよび潜在制止の異常(Central Administration of Leukemia Inhibitory Factor Disrupts Dopaminergic Signaling and Latent Inhibition)

渡部雄一郎, 武井延之, 柿田明美, 染矢俊幸, 那波宏之

神経化学 43 ( 2-3 ) 490 - 490 2004.8

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白血病阻害因子のラット脳内投与による認知・行動変化

渡部雄一郎, 橋本慎也, 水野誠, 那波宏之, 染矢俊幸

新潟医学会雑誌 118 ( 7 ) 375 - 376 2004.7

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Other Link： http://search.jamas.or.jp/link/ui/2005011342
Zung自己記入式抑うつ評価尺度及び不安評価尺度の臨床的意義について

渡部雄一郎, 坂井美和子, 塩入俊樹, 細木俊宏, 染矢俊幸

新潟医学会雑誌 115 ( 6 ) 280 - 281 2001.6

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9）精神分裂病患者出生の季節変動 : 予備的研究（平成10年度新潟大学医学部精神医学教室同窓会集談会）

渡部雄一郎, 村竹辰之, 金子尚史, 鈴木保穂, 和泉貞次, 内藤明彦, 桑原秀樹, 馬場正彦

新潟医学会雑誌 113 ( 2 ) 129 - 130 1999.2

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Other Link： http://search.jamas.or.jp/link/ui/2000038071

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Presentations

統合失調症罹患同胞対・両親の全エクソームシーケンス

井桁裕文, 渡部雄一郎, 保谷智史, 森川亮, 小泉暢大栄, 小泉暢大栄, 染矢俊幸

日本精神神経学会総会プログラム・抄録集 2019

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統合失調症患者・両親トリオ20家系の全エクソーム解析

保谷智史, 渡部雄一郎, 澁谷雅子, 井桁裕文, 森川亮, 染矢俊幸

日本精神神経学会総会プログラム・抄録集 2019

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統合失調症患者におけるSETD1A遺伝子のシーケンス

森川亮, 井桁裕文, 渡部雄一郎, 保谷智史, 澁谷雅子, 江川純, 染矢俊幸

日本精神神経学会総会プログラム・抄録集 2019

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統合失調症多発罹患家系において疾患と共分離する変異の検索

布川綾子, 布川綾子, 渡部雄一郎, 金子尚史, 村竹辰之, 染矢俊幸

日本精神神経学会総会プログラム・抄録集 2019

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統合失調症患者の脳内ゲノムにおけるコピー数変異の評価

坂井美和子, 坂井美和子, 渡部雄一郎, 染矢俊幸, 荒木一明, 澁谷雅子, 新里和弘, 大島健一, 國井泰人, 矢部博興, 松本純弥, 和田明, 日野瑞城, 橋本健志, 菱本明豊, 北村登, 入谷修司, 入谷修司, 白川治, 白川治, 前田潔, 前田潔, 宮下哲典, 丹羽真一, 高橋均, 柿田明美, 桑野良三, 那波宏之

日本精神神経学会総会プログラム・抄録集 2019

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自閉スペクトラム症罹患同胞対3ペアのエクソーム解析

澁谷雅子, 渡部雄一郎, 保谷智史, 森川亮, 江川純, 杉本篤言, 井桁裕文, 林剛丞, 染矢俊幸

日本精神神経学会総会プログラム・抄録集 2019

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著しい精神運動興奮により措置入院に至った抗NMDA受容体脳炎の1例

湯川尊行, 小澤鉄太郎, 寺島健史, 伊藤岳, 伊藤岳, 渡部雄一郎, 渡部雄一郎, 信田慶太, 信田慶太, 菊地佑, 菊地佑, 染矢俊幸

日本精神神経学会総会プログラム・抄録集 2019

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統合失調症患者における脳内コンドロイチン硫酸鎖の変化

湯川尊行, 湯川尊行, 湯川尊行, 岩倉百合子, 武井延之, 斎藤摩美, 斎藤摩美, 渡部雄一郎, 豊岡和彦, 五十嵐道弘, 五十嵐道弘, 新里和弘, 大島健一, 國井泰人, 矢部博興, 松本純弥, 和田明, 日野瑞城, 入谷修司, 入谷修司, 丹羽真一, 竹内亮子, 高橋均, 柿田明美, 染矢俊幸, 那波宏之

日本精神神経学会総会プログラム・抄録集 2019

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統合失調症罹患状態一致一卵性双生児家系のエクソーム解析

保谷智史, 渡部雄一郎, 布川綾子, 布川綾子, 井桁裕文, 森川亮, 澁谷雅子, 染矢俊幸

日本精神神経学会総会プログラム・抄録集 2019

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カルバマゼピン中止後に一過性脳梁膨大部病変が出現した双極性障害の1例

高須庸平, 信田慶太, 菊地佑, 渡部雄一郎, 染矢俊幸

日本精神神経学会総会プログラム・抄録集 2019

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ダウン症候群の急激退行とアルツハイマー型認知症の鑑別を要した一例

松木晴香, 折目直樹, 渡部雄一郎, 森川亮, 須貝拓朗, 染矢俊幸

日本精神神経学会総会プログラム・抄録集 2019

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統合失調症におけるマクロファージ遊走阻止因子(MIF)の血清濃度増加と遺伝子多型関連解析

岡崎賢志, 大塚郁夫, 渡部雄一郎, 朴秀賢, 新名尚史, 平田尚士, 蓬莱政, 染矢俊幸, 曽良一郎, 菱本明豊

日本精神神経学会総会プログラム・抄録集 2019

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2型糖尿病を合併した治療抵抗性統合失調症にクロザピンを用いた1例

湯川尊行, 小原伸雅, 新藤雅延, 新藤雅延, 井上絵美子, 有波浩, 有波浩, 恩田啓伍, 渡部雄一郎, 渡部雄一郎, 染矢俊幸

日本精神神経学会総会プログラム・抄録集 2019

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SPATA7遺伝子の複合ヘテロ接合体変異と統合失調症の発症リスク:罹患同胞対と両親の全エクソームシーケンスおよび症例・対照研究

井桁裕文, 渡部雄一郎, 保谷智史, 森川亮, 小泉暢大栄, 小泉暢大栄, 染矢俊幸

日本生物学的精神医学会(Web) 2019

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統合失調症発症に大きな影響力をもつde novo変異の探索:患者・両親トリオ24家系の全エクソーム解析

保谷智史, 渡部雄一郎, 澁谷雅子, 井桁裕文, 森川亮, 染矢俊幸

日本生物学的精神医学会(Web) 2019

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PDCD11遺伝子の稀な変異と統合失調症の発症リスク罹患同胞対家系の全エクソーム解析、ターゲットリシーケンス、および症例・対照研究

保谷智史, 渡部雄一郎, 菱本明豊, 布川綾子, 金子尚史, 村竹辰之, 新名尚史, 大塚郁夫, 奥田修二郎, 井上絵美子, 井桁裕文, 澁谷雅子, 江川純, 折目直樹, 曽良一郎, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2017.9

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FBXO18遺伝子の稀な変異と統合失調症のリスク

布川綾子, 保谷智史, 渡部雄一郎, 井上絵美子, 井桁裕文, 澁谷雅子, 江川純, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2017.9

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はとこ婚の両親を持つ統合失調症罹患同胞家系のエクソーム解析

井桁裕文, 渡部雄一郎, 布川綾子, 井上絵美子, 保谷智史, 澁谷雅子, 江川純, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2017.9

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SETD1A遺伝子の稀な変異と統合失調症の発症リスク

渡部雄一郎, 井桁裕文, 保谷智史, 布川綾子, 井上絵美子, 江川純, 澁谷雅子, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2017.9

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4 精神運動興奮のため措置入院となった非へルペス性辺縁系脳炎の1例 (Ⅰ.一般演題, 第19回新潟GHP研究会)

湯川尊行, 小澤鉄太郎, 寺島健史, 伊藤岳, 菊地佑, 信田慶太, 渡部雄一郎

新潟医学会雑誌 2017.9

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4 カルバマゼピンの中止により一過性脳梁膨大部病変を呈した1例 (Ⅰ.一般演題, 第18回新潟総合病院精神医学研究会)

高須庸平, 信田慶太, 菊地佑, 渡部雄一郎

新潟医学会雑誌 2017.3

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医学生への精神面の支援の取り組み

澁谷雅子, 伊藤正洋, 渡部雄一郎, 遠藤直人, 佐藤昇, 土田正則, 牛木辰男, 鈴木利哉, 新潟大学医学科学務委員会

医学教育 2016.7

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UNC13B遺伝子の稀な変異と統合失調症の発症リスク

渡部雄一郎, 江川純, 保谷智史, 布川綾子, 澁谷雅子, 池田匡志, 井上絵美子, 奥田修二郎, 近藤健治, 齊藤竹生, 金子尚史, 村竹辰之, 井桁裕文, 岩田仲生, 染矢俊幸

日本生物学的精神医学会(Web) 2016

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統合失調症の高解像度ゲノムコピー数変異解析

久島周, 久島周, アレクシッチブランコ, 中杤昌弘, 島村徹平, 椎野智子, 吉見陽, 木村大樹, 高崎悠登, WANG Chenyao, XING Jingrui, 石塚佳奈子, 大矢友子, 岡田俊, 山本敏充, 新井誠, 糸川昌成, CHEN Chia‐Hsiang, 鈴木道雄, 高橋努, 橋本亮太, 渡部雄一郎, 染矢俊幸, 池田匡志, 岩田仲生, 吉川武男, 沼田周助, 大森哲郎, 國本正子, 森大輔, 尾崎紀夫

日本生物学的精神医学会(Web) 2016

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自閉スペクトラム症におけるCLN8遺伝子のリシークエンスおよび関連解析

井上絵美子, 渡部雄一郎, XING Jingrui, 久島周, 江川純, 奥田修二郎, 保谷智史, 岡田俊, 宇野洋太, 石塚佳奈子, 杉本篤言, 井桁裕文, 布川綾子, 布川綾子, 杉山登志郎, 尾崎紀夫, 染矢俊幸

日本生物学的精神医学会(Web) 2016

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東アジア人におけるGSTM1遺伝子のコピー数多型と統合失調症との関連に関するメタ解析

井桁裕文, 渡部雄一郎, 保谷智史, 染矢俊幸

日本生物学的精神医学会(Web) 2016

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PDCD11遺伝子の稀な変異と統合失調症の発症リスク:罹患同胞対・両親3家系の全エクソーム解析

保谷智史, 渡部雄一郎, 布川綾子, 布川綾子, 金子尚史, 金子尚史, 村竹辰之, 村竹辰之, 井上絵美子, 澁谷雅子, 井桁裕文, 江川純, 染矢俊幸

日本生物学的精神医学会(Web) 2016

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自閉スペクトラム症罹患一卵性双生児を含む家系におけるエクソームシークエンスおよびフォローアップ解析

江川純, 渡部雄一郎, 杉本篤言, 布川綾子, 澁谷雅子, 井桁裕文, 井上絵美子, 保谷智史, 折目直樹, 林剛丞, 杉山登志郎, 染矢俊幸

日本生物学的精神医学会(Web) 2016

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統合失調症罹患同胞対・両親3家系のエクソーム解析および3段階関連解析

布川綾子, 布川綾子, 渡部雄一郎, 澁谷雅子, 池田匡志, 菱本明豊, 近藤健治, 江川純, 金子尚史, 金子尚史, 村竹辰之, 村竹辰之, 齊藤竹生, 岡崎賢志, 島崎愛夕, 井桁裕文, 井上絵美子, 保谷智史, 須貝拓朗, 曽良一郎, 岩田仲生, 染矢俊幸

日本生物学的精神医学会(Web) 2016

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統合失調症多発罹患家系のエクソーム解析

渡部雄一郎, 江川純, 澁谷雅子, 布川綾子, 金子尚史, 村竹辰之, 井桁裕文, 井上絵美子, 保谷智史, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2015.9

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自閉スペクトラム症多発罹患家系の全エクソームシーケンスおよびフォローアップ研究

井上絵美子, 渡部雄一郎, 江川純, 杉本篤言, 布川綾子, 澁谷雅子, 井桁裕文, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2015.9

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東アジア人におけるCMYA5遺伝子と統合失調症との関連に関するメタアナリシス

保谷智史, 澁谷雅子, 渡部雄一郎, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2015.9

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自閉スペクトラム症罹患同胞2家系のエクソーム解析および2段階フォローアップ解析

江川純, 渡部雄一郎, 王晨堯, 井上絵美子, 杉本篤言, 杉山登志郎, 井桁裕文, 布川綾子, 澁谷雅子, 久島周, 折目直樹, 林剛丞, 岡田俊, 宇野洋太, 尾崎紀夫, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2015.9

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BDNF遺伝子C270T多型と統合失調症との関連最新のメタ解析

布川綾子, 渡部雄一郎, 染矢俊幸

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2015.9

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統合失調症におけるCadherin13遺伝子多型解析(Association analysis of the Cadherin 13 gene with schizophrenia in the Japanese population)

大塚郁夫, 渡部雄一郎, 菱本明豊, 朴秀賢, 毛利健太朗, 白岩恭一, 岡崎賢志, 布川綾子, 白川治, 染矢俊幸, 曽良一郎

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2015.9

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統合失調症のニコチン依存におけるCadherin 13の役割

大塚郁夫, 菱本明豊, 渡部雄一郎, 朴秀賢, 笠原好之, 曽良一郎

日本アルコール・薬物医学会雑誌 2015.8

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シミュレータを用いた高校生に対する新潟大学医学科体験講座の効果

伊藤正洋, 渡部雄一郎, 赤石隆夫, 鈴木利哉

日本シミュレーション医療教育学会雑誌 2015.6

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The effects of campus visits including simulation-based learning on high school students

伊藤正洋, 鈴木利哉, 渡部雄一郎

日本シミュレーション医療教育学会雑誌 = Journal of Japan Association for Simulation-based Education in Healthcare Professionals 2015.6

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新潟大学医学部医学科(本学科)では、医学への興味を高め、本学科への進学希望者を増加させることを目的として、シミュレータ体験を中心とした体験講座を開催している。その効果を検討するため、2012-2013年度に体験講座に参加した高校生87人、ならびに2014年度の本学科入学者123人に対して、アンケート調査を実施し、解析した。高校生に対するシミュレータ実習を含む体験講座の評価は良く、参加者の医療関係職を希望する気持ちの強さは有意に増加した(P<0.001)。2014年度本学科入学者のうち69人(56%)は、全国の医学科で開催されている体験講座に参加した経験があり、そのなかで本学科の体験講座に参加した34人中28人の学生は、医学科進学を考える上で影響を受けたと回答した。(著者抄録)

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共用試験の成績と医師国家試験の合否に関する検討

伊藤正洋, 鈴木利哉, 渡部雄一郎, 赤石隆夫, 遠藤直人, 佐藤昇, 牛木辰男

医学教育 2014.7

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新潟大学における聴診法に関するシミュレーション教育の問題点

伊藤正洋, 鈴木利哉, 渡部雄一郎, 赤石隆夫, 高橋姿

日本シミュレーション医療教育学会雑誌 2014.6

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マイクロRNA30E遺伝子の稀な変異と統合失調症との関連

江川純, 飯島良味, 渡部雄一郎, 布川綾子, 金子尚史, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 糸川昌成, 佐々木司, 尾崎紀夫, 橋本亮太, 澁谷雅子, 井桁裕文, 染矢俊幸

日本生物学的精神医学会誌 2014

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マイクロRNA137遺伝子のリシーケンスおよび統合失調症との関連解析

井上絵美子, 江川純, 布川綾子, 澁谷雅子, 渡部雄一郎, 金子尚史, 井桁裕文, 染矢俊幸

日本生物学的精神医学会誌 2014

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TPH2遺伝子と日本人統合失調症との2段階関連解析

布川綾子, 渡部雄一郎, 飯嶋良味, 江川純, 金子尚史, 澁谷雅子, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 栃木衛, 功刀浩, 糸川昌成, 尾崎紀夫, 橋本亮太, 染矢俊幸

日本生物学的精神医学会誌 2014

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ポストGWAS:SLC12A5と統合失調症との関連解析

石黒浩毅, 田畑光一, 曽我部博文, 中山桜, 稲田俊也, 染谷俊幸, 渡部雄一郎, 氏家寛, 岩田仲生, 尾崎紀夫, 佐々木司, 有波忠雄, 本橋伸高

日本生物学的精神医学会誌 2014

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マイクロRNA138‐2遺伝子の稀な変異と統合失調症との関連

渡部雄一郎, 菱本明豊, 澁谷雅子, 布川綾子, 金子尚史, 井桁裕文, 江川純, 毛利健太朗, 曽良一郎, 染矢俊幸

日本生物学的精神医学会誌 2014

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インターロイキン1ベータ遺伝子と統合失調症との関連研究

澁谷雅子, 渡部雄一郎, 布川綾子, 江川純, 金子尚史, 井桁裕文, 染矢俊幸

日本生物学的精神医学会誌 2014

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統合失調症におけるIL-19遺伝子の発現量的形質遺伝子座(eQTL)におけるハプロタイプ解析

岡崎賢志, 渡部雄一郎, 大塚郁夫, 吉田正邦, 白岩恭一, 毛利健太朗, ウォラパット・ラッタアーパー, イルワン・スプリヤント, 江口典臣, 笹田徹, 福武将映, 布川綾子, 染矢俊幸, 白川治, 菱本明豊, 曽良一郎

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集 2013.10

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有用かつ低コストの骨髄穿刺シミュレータ

鈴木利哉, 伊藤正洋, 渡部雄一郎, 赤石隆夫, 増子正義, 古川達雄, 鳥羽健, 奈良信雄

日本シミュレーション医療教育学会雑誌 2013.7

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オキシトシン受容体遺伝子と統合失調症の関連解析

井桁裕文, 渡部雄一郎, 金子尚史, 布川綾子, 澁谷雅子, 江川純, 染矢俊幸

日本生物学的精神医学会誌 2012.9

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骨髄穿刺シミュレータを用いたクリニカルクラークシップの有用性

鈴木利哉, 伊藤正洋, 渡部雄一郎, 赤石隆夫, 増子正義, 古川達雄, 鳥羽健, 奈良信雄

医学教育 2012.7

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健康診断予約システム導入の効果について

黒田毅, 神主京子, 佐藤千代子, 上ノ山友子, 渡部雄一郎, 真島一郎, 村山賢一, 七里佳代, 鈴木芳樹

CAMPUS HEALTH 2012.2

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新潟大学におけるキャンパス内全面禁煙に向けた保健管理センターの取組み

佐藤千代子, 神主京子, 上ノ山友子, 渡部雄一郎, 真島一郎, 村山賢一, 七里佳代, 黒田毅, 鈴木芳樹

CAMPUS HEALTH 2012.2

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新潟大学の医療系学生における結核対策について

真島一郎, 佐藤千代子, 神主京子, 上ノ山友子, 渡部雄一郎, 村山賢一, 七里佳代, 黒田毅, 鈴木芳樹

CAMPUS HEALTH 2012.2

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平成生まれの大学生は未熟化しているのか?

七里佳代, 渡部雄一郎, 村山賢一, 佐藤千代子, 神主京子, 上ノ山友子, 真島一郎, 黒田毅, 鈴木芳樹

CAMPUS HEALTH 2012.2

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新潟大学の医療系学生における結核対策について

真島一郎, 佐藤千代子, 神主京子, 上ノ山友子, 渡部雄一郎, 村山賢一, 七里佳代, 黒田毅, 鈴木芳樹

Campus Health 2011.10

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大学生における統合失調症発症危険状態スクリーニングに関する予備的研究

渡部雄一郎, 七里佳代, 村山賢一, 真島一郎, 黒田毅, 佐藤千代子, 神主京子, 上ノ山友子, 鈴木芳樹

CAMPUS HEALTH 2011.2

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平成21年度に新潟大学で発生したインフルエンザの特徴

真島一郎, 渡部雄一郎, 村山賢一, 七里佳代, 黒田毅, 神主京子, 佐藤千代子, 上ノ山友子, 鈴木芳樹

CAMPUS HEALTH 2011.2

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学生健診における自動化システム導入の成果と課題

神主京子, 佐藤千代子, 上ノ山友子, 渡部雄一郎, 真島一郎, 村山賢一, 七里佳代, 黒田毅, 鈴木芳樹

CAMPUS HEALTH 2011.2

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SLC1A1遺伝子多型と統合失調症との関連解析

飯田周平, 堀内泰江, 飯嶋良味, 石黒浩毅, 稲田俊也, 渡部雄一郎, 染矢俊幸, 氏家寛, 岩田仲生, 尾崎紀夫, 功刀浩, 栃木衛, 糸川昌成, 新井誠, 新里和弘, 入谷修司, 柿田明美, 高橋均, 那波宏之, 有波忠雄

日本人類遺伝学会大会プログラム・抄録集 2011

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トリプトファン水酸化酵素2(TPH2)遺伝子と広汎性発達障害との関連解析

江川純, 渡部雄一郎, 布川綾子, 金子尚史, 遠藤太郎, 田村立, 増澤菜生, 杉山登志郎, 染矢俊幸

日本生物学的精神医学会誌 2010.10

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ドパミンD3受容体遺伝子と統合失調症のリスク

布川綾子, 渡部雄一郎, 金子尚史, 須貝拓朗, 矢崎沙織, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 佐々木司, 糸川昌成, 尾崎紀夫, 橋本亮太, 染矢俊幸

日本生物学的精神医学会誌 2010.10

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統合失調症多発罹患家系における全ゲノムコピー数多型検索

金子尚史, 渡部雄一郎, 村竹辰之, 布川綾子, 染矢俊幸

日本生物学的精神医学会誌 2010.10

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ミオシン重鎖9遺伝子は統合失調症と関連しない

渡部雄一郎, 天金秀樹, 金子尚史, 布川綾子, 村竹辰之, 石黒浩毅, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 佐々木司, 橋本亮太, 糸川昌成, 尾崎紀夫, 染矢俊幸

日本生物学的精神医学会誌 2010.10

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5 退院後1年間における統合失調症患者の抗精神病薬に対するアドヒアランス(I.一般演題,平成21年度新潟精神医学会)

根本麻知子, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 2010.9

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新入生の麻しんの実態について

真島一郎, 渡部雄一郎, 村山賢一, 七里佳代, 青木定夫, 神主京子, 上ノ山友子, 野口愛子, 鈴木芳樹, 齋藤郁夫, 長尾啓一, 下條文武

CAMPUS HEALTH 2010.2

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大学における職場復帰支援の現状と問題点

村山賢一, 渡部雄一郎, 七里佳代, 真島一郎, 青木定夫, 神主京子, 上ノ山友子, 野口愛子, 鈴木芳樹

CAMPUS HEALTH 2010.2

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新潟大学における学校感染症への対策について

野口愛子, 神主京子, 上ノ山友子, 渡部雄一郎, 真島一郎, 村山賢一, 七里佳代, 青木定夫, 鈴木芳樹

CAMPUS HEALTH 2010.2

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抗精神病薬治療下主観的ウェルビーイング評価尺度短縮版日本語版の心理測定学的特性に関する予備的研究

布川綾子, 渡部雄一郎, 染矢俊幸

日本精神科診断学会プログラム・抄録集 2010

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MYH9遺伝子と統合失調症との関連解析(A case-control association study of the MYH9 gene with schizophrenia)

渡部雄一郎, 布川綾子, 金子尚史, 染矢俊幸

神経化学 2009.6

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1 Japanese Adult Reading Testの限界 : 漢字熟語音読の世代・文化的特徴について(一般演題,平成20年度新潟精神医学会)

根本麻知子, 渡部雄一郎, 布川綾子, 染矢俊幸

新潟医学会雑誌 2009.3

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二段階サンプルによる関節リウマチ感受性遺伝子と統合失調症との関連研究

金子尚史, 渡部雄一郎, 布川綾子, 村竹辰之, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 糸川昌成, 音羽健司, 尾崎紀夫, 染矢俊幸

日本生物学的精神医学会プログラム・講演抄録 2009

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ペプチジルアルギニンデイミナーゼ2(PADI2)遺伝子と統合失調症との関連

渡部雄一郎, 布川綾子, 金子尚史, 染矢俊幸

日本生物学的精神医学会プログラム・講演抄録 2009

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ドネペジルによりパーキンソニズムが悪化したレビー小体型認知症の1例

渡部雄一郎, 常山暢人, 澤村一司, 染矢俊幸

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集 2009

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二酸化炭素吸入試験により誘発されるパニック症状に影響を及ぼす要因の探索:健常者における検討

阿部亮, 渡部雄一郎, 布川綾子, 染矢俊幸

日本精神科診断学会プログラム・抄録集 2009

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Dymeclin遺伝子と統合失調症との関連解析

矢崎沙織, 古賀農人, 石黒浩毅, 糸川昌成, 染矢俊幸, 渡部雄一郎, 稲田俊也, 岩田仲生, 尾崎紀夫, 氏家寛, 功刀浩, 佐々木司, 那波宏之, 高橋均, 柿田明美, 有波忠雄

日本人類遺伝学会大会プログラム・抄録集 2009

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ドパミンD3受容体遺伝子と統合失調症および前頭葉機能との関連

布川綾子, 渡部雄一郎, 金子尚史, 須貝拓朗, 染矢俊幸

日本生物学的精神医学会プログラム・講演抄録 2009

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3 アルツハイマー型認知症との鑑別に^<123>I-MIBG心筋シンチグラフィが有用であったレビー小体型認知症の1例(I.一般演題,第10回新潟GHP研究会)

常山暢入, 渡部雄一郎, 澤村一司, 染矢俊幸

新潟医学会雑誌 2008.11

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6 高圧酸素療法により高次機能障害の改善がみられた一酸化炭素中毒間欠型の1例(I.一般演題,第10回新潟GHP研究会)

清野うらら, 小泉暢大栄, 寺島健史, 三浦まゆみ, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 2008.11

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7 双極II型障害として治療されていたクッシング症候群による気分障害の1例(I.一般演題,第10回新潟GHP研究会)

杉本篤言, 澤村一司, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 2008.11

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4 Quetiapineからaripiprazoleへの切り替えにより錐体外路症状が悪化したパーキンソン病の1例(I.一般演題,平成19年度新潟精神医学会)

小泉暢大栄, 渡部雄一郎, 湯川尊行, 染矢俊幸

新潟医学会雑誌 2008.7

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6 新潟における簡易精神鑑定の現状(I.一般演題,平成19年度新潟精神医学会)

杉本篤言, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 2008.7

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5 染色体22q領域におけるマイクロサテライトマーカーによる統合失調症脆弱性座位の探索(I.一般演題,平成19年度新潟精神医学会)

天金秀樹, 渡部雄一郎, 村竹辰之, 金子尚史, 布川綾子, 染矢俊幸

新潟医学会雑誌 2008.7

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2 Olanzapineからaripiprazoleへの置換によりメタボリックシンドロームが改善した統合失調症の1例(I.一般演題,第9回新潟GHP研究会)

湯川尊行, 渡部雄一郎, 小泉暢大栄, 福井直樹, 鈴木雄太郎, 染矢俊幸

新潟医学会雑誌 2008.6

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4 大学病院精神科にコンサルトされた大うつ病性障害患者の特徴(I.一般演題,第9回新潟GHP研究会)

井上絵美子, 渡部雄一郎, 染矢俊幸

新潟医学会雑誌 2008.6

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グルタミン酸トランスポーター遺伝子(SLC1A1)遺伝子と統合失調症の関連解析

堀内泰江, 古賀農人, 石黒浩毅, 石神千里, 石神千里, 三浦卓, 新里和弘, 入谷修二, 新井誠, 糸川昌成, 高橋誠, 渡部雄一郎, 染谷俊幸, 柿田明美, 高橋均, 那波宏之, 岩田仲生, 氏家寛, 稲田俊也, 尾崎紀夫, 有波忠雄

日本人類遺伝学会大会プログラム・抄録集 2008

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3 サイトカイン・神経栄養因子の遺伝子多型と統合失調症との関連研究(I.一般演題,平成18年度新潟精神医学会)

布川綾子, 渡部雄一郎, 村竹辰之, 福井直樹, 金子尚史, 小泉暢大栄, 染矢俊幸

新潟医学会雑誌 2007.10

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1 Paroxetineとnortriptylineとの薬物相互作用により錐体外路症状がみられた1例(I.一般演題,平成18年度新潟精神医学会)

横山裕一, 渡部雄一郎, 須貝拓朗, 福井直樹, 高橋誠, 染矢俊幸

新潟医学会雑誌 2007.10

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4 Wernicke脳症を疑われMRIが診断に有用であったMarchiafave-Bignami病の1例(I.一般演題,平成18年度新潟精神医学会)

小泉暢大栄, 渡部雄一郎, 石川和宏, 鈴木雄太郎, 佐藤正久, 染矢俊幸

新潟医学会雑誌 2007.10

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4 関節リウマチ感受性遺伝子と統合失調症との関連研究(第6回新潟ゲノム医学研究会)

布川綾子, 渡部雄一郎, 村竹辰之, 金子尚史, 福井直樹, 奈良康, 染矢俊幸

新潟医学会雑誌 2007.6

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ニューレグリン1のELISA法の確立とその統合失調症病態診断への応用可能性

澁谷雅子, 小見笑子, 渡部雄一郎, 坂井美和子, 尾崎美和子, 染矢俊幸, 那波宏之

日本生物学的精神医学会プログラム・講演抄録 2007

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トリプトファン水酸化酵素1(TPH1)遺伝子と統合失調症との関連研究

渡部雄一郎, 布川綾子, 金子尚史, 染矢俊幸

日本生物学的精神医学会プログラム・講演抄録 2007

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カテコール‐O‐メチル転移酵素(COMT)遺伝子の機能的多型と統合失調症との関連研究

布川綾子, 渡部雄一郎, 金子尚史, 村竹辰之, 小泉暢大栄, 染矢俊幸

日本生物学的精神医学会プログラム・講演抄録 2007

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NRG1と統合失調症の大規模サンプルを用いた遺伝子関連解析

池田匡志, 高橋長秀, 齋藤真一, BRANKO Aleksic, 渡部雄一郎, 布川綾子, 山之内芳雄, 北島剛司, 木下葉子, 岸太郎, 川島邦裕, 橋本亮太, 氏家寛, 稲田俊也, 染矢俊幸, 尾崎紀夫, 岩田仲生

日本生物学的精神医学会プログラム・講演抄録 2007

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1 無床総合病院精神科におけるコンサルテーション・リエゾン活動 : 非常勤医としての経験から(第8回新潟GHP研究会)

渡部雄一郎, 染矢俊幸

新潟医学会雑誌 2006.10

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3 神経精神症状に対してミルナシプランの単剤投与が奏効した進行性核上性麻痺の1例(第8回新潟GHP研究会)

横山裕一, 渡部雄一郎, 小澤鉄太郎, 今村徹, 福井直樹, 高橋誠, 染矢俊幸

新潟医学会雑誌 2006.10

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ErbB3遺伝子と統合失調症の関連研究

福井直樹, 渡部雄一郎, 村竹辰之, 金子尚史, 布川綾子, 北村秀明, 染矢俊幸

神経化学 2006.8

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新生仔期PCP投与による皮質辺縁系BDNFの増加とPPI異常

高橋誠, 渡部雄一郎, 水野誠, 鍋島俊隆, 染矢俊幸, 那波宏之

神経化学 2006.8

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腫瘍壊死因子(TNF-α)遺伝子のプロモーター多型と統合失調症との関連研究

布川綾子, 渡部雄一郎, 村竹辰之, 金子尚史, 福井直樹, 奈良康, 染矢俊幸

神経化学 2006.8

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3 Risperidone投与中に水中毒から悪性症候群と横紋筋融解症を呈した統合失調症の1例(I.一般演題,第7回新潟GHP研究会)

渡部雄一郎, 小林慎一, 熊谷敬一, 山本佳子, 田中敏春, 藤島直人, 内藤明彦, 染矢俊幸

新潟医学会雑誌 2006.2

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7 サイトカイン・神経栄養因子の遺伝子多型と統合失調症との関連研究(I.一般演題,第5回新潟ゲノム医学研究会)

渡部雄一郎, 福井直樹, 金子尚史, 村竹辰之, 染矢俊幸

新潟医学会雑誌 2005.11

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5 慢性期統合失調症患者に対する抗精神病薬減量化の試み(I.一般演題,平成16年度新潟精神医学会)

渡部雄一郎, 川室優, 染矢俊幸

新潟医学会雑誌 2005.10

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統合失調症の分子病態 EGFとIL-1はドーパミン性ニューロンに対し神経栄養活性を示すが後に認識異常を起こす(Neurotrophic activity of EGF and IL-1 on dopaminergic neurons and later cognitive abnormalities)

那波宏之, 岩倉百合子, 水野誠, 津田法子, 鄭英君, 渡部雄一郎, 染矢俊幸

神経化学 2005.8

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XBP1遺伝子と統合失調症の関連研究

福井直樹, 天金秀樹, 村竹辰之, 金子尚史, 渡部雄一郎, 染矢俊幸

日本生物学的精神医学会プログラム・講演抄録 2005

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上皮成長因子(EGF)の機能的一塩基多型と統合失調症との関連研究

渡部雄一郎, 福井直樹, 村竹辰之, 金子尚史, 染矢俊幸

日本生物学的精神医学会プログラム・講演抄録 2005

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認知障害モデル動物とその分子メカニズム統合失調症との関連脳発達期における神経栄養因子作用撹乱とその後の認知行動異常統合失調症との関連性(Animal modeling of cognitive impairments: Their molecular mechanisms and implication in schizophrenia: Perinatal Neurotrophic Perturbation and Later Cognitive Deficits: Implication in

那波宏之, 任海学, 津田法子, 渡部雄一郎, 水野誠

神経化学 2004.8

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白血病阻害因子の脳内投与によるドパミン・シグナルおよび潜在制止の異常(Central Administration of Leukemia Inhibitory Factor Disrupts Dopaminergic Signaling and Latent Inhibition)

渡部雄一郎, 武井延之, 柿田明美, 染矢俊幸, 那波宏之

神経化学 2004.8

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幼少期Interleukin-1α末梢投与により成熟後に引き起こされるラットの行動異常(Peripheral Administration of Interleukin-1α To Rat Pups Impairs Cognitive/Behavioral Development)

任海学, 津田法子, 渡部雄一郎, 那波宏之

神経化学 2004.8

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7 白血病阻害因子のラット脳内投与による認知・行動変化(I.一般演題,平成15年度新潟精神医学会)

渡部雄一郎, 橋本慎也, 水野誠, 那波宏之, 染矢俊幸

新潟医学会雑誌 2004.7

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11)Zung自己記入式抑うつ評価尺度及び不安評価尺度の臨床的意義について（ I.一般演題, 新潟精神医学会）

渡部雄一郎, 坂井美和子, 塩入俊樹, 細木俊宏, 染矢俊幸

新潟医学会雑誌 2001.6

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9）精神分裂病患者出生の季節変動 : 予備的研究（平成10年度新潟大学医学部精神医学教室同窓会集談会）

渡部雄一郎, 村竹辰之, 金子尚史, 鈴木保穂, 和泉貞次, 内藤明彦, 桑原秀樹, 馬場正彦

新潟医学会雑誌 1999.2

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Research Projects

Complehensive analysis of de novo variants in families with schizophrenia

Grant number：24K10703

2024.4 - 2027.3

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

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Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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統合失調症患者・両親トリオの全エクソーム解析を起点としたリスク遺伝子の同定

Grant number：19K08067

2019.4 - 2022.3

System name：科学研究費助成事業基盤研究(C)

Research category：基盤研究(C)

Awarding organization：日本学術振興会

渡部雄一郎

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Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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統合失調症患者のセルフスティグマ低減および就労意識向上を目的としたメソッドの確立

Grant number：17K12447

2017.4 - 2020.3

System name：科学研究費助成事業基盤研究(C)

Research category：基盤研究(C)

Awarding organization：日本学術振興会

吉井初美, 萬代望, 渡部雄一郎, 内田知宏, 上埜高志

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Grant amount：\3770000 （ Direct Cost: \2900000 、 Indirect Cost：\870000 ）

本研究は、就労をめざす統合失調症を有する人を対象に、セルフスティグマ低減を目的とした心理教育（5回セッション）を受けていただき、その前後に、セルフスティグマを中心とした抑うつなどのアンケート調査を実施する事によって効果を検証するものである。
昨年度までに心理教育やアンケート調査の内容を確定し倫理審査の準備を進めてきた。
今年度は、本学及び対象施設（1か所の就労支援事業所）の倫理審査委員会から承認を得て調査を開始した。そして同意の得られた対象者6名に対して、アンケート調査を実施し、5名の方に心理教育を受けていただいた。この間、有害事象が発生することもなく研究を継続できている。
また、他の施設（1か所の精神科デイケア）においても倫理審査の手続きを終え審査中であり、2か所の他施設（精神科デイケアと就労支援事業所）に研究協力依頼中である。

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Search for schizophrenia risk gene based on whole-exome sequencing of parent-affected offspring trios, and gene expression analysis of postmortem brains

Grant number：16K10185

2016.4 - 2019.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

Watanabe Yuichiro

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Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

Aim: Rare variations are suggested to play a role in the genetic etiology of schizophrenia, and to further investigate their role, we performed a three-stage study. Methods: First, we performed whole-exome sequencing (WES) of two parent-affected offspring trios. Second, we sequenced the FBXO18 coding region in 96 patients. Third, we tested rare non-synonymous FBXO18 variations for association with schizophrenia in 1,376 patients and 1,496 controls. Results: A rare frameshift variation (L116fsX) in the FBXO18 gene was recurrently identified by WES in both trios. Sequencing FBXO18 coding regions, we detected three rare non-synonymous variations (V15L, L116fsX and V1006I). However, these rare FBXO18 variations were not significantly associated with and schizophrenia in the case-control study. Conclusion: Our present study does not provide evidence for the contribution of rare non-synonymous FBXO18 variations to the genetic etiology of schizophrenia in the Japanese population.

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Whole-exome sequencing in three families with affected siblings

Grant number：25461724

2013.4 - 2016.3

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

Watanabe Yuichiro

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Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

To investigate the role of rare inherited variations, we performed whole-exome sequencing (WES) in three families, each with two affected siblings. We also performed a three-stage follow-up case-control study in a Japanese population with a total of 2617 patients and 2396 controls. WES identified 15 rare truncating variations that were variously present in the two affected siblings in each family. In the follow-up study, four variations (NWD1 W169X, LCORL R7fsX53, CAMK2B L497fsX497, and C9orf89 Q102X) had a higher mutant allele frequency in patients compared with controls, although these associations were not significant in the combined population, which comprised the first-, second- and third-stage populations. These results do not support a contribution of the rare truncating variations identified in the three families to the genetic etiology of schizophrenia.

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Genetic research of schizophrenia and autism

Grant number：23791312

2011 - 2012

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Research category：Grant-in-Aid for Young Scientists (B)

Awarding organization：Japan Society for the Promotion of Science

WATANABE Yuichiro

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Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

MicroRNAs may play a role in the pathophysiology of schizophrenia and autism spectrum disorders (ASD). To explore risk variations for schizophrenia and ASD, we resequenced MIR137 and performed an association analysis in 1,502 Japanese individuals. By resequencing, we detected four sequence variations in the 5' and 3' flanking regions. These variations did not associate with schizophrenia and ASD. Our resequencing and association analysis of MIR137 failed to find risk variations for schizophrenia and ASD.

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Consciousness survey concerning schizophrenia of parents who have junior high school student and high school student and development of educational enlightenment media

Grant number：22592581

2010 - 2012

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

YOSHII Hatsumi, AKAZAWA Kouhei, TERASIMA Takeshi, KITAMURA Hideaki, WATANABE Yuichiro, GOTO Masahiro

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Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

The knowledge and consciousness concerning schizophrenia was surveyed to parents of the junior and senior high school student. In addition, it had correct knowledge concerning schizophrenia, and an educational enlightenment media to promote the help desire action were made. The program resulted in an improvement in basic knowledge of schizophrenia, discrimination of schizophrenia symptoms, and discrimination of prodromal symptoms (P<0.001 for all). After the education program, the rate of parents who sought medical help within 1 week was significantly higher for sleeplessness and social withdrawal and strange behavior.

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Comprehensive genetic analysis of CABIN1 in schizophrenia

Grant number：21791114

2009 - 2010

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Research category：Grant-in-Aid for Young Scientists (B)

Awarding organization：Japan Society for the Promotion of Science

WATANABE Yuichiro

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Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

The gene encoding calcineurin binding protein 1 (CABIN1) is a promising candidate gene for schizophrenia. To assess whether CABIN1 is implicated in vulnerability to schizophrenia, we conducted a case-control association study between CABIN1 and schizophrenia. The results revealed no evidence of an association between CABIN1 and schizophrenia using 11 tagging single nucleotide polymorphisms and a copy number variation. Our results suggest that CABIN1 may not confer increased susceptibility for schizophrenia.

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Copy number variation and risk of schizophrenia : a genome-wide analysis in a multiplex pedigree

Grant number：21791116

2009 - 2010

System name：Grants-in-Aid for Scientific Research

Research category：Grant-in-Aid for Young Scientists (B)

Awarding organization：Japan Society for the Promotion of Science

KANEKO Naoshi, WATANABE Yuichiro, NUNOKAWA Ayako, SOMEYA Toshiyuki

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Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

We conducted a genome-wide copy number variation (CNV) screening in a large multiplex schizophrenia pedigree and performed a follow up case-control study. In screening using microarray method, we found a CNV which potentially co-segregated with schizophrenia. We analyzed This CNV by means of a TaqMan real-time PCR assay and found complete deletions of CNVs in five of six affected individuals and an individual with affection status of unknown. We also conducted a case-control study in 627 patients of schizophrenia and 620 healthy controls. There was no significant association between complete deletions of the CNVs and schizophrenia. Taken together, these results suggest that the CNV may not confer increased susceptibility to schizophrenia.

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Spectroscopy Genomics : Exploring an Effect of Single Nucleotide Polymorphism on Brain Metabolites as Intermediate Phenotypes of Schizophrenia

Grant number：19591343

2007 - 2008

System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Research category：Grant-in-Aid for Scientific Research (C)

Awarding organization：Japan Society for the Promotion of Science

KITAMUR Hideaki, SHI0IRI Toshiki, WATANABE Yuichiro

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Grant amount：\3120000 （ Direct Cost: \2400000 、 Indirect Cost：\720000 ）

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統合失調症におけるサイトカイン・神経栄養因子遺伝子の解析

Grant number：18790825

2006 - 2007

System name：科学研究費助成事業若手研究(B)

Research category：若手研究(B)

Awarding organization：日本学術振興会

渡部雄一郎

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Grant amount：\3500000 （ Direct Cost: \3500000 ）

【目的】サイトカインあるいは神経栄養因子の遺伝子は統合失調症の候補遺伝子として注目されている。しかし、これらの候補遺伝子については報告により必ずしも一致した結果が得られていない。そこで今回我々は、サイトカイン・神経栄養因子遺伝子が統合失調症の疾患感受性遺伝子であるか否かを明らかにするために、日本人集団を対象とした関連研究を行った。
【方法】対象はDSM-IVにより統合失調症と診断された者536人(男性281人、平均年齢40.1[SD 14.2]歳)、および精神疾患既往歴のない健常対象者510人(男性275人、平均年齢37.4[SD 10.2]歳)である。本研究は新潟大学医学部遺伝子倫理審査委員会の承認を得ており、対象者には研究について十分な説明を行い事前に書面にて同意を得ている。
先行研究で関連を認めた多型に加えHapMapデータに基づいて選択したinterleukin 2 (IL2)遺伝子の3多型およびIL4遺伝子の4多型についてTaqMan法により遺伝子型判定を行った。
【結果】解析した7多型については、遺伝子型、アレル、ハプロタイプ頻度のいずれも両群間で有意な差を認めなかった。
【考察】日本人においては、これらのIL2およびIL4遺伝子と統合失調症との関連は否定的であり、先行研究との結果の相違は民族差を反映したものと考えられる。ただし、第2種の過誤の可能性を完全に否定することはできず、さらにサンプル・サイズを増やした研究やメタ解析が望まれる。

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Teaching Experience

健康スポーツ科学講義

2012
Institution name：新潟大学
健康と医学

2010

-

2012
Institution name：新潟大学