Updated on 2025/08/16

写真a

 
NOUNO Kaname
 
Organization
Academic Assembly Institute of Medicine and Dentistry SHIGAKU KEIRETU Professor
Faculty of Dentistry Department of Oral Health and Welfare Professor
Graduate School of Medical and Dental Sciences Oral Health and Welfare Science Oral Health and Welfare Professor
Title
Professor
External link

Degree

  • Doctor (Dental) ( 2005.3   Niigata University )

Research Interests

  • elders

  • Oral function

  • Halitosis

  • Xerostomia, Oral dryness

  • Fluoride

Research Areas

  • Life Science / Social dentistry

Research History

  • Niigata University   School of Oral Health and Welfare, Faculty of Dentistry   Professor

    2021.4

  • Niigata University   Dental Educational Research Development, Master's Program of Oral Health and Welfare Science, Graduate School of Medical and Dental Sciences   Professor

    2021.4

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Professor

    2021.4

  • Niigata University   University Medical and Dental Hospital Dental Health Preventive Dentistry   Lecturer

    2019.11 - 2021.3

  • Niigata University   Graduate School of Medical and Dental Sciences Oral Life Science   Assistant Professor

    2013.1 - 2019.10

  • Niigata University   University Medical and Dental Hospital Oral Health Control   Assistant Professor

    2013.1 - 2019.10

  • Niigata University   Graduate School of Medical and Dental Sciences Oral Life Science   Assistant Professor

    2006.8 - 2012.12

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Education

  • Niigata University   Faculty of Dentistry & Graduate School of Medical and Dental Sciences   Division of Preventive Dentistry

    2001.4 - 2005.3

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    Country： Japan

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  • Niigata University   Faculty of Dentistry   School of Dentistry

    - 2001

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    Country： Japan

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Studying abroad experiences

  • Newcastle University   Visiting Lecturer

    2010.3 - 2010.9

 

Papers

  • Low Salivary IgA Levels Against PAc (361–386) as a Risk Factor for Root Caries in Older Adults Reviewed

    Yu Ichikawa, Noboru Kaneko, Kaung Myat Thwin, Hidenobu Senpuku, Kaname Nohno, Hiroshi Ogawa

    Clinical and Experimental Dental Research   10 ( 4 )   2024.8

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    ABSTRACT

    Objectives

    This study aimed to assess the intricate relationship between salivary IgA antibody levels to PAc (361–386) (PPA), mutans streptococci colonization, and root caries development in older adults.

    Materials and Methods

    This study included 307 participants aged 76 years residing in Niigata city, Japan. Clinical oral examinations were performed at baseline in 2004 and 1 year later, during which the total number of untreated and treated root caries was assessed using the root decayed, filled tooth (DFT) index. The stimulated saliva samples were collected using the spitting method during the baseline survey. Salivary IgA antibody levels to amino acid residues 361–386 of Streptococcus mutans PAc were quantified using an enzyme‐linked immunosorbent assay. Statistical analyses, including the χ<sup>2</sup> test, Mann–Whitney U test, and logistic regressions, were performed to examine the association of increased root DFT with the independent variables.

    Results

    Among the 307 participants (53.1% men), the mean root DFT at baseline was 3.77 ± 3.66, and 36.5% of the study sample exhibited increased root DFT after 1 year with a mean increment of 0.36 ± 0.48. Participants with increase in root DFT after 1 year had significantly higher rates of low PPA levels (≤ 25th percentile) than those without increased root DFT (p = 0.020). Low PPA levels (≤ 25th percentile) were significantly more likely to have an increased risk of root caries development compared with PPA levels &gt; 25th percentile (adjusted OR: 1.88, 95% CI: 1.09–3.25).

    Conclusion

    Low PPA levels and root caries incidence correlated significantly, suggesting that low levels of salivary IgA antibody to PAc (361–386) may serve as a risk factor for increased root caries in older adults.

    DOI： 10.1002/cre2.945

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  • Ten years’ evaluation of periodontal status and its changes among Japanese older adults Reviewed

    Fania Chairunisa, Elastria Widita, Kaung Myat Thwin, Sachiko Takehara, Kaname Nohno, Lisdrianto Hanindriyo, Hideo Miyazaki, Hiroshi Ogawa

    Special Care in Dentistry   2024.7

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Aims

    This study aims to evaluate the periodontal status and its changes among Japanese older adults over a 10‐year period.

    Methods and results

    A total of 206 dentate older adults aged 70 years who completely participated in 10 years of oral examination were included. The community periodontal index (CPI) was used to assess the gingival and periodontal pocket status, while the loss of attachment (LA) scoring system was used to report the extensive LA. A higher score in CPI (Code 3 and Code 4) and more extensive attachment loss were found in a majority of participants. During follow‐up evaluation, mean number of sextants with CPI code 4 remained stable, while CPI code 3 significantly decreased particularly in male participants. Whereas, sextants without attachment loss significantly decreased on average. The mean number of missing sextants significantly increased from 1.1 to 1.9, and 5.8% of subjects had all sextants excluded in the follow‐up.

    Conclusion

    This study indicated that majority of the older people experienced severe periodontal disease and this condition remained stable during 10‐year period. Additionally, the incidence of tooth loss increased as individuals aged. Regular oral care and maintenance are highly recommended for older population.

    DOI： 10.1111/scd.13043

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  • 病院歯科の歯科衛生士による定期的な口腔衛生管理の各手順時間および処置時間の関連要因—Time Spent on Each Care Protocol of Regular Oral Hygiene Management and Factors Related to Preventive Dental Care Time by Dental Hygienists in a Dental Hospital Reviewed

    高野 綾子, 柴田 佐都子, 沖津 佳子, 濃野 要, 葭原 明弘

    口腔衛生学会雑誌 = Journal of dental health : official publication of Japanese Society for Oral Health / 日本口腔衛生学会 編   74 ( 2 )   92 - 98   2024.4

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    Language：Japanese   Publisher：東京 : 日本口腔衛生学会  

    CiNii Books

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    Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I033482614

  • Investigation of orthognathic surgery indicators-combination with index of orthognathic functional treatment needs (IOFTN) and maxillofacial morphometric analysis. Reviewed International journal

    Zhuoyang Zheng, Daichi Hasebe, Daisuke Suda, Naoaki Saito, Daisuke Saito, Jun Nihara, Kaname Nohno, Isao Saito, Tadaharu Kobayashi

    Oral and maxillofacial surgery   2024.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: The aim of this retrospective study was to determine orthognathic surgery indicators for Japanese patients with jaw deformities using both Index of Orthognathic Functional Treatment Needs (IOFTN) and maxillofacial morphometric analysis. SUBJECTS AND METHODS: The subjects were 89 patients treated with orthognathic surgery and 92 patients treated with orthodontic treatment alone, and were classified as class I, II, or III according to the ANB angle. Based on the results for IOFTN and the results of cephalometric analysis, the indication criteria for orthognathic surgery were examined. RESULTS: In IOFTN analysis, none of patients in the orthognathic surgery group were classified as category 1 or 2, while 48% of the patients in the orthodontic treatment group were classified as category 4 or 5. The results of the cephalometric analysis of patients in classified categories 4 and 5 showed that the orthognathic surgery group had significantly greater lateral mandibular deviation in Class I cases, significantly more severe degree of mandibular retrusion in Class II cases, and significantly more severe degree of mandibular prognathism in Class III cases. The results of the logistic regression analysis showed that IOFTN was a common variable as an indication criterion for orthognathic surgery, and several different variables were also selected from the cephalometric measurements in each group. CONCLUSION: IOFTN is a highly sensitive and useful indicator as a criterion for orthognathic surgery. However, in the choice of treatment strategy, maxillofacial morphometric analyses and the patient's desired goal are important.

    DOI： 10.1007/s10006-024-01243-0

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  • Gonial angle and late implant loss: A retrospective clinical study Reviewed

    Tahrim Akter, Makiko Takashima, Yoshiaki Arai, Nanaka Matsuzaki, Yuta Yamazaki, Kaname Nohno

    Journal of Prosthodontic Research   2024

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    Publishing type：Research paper (scientific journal)   Publisher：Japan Prosthodontic Society  

    DOI： 10.2186/jpr.jpr_d_23_00267

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  • 定期的歯科介入が行われている施設利用知的障害者の支援必要度と口腔保健支援状況との関連性 Reviewed

    吉田 歩未, 中村 由紀, 大島 邦子, 中島 努, 笹川 祐輝, 濃野 要, 早崎 治明

    口腔衛生学会雑誌   73 ( 4 )   260 - 269   2023.10

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  • 二段階口蓋形成手術法における軟口蓋形成術前の後方裂幅と乳歯列期咬合関係の関連 Reviewed

    大湊 麗, 小野 和宏, 児玉 泰光, 結城 龍太郎, 永井 孝宏, 小林 亮太, 市川 佳弥, 丹原 惇, 佐藤 真由美, 濃野 要, 飯田 明彦, 若槻 華子, 宮田 昌幸, 小林 正治, 齋藤 功, 高木 律男, 冨原 圭

    日本口蓋裂学会雑誌   48 ( 2 )   184 - 184   2023.4

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    Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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  • Masseter muscle cross-sectional area and late implant failure: A case-control study. Reviewed International journal

    Makiko Takashima, Yoshiaki Arai, Nanaka Matsuzaki, Yuta Yamazaki, Hideyoshi Nishiyama, Kaname Nohno

    Clinical implant dentistry and related research   25 ( 2 )   313 - 320   2023.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Occlusal overload is considered to be one of the causes of late implant failure. However, it is unclear whether the magnitude of the patient's occlusal force is a risk factor for late implant failure. PURPOSE: This case-control study aimed to clarify the association between the cross-sectional area (CSA) of the masseter muscle and late implant failure. METHODS: This case-control study was limited to implant-supported fixed prostheses. We compared cases with at least one late implant failure (n = 25 patients) to controls (n = 82 patients) without implant failure. Patients were matched by age, sex, year of surgery, jaw and tooth type, and bone graft. Log-rank and Cox proportional hazard regression analyses were used to identify possible risk factors for late implant failure. RESULTS: The incidence of late implant failure was significantly associated with masseter muscle CSA ≥504.5 mm2 (hazard ratio: 4.43; 95% CI: 1.82-10.79; p < 0.01). CONCLUSION: Higher masseter muscle CSA increases the risk of late implant failure.

    DOI： 10.1111/cid.13189

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  • 当科における過去10年間の入院加療を要した顎口腔領域の感染性疾患症例の臨床的検討 Reviewed

    齋藤 夕子, 黒川 亮, 永井 孝宏, 上野山 敦士, 池田 順行, 児玉 泰光, 濃野 要, 冨原 圭

    有病者歯科医療   32 ( 2 )   66 - 71   2023.3

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    Language：Japanese   Publisher：(一社)日本有病者歯科医療学会  

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  • Prevalence and Cause of Enamel Hypoplasia in Primary Teeth among 1-year-old Japanese Children Reviewed

    Akane Miyamoto, Kumiko Minagawa, Kaname Nohno, Noboru Kaneko, Yu Ichikawa, Takashi Hoshino, Harue Ito, Akihiro Yoshihara

    Open Dentistry Journal   17 ( 1 )   2023

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.2174/18742106-v17-230303-2022-93

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  • Characteristics of medication-induced xerostomia and effect of treatment. Reviewed International journal

    Kayoko Ito, Naoko Izumi, Saori Funayama, Kaname Nohno, Kouji Katsura, Noboru Kaneko, Makoto Inoue

    PloS one   18 ( 1 )   e0280224   2023

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: Side-effects of medications cause xerostomia. There have been cases where a medication has been discontinued owing to its severe side-effects. Therefore, the xerostomia must be treated to ensure that the primary disease is managed effectively. This study analyzed the actual status of patients with medication-induced xerostomia and investigates factors associated with its improvement. METHODS: This study assessed 490 patients diagnosed with medication-induced xerostomia who had an unstimulated salivary flow of ≤0.1 mL/min and received treatment for xerostomia at a xerostomia clinic. Patient age, sex, medical history, medications used, disease duration of xerostomia, and psychological disorders were recorded. The anticholinergic burden was assessed using the Anticholinergic Cognitive Burden scale. The unstimulated salivary flow was measured by the spitting method. According to their symptoms and diagnoses, the patients were introduced to oral lubricants, instructed on how to perform massage, and prescribed Japanese herbal medicines, and sialogogues. Factors associated with the subjective improvement of xerostomia and objective changes in the salivary flow rate were recorded at six months. RESULTS: Xerostomia improved in 338 patients (75.3%). The improvement rate was significantly lower in patients with psychiatric disorders (63.6%) (P = 0.009). The improvement rate decreased as more anticholinergics were used (P = 0.018). However, xerostomia improved in approximately 60% of patients receiving three or more anticholinergics. The unstimulated salivary flow increased significantly more in patients who reported an improvement of xerostomia (0.033±0.053 mL/min) than in those who reported no improvement (0.013±0.02 mL/min) (P = 0.025). CONCLUSION: Xerostomia treatment improved oral dryness in 75.3% of patients receiving xerogenic medications in this study. If xerostomia due to side-effects of medications can be improved by treatment, it will greatly contribute to the quality of life of patients with xerogenic medications and may reduce the number of patients who discontinue medications.

    DOI： 10.1371/journal.pone.0280224

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  • Clinical and Microbial Evaluation of Dental Caries Status and Associated Factors Among Primary Schoolchildren in Myanmar: A Cross-Sectional Study Reviewed

    Kaung Myat Thwin, Tin Zar Tun, Noboru Kaneko, Kaname Nohno, Hiroshi Ogawa

    Asia Pacific Journal of Public Health   101053952211393 - 101053952211393   2022.11

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    Publishing type：Research paper (scientific journal)   Publisher：SAGE Publications  

    The study aimed to investigate the prevalence and associated factors of dental caries on primary teeth and to evaluate the cariogenic bacteria in dental plaque and saliva among Myanmar schoolchildren. A cross-sectional study was undertaken among 264 schoolchildren from three primary schools in the urban area of Yangon city in 2019. Clinical oral examinations, caries risk tests, and questionnaire surveys were conducted. Overall caries prevalence was 84.1% with a mean decayed, missing, filled primary teeth (dmft) count of 5.84 ± 4.57. Children’s caries experience and debris scores were significantly associated with their bacteria score level. Father’s occupation was significantly associated with caries prevalence ( P = .024) and dmft ( P = .021). Father’s occupation, snack types, habit of eating sweet food combinations, drink types, and debris score were five significant predictors of dental caries in our study. Dental caries is currently a public health problem among Myanmar children. Caries experience and oral hygiene status were strongly influenced by cariogenic bacteria.

    DOI： 10.1177/10105395221139347

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    Other Link： http://journals.sagepub.com/doi/full-xml/10.1177/10105395221139347

  • Effects of Interval Walking Training on Oral Health Status in Middle-Aged and Older Adults: A Case-Control Study. Reviewed International journal

    Tasuku Yoshimoto, Yoko Hasegawa, Mayuka Furihata, Akihiro Yoshihara, Masako Shiramizu, Ma Therese Sta Maria, Shoko Hori, Mayuko Morikawa, Pinta Marito, Noboru Kaneko, Kaname Nohno, Hiroshi Nose, Shizue Masuki, Takahiro Ono

    International journal of environmental research and public health   19 ( 21 )   2022.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    The purpose of this study was to determine the effect of walking training "Interval Walking Training (IWT)" on oral health status. Participants were divided into two groups: an exercise intervention group and a non-intervention group (control). The intervention group consisted of 59 subjects (20 males, 39 females) aged 50 years or older who participated in the IWT program in Matsumoto from 2019 to April 2022. The control group consisted of 33 subjects (14 males and 19 females) aged 50 years or older who have visited Niigata University Medical and Dental Hospital and agreed to participate in the study. The intervention group underwent walking training (interval walking training) for at least 5-6 months. The walking training consisted of five sets of fast walking above 70% peak aerobic capacity for walking (VO2peak) for 3 min, followed by 3 min of slow walking at ~40% VO2 peak per day for more than four days/week. The oral health status was evaluated for the number of teeth, occlusal force, salivary occult blood, masticatory performance, and tongue pressure. A total of 57 participants were analyzed in the intervention group (18 males and 39 females, age: 66.7 ± 0.8 (mean ± S.E.) years) and 33 participants in the control group (14 males and 19 females, age: 74.5 ± 1.1 (mean ± S.E.) years). There were no significant differences in gender, salivary occult blood, tongue pressure, masticatory performance, or occlusal force between the two groups at the start of the intervention (p = 0.36, p = 0.48, p = 0.42, p = 0.58, and p = 0.08, respectively by unpaired t-test or χ2 test). On the other hand, there were significant differences in age and BMI, with a trend toward lower age and higher BMI in the intervention group (p &lt; 0.001 and p &lt; 0.001, respectively, by unpaired t-test). In terms of rate of change, the intervention group showed a significant increase in occlusal force (F = 4.5, p = 0.04, ANCOVA) and a significant decrease in BMI (F = 7.3, p = 0.009, ANCOVA). No significant differences were observed in the other measured items. It was found that walking training in both middle-aged and older people does not only affect the physical aspect of weight loss but may help maintain and improve the occlusal force.

    DOI： 10.3390/ijerph192114465

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  • Examination of factors affecting condylar bone changes following surgical-orthodontic treatment. Reviewed International journal

    Satoshi Endo, Kanae Niimi, Yusuke Kato, Kaname Nohno, Daichi Hasebe, Takafumi Hayashi, Isao Saito, Tadaharu Kobayashi

    Cranio : the journal of craniomandibular practice   1 - 11   2022.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: To identify factors affecting condylar bone changes following surgical-orthodontic treatment. METHODS: A total of 200 patients with dentofacial deformities were classified into skeletal Classes I, II, and skeletal Class III groups consisting of 61 and 139 subjects, respectively. Temporomandibular joints (TMJs) were evaluated using clinical findings and computed tomography images before treatment, immediately before surgery, and 6 months after surgery. RESULTS: Condylar bone changes occurred at a significantly higher rate after surgery in both groups. Factors related to condylar bone changes following surgical-orthodontic treatment included skeletal Class I or II, disc displacement, and condylar bone changes before treatment. There were three cases with condylar bone changes after surgery that were diagnosed with condylar resorption and skeletal Class II and anterior disc displacement before surgery. CONCLUSION: Condylar resorption could occur when the load on the condyle increases after orthognathic surgery and exceeds the permissible limit.

    DOI： 10.1080/08869634.2022.2118263

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  • Association of Hyper-Low-Density Lipoprotein and Hypo-High-Density Lipoprotein Cholesterolemia with Low Saliva Flow Rates in Japanese Community-Dwelling Elders Reviewed

    Nana Mizoguchi, Kaname Nohno, Akihiro Yoshihara, Kayoko Ito, Saori Funayama, Hiroshi Ogawa

    International Archives of Otorhinolaryngology   2022.7

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    Publishing type：Research paper (scientific journal)   Publisher：Georg Thieme Verlag KG  

    Abstract

    Introduction The associations of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein (HDL-C) with reduced saliva flow rates have not been previously reported.

    Objective The present study aimed to assess the association of cholesterolemia with reduced saliva flow rates in community-dwelling elderly subjects.

    Methods The present study analyzed 342 participants (170 males and 172 females aged between 78 and 79 years old). Unstimulated salivary flow rate (USFR) was assessed using a cotton roll method. Low-USFR was defined as 0.10 g/30 seconds. Stimulated salivary flow rate (SSFR) was assessed by having the participants chew tasteless gum for 3 minutes. Low-SSFR was defined as 1.0 mL/minute. Blood samples were collected for the measurement of LDL-C, HDL-C, rheumatoid factor, hemoglobin A1c, and creatinine. To assess depression, the General Health Questionnaire 30 was used. A standardized questionnaire was completed, covering the current and previous medications of the participants and smoking status. We stratified the serum LDL-C levels of the participants as normal, moderate or severe hyper-LDL cholesterolemia and serum HDL-C levels as normal or hypo-HDL cholesterolemia. Multivariate logistic regression models were established and low-USFR or low-SSFR were set as dependent variables in the aforementioned models.

    Results After controlling for the effects of the other variables, the odds ratios (ORs) (95% confidence intervals [CIs]) for low-USFR were 2.25 (1.10–4.61) for moderate and 5.69 (1.55–20.8) for severe hyper-LDL cholesterolemia, while that of hypo-HDL cholesterolemia was 3.40 (1.33–8.69). Severe hyper-LDL cholesterolemia was also associated with low-SSFR with an OR of 3.89 (1.39–10.88).

    Conclusion Elderly patients with cholesterolemia have a risk of reduced salivary flow rate.

    DOI： 10.1055/s-0042-1744167

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  • Effect of Locally Delivered Minocycline on the Profile of Subgingival Bacterial Genera in Patients with Periodontitis: A Prospective Pilot Study. Reviewed International journal

    Toshiya Morozumi, Yohei Nakayama, Satoshi Shirakawa, Kentaro Imamura, Kaname Nohno, Takatoshi Nagano, Haruna Miyazawa, Takahiro Hokari, Ryo Takuma, Shuntaro Sugihara, Kazuhiro Gomi, Atsushi Saito, Yorimasa Ogata, Motohiro Komaki

    Biomolecules   12 ( 5 )   2022.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    This prospective pilot study aimed to evaluate the effect of minocycline-HCl ointment (MO), locally delivered as an adjunct to scaling and root planing (SRP), on subgingival microflora. A total of 59 periodontitis patients received SRP as an initial periodontal therapy. In the selected periodontal pockets with probing depths (PD) of 6-9 mm, the sites that exhibited a positive reaction following a bacterial test using an immunochromatographic device were subsequently treated with MO (SRP + MO group, n = 25). No additional treatment was performed at sites showing a negative reaction (SRP group, n = 34). In addition to subgingival plaque sampling, measurement of clinical parameters including PD, clinical attachment level (CAL), bleeding on probing (BOP), plaque index and gingival index (GI) were performed at baseline and 4 weeks after the initial periodontal therapy. The subgingival microflora were assessed by terminal restriction fragment-length polymorphism analysis. Relative to baseline values, the mean scores for PD-, CAL-, BOP-, and GI-sampled sites were significantly decreased post treatment in both groups (p &lt; 0.01). The intra-comparisons showed a significant decrease in the counts of the genera Eubacterium, Parvimonas, Filifactor, Veillonella, Fusobacterium, Porphyromonas, Prevotella, and unknown species in the SRP + MO group (p &lt; 0.05). Inter-comparisons indicated a significant decrease in the genera Veillonella in the SRP + MO group (p = 0.01). Combination therapy of SRP and local MO induced a change in the subgingival microbial community: particularly, the number of Veillonella spp. was markedly reduced.

    DOI： 10.3390/biom12050719

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  • 二段階口蓋形成手術法における幼児期前期の言語管理に関する検討 口蓋化構音と硬口蓋残遺裂の関連性にもとづいて Reviewed

    大湊 麗, 小野 和宏, 児玉 泰光, 結城 龍太郎, 永井 孝宏, 小林 亮太, 小林 孝憲, 飯田 明彦, 濃野 要, 宮田 昌幸, 小林 正治, 齋藤 功, 高木 律男, 冨原 圭

    日本口蓋裂学会雑誌   47 ( 1 )   20 - 29   2022.4

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    Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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  • Oral Health and Nutritional Intake in Community‐Dwelling 90‐Year‐Old Japanese People: A Cross‐Sectional Study Reviewed

    Raksanan Karawekpanyawong, Kaname Nohno, Yu Kubota, Hiroshi Ogawa

    Gerodontology   40 ( 1 )   100 - 111   2022.3

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/ger.12627

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ger.12627

  • Anti-caries and anti-microbial effects of school-based fluoride programs in Myanmar schoolchildren Reviewed

    Kaung Myat Thwin, Wa Than Lin, Noboru Kaneko, Kaname Nohno, Hiroshi Ogawa

    Oral Health and Preventive Dentistry   20   165 - 172   2022.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3290/j.ohpd.b2960285

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  • Factors associated with xerostomia in perimenopausal women Reviewed

    Chizuko Shinohara, Kayoko Ito, Kiyoshi Takamatsu, Mariko Ogawa, Yuka Kajii, Kaname Nohno, Aki Sugano, Saori Funayama, Akira Katakura, Takeshi Nomura, Makoto Inoue

    Journal of Obstetrics and Gynaecology Research   2021.8

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/jog.14963

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jog.14963

  • Radiological imaging features of the salivary glands in xerostomia induced by an immune checkpoint inhibitor Reviewed

    Kouji Katsura, Saori Funayama, Kayoko Ito, Kaname Nohno, Noboru Kaneko, Masaki Takamura, Marie Soga, Taichi Kobayashi, Takafumi Hayashi

    Oral Radiology   37 ( 3 )   531 - 536   2021.7

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    <title>Abstract</title>The clinical features of xerostomia induced by immune checkpoint inhibitors (ICI) are similar to those of Sjögren’s syndrome (SS), whereas the immunohistological and serological features are known to differ from those of SS. However, the radiologic imaging features of salivary glands are not yet well known. We report a case of a 56-year-old male patient diagnosed with ICI-induced xerostomia. The patient underwent various imaging examinations to investigate the condition of the salivary glands, which indicated the following: (1) less specific findings on contrast-enhanced computed tomography, (2) mixed with intermediate and low signal intensity on both <italic>T</italic><sub><italic>1</italic></sub>-weighted and fat-suppressed <italic>T</italic><sub><italic>2</italic></sub>-weighted magnetic resonance imaging and poor “salt and pepper” appearance on magnetic resonance sialography, and (3) multiple ovoid hypoechoic areas with hyperechoic bands without acute sialadenitis on ultrasound. These radiologic imaging findings suggested remarkable lymphocyte infiltration, which could be a characteristic of ICI-induced xerostomia.

    DOI： 10.1007/s11282-020-00480-9

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    Other Link： https://link.springer.com/article/10.1007/s11282-020-00480-9/fulltext.html

  • 地域在宅超高齢者の食事パターンと栄養素摂取量、栄養状態および嚥下状態との関連 Reviewed

    秋山 理加, 濱嵜 朋子, 岩崎 正則, 角田 聡子, 片岡 正太, 茂山 博代, 濃野 要, 葭原 明弘, 小川 祐司, 安細 敏弘, 宮崎 秀夫

    口腔衛生学会雑誌   71 ( 3 )   136 - 146   2021.7

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  • Interaction between and impact of IL-6 genotype and alpha-tocopherol levels on periodontal condition in aging individuals. Reviewed International journal

    Akihiro Yoshihara, Noboru Kaneko, Akane Miyamoto, Kaname Nohno

    Journal of periodontal research   56 ( 1 )   139 - 146   2021.1

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    BACKGROUND AND OBJECTIVES: Few studies have assessed the possible interaction between and impact of IL-6 variants and serum α-tocopherol levels on periodontal condition in older individuals. Here, we assessed the relationship between IL-6 variants and serum α-tocopherol levels on periodontal condition by considering effect modification. MATERIAL AND METHODS: Among the study participants, 359 who were 71 years of age underwent a dental examination, biochemical analysis, and interview. After dividing the participants into tertiles based on serum α-tocopherol levels, we conducted Poisson regression analysis to compare the prevalence rate ratio (PRR) for periodontal disease markers with the IL-6 genotype (rs1800796) based on each tertile adjusted by the number of teeth present (offset). RESULTS: The PRRs of the IL-6 genotype for periodontal condition (probing pocket depth [PPD], clinical attachment level [CAL], and bleeding on probing [BOP]) which were adjusted by the number of teeth present (offset) were 1.17 (P < .001), 1.37 (P < .001), and 1.08 (P = .048), respectively. In addition, a significant association was found between the reciprocal number of PRRs of the IL-6 genotype and three serum α-tocopherol levels. The adjusted PRRs (± standard error) of the IL-6 genotypes for PPD were 0.48 (0.12) for the first group (P < .001), 1.54 (0.04) for the second group (P < .001), and 2.11 (0.03) for the third group (P < .001); similar tendencies were seen for CAL and BOP. CONCLUSION: The results of this study suggest a potential association between the IL-6 genotype and periodontal condition in relation to serum antioxidant concentrations.

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  • Efficacy of erbium: YAG laser for regenerative surgical treatment of peri-implantitis: Clinical, microbiological, and biomarker analyses

    Atsuhiko Yamamoto, Takehiko Kubota, Yasutaka Komatsu, Kaname Nohno, Tadashi Yasuda, Tsurayuki Takahashi, Ryuboku Torikata, Norimasa Tsumori, Toshiaki Shibutani, Makoto Umeda, Hiromasa Yoshie

    International Journal of Periodontics and Restorative Dentistry   41 ( 2 )   187 - 192   2021

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    DOI： 10.11607/prd.4071

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  • Reducing bacterial counts around the abutment following professional mechanical plaque removal at the implant bridge: A randomized crossover comparison of removing or not removing the superstructure Reviewed

    Yoshiaki Arai, Mutsumi Inanobe-Takatsuka, Makiko Takashima, Shin Ogawa, Atsushi Kawamura, Kaname Nohno, Katsumi Uoshima

    Journal of Prosthodontic Research   65 ( 1 )   91 - 96   2021

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    DOI： 10.2186/jpr.JPOR_2019_431

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  • The oral microbiome of healthy Japanese people at the age of 90 Reviewed

    Yoshiaki Nomura, Erika Kakuta, Noboru Kaneko, Kaname Nohno, Akihiro Yoshihara, Nobuhiro Hanada

    Applied Sciences (Switzerland)   10 ( 18 )   2020.9

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    DOI： 10.3390/APP10186450

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  • Interaction between beta-3 adrenergic receptor genotype and environmental factors on periodontal progression. Reviewed

    Yoshihara A, Kaneko N, Nohno K, Iwasaki M

    Journal of clinical periodontology   46 ( 6 )   623 - 630   2019.6

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  • 地域在宅超高齢者の食事パターンと栄養状態、栄養素摂取量および嚥下との関連 Reviewed

    濱嵜 朋子, 岩崎 正則, 角田 聡子, 片岡 正太, 濃野 要, 葭原 明弘, 小川 祐司, 安細 敏弘, 宮崎 秀夫

    口腔衛生学会雑誌   69 ( 増刊 )   161 - 161   2019.4

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  • 味覚外来患者統計および亜鉛補充療法の効果 Reviewed

    船山さおり, 伊藤加代子, 濃野 要, 井上 誠

    口腔・咽頭科   32 ( 1 )   42 - 47   2019.3

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  • Relationships between changes in posterior occlusal support and risk of protein-energy malnutrition among the Japanese community dwelling elderly Reviewed

    Nonomura A, Nohno K, Ogawa H

    Dentistry   9 ( 2 )   1 - 7   2019.2

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  • 職域における歯科健診と個別保健指導による行動変容 Reviewed

    金子昇, 葭原 明弘, 濃野 要, 山賀 孝之, 財津 崇, 川口 陽子, 宮崎 秀夫

    口腔衛生会誌 J Dent Hlth69   69 ( 1 )   27 - 33   2019.1

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  • Effectiveness of an erbium-doped: yttrium, aluminum and garnet laser for treatment of peri-implant disease: Clinical, microbiological, and biochemical marker analyses. Reviewed International journal

    Komatsu Y, Kubota T, Yasuda T, Takahashi T, Yamamoto A, Kono T, Tabata H, Nohno K, Shibutani T, Umeda M, Yoshie H

    Journal of clinical and experimental dentistry   10 ( 10 )   e970 - e978   2018.10

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    Background: The effectiveness of an erbium-doped: yttrium, aluminum and garnet (Er: YAG) laser (EYL) for the treatment of peri-implant disease (PID) remains unclear. The aim of this study was to compare non-surgical EYL therapy for PID with locally delivered minocycline hydrochloride (MC) ointment therapy by evaluating clinical, microbiological, and biochemical markers. Material and Methods: Thirty-seven patients with PID were randomly assigned to either the EYL group (n = 18) or the MC group (n = 19). The clinical, microbiological, and biochemical markers at baseline and at 1 and 3 months after treatment were compared between the two groups. Subgingival plaque and peri-implant crevicular fluid (PICF) were collected from the diseased pockets. Results: In the EYL group, probing pocket depth (PPD) was significantly decreased after treatment when compared with baseline. On the other hand, in the MC group, there was no significant decrease in PPD after treatment. Specific bacteria associated with PID were not determined. The counts of both Gram-positive and -negative species did not significantly decrease in the EYL group at 3 months after treatment. In the MC group, the counts of almost all bacterial species were significantly decreased after treatment. Biochemical marker analysis of PICF revealed significantly lower levels of metalloproteinase (MMP)-9 in the EYL group, as compared with the MC group at 3 months after treatment (p= 0.009). Conclusions: Non-surgical therapy with an EYL for PID was clinically effective, with decreased MMP-9 levels in PICF, which may lead to reduced peri-implant tissue destruction. Key words:Er: YAG laser; peri-implant disease; biomarker; peri-implant crevicular fluid.

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  • A comparable study of combinational regenerative therapies comprising enamel matrix derivative plus deproteinized bovine bone mineral with or without collagen membrane in periodontitis patients with intrabony defects. Reviewed

    Kubota T, Nemoto Y, Nohno K, Nezu A, Morozumi T, Yoshie H

    Open Journal of Stomatology   8   277 - 286   2018.9

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    DOI： 10.4236/ojst.2018.89026

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  • Hyposalivation and 10-year all-cause mortality in an elderly Japanese population Reviewed

    Masanori Iwasaki, Wenche S. Borgnakke, Akihiro Yoshihara, Kayoko Ito, Hiroshi Ogawa, Kaname Nohno, Misuzu Sato, Kumiko Minagawa, Toshihiro Ansai, Hideo Miyazaki

    Gerodontology   35 ( 2 )   87 - 94   2018.6

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    DOI： 10.1111/ger.12319

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  • Relationship between vitamin D receptor gene polymorphism and susceptibility to chronic kidney disease and periodontal disease in community-dwelling elderly. Reviewed International journal

    Akihiro Yoshihara, Noboru Kaneko, Masanori Iwasaki, Kaname Nohno, Hideo Miyazaki

    Journal of clinical periodontology   45 ( 6 )   672 - 679   2018.6

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    OBJECTIVES: The aim of this study was to investigate the possible correlation between vitamin D receptor (VDR) gene polymorphism and susceptibility to chronic kidney disease (CKD) and periodontal disease. MATERIAL AND METHODS: This study analysed 345 participants, who were all 79 years of age. Kidney function levels were determined based on the estimated glomerular filtration rate (eGFR; non-reduced function: ≥60 and reduced function: <60 ml min-1  1.73 m-2 ). VDR TaqI genotyping was also studied. We calculated the periodontal inflamed surface area (PISA). After classifying participants into quartile groups according to eGFR or PISA values, the subjects were then split into two groups (highest quartile versus the other three groups combined). Multiple logistic regression analysis was performed to evaluate the odds ratios between the eGFR and VDR TaqI genotype with the different PISA groups. The eGFR was set as the dependent variable while the VDR TaqI genotype, HbA1C, gender, smoking habits and body mass index were defined as independent variables. RESULTS: A significant association was observed between the VDR TaqI genotype and eGFR in the PISA high group (odds ratio = 3.97, p = .027). CONCLUSION: Study results suggest that VDR TaqI genotype might be associated with CKD during inflammatory conditions caused by periodontal disease.

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  • 在宅超高齢者の栄養状態と栄養素摂取量との関連 Reviewed

    濱嵜 朋子, 岩崎 正則, 角田 聡子, 片岡 正太, 濃野 要, 葭原 明弘, 安細 敏弘, 宮崎 秀夫

    口腔衛生学会雑誌   68 ( 増刊 )   113 - 113   2018.4

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  • 口腔乾燥症診断チャートの開発 Reviewed

    伊藤加代子, 船山さおり, 勝良剛詞, 金子 昇, 濃野 要, 池 真樹子, 井上 誠

    日摂食リハ会誌   22 ( 2 )   153 - 160   2018

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  • Effects of Antimicrobial Photodynamic Therapy and Local Administration of Minocycline on Clinical, Microbiological, and Inflammatory Markers of Periodontal Pockets: A Pilot Study Reviewed

    Takahiro Hokari, Toshiya Morozumi, Yasutaka Komatsu, Taro Shimizu, Toshiaki Yoshino, Maki Tanaka, Yoshie Tanaka, Kaname Nohno, Takehiko Kubota, Hiromasa Yoshie

    International Journal of Dentistry   2018   1748584   2018

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    DOI： 10.1155/2018/1748584

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  • Clinical and CBCT evaluation of combined periodontal regenerative therapies using enamel matrix derivative and deproteinized bovine bone mineral with or without collagen membrane Reviewed

    Yasuko Nemoto, Takehiko Kubota, Kaname Nohno, Arata Nezu, Toshiya Morozumi, Hiromasa Yoshie

    International Journal of Periodontics and Restorative Dentistry   38 ( 3 )   373 - 381   2018

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    DOI： 10.11607/prd.3288

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  • Expression of neprilysin in periodontitis-affected gingival tissues Reviewed

    A. Nezu, T. Kubota, S. Maruyama, M. Nagata, K. Nohno, T. Morozumi, H. Yoshie

    ARCHIVES OF ORAL BIOLOGY   79   35 - 41   2017.7

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    DOI： 10.1016/j.archoralbio.2017.03.003

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  • Factors associated with mucosal dryness in multiple regions and skin: A web-based study in women Reviewed

    Kayoko Ito, Kiyoshi Takamatsu, Kaname Nohno, Aki Sugano, Saori Funayama, Kouji Katsura, Noboru Kaneko, Mariko Ogawa, Jukka H. Meurman, Makoto Inoue

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   43 ( 5 )   880 - 886   2017.5

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    DOI： 10.1111/jog.13290

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  • パパイン含有ゲル併用舌清掃による舌苔除去効果 Reviewed

    濃野 要, 山賀 孝之, 金子 昇, 宮崎 秀夫

    口腔衛生学会雑誌   66 ( 1 )   9 - 14   2016.1

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  • 歯周炎罹患歯肉組織におけるNeprilysin(Alzheimer病関連遺伝子)の発現

    根津 新, 久保田 健彦, 丸山 智, 水田 昌毅, 堀水 慎, 濃野 要, 保苅 崇大, 両角 俊哉, 朔 敬, 吉江 弘正

    日本歯周病学会会誌   57 ( 秋季特別 )   131 - 131   2015.8

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  • ホエイペプチド配合免疫調整流動食経口摂取が歯周炎患者における歯肉溝滲出液の炎症性サイトカインに与える影響 Reviewed

    久保田 健彦, 冨田 尊志, 濃野 要, 阿部 大輔, 清水 太郎, 杉田 典子, 金子 昇, 根津 新, 川島 昭浩, 坪井 洋, 佐々木 一, 吉江 弘正

    日本歯科保存学雑誌   58 ( 2 )   109 - 116   2015.4

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  • Effect of periodontal treatment on adipokines in type 2 diabetes. Reviewed International journal

    Ogawa H, Damrongrungruang T, Hori S, Nouno K, Minagawa K, Sato M, Miyazaki H

    World journal of diabetes   5 ( 6 )   924 - 931   2014.12

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    The association between adipokines and inflammatory periodontal diseases has been studied over the last two decades. This review was intended to explore the observation that periodontal therapy may lead to an improvement of adipokines in diabetic patients. In summary, substantial evidence suggests that diabetes is associated with increased prevalence, extent and severity of periodontitis. Numerous mechanisms have been elucidated to explain the impact of diabetes on the periodontium. However, current knowledge concerning the role of major adipokines indicates only some of their associations with the pathogenesis of periodontitis in type 2 diabetes. Conversely, treatment of periodontal disease and reduction of oral inflammation may have positive effects on the diabetic condition, although evidence for this remains somewhat equivocal.

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  • 日本人閉経後女性における腟症状の現状 Webアンケートの解析から Reviewed

    高松 潔, 伊藤 加代子, 小川 真里子, 濃野 要, 山田 亜紀, 船山 さおり

    日本女性医学学会雑誌   21 ( 1 )   36 - 41   2013.9

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  • 女性におけるドライシンドロームの有訴率に関するWeb調査 Reviewed

    伊藤 加代子, 高松 潔, 濃野 要, 山田 亜紀, 船山 さおり, 小川 真里子, 井上 誠

    日本女性医学学会雑誌   20 ( 3 )   399 - 405   2013.4

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  • Evaluation of the relationship between salivation ability and blood flow velocity in the submandibular gland using pulsed Doppler ultrasonography Reviewed

    Kouji Katsura, Kayoko Ito, Kaname Nohno, Saori Funayama, Mikiko Saito, Takafumi Hayashi

    ORAL RADIOLOGY   29 ( 1 )   13 - 18   2013.1

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  • Katsura K, Ito K, Nohno K, Funayama S, Saito M, Hayashi T. Evaluation of the relationship between salivation ability and blood flow velocity in the submandibular gland using pulsed Doppler ultrasonography Reviewed

    Katsura K, Ito K, Nohno K, Funayama S, Saito M, Hayashi T

    Oral Radiol   29 ( 1 )   13 - 18   2013.1

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  • Microbiological effect of essential oils in combination with subgingival ultrasonic instrumentation and mouth rinsing in chronic periodontitis patients Reviewed

    Toshiya Morozumi, Takehiko Kubota, Daisuke Abe, Taro Shimizu, Kaname Nohno, Hiromasa Yoshie

    International Journal of Dentistry   2013   146479   2013

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  • Serum Antibody to Porphyromonas gingivalis in Chronic Kidney Disease Reviewed

    M. Iwasaki, G. W. Taylor, M. C. Manz, N. Kaneko, S. Imai, A. Yoshihara, H. Miyazaki

    JOURNAL OF DENTAL RESEARCH   91 ( 9 )   828 - 833   2012.9

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  • Association Between Volatile Sulfur Compounds and Periodontal Disease Progression in Elderly Non-Smokers Reviewed

    Yuka Makino, Takayuki Yamaga, Akihiro Yoshihara, Kaname Nohno, Hideo Miyazaki

    JOURNAL OF PERIODONTOLOGY   83 ( 5 )   635 - 643   2012.5

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  • Tablets containing a cysteine protease, actinidine, reduce oral malodor: a crossover study Reviewed

    K. Nohno, T. Yamaga, N. Kaneko, H. Miyazaki

    JOURNAL OF BREATH RESEARCH   6 ( 1 )   2012.3

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    DOI： 10.1088/1752-7155/6/1/017107

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  • <b>Moistened Techniques Considered for Patientsʼ Comfort and Operatorsʼ Ease in Dental Treatment </b> Reviewed

    Ito Kayoko, Funayama Saori, Katsura Kouji, Kaneko Noboru, Nohno Kaname, Saito Mikiko, Yamada Aki, Sumida Yoshimi, Inoue Makoto

    IJOMS   11 ( 2 )   85 - 89   2012

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    <b>Aim</b>: In dental treatment, to remove an instrument, such as dental mirror or to remove a dental cotton roll inserted in the gingivobuccal fold, often brings the patient discomfort or pain. To prevent these uncomfortable conditions, dental instruments or dental cotton rolls are moistened based on an empirical basis. However, there has been no research done evaluating whether discomfort is reduced by these techniques. The purpose of this study was to evaluate the effects of moistened techniques on the patientsʼ discomfort and the operatorsʼ ease. <b>Materials and Methods</b>: Thirty eight subjects without hyposalivation were studied. Two procedures were implemented. One was that a dry or moistened dental mirror was removed after exclusion of the buccal mucosa. The other was removal of a dental cotton roll from the gingivobuccal fold after either moistening it or leaving it dry. The subjectsʼcomfort and the operatorsʼ treatment ease were evaluated on five point scales. <b>Results</b>: During these procedures, the subjectsʼ comfort was significantly increased by moistening of both the dental mirror and the cotton roll. The ease of performing both procedures was also significantly increased for operators in the moistened condition. In addition, there was a significant positive correlation between the subjectsʼ comfort and the operatorsʼ ease. <b>Conclusion</b>: When using dental instruments and removing cotton rolls, moistening increases both the subjectsʼ comfort and operatorsʼ treatment ease.

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  • 乳酸菌配合シュガーレスガムが歯周病患者唾液中の歯周病原細菌叢へ与える影響 Reviewed

    山口 人巳, 久保田 健彦, 濃野 要, 両角 俊哉, 飯山 真奈美, 川崎 健司, 吉江 弘正

    日本歯科保存学雑誌   54 ( 6 )   466 - 475   2011.12

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  • Influence of dental occlusion on physical fitness decline in a healthy Japanese elderly population Reviewed

    Naoko Okuyama, Takayuki Yamaga, Akihiro Yoshihara, Kaname Nohno, Yutaka Yoshitake, Yasuo Kimura, Mieko Shimada, Naoki Nakagawa, Mamoru Nishimuta, Masaharu Ohashi, Hideo Miyazaki

    ARCHIVES OF GERONTOLOGY AND GERIATRICS   52 ( 2 )   172 - 176   2011.3

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  • Fluoride Intake of Japanese Infants from Infant Milk Formula Reviewed

    K. Nohno, F. V. Zohoori, A. Maguire

    CARIES RESEARCH   45 ( 5 )   486 - 493   2011

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  • 揮発性硫黄化合物産生抑制におけるプロポリス含嗽剤14日間使用の効果 無作為化クロスオーバー試験による検討 Reviewed

    森田 眞司, 濃野 要, 山賀 孝之, 宮崎 秀夫

    口腔衛生学会雑誌   60 ( 1 )   17 - 22   2010.1

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  • Differential gene and protein expression of tissue inhibitors of metalloproteinases (TIMP)-3 and TIMP-4 in gingival tissues from drug induced gingival overgrowth Reviewed

    Naohiro Nakasone, Takehiko Kubota, Chika Hoshino, Kaname Nohno, Manami Itagaki, Taro Shimizu, Hiromasa Yoshie

    ARCHIVES OF ORAL BIOLOGY   54 ( 7 )   634 - 641   2009.7

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  • Proteome analysis of gelatin-bound salivary proteins in patients with primary Sjogren&apos;s Syndrome Identification of matrix metalloproteinase-9 Reviewed

    Kayoko Ito, Saori Funayama, Yasumasa Hitomi, Shuichi Nomura, Kouji Katsura, Mikiko Saito, Takefumi Hayashi, Noboru Kaneko, Kaname Nohno, Atsuko Igarashi

    CLINICA CHIMICA ACTA   403 ( 1-2 )   269 - 271   2009.5

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  • ワッテ法と吐唾法による唾液分泌量の比較 Reviewed

    船山 さおり, 伊藤 加代子, 濃野 要, 人見 康正, 宮崎 秀夫, 井上 誠, 五十嵐 敦子

    新潟歯学会雑誌   38 ( 2 )   95 - 101   2008.12

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    Other Link： http://search.jamas.or.jp/link/ui/2009113193

  • 内視鏡検査により上部消化管に重複癌が検出された顎口腔領域癌患者の臨床的検討 Reviewed

    山中 正文, 飯田 明彦, 藤田 一, 星名 秀行, 児玉 泰光, 小山 貴寛, 濃野 要, 高木 律男

    日本口腔科学会雑誌   57 ( 3 )   303 - 310   2008.7

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    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    DOI： 10.11277/stomatology1952.57.303

    CiNii Article

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  • Fluoride intake from food and liquid in Japanese children living in two areas with different fluoride concentrations in the water supply Reviewed

    K. Nohno, S. Sakuma, H. Koga, M. Nishimuta, M. Yagi, H. Miyazaki

    CARIES RESEARCH   40 ( 6 )   487 - 493   2006

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000095647

    Web of Science

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MISC

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Research Projects

  • Daily steps and mortality: a 30-year longitudinal study from age 70 to 100 years

    Grant number：24K14703

    2024.4 - 2028.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

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  • 嗅覚と唾液は自発性異常味覚の苦味を説明できるか？

    Grant number：24K13258

    2024.4 - 2027.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    船山 さおり, 伊藤 加代子, 任 智美, 濃野 要, 藤村 忍, 山崎 学, 井上 誠

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • Randomized controlled trial for effect of antimicrobial periodontal treatment on risk of cardiac infarction among diabetic patients

    Grant number：23K09478

    2023.4 - 2026.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • 医療人材不足のへき地における少人数で実践可能な地域包括ケアシステムモデルの構築

    Grant number：23K01871

    2023.4 - 2026.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    米澤 大輔, 濃野 要

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • Oral hypofunction in terms of nutritional intake and physical frailty in very older adults

    Grant number：22K10287

    2022.4 - 2025.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • エクオールは口腔乾燥症，味覚障害，舌痛症の新たな治療法となりうるか？

    Grant number：22K10310

    2022.4 - 2025.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    伊藤 加代子, 井上 誠, 高松 潔, 船山 さおり, 本川 佳子, 泉 健次, 濃野 要

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Elucidation of connection between oral microbiome and halitosis using metagenomic analysis

    Grant number：22K10338

    2022.4 - 2025.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • 歯科口腔保健の推進に資するう蝕予防のための手法に関する研究

    Grant number：202122067A

    2021.4 - 2022.3

    System name：令和3年度厚生労働行政推進調査事業費補助金（地域医療基盤開発推進研究事業）

    Awarding organization：厚生労働省

    相田 潤, 研究分担者, 晴佐久 悟, 濃野 要, 竹内 研時, 磯﨑 篤則, 荒川 浩久, 石塚 洋一, 古田 美智子, 松山 祐輔, 廣瀬 晃子

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  • 糖尿病患者の脳梗塞リスクに対する抗菌的歯周治療の有用性に関するランダム化比較試験

    Grant number：20K10291

    2020.4 - 2023.3

    System name：科学研究費助成事業 基盤研究(C)

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    小川 祐司, 山田 貴穂, 濃野 要, 皆川 久美子

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    Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）

    研究課題「糖尿病患者の脳梗塞リスクに対する抗菌的歯周治療の有用性に対するランダム化比較試験」は、令和2年8月に新潟大学倫理審査委員会にて倫理審査承認（2020-0126）を得て開始した。本研究はアディポサイトカイン、とくにアディポネクチンの濃度変化に着目して、血管障害の改善に対する抗菌的歯周治療の効果を検証し、脳梗塞リスクへの抗菌的歯周治療の有用性に関するエビデンスを構築することを目的としている。
    令和3年度は、新たに25名の研究対象者のリクルート（総数50目標）を計画したが、令和4年3月末時点で研究参加者総数は30名で、うち21名が研究完了となっている。新型コロナウイルス感染拡大による歯科受診控えはだいぶ少なくなったが、研究参加期間が長いこと、すでに歯科受診をしているなどの理由で参加に同意を得られない場合が多く、参加者確保に時間を要している。すでに内科医と相談し、令和4年度にも対象者のスクリーニングを継続する予定である。また状況によっては、科研研究そのものの延長も視野に入れている。
    なお、研究参加者への口腔内処置は、新潟大学医歯学総合病院の感染対策マニュアルに準じて適切な感染対策下で実施しており、問題は発生していない。また、抗菌剤の局所投与についても、日本歯周病学会の抗菌療法診療ガイドラインに準じて適切な薬剤を適切な量と期間使用を遵守しており、必要最小限度の投与を行っている。薬剤耐性菌等の発生はない。
    令和4年度も万全な感染対策の下、対象者に対して研究計画の目的、内容ならびに個人情報の保護等について書面にて十分な説明を行い、さらなる研究参加者の確保（新規に20名）を目指す。

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  • 自発性異常味覚の苦味の正体にせまる

    Grant number：20K10264

    2020.4 - 2023.3

    System name：科学研究費助成事業 基盤研究(C)

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    船山 さおり, 井上 誠, 山崎 学, 藤村 忍, 伊藤 加代子, 濃野 要

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    本年度は，主に自発性異常味覚患者のデータ収集に努めた．また，味覚センサーの測定条件の検証を行った昨年度の結果をもとに，実際のデータ測定を進めている．今年度は，昨年はコロナ禍で他施設の利用ができずに不可能であった，味覚センサーの測定も進められた．苦味の詳細は，唾液の成分分析を行った後，考察を行えるようになる．しかしながら，唾液の成分分析は資金繰りの都合上，全データ収集後に行う予定であり，データ収集が遅れているため，いまだ行えていないのが現状である．

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  • 口腔細菌叢のメタゲノム解析によるドライマウスの病態解明

    Grant number：19K10421

    2019.4 - 2022.3

    System name：科学研究費助成事業 基盤研究(C)

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    金子 昇, 濃野 要

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    高齢者の増加に伴いドライマウス患者が増加している。唾液の減少は口腔内細菌叢の組成バランスを崩し、この菌叢の変化はドライマウスの病態に影響を及ぼしていると考えられる。
    新潟大学医歯学総合病院 予防歯科の外来患者を対象として、口腔細菌叢とドライマウスに伴う口腔症状との関連性について検討を行った。
    通常、口腔内細菌の検体採取としては、唾液採取や擦過サンプルを使用することが多い。ただ、今回はドライマウス患者から検体を採取するため、唾液を献体として使用することが難しい。また、ドライマウス患者は粘膜が過敏になっている方も多く、粘膜を擦過することは負担を強いることになりうる。さらに擦過サンプルは部位によって菌叢が大きく変化することが予想されることから、今回は一定時間洗口した後に吐き出してもらう洗口サンプルを使用した。
    新型コロナウイルス流行の影響により、研究の進行が遅れ気味で、現在も対象者の募集を継続中であるが、現在まで集まった洗口サンプルのうち、特に口腔乾燥と舌痛の訴えのある患者1名で、他の対象者とは異なる特徴的な菌叢が認められた。すなわち、通常、Streptococcusの割合は30～40%の範囲に収まる患者が多い中で、この患者はStreptococcusの割合が57%を占めており、そのうち、anginosus groupの菌数が特に高い値を示していた。anginosus groupは、日和見的に口腔内や深部臓器などで化膿性疾患を引き起こす細菌である。引き続き、例数を増やして口腔乾燥やそれに伴う口腔内の疼痛を訴える方の細菌叢の特徴について検討していく予定である。

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  • Deriving a regression model for saliva flow rate in the elderly : a longitudinal study.

    Grant number：16K11884

    2016.4 - 2020.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Nohno Kaname

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

    The purpose of this study was to examine the factors related to the decrease in salivary flow rates of the elderly in 10-year longitudinal study. We measured the stimulated salivary flow rates (SSFR) and unstimulated salivary flow rate (USFR), blood tests, stress test, and lifestyle habits when the subjects were 80 and 90 years old. We found that a mean decrease of 20% of SSFR and 10% of USFR in 10 years. As a results, female gender, reduced renal function, and β3 adrenergic receptor genotype were suggested as risk factors for decrease in salivary flow rates.

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  • Survey of the prevalence of dry syndrome and its related factors

    Grant number：25463238

    2013.4 - 2016.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Ito Kayoko, TAKAMATSU kiyoshi, FUNAYAMA saori, NOHNO kaname

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    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    In xerostomia clinic, 51.3% patients had dryness of eyes, 35.5% patients had dryness of nose, 17.1% patients had dryness of skin, and 30.0% patients had dryness of vagina. In gynecological patient, 42.1% patients had dryness of the nose, 48.4% patients had dryness of mouth,and 25.3 patients had dryness of vagina. Only dryness of mouth was related to chromogranin A, which is a stress marker.The treatment which was including chinese herbal medicine and counseling was performed to the patients who had complained of all regions of dryness. The dryness of the eyes and nose were improved by these treatments. It was suggested that the treatment for xerostomia improved dryness of another regions.

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  • Elevated expression of Alzheimer disease related genes in periodontiti-affected gingival tissues

    Grant number：24593119

    2012.4 - 2016.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Kubota Takehiko, MARIYAMA SATOSHI, NOUNO KANAME

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    Grant amount：\5330000 （ Direct Cost: \4100000 、 Indirect Cost：\1230000 ）

    We have first reported that the significantly elevated expression of Amyloid beta (A4) precursor protein (APP) transcript levels in human periodontitis-affected gingival tissues. It was also identified that the APP-expressing cells in inflamed gingival tissues were mainly macrophages (Archs Oral Biol 2014). Secondary, significantly upregulated genes including MD-2, CD14, IL-1beta, IL-8 and CXCL-9, which belongs to toll-like receptor (TLR) signaling pathway were also found in periodontitis-affected gingival tissues. It was reported and published in Opn J Stomatol 2014.

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  • Are salivary stress-related biomarkers available as indicators of xerostomia?

    Grant number：24792350

    2012.4 - 2016.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Research category：Grant-in-Aid for Young Scientists (B)

    Awarding organization：Japan Society for the Promotion of Science

    NOHNO Kaname

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    Grant amount：\3380000 （ Direct Cost: \2600000 、 Indirect Cost：\780000 ）

    Psychological stress causes a reduction of salivary flow, it is necessary to assess the stress on diagnosis of xerostomia. There are stress-related biomarkers in saliva. The purpose of this study was to evaluate a correlation between the reduction of salivary flow and salivary stress-related biomarkers. In conclusion, we found a possibility of correlation between stimulated salivary flow and salivary IgA. However, we didn’t find statistically significant correlations of amount nor change ratios between salivary flow and stress-related biomarkers.

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  • Pathological roles of tissue inhibitors of metalloproteinases in the tissues of drug-induced fibrous gingival over growth.

    Grant number：21592622

    2009 - 2011

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    KUBOTA Takehiko, NAKASONE Naohiro, MARUYAMA Satoshi, NOUNO Kaname

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    We have reported the 1^<st> report "Gene expression and immunohistochemical protein localization of TIMP-3 and TIMP-in gingival overgrowth and periodontitis-affected gingival tissues" Archs Oral Biology(2009). Then I have received the Academic Senior Investigator's Award for this series of studies in 2009 from Japanese Society of Conservative Dentistry(Review 2010)。The 2^<nd> and 3^<rd> reports :"Microarray and data-mining analyses for specific gene expression in drug-induced gingival overgrowth tissues. Archs Oral Biology(2011)", and "Altered gene expression pattern and specific biological pathways in periodontitis-affected gingival tissues." J Periodont Res(2011) have published in international scientific peer review journals.

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  • Herbal medicine changes tongue coatings and volatile sulphur compounds

    Grant number：20791636

    2008 - 2009

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Research category：Grant-in-Aid for Young Scientists (B)

    Awarding organization：Japan Society for the Promotion of Science

    NOHNO Kaname

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    Grant amount：\3250000 （ Direct Cost: \2500000 、 Indirect Cost：\750000 ）

    Oral malodor is caused mainly by volatile sulfur compounds (VSC). It is well known that a tongue coating (TC) is one of the major sources of VSC. Therefore, it is important to reduce TC for preventing bad breath. The purpose of this study was to measure VSC, amount of TC and volumes of saliva flow that is relevant to bad breath after taking the herbal medicine. As a result, VSC and TC were declined and volume of saliva flow was increased for each subject after 8 weeks taking; however, there were no statistical significances.

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  • Effects of plant-derived protease on removing tongue coatings and reducing volatile sulphur compounds in oral air

    Grant number：18390565

    2006 - 2008

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

    MIYAZAKI Hideo, YAMAGA Takayuki, KANEKO Noboru, NOHNO Kaname

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    Grant amount：\8180000 （ Direct Cost: \6800000 、 Indirect Cost：\1380000 ）

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  • 日本の小児におけるフッ化物の1日総摂取量に関する研究

    2001 - 2004

    System name：保健医療分野における基礎研究推進事業

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    Grant type：Competitive

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  • Satudy on Total Fluoride Intake a day in Japanese Children

    2001 - 2004

    System name：Basic Research Promotion Service for Health and Medical Field

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    Grant type：Competitive

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Teaching Experience

  • 歯科衛生士臨床実習I

    2023
    Institution name：新潟大学

  • 歯科衛生士臨床実習II

    2023
    Institution name：新潟大学

  • 歯科衛生士臨床実習III

    2022
    Institution name：新潟大学

  • 障害者福祉論II

    2022
    Institution name：新潟大学

  • 児童福祉論II

    2022
    Institution name：新潟大学

  • 社会福祉原論II

    2022
    Institution name：新潟大学

  • 歯科衛生学II

    2022
    Institution name：新潟大学

  • 歯学スタディ・スキルズ

    2022
    Institution name：新潟大学

  • 高齢者福祉論II

    2022
    Institution name：新潟大学

  • ネットワーク型先端歯学研究

    2022
    Institution name：新潟大学

  • 口腔保健福祉学研究ベーシックコース

    2022
    Institution name：新潟大学

  • 臨床歯科学III

    2021
    Institution name：新潟大学

  • 臨床歯科学I

    2021
    Institution name：新潟大学

  • 口腔の科学

    2021
    Institution name：新潟大学

  • 臨床歯科学II

    2021
    Institution name：新潟大学

  • 臨床歯科学IV

    2021
    Institution name：新潟大学

  • 生命医療科学総論

    2021
    Institution name：新潟大学

  • 実践医学統計演習IIA

    2021
    Institution name：新潟大学

  • 一般口腔保健管理学II

    2021
    Institution name：新潟大学

  • 口腔保健管理学特論

    2021
    Institution name：新潟大学

  • 健康福祉学入門

    2021
    Institution name：新潟大学

  • 実践統計学べ－シックコース

    2021
    Institution name：新潟大学

  • 口腔保健福祉学研究論I

    2021
    Institution name：新潟大学

  • 予防歯科学演習IB

    2021
    Institution name：新潟大学

  • 実践医学統計演習IA

    2021
    Institution name：新潟大学

  • 予防歯科学演習IA

    2021
    Institution name：新潟大学

  • 予防歯科学演習IIA

    2021
    Institution name：新潟大学

  • 予防歯科学演習IIB

    2021
    Institution name：新潟大学

  • 歯学研究演習

    2020
    Institution name：新潟大学

  • 包括社会歯科学

    2020
    Institution name：新潟大学

  • 生涯にわたる歯と咬合

    2019
    Institution name：新潟大学

  • 社会調査法

    2019
    Institution name：新潟大学

  • 早期臨床実習ⅠB

    2019
    Institution name：新潟大学

  • PBL入門

    2018
    Institution name：新潟大学

  • 医療統計学

    2017
    Institution name：新潟大学

  • 早期臨床実習Ⅰ

    2017
    -
    2020
    Institution name：新潟大学

  • 予防歯科学

    2007
    Institution name：新潟大学

  • 予防歯科学実習

    2007
    -
    2020
    Institution name：新潟大学

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