Faculty Profiles - BABA Hiroshsi

Papers - BABA Hiroshsi

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SPINAL-CORD POTENTIAL RECORDINGS FROM THE EXTRADURAL SPACE DURING SCOLIOSIS SURGERY Reviewed

H FUJIOKA, K SHIMOJI, M TOMITA, S DENDA, T TAKADA, T HOMMA, S UCHIYAMA, H TAKAHASHI, T TOBITA, H BABA

BRITISH JOURNAL OF ANAESTHESIA 73 ( 3 ) 350 - 356 1994.9

Language：English Publishing type：Research paper (scientific journal) Publisher：PROF SCI PUBL

For monitoring spinal cord functions during corrective surgery of scoliosis, we have recorded percutaneously from the posterior extradural space at the C5-7 levels the ascending conducted spinal cord potentials (ASCP) in response to extradural stimulation of the cauda equina in 134 patients. The ASCP consists of three spike-like components (C1, C2 and C3) followed by slow components. The extradurally recorded ASCP were not affected by anaesthetic agents. There were no significant differential effects of spinal distractions on each of the three spike potentials. There were no postoperative neurological abnormalities in patients whose ASCP showed no changes, amplitude increases, amplitude decreases of less than 50% or latency increases (> 0.2 ms) during spinal manipulations (no false negatives, but some false positives). Five patients who suffered postoperative neurological damage exhibited more than 50% changes in amplitude of the ASCP during surgery. All these neurological sequelae occurred in the first 80 patients. In the last 54 patients, in whom the distraction forces on the spine were controlled rapidly by observation of the amplitude changes in ASCP, there were no postoperative neurological abnormalities, except for one patient in whom an accidental spinal cord injury was produced by a hook. The results suggest that the distraction force on the spine must be reduced immediately when the amplitudes of the ASCP decrease by more than 50% of control values with or without latency increases.

File： Fujioka(BJA,1994).pdf

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SYNAPTIC RESPONSES OF SUBSTANTIA-GELATINOSA NEURONS TO DORSAL COLUMN STIMULATION IN RAT SPINAL-CORD IN-VITRO Reviewed

H BABA, M YOSHIMURA, S NISHI, K SHIMOJI

JOURNAL OF PHYSIOLOGY-LONDON 478 ( 1 ) 87 - 99 1994.7

Language：English Publishing type：Research paper (scientific journal) Publisher：CAMBRIDGE UNIV PRESS

1. To study the mechanism of dorsal column stimulation-induced depression of nociceptive transmission in the spinal cord, synaptic responses evoked in dorsal horn neurones by dorsal column and dorsal root stimulations were examined in a horizontal spinal cord slice of the adult rat. Intracellular recordings were made from substantia gelatinosa (SG) neurones.
2. All SG neurones examined received monosynaptic inputs and/or polysynaptic inputs from both dorsal column and dorsal root. AS fibres were probably responsible for the synaptic responses. The responses evoked by dorsal column stimulation were similar to those evoked by primary afferent AS fibre stimulation.
3. Monosynaptic excitatory postsynaptic potentials (EPSPs) evoked by dorsal column AS fibres were depressed by 8-cyano-7-nitroquinoxaline-2,3-dione, suggesting that these fibres released L-glutamate or a related amino acid as a transmitter.
4. In 38 of 101 SG neurones, dorsal column stimulation evoked an initial EPSP followed by fast and/or slow inhibitory postsynaptic potentials (IPSPs). These IPSPs reversed polarity at a membrane potential of -73 +/- 2 mV. The fast IPSPs observed in 16 of the SG neurones (42 %) that received inhibitory inputs were depressed by strychnine, while the slow IPSPs observed in 22 SG neurones were depressed by bicuculline. In a few cells, a long-lasting slow IPSP with a much slower time course was detected; this IPSP was insensitive to strychnine and bicuculline, and reversed polarity at a membrane potential near -90 mV.
5. Repetitive stimulation of the dorsal column depressed the amplitude of monosynaptic EPSPs evoked by dorsal root stimulation.
6. The responses of SG neurones to dorsal column stimulation had configurations and durations similar to responses to dorsal root stimulation, and may be mediated largely by the same AS fibres. However, a C fibre-mediated response could not be detected in SG neurones from dorsal column stimulation, although dorsal root stimulation could evoke C fibre-mediated monosynaptic EPSPs in 18 of 88 SG neurones (20 %).
7. These observations suggest that XG neurones receive abundant A delta but not C fibre inputs from the dorsal column and that dorsal column stimulation inhibits primary afferent transmission in the spinal cord both by reducing transmitter release from primary AS fibres and by hyperpolarizing SQ neurones.

File： jphysiol00345-0089.pdf

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ERBS POINT STIMULATION PRODUCES SLOW POSITIVE POTENTIALS IN THE HUMAN LUMBAR SPINAL-CORD Reviewed

K SHIMOJI, M TOMITA, T TOBITA, H BABA, T TAKADA, S FUKUDA, S AIDA, N FUJIWARA

JOURNAL OF CLINICAL NEUROPHYSIOLOGY 11 ( 3 ) 365 - 374 1994.5

Language：English Publishing type：Research paper (scientific journal) Publisher：LIPPINCOTT-RAVEN PUBL

Evoked spinal cord potentials (SCPs) were recorded from the posterior epidural space (PES) at the cervical and lumbrosacral enlargements in response to electrical stimulation of the brachial plexus at Erb's point in 17 chronic pain patients. Erb's point stimulation produced slow positive potentials (heterosegmental slow positive potentials, HSPs) in the PES at the lumbrosacral enlargement in all 13 subjects without spinal cord lesions but not in 4 subjects with spinal cord lesions. The HSP1 with a central peak latency of 21 +/- 2 ms (mean +/- SE) was recorded at the stimulus intensity up to two to three times the threshold strength (T) of the initially positive spike (P1) of the segmental SCP, which was simultaneously recorded from the PES at the cervical enlargement At the stimulus intensity of more than 3T, another slow positive potential (HSP2) with central peak latency of 71 +/- 6 ms was recorded. These slow positive potentials (HSP1 and HSP2) might be produced by a feedback loop via supraspinal structures, presumably primary afferent depolarizations, in comparison to the HSPs of our previous studies in the rat. Slow negative potentials were sometimes noted before (5 of 13) and/or after (2 of 13) the HSP1. These slow negative potentials probably reflect the activities of dorsal horn neurons producing the HSP1 and HSP2, respectively, also elicited by a feedback loop via supraspinal structures.

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ELECTROPHYSIOLOGICAL PHENOMENA RECORDED FROM SPINAL-CORD SLICE PREPARATION IN THE ADULT-RAT Reviewed

H BABA, Y SATO, K SHIMOJI, M YOSHIMURA, H HIGASHI

HANDBOOK OF SPINAL CORD MONITORING 393 - 397 1994

HUMAN SPINAL-CORD POTENTIALS RECORDED FROM THE EPIDURAL SPACE Reviewed

K SHIMOJI, M TOMITA, T HOKARI, S DENDA, T TOBITA, H BABA, S FUKUDA

HANDBOOK OF SPINAL CORD MONITORING 21 - 36 1994

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