研究者詳細 - 小野寺　理

論文 - 小野寺　理

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Clinicopathologic features of two unrelated autopsied patients with Charcot-Marie-Tooth disease carrying MFN2 gene mutation. 国際誌

Hideki Hayashi, Rie Saito, Hidetomo Tanaka, Norikazu Hara, Shin Koide, Yosuke Yonemochi, Tetsuo Ozawa, Mariko Hokari, Yasuko Toyoshima, Akinori Miyashita, Osamu Onodera, Kouichirou Okamoto, Takeshi Ikeuchi, Takashi Nakajima, Akiyoshi Kakita

Acta neuropathologica communications 11 ( 1 ) 207 - 207 2023年12月

Missense Variants in COL4A1/2 Are Associated with Cerebral Aneurysms: A Case Report and <span aria-describedby="tippy-31">Literature Review

Masahiro Uemura, Natsuki Tanaka, Shoichiro Ando, Takehiko Yanagihara, Osamu Onodera

Neurology International 2023年12月

Neuroprotective effects of oral metformin before stroke on cerebral small-vessel disease. 国際誌

Natsuki Akiyama, Takayuki Yamashiro, Itaru Ninomiya, Masahiro Uemura, Yorito Hattori, Masafumi Ihara, Osamu Onodera, Masato Kanazawa

Journal of the neurological sciences 456 122812 - 122812 2023年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Metformin (MET) treatment prior to stroke might have neuroprotective effects other than hypoglycemic effects. This study evaluated whether MET treatment prior to stroke is associated with neurological severity and functional outcome in patients with stroke who were not indicated for endovascular treatment and whether the effects of MET differ for each ischemic stroke subtype. METHODS: We investigated 160 type 2 diabetes mellitus patients with ischemic stroke without endovascular treatment who were taking some oral antidiabetic agents prior to stroke in two tertiary hospitals. Lower neurological severity was defined as a National Institutes of Health Stroke Scale score of 3 or lower on admission, and favorable functional outcome was defined as a modified Rankin Scale score = 0-2 at discharge. We analyzed the effects of MET on the neurological severity and functional outcome in each ischemic stroke subtype on logistic regression analysis with adjustments for multiple confounding factors. RESULTS: MET treatment prior to stroke was associated with lower stroke severity and favorable functional outcome. In the stroke subtypes, MET use affected both neurological severity (P = 0.037) and functional outcome (P = 0.041) in only patients with small-vessel disease (SVD). CONCLUSIONS: MET may be useful to improve the outcome of patients with SVD.

DOI： 10.1016/j.jns.2023.122812

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Marked laterality of olivopontocerebellar pathology in an autopsied patient with MSA: Implications for degeneration and α-synuclein propagation. 国際誌

Misato Ozawa, Rie Saito, Takuya Konno, Reiji Koide, Shigeru Fujimoto, Osamu Onodera, Akiyoshi Kakita

Journal of neurology, neurosurgery, and psychiatry 2023年11月

小脳出血で失語症を呈した一例

木下悠紀子, 畠山公大, 大槻美佳, 石黒敬信, 佐治越爾, 金澤雅人, 小野寺理

臨床神経学 63 ( 11 ) 772 - 772 2023年11月

A case report of reversible cerebral vasoconstriction syndrome with thunderclap headache significantly exacerbated in the supine position and alleviated in the standing position. 国際誌

Genri Toyama, Shintaro Tsuboguchi, Kazuya Igarashi, Etsuji Saji, Takuya Konno, Osamu Onodera

BMC neurology 23 ( 1 ) 348 - 348 2023年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by sudden onset thunderclap headache and multiple segmental reversible cerebral vasoconstrictions that improve within 3 months. The postpartum period is a well-known precipitating factor for the onset of RCVS. Cerebral venous thrombosis (CVT) causes thunderclap headaches in the postpartum period. While headache in CVT is sometimes exacerbated in the supine position, the severity of the headache in RCVS is usually independent of body position. In this study, we report a case of RCVS with thunderclap headache exacerbated in the supine position, and headache attacks that resolved quickly in the standing position during the postpartum period. CASE PRESENTATION: A 33-year-old woman presented with a sudden increase in blood pressure and thunderclap headache on the fifth postpartum day (day 1: the first sick day). The headache was severe and pulsatile, with onset in the supine position in bed, and peaked at approximately 10 s. It was accompanied by nausea and chills but there were no scintillating scotomas or ophthalmic symptoms. The headache resolved in the standing or sitting position but was exacerbated and became unbearable within a few seconds when the patient was in the supine position. Therefore, she was unable to lie supine at night. Computed tomography angiography (CTA) of the head on day 2 and magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) on day 3 showed no abnormalities. However, considering the possibility of RCVS, verapamil was initiated on day 3. The headache resolved the following day. MRA of the head on day 10 revealed diffuse and segmental stenoses in the bilateral middle and posterior cerebral arteries and basilar artery. Therefore, the patient was diagnosed with RCVS. The headache gradually resolved and disappeared completely on day 42. Cerebral vasoconstriction was also improved on MRA on day 43. CONCLUSIONS: This postpartum RCVS case was notable for the exacerbation of headaches in the supine position. For the diagnosis of thunderclap headache in the postpartum period, RCVS should be considered in addition to CVT when the patient presents with a headache that is exacerbated in the supine position.

DOI： 10.1186/s12883-023-03381-6

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アルツハイマー連続体における脳脊髄液αシヌクレインの臨床的有用性の検討

五十嵐一也, 春日健作, 月江珠緒, 菊地正隆, 宮下哲典, 小野寺理, 岩坪威, 池内健, Japanese Alzheimer's Disease Neuroimaging Initiative

Dementia Japan 37 ( 4 ) 687 - 687 2023年10月

若年性認知症の初診時臨床的特徴と脳脊髄液バイオマーカーの比較

大滝悠莉, 春日健作, 月江珠緒, 宮下哲典, 小野寺理, 池内健

Dementia Japan 37 ( 4 ) 684 - 684 2023年10月

脳アミロイドアンギオパチー関連炎症における脳脊髄液バイオマーカー

徳武孝允, 春日健作, 月江珠緒, 石黒敬信, 五十嵐一也, 小野寺理, 池内健

Dementia Japan 37 ( 4 ) 664 - 664 2023年10月

進行性核上性麻痺の脳脊髄液バイオマーカーによるAT(N)分類と臨床像

石黒敬信, 春日健作, 渡邉緑, 木下悠紀子, 月江珠緒, 小野寺理, 池内健

Dementia Japan 37 ( 4 ) 662 - 662 2023年10月

脳脊髄液アミロイドβ(Aβ)38の臨床的意義の検討

月江珠緒, 春日健作, 菊地正隆, 五十嵐一也, 大滝悠莉, 石黒敬信, 宮下哲典, 小野寺理, 岩坪威, 池内健, J-ADNI

Dementia Japan 37 ( 4 ) 658 - 658 2023年10月

リアルワールドにおける血漿バイオマーカーの有用性の検討

春日健作, 月江珠緒, 五十嵐一也, 石黒敬信, 宮下哲典, 小野寺理, 池内健

Dementia Japan 37 ( 4 ) 658 - 658 2023年10月

TDP-43は運動回路の変性を誘導するために異なって伝播する(TDP-43 differentially propagates to induce degeneration in the motor circuit)

坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 佐藤時春, 小山哲秀, 森秀樹, 小池佑佳, 小野寺理, 上野将紀

Dementia Japan 37 ( 4 ) 680 - 680 2023年10月

The Multifaceted Regulation of TDP-43 Condensates at the Intersection of Physiology and Pathology: Implications for Neurodegenerative Diseases

Akihiro Sugai, Takuma Yamagishi, Shingo Koide, Osamu Onodera

Phase Separation in Living Cells 253 - 270 2023年9月

発作性の神経症状を繰り返し、多発する微小出血像を認めた硬膜移植歴を有する39歳男性例

畠山祐樹, 坪口晋太朗, 石黒敬信, 佐治越爾, 畠山公大, 島田斉, 金澤雅人, 小野寺理

臨床神経学 63 ( 9 ) 603 - 603 2023年9月

SCA6の浸透性に関する研究(Study of penetrance of SCA6)

Hatano Yuya, Ishihara Tomohiko, Hirokawa Sachiko, Onodera Osamu

臨床神経学 63 ( Suppl. ) S335 - S335 2023年9月

脳梗塞発症前のメトホルミン内服による脳小血管病に対する神経保護効果

秋山夏葵, 二宮格, 山城貴之, 上村昌寛, 服部頼都, 猪原匡史, 小野寺理, 金澤雅人

臨床神経学 63 ( Suppl. ) S310 - S310 2023年9月

発作性の神経症状を繰り返し、多発する微小出血像を認めた硬膜移植歴を有する39歳男性例

畠山祐樹, 坪口晋太朗, 石黒敬信, 佐治越爾, 畠山公大, 島田斉, 金澤雅人, 小野寺理

臨床神経学 63 ( 9 ) 603 - 603 2023年9月

新潟県,脊髄小脳変性疫学調査-臨床調査個人票による調査

小出眞悟, 本郷祥子, 秋山夏葵, 中村航世, 小野寺理

臨床神経学 63 ( Suppl. ) S297 - S297 2023年9月

【神経変性疾患の眼球運動異常】脊髄小脳変性症の眼球運動の特徴や異常

小出眞悟, 石原智彦, 小野寺理

神経眼科 40 ( 3 ) 222 - 228 2023年9月

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