Faculty Profiles - TANUMA Junichi

Papers - TANUMA Junichi

Division display 21 - 40 of about 105 ／ All the affair displays >>

同種死細胞により誘導される口腔扁平上皮癌細胞の活性化メカニズム(Dead cancer cell-induced activation mechanisms of oral squamous cell carcinoma cells)

山崎学, 阿部達也, 丸山智, 田沼順一

日本癌学会総会記事 82回 233 - 233 2023.9

頭頸部扁平上皮癌における特異的選択的スプライシングの探索データベース解析とロングリード-ケンシング(Alternative splicing in head and neck squamous cell carcinoma: public database exploration and long-read sequencing)

阿部達也, 凌一葦, 奥田修二郎, 山崎学, 丸山智, 田沼順一

日本癌学会総会記事 82回 1083 - 1083 2023.9

Solitary central osteoma of the mandible with unusual clinicoradiological presentations: A case report and literature review Reviewed

Nyein Nyein Chan, Manabu Yamazaki, Hidenobu Sakuma, Takafumi Hayashi, Tadaharu Kobayashi, Jun‐ichi Tanuma

Oral Science International ( 20 ) 132 - 138 2023.7

Masticatory muscle tendon-aponeurosis hyperplasia that was initially misdiagnosed for polymyositis: a case report and review of the literature Reviewed

Wataru Katagiri, Daisuke Saito, Satoshi Maruyama, Makiko Ike, Hideyoshi Nisiyama, Takafumi Hayashi, Jun-ichi Tanuma, Tadaharu Kobayashi

Maxillofacial Plastic and Reconstructive Surgery 45 ( 18 ) 2023.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

Masticatory muscle tendon-aponeurosis hyperplasia (MMTAH) is a relatively newly identified clinical condition that manifests as trismus with a square-shaped mandible. Herein, we report a case of MMATH that was initially misdiagnosed for polymyositis due to trismus and simultaneous lower limb pain, with literature review.

Case presentation

A 30-year-old woman had a history of lower limb pain after exertion for 2 years. Initial physical examination had been performed at the Department of General Medicine in our hospital. There was also redness in the hands and fingers. Although polymyositis was suspected, it was denied. The patient visited our department for right maxillary wisdom tooth extraction.

Clinical examination revealed that the patient had a square-shaped mandible. The maximal mouth opening was 22 mm. There was no temporomandibular joint pain at the time of opening. Furthermore, there was awareness of clenching while working. Panoramic radiography revealed developed square mandibular angles with flattened condyles. Computed tomography showed enlarged masseter muscles with high-density areas around the anterior and lateral fascia. Magnetic resonance imaging also showed thickened tendons and aponeuroses on the anterior surface and inside bilateral masseter muscles. Finally, the patient was diagnosed with MMTAH. Bilateral aponeurectomy of the masseter muscles with coronoidectomy and masseter muscle myotomy was performed under general anesthesia. The maximum opening during surgery was 48 mm. Mouth opening training was started on day 3 after surgery. Histopathological examination of the surgical specimen showed that the muscle fibers were enlarged to 60 μm. Immunohistochemistry testing for calcineurin, which was associated with muscle hypertrophy due to overload in some case reports, showed positive results. Twelve months after surgery, the mouth self-opening and forced opening were over 35 mm and 44 mm, respectively.

Conclusions

Herein, we report a case of MMATH. Lower limb pain due to prolonged standing at work and overload due to clenching were considered risk factors for symptoms onset of MMATH.

File： Masticatory.pdf

DOI： 10.1186/s40902-023-00386-6

researchmap

Other Link： https://link.springer.com/article/10.1186/s40902-023-00386-6/fulltext.html

Cholesterol Is a Regulator of CAV1 Localization and Cell Migration in Oral Squamous Cell Carcinoma Invited Reviewed

Nyein Nyein Chan, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Kenta Haga, Masami Kawaharada, Kenji Izumi, Tadaharu Kobayashi, Jun-ichi Tanuma

International Journal of Molecular Sciences 24 ( 7 ) 6035 2023.3

唾液腺多形腺腫由来細胞は低酸素環境下にてCD73による増殖及び遊走能を亢進する

丸山智, 山崎学, 阿部達也, Chan Nyein Nyein, 田沼順一

日本病理学会会誌 112 ( 1 ) 292 - 292 2023.3

口腔扁平上皮癌におけるladinin-1と細胞極性・上皮性格制御

阿部達也, 山崎学, 丸山智, Chan Nyein Nyein, 田沼順一

日本病理学会会誌 112 ( 1 ) 289 - 289 2023.3

頭頸部癌特異的スプライシングイベントの探索

阿部達也, 山崎学, 丸山智, Chan Nyein Nyein, 田沼順一

日本病理学会会誌 112 ( 1 ) 291 - 291 2023.3

Liquid‐based cytology for differentiating two cases of pemphigus vulgaris from oral squamous cell carcinoma Reviewed International journal

Maruyama S, Yamazaki M, Abé T, Kato Y, Kano H, Sumita Y, Tomihara K, Tanuma J

Diagnostic Cytopathology 51 ( 5 ) 1 - 6 2023.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Pemphigus vulgaris (PV) is a rare autoimmune disease characterized by blisters on the skin and mucous membrane. Since it often appears in the oral mucosa first, it may be diagnosed by oral mucosal cytology. Although the cytologic finding is characterized by acantholytic cells, that is, Tzanck cells, it is important to distinguish PV from neoplastic lesions of the oral mucosal epithelium, including differentiation from atypical parabasal/basal cells, which appear in squamous cell carcinoma (SCC). In this study, we examined the cellular findings in two cases of PV and a case of well-differentiated SCC with loss of epithelial cell cohesion. The samples were prepared using liquid-based cytology, which showed small round-shaped and deeply stained atypical, orangeophilic keratinocytes not only in SCC but also in PV, which made differentiation between the two difficult. However, Tzanck cells found in PV differ from the deep atypical parabasal/basal cells of SCC, suggesting that the cell outline is indistinct and small protrusions and brush-like structures are observed. This feature of Tzanck cells may be useful in cytological judgment.

File： Diagnostic Cytopathology - 2023 - Maruyama - Liquid%E2%80%90based cytology for differentiating two cases of pemphigus vulgaris from.pdf

DOI： 10.1002/dc.25117

PubMed

researchmap

口底部に生じた異所性胃腸管嚢胞の1例

齋藤直朗, 丸山智, 加藤祐介, 竹内涼子, 田沼順一, 小林正治

日本口腔外科学会雑誌 69 ( 1 ) 27 - 31 2023.1

Language：Japanese Publisher：(公社)日本口腔外科学会

4歳5ヵ月女児。既往として出生前診断で指摘されていた口底部の嚢胞様病変に対し、生後3日に開窓術が施行され、病理組織学的に類表皮嚢胞と診断された。今回、3歳9ヵ月時に開窓部からの出血を主訴に当科へ受診となった。数日後に出血が治まったため、いったん終診となったが、4歳2ヵ月頃より唾仙痛様症状が出現したため再診した。口腔内所見および画像所見を踏まえて、開窓術後の変化を伴う口底部類表皮嚢胞と診断され、5歳時に全身麻酔下で嚢胞摘出術が行われた。その結果、病理組織学的に異所性胃腸管嚢胞と確定診断された。術後3年経過現在、再発なく、経過良好である。

researchmap

Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01073&link_issn=&doc_id=20230201450005&doc_link_id=10.5794%2Fjjoms.69.27&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.69.27&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

天疱瘡2例のLBC法における細胞像の検討

丸山智, 山崎学, 阿部達也, 田沼順一

新潟県臨床細胞学会会報 ( 37 ) 54 - 54 2022.12

Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature Review Reviewed

Tatsuya Abé, Manabu Yamazaki, Satoshi Maruyama, Nobuyuki Ikeda, Yoshimasa Sumita, Kei Tomihara, Jun-ichi Tanuma

diagnotics 12 ( 2398 ) 2398 - 2398 2022.12

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Adenosquamous carcinoma (ASC) is an aggressive subtype of squamous cell carcinoma (SCC). Due to its poor prognosis, a precise pathological diagnosis of ASC is essential but challenging because its pathological criteria are still unclear. Here, we present a rare case of oral ASC accompanied by acantholytic features. The tumor was raised in the mandibular gingiva and recurred locally approximately 13 months after the initial surgery with cervical lymph node metastasis. Pathological specimens of the primary lesion showed acantholysis in a large area of the SCC. Mucous cells, the characteristic finding indicating glandular differentiation, were imperceptible in the initial surgical specimen but increased in the locally recurrent and metastatic lymph node specimens. In a comprehensive literature review of oral ASC cases, the present case was the only case of ASC with acantholytic features. We reconfirmed that ASC has poor prognoses, such as low 5-year overall survival and disease-free survival, high locoregional recurrence, and high distant metastasis rates. A precise diagnosis of ASC is required for estimating prognosis and undergoing close follow-up, even if the adenocarcinomatous component is limited to a small area in the lesion.

File： diagnostics-12-02398.pdf

DOI： 10.3390/diagnostics12102398

researchmap

Clinicopathologic factors influencing the screening accuracy of oral cytology: A retrospective cohort study Reviewed International journal

MASAMI KAWAHARADA, SATOSHI MARUYAMA, MANABU YAMAZAKI, TATSUYA ABÉ, NYEIN NYEIN CHAN, AKINORI FUNAYAMA, ATSUSHI UENOYAMA, TOSHIYUKI AKIMORI, KEI TOMIHARA, JUN-ICHI TANUMA

Oncology letters 24 ( 385 ) 385 - 385 2022.10

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Cytology is a simple and non-invasive screening method for oral cancer. However, this method is not yet routinely used by clinicians because of its high false negative rate (FNR) and due to lack of sufficient studies examining the factors for high FNRs. The present retrospective study aimed to compare the screening performance of conventional cytology (CC) and liquid-based cytology (LBC) through histological validation, and to elucidate factors inducing false negative screening in oral cytology. Cytological specimens with histological examination and intraoral digital images of the lesion were retrospectively collected between January 2017 and December 2018 for CC and between October 2019 and September 2021 for LBC. Oral cytological screening was conducted based on the oral Bethesda system for oral cytology. Clinical subtypes were re-evaluated using intraoral digital images. The screening accuracy of oral cytology was calculated considering the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for detecting the malignant transformation of oral lesions. No statistically significant difference was noted in the inadequate rate between CC and LBC groups. For CC and LBC, the sensitivities were 60.9 and 59.2%, the specificities were 87.3 and 79.1%, the PPVs were 85.8 and 76.2%, and the NPVs were 63.9 and 63.2%, respectively. Thus, the screening accuracy was similar between methodologies. Among the clinicopathological factors investigated, histological diagnosis and cellularity contributed to false negative results. Homogeneous findings of oral epithelial dysplasia and the superficial growth of carcinoma in situ/squamous cell carcinoma resulted in false negative findings for CC and LBC. Furthermore, LBC samples with a lower cell number (<2,000 squamous cells) exhibited statistically significantly increased FNRs. The present study found that the cytological methods did not affect the inadequate rate and screening accuracy, whereas clinical subtype and cellularity decreased screening accuracy. Therefore, cytological screening and subsequent follow-up should be performed while considering clinical findings and the cellularity of cytology smears.

File： ol_24_5_13505_PDF.pdf

DOI： 10.3892/ol.2022.13505

PubMed

researchmap

Oral cytology can easily spot serious diseases Invited

Dental Outlook 140(3) ( 9 ) 500 - 508 2022.9

Metastasis of pulmonary adenocarcinoma to the oral cavity: A case report and literatures review of the last 30 years Reviewed

Masami Kawaharada, Satoshi Maruyama, Tatsuya Abé, Takafumi Hayashi, Tadaharu Kobayashi, Jun‐ichi Tanuma

Oral Science International 1 - 6 2022.9

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

File： Oral Science International - 2022 - Kawaharada - Metastasis of pulmonary adenocarcinoma to the oral cavity A case report.pdf

DOI： 10.1002/osi2.1130

researchmap

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/osi2.1130

Rosai-Dorfman disease of the maxilla: A rare case report and literature review Reviewed

Takahiro Nagai, Manabu Yamazaki, Atsushi Nishikawa, Yasumitsu Kodama, Hideyoshi Nishiyama, Takafumi Hayashi, Jun-ichi Tanuma, Ritsuo Takagi, Kei Tomihara

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 34 ( 5 ) 665 - 671 2022.9

Novel cytological model for the identification of early oral cancer diagnostic markers: The carcinoma sequence model. Invited Reviewed International journal

Masami Kawaharada, Manabu Yamazaki, Satoshi Maruyama, Tatsuya AbÉ, Nyein Nyein Chan, Taiichi Kitano, Tadaharu Kobayashi, Takeyasu Maeda, Jun-Ichi Tanuma

Oncology letters 23 ( 3 ) 76 2022.3

Language：English Publishing type：Research paper (scientific journal)

Most oral squamous cell carcinomas (OSCCs) arise from a premalignant lesion, oral epithelial dysplasia; however, useful markers for the early detection of OSCC are lacking. The present study aimed to establish a novel experimental model to observe changes in the sequential expression patterns of mRNAs and proteins in a rat model of tongue cancer using liquid-based cytology techniques. Cytology specimens were collected at 2, 5, 8, 11, 14, 17 and 21 weeks from rats treated with 4-nitroquinoline 1-oxide to induce tongue cancer. The expression of candidate biomarkers was examined by performing immunocytochemistry and reverse transcription-quantitative PCR. The percentage of positively stained nuclei was calculated as the labeling index (LI). All rats developed OSCC of the tongue at 21 weeks. The mRNA expression levels of bromodomain protein 4 (Brd4), c-Myc and Tp53 were upregulated during the progression from negative for intraepithelial lesion or malignancy to squamous cell carcinoma (SCC). Brd4- and c-Myc-LI increased in low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion and SCC specimens. p53-LI was significantly increased in SCC specimens. This novel experimental model allowed the observation of sequential morphological changes and the expression patterns of mRNAs and proteins during carcinogenesis. Combining immunocytochemistry with cytology-based diagnoses may potentially improve the diagnostic accuracy of OSCC.

File： ol_23_3_13196_PDF.pdf

DOI： 10.3892/ol.2022.13196

PubMed

researchmap

口腔上皮の反応異型と上皮内扁平上皮癌

田沼順一

病理と臨床 40 ( 3 ) 281 - 283 2022.3

Melanotic neuroectodermal tumor of infancy in the mandible: A case report. Reviewed International journal

Ryoko Takeuchi, Akinori Funayama, Yohei Oda, Tatsuya Abé, Manabu Yamazaki, Satoshi Maruyama, Takafumi Hayashi, Jun-Ichi Tanuma, Tadaharu Kobayashi

Medicine 100 ( 50 ) e28001 2021.12

Language：English Publishing type：Research paper (scientific journal)

RATIONALE: Melanocytic neuroectodermal tumor of infancy (MNTI) is a rare benign pigmented neoplasm that arises from the neural crest and has an aggressive growth pattern. It is predominantly seen in infants under 1 year of age, and the most common site of involvement is the maxilla. The currently accepted treatment is removal by surgical resection. Herein, we report a case of MNTI that involved the anterior alveolar ridge of the mandible in a 6-month-old infant. PATIENT CONCERNS: A case of a 6-month-old male child with a huge mass in the anterior alveolar ridge of the mandible. DIAGNOSIS: The tumor was diagnosed using histopathological and immunohistochemical techniques on the biopsy specimen obtained following incisional biopsy. Based on the findings, a final diagnosis of MNTI was established. INTERVENTIONS: Radical resection of the tumor was performed, after determining the extent of resection by referring to the mandibular 3D model created using the pre-operative CT data. OUTCOMES: The postoperative course was uneventful, and no recurrence has been observed to date for more than 4 years after surgery. LESSONS: This case emphasizes that early diagnosis and radical surgery are critical to the effective treatment, as MNTI exhibits rapid and destructive growth. It also requires careful and close follow-up because of high recurrence rates.

File： Melanotic_neuroectodermal_tumor_of_infancy_in_the.24.pdf

DOI： 10.1097/MD.0000000000028001

PubMed

researchmap

Other iatrogenic immunodeficiency-associated lymphoproliferative disorders in the oral cavity: a clinicopathologic study of 4 cases and literature review Reviewed

Masami Kawaharada, Satoshi Maruyama, Tatsuya Abé, Manabu Yamazaki, Akira Kurokawa, Wataru Katagiri, Ritsuo Takagi, Takafumi Hayashi, Tadaharu Kobayashi, Jun-ichi Tanuma

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 132 ( 6 ) 687 - 697 2021.12

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

Objectives: Other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OI-LPD) have been reported as one of the adverse effects of immunosuppressive therapy. The aim of this study was to describe the clinicopathologic and immunohistochemical features of OI-LPD in the oral cavity. Study Design: Immunohistochemistry was performed to describe the immunohistochemical features in our 4 cases. The results were analyzed along with 62 cases of oral OI-LPD in the English and Japanese literature to define clinical and pathologic characteristic features. Results: In our immunohistochemical analysis, Epstein-Barr virus (EBV)–positive OI-LPD showed a higher percentage of mouse double minute 2–positive cells than EBV-negative samples. A literature survey revealed that OI-LPD (including the present cases) arises primarily in the gingiva, followed by the tongue, and usually occurs with a male-to-female ratio of 1:1.9. The rate of EBV positivity was 93.8%. Further, 31 of 66 patients had osteonecrosis of the jaw and 24 of 31 patients had taken multiple immunosuppressive drugs in combination. Conclusions: We can therefore conclude that the overexpression of mouse double minute 2 in OI-LPD is associated with EBV infection, and the combination of multiple immunosuppressive drugs may be a risk factor for osteonecrosis of the jaw.

File： 1-s2.0-S2212440321004648-main.pdf

DOI： 10.1016/j.oooo.2021.05.015

Scopus

PubMed

researchmap

　 PREV - NEXT 　

<TANUMA Junichi>

Papers - TANUMA Junichi