Faculty Profiles - TANUMA Junichi

Papers - TANUMA Junichi

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Low-grade myofibroblastic sarcoma of the tongue with difficulty of diagnosis: a case report and review of the literature. Reviewed

Kawaharada M, Katagiri W, Maruyama S, Nishiyama H, Hayashi T, Kobayashi T, Tanuma J

Journal of Oral and Maxillofacial Surgery, Medicine and Pathology 33 ( 1 ) 93 - 97 2021.1

Corrigendum to “An ectomesenchymal chondromyxoid tumour on the lateral border of the tongue” [Int J Oral Maxillofac Surg 49 (2020) 1290–1203] (International Journal of Oral … Maxillofacial Surgery (2020) 49(10) (1290–1293), (S0901502720301399), (10.1016/j.ijom.2020.04.010))

K. Sakurai, K. Nakamori, M. Yamazaki, J. I. Tanuma

International Journal of Oral and Maxillofacial Surgery 2021

口腔細胞診のベセスダシステムとLBC法の標本作製 Invited

田沼順一

細胞検査士会報 68 ( 1 ) 3 - 7 2020.12

17年を経過して再減量手術を行った上顎骨線維性異形成症の1例

伊藤元貴, 児玉泰光, 大貫尚志, 高村真貴, 林孝文, 阿部達也, 田沼順一, 小林正治, 高木律男

新潟歯学会雑誌 50 ( 2 ) 79 - 85 2020.12

Frequent Germline and Somatic Single Nucleotide Variants in the Promoter Region of the Ribosomal RNA Gene in Japanese Lung Adenocarcinoma Patients Reviewed International journal

Riuko Ohashi, Hajime Umezu, Ayako Sato, Tatsuya Abé, Shuhei Kondo, Kenji Daigo, Seijiro Sato, Norikazu Hara, Akinori Miyashita, Takeshi Ikeuchi, Teiichi Motoyama, Masashi Kishi, Tadahiro Nagaoka, Keiko Horiuchi, Atsushi Shiga, Shujiro Okuda, Tomoki Sekiya, Aya Ohtsubo, Kosuke Ichikawa, Hiroshi Kagamu, Toshiaki Kikuchi, Satoshi Watanabe, Jun-Ichi Tanuma, Peter Schraml, Takao Hamakubo, Masanori Tsuchida, Yoichi Ajioka

Cells 9 ( 11 ) 2409 - 2409 2020.11

Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Ribosomal RNA (rRNA), the most abundant non-coding RNA species, is a major component of the ribosome. Impaired ribosome biogenesis causes the dysfunction of protein synthesis and diseases called “ribosomopathies,” including genetic disorders with cancer risk. However, the potential role of rRNA gene (rDNA) alterations in cancer is unknown. We investigated germline and somatic single-nucleotide variants (SNVs) in the rDNA promoter region (positions −248 to +100, relative to the transcription start site) in 82 lung adenocarcinomas (LUAC). Twenty-nine tumors (35.4%) carried germline SNVs, and eight tumors (9.8%) harbored somatic SNVs. Interestingly, the presence of germline SNVs between positions +1 and +100 (n = 12; 14.6%) was associated with significantly shorter recurrence-free survival (RFS) and overall survival (OS) by univariate analysis (p < 0.05, respectively), and was an independent prognostic factor for RFS and OS by multivariate analysis. LUAC cell line PC9, carrying rDNA promoter SNV at position +49, showed significantly higher ribosome biogenesis than H1650 cells without SNV. Upon nucleolar stress induced by actinomycin D, PC9 retained significantly higher ribosome biogenesis than H1650. These results highlight the possible functional role of SNVs at specific sites of the rDNA promoter region in ribosome biogenesis, the progression of LUAC, and their potential prognostic value.

File： cells-09-02409-v2.pdf

DOI： 10.3390/cells9112409

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前舌腺に発生した腺癌NOSの1例

三上俊彦, 船山昭典, 西山秀昌, 山崎学, 田沼順一, 小林正治

日本口腔外科学会雑誌 66 ( 11 ) 553 - 558 2020.11

Language：Japanese Publisher：(公社)日本口腔外科学会

52歳女。舌の違和感を主訴に近医を受診し、右側舌腫瘍を指摘された。他院のMRIで腫瘍性病変を認められ、当科での加療を勧められて来院した。右側舌下面粘膜下に15×15×15mm大の比較的境界明瞭な弾性硬の腫瘤を認めた。画像所見からは腺系腫瘍が示唆され、良悪性を含めた病理組織学的診断目的に生検を行ったが、組織型の確定には至らず、舌癌の診断のもと全身麻酔下に舌部分切除術を施行した。切除標本の病理組織所見は、淡明細胞の胞巣状増殖が主体ながら、粘液産生を示す二相性腺管がわずかに混在していたことから、鑑別疾患として筋上皮癌、上皮筋上皮癌、多型腺癌、明細胞癌が挙げられた。免疫染色によって筋上皮癌、上皮筋上皮癌、多型腺癌は否定され、EWSR1遺伝子のFISH解析によって明細胞癌も否定されたため腺癌NOS(not otherwise specified)と診断した。術後4年の現在まで再発・転移は認めていない。

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01073&link_issn=&doc_id=20201130470003&doc_link_id=10.5794%2Fjjoms.66.553&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.66.553&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Rac1-dependent phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: A possible driving force for tumor progression. Reviewed International journal

Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Masayuki Tsuneki, Hiroko Kato, Kenji Izumi, Jun-Ichi Tanuma, Jun Cheng, Takashi Saku

Experimental cell research 392 ( 1 ) 112013 - 112013 2020.7

Language：English Publishing type：Research paper (scientific journal)

Apoptotic cell death frequently occurs in human cancer tissues including oral squamous cell carcinoma (SCC), wherein apoptotic tumor cells are phagocytosed not only by macrophages but also by neighboring tumor cells. We previously reported that the engulfment of apoptotic SCC cells by neighboring SCC cells frequently occurs at the invading front. Therefore, we hypothesized that the phagocytosis of these apoptotic cells by tumor cells contributes to disease progression. Herein, using cultured oral SCC cells, we aimed to confirm whether tumor cells actually phagocytose apoptotic cells and to examine whether cellular activities are regulated by the phagocytosis of apoptotic cells. Co-culture experiments showed that living cells could ingest apoptotic cells into phagolysosomes. NSC23766, an inhibitor of Rac1, which is a key regulator of phagocytic cup formation in professional phagocytes, dramatically suppressed the phagocytosis of apoptotic cells by living cells. Additionally, cell migration and the secretion of DKK1, a tumor-promoting protein, were enhanced by co-culture with apoptotic cells, whereas NSC23766 inhibited these effects. These results show that tumor cells can actively phagocytose apoptotic neighbors in a Rac1-dependent manner and that such activity increases their migration. The regulation of apoptotic cell phagocytosis thus represents new directions for therapeutic intervention for oral cancer.

File： 1-s2.0-S0014482720302354-main.pdf

DOI： 10.1016/j.yexcr.2020.112013

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An ectomesenchymal chondromyxoid tumour on the lateral border of the tongue. Reviewed International journal

K Sakurai, K Nakamori, M Yamazaki, J-I Tanuma

International journal of oral and maxillofacial surgery 2020.5

Language：English

Ectomesenchymal chondromyxoid tumour (ECT) is an extremely rare intraoral mesenchymal tumour. Most of these tumours have been identified on the anterior aspect of the dorsal surface of the tongue. ECT is difficult to diagnose because of its rarity. We report a case of ECT arising on the lateral border of the tongue in a 67-year-old woman. The tumour, measuring 20 × 10 mm in size, was surgically removed. Histopathologically, the tumour was composed of small polygonal cells arranged in sheets, with a myxoid or hyalinized stroma. The tumour boundary was clear; however, the tumour showed a multinodular structure expanding along the tongue surface without obvious capsule. Careful examination revealed the tumour nodule to be spreading in a skip lesion-like fashion away from the main part of the tumour in the striated muscle layer. Although there was no evidence of recurrence at 18 months after the surgery, our observations suggest that surgery for ECT resection with a safety margin is more appropriate than enucleation.

File： 1-s2.0-S0901502720301399-main.pdf

DOI： 10.1016/j.ijom.2020.04.010

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The usefulness of oral LBC for oral disease-Fast, cheap, and accurate of oral cytology- Invited Reviewed

Jun-ichi Tanuma

Niigata Dental Journal 50 ( 1 ) 1 - 6 2020.1

Masseter muscle hypertrophy: A case report Reviewed

Masayuki Tsuneki, Satoshi Maruyama, Manabu Yamazaki, Kanae Niimi, Tadaharu Kobayashi, Hideyoshi Nishiyama, Takafumi Hayshi, Jun-ichi Tanuma

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 31 ( 6 ) 428 - 431 2019.12

Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma. Reviewed International journal

Yoshimasa Sumita, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Jun Cheng, Ritsuo Takagi, Jun-Ichi Tanuma

Oncology reports 40 ( 5 ) 2487 - 2496 2018.11

Language：English Publishing type：Research paper (scientific journal)

Transcription factor SRY‑box 9 (SOX9) is a key regulator of chondrocyte differentiation and sex determination, and it is also involved in the progression of various types of human cancer. However, its putative association with oral squamous cell carcinoma (OSCC) remains elusive. The aim of the present study was to investigate the expression profiles of SOX9 in various oral epithelial lesions, including OSCC. We performed immunohistochemical analysis of SOX9 expression in surgical specimens of OSCC, which simultaneously exhibited different grades of epithelial lesions, and analyzed the correlation between SOX9 expression and several clinicopathological factors. Moreover, we performed immunofluorescent staining, western blot analysis and real‑time reverse transcription‑polymerase chain reaction to assess SOX9 expression in OSCC HSC‑3 (a metastatic cell line) and HSC‑4 (a non‑metastatic cell line) cell lines. In surgical specimens, SOX9 expression was detected in the nuclei of proliferating cells in areas with epithelial dysplasia and carcinoma in situ, but not in areas with normal epithelia. Nuclear SOX9 expression was observed in most SCC cells. Notably, cytoplasmic SOX9 expression was confirmed only in some SCC cells; however, cytoplasmic SOX9 expression was significantly and positively correlated with poor clinical outcomes. Both protein and mRNA expression of SOX9 were significantly higher in the HSC‑3 cell line than that in the HSC‑4 line. Notably, however, only HSC‑3 cells exhibited cytoplasmic localization of SOX9 expression. Our findings indicate that SOX9 may be involved in the tumorigenesis and progression of OSCC. Furthermore, its cytoplasmic expression represents a potential predictive biomarker for tumor aggressiveness and OSCC prognosis.

File： 2018SOX9 oncology report.pdf

DOI： 10.3892/or.2018.6665

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A case of glandular odontogenic cyst arising in the maxillary premolar region. Reviewed

Tanaka S, Kaneko Y, Inagaki Y, Nagayama M, Tanuma J, Sumitomo S

Jpn. J. Oral Maxillofac. Surg 64 ( 10 ) 577 - 581 2018.10

口腔の液状検体細胞診の可能性 Invited Reviewed

田沼順一

1 ( 1 ) 1 - 2 2018.6

口腔扁平上皮癌におけるSOX9細胞質発現は予後不良と関連する

田沼順一, 高木律男, 隅田賢正

新潟歯学会雑誌 48 ( 1 ) 55 - 56 2018.6

Gorham-Stout disease: Progressive massive osteolysis of the mandible Reviewed

Makoto Matsubara, Makoto Adachi, Jun-ichi Tanuma, Yasunori Muramatsu, Shinichiro Sumitomo

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 28 ( 2 ) 147 - 151 2016.3

Inflammatory Myofibroblastic Tumor Mimicking Apical Periodontitis. Reviewed International journal

Makoto Adachi, Kazuki Kiho, Genta Sekine, Takahisa Ohta, Makoto Matsubara, Takakazu Yoshida, Akitoshi Katsumata, Jun-ichi Tanuma, Shinichiro Sumitomo

Journal of endodontics 41 ( 12 ) 2079 - 82 2015.12

Language：English Publishing type：Research paper (scientific journal)

Inflammatory myofibroblastic tumors (IMTs) are rare. IMTs of the head and neck occur in all age groups, from neonates to old age, with the highest incidence occurring in childhood and early adulthood. An IMT has been defined as a histologically distinctive lesion of uncertain behavior. This article describes an unusual case of IMT mimicking apical periodontitis in the mandible of a 42-year-old man. At first presentation, the patient showed spontaneous pain and percussion pain at teeth #28 to 30, which continued after initial endodontic treatment. Panoramic radiography revealed a radiolucent lesion at the site. Cone-beam computed tomographic imaging showed osteolytic lesions, suggesting an aggressive neoplasm requiring incisional biopsy. Histopathological examination indicated an IMT. The lesion was removed en bloc under general anesthesia, and the patient manifested no clinical evidence of recurrence for 24 months. Lesions of nonendodontic origin should be included in the differential diagnosis of apical periodontitis. Every available diagnostic tool should be used to confirm the diagnosis. Cone-beam computed tomographic imaging is very helpful for differential diagnosis in IMTs mimicking apical periodontitis.

File： 1-s2.0-S0099239915008316-main.pdf

DOI： 10.1016/j.joen.2015.09.006

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A case of sinonasal undifferentiated carcinoma treated without radical resection Reviewed

Takahisa Ohta, Masayuki Motohashi, Yasunori Muramatsu, Shinichiro Sumitomo, Jun-ichi Tanuma, Michio Shikimori

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 27 ( 2 ) 216 - 220 2015.3

Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats. Reviewed

Masami Tanaka, Minoru Watanabe, Izuru Yokomi, Naoki Matsumoto, Katsuko Sudo, Hitoshi Satoh, Tsuneo Igarashi, Azusa Seki, Hitoshi Amano, Kiyoshi Ohura, Kakei Ryu, Shunichi Shibata, Motohiko Nagayama, Jun-ichi Tanuma

Experimental animals 64 ( 2 ) 121 - 8 2015

Language：English Publishing type：Research paper (scientific journal)

Rats with dwarfism accompanied by skeletal abnormalities, such as shortness of the limbs, tail, and body (dwarf rats), emerged in a Jcl-derived Sprague-Dawley rat colony maintained at the Institute for Animal Experimentation, St. Marianna University Graduate School of Medicine. Since the dwarfism was assumed to be due to a genetic mutation based on its frequency, we bred the dwarf rats and investigated their characteristics in order to identify the causative factors of their phenotypes and whether they could be used as a human disease model. One male and female that produced dwarf progeny were selected, and reproduction was initiated by mating the pair. The incidence of dwarfism was 25.8% among the resultant litter, and dwarfism occurred in both genders, suggesting that it was inherited in an autosomal recessive manner. At 12 weeks of age, the body weights of the male and female dwarf rats were 40% and 57% of those of the normal rats, respectively. In soft X-ray radiographic and histological examinations, shortening and hypoplasia of the long bones, such as the tibia and femur, were observed, which were suggestive of endochondral ossification abnormalities. An immunohistochemical examination detected an aggrecan synthesis disorder, which might have led to delayed calcification and increased growth plate thickening in the dwarf rats. We hypothesized that the principal characteristics of the dwarf rats were systemically induced by insufficient cartilage calcification in their long bones; thus, we named them cartilage calcification insufficient (CCI) rats.

DOI： 10.1538/expanim.14-0072

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Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats.

Experimental animals 64 ( 2 ) 121 - 8 2015

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1538/expanim.14-0072

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Potential for using lectin sugar chains as diagnostic markers in oral precancerous lesions Reviewed

Michiko Ehara, Juna Nakao, Motohiko Nagayama, Masaaki Shiota, Kiyoko F. Aoki-Kinoshita, Jun-ichi Tanuma

GLYCOBIOLOGY 24 ( 11 ) 1214 - 1215 2014.11