Faculty Profiles - TANUMA Junichi

Papers - TANUMA Junichi

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Carcinogenesis modifier loci in rat tongue are subject to frequent loss of heterozygosity. Reviewed

Jun-ichi Tanuma

International journal of cancer 102 638 - 642 2002.12

Language：English Publishing type：Research paper (scientific journal)

Rats of the DA strain are highly susceptible to 4NQO-induced TCs, whereas WF rats are barely susceptible. In (DA x WF)F2 rats, 5 QTL, Tscc1-5, are responsible for most of the phenotypic variations, though they do not account for all of the phenotypic differences between WF and DA rats. Analysis of 40 tongue tumors >5 mm in diameter from (DA x WF)F1 rats for LOH at the Tscc loci revealed a high frequency of LOH in chromosomal regions where the Tscc2, -3 and -4 loci map. In most cases of LOH, the allele of the barely susceptible WF strain was lost, suggesting that these loci in the WF strain encode tumor-suppressor genes. Analysis of the same tumors for somatic mutations in oncogenes indicated frequent alteration of Ha-ras, which maps in the Tscc3 region, but rare mutation of the p15(INK4B) and p16(INK4A) genes or the p53 and Msh2 genes. Frequent LOH was also found on rat chromosomes 5 (RNO5) and 6 (RNO6). Tumors of large size accumulated LOH at multiple loci, suggesting the involvement of Tscc loci in tumor progression.

DOI： 10.1002/ijc.10751

PubMed

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Solitary fibrous tumor in the mental region Reviewed

M Hirano, J Tanuma, T Shimoda, K Sugihara, M Tsuneyoshi, M Kitano

PATHOLOGY INTERNATIONAL 51 ( 11 ) 905 - 908 2001.11

Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat Reviewed

J Tanuma, K Fujii, M Hirano, H Matsuuchi, H Shisa, H Hiai, H Kitano

JAPANESE JOURNAL OF CANCER RESEARCH 92 ( 6 ) 610 - 616 2001.6

Biological and genetic characterization of a human immunodeficiency virus strain resistant to CXCR4 antagonist T134 Reviewed

K. Kanbara, S. Sato, J. I. Tanuma, H. Tamamura, K. Gotoh, M. Yoshimori, T. Kanamoto, M. Kitano, N. Fujii, H. Nakashima

AIDS Research and Human Retroviruses 17 ( 7 ) 615 - 622 2001

Solitary fibrous tumor in the mental region. Reviewed

Hirano M, Tanuma J, Shimoda T, Sugihara K, Tsuneyoshi M, Kitano M

Pathology International 51 905 - 908 2000.3

Polygenetic susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in the rat Reviewed

Jun-Ichi Tanuma, Motoo Kitano, Hayash Shisa, Hiroshi Hiai

Journal of Experimental Animal Science 41 ( 1-2 ) 68 - 77 2000

Mutation of p53 gene during 4NQO-induced tongue carcinogenesis in the Dark-Agouti rat. Reviewed

Kitano Motoo, Hirayama Yoshikazu, Tanuma Jun-ichi, Li Tie-Jun, HiranoMasato, Semba Ichiro

Reports of Kagoshima University Project. 3 ( * ) p137 - 144 1999

Propyinitrosourea-induced T-lymphomas in LEXF RI strains of rats: Genetic analysis Reviewed

L. M. Lu, H. Shisa, J. I. Tanuma, H. Hiai

British Journal of Cancer 80 ( 5-6 ) 855 - 861 1999

Random nuclear p53 overexpression pattern in tamoxifen-mediated endometrial carcinoma Reviewed

Y Kuwashima, M Kurosumi, Y Kobayashi, J Tanuma, K Suemasu, Y Higashi, T Kasamatsu, K Shiromizu, K Kishi

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY 17 ( 2 ) 135 - 139 1998.4

Quantitative trait loci affecting 4NQO-induced tongue carcinogenesis in the rat Reviewed

Tanuma J, Shisa H, Hiai H, Yamada Y, Kamoto T, Hirayama Y, Matsuuchi H, Kitano M

Cancer Research 58 ( 8 ) 1660 - 1664 1998.3

Language：English Publishing type：Doctoral thesis

The incidence of tongue carcinomas (TCs) induced by oral administration of 4-nitroquinoline 1-oxide in rats is strain dependent. The inbred Dark-Agouti (DA) strain showed a much higher susceptibility to large mass-forming infiltrative TCs than did the Wistar-Furth (WF) strain. Our previous study (M. Kitano et al, Jpn. J. Cancer Res., 87: 1097-1101, 1996) on crosses between these two strains postulated a dominant susceptibility gene in DA and a dominant resistance gene in WF rats. The present study mapped these loci by analyzing the backcrosses to each parent with simple sequence repeat polymorphisms. Five quantitative parameters were analyzed: (a) the number of TCs > 5 mm in diameter; (b) the total number of TCs per rat; (c) the diameter of the largest TCs (DTCmax values); (d) the number of non-TC cancers per rat; and (e) and the number of cancers of any site per rat. All of these parameters were closely correlated (P < 0.0001). DA rats had a semidominant gene (Stc1) favoring the development of 4-nitroquinoline 1-oxide-induced cancers on chromosome 19, closely linked to D19Mit9. Peak linkage was observed 4 cM distal from D19Mit9, with a logarithm of the odds (lod) score of 5.72 for

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Inverse correlation between bcl-2 expression and cell growth fraction in human Endometrial adenocarcinoma tissue. Reviewed

Kuwashima Y, Kobayashi Y, Kurozumi M, Tanuma J, Shiromizu K, Kishi K

Anticancer Res 17 3773 - 3776 1997.8

Genetic controls of the susceptibility and resistance to 4NQO-induced tongue carcinomas in the rats. Reviewed

Kitano M, Hirayama Y, Tanuma J, Matsuuchi H, Miura Y, Li T-J, Semba I, Kokubu T, Hatano H, Tada M, Kobayashi Y, Shisa H

Jpn. J. Cancer Res 87 1097 - 1101 1997.6

Occurrence of apoptotic DNA fragmentation in quiescent and proliferating cells in human endometrial adenocarcinoma tissues and the influence of apoptosis-suppressing effects of bcl-2 products. Reviewed

Kuwashima Y, Kobayashi Y, Kawarai A, Kurozumi M, Tanuma J, Shiromizu K, Kishi K

Anticancer Res 17 3737 - 3741 1997.5

The LEXF: A new set of rat recombinant inbred strains between LE/Stm and F344 Invited Reviewed

Hayase Shisa, Lingmin Lu, Hideki Katoh, Atsuko Kawarai, Jun-Ichi Tanuma, Yoshibumi Matsushima, Hiroshi Hiai

Mammalian Genome 8 ( 5 ) 324 - 327 1997.5

Tamoxifen mediated human endometrial carcinogenesis may not involve estrogenic pathways: A preliminary note Reviewed

Y Kuwashima, M Kurosumi, Y Kobayashi, J Tanuma, K Suemasu, Y Higashi, T Kasamatsu, K Shiromizu, M Matsuzawa, K Kishi

ANTICANCER RESEARCH 16 ( 5A ) 2993 - 2996 1996.9

Expression of bcl-2 and Apoptotic DNA Fragmentation in Human Endometrial Adenocarcinoma cells. Reviewed

Kuwashima Y, Kobayashi Y, Kawarai A, Kurozumi M, Uehara T, Tanuma J, Shiromizu K, Matsuzawa M, Kishi K

Anticancer Res 16 3221 - 3224 1996.5

Evaluation of Apoptosis in human endometrial adenocarcinoma: Comparison of Neck and Labelling Le(y) Antigen Immunostaining Method. Reviewed

Kuwashima Y, Kobayashi Y, Kawarai A, Kurozumi M, Tanuma J, Shiromizu K, Matsuzawa K, Kishi K

Anticancer Res 16 3225 - 3228 1996.5

Immunohistochemical detection of ras p21 oncoprotein in undifferentiated and well-differentiated epithelial carcinomas of the human ovary Reviewed

Y. Kuwashima, H. Shisa, T. Uehara, M. Kurosumi, Y. Kobayashi, J. Tanuma, K. Shiromizu, M. Matsuzawa, K. Kishi

Anticancer Research 15 ( 6 B ) 2847 - 2850 1995

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