Faculty Profiles - TANUMA Junichi

Papers - TANUMA Junichi

Division display 61 - 80 of about 105 ／ All the affair displays >>

口腔扁平上皮癌におけるSOX9細胞質発現は予後不良と関連する

田沼順一, 高木律男, 隅田賢正

新潟歯学会雑誌 48 ( 1 ) 55 - 56 2018.6

Gorham-Stout disease: Progressive massive osteolysis of the mandible Reviewed

Makoto Matsubara, Makoto Adachi, Jun-ichi Tanuma, Yasunori Muramatsu, Shinichiro Sumitomo

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 28 ( 2 ) 147 - 151 2016.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Ltd

Gorham-Stout disease (GSD) is an extremely rare massive osteolytic bone disease, and the pathogenesis and etiology are unknown. It is characterized by the uncontrolled proliferation of distended, thin-walled vascular and lymphatic channels within bone, which leads to resorption and replacement of the bone with angiomas and/or fibrosis.A 35-year-old man had complained of masticatory disturbance caused by mandibular teeth mobility and mandibular swelling for several years. He suffered from an eating disorder because of the severe mobility of his mandibular teeth, and he presented at our hospital for consultation. He had swelling and grade III mobility without pain
his skin was normal in color with a 70 mm × 50 mm lesion of elastic and firm texture at the submental region. The ill-defined mandibular bone destruction was seen radiographically. Magnetic resonance imaging (MRI) showed that the lesion occupied the submental region and inside the mandibular bone, and these lesions were isolated. The biopsy results suggested a diagnosis of lymphangioma. The patient received radical surgery, and histological examination suggested lymphangioma. We diagnosed GSD because massive osteolysis of the mandible associated with lymphangioma was seen in the lesion. The postoperative course was uneventful, with no local recurrence 36 months after surgery. Given the rarity of this disease entity, there is no standard therapy. The details of this case are presented, and diagnostic and management considerations are described.

File： 1-s2.0-S2212555815002008-main-2.pdf

DOI： 10.1016/j.ajoms.2015.09.007

Inflammatory Myofibroblastic Tumor Mimicking Apical Periodontitis. Reviewed International journal

Makoto Adachi, Kazuki Kiho, Genta Sekine, Takahisa Ohta, Makoto Matsubara, Takakazu Yoshida, Akitoshi Katsumata, Jun-ichi Tanuma, Shinichiro Sumitomo

Journal of endodontics 41 ( 12 ) 2079 - 82 2015.12

Language：English Publishing type：Research paper (scientific journal)

Inflammatory myofibroblastic tumors (IMTs) are rare. IMTs of the head and neck occur in all age groups, from neonates to old age, with the highest incidence occurring in childhood and early adulthood. An IMT has been defined as a histologically distinctive lesion of uncertain behavior. This article describes an unusual case of IMT mimicking apical periodontitis in the mandible of a 42-year-old man. At first presentation, the patient showed spontaneous pain and percussion pain at teeth #28 to 30, which continued after initial endodontic treatment. Panoramic radiography revealed a radiolucent lesion at the site. Cone-beam computed tomographic imaging showed osteolytic lesions, suggesting an aggressive neoplasm requiring incisional biopsy. Histopathological examination indicated an IMT. The lesion was removed en bloc under general anesthesia, and the patient manifested no clinical evidence of recurrence for 24 months. Lesions of nonendodontic origin should be included in the differential diagnosis of apical periodontitis. Every available diagnostic tool should be used to confirm the diagnosis. Cone-beam computed tomographic imaging is very helpful for differential diagnosis in IMTs mimicking apical periodontitis.

File： 1-s2.0-S0099239915008316-main.pdf

DOI： 10.1016/j.joen.2015.09.006

A case of sinonasal undifferentiated carcinoma treated without radical resection Reviewed

Takahisa Ohta, Masayuki Motohashi, Yasunori Muramatsu, Shinichiro Sumitomo, Jun-ichi Tanuma, Michio Shikimori

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 27 ( 2 ) 216 - 220 2015.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Ltd

Sinonasal undifferentiated carcinoma (SNUC) is a rare and highly aggressive neoplasm of the paranasal sinuses. SNUC is characterized by rapid expansion with high rates of recurrence and metastasis to cervical lymph nodes and distant sites. The patient was a 65-year-old woman who complained of persistant pain at the right maxilla. She had undergone endodontic therapy at the right first molar by her primary dentist. Imaging studies, including computed tomography (CT) and magnetic resonance imaging (MRI), showed a lesion occupying the right maxillary sinus and extending into the nasal cavity and ethmoid sinus. A malignant tumor of the maxillary sinus was suspected, and a biopsy was performed. The lesion was diagnosed as sinonasal undifferentiated carcinoma. The patient was treated with chemoradiation therapy. After 4 cycles of chemoradiation therapy, CT and MRI showed shrinkage of the lesion and changes consistent with necrosis. Histological examination of a repeat biopsy specimen after the 4 cycles of chemoradiation did not contain tumor cells. 2 more cycles of chemoradiation therapy were added. Six months after the initial diagnosis, CT finding suggested residual tumor in the ethmoid sinus. We performed another biopsy and the histopathological analysis was negative for tumor. The patient has been followed for 33 months since completing chemoradiation therapy, and there has not been any further evidence of disease.

File： 1-s2.0-S2212555813001828-main.pdf

DOI： 10.1016/j.ajoms.2013.10.001

Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats. Reviewed

Masami Tanaka, Minoru Watanabe, Izuru Yokomi, Naoki Matsumoto, Katsuko Sudo, Hitoshi Satoh, Tsuneo Igarashi, Azusa Seki, Hitoshi Amano, Kiyoshi Ohura, Kakei Ryu, Shunichi Shibata, Motohiko Nagayama, Jun-ichi Tanuma

Experimental animals 64 ( 2 ) 121 - 8 2015

Language：English Publishing type：Research paper (scientific journal)

Rats with dwarfism accompanied by skeletal abnormalities, such as shortness of the limbs, tail, and body (dwarf rats), emerged in a Jcl-derived Sprague-Dawley rat colony maintained at the Institute for Animal Experimentation, St. Marianna University Graduate School of Medicine. Since the dwarfism was assumed to be due to a genetic mutation based on its frequency, we bred the dwarf rats and investigated their characteristics in order to identify the causative factors of their phenotypes and whether they could be used as a human disease model. One male and female that produced dwarf progeny were selected, and reproduction was initiated by mating the pair. The incidence of dwarfism was 25.8% among the resultant litter, and dwarfism occurred in both genders, suggesting that it was inherited in an autosomal recessive manner. At 12 weeks of age, the body weights of the male and female dwarf rats were 40% and 57% of those of the normal rats, respectively. In soft X-ray radiographic and histological examinations, shortening and hypoplasia of the long bones, such as the tibia and femur, were observed, which were suggestive of endochondral ossification abnormalities. An immunohistochemical examination detected an aggrecan synthesis disorder, which might have led to delayed calcification and increased growth plate thickening in the dwarf rats. We hypothesized that the principal characteristics of the dwarf rats were systemically induced by insufficient cartilage calcification in their long bones; thus, we named them cartilage calcification insufficient (CCI) rats.

DOI： 10.1538/expanim.14-0072

Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats.

Masami Tanaka, Minoru Watanabe, Izuru Yokomi, Naoki Matsumoto, Katsuko Sudo, Hitoshi Satoh, Tsuneo Igarashi, Azusa Seki, Hitoshi Amano, Kiyoshi Ohura, Kakei Ryu, Shunichi Shibata, Motohiko Nagayama, Jun-ichi Tanuma

Experimental animals 64 ( 2 ) 121 - 8 2015

Language：English Publishing type：Research paper (scientific journal)

Rats with dwarfism accompanied by skeletal abnormalities, such as shortness of the limbs, tail, and body (dwarf rats), emerged in a Jcl-derived Sprague-Dawley rat colony maintained at the Institute for Animal Experimentation, St. Marianna University Graduate School of Medicine. Since the dwarfism was assumed to be due to a genetic mutation based on its frequency, we bred the dwarf rats and investigated their characteristics in order to identify the causative factors of their phenotypes and whether they could be used as a human disease model. One male and female that produced dwarf progeny were selected, and reproduction was initiated by mating the pair. The incidence of dwarfism was 25.8% among the resultant litter, and dwarfism occurred in both genders, suggesting that it was inherited in an autosomal recessive manner. At 12 weeks of age, the body weights of the male and female dwarf rats were 40% and 57% of those of the normal rats, respectively. In soft X-ray radiographic and histological examinations, shortening and hypoplasia of the long bones, such as the tibia and femur, were observed, which were suggestive of endochondral ossification abnormalities. An immunohistochemical examination detected an aggrecan synthesis disorder, which might have led to delayed calcification and increased growth plate thickening in the dwarf rats. We hypothesized that the principal characteristics of the dwarf rats were systemically induced by insufficient cartilage calcification in their long bones; thus, we named them cartilage calcification insufficient (CCI) rats.

DOI： 10.1538/expanim.14-0072

Potential for using lectin sugar chains as diagnostic markers in oral precancerous lesions Reviewed

Michiko Ehara, Juna Nakao, Motohiko Nagayama, Masaaki Shiota, Kiyoko F. Aoki-Kinoshita, Jun-ichi Tanuma

GLYCOBIOLOGY 24 ( 11 ) 1214 - 1215 2014.11

Hypomineralized Enamel of Dens Invaginatus: Its distinct images and pathogenesis of the Type III invagination using micro-focusing computed tomography Reviewed

Maiko Yamada, Motohiko Nagayama, Akitoshi Katsumata, Satoshi Kawano, Keika Gen, Michiko Ehara, Juna Nakao, Jun-ichi Tanuma, Takakazu Yoshida

JOURNAL OF HARD TISSUE BIOLOGY 23 ( 4 ) 449 - 453 2014.10

Language：English Publishing type：Research paper (scientific journal) Publisher：JOURNAL HARD TISSUE BIOLOGY

Dens invaginatus (DI) is one of the rare developmental tooth anomaly, and generally resulting from invagination of the inner enamel epithelium into the dental papilla before calcification. However, it remains unclear whether the invaginated enamel mineralizaion is lower than outer enamel, the association with the resistance to invaginated enamel caries and the inflammatory lesions mediated their invagination. Because of the difficulties of treating and the tendency of their inflammatory lesions mediated their malformed structures, teeth extracted from the patients with DI, were collected in our hospital and analyzed by three-dimensional micro-focusing computed tomography (mu CT) to clarify the differences of the invaginated enamel in mineral density (MD), and to find their pathogenesis of tooth anomaly and associated inflammatory lesions by histological analysis. The teeth were fixed with 10% formaldehyde and analyzed by mu CT, decalcified specimens were performed to histological (HE) and immunohistochemistry for cytokeratin AE1/AE3. All invaginated teeth enamel showed extremely lower MD than did the outer enamel. Interestingly there were no carious lesions in the invaginated enamel. HE showed thin reduced enamel epithelium on the surface of invaginated enamel and cytokeratin AE1/AE3 markedly showed positive their cellular matrix. The persistent reduced enamel epithelium of the invaginated enamel indicates delayed or inhibited maturation after tooth eruption. This failure of maturation results in lower MD but resistance to enamel caries. However, the structural abnormalities of DI teeth may allow bacteria to enter the interior of the tooth through the invagination, causing pulpitis or apical periodontitis. (243 words)

File： 23_449.pdf

DOI： 10.2485/jhtb.23.449

Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis. Reviewed International journal

Hirohiko Suwa, Masato Hirano, Kouji Kawarada, Motohiko Nagayama, Michiko Ehara, Tomonari Muraki, Hayase Shisa, Aiko Sugiyama, Masahiro Sugimoto, Hiroshi Hiai, Motoo Kitano, Jun-Ichi Tanuma

Oncology reports 31 ( 1 ) 3 - 12 2014.1

Language：English Publishing type：Research paper (scientific journal)

Susceptibly to the induction of rat tongue cancer (TC) by oral 4-nitroquinoline 1-oxide (4NQO) exposure is a polygenic trait. Among several quantitative trait loci identified by crosses between TC-susceptible Dark Agouti (DA) rats and TC-resistant Wistar-Furth (WF) rats, we focused on tongue cancer susceptibility locus (Tcas3) of chromosome 4. We examined tongue carcinogenesis in the reciprocal congenic strains DA.WF-Tcas3 and WF.DA-Tcas3 and in their parental strains. The Tcas3DA allele, and not the Tcas3WF allele, significantly favored tumor latency, incidence and TC number/size. In genomic DNA of TCs induced in (DA x WF) F1 rats, the resistant Tcas3WF allele was frequently and selectively lost, particularly in larger tumors. Thus, we searched the possible candidate genes in the Tcas3 region using microarray analysis of TCs in F1 rats and revealed significant upregulation of 2 cancer-related genes, parathyroid hormone-like hormone (Pthlh) and Kras2. The relevance of the WF allele of Pthlh as a cancer modifier was indicated by 3 single nucleotide polymorphisms specific to this strain. In contrast, no consistent strain-specific variations were found in Kras2. Moreover, the plasma Ca2+ level was consistently higher in DA rats when compared to the level in WF rats bearing TCs; moreover, the Pthlh-mRNA expression level was >30-fold higher in TCs when compared to this level in the normal tongue mucosa. Immunostaining experiments showed strong PTHrP protein expression in TCs of DA rats, and the signal was intensified in larger TCs. Kras2 was also upregulated in TCs, but to a lesser degree than PTHrP. Thus, Pthlh is a promising candidate modifier gene in the development and progression of rat TCs.

DOI： 10.3892/or.2013.2859

Intraneural perineurioma arising in the lateral border of the tongue. Reviewed International journal

Masato Hirano, Tomonori Muraki, Motohiko Nagayama, Michiko Ehara, Kouji Kawarada, Hirohiko Suwa, Motoo Kitano, Jun-ichi Tanuma

Pathology international 63 ( 12 ) 619 - 21 2013.12

Basaloid squamous cell carcinoma of the tongue: a case report. Reviewed

Matsui R, Tanuma J, Kwashima K, Miyahara M, Semba I, Sugihara K

Oral Medicine & Oral Pathology 15 117 - 122 2011.2

FGFR4 polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma. Reviewed International journal

Jun-Ichi Tanuma, Toshiyuki Izumo, Masato Hirano, Yoshitaka Oyazato, Fumiya Hori, Eri Umemura, Hayase Shisa, Hiroshi Hiai, Motoo Kitano

Oncology reports 23 ( 3 ) 739 - 44 2010.3

Language：English Publishing type：Research paper (scientific journal)

The genotype of the fibroblast growth factor receptor 4 (FGFR4) gene and TP53 mutation have been reported as prognostic factors for cancers of the head and neck, bladder, breast and colon. To determine whether they are applicable for oral squamous cell carcinoma (OSCC), we investigated these two genes in OSCC samples from 150 patients who had undergone radical surgery and in 100 cancer-free individuals. In OSCC, the FGFR4 Gly388Arg polymorphism and the presence or absence of mutation in TP53 did not show a significant association with the clinicopathological features of the tumors at surgery. However, the FGFR4 Arg388 allele, as well as mutations in TP53, was found to be closely associated with poor prognosis. Moreover, these two parameters synergistically affected the survival of OSCC patients. During 60 months of observation after radical surgery, a majority of patients with homozygous Arg388 FGFR4 plus mutated TP53 died of cancer, whereas >90% patients carrying homozygous Gly388 FGFR4 plus wild-type TP53 survived. Therefore, the FGFR4 Gly388Arg polymorphism and TP53 mutations, as well as their combinations, are excellent predictors of the prognosis for OSCC patients.

DOI： 10.3892/or-00000692

Tumor lymphangiogenesis correlates with lymph node metastasis and clinicopathologic parameters in oral squamous cell carcinoma. Reviewed International journal

Mayumi Miyahara, Jun-Ichi Tanuma, Kazumasa Sugihara, Ichiro Semba

Cancer 110 ( 6 ) 1287 - 94 2007.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Lymphatic vessel density (LVD) and microvessel density (MVD) are important parameters for assessing the malignant potential of tumors and patient survival. In this report, the authors defined LVD as the density of D2-40-positive lymphatic vessels and MVD as the density of CD105-positive microvessels per unit area of tissue. It was reported previously that vascular endothelial growth factor C (VEGF-C) is a major modulator of LVD and MVD. The objectives of this study were to clarify the clinical and prognostic significance of both LVD and MVD in oral squamous cell carcinoma (OSCC) and to elucidate the lymphangiogenic and angiogenic activities of VEGF-C in cancer tissues. METHODS: In total, 110 OSCC tissue samples were evaluated for LVD, MVD, and expression of VEGF-C using immunohistochemistry. Correlations among these parameters and clinicopathologic factors were examined. RESULTS: LVD was significantly higher in tumors that had very high expression of VEGF-C compared with tumors that had no/weak expression of VEGF-C. LVD correlated well with lymph node metastasis (P < .001). MVD was correlated significantly with positive lymph node metastasis (P < .001) but not with VEGF-C expression. In contrast, high expression of VEGF-C was correlated significantly with advanced tumor status (P = .041). Survival rates were lower in patients who had higher LVD (P < .001), higher MVD (P = .0028), and strong VEGF-C expression (P = .048). CONCLUSIONS: Lymphangiogenesis predominantly influenced metastasis-free survival. The current results suggested that LVD is a more useful tool than MVD and VEGF-C for deciding on therapeutic strategies in patients with OSCC.

DOI： 10.1002/cncr.22900

DRH strains: genetic resistance to chemical hepatocarcinogenesis. Reviewed

Hiai H, Liu H, Omi N, Tanuma J, Higashi K

Trends in Cancer Research 2 127 - 134 2007.4

Pleomorphic adenoma presenting low T-2 signal-intensity on magnetic resonance imaging Reviewed

H. Indo, S. Suenaga, E. Nozoe, N. Nakamura, J. Tanuma, I. Semba, H. J. Majima

DENTOMAXILLOFACIAL RADIOLOGY 35 ( 5 ) 380 - 382 2006.9

Language：English Publishing type：Research paper (scientific journal) Publisher：BRITISH INST RADIOLOGY

We report an unusual case of pleomorphic adenoma of the submandibular gland in a 48-year-old female. The present case appeared as a relatively homogeneous, low to intermediate signal-intensity on the T-2 weighted magnetic resonance (MR) images. To our knowledge, the MR feature of low T-2 signal-intensity of pleomorphic adenoma has not been reported in the literature.

DOI： 10.1259/dmfr/21157218

Selective loss of resistant alleles at p15INK4B and p16INK4A genes in chemically-induced rat tongue cancers. Reviewed International journal

Kotaro Ogawa, Jun-ichi Tanuma, Masato Hirano, Yoshikazu Hirayama, Ichiro Semba, Hayase Shisa, Motoo Kitano

Oral oncology 42 ( 7 ) 710 - 7 2006.8

Language：English Publishing type：Research paper (scientific journal)

We previously reported that susceptibility to 4-nitroquinoline 1-oxide (4NQO)-induced tongue cancer in Dark-Agouti (DA) and Wistar/Furth (WF) rats was determined by a number of quantitative trait loci. In this article, we further scrutinized one of the quantitative trait loci at a suggestive level on rat chromosome 5. Analyzing a DNA panel of 130 (DAxWF) F2 rats treated with 4NQO showed a quantitative trait loci, containing p15INK4B and p16INK4A. To study the possible relevance of these genes in the development of tongue cancer, we examined 45 4NQO-induced tongue cancers in 100 (DAxWF) F1 rats for loss of heterozygosity. The incidence of loss of heterozygosity at p15INK4B and p16INK4A genes in large advanced tongue cancers was 37.8% and 40.0%, respectively, and the WF allele was selectively lost. Accumulation of loss of heterozygosity and methylation of the promoter regions in the tumour suppressor genes in advanced tumours suggests that they may play a role in tongue cancer progression.

DOI： 10.1016/j.oraloncology.2005.11.011

Immunohistological evaluation of Ki-67, p63, CK 19 and pS3 expression in oral epithelial dysplasias Reviewed

T. Takeda, K. Sugihara, Y. Hirayama, M. Hirano, J-I Tanuma, I. Semba

JOURNAL OF ORAL PATHOLOGY & MEDICINE 35 ( 6 ) 369 - 375 2006.7

Language：English Publishing type：Research paper (scientific journal) Publisher：BLACKWELL PUBLISHING

BACKGROUND: Oral squamous cell carcinoma develops through a multistep of genetic mutations, and the process can be morphologically recognized as oral epithelial dysplasia. To evaluate the hypothesis that distributional alterations of proliferating and stem cells may be a useful index to estimate the grading and development of epithelial dysplasia, we examined the distribution patterns according to stratified cell layers.
METHODS: Sixty-two oral dysplasia cases according to the histological grades were immunohistologically examined and the nuclear expression of Ki-67 and p63 antigens was counted according to epithelial layers as labeling index.
RESULTS: The Ki-67 labeling index in the basal and suprabasal layers and that of p63 in the basal layer showed a significant difference between low- and high-grade groups of epithelial dysplasia.
CONCLUSION: The architectural alteration of proliferating cell and stem cell distribution in the layers of epithelial dysplasias may provide useful information to evaluate the grading of oral epithelial dysplasias.

Immunohistological evaluation of Ki-67, p63, CK19 and p53 expression in oral epithelial dysplasias Reviewed

T. Takeda, K. Sugihara, Y. Hirayama, M. Hirano, J. I. Tanuma, I. Semba

Journal of Oral Pathology and Medicine 35 ( 6 ) 369 - 375 2006.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Oral squamous cell carcinoma develops through a multistep of genetic mutations, and the process can be morphologically recognized as oral epithelial dysplasia. To evaluate the hypothesis that distributional alterations of proliferating and stem cells may be a useful index to estimate the grading and development of epithelial dysplasia, we examined the distribution patterns according to stratified cell layers. METHODS: Sixty-two oral dysplasia cases according to the histological grades were immunohistologically examined and the nuclear expression of Ki-67 and p63 antigens was counted according to epithelial layers as labeling index. RESULTS: The Ki-67 labeling index in the basal and suprabasal layers and that of p63 in the basal layer showed a significant difference between low- and high-grade groups of epithelial dysplasia. CONCLUSION: The architectural alteration of proliferating cell and stem cell distribution in the layers of epithelial dysplasias may provide useful information to evaluate the grading of oral epithelial dysplasias. © Blackwell Munksgaard 2006 · All rights reserved.

DOI： 10.1111/j.1600-0714.2006.00444.x

A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from Dark-Agouti rats. Reviewed International journal

Masato Hirano, Jun-Ichi Tanuma, Yoshikazu Hirayama, Masanobu Ohyama, Ichiro Semba, Shinya Wakusawa, Hayase Shisa, Hiroshi Hiai, Motoo Kitano

Cancer letters 231 ( 2 ) 185 - 91 2006.1

Language：English Publishing type：Research paper (scientific journal)

We previously reported that Dark-Agouti (DA) rats are highly susceptible to 4-nitroquinoline 1-oxide (4NQO)-induced tongue cancer (TC), whereas Wistar/Furth (WF) rats are barely susceptible. Linkage analysis of reciprocal (DAxWF)F2 rats demonstrated five quantitative trait loci, Tongue squamous cell carcinoma 1-5 (Tscc1-5) determining the size and number of the TCs. The major susceptibility locus Tscc1 is mapped on rat chromosome 19. In the present study, we used a marker-assisted speed congenic procedure to construct WF.DA-Tscc1 (WF-T1D) rats, i.e. WF rats carrying a DA-derived Tscc1 chromosomal segment, and evaluated the effect of a single Tscc1 on 4NQO-induced tongue carcinogenesis. In WF-T1D rats, the incidence, number and size of 4NQO-induced TCs were significantly higher than those in WF rats, indicating that the introgressed segment contains one of the susceptibility loci for 4NQO-induced TCs from DA rats. Detection of a single nucleotide polymorphism in NQO1, one of the Tscc1 candidate genes, enabled us to map NQO1 in the Tscc1 segment between D19Wox8 and D19Wox7 on chromosome 19. Possible relevance of NQO1 polymorphism to TC susceptibility is discussed.

DOI： 10.1016/j.canlet.2005.01.043

FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer. Reviewed International journal

Monica Spinola, Vera Piera Leoni, Jun-Ichi Tanuma, Angela Pettinicchio, Milo Frattini, Stefano Signoroni, Roberto Agresti, Riccardo Giovanazzi, Silvana Pilotti, Lucio Bertario, Fernando Ravagnani, Tommaso A Dragani

Oncology reports 14 ( 2 ) 415 - 9 2005.8

Language：English Publishing type：Research paper (scientific journal)

A functional Gly388Arg variation in the FGFR4 gene has been reported to be associated with breast and colorectal cancer prognostic parameters. To further examine the functional role of this genetic polymorphism at the population level, we assessed the presence of the Arg388 allele in 142 breast carcinoma patients, 179 colorectal carcinoma patients and 220 general population controls with respect to an association with cancer prognosis and/or risk. No significant association with cancer risk, survival or any other prognostic parameters was observed in either breast or colorectal cancer. A pooled analysis of the present and published data on nodal status by FGFR4 genotypes revealed no association in either breast cancer [odds ratio (OR), 1.0; 95% confidence interval (CI), 0.7-1.4; 702 subjects] or colorectal cancer (OR, 1.4; 95% CI, 0.6-3.4; 260 cases). Thus, the FGFR4 polymorphism may not be relevant in predicting nodal involvement of breast cancer or colon cancer patients.

　 PREV - NEXT 　

1
2
3
4
5
6