Faculty Profiles - FUJIHARA Kazuya

Papers - FUJIHARA Kazuya

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指先穿刺による血糖およびHbA1c迅速測定をもちいた糖尿病啓発の取り組み(第2報)

山田貴穂, 武田安永, 池田和泉, 竹内瑞希, 國米純也, 中湊大成, 滝澤祥子, 村井幸四郎, 竹内亮, 今西明, 安楽匠, 岸裕太郎, 小松健, 佐藤隆明, 矢口雄大, 山田万祐子, 川田亮, 金子正儀, 鈴木浩史, 松林泰弘, 藤原和哉, 岩永みどり, 鈴木亜希子, 羽入修, 曽根博仁, 新潟県糖尿病協会

糖尿病 63 ( Suppl.1 ) S - 349 2020.8

2型糖尿病患者における野菜と果物の摂取と肥満との関連

竹内瑞希, 藤原和哉, 治田麻理子, 武田安永, 堀川千嘉, 斎藤トシ子, 加藤光敏, 加藤則子, 横山宏樹, 栗原義夫, 岩崎皓一, 宮澤一裕, 山崎勝也, 前川聡, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 243 2020.8

下垂体機能低下症を併発した本態性高Na血症の一例

岸裕太郎, 竹内亮, 山本正彦, 松林泰弘, 山田貴穂, 岩永みどり, 石黒創, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 96 ( 1 ) 256 - 256 2020.8

1型糖尿病に対して膵腎同時移植を施行し透析およびインスリンを離脱した1例

岸裕太郎, 竹内亮, 山本正彦, 松林泰弘, 藤原和哉, 岩永みどり, 山田高穂, 曽根博仁, 三浦宏平, 小林隆, 若井俊文

糖尿病 63 ( 8 ) 558 - 558 2020.8

SGLT2阻害薬投与による肝インスリンクリアランス増加と血中トリグリセリド・βヒドロキシ酪酸レベルの変化との関連について

松林泰弘, 吉田明弘, 菅波秀規, 藤原和哉, 加来浩平, 曽根博仁

日本内分泌学会雑誌 96 ( 1 ) 263 - 263 2020.8

高齢になり副腎皮質機能低下症、甲状腺機能低下症が顕在化した下垂体茎離断症候群に甲状腺乳頭癌を合併した1例

浅島雄弥, 佐藤隆明, 竹内亮, 小松健, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 96 ( 1 ) 309 - 309 2020.8

1型糖尿病に対して膵腎同時移植を施行し透析およびインスリンを離脱した1例

岸裕太郎, 竹内亮, 山本正彦, 松林泰弘, 藤原和哉, 岩永みどり, 山田高穂, 曽根博仁, 三浦宏平, 小林隆, 若井俊文

糖尿病 63 ( 8 ) 558 - 558 2020.8

著明な嚥下障害を呈したKearns-Sayre症候群に合併した糖尿病の1例

種村聡, 山本正彦, 石黒創, 岩永みどり, 松林泰弘, 山田貴穂, 藤原和哉, 渡邊賢一, 曽根博仁

糖尿病 63 ( 8 ) 568 - 568 2020.8

Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice. International journal

Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vengadeshprabhu Karuppagounder, Mst Rejina Afrin, Remya Sreedhar, Meilei Harima, Masahiko Nakamura, Kenichi Watanabe, Satoru Kodama, Kazuya Fujihara, Hirohito Sone

Neurochemistry international 137 104745 - 104745 2020.7

Language：English Publishing type：Research paper (scientific journal)

AIM AND OBJECTIVE: Insulin-induced moderate or severe hypoglycemia (MH or SH) impairs cognition and SH causes neuronal death. On the contrary, alternate day fasting (ADF) protects the brain during excitotoxic stress and improves cognitive function. Unlike the scenario in the periphery, insulin and its relationship towards brain glucose uptake and metabolism are considered to be less significant. Yet, the hypoglycemia associated brain metabolism is not clearly understood. The authors broadly investigated the brain metabolism in various hypoglycemic models such as insulin-induced MH, SH, SH with glucose reperfusion, 24 h fasting and ADF in the cortex or hippocampus of C57BL6/J mice. The authors analyzed the protein expression of insulin signaling kinases (plays a key role in neuronal survival and memory), Bcl-2 associated death promoter (p-BADser155) (dephosphorylation inhibits glucokinase activity and reduces glucose or increases ketone body metabolism in the brain), neuronal-specific glucose transporter 3 (GLUT 3) and nitrotyrosine (marker of nitric oxide which is involved in neuronal glucose uptake via GLUT 3) using western blotting analysis. RESULTS: Insulin-induced MH or SH differentially regulated the brain insulin signaling kinases. The expression of p-BADser155 decreased in all hypoglycemic models except the insulin-induced MH in hippocampus. The trended higher GLUT 3 and increased nitrotyrosine expression of insulin-induced SH were restored after glucose reperfusion. The trended higher or increased GLUT 3 and nitrotyrosine expression of ADF were positively correlated with serum beta-hydroxybutyrate levels. CONCLUSION: During hypoglycemia, it can be suggested that the brain might decrease glucose metabolism via glycolysis or prefer ketone body metabolism (except the insulin-induced MH in hippocampus) by modifying the p-BADser155 expression. In addition to the ketone body metabolism, the brain might adapt to uptake glucose in insulin-induced SH or ADF by modifying the GLUT 3 or nitrotyrosine expression.

DOI： 10.1016/j.neuint.2020.104745

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心不全患者に対する高尿酸血症治療薬の予後改善効果に関するネットワークメタ分析

児玉暁, 藤原和哉, 渡辺賢一, 加藤公則, 曽根博仁

日本動脈硬化学会総会プログラム・抄録集 52回 234 - 234 2020.7

Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes. Reviewed International journal

Takuya Yamaoka, Atsushi Araki, Yoshiaki Tamura, Shiro Tanaka, Kazuya Fujihara, Chika Horikawa, Rei Aida, Chiemi Kamada, Yukio Yoshimura, Tatsumi Moriya, Yasuo Ohashi, Yasuo Akanuma, Hideki Ito, Hirohito Sone

Nutrients 12 ( 6 ) 2020.6

Language：English Publishing type：Research paper (scientific journal)

The aim of this study was to investigate the association between protein intake and mortality risk in patients with type 2 diabetes. We analyzed a pooled data of 2494 diabetic patients from two prospective longitudinal studies. Nutritional intake was assessed using a Food Frequency Questionnaire at baseline. Protein intake per body weight (kg) per day was categorized into quartile groups. Adjusted hazard ratios (HRs) and 95% confidence interval (CI) were calculated using Cox regression analysis. During the six-year follow-up, there were 152 incidents of all-cause mortality. The HR for mortality in the lowest quartile of protein intake per body weight compared with the highest quartile was 2.26 (95% CI: 1.34-3.82, p = 0.002) after adjustment for covariates. Subgroup analyses revealed significant associations between low protein intake and mortality in patients aged over 75 years or under 65 years. After further adjustment of the total energy intake, a significant association between protein intake and mortality remained in patients aged ≥ 75 years, whereas the association was attenuated in those aged < 65 years. Our results suggest that adequate protein intake is necessary in older diabetic patients over 75 years, whereas with diabetes, whereas whole optimal total energy intake is required in younger patients with type 2 diabetes.

DOI： 10.3390/nu12061629

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Vitamin B6 intake and incidence of diabetic retinopathy in Japanese patients with type 2 diabetes: analysis of data from the Japan Diabetes Complications Study (JDCS). Reviewed International journal

Chika Horikawa, Rei Aida, Chiemi Kamada, Kazuya Fujihara, Shiro Tanaka, Sachiko Tanaka, Atsushi Araki, Yukio Yoshimura, Tatsumi Moriya, Yasuo Akanuma, Hirohito Sone

European journal of nutrition 59 ( 4 ) 1585 - 1594 2020.6

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Although vitamin B6 has been suspected to prevent the progression of diabetic retinopathy, evidence of this in patients with type 2 diabetes based on longitudinal studies is sparse. This study investigated the relationship between vitamin B6 intake and the incidence of diabetic retinopathy in Japanese patients with type 2 diabetes. METHODS: The study was part of an examination of a nationwide cohort of patients with type 2 diabetes aged 40-70 years with HbA1c ≥ 48 mmol/mol. After excluding nonresponders to a dietary survey using the Food Frequency Questionnaire based on food groups, 978 patients were analyzed. Primary outcome was the 8-year risk of a diabetic retinopathy event, and Cox regression analyses estimated hazard ratios (HRs) for retinopathy according to vitamin B6 intake adjusted for age, gender, body mass index, HbA1c, smoking, energy intake, and other confounders. RESULTS: Mean vitamin B6 intake in quartiles ranged from 1.1 to 1.6 mg/day, and half of the participants had vitamin B6 intake below the recommended daily dietary allowance according to dietary reference intakes in Japanese adults (men 1.4 mg/day; women 1.2 mg/day). After adjusting for confounders, HRs for diabetic retinopathy in the 2nd, 3rd, and 4th quartile groups of vitamin B6 intake compared with the 1st quartile group were 1.17 (95% confidence interval 0.81-1.69, p = 0.403), 0.88 (0.58-1.34, p = 0.550), and 0.50 (0.30-0.85, p = 0.010), respectively. CONCLUSIONS: Findings suggested that high vitamin B6 intake was associated with a lower incidence of diabetic retinopathy in Japanese with type 2 diabetes.

DOI： 10.1007/s00394-019-02014-4

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糖尿病、非糖尿患者における血糖、血圧、脂質、喫煙の管理目標の達成状況と冠動脈疾患発症の検討

藤原和哉, 山田万佑子, 曽根博仁

日本内科学会雑誌 109 ( Suppl. ) 240 - 240 2020.2

抗体陰性バセドウ病に合併した類もやもや病の1例

滝澤祥子, 今西明, 安楽匠, 川田亮, 佐藤隆明, 金子正儀, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

新潟医学会雑誌 134 ( 2 ) 75 - 76 2020.2

Association of increased hepatic insulin clearance and change in serum triglycerides or β-hydroxybutyrate concentration via the sodium/glucose-cotransporter 2 inhibitor tofogliflozin. Reviewed International journal

Yasuhiro Matsubayashi, Akihiro Yoshida, Hideki Suganami, Taeko Osawa, Kazuo Furukawa, Hiroshi Suzuki, Kazuya Fujihara, Shiro Tanaka, Kohei Kaku, Hirohito Sone

Diabetes, obesity & metabolism 22 ( 6 ) 947 - 956 2020.1

Language：English Publishing type：Research paper (scientific journal)

AIMS: Obesity and hepatic fat accumulation diminish hepatic insulin clearance, which can cause hyperinsulinaemia. Sodium/glucose-cotransporter 2 inhibitors (SGLTis) improve insulin resistance and hyperinsulinaemia by weight loss via increased urinary glucose excretion in type 2 diabetes. However, there are few reports of the influence of SGLT2is on hepatic insulin clearance. We examined the impact of an SGLT2i on hepatic insulin clearance and explored the clinical influence associated with changes in hepatic insulin clearance via an SGLT2i and the mechanism of the effects of SGLT2i. MATERIALS AND METHODS: Data were analysed from 419 patients with type 2 diabetes controlled by diet and exercise. Patients received a placebo or the SGLT2i tofogliflozin (TOFO) (placebo: n = 56; TOFO: n = 363) orally once daily for ≥24 weeks. Hepatic insulin clearance was calculated from the ratio of areas under the curve (AUC) of C-peptide and insulin levels derived from oral meal tolerance test data (C-peptide AUC0-120 min /insulin AUC0-120 min : HICCIR ). The correlation of HICCIR via the SGLT2i with other clinical variables was analysed using multivariate analysis. RESULTS: HICCIR was significantly increased via TOFO at week 24. Furthermore, with TOFO insulin and triglyceride (TG) levels were significantly reduced (P <0.001) and β-hydroxybutyrate (BHB) was significantly elevated (P <0.001). Changes in HICCIR were significantly correlated with changes in TG and BHB via TOFO. CONCLUSIONS: Increased HICCIR was significantly associated with reduced TG via TOFO and contributed to the greater increase in BHB compared with placebo in addition to the correction of hyperinsulinaemia.

DOI： 10.1111/dom.13980

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Combination of diabetes mellitus and lack of habitual physical activity is a risk factor for functional disability in Japanese. Reviewed International journal

Kazuya Fujihara, Yasuhiro Matsubayashi, Mayuko Harada Yamada, Masaru Kitazawa, Masahiko Yamamoto, Masanori Kaneko, Satoru Kodama, Takuya Yahiro, Ayumu Tsutsui, Kiminori Kato, Hirohito Sone

BMJ open diabetes research & care 8 ( 1 ) 2020.1

Language：English

OBJECTIVE: Declining healthy life expectancy due to functional disability is relevant and urgent because of its association with decreased quality of life and also for its enormous socioeconomic impact. The aim of this study is to examine the impact of diabetes, hypertension, dyslipidemia and physical activity habits on functional disability among community-dwelling Japanese adults. RESEARCH DESIGN AND METHODS: This is a population-based retrospective cohort study including 9673 people aged 39-98 years in Japan (4420, men). Functional disability was defined as a condition meeting Japan's new long-term care insurance certification requirements for the need of assistance in the activities of daily living whether by caregivers or assistive devices. Cox proportional-hazards regression model identified variables related to functional disability. RESULTS: Median follow-up was 3.7 years. During the study period, 165 disabilities occurred in the overall study population. Multivariate analysis showed that diabetes (HR 1.74 (95% CI 1.12 to 2.68)) and no physical activity habit (HR 1.83 (1.27 to 2.65)) presented increased risks for disability. HR for disability increased with the number of risk factors (HR of individuals with four conditions, 3.96 (1.59 to 9.99) vs individuals with none of those conditions as a reference). HR for disability among patients with diabetes with and without a physical activity habit was 1.68 (0.70 to 4.04) and 3.19 (1.79 to 5.70), respectively, compared with individuals without diabetes with a physical activity habit. CONCLUSIONS: The combination of diabetes and lack of habitual physical activity is predictive of functional disability in Japanese. Habitual physical activity attenuates the risk of functional disability in patients with diabetes.

DOI： 10.1136/bmjdrc-2019-000901

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副甲状腺癌の全身骨転移と鑑別が困難でありBrown腫瘍が疑われた一例 Reviewed

山本正彦, 種村聡, 石黒創, 松林泰弘, 藤原和哉, 岩永みどり, 山田貴穂, 曽根博仁

日本内分泌学会雑誌 95 ( 3 ) 998 - 998 2020.1

Weight and cardiometabolic risk among adolescents in Agano city, Japan: NICE EVIDENCE Study-Agano 1. International journal

Sakiko Yoshizawa Morikawa, Kazuya Fujihara, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Masahiro Ishizawa, Masahiko Yamamoto, Tomonobu Shiraishi, Hajime Ishiguro, Takaho Yamada, Yohei Ogawa, Hirohito Sone

Asia Pacific journal of clinical nutrition 29 ( 4 ) 856 - 866 2020

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND OBJECTIVES: Pediatric obesity is associated with clustered cardiometabolic risk and the future incidence of cardiovascular disease. However, few studies have determined the effect of pediatric obesity in Asia, where obesity is less common than in Western countries. We aimed to clarify whether weight status including underweight and slightly overweight is associated with metabolic risk factors in Japanese adolescents. METHODS AND STUDY DESIGN: We performed a cross-sectional analysis of 2241 adolescents aged 13-14 years. Participants were classified as underweight, normal weight, slightly overweight, overweight, or obese according to the International Obesity Task Force. The clustered cardiometabolic risk (Z-CMR) was estimated by summing standardized sex-specific Z scores of mean arterial pressure (MAP), non-high-density lipoprotein cholesterol (non-HDLC), and HbA1c. RESULTS: Linear regression analysis showed that MAP, non-HDL-C, and Z-CMR were higher in the slightly overweight, overweight, and obese groups than in the normal weight group after adjusting for confounders. Compared with the normal weight group, the slightly overweight, overweight, and obese groups had higher prevalence of high BP [odds ratios (ORs): 1.38 (95% CI, 1.03, 1.85); 2.63 (1.77, 3.91); and 2.39 (1.57, 3.64), respectively]. Compared with the normal weight group, underweight boys, but not girls, had a lower prevalence of high Z-CMR [OR=0.20 (0.05, 0.84)]. CONCLUSIONS: Adolescents classified as slightly overweight had higher levels of BP, serum lipids, and clustered cardiometabolic risk than those classified as normal weight. This observation showed significant associations between weight status and cardiometabolic risk factors during adolescence even in East Asians.

DOI： 10.6133/apjcn.202012_29(4).0022

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Physical Fitness and Dyslipidemia Among Japanese: A Cohort Study From the Niigata Wellness Study

Haruki Momma, Kiminori Kato, Susumu S. Sawada, Yuko Gando, Ryoko Kawakami, Motohiko Miyachi, Ryoichi Nagatomi, Minoru Tashiro, Yasuhiro Matsubayashi, Satoru Kodama, Midori Iwanaga, Kazuya Fujihara, Hirohito Sone

Journal of Epidemiology 2020

Association between Screen Time Including Smartphone Use and Obesity and Its Associated Lifestyles in School Children in Japan

Ikeda, Izumi, Fujihara, Kazuya, Nedachi, Rina, Morikawa, Sakiko Y., Ishiguro, Hajime, Yamada, Mayuko H., Matsubayashi, Yasuhiro, Yamada, Takaho, Sone, Hirohito

Diabetes 2020

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Papers - FUJIHARA Kazuya