Faculty Profiles - FUJIHARA Kazuya

Papers - FUJIHARA Kazuya

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Impact of Body Mass Index (BMI) and Waist Circumference (WC) on Coronary Artery Disease (CAD) in Japanese with and without Diabetes Mellitus (DM)

Komatsu, Takeshi, Fujihara, Kazuya, Yamada, Mayuko H., Sato, Takaaki, Kitazawa, Masaru, Yamamoto, Masahiko, Seida, Hiroyasu, Yamanaka, Nauta, Matsubayashi, Yasuhiro, Yamada, Takaho, Sone, Hirohito

Diabetes 2020

Medication Adherence (MA) Is an Independent Predictor for Glycemic Control Even after Adjustment for Lifestyle Confounders in Japanese Patients with Type 2 Diabetes

Yaguchi, Yuta, Fujihara, Kazuya, Yamada, Mayuko H., Sato, Takaaki, Kitazawa, Masaru, Yamamoto, Masahiko, Seida, Hiroyasu, Yamanaka, Nauta, Matsubayashi, Yasuhiro, Sone, Hirohito

Diabetes 2020

Predictive Ability of Incident Type 2 Diabetes Mellitus (T2DM) Using Machine Learning Algorithms: A Meta-analysis

Kodama, Satoru, Sato, Takaaki, Yamamoto, Masahiko, Ishiguro, Hajime, Iwanaga, Midori, Fujihara, Kazuya, Yamada, Takaho, Kato, Kiminori, Sone, Hirohito

Diabetes 2020

Randomized Controlled Trial of Ipragliflozin or Sitagliptin Combined with Metformin in Type 2 Diabetes: NISM Study

Kitazawa, Masaru, Katagiri, Takashi, Suzuki, Hiromi, Matsunaga, Satoshi, Yamada, Mayuko H., Ikarashi, Tomoo, Yamamoto, Masahiko, Furukawa, Kazuo, Iwanaga, Midori, Hatta, Mariko, Fujihara, Kazuya, Yamada, Takaho, Tanaka, Shiro, Sone, Hirohito

Diabetes 2020

Physical Fitness (PF), Weight Status, and Metabolic Risk in Japanese Adolescents

Morikawa, Sakiko Y., Fujihara, Kazuya, Nedachi, Rina, Ikeda, Izumi, Takeda, Yasunaga, Takeuchi, Mizuki, Hatta, Mariko, Ishiguro, Hajime, Yamada, Takaho, Sone, Hirohito

Diabetes 2020

Low Level of and Decrease in Serum Amylase (AMY) Increases the Risk of Type 2 Diabetes Mellitus (T2DM)

Ikeda, Izumi, Fujihara, Kazuya, Risa, Igarashi, Yamada, Mayuko H., Nedachi, Rina, Hatta, Mariko, Kodama, Satoru, Mori, Yasumichi, Matsubayashi, Yasuhiro, Arase, Yasuji, Sone, Hirohito, Yamamoto-Honda, Ritsuko

Diabetes 2020

Difference between Comprehensive Physical Fitness Age and Calendar Age Is a Potent Predictor of Incident Metabolic Syndrome (MetS)

Sato, Takaaki, Fujihara, Kazuya, Yamada, Mayuko H., Yaguchi, Yuta, Kitazawa, Masaru, Matsubayashi, Yasuhiro, Iwanaga, Midori, Yamada, Takaho, Kato, Kiminori, Sone, Hirohito

Diabetes 2020

Blood Pressure as Predictor of Coronary Artery Disease (CAD)/Cerebrovascular Disease (CVD) According to Glucose Tolerance Status (GTS): Implications for Updated Guidelines

Yamada, Mayuko H., Fujihara, Kazuya, Yaguchi, Yuta, Osawa, Taeko, Kitazawa, Masaru, Matsubayashi, Yasuhiro, Iwanaga, Midori, Yamada, Takaho, Yamanaka, Nauta, Seida, Hiroyasu, Ogawa, Wataru, Sone, Hirohito

Diabetes 2020

Ability for Detecting or Predicting Hypoglycemia with the Aid of Machine Learning Techniques: A Meta-analysis

Kodama, Satoru, Yamada, Mayuko H., Yaguchi, Yuta, Kitazawa, Masaru, Kaneko, Masanori, Matsubayashi, Yasuhiro, Fujihara, Kazuya, Iwanaga, Midori, Kato, Kiminori, Sone, Hirohito

Diabetes 2020

Association between Plasma Metabolites in the Urea Cycle and Diabetic Kidney Disease (DKD) in a Japanese Population

Yamamoto, Masahiko, Harada, Sei, Okamura, Tomonori, Fujihara, Kazuya, Yaguchi, Yuta, Komatsu, Takeshi, Sato, Takaaki, Kitazawa, Masaru, Yamada, Mayuko H., Kaneko, Masanori, Osawa, Taeko, Matsubayashi, Yasuhiro, Yamada, Takaho, Kodama, Satoru, Sone, Hirohito, Takebayashi, Toru

Diabetes 2020

Association of Plasma Volume with Body Weight and BNP after Long-Term Administration and Subsequent Withdrawal of the SGLT2 Inhibitor Tofogliflozin

Matsubayashi, Yasuhiro, Yoshida, Akihiro, Nojima, Toshiaki, Suganami, Hideki, Fujihara, Kazuya, Kaku, Kohei, Sone, Hirohito

Diabetes 2020

Risk of coronary artery disease according to glucose abnormality status and prior coronary artery disease in Japanese men. Reviewed International journal

Masaru Kitazawa, Kazuya Fujihara, Taeko Osawa, Masahiko Yamamoto, Mayuko Harada Yamada, Masanori Kaneko, Yasuhiro Matsubayashi, Takaho Yamada, Nauta Yamanaka, Hiroyasu Seida, Hirohito Sone

Metabolism: clinical and experimental 101 153991 - 153991 2019.12

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Although glucose abnormality status (GAS), prior coronary artery disease (CAD), and other traditional risk factors affect the incidence of subsequent CAD, their impact in the same cohort has been scantly studied. RESEARCH DESIGN AND METHODS: We analyzed data from a nationwide claims database in Japan that was accumulated during 2008-2016 involving 138,162 men aged 18-72 years. Participants were classified as having normoglycemia, borderline glycemia, or diabetes mellitus (DM) with prior CAD (CAD+) or without prior CAD (CAD-). Cox regression model identified variables related to the incidence of CAD. RESULTS: Among CAD-, management of traditional risks differed from those with and without subsequent CAD events. On the other hand, such differences were weaker in borderline glycemia and DM CAD+, and the influence of traditional risk factors on subsequent CAD was not observed. Cox regression model showed that borderline glycemia and DM confer approximately 1.2- and 2.8-fold excess risks of CAD, respectively, compared with CAD- with normoglycemia. CAD+ confers approximately a 5- to 8-fold increased risk. The impacts of DM and prior CAD additively reached a hazard ratio (HR) of 15.74 (95% confidence interval [CI]: 11.82-21.00). However, the HR in those with borderline glycemia and CAD+ was 7.20 (95% CI: 5.01-10.34), which was not different from those with normoglycemia and CAD+. CONCLUSION: Control status of traditional risk factors and impact on subsequent CAD differ among categories of glycemic status with and without prior CAD. Individualizing treatment strategies is needed in consideration of risk factors, such as GAS and CAD+.

DOI： 10.1016/j.metabol.2019.153991

PubMed

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Relationship Between Number of Multiple Risk Factors and Coronary Artery Disease Risk With and Without Diabetes Mellitus. Reviewed International journal

Mayuko Yamada-Harada, Kazuya Fujihara, Taeko Osawa, Masahiko Yamamoto, Masanori Kaneko, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Nauta Yamanaka, Hiroyasu Seida, Wataru Ogawa, Hirohito Sone

The Journal of clinical endocrinology and metabolism 104 ( 11 ) 5084 - 5090 2019.11

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To determine the degree of control of multiple risk factors under real-world conditions for coronary artery disease (CAD) according to the presence or absence of diabetes mellitus (DM) and to determine whether reaching multifactorial targets for blood pressure (BP), low-density lipoprotein-cholesterol (LDL-C), HbA1c, and current smoking is associated with lower risks for CAD. METHODS: We investigated the effects on subsequent CAD of the number of controlled risk factors among BP, LDL-C, HbA1c, and current smoking in a prospective cohort study using a nationwide claims database of 220,894 individuals in Japan. Cox regression examined risks over a 4.8-year follow-up. RESULTS: The largest percentage of participants had two risk factors at target in patients with DM (39.6%) and subjects without DM (36.4%). Compared with those who had two targets achieved, the risks of CAD among those who had any one and no target achieved were two and four times greater, respectively, regardless of the presence of DM. The effect of composite control was sufficient to bring CAD risk in patients with DM below that for subjects without DM with any two targets achieved, whereas the risk of CAD in the DM group with all four risk factors uncontrolled was 9.4 times more than in the non-DM group who had achieved two targets. CONCLUSIONS: These findings show that composite control of modifiable risk factors has a large effect in patients with and without DM. The effect was sufficient to bring CAD risk in patients with DM below that in the non-DM group who had two targets achieved.

DOI： 10.1210/jc.2019-00168

PubMed

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局在診断に苦慮している周期性ACTH依存性クッシング症候群の1例

金子正儀, 佐藤隆明, 福武嶺一, 滝澤祥子, 今西明, 安楽匠, 小松健, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁, 岡田正康, 小原伸雅, 米岡有一郎

日本内分泌学会雑誌 95 ( 2 ) 765 - 765 2019.10

下垂体性と異所性の鑑別に苦慮したACTH依存性クッシング症候群の1例

佐藤隆明, 金子正儀, 福武嶺一, 小松健, 今西明, 安楽匠, 竹内真理, 竹内亮, 岸裕太郎, 矢口雄大, 山本正彦, 川田亮, 石黒創, 松林康弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

新潟医学会雑誌 133 ( 9-10 ) 352 - 352 2019.10

Attenuation of Weight Loss Through Improved Antilipolytic Effect in Adipose Tissue Via the SGLT2 Inhibitor Tofogliflozin. Reviewed International journal

Akihiro Yoshida, Yasuhiro Matsubayashi, Toshiaki Nojima, Hideki Suganami, Takahiro Abe, Masahiro Ishizawa, Kazuya Fujihara, Shiro Tanaka, Kohei Kaku, Hirohito Sone

The Journal of clinical endocrinology and metabolism 104 ( 9 ) 3647 - 3660 2019.9

Language：English Publishing type：Research paper (scientific journal)

CONTEXT: Although calorie loss from increased urinary glucose excretion continues after long-term treatment with sodium-glucose cotransporter 2 inhibitors (SGLT2is), the mechanisms of the attenuated weight loss due to SGLT2is are not well known. OBJECTIVE: To examine the mechanism of the attenuated weight loss during long-term treatment with an SGLT2i, tofogliflozin, focusing on the antilipolytic effect of insulin on adipose tissue. DESIGN AND PARTICIPANTS: An integrated analysis was performed using data from two phase 3 studies of 52 weeks of tofogliflozin administration. The antilipolytic effect was evaluated using adipose tissue insulin resistance (Adipo-IR) calculated from the product of the levels of fasting insulin (f-IRI) and fasting free fatty acids (f-FFAs). RESULTS: Data from 774 patients with type 2 diabetes (mean age, 58.5 years; glycosylated hemoglobin, 8.1%; body mass index, 25.6 kg/m2; estimated glomerular filtration rate, 83.9 mL/min/1.73m2; 66% men) were analyzed. Weight loss plateaued between weeks 24 and 52 after decreasing significantly. f-IRI levels decreased significantly from baseline to week 24, and the decrease was maintained until Week 52. f-FFA levels significantly increased, peaked at week 24, then declined from weeks 24 to 52. Adipo-IR levels declined progressively throughout the 52 weeks (-3.6 mmol/L·pmol/L and -6.2 mmol/L·pmol/L at weeks 24 and 52, respectively; P < 0.001 baseline vs weeks 24 and 52 and week 24 vs week 52). Higher baseline Adipo-IR levels were independently associated with greater weight loss at week 52. CONCLUSION: The improved antilipolytic effect in adipose tissue may attenuate progressive lipolysis, leading to attenuating future weight loss induced by an SGLT2i in patients with type 2 diabetes.

DOI： 10.1210/jc.2018-02254

PubMed

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大血管障害糖尿病、非糖尿患者における血糖・血圧・脂質・喫煙の管理目標の達成状況と冠動脈疾患発症の関連 Reviewed

山田万祐子, 藤原和哉, 大澤妙子, 山本正彦, 石澤正博, 金子正儀, 松林泰弘, 清田浩康, 山田貴穂, 曽根博仁

糖尿病合併症 33 ( Suppl.1 ) 241 - 241 2019.9

大血管障害耐糖能状態及び心血管疾患既往の有無で層別化した、心血管疾患発症リスクの検討 Reviewed

北澤勝, 藤原和哉, 山田万祐子, 大澤妙子, 山本正彦, 矢口雄大, 金子正儀, 松林泰弘, 山田貴穂, 清田浩康, 曽根博仁

糖尿病合併症 33 ( Suppl.1 ) 242 - 242 2019.9

眼科処置を要する重症糖尿病性眼疾患発生リスクと血液学的因子の関係についての検討 Reviewed

山本正彦, 藤原和哉, 大澤妙子, 山田万祐子, 石澤正博, 石黒創, 鈴木浩史, 松林泰弘, 児玉暁, 長谷部日, 曽根博仁

糖尿病合併症 33 ( Suppl.1 ) 263 - 263 2019.9

運動の疫学を再考する小児生活習慣病対策における体力の意義新潟小児生活習慣病研究から得られた知見を中心として

森川咲子, 藤原和哉, 曽根博仁

日本臨床運動療法学会学術集会プログラム・抄録集 38回 27 - 27 2019.8

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Papers - FUJIHARA Kazuya