Faculty Profiles - FUJIHARA Kazuya

Papers - FUJIHARA Kazuya

Division display 121 - 140 of about 320 ／ All the affair displays >>

Comparing Associations of Dietary Energy Density and Energy Intake, Macronutrients with Obesity in Patients with Type 2 Diabetes (JDDM 63). International journal

Yasunaga Takeda, Kazuya Fujihara, Rina Nedachi, Izumi Ikeda, Sakiko Yoshizawa Morikawa, Mariko Hatta, Chika Horikawa, Mitsutoshi Kato, Noriko Kato, Hiroki Yokoyama, Yoshio Kurihara, Kazuhiro Miyazawa, Hiroshi Maegawa, Hirohito Sone

Nutrients 13 ( 9 ) 2021.9

Language：English Publishing type：Research paper (scientific journal)

To investigate the association between dietary energy density (DED) and obesity in people with type 2 diabetes mellitus. Moreover, we compared the strength of the associations of DED with intake of energy and macronutrients in terms of obesity as well as nutritional factors that have long been used for medical nutritional therapy. Cross-sectionally investigated were 1615 outpatients with type 2 diabetes who attended 26 clinics nationwide with diabetes specialists. Odds ratios (ORs) were calculated for the association between obesity and DED, energy, and macronutrients by quintile categories and a 1 SD increment with adjustment for potential confounders. β coefficients were calculated for the association between body mass index (BMI) and each nutritional factor by 1 SD increments in nutritional values. Multi-adjusted OR for obesity between extreme quintiles of DED was 2.99 (95% confidence interval (95% CI): 2.01-3.12). Conversely, the ORs did not differ significantly according to the quintiles of other nutrient factors. Multi-adjusted β coefficient of BMI per 1 SD according to DED was far higher than those of other nutrient factors (β coefficient 0.65, 95% CI: 0.41-0.88). These findings indicated that DED in persons with type 2 diabetes was positively associated with BMI and the prevalence of obesity. DED was also much more potently associated with obesity and BMI than nutritional indicators such as intake of energy or macronutrients.

DOI： 10.3390/nu13093167

PubMed

researchmap

血清尿酸値と重症糖尿病網膜症との関係

山本正彦, 藤原和哉, 矢口雄大, 大澤妙子, 山田万祐子, 松林泰弘, 長谷部日, 山田貴穂, 児玉暁, 曽根博仁

糖尿病合併症 35 ( Suppl. ) 268 - 268 2021.9

日本人男性における耐糖能別にみた脳卒中既往がその後の脳卒中発症に与える影響

山田万祐子, 藤原和哉, 大江桃子, 大澤妙子, 北澤勝, 松林泰弘, 佐藤隆明, 矢口雄大, 岩永みどり, 山田貴穂, 曽根博仁

糖尿病合併症 35 ( Suppl. ) 174 - 174 2021.9

経口血糖降下薬(OHA)の服薬アドヒアランスおよび血糖コントロールと細小/大血管合併症発症の関連の検討

矢口雄大, 藤原和哉, 山田万祐子, 北澤勝, 山本正彦, 岩永みどり, 山田貴穂, 清田浩康, 松林泰弘, 児玉暁, 曽根博仁

糖尿病合併症 35 ( Suppl. ) 173 - 173 2021.9

Developing a health economic model for Asians with type 2 diabetes based on the Japan Diabetes Complications Study and the Japanese Elderly Diabetes Intervention Trial. International journal

Shiro Tanaka, Jakob Langer, Tim Morton, Nicki Hoskins, Lars Wilkinson, Sachiko Tanaka-Mizuno, Ryo Kawasaki, Tatsumi Moriya, Chika Horikawa, Rei Aida, Atsushi Araki, Kazuya Fujihara, Hirohito Sone

BMJ open diabetes research & care 9 ( 1 ) 2021.8

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Cost-effectiveness analyses are becoming increasingly important in Japan following the introduction of a health technology assessment scheme. The study objective was to develop an economic model to evaluate the cost-effectiveness of two interventions for type 2 diabetes in a Japanese population. RESEARCH DESIGN AND METHODS: The Japan Diabetes Complications Study/Japanese Elderly Diabetes Intervention Trial risk engine (JJRE) Cost-Effectiveness Model (JJCEM) was developed, incorporating validated risk equations in Japanese patients with type 2 diabetes from the JJRE. Weibull regression models were developed for progression of the model outcomes, and a targeted literature review was performed to inform default values for utilities and costs. To illustrate outcomes, two simulated analyses were performed in younger (aged 40 years) and older (aged 80 years) Japanese populations, comparing a hypothetical treatment with placebo. RESULTS: The model considers a population based on user-defined values for 11 baseline characteristic parameters and simulates rates of diabetic complications over a defined time horizon. Costs, quality-adjusted life years, and an incremental cost-effectiveness ratio are estimated. The model provides disaggregated results for two competing interventions, allowing visualization of the key drivers of cost and utility. A scatterplot of simulations and cost-effectiveness acceptability curve are generated for each analysis. CONCLUSIONS: This is the first cost-effectiveness model for East Asian patients with type 2 diabetes, developed using Japan-specific risk equations. This population constitutes the largest share of the global population with diabetes, making this model highly relevant. The model can be used to evaluate the cost-effectiveness of anti-diabetic interventions in patients with type 2 diabetes in Japan and other East Asian populations.

DOI： 10.1136/bmjdrc-2021-002177

PubMed

researchmap

認知機能低下/治療中断による2型糖尿病の血糖増悪が急性発症1型糖尿病であった1例

村井幸四郎, 金子正儀, 岸裕太郎, 今西明, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

糖尿病 64 ( 7 ) 425 - 425 2021.7

日本人2型糖尿病患者における野菜・果物摂取量の組合せと肥満リスク

竹内瑞希, 堀川千嘉, 治田麻理子, 武田安永, 加藤則子, 前川聡, 斎藤トシ子, 藤原和哉, 曽根博仁

日本栄養・食糧学会大会講演要旨集 75回 145 - 145 2021.7

Associations of Systolic Blood Pressure and Diastolic Blood Pressure With the Incidence of Coronary Artery Disease or Cerebrovascular Disease According to Glucose Status

Mayuko Harada Yamada, Kazuya Fujihara, Satoru Kodama, Takaaki Sato, Taeko Osawa, Yuta Yaguchi, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hiroyasu Seida, Wataru Ogawa, Hirohito Sone

Diabetes Care dc202252 - dc202252 2021.5

Accuracy of Japanese claims data in identifying diabetes-related complications. International journal

Kazuya Fujihara, Mayuko Yamada-Harada, Yasuhiro Matsubayashi, Masaru Kitazawa, Masahiko Yamamoto, Yuta Yaguchi, Hiroyasu Seida, Satoru Kodama, Kohei Akazawa, Hirohito Sone

Pharmacoepidemiology and drug safety 30 ( 5 ) 594 - 601 2021.5

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To evaluate the accuracy of various claims-based definitions of diabetes-related complications (coronary artery disease [CAD], heart failure, cerebrovascular disease and dialysis). METHODS: We evaluated data on 1379 inpatients who received care at the Niigata University Medical & Dental Hospital in September 2018. Manual electronic medical chart reviews were conducted for all patients with regard to diabetes-related complications and were used as the gold standard. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of each claims-based definition associated with diabetes-related complications based on Diagnosis Procedure Combination (DPC), International Classification of Diseases, Tenth Revision (ICD-10) codes, procedure codes and medication codes were calculated. RESULTS: DPC-based definitions had higher sensitivity, specificity, and PPV than ICD-10 code definitions for CAD and cerebrovascular disease, with sensitivity of 0.963-1.000 and 0.905-0.952, specificity of 1.000 and 1.000, and PPV of 1.000 and 1.000, respectively. Sensitivity, specificity, and PPV were high using procedure codes for CAD and dialysis, with sensitivity of 0.963 and 1.000, specificity of 1.000 and 1.000, and PPV of 1.000 and 1.000, respectively. DPC and/or ICD-10 codes + medication were better for heart failure than the ICD-10 code definition, with sensitivity of 0.933, specificity of 1.000, and PPV of 1.000. The PPVs were lower than 60% for all diabetes-related complications using ICD-10 codes only. CONCLUSION: The DPC-based definitions for CAD and cerebrovascular disease, procedure codes for CAD and dialysis, and DPC or ICD-10 codes with medication codes for heart failure could accurately identify these diabetes-related complications from claims databases.

DOI： 10.1002/pds.5213

PubMed

researchmap

糖尿病(DM)の有無別にみたeGFRと尿蛋白が透析開始に及ぼす影響

大澤妙子, 藤原和哉, 山田万祐子, 山本正彦, 矢口雄大, 北澤勝, 松林泰弘, 山田貴穂, 曽根博仁

糖尿病 64 ( Suppl.1 ) I - 8 2021.5

服薬アドヒアランスと下肢切断のリスクに関する縦断的検討(第2報)

金子正儀, 藤原和哉, 山田万祐子, 北澤勝, 矢口雄大, 松林泰弘, 山田貴穂, 清田浩康, 曽根博仁

糖尿病 64 ( Suppl.1 ) P - 4 2021.5

糖尿病の悪化と視野障害により再発が疑われたCushing病

今西明, 北川めぐみ, 渡辺聖央, 小松健, 北澤優, 松林泰弘, 岡田正康, 山田貴穂, 藤原和哉, 曽根博仁

糖尿病 64 ( Suppl.1 ) P - 1 2021.5

健診の体力テスト結果を用いた総合体力指標の算出と生活習慣病との関連の検討

佐藤隆明, 藤原和哉, 矢口雄大, 山田万祐子, 北澤勝, 山本正彦, 松林泰弘, 岩永みどり, 山田貴穂, 加藤公則, 曽根博仁

糖尿病 64 ( Suppl.1 ) III - 1 2021.5

機械学習による糖尿病専門医のインスリン選択の予測能の検討及び一般医との比較検討

藤原和哉, 松林泰弘, 山田万祐子, 山本正彦, 飯塚敏浩, 宮村幸祐, 長谷川好範, 山本寛悟, 前川聡, 山崎達也, 曽根博仁

糖尿病 64 ( Suppl.1 ) III - 3 2021.5

SGLT2阻害薬投与早期及び慢性期のヘモグロビン変化予測因子の検討貧血・多血例における評価

松林泰弘, 吉田明弘, 菅波秀規, 矢口雄大, 山本正彦, 石黒創, 北澤勝, 岩永みどり, 山田貴穂, 藤原和哉, 加来浩平, 曽根博仁

糖尿病 64 ( Suppl.1 ) II - 1 2021.5

経口血糖降下薬(OHA)の服薬アドヒアランス(Ad)と生活習慣因子の関連

矢口雄大, 藤原和哉, 山田万祐子, 北澤勝, 金子正儀, 清田浩康, 松林泰弘, 曽根博仁

糖尿病 64 ( Suppl.1 ) III - 1 2021.5

日本人男性における耐糖能と脳卒中既往がその後の脳卒中発症に与える影響リアルワールドデータによる検討

山田万祐子, 藤原和哉, 大江桃子, 大澤妙子, 北澤勝, 松林泰弘, 佐藤隆明, 矢口雄大, 岩永みどり, 清田浩康, 山田貴穂, 曽根博仁

糖尿病 64 ( Suppl.1 ) III - 2 2021.5

これからの糖尿病食事療法における課題と展望大規模データサイエンスから見た新食事ガイドラインに残された課題と解決案患者さんと指導現場の疑問に答えるには

曽根博仁, 堀川千嘉, 藤原和哉, 前川聡, 荒木厚, JDCSグループ, J-EDITグループ, JDDMグループ

糖尿病 64 ( Suppl.1 ) S22 - 5 2021.5

メトホルミン内服中の2型糖尿病患者に対するDPP4阻害薬またはSGLT2阻害薬の追加併用効果の多施設共同無作為化比較試験

北澤勝, 片桐尚, 鈴木裕美, 松永佐澄志, 山田万祐子, 五十嵐智雄, 山本正彦, 古川和郎, 岩永みどり, 治田麻理子, 藤原和哉, 山田貴穂, 田中司郎, 曽根博仁, NISM研究グループ

糖尿病 64 ( Suppl.1 ) I - 6 2021.5

Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database. International journal

Masanori Kaneko, Kazuya Fujihara, Mayuko Yamada Harada, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

Journal of foot and ankle research 14 ( 1 ) 29 - 29 2021.4

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The prevalence of diabetes is rising, and diabetes develops at a younger age in East Asia. Although lower limb amputation negatively affects quality of life and increases the risk of cardiovascular events, little is known about the rates and predictors of amputation among persons with diabetes from young adults to those in the "young-old" category (50-72 y). METHODS: We analyzed data from a nationwide claims database in Japan accumulated from 2008 to 2016 involving 17,288 people with diabetes aged 18-72 y (mean age 50.2 y, HbA1c 7.2%). Amputation occurrence was determined according to information from the claims database. Cox regression model identified variables related to lower limb amputation. RESULTS: The mean follow-up time was 5.3 years, during which time 16 amputations occurred (0.17/1000 person-years). Multivariate Cox regression analysis showed that age (hazard ratio [HR] 1.09 [95% confidence intervals] 1.02-1.16, p = 0.01) and HbA1c (HR 1.46 [1.17-1.81], p < 0.01) were independently associated with amputations. Compared with those aged < 60 years with HbA1c < 8.0%, the HR for amputation was 27.81 (6.54-118.23) in those aged ≥60 years and HbA1c ≥8.0%. CONCLUSIONS: Age and HbA1c were associated with amputations among diabetic individuals, and the rates of amputation were significantly greater in those ≥60 years old and with HbA1c ≥8.0%.

DOI： 10.1186/s13047-021-00474-8

PubMed

researchmap

　 PREV - NEXT 　

<FUJIHARA Kazuya>

Papers - FUJIHARA Kazuya